Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R3	83756	broad.mit.edu	37	1	1268372	1268372	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:1268372C>A	uc010nyk.1	+	4	1347	c.1347C>A	c.(1345-1347)AAC>AAA	p.N449K		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	449	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GCAGCGGAAACGTGGACATGG	0.672			NA											55	37					4.96213e-28	6.8588e-28	0.00361	1	0
PRDM16	63976	broad.mit.edu	37	1	3319455	3319455	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:3319455G>T	uc001akf.2	+	6	857	c.777G>T	c.(775-777)GCG>GCT	p.A259A	PRDM16_uc001akc.2_Silent_p.A259A|PRDM16_uc001akd.2_Silent_p.A259A|PRDM16_uc001ake.2_Silent_p.A259A|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	259					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGGGGGCTGCGCTCTACGAGG	0.642			NA	T	EVI1	MDS|AML								85	33					2.33499e-56	3.57545e-56	0.00361	1	0
KLHL21	9903	broad.mit.edu	37	1	6653499	6653499	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:6653499C>G	uc001aoa.2	-	4	1772	c.1720G>C	c.(1720-1722)GAG>CAG	p.E574Q	KLHL21_uc001anz.1_3'UTR|KLHL21_uc009vme.2_Missense_Mutation_p.E207Q	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	574					anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		CTGTCCAACTCGAAGCCACGC	0.687			NA											5	118					0	0	0.000602	0	0
VPS13D	55187	broad.mit.edu	37	1	12567033	12567033	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:12567033C>T	uc001atv.2	+	69	13062	c.12921C>T	c.(12919-12921)CTC>CTT	p.L4307L	VPS13D_uc001atw.2_Silent_p.L4282L|VPS13D_uc001atx.2_Silent_p.L3494L|VPS13D_uc009vnl.2_RNA|VPS13D_uc010obd.1_Silent_p.L305L|SNORA59B_uc001atz.1_5'Flank	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4306					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACGATGACCTCTACCACTGCC	0.527			NA											9	197					0	0	0.004482	0	0
DHRS3	9249	broad.mit.edu	37	1	12638760	12638760	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:12638760C>G	uc001auc.2	-	4	1151	c.684G>C	c.(682-684)CAG>CAC	p.Q228H	DHRS3_uc001aub.2_Missense_Mutation_p.Q143H	NM_004753	NP_004744	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	228					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			skin(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	CTCTCATGCCCTGGAACATCT	0.612			NA											5	69					0	0	0.001168	0	0
CLCNKB	1188	broad.mit.edu	37	1	16375011	16375011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:16375011C>T	uc001axw.3	+	7	669	c.589C>T	c.(589-591)CAA>TAA	p.Q197*	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Nonsense_Mutation_p.Q197*|CLCNKB_uc001axy.3_5'Flank	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	197					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGAGCAAGCAAAACGAAAT	0.642			NA											27	81					0	0	0.003755	0	0
NBPF1	55672	broad.mit.edu	37	1	16907242	16907242	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:16907242G>A	uc009vos.1	-	16	2477	c.1589C>T	c.(1588-1590)CCA>CTA	p.P530L	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.P259L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	530	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GAGGCTACCTGGGAGAATGTT	0.418			NA											13	832					0	0	0.003163	0	0
CROCC	9696	broad.mit.edu	37	1	17295727	17295727	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:17295727G>T	uc001azt.2	+	32	5262	c.5193G>T	c.(5191-5193)CTG>CTT	p.L1731L	CROCC_uc001azu.2_Silent_p.L1034L|CROCC_uc001azv.2_Silent_p.L67L	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1731					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGCGGGGCCTGACAGAGGCCC	0.657			NA											33	11					1.99505e-19	2.52278e-19	0.012213	1	0
PADI2	11240	broad.mit.edu	37	1	17402181	17402181	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:17402181C>T	uc001baf.2	-	12	1530	c.1448G>A	c.(1447-1449)GGC>GAC	p.G483D	PADI2_uc010ocm.1_Missense_Mutation_p.G367D	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	483					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TACCTTTGTGCCGGGGATGGG	0.587			NA									OREG0013145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	199					0	0	0.001984	0	0
UBR4	23352	broad.mit.edu	37	1	19446747	19446747	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:19446747G>A	uc001bbi.2	-	69	10241	c.10237C>T	c.(10237-10239)CGT>TGT	p.R3413C	UBR4_uc001bbj.1_5'Flank	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3413					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGGAAACAACGCAGGAACTGG	0.547			NA											72	119					0	0	0.00361	0	0
KIF17	57576	broad.mit.edu	37	1	21039953	21039953	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:21039953C>T	uc001bdr.3	-	3	592	c.474G>A	c.(472-474)AAG>AAA	p.K158K	KIF17_uc001bds.3_Silent_p.K158K	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	158	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCACCTCCAGCTTCTGCTTGG	0.582			NA											25	14					0	0	0.00632	0	0
CELA3B	23436	broad.mit.edu	37	1	22310769	22310769	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:22310769C>T	uc001bfk.2	+	6	702	c.587C>T	c.(586-588)TCC>TTC	p.S196F	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	196	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TGGTGGGGTTCCTCCGTGAAG	0.612			NA											53	121					0	0	0.00361	0	0
ZNF683	257101	broad.mit.edu	37	1	26688394	26688394	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:26688394C>T	uc001bmg.1	-	7	1441	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	ZNF683_uc001bmh.1_Silent_p.L421L|ZNF683_uc009vsj.1_Silent_p.L421L	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	441	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGTGCAGCTTCAGGTGGATGT	0.677			NA											7	111					0	0	0.00308	0	0
C1orf172	126695	broad.mit.edu	37	1	27278134	27278134	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:27278134C>T	uc001bni.1	-	2	827	c.738G>A	c.(736-738)AAG>AAA	p.K246K		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	246										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCTGTCAGCTTCTTGAAGA	0.522			NA											8	54					0	0	0.00308	0	0
FAM46B	115572	broad.mit.edu	37	1	27332471	27332471	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:27332471C>G	uc010ofj.1	-	2	1414	c.1242G>C	c.(1240-1242)CTG>CTC	p.L414L		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	414										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		AGGCGTGAGCCAGGAGAGGTT	0.662			NA											34	124					0	0	0.00623	0	0
C1orf94	84970	broad.mit.edu	37	1	34667797	34667797	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:34667797G>C	uc001bxs.3	+	4	1212	c.813G>C	c.(811-813)TGG>TGC	p.W271C	C1orf94_uc001bxt.2_Missense_Mutation_p.W461C	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	271							protein binding				0		Myeloproliferative disorder(586;0.0393)				AGCCACTCTGGCTCAACCTGA	0.522			NA											38	87					0	0	0.00361	0	0
GJB5	2709	broad.mit.edu	37	1	35223715	35223715	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:35223715G>C	uc001bxu.2	+	2	884	c.784G>C	c.(784-786)GAC>CAC	p.D262H	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	262	Cytoplasmic (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)				TCTCTTACCAGACCGCCCCCG	0.567			NA											27	49					0	0	0.00632	0	0
YRDC	79693	broad.mit.edu	37	1	38272561	38272561	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:38272561G>A	uc001cca.1	-	3	605	c.592C>T	c.(592-594)CTC>TTC	p.L198F	C1orf122_uc001ccb.1_5'Flank	NM_024640	NP_078916	Q86U90	YRDC_HUMAN	ischemia/reperfusion inducible protein	198	YrdC-like.				negative regulation of transport	membrane|mitochondrion					0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGGGAGCTGAGGTTGGCACTA	0.507			NA											6	126					0	0	0.001984	0	0
CDC20	991	broad.mit.edu	37	1	43825182	43825182	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:43825182A>G	uc001cix.2	+	3	304	c.203A>G	c.(202-204)CAG>CGG	p.Q68R	CDC20_uc001ciy.2_Missense_Mutation_p.Q68R	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	68					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCCAAGGTTCAGACCACTCCT	0.567	Esophageal Squamous(137;1154 1759 10362 10401 46925)		NA											35	76					0	0	0.004289	0	0
KIAA0467	23334	broad.mit.edu	37	1	43914143	43914143	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:43914143C>A	uc001cjk.1	+	54	7722	c.7260C>A	c.(7258-7260)ATC>ATA	p.I2420I	KIAA0467_uc001cjl.1_Silent_p.I408I	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3319						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTGGGGACATCGACCCCCAGC	0.627			NA											10	33					2.17888e-05	2.27887e-05	0.006214	1	0
PTPRF	5792	broad.mit.edu	37	1	44064417	44064417	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:44064417G>T	uc001cjr.2	+	13	2486	c.2146G>T	c.(2146-2148)GAG>TAG	p.E716*	PTPRF_uc001cjs.2_Nonsense_Mutation_p.E716*|PTPRF_uc001cju.2_Nonsense_Mutation_p.E287*|PTPRF_uc009vwt.2_Nonsense_Mutation_p.E287*|PTPRF_uc001cjv.2_Nonsense_Mutation_p.E185*|PTPRF_uc001cjw.2_5'UTR	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	716	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCGGAAGGTGGAGGTGGAGCC	0.612			NA											63	61					3.06529e-49	4.61441e-49	0.00361	1	0
SCP2	6342	broad.mit.edu	37	1	53427299	53427299	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:53427299A>G	uc001cur.1	+	6	642	c.521A>G	c.(520-522)TAT>TGT	p.Y174C	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_Missense_Mutation_p.Y93C|SCP2_uc010onp.1_Missense_Mutation_p.Y150C|SCP2_uc009vzi.1_Missense_Mutation_p.Y130C|SCP2_uc001cuq.1_Missense_Mutation_p.Y130C	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	174					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						ATGGAAAAATATGGTATGTTA	0.373			NA											15	53					0	0	0.00245	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930348	53930348	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:53930348C>A	uc001cvq.1	+	3	844	c.789C>A	c.(787-789)TAC>TAA	p.Y263*		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	263	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CAAGCTACTACCTgccgccgc	0.537			NA											20	60					1.55795e-14	1.8574e-14	0.012319	1	0
C1orf177	163747	broad.mit.edu	37	1	55277833	55277833	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:55277833C>G	uc001cyb.3	+	6	787	c.733C>G	c.(733-735)CCA>GCA	p.P245A	C1orf177_uc001cya.3_Missense_Mutation_p.P245A	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	245											0						TCGGAGCAAGCCACTGCCTTA	0.572			NA											47	67					0	0	0.013114	0	0
C1orf168	199920	broad.mit.edu	37	1	57257879	57257879	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:57257879G>T	uc001cym.3	-	2	1013	c.607C>A	c.(607-609)CCC>ACC	p.P203T	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.P203T	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	203										ovary(3)|skin(2)	5						AATATTTTGGGGGCCACCACG	0.493			NA											79	138					1.09326e-46	1.63822e-46	0.00361	1	0
CACHD1	57685	broad.mit.edu	37	1	65143951	65143951	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:65143951G>T	uc001dbo.1	+	23	3154	c.3049G>T	c.(3049-3051)GTG>TTG	p.V1017L	CACHD1_uc001dbp.1_Missense_Mutation_p.V772L|CACHD1_uc001dbq.1_Missense_Mutation_p.V772L|CACHD1_uc010opa.1_Missense_Mutation_p.V261L	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1068	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						CGGGGGGATTGTGGGAGCCAA	0.473			NA											18	70					4.75885e-15	5.75762e-15	0.00499	1	0
LEPR	3953	broad.mit.edu	37	1	66067536	66067536	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:66067536C>T	uc001dci.2	+	10	1498	c.1296C>T	c.(1294-1296)ATC>ATT	p.I432I	LEPR_uc001dcg.2_Silent_p.I432I|LEPR_uc001dch.2_Silent_p.I432I|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.I432I|LEPR_uc001dck.2_Silent_p.I432I	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	432	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATGTCAATATCAATATCTCAT	0.303			NA											21	46					0	0	0.008871	0	0
SGIP1	84251	broad.mit.edu	37	1	67206405	67206405	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:67206405G>C	uc001dcr.2	+	23	2516	c.2299G>C	c.(2299-2301)GGG>CGG	p.G767R	SGIP1_uc010opd.1_Missense_Mutation_p.G367R|SGIP1_uc001dcs.2_Missense_Mutation_p.G367R|SGIP1_uc001dct.2_Missense_Mutation_p.G369R|SGIP1_uc009wat.2_Missense_Mutation_p.G561R|SGIP1_uc001dcu.2_Missense_Mutation_p.G272R	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	767					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AGAAAATGGAGGTAATGGAAT	0.313			NA											11	20					0	0	0.008291	0	0
LRRC7	57554	broad.mit.edu	37	1	70484492	70484492	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:70484492G>T	uc001dep.2	+	13	1327	c.1297G>T	c.(1297-1299)GGT>TGT	p.G433C	LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	433						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GCAGCCTCGTGGTGATGAAGG	0.388			NA											24	38					1.55469e-16	1.90927e-16	0.00333	1	0
C1orf173	127254	broad.mit.edu	37	1	75037660	75037660	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:75037660G>T	uc001dgg.2	-	14	3953	c.3734C>A	c.(3733-3735)GCC>GAC	p.A1245D		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1245	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGATCTTTGGCTGCTAGCTC	0.617			NA											52	87					4.01344e-20	5.14813e-20	0.00361	1	0
ELTD1	64123	broad.mit.edu	37	1	79358874	79358874	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:79358874C>T	uc001diq.3	-	13	1906	c.1750G>A	c.(1750-1752)GTT>ATT	p.V584I		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	584	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AAGAGATTAACCTGGAAAAAG	0.303			NA											13	23					0	0	0.001368	0	0
GBP5	115362	broad.mit.edu	37	1	89728468	89728468	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:89728468C>A	uc001dnc.2	-	10	1900	c.1363G>T	c.(1363-1365)GCT>TCT	p.A455S	GBP5_uc001dnd.2_Missense_Mutation_p.A455S|GBP5_uc001dne.1_Missense_Mutation_p.A455S	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	455						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		ACTTCTTCAGCCTAGCAACCC	0.408			NA											10	60					0.000673444	0.00069398	0.008291	1	0
BRDT	676	broad.mit.edu	37	1	92430257	92430257	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:92430257C>T	uc001dok.3	+	3	615	c.266C>T	c.(265-267)GCG>GTG	p.A89V	BRDT_uc001dol.3_Missense_Mutation_p.A89V|BRDT_uc010osz.1_Missense_Mutation_p.A89V|BRDT_uc009wdf.2_Missense_Mutation_p.A16V|BRDT_uc010ota.1_Intron|BRDT_uc010otb.1_Intron|BRDT_uc001dom.3_Missense_Mutation_p.A89V	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	89	Bromo 1.		A -> V (in a gastric adenocarcinoma sample; somatic mutation).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity	p.A89V(1)		stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AAATATTATGCGAAGGCTTCA	0.274			NA											24	45					0	0	0.00278	0	0
FNBP1L	54874	broad.mit.edu	37	1	94000394	94000394	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:94000394G>T	uc001dpw.2	+	9	919	c.919G>T	c.(919-921)GGG>TGG	p.G307W	FNBP1L_uc001dpv.2_Missense_Mutation_p.G307W|FNBP1L_uc010otk.1_Missense_Mutation_p.G127W	NM_001024948	NP_001020119	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like isoform 1	307	Induction of membrane tubulation (By similarity).|Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		ACAGGAGAGTGGGAAGATGGA	0.403			NA											3	4					0.004672	0.00477431	0.004672	1	0
ABCA4	24	broad.mit.edu	37	1	94467521	94467521	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:94467521C>A	uc001dqh.2	-	45	6279	c.6175G>T	c.(6175-6177)GGC>TGC	p.G2059C	ABCA4_uc001dqi.1_Missense_Mutation_p.G178C	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2059	ABC transporter 2.|Cytoplasmic.		G -> A.		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ACAGTCAGGCCCAGGCTCTTA	0.552			NA											26	61					1.74197e-06	1.86776e-06	0.00632	1	0
RWDD3	25950	broad.mit.edu	37	1	95710108	95710108	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:95710108C>G	uc009wdu.2	+	2	503	c.427C>G	c.(427-429)CTT>GTT	p.L143V	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Missense_Mutation_p.L128V|RWDD3_uc009wdt.2_Missense_Mutation_p.L143V|RWDD3_uc001drf.3_Missense_Mutation_p.L143V|RWDD3_uc001drh.3_Missense_Mutation_p.L128V|RWDD3_uc009wdv.2_Intron|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Missense_Mutation_p.L143V	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	143						cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		GTGGATAACTCTTTTGCATTT	0.423			NA											9	132					0	0	0.006214	0	0
LPPR4	9890	broad.mit.edu	37	1	99764620	99764620	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:99764620G>A	uc001dse.2	+	4	674	c.568G>A	c.(568-570)GCT>ACT	p.A190T	LPPR4_uc010oue.1_Missense_Mutation_p.A190T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	190	Helical; (Potential).						phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ATGCTCTACAGCTCTCATTAC	0.368			NA											18	62					0	0	0.007413	0	0
DBT	1629	broad.mit.edu	37	1	100672042	100672042	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:100672042C>A	uc001dta.2	-	9	1201	c.1168G>T	c.(1168-1170)GAT>TAT	p.D390Y	DBT_uc010oug.1_Missense_Mutation_p.D209Y	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	390					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		CCTGTAAGATCAGTGGTGCTG	0.393			NA											87	225					1.31969e-37	1.91599e-37	0.00361	1	0
VCAM1	7412	broad.mit.edu	37	1	101200239	101200241	+	Missense_Mutation	TNP	CCA	CCA	AAT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	CCA	CCA	-	-	CCA	CCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:101200239_101200241CCA>AAT	uc001dti.2	+	8	2094_2096	c.1974_1976CCA>AAT	c.(1972-1977)GCCCAG>GCAATG	p.Q659M	VCAM1_uc001dtj.2_Missense_Mutation_p.Q567M|VCAM1_uc010ouj.1_Missense_Mutation_p.Q597M	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	659	Ig-like C2-type 7.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TCCGAAAGGCCCAGTTGAAGGAT	0.394			NA											16	56					0	0	0.004672	0	0
COL11A1	1301	broad.mit.edu	37	1	103355016	103355016	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:103355016C>A	uc001dul.2	-	59	4777	c.4459G>T	c.(4459-4461)GAT>TAT	p.D1487Y	COL11A1_uc001duk.2_Missense_Mutation_p.D683Y|COL11A1_uc001dum.2_Missense_Mutation_p.D1499Y|COL11A1_uc001dun.2_Missense_Mutation_p.D1448Y|COL11A1_uc009weh.2_Missense_Mutation_p.D1371Y	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1487	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTCACCCCATCCCCTTTTGCT	0.368			NA											24	72					1.77063e-15	2.15823e-15	0.005443	1	0
GPR61	83873	broad.mit.edu	37	1	110086457	110086457	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:110086457C>A	uc001dxy.2	+	2	1496	c.813C>A	c.(811-813)GCC>GCA	p.A271A		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	271	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GCTCGGGGGCCCCCCAGACCA	0.657			NA											57	101					2.47907e-22	3.25668e-22	0.00361	1	0
KCNA10	3744	broad.mit.edu	37	1	111061349	111061349	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:111061349C>T	uc001dzt.1	-	1	449	c.61G>A	c.(61-63)GAA>AAA	p.E21K		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	21						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCTTGGATTTCATCTGAATTA	0.522			NA											4	55					0	0	0.009096	0	0
LINGO4	339398	broad.mit.edu	37	1	151774557	151774557	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:151774557G>C	uc001ezf.1	-	2	814	c.624C>G	c.(622-624)GCC>GCG	p.A208A		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	208	Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TAAGCCTTAGGGCCACTAGTG	0.642			NA											6	135					0	0	0.001168	0	0
RPTN	126638	broad.mit.edu	37	1	152129352	152129352	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:152129352G>T	uc001ezs.1	-	3	288	c.223C>A	c.(223-225)CTC>ATC	p.L75I		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	75	S-100-like (By similarity).|EF-hand 2.					proteinaceous extracellular matrix	calcium ion binding				0						ACCAACAAGAGGTACTCATGA	0.458			NA											101	115					1.59803e-59	2.4585e-59	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152278877	152278877	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:152278877G>T	uc001ezu.1	-	3	8521	c.8485C>A	c.(8485-8487)CGT>AGT	p.R2829S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2829	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGCCCACGGGAGGCATCA	0.572			NA							Ichthyosis				142	368					8.87325e-63	1.37592e-62	0.00361	1	0
SPRR2D	6703	broad.mit.edu	37	1	153012673	153012673	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:153012673G>T	uc001fbb.2	-	2	210	c.150C>A	c.(148-150)TGC>TGA	p.C50*	SPRR2D_uc009wnz.2_RNA	NM_006945	NP_008876	P22532	SPR2D_HUMAN	small proline-rich protein 2D	50					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATTTCTGCTGGCACTGCTGAG	0.592			NA											181	277					8.87325e-63	1.37592e-62	0.00361	1	0
ATP8B2	57198	broad.mit.edu	37	1	154309845	154309845	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:154309845A>G	uc001fey.1	+	11	1105	c.916A>G	c.(916-918)ATG>GTG	p.M306V	ATP8B2_uc001few.2_Missense_Mutation_p.M287V|ATP8B2_uc001fex.2_Missense_Mutation_p.M320V	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	306	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCTGGTTTGCATGGGGGTGAT	0.542			NA											92	152					0	0	0.00361	0	0
KCNN3	3782	broad.mit.edu	37	1	154744815	154744815	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:154744815G>A	uc001ffp.2	-	3	1398	c.1084C>T	c.(1084-1086)CGC>TGC	p.R362C	KCNN3_uc001ffo.2_Missense_Mutation_p.R57C|KCNN3_uc009wox.1_Missense_Mutation_p.R362C	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	367						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TACAGGATGCGCTCGTAGGTC	0.587			NA											5	53					0	0	0.000602	0	0
ASH1L	55870	broad.mit.edu	37	1	155451617	155451617	+	Silent	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:155451617T>G	uc009wqq.2	-	3	1524	c.1044A>C	c.(1042-1044)CCA>CCC	p.P348P	ASH1L_uc001fkt.2_Silent_p.P348P|ASH1L_uc009wqr.1_Silent_p.P348P	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	348					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCACTAAACCTGGAACAATAC	0.393			NA											134	184					0	0	0.00361	0	0
FCRL3	115352	broad.mit.edu	37	1	157665859	157665859	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:157665859A>G	uc001frb.2	-	7	1395	c.1103T>C	c.(1102-1104)CTC>CCC	p.L368P	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.L368P|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.L94P|FCRL3_uc001frc.1_Missense_Mutation_p.L368P	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	368	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CCACGTGCTGAGGATGGGGCT	0.532			NA											11	94					0	0	0.001368	0	0
MNDA	4332	broad.mit.edu	37	1	158812024	158812024	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:158812024C>A	uc001fsz.1	+	2	281	c.81C>A	c.(79-81)TCC>TCA	p.S27S		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	27	DAPIN.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					CAATTAAGTCCTTACTGGCCT	0.338			NA											28	47					4.7796e-09	5.29866e-09	0.004656	1	0
ADAMTS4	9507	broad.mit.edu	37	1	161163875	161163875	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:161163875G>T	uc001fyt.3	-	5	1826	c.1398C>A	c.(1396-1398)CCC>CCA	p.P466P		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	466	Disintegrin.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGGCAGCACAGGGCGGCGGCA	0.652			NA											52	95					2.27459e-33	3.24469e-33	0.00361	1	0
NUF2	83540	broad.mit.edu	37	1	163315606	163315606	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:163315606G>C	uc001gcq.1	+	11	1246	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	NUF2_uc001gcp.2_Missense_Mutation_p.E316Q|NUF2_uc001gcr.1_Missense_Mutation_p.E316Q|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	316	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TATCTTAAAGGAGGTTTGTAT	0.318			NA											13	47					0	0	0.001855	0	0
MAEL	84944	broad.mit.edu	37	1	166959053	166959053	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:166959053C>T	uc001gdy.1	+	2	283	c.212C>T	c.(211-213)CCC>CTC	p.P71L	MAEL_uc001gdz.1_Intron|MAEL_uc009wvf.1_5'Flank	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	71	HMG box.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						GACCCTGGGCCCTCAGAGAAG	0.398			NA											37	34					0	0	0.005524	0	0
BAT2L2	23215	broad.mit.edu	37	1	171491391	171491391	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:171491391A>T	uc010pmg.1	+	7	1086	c.820A>T	c.(820-822)ACA>TCA	p.T274S	BAT2L2_uc001ghr.1_Missense_Mutation_p.T276S	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	274							protein C-terminus binding				0						TTTATCTGAAACAAACAAGTA	0.363			NA											7	93					0	0	0.004482	0	0
TNN	63923	broad.mit.edu	37	1	175046886	175046886	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:175046886G>T	uc001gkl.1	+	2	445	c.332G>T	c.(331-333)CGG>CTG	p.R111L	TNN_uc010pmx.1_Missense_Mutation_p.R111L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	111					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTCCTGGCCCGGGTGAAGAAG	0.577			NA											25	55					2.12542e-12	2.47965e-12	0.00632	1	0
TNN	63923	broad.mit.edu	37	1	175086186	175086186	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:175086186C>T	uc001gkl.1	+	10	2344	c.2231C>T	c.(2230-2232)TCT>TTT	p.S744F		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	744	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGCTACACCTCTGCCAAGGAC	0.632			NA											9	196					0	0	0.004482	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526309	176526309	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:176526309G>T	uc001gkz.2	+	2	2015	c.851G>T	c.(850-852)CGG>CTG	p.R284L	PAPPA2_uc001gky.1_Missense_Mutation_p.R284L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	284					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAGATTCCCCGGGAGGCGTTC	0.572			NA											21	24					1.01871e-10	1.16628e-10	0.008871	1	0
RASAL2	9462	broad.mit.edu	37	1	178425883	178425883	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:178425883C>T	uc001glr.2	+	11	1941	c.1816C>T	c.(1816-1818)CCT>TCT	p.P606S	RASAL2_uc001glq.2_Missense_Mutation_p.P747S|RASAL2_uc009wxc.2_Missense_Mutation_p.P120S	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	606					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GGGGCCTCTCCCTCGTGTTCT	0.448			NA											131	325					0	0	0.00361	0	0
MR1	3140	broad.mit.edu	37	1	181018349	181018349	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:181018349G>T	uc001goq.1	+	2	234	c.229G>T	c.(229-231)GCG>TCG	p.A77S	MR1_uc001gop.2_Missense_Mutation_p.A77S|MR1_uc001gor.1_Missense_Mutation_p.A77S|MR1_uc001gos.1_Missense_Mutation_p.A77S|MR1_uc010pns.1_Missense_Mutation_p.A77S	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	77	Extracellular (Potential).|Ligand-binding.|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						AGAGAACCTCGCGCCTGATCA	0.562	Colon(174;1412 1962 45296 46549 47110)		NA											32	44					8.88839e-20	1.12978e-19	0.010818	1	0
RNASEL	6041	broad.mit.edu	37	1	182545507	182545507	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:182545507C>T	uc001gpj.1	-	5	2090	c.1923G>A	c.(1921-1923)ATG>ATA	p.M641I	RNASEL_uc009wxz.1_Missense_Mutation_p.M641I	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	641	KEN.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TCATTTTTTTCATAACACATT	0.299			NA							Hereditary_Prostate_Cancer				11	37					0	0	0.008291	0	0
HMCN1	83872	broad.mit.edu	37	1	186120472	186120472	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:186120472C>T	uc001grq.1	+	94	14978	c.14749C>T	c.(14749-14751)CGT>TGT	p.R4917C	HMCN1_uc001grs.1_Missense_Mutation_p.R486C	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4917	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAATGTACCTCGTAGTCTTGG	0.323			NA											19	61					0	0	0.010504	0	0
CFH	3075	broad.mit.edu	37	1	196648785	196648785	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:196648785G>T	uc001gtj.3	+	6	892	c.652G>T	c.(652-654)GGA>TGA	p.G218*	CFH_uc001gti.3_Nonsense_Mutation_p.G218*|CFH_uc009wyw.2_Nonsense_Mutation_p.G218*|CFH_uc009wyx.2_Nonsense_Mutation_p.G154*	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	218	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGTTATAAATGGATCTCCTAT	0.303			NA											21	54					6.33239e-15	7.59576e-15	0.010504	1	0
CFHR5	81494	broad.mit.edu	37	1	196953168	196953168	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:196953168C>A	uc001gts.3	+	3	459	c.331C>A	c.(331-333)CAA>AAA	p.Q111K		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	111	Sushi 2.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TGATACTGTACAAATTATTTG	0.383			NA											27	45					3.90053e-15	4.73084e-15	0.012213	1	0
CFHR5	81494	broad.mit.edu	37	1	196953194	196953195	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:196953194_196953195CC>AA	uc001gts.3	+	3	485_486	c.357_358CC>AA	c.(355-360)AGCCTT>AGAATT	p.119_120SL>RI		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	119_120	Sushi 2.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						CAGGATACAGCCTTCAAAACAA	0.396			NA											28	39					0	0	0.004672	0	0
KIF21B	23046	broad.mit.edu	37	1	200959710	200959710	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:200959710G>T	uc001gvs.1	-	19	3146	c.2829C>A	c.(2827-2829)CTC>CTA	p.L943L	KIF21B_uc001gvr.1_Silent_p.L943L|KIF21B_uc009wzl.1_Silent_p.L943L|KIF21B_uc010ppn.1_Silent_p.L943L	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	943	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TCACCTTGATGAGCCGCTCCA	0.582			NA											21	60					1.96292e-10	2.23682e-10	0.010504	1	0
NFASC	23114	broad.mit.edu	37	1	204971877	204971877	+	Splice_Site	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:204971877G>T	uc001hbj.2	+	27	3617	c.3289_splice	c.e27+1	p.A1097_splice	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Intron|NFASC_uc010prc.1_Intron|NFASC_uc001hbl.1_Intron|NFASC_uc001hbm.1_Splice_Site_p.A120_splice|NFASC_uc009xbh.1_Intron	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor						axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACCAGTACAGGTGAGAGGGGA	0.552			NA											4	60					0.000602214	0.000621232	0.000602	1	0
IL20	50604	broad.mit.edu	37	1	207039976	207039976	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:207039976C>G	uc001her.2	+	3	417	c.373C>G	c.(373-375)CTC>GTC	p.L125V	IL20_uc010pry.1_Missense_Mutation_p.L196V|IL20_uc009xby.2_Missense_Mutation_p.L125V	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	interleukin 20 precursor	125					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding				0	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		GGACCTCCGGCTCTGTGTGAG	0.483			NA											152	185					0	0	0.00361	0	0
LAMB3	3914	broad.mit.edu	37	1	209797302	209797302	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:209797302C>T	uc001hhg.2	-	14	2410	c.2020G>A	c.(2020-2022)GAG>AAG	p.E674K	LAMB3_uc009xco.2_Missense_Mutation_p.E674K|LAMB3_uc001hhh.2_Missense_Mutation_p.E674K|LAMB3_uc010psl.1_RNA|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	674	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GACAACGTCTCCTCCTCCAGG	0.507			NA											37	93					0	0	0.00623	0	0
USH2A	7399	broad.mit.edu	37	1	215821958	215821958	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:215821958G>C	uc001hku.1	-	66	14881	c.14494C>G	c.(14494-14496)CTG>GTG	p.L4832V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4832	Extracellular (Potential).|Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAGAGGACAGTCCTGAGGGT	0.567			NA								HNSCC(13;0.011)			38	78					0	0	0.004289	0	0
USH2A	7399	broad.mit.edu	37	1	215933050	215933050	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:215933050C>G	uc001hku.1	-	57	11570	c.11183G>C	c.(11182-11184)GGC>GCC	p.G3728A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3728	Fibronectin type-III 22.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCCTCACTGCCACCCAGGAA	0.403			NA								HNSCC(13;0.011)			36	78					0	0	0.004878	0	0
RRP15	51018	broad.mit.edu	37	1	218458660	218458660	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:218458660T>C	uc001hlj.2	+	1	32	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	1						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		CGCAGAAAAATGGCAGCCGCC	0.562			NA											16	52					0	0	0.00278	0	0
ITPKB	3707	broad.mit.edu	37	1	226923860	226923860	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:226923860C>T	uc010pvo.1	-	2	1640	c.1300G>A	c.(1300-1302)GGG>AGG	p.G434R	ITPKB_uc001hqh.2_Missense_Mutation_p.G434R	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	434							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CAACGCCCCCCGCCCACGGGG	0.706	Colon(84;110 1851 5306 33547)		NA											17	40					0	0	0.004007	0	0
NUP133	55746	broad.mit.edu	37	1	229606485	229606485	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:229606485G>C	uc001htn.2	-	15	2010	c.1918C>G	c.(1918-1920)CTC>GTC	p.L640V		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	640					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TGCTCACAGAGCAACAGTCGA	0.483			NA											15	110					0	0	0.004007	0	0
PGBD5	79605	broad.mit.edu	37	1	230492796	230492796	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:230492796G>A	uc010pwb.1	-	2	396	c.396C>T	c.(394-396)CTC>CTT	p.L132L	PGBD5_uc001htv.2_Silent_p.L231L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	132						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GGCTCATGACGAGGGCGAGGC	0.622			NA											16	73					0	0	0.003163	0	0
EGLN1	54583	broad.mit.edu	37	1	231557539	231557539	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:231557539G>A	uc001huv.2	-	1	3252	c.96C>T	c.(94-96)CGC>CGT	p.R32R	EGLN1_uc001huu.3_5'Flank	NM_022051	NP_071334	Q9GZT9	EGLN1_HUMAN	egl nine homolog 1	32	MYND-type.				negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding				0		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	AGCGGCTGCAGCGCAGCAGGT	0.667			NA											5	17					0	0	0.001168	0	0
NID1	4811	broad.mit.edu	37	1	236157056	236157056	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:236157056C>A	uc001hxo.2	-	13	2746	c.2644G>T	c.(2644-2646)GGG>TGG	p.G882W	NID1_uc009xgd.2_Missense_Mutation_p.G749W|NID1_uc009xgc.2_5'UTR	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	882	Thyroglobulin type-1.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCGTAGTGCCCGTGCGCATCG	0.697			NA											20	29					1.10513e-12	1.29086e-12	0.002299	1	0
RYR2	6262	broad.mit.edu	37	1	237777971	237777971	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:237777971C>A	uc001hyl.1	+	37	5663	c.5543C>A	c.(5542-5544)CCC>CAC	p.P1848H		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1848	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGATTGAGCCCAGTGTGTTT	0.493			NA											42	119					1.47197e-15	1.80091e-15	0.007835	1	0
KIF26B	55083	broad.mit.edu	37	1	245848725	245848725	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:245848725G>A	uc001ibf.1	+	12	2880	c.2440G>A	c.(2440-2442)GGC>AGC	p.G814S	KIF26B_uc001ibg.1_Missense_Mutation_p.G432S|KIF26B_uc001ibh.1_Missense_Mutation_p.G56S	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	814					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGCTCGTCCGGCGGGGAGAG	0.642			NA											5	40					0	0	0.001984	0	0
CNST	163882	broad.mit.edu	37	1	246811011	246811011	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:246811011C>G	uc001ibp.2	+	9	1886	c.1508C>G	c.(1507-1509)TCA>TGA	p.S503*	CNST_uc001ibo.3_Nonsense_Mutation_p.S503*	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	503					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						CAGGCTGACTCAGACGGTTCT	0.468			NA											8	128					0	0	0.00308	0	0
ZNF670	93474	broad.mit.edu	37	1	247201040	247201040	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:247201040C>A	uc001icd.1	-	4	1052	c.881G>T	c.(880-882)AGA>ATA	p.R294I	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	294	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TCTGAGGACTCTGGAACATCT	0.403			NA											62	136					2.75338e-15	3.34363e-15	0.00361	1	0
ZNF669	79862	broad.mit.edu	37	1	247264069	247264069	+	Silent	SNP	A	A	G	rs142281141		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:247264069A>G	uc001ice.2	-	4	1175	c.1002T>C	c.(1000-1002)TAT>TAC	p.Y334Y	ZNF669_uc001icf.2_Silent_p.Y248Y	NM_024804	NP_079080	Q96BR6	ZN669_HUMAN	zinc finger protein 669 isoform 1	334	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TGGTACATTTATAGGGTCTTT	0.413			NA											77	93					0	0	0.00361	0	0
OR2T3	343173	broad.mit.edu	37	1	248637229	248637229	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:248637229C>T	uc001iel.1	+	1	578	c.578C>T	c.(577-579)TCC>TTC	p.S193F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGAAGCTCTCCTGCTCTGAC	0.517			NA											131	227					0	0	0.00361	0	0
ZMYND11	10771	broad.mit.edu	37	10	255971	255971	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:255971T>A	uc010pzt.1	+	3	687	c.259T>A	c.(259-261)TTG>ATG	p.L87M	ZMYND11_uc001ifk.2_Missense_Mutation_p.L87M|ZMYND11_uc010pzu.1_Missense_Mutation_p.L87M|ZMYND11_uc010pzv.1_Missense_Mutation_p.L87M|ZMYND11_uc010pzw.1_Missense_Mutation_p.L87M|ZMYND11_uc001ifm.2_Missense_Mutation_p.L87M|ZMYND11_uc010pzx.1_Missense_Mutation_p.L87M|ZMYND11_uc001ifn.2_Missense_Mutation_p.L87M|ZMYND11_uc009xhg.2_Missense_Mutation_p.L70M|ZMYND11_uc009xhh.2_Missense_Mutation_p.L41M|ZMYND11_uc010pzy.1_Missense_Mutation_p.L41M	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	47					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGGATATTGGTTGCCAGGAGA	0.353			NA											31	90					0	0	0.012213	0	0
ANKRD16	54522	broad.mit.edu	37	10	5929981	5929981	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:5929981C>G	uc010qat.1	-	2	907	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	ANKRD16_uc009xie.2_Missense_Mutation_p.E122Q|ANKRD16_uc009xif.2_Missense_Mutation_p.E122Q|ANKRD16_uc001iiq.2_Missense_Mutation_p.E122Q|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	122	ANK 3.										0						TCCACCAGCTCCTGGATCACC	0.537			NA											47	233					0	0	0.00361	0	0
IL2RA	3559	broad.mit.edu	37	10	6063568	6063568	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:6063568G>T	uc001iiz.1	-	4	615	c.456C>A	c.(454-456)TGC>TGA	p.C152*	IL2RA_uc009xih.1_Intron|IL2RA_uc001ija.1_Intron	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	152	Sushi 2.|Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ATCCCTGGACGCACTGATAAT	0.527			NA											60	160					5.73332e-34	8.20241e-34	0.00361	1	0
ITIH2	3698	broad.mit.edu	37	10	7759635	7759635	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:7759635C>A	uc001ijs.2	+	6	676	c.514C>A	c.(514-516)CTC>ATC	p.L172I		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	172	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AGTAAATGTCCTCCCAGGAGC	0.493			NA											72	267					1.79293e-35	2.58774e-35	0.00361	1	0
KIN	22944	broad.mit.edu	37	10	7808025	7808025	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:7808025C>A	uc001ijt.2	-	9	888	c.840G>T	c.(838-840)TGG>TGT	p.W280C	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.W280C|KIN_uc010qba.1_Missense_Mutation_p.W174C	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	280					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CAGGCTGTAGCCAGTAGTCTG	0.318			NA											19	62					1.64113e-05	1.71828e-05	0.010504	1	0
ITGA8	8516	broad.mit.edu	37	10	15617523	15617523	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:15617523C>A	uc001ioc.1	-	24	2443	c.2443G>T	c.(2443-2445)GAG>TAG	p.E815*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.E800*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	815	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CCAACCTCCTCCTCTTTGTGG	0.423			NA											22	115					6.21321e-17	7.70753e-17	0.00278	1	0
STAM	8027	broad.mit.edu	37	10	17726723	17726723	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:17726723C>A	uc001ipj.1	+	3	391	c.175C>A	c.(175-177)CCT>ACT	p.P59T	STAM_uc010qcf.1_Intron	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	59	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						CCACAAAGATCCTCACGTTGC	0.373			NA											10	97					0.000978159	0.00100587	0.010729	1	0
SLC39A12	221074	broad.mit.edu	37	10	18250525	18250525	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:18250525G>T	uc001ipo.2	+	3	550	c.277G>T	c.(277-279)GCA>TCA	p.A93S	SLC39A12_uc001ipn.2_Missense_Mutation_p.A93S|SLC39A12_uc001ipp.2_Missense_Mutation_p.A93S|SLC39A12_uc010qck.1_5'UTR	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	93	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TGAACCAGATGCACTATTACT	0.373			NA											36	60					6.53348e-20	8.34786e-20	0.003755	1	0
PIP4K2A	5305	broad.mit.edu	37	10	22856817	22856817	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:22856817C>T	uc001irl.3	-	6	889	c.641G>A	c.(640-642)GGC>GAC	p.G214D	PIP4K2A_uc010qcu.1_Missense_Mutation_p.G74D	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	214	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						CACTGTAGAGCCCTGAAACAC	0.483			NA											31	179					0	0	0.010818	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762923	24762923	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:24762923C>G	uc001iru.3	+	6	2016	c.1613C>G	c.(1612-1614)CCT>CGT	p.P538R	KIAA1217_uc001irs.2_Missense_Mutation_p.P458R|KIAA1217_uc001irt.3_Missense_Mutation_p.P538R|KIAA1217_uc010qcy.1_Missense_Mutation_p.P538R|KIAA1217_uc010qcz.1_Missense_Mutation_p.P538R|KIAA1217_uc001irv.1_Missense_Mutation_p.P388R|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.P256R|KIAA1217_uc001irz.2_Missense_Mutation_p.P256R|KIAA1217_uc001irx.2_Missense_Mutation_p.P256R|KIAA1217_uc001iry.2_Missense_Mutation_p.P256R	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	538					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GACCTCGGCCCTCCTCTAATG	0.547			NA											54	65					0	0	0.00361	0	0
SVIL	6840	broad.mit.edu	37	10	29779846	29779846	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:29779846G>A	uc001iut.1	-	22	4875	c.4122C>T	c.(4120-4122)CTC>CTT	p.L1374L	SVIL_uc010qdw.1_Silent_p.L288L|SVIL_uc001iuu.1_Silent_p.L948L|SVIL_uc009xlc.2_Silent_p.L166L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1374					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ATTCCTGAAGGAGATCTTCTC	0.527			NA											14	120					0	0	0.004007	0	0
ZEB1	6935	broad.mit.edu	37	10	31810622	31810622	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:31810622G>C	uc001ivs.3	+	7	2422	c.2359G>C	c.(2359-2361)GAA>CAA	p.E787Q	ZEB1_uc001ivr.3_Missense_Mutation_p.E569Q|ZEB1_uc010qee.1_Missense_Mutation_p.E569Q|ZEB1_uc010qef.1_Missense_Mutation_p.E569Q|ZEB1_uc009xlj.1_Missense_Mutation_p.E713Q|ZEB1_uc010qeg.1_Missense_Mutation_p.E646Q|ZEB1_uc009xlk.1_Missense_Mutation_p.E569Q|ZEB1_uc001ivt.3_Missense_Mutation_p.E569Q|ZEB1_uc001ivu.3_Missense_Mutation_p.E788Q|ZEB1_uc001ivv.3_Missense_Mutation_p.E767Q|ZEB1_uc010qeh.1_Missense_Mutation_p.E720Q|ZEB1_uc009xlo.1_Missense_Mutation_p.E770Q|ZEB1_uc009xlp.2_Missense_Mutation_p.E771Q	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	787					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TACAGACTCAGAACCAGTTGT	0.448	Ovarian(40;423 959 14296 36701 49589)		NA											12	86					0	0	0.010729	0	0
RET	5979	broad.mit.edu	37	10	43622127	43622127	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:43622127C>T	uc001jal.2	+	19	3334	c.3144C>T	c.(3142-3144)CTC>CTT	p.L1048L	RET_uc001jak.1_Silent_p.L1048L|RET_uc010qez.1_Silent_p.L794L	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	1048	Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ATGCCCCCCTCCCTCGAGCCC	0.522	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				71	70					0	0	0.00361	0	0
FRMPD2	143162	broad.mit.edu	37	10	49414917	49414917	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:49414917C>T	uc001jgi.2	-	14	1778	c.1671G>A	c.(1669-1671)AGG>AGA	p.R557R	FRMPD2_uc001jgh.2_Silent_p.R525R|FRMPD2_uc001jgj.2_Silent_p.R535R	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	557	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTTCTGGCCTCCTCTTCTCTG	0.488			NA											55	53					0	0	0.00361	0	0
ERCC6	2074	broad.mit.edu	37	10	50691563	50691563	+	Splice_Site	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:50691563C>A	uc001jhs.3	-	9	1976	c.1822_splice	c.e9-1	p.E608_splice	ERCC6_uc010qgr.1_Splice_Site|ERCC6_uc001jhr.3_Splice_Site_p.E8_splice	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent						base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TTAGTTTCTCCTGAGACCACA	0.348			NA						Direct_reversal_of_damage|NER					22	82					1.9806e-07	2.16145e-07	0.002299	1	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:51093329C>T	uc001jif.2	-	8	2011	c.1750G>A	c.(1750-1752)GCA>ACA	p.A584T	PARG_uc001jih.2_Missense_Mutation_p.A584T|PARG_uc001jig.2_Missense_Mutation_p.A170T|PARG_uc010qgv.1_Intron|PARG_uc009xoi.2_Intron|PARG_uc010qgw.1_Missense_Mutation_p.A475T|PARG_uc009xoj.2_Missense_Mutation_p.A135T|PARG_uc010qgx.1_Missense_Mutation_p.A502T	NM_003631	NP_003622	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318			NA											4	100					0	0	0.009096	0	0
PCDH15	65217	broad.mit.edu	37	10	55617011	55617011	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:55617011T>C	uc001jju.1	-	28	4125	c.3730A>G	c.(3730-3732)AAT>GAT	p.N1244D	PCDH15_uc010qhq.1_Missense_Mutation_p.N1249D|PCDH15_uc010qhr.1_Missense_Mutation_p.N1244D|PCDH15_uc010qhs.1_Missense_Mutation_p.N1256D|PCDH15_uc010qht.1_Missense_Mutation_p.N1251D|PCDH15_uc010qhu.1_Missense_Mutation_p.N1244D|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.N1244D|PCDH15_uc010qhw.1_Missense_Mutation_p.N1207D|PCDH15_uc010qhx.1_Missense_Mutation_p.N1173D|PCDH15_uc010qhy.1_Missense_Mutation_p.N1249D|PCDH15_uc010qhz.1_Missense_Mutation_p.N1244D|PCDH15_uc010qia.1_Missense_Mutation_p.N1222D|PCDH15_uc010qib.1_Missense_Mutation_p.N1222D	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1244	Cadherin 11.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCAGCTGATTGACCACGGAG	0.353			NA								HNSCC(58;0.16)			16	68					0	0	0.003163	0	0
PCDH15	65217	broad.mit.edu	37	10	56138692	56138692	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:56138692C>G	uc001jju.1	-	4	563	c.168G>C	c.(166-168)CTG>CTC	p.L56L	PCDH15_uc010qhq.1_Silent_p.L61L|PCDH15_uc010qhr.1_Silent_p.L56L|PCDH15_uc010qhs.1_Silent_p.L61L|PCDH15_uc010qht.1_Silent_p.L56L|PCDH15_uc010qhu.1_Silent_p.L56L|PCDH15_uc001jjv.1_Silent_p.L34L|PCDH15_uc010qhv.1_Silent_p.L56L|PCDH15_uc010qhw.1_Silent_p.L56L|PCDH15_uc010qhx.1_Silent_p.L56L|PCDH15_uc010qhy.1_Silent_p.L61L|PCDH15_uc010qhz.1_Silent_p.L56L|PCDH15_uc010qia.1_Silent_p.L34L|PCDH15_uc010qib.1_Silent_p.L34L|PCDH15_uc001jjw.2_Silent_p.L56L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	56	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTTGTCCACCAGAATTGTAC	0.428			NA								HNSCC(58;0.16)			53	213					0	0	0.00361	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413889	61413889	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:61413889C>T	uc010qig.1	-	5	1344	c.895G>A	c.(895-897)GCT>ACT	p.A299T		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	299	Extracellular (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity	p.A299A(1)		skin(2)|ovary(1)	3						TTAAAAAGAGCCACAGTTTCA	0.368			NA											58	76					0	0	0.00361	0	0
COL13A1	1305	broad.mit.edu	37	10	71681686	71681686	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:71681686C>A	uc001jpr.1	+	20	1641	c.1105C>A	c.(1105-1107)CAG>AAG	p.Q369K	COL13A1_uc001jqj.1_Missense_Mutation_p.Q369K|COL13A1_uc001jps.1_Missense_Mutation_p.Q340K|COL13A1_uc001jpt.1_Missense_Mutation_p.Q328K|COL13A1_uc001jpu.1_Missense_Mutation_p.Q350K|COL13A1_uc001jpv.1_Missense_Mutation_p.Q369K|COL13A1_uc001jpx.1_Missense_Mutation_p.Q347K|COL13A1_uc001jpw.1_Missense_Mutation_p.Q316K|COL13A1_uc001jpy.1_Missense_Mutation_p.Q307K|COL13A1_uc001jpz.1_Missense_Mutation_p.Q312K|COL13A1_uc001jqa.1_Missense_Mutation_p.Q309K|COL13A1_uc001jqc.1_Missense_Mutation_p.Q369K|COL13A1_uc001jqb.1_Missense_Mutation_p.Q318K|COL13A1_uc001jql.2_Missense_Mutation_p.Q369K|COL13A1_uc001jqd.1_Missense_Mutation_p.Q357K|COL13A1_uc001jqe.1_Missense_Mutation_p.Q352K|COL13A1_uc001jqf.1_Missense_Mutation_p.Q350K|COL13A1_uc001jqg.1_Missense_Mutation_p.Q347K|COL13A1_uc001jqh.1_Missense_Mutation_p.Q369K|COL13A1_uc001jqi.1_Missense_Mutation_p.Q369K|COL13A1_uc010qjf.1_Missense_Mutation_p.Q159K|COL13A1_uc001jqk.1_Missense_Mutation_p.Q207K	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	369	Extracellular (Potential).|Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	CCTCCTGGGGCAGAAGGTAGG	0.597			NA											14	13					1.49906e-05	1.57289e-05	0.00245	1	0
PRF1	5551	broad.mit.edu	37	10	72360567	72360567	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:72360567C>T	uc009xqg.2	-	2	253	c.92G>A	c.(91-93)TGC>TAC	p.C31Y	PRF1_uc001jrf.3_Missense_Mutation_p.C31Y	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	31	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GCTGCGCTTGCACTCTGAGCG	0.682			NA	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				24	20					0	0	0.004656	0	0
DNAJC9	23234	broad.mit.edu	37	10	75005739	75005739	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:75005739G>A	uc001jtr.2	-	3	595	c.517C>T	c.(517-519)CCA>TCA	p.P173S	DNAJC9_uc010qkg.1_Missense_Mutation_p.P173S	NM_015190	NP_056005	Q8WXX5	DNJC9_HUMAN	DnaJ homolog, subfamily C, member 9	173					protein folding		heat shock protein binding|unfolded protein binding				0	Prostate(51;0.0119)					TTATAGGATGGGACCTCTCCG	0.393			NA											42	125					0	0	0.00874	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75407041	75407041	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:75407041G>C	uc001jut.3	-	4	2521	c.2369C>G	c.(2368-2370)TCT>TGT	p.S790C	SYNPO2L_uc001jus.3_Missense_Mutation_p.S566C	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	790	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					CGGGGTAGGAGAAGGACTTCT	0.592			NA											56	280					0	0	0.00361	0	0
MYST4	23522	broad.mit.edu	37	10	76788408	76788408	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:76788408C>T	uc001jwn.1	+	18	4319	c.3826C>T	c.(3826-3828)CCG>TCG	p.P1276S	MYST4_uc001jwo.1_Missense_Mutation_p.P984S|MYST4_uc001jwp.1_Missense_Mutation_p.P1093S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1276					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TTTGTACACCCCGCCAGAAAC	0.483			NA	T	CREBBP	AML								25	111					0	0	0.00333	0	0
LRIT2	340745	broad.mit.edu	37	10	85984343	85984344	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:85984343_85984344TG>CT	uc001kcy.2	-	2	645_646	c.637_638CA>AG	c.(637-639)CAG>AGG	p.Q213R	LRIT2_uc010qmc.1_Missense_Mutation_p.Q213R	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	213	LRRCT.					integral to membrane				ovary(2)	2						CTTGACAAACTGGACAAGCCCC	0.559			NA											8	110					0	0	0.004672	0	0
GRID1	2894	broad.mit.edu	37	10	87362310	87362310	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:87362310G>C	uc001kdl.1	-	16	2851	c.2750C>G	c.(2749-2751)ACA>AGA	p.T917R	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.T488R|uc001kdk.1_Intron	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	917	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GTACTCCCGTGTCGGCTCCAA	0.612			NA								Multiple Myeloma(13;0.14)			10	58					0	0	0.006214	0	0
OPN4	94233	broad.mit.edu	37	10	88419123	88419123	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:88419123G>T	uc001kdq.2	+	5	925	c.698G>T	c.(697-699)CGT>CTT	p.R233L	OPN4_uc001kdp.2_Missense_Mutation_p.R244L|OPN4_uc010qmk.1_Missense_Mutation_p.R244L|OPN4_uc009xsx.1_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	233	Extracellular (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CCGGCCGTGCGTGCCTACACC	0.592			NA											40	123					5.48756e-27	7.52141e-27	0.011902	1	0
IFIT1B	439996	broad.mit.edu	37	10	91144305	91144305	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:91144305C>T	uc001kgh.2	+	2	1315	c.1235C>T	c.(1234-1236)TCC>TTC	p.S412F	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	412	TPR 7.						binding				0						GAAAAAATGTCCCATTCCAGG	0.383			NA											72	81					0	0	0.00361	0	0
ANKRD1	27063	broad.mit.edu	37	10	92679928	92679928	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:92679928C>T	uc001khe.1	-	2	453	c.205G>A	c.(205-207)GAG>AAG	p.E69K		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	69	Potential.				cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)				GCTCTCACCTCTGCCTCTCGT	0.502			NA											56	192					0	0	0.00361	0	0
PIPSL	266971	broad.mit.edu	37	10	95720628	95720628	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:95720628G>A	uc009xuj.2	-	1	1045	c.526C>T	c.(526-528)CTG>TTG	p.L176L		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						ACACAGTACAGTCCATAGAAT	0.433			NA											16	156					0	0	0.008871	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98380134	98380134	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:98380134C>T	uc001kmq.2	-	12	2044	c.1916G>A	c.(1915-1917)CGA>CAA	p.R639Q	PIK3AP1_uc001kmo.2_Missense_Mutation_p.R238Q|PIK3AP1_uc001kmp.2_Missense_Mutation_p.R461Q	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	639						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GGACTCCGATCGTTTCTTCTG	0.383			NA											154	166					0	0	0.00361	0	0
HPS1	3257	broad.mit.edu	37	10	100189563	100189563	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:100189563C>T	uc010qpf.1	-	9	1098	c.852G>A	c.(850-852)GGG>GGA	p.G284G	HPS1_uc001kpi.1_Silent_p.G284G|HPS1_uc001kpj.1_Intron|HPS1_uc001kpk.1_Intron|HPS1_uc009xwb.2_Intron|HPS1_uc010qph.1_Silent_p.G284G|HPS1_uc001kpl.2_Silent_p.G284G	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	284					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CTGCAGAGCTCCCCCCAGTTG	0.692			NA							Hermansky-Pudlak_syndrome				33	152					0	0	0.007835	0	0
BTRC	8945	broad.mit.edu	37	10	103294514	103294514	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:103294514C>T	uc001kta.2	+	10	1307	c.1194C>T	c.(1192-1194)ACC>ACT	p.T398T	BTRC_uc001ktb.2_Silent_p.T362T|BTRC_uc001ktc.2_Silent_p.T372T	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	398	WD 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		TGATGGTGACCTGCTCCAAAG	0.493			NA											13	293					0	0	0.00245	0	0
KCNIP2	30819	broad.mit.edu	37	10	103588945	103588945	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:103588945C>T	uc001kub.2	-	4	587	c.235G>A	c.(235-237)GAT>AAT	p.D79N	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_5'UTR|KCNIP2_uc001ktz.2_Missense_Mutation_p.D34N|KCNIP2_uc009xwu.2_Missense_Mutation_p.D29N|KCNIP2_uc009xwv.2_Missense_Mutation_p.D29N|KCNIP2_uc001kuc.2_Missense_Mutation_p.D94N|KCNIP2_uc001kue.2_Missense_Mutation_p.D61N|KCNIP2_uc001kud.2_Missense_Mutation_p.D29N|KCNIP2_uc001kuf.2_Missense_Mutation_p.D29N|KCNIP2_uc001kua.2_5'UTR|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.D34N|KCNIP2_uc010qqi.1_Missense_Mutation_p.D29N	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	79					clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		TCAAATTCATCGTCCACGCTG	0.632			NA											4	34					0	0	0.009096	0	0
ACTR1A	10121	broad.mit.edu	37	10	104241875	104241875	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:104241875C>T	uc001kvv.2	-	8	916	c.808G>A	c.(808-810)GAG>AAG	p.E270K	ACTR1A_uc010qqn.1_Missense_Mutation_p.E196K|ACTR1A_uc010qqo.1_Missense_Mutation_p.E223K	NM_005736	NP_005727	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A,	270					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)	1		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TCACTCTCCTCTCCAATCAAA	0.572			NA											48	221					0	0	0.00361	0	0
CALHM1	255022	broad.mit.edu	37	10	105215366	105215366	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:105215366C>A	uc001kxe.2	-	2	834	c.694G>T	c.(694-696)GAC>TAC	p.D232Y	CALHM2_uc001kxd.1_5'Flank	NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	232						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						CACGTCTCGTCGAAGAGCTTG	0.602			NA											53	34					5.76465e-13	6.74953e-13	0.00361	1	0
NEURL	9148	broad.mit.edu	37	10	105330648	105330648	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:105330648C>T	uc001kxh.2	+	2	515	c.105C>T	c.(103-105)TTC>TTT	p.F35F		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	35					nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GGGGCCCCTTCCCCGTCACTT	0.652			NA											19	403					0	0	0.007413	0	0
NEURL	9148	broad.mit.edu	37	10	105330828	105330828	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:105330828C>G	uc001kxh.2	+	2	695	c.285C>G	c.(283-285)TTC>TTG	p.F95L		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	95	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CCATCACCTTCAGCAACCGCC	0.652			NA											4	103					0	0	0.009096	0	0
SORCS1	114815	broad.mit.edu	37	10	108367034	108367034	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:108367034G>C	uc001kym.2	-	23	3063	c.3055C>G	c.(3055-3057)CAC>GAC	p.H1019D	SORCS1_uc001kyl.2_Missense_Mutation_p.H1019D|SORCS1_uc009xxs.2_Missense_Mutation_p.H1019D|SORCS1_uc001kyn.1_Missense_Mutation_p.H1019D|SORCS1_uc001kyo.2_Missense_Mutation_p.H1019D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1019	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACCAGGATGTGCTGGCCTGGA	0.547			NA											21	61					0	0	0.010504	0	0
ADRA2A	150	broad.mit.edu	37	10	112838931	112838931	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:112838931G>T	uc001kzo.2	+	1	2142	c.1177G>T	c.(1177-1179)GTG>TTG	p.V393L		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	378	Helical; Name=6; (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CGTGCTGGCCGTGGTCATCGG	0.677	Esophageal Squamous(173;605 2658 7278 49362)		NA											27	92					7.38237e-10	8.33493e-10	0.00632	1	0
AFAP1L2	84632	broad.mit.edu	37	10	116061184	116061184	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:116061184C>T	uc001lbn.2	-	13	1772	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	AFAP1L2_uc001lbo.2_Missense_Mutation_p.D491N|AFAP1L2_uc010qse.1_Missense_Mutation_p.D544N|AFAP1L2_uc001lbp.2_Missense_Mutation_p.D519N|AFAP1L2_uc001lbr.1_Missense_Mutation_p.D491N|AFAP1L2_uc001lbm.2_Missense_Mutation_p.D13N|AFAP1L2_uc010qsd.1_Missense_Mutation_p.D57N|AFAP1L2_uc001lbq.1_Missense_Mutation_p.D13N	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	491					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GGCAGGCCATCGATGTAAGTG	0.612			NA											28	99					0	0	0.003271	0	0
ATRNL1	26033	broad.mit.edu	37	10	117075071	117075071	+	Silent	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:117075071A>G	uc001lcg.2	+	18	3248	c.2862A>G	c.(2860-2862)GAA>GAG	p.E954E	ATRNL1_uc010qsm.1_Silent_p.E129E|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	954	PSI 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTGTTTGGAACAGCCTGGAT	0.418			NA											51	70					0	0	0.00361	0	0
GFRA1	2674	broad.mit.edu	37	10	117853292	117853292	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:117853292C>A	uc001lcj.2	-	8	1634	c.936G>T	c.(934-936)TGG>TGT	p.W312C	GFRA1_uc001lci.2_Missense_Mutation_p.W307C|GFRA1_uc009xyr.2_Missense_Mutation_p.W307C	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	312	3.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGCAGTCACACCATGGGGCCA	0.393	Ovarian(128;329 1725 45498 46808 50759)		NA											18	84					5.01169e-05	5.2361e-05	0.00499	1	0
TACC2	10579	broad.mit.edu	37	10	123844559	123844559	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:123844559G>T	uc001lfv.2	+	4	2904	c.2544G>T	c.(2542-2544)CAG>CAT	p.Q848H	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.Q848H|TACC2_uc010qtv.1_Missense_Mutation_p.Q848H	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	848						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCAAGGAGCAGGCCCAGCCAC	0.532			NA											79	104					7.63117e-38	1.10958e-37	0.00361	1	0
C10orf120	399814	broad.mit.edu	37	10	124457976	124457976	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:124457976G>C	uc001lgn.2	-	3	313	c.281C>G	c.(280-282)GCA>GGA	p.A94G		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	94										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				AAGCCTTCTTGCTGCTATGGT	0.463			NA											242	280					0	0	0.00361	0	0
BCCIP	56647	broad.mit.edu	37	10	127512263	127512263	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr10:127512263A>G	uc001ljb.3	+	1	160	c.137A>G	c.(136-138)AAG>AGG	p.K46R	BCCIP_uc001ljd.3_Missense_Mutation_p.K46R|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.K46R|BCCIP_uc001ljc.3_Missense_Mutation_p.K46R|BCCIP_uc010quj.1_Missense_Mutation_p.K46R	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	46					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				gacaaggaaaaggatgaagag	0.328			NA											3	132					0	0	0.004672	0	0
B4GALNT4	338707	broad.mit.edu	37	11	375893	375893	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:375893C>A	uc001lpb.2	+	11	1041	c.1032C>A	c.(1030-1032)TGC>TGA	p.C344*		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	344	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGAGCCCTGCGCCTACGCCC	0.602			NA											7	28					2.7689e-08	3.04547e-08	0.001984	1	0
B4GALNT4	338707	broad.mit.edu	37	11	379880	379880	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:379880C>A	uc001lpb.2	+	16	2512	c.2503C>A	c.(2503-2505)CGG>AGG	p.R835R		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	835	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAACCAGGCACGGTGGGTGGC	0.642			NA											12	37					7.93312e-07	8.58108e-07	0.00245	1	0
B4GALNT4	338707	broad.mit.edu	37	11	379894	379894	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:379894G>A	uc001lpb.2	+	16	2526	c.2517G>A	c.(2515-2517)CAG>CAA	p.Q839Q		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	839	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGTGGCACAGTTCCTGGCGG	0.657			NA											14	41					0	0	0.004007	0	0
B4GALNT4	338707	broad.mit.edu	37	11	379903	379903	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:379903G>A	uc001lpb.2	+	16	2535	c.2526G>A	c.(2524-2526)GCG>GCA	p.A842A		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	842	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTTCCTGGCGGACATGGCTG	0.677			NA											15	43					0	0	0.00499	0	0
EPS8L2	64787	broad.mit.edu	37	11	720113	720113	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:720113G>T	uc001lqt.2	+	5	464	c.217G>T	c.(217-219)GAC>TAC	p.D73Y	EPS8L2_uc010qwj.1_Missense_Mutation_p.D73Y|EPS8L2_uc001lqu.2_Missense_Mutation_p.D73Y|EPS8L2_uc010qwk.1_Missense_Mutation_p.D73Y|EPS8L2_uc001lqv.2_Missense_Mutation_p.D28Y|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	73	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTCTGTGGACGACGCCATCCG	0.612			NA											18	44					6.94344e-10	7.84841e-10	0.006122	1	0
MUC6	4588	broad.mit.edu	37	11	1017204	1017204	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:1017204G>C	uc001lsw.2	-	31	5648	c.5597C>G	c.(5596-5598)TCT>TGT	p.S1866C		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1866	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GATGGAGGCAGAAGTGGCCAT	0.572			NA											14	544					0	0	0.010729	0	0
OR52R1	119695	broad.mit.edu	37	11	4825658	4825658	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:4825658G>A	uc010qym.1	-	1	190	c.190C>T	c.(190-192)CTG>TTG	p.L64L		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	Error:Variant_position_missing_in_Q8NGF1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTCTCTGCAGATGATAACAA	0.408			NA											36	87					0	0	0.00623	0	0
OR51G2	81282	broad.mit.edu	37	11	4936269	4936269	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:4936269C>A	uc001lzr.1	-	1	625	c.625G>T	c.(625-627)GTC>TTC	p.V209F		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGTAGAGACGATGACAAAC	0.512			NA											25	40					5.35047e-06	5.68089e-06	0.00333	1	0
OR51G1	79324	broad.mit.edu	37	11	4944910	4944910	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:4944910G>T	uc010qyr.1	-	1	660	c.660C>A	c.(658-660)TAC>TAA	p.Y220*		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATGAGGGCGTATGAGAGAA	0.547			NA											53	71					4.86159e-25	6.52652e-25	0.00361	1	0
OR51G1	79324	broad.mit.edu	37	11	4944978	4944978	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:4944978G>T	uc010qyr.1	-	1	592	c.592C>A	c.(592-594)CAC>AAC	p.H198N		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATAGATGTGATTGACAATG	0.532			NA											43	82					1.8453e-21	2.39522e-21	0.010771	1	0
UBQLN3	50613	broad.mit.edu	37	11	5529609	5529609	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:5529609G>T	uc001may.1	-	2	1266	c.1180C>A	c.(1180-1182)CAG>AAG	p.Q394K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	394										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAGAGGCTGGCCTGACCCA	0.577	Ovarian(72;684 1260 12332 41642 52180)		NA											42	222					1.61863e-15	1.97787e-15	0.00361	1	0
ARFIP2	23647	broad.mit.edu	37	11	6501223	6501223	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:6501223C>G	uc001mdk.2	-	3	312	c.175G>C	c.(175-177)GGT>CGT	p.G59R	ARFIP2_uc001mdl.2_Missense_Mutation_p.G59R|ARFIP2_uc010ral.1_Missense_Mutation_p.G21R|ARFIP2_uc010ram.1_Silent_p.L4L|ARFIP2_uc010ran.1_Missense_Mutation_p.G59R|ARFIP2_uc001mdm.2_RNA|ARFIP2_uc009yfe.1_Missense_Mutation_p.G59R|FXC1_uc001mdn.3_5'Flank|FXC1_uc001mdo.3_5'Flank	NM_012402	NP_036534	P53365	ARFP2_HUMAN	ADP-ribosylation factor interacting protein 2	59					actin cytoskeleton organization|cellular component movement|lamellipodium assembly|ruffle organization|small GTPase mediated signal transduction	cell cortex|plasma membrane|ruffle	GTP binding|GTP-dependent protein binding|Rac GTPase binding				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.41e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTCCATCACCAGAGCCCCCA	0.527	Melanoma(119;796 1674 9049 20480 24794)		NA											46	270					0	0	0.00361	0	0
DCHS1	8642	broad.mit.edu	37	11	6653736	6653736	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:6653736G>T	uc001mem.1	-	6	3417	c.3007C>A	c.(3007-3009)CCT>ACT	p.P1003T		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1003	Cadherin 10.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGGTAGGTAGGGCTGTTGAAT	0.642			NA											6	10					0.00116845	0.00119778	0.001168	1	0
DCHS1	8642	broad.mit.edu	37	11	6661762	6661762	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:6661762G>T	uc001mem.1	-	2	1493	c.1083C>A	c.(1081-1083)TCC>TCA	p.S361S		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	361	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGACAGTCATGGAGGGCTGAT	0.582			NA											55	127					2.41709e-19	3.05251e-19	0.00361	1	0
OR2AG1	144125	broad.mit.edu	37	11	6806516	6806516	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:6806516C>A	uc001mer.1	+	1	248	c.248C>A	c.(247-249)GCG>GAG	p.A83E		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAGGCCCTTGCGGACTTTCTG	0.572			NA											75	130					5.41795e-27	7.44684e-27	0.00361	1	0
OR10A5	144124	broad.mit.edu	37	11	6867170	6867170	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:6867170T>A	uc001met.1	+	1	257	c.257T>A	c.(256-258)CTG>CAG	p.L86Q		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGGGGACCCTGCTTGCCCAG	0.502	Pancreas(44;21 1072 25662 28041 45559)		NA											78	135					0	0	0.00361	0	0
NLRP10	338322	broad.mit.edu	37	11	7982771	7982771	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:7982771G>T	uc001mfv.1	-	2	405	c.388C>A	c.(388-390)CCC>ACC	p.P130T		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	130							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTGAGCTGGGCTTGGCCACC	0.562			NA											47	91					1.23103e-26	1.6779e-26	0.013114	1	0
MUC15	143662	broad.mit.edu	37	11	26586850	26586850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:26586850C>A	uc001mqx.2	-	2	822	c.556G>T	c.(556-558)GAA>TAA	p.E186*	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Nonsense_Mutation_p.E213*|MUC15_uc001mqy.2_Nonsense_Mutation_p.E213*	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	186	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCACTTGGTTCCACTATCAAG	0.418			NA											42	85					4.32679e-17	5.38787e-17	0.006999	1	0
CCDC34	91057	broad.mit.edu	37	11	27378962	27378962	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:27378962C>T	uc001mrh.1	-	2	540	c.486G>A	c.(484-486)CTG>CTA	p.L162L	CCDC34_uc001mri.1_Silent_p.L162L	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	162	Potential.										0						CTAGAGCTTTCAGTTGCAGCC	0.398			NA											38	82					0	0	0.00874	0	0
KCNA4	3739	broad.mit.edu	37	11	30033093	30033093	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:30033093C>G	uc001msk.2	-	2	2285	c.1133G>C	c.(1132-1134)TGT>TCT	p.C378S		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	378	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCATACAATACAGACTGTTTC	0.458			NA											43	72					0	0	0.009718	0	0
C11orf41	25758	broad.mit.edu	37	11	33581407	33581407	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:33581407C>T	uc001mup.3	+	6	3219	c.3095C>T	c.(3094-3096)GCT>GTT	p.A1032V	C11orf41_uc001mun.1_Missense_Mutation_p.A1032V	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1026						integral to membrane				ovary(2)	2						CAGCTCTCGGCTGAGCTGGTG	0.592			NA											73	205					0	0	0.00361	0	0
FJX1	24147	broad.mit.edu	37	11	35640940	35640940	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:35640940G>T	uc001mwh.2	+	1	1206	c.756G>T	c.(754-756)GTG>GTT	p.V252V		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	252						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				TCACGGACGTGGTGGTGCCCG	0.746	Melanoma(161;10 2587 27165 47356)		NA											10	19					1.33987e-11	1.55026e-11	0.008291	1	0
ACCS	84680	broad.mit.edu	37	11	44104832	44104832	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:44104832G>T	uc009yks.1	+	13	1369	c.1225G>T	c.(1225-1227)GGC>TGC	p.G409C	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Missense_Mutation_p.G409C	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	409							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						TCGTGGGGCTGGCTTCTTCAT	0.582	Esophageal Squamous(158;148 1889 8077 23160 41213)		NA											32	89					1.06801e-11	1.23718e-11	0.009535	1	0
PEX16	9409	broad.mit.edu	37	11	45937052	45937052	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:45937052G>A	uc001nbu.2	-	5	739	c.427C>T	c.(427-429)CCA>TCA	p.P143S	PEX16_uc001nbt.2_Missense_Mutation_p.P143S	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1	143	Cytoplasmic (Potential).				ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)		CTGTCCAGTGGAACGATAGGG	0.602			NA											44	72					0	0	0.013114	0	0
RAPSN	5913	broad.mit.edu	37	11	47463472	47463472	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:47463472T>A	uc001nfi.1	-	4	906	c.692A>T	c.(691-693)GAG>GTG	p.E231V	RAPSN_uc001nfj.1_Missense_Mutation_p.E231V|RAPSN_uc009yls.1_Missense_Mutation_p.E231V	NM_005055	NP_005046	Q13702	RAPSN_HUMAN	43 kD receptor-associated protein of the synapse	231	TPR 5.				synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			ovary(1)	1						CTTCATAGACTCCTGCGAGGG	0.662			NA											7	12					0	0	0.001984	0	0
NUP160	23279	broad.mit.edu	37	11	47857258	47857258	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:47857258G>C	uc001ngm.2	-	7	1131	c.1046C>G	c.(1045-1047)TCC>TGC	p.S349C	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	349					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						CATGGTGGGGGAATAAGCAAG	0.458			NA											45	79					0	0	0.00361	0	0
OR4C3	256144	broad.mit.edu	37	11	48347244	48347244	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:48347244G>T	uc010rhv.1	+	1	752	c.752G>T	c.(751-753)AGG>ATG	p.R251M		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TACTCCTTGAGGTCCCACAGT	0.488			NA											34	106					3.67414e-24	4.90553e-24	0.012213	1	0
OR5D14	219436	broad.mit.edu	37	11	55563103	55563104	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55563103_55563104GC>TT	uc010rim.1	+	1	72_73	c.72_73GC>TT	c.(70-75)AAGCTT>AATTTT	p.24_25KL>NF		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	24_25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ATTACCCAAAGCTTCAGATTCC	0.391			NA											56	102					0	0	0.004672	0	0
OR5L1	219437	broad.mit.edu	37	11	55579401	55579401	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55579401G>T	uc001nhw.1	+	1	459	c.459G>T	c.(457-459)ACG>ACT	p.T153T		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TCTGTGGGACGGTGTGTTCTC	0.458			NA											31	246					8.88839e-20	1.12978e-19	0.010818	1	0
OR5D18	219438	broad.mit.edu	37	11	55587802	55587802	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55587802A>T	uc010rin.1	+	1	697	c.697A>T	c.(697-699)AGT>TGT	p.S233C		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GCGTTCAGTCAGTGGGCGCCG	0.493			NA											70	78					0	0	0.00361	0	0
OR5L2	26338	broad.mit.edu	37	11	55595399	55595399	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55595399C>A	uc001nhy.1	+	1	705	c.705C>A	c.(703-705)CAC>CAA	p.H235Q		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				AGAGCAGGCACAAAGCTTTCT	0.493			NA								HNSCC(27;0.073)			68	99					2.19297e-23	2.91207e-23	0.00361	1	0
SPRYD5	84767	broad.mit.edu	37	11	55658693	55658693	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55658693C>A	uc010rip.1	+	7	1036	c.944C>A	c.(943-945)CCT>CAT	p.P315H	SPRYD5_uc010riq.1_Missense_Mutation_p.P172H	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	315	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGATGTGACCCTCAAGATGAT	0.408			NA											47	144					1.81118e-26	2.4618e-26	0.00361	1	0
OR5I1	10798	broad.mit.edu	37	11	55703105	55703105	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55703105G>T	uc010ris.1	-	1	772	c.772C>A	c.(772-774)CTC>ATC	p.L258I		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TAAATAAAGAGGAGAGTCCCT	0.443			NA											10	36					0.00010058	0.000104748	0.001368	1	0
OR8H2	390151	broad.mit.edu	37	11	55873187	55873187	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:55873187T>C	uc010riy.1	+	1	669	c.669T>C	c.(667-669)TTT>TTC	p.F223F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TCATTCTCTTTACCATCCTGA	0.393			NA								HNSCC(53;0.14)			8	175					0	0	0.00308	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57088056	57088056	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:57088056C>A	uc001njr.2	-	2	537	c.225G>T	c.(223-225)TTG>TTT	p.L75F	TNKS1BP1_uc001njs.2_Missense_Mutation_p.L75F|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	75	Arg/Glu/Lys/Pro-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TGGCAGAAGGCAACTCAGCCA	0.677			NA											32	40					4.74835e-14	5.63364e-14	0.010818	1	0
SMTNL1	219537	broad.mit.edu	37	11	57309022	57309023	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:57309022_57309023CC>AA	uc009ymh.1	+	1	44_45	c.44_45CC>AA	c.(43-45)GCC>GAA	p.A15E		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)	1						TCAGCAGAGGCCAGGGAGAGTA	0.51			NA											53	138					0	0	0.004672	0	0
OR4D10	390197	broad.mit.edu	37	11	59245074	59245074	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:59245074C>A	uc001nnz.1	+	1	172	c.172C>A	c.(172-174)CCC>ACC	p.P58T		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CCTTCACACGCCCATGTATTT	0.433			NA											116	247					4.94232e-47	7.41726e-47	0.00361	1	0
OR4D11	219986	broad.mit.edu	37	11	59271114	59271114	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:59271114C>G	uc001noa.1	+	1	66	c.66C>G	c.(64-66)GAC>GAG	p.D22E		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATCCCAAGACCAGAGTTTGG	0.413			NA											43	113					0	0	0.006999	0	0
INCENP	3619	broad.mit.edu	37	11	61897893	61897893	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:61897893G>A	uc001nsw.1	+	4	1096	c.894G>A	c.(892-894)ACG>ACA	p.T298T	INCENP_uc009ynv.2_Silent_p.T298T|INCENP_uc009ynw.1_Silent_p.T298T|INCENP_uc001nsx.1_Silent_p.T298T	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	298					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						GCTCTCGCACGGACTCTCAAT	0.632			NA											119	123					0	0	0.00361	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359265	64359265	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:64359265G>T	uc001oam.1	+	1	984	c.237G>T	c.(235-237)CCG>CCT	p.P79P	SLC22A12_uc009ypr.1_Silent_p.P79P|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Silent_p.P79P|SLC22A12_uc001oan.1_Silent_p.P79P|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	79					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCATCCCGCCGGGCCCCAACC	0.687			NA											11	79					5.16669e-11	5.92205e-11	0.010729	1	0
TM7SF2	7108	broad.mit.edu	37	11	64882807	64882807	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:64882807G>T	uc001oct.2	+	8	1061	c.914G>T	c.(913-915)CGT>CTT	p.R305L	TM7SF2_uc010rny.1_Missense_Mutation_p.R189L|TM7SF2_uc001ocu.2_Intron|TM7SF2_uc001ocv.2_Missense_Mutation_p.R326L|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	305					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TACATCTTCCGTGGGGCGAAT	0.557			NA											21	219					3.62473e-10	4.12093e-10	0.012319	1	0
SPTBN2	6712	broad.mit.edu	37	11	66460452	66460452	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:66460452C>A	uc001ojd.2	-	24	5046	c.4974G>T	c.(4972-4974)GAG>GAT	p.E1658D		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1658	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCTCTGGGTGCTCGTGGTCAA	0.657			NA											542	206					4.45376e-183	7.07404e-183	0.00361	1	0
MOGAT2	80168	broad.mit.edu	37	11	75438495	75438495	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:75438495G>C	uc010rru.1	+	3	286	c.286G>C	c.(286-288)GAG>CAG	p.E96Q	MOGAT2_uc001oww.1_Missense_Mutation_p.E96Q|MOGAT2_uc010rrv.1_Missense_Mutation_p.E14Q	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	96					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CAAGACTGCTGAGCTGGACCC	0.418			NA											6	69					0	0	0.004482	0	0
GAB2	9846	broad.mit.edu	37	11	77934641	77934641	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:77934641G>T	uc001ozh.2	-	6	1384	c.1384C>A	c.(1384-1386)CTG>ATG	p.L462M	GAB2_uc001ozg.2_Missense_Mutation_p.L424M	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	462					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			ATGGCCAACAGGGTGGAAGAA	0.522			NA											97	307					5.25376e-55	8.00729e-55	0.00361	1	0
RAB30	27314	broad.mit.edu	37	11	82705138	82705138	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:82705138G>A	uc001ozu.2	-	4	381	c.120C>T	c.(118-120)GCC>GCT	p.A40A	RAB30_uc009yve.2_Silent_p.A38A|RAB30_uc010rst.1_Silent_p.A38A|RAB30_uc001ozv.2_Silent_p.A38A|RAB30_uc009yvg.1_Intron	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	40	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						CTCCAATTGTGGCTCCTTGAC	0.378			NA											49	86					0	0	0.00361	0	0
TYR	7299	broad.mit.edu	37	11	88961012	88961012	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:88961012G>T	uc001pcs.2	+	3	1140	c.1058G>T	c.(1057-1059)GGG>GTG	p.G353V		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	353	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CCACTTACTGGGATAGCGGAT	0.373			NA							Oculocutaneous_Albinism				27	54					2.41591e-17	3.0122e-17	0.004656	1	0
CNTN5	53942	broad.mit.edu	37	11	99715877	99715877	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:99715877G>T	uc001pga.2	+	6	799	c.460G>T	c.(460-462)GAT>TAT	p.D154Y	CNTN5_uc009ywv.1_Missense_Mutation_p.D154Y|CNTN5_uc001pfz.2_Missense_Mutation_p.D154Y|CNTN5_uc001pgb.2_Missense_Mutation_p.D80Y	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	154	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CAGTTTGATAGATGGCACCTT	0.383			NA											34	99					6.50621e-10	7.36269e-10	0.002836	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106810187	106810187	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:106810187T>A	uc001pjg.1	-	4	1595	c.1205A>T	c.(1204-1206)AAG>ATG	p.K402M	GUCY1A2_uc010rvo.1_Missense_Mutation_p.K402M|GUCY1A2_uc009yxn.1_Missense_Mutation_p.K402M	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	402					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AGCACTTACCTTGTCTTTATT	0.423			NA											29	137					0	0	0.009535	0	0
EXPH5	23086	broad.mit.edu	37	11	108380380	108380380	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:108380380G>C	uc001pkk.2	-	6	5965	c.5854C>G	c.(5854-5856)CCA>GCA	p.P1952A	EXPH5_uc010rvy.1_Missense_Mutation_p.P1764A|EXPH5_uc010rvz.1_Missense_Mutation_p.P1796A|EXPH5_uc010rwa.1_Missense_Mutation_p.P1876A	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1952					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGTTCACTTGGAGATAAGCCA	0.448			NA											9	123					0	0	0.004482	0	0
NCAM1	4684	broad.mit.edu	37	11	113103515	113103515	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:113103515G>A	uc009yyq.1	+	13	1919	c.1225G>A	c.(1225-1227)GAA>AAA	p.E409K		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	501	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GGAGTCCTTGGAATTCATCCT	0.502			NA											20	60					0	0	0.007413	0	0
HTR3B	9177	broad.mit.edu	37	11	113780085	113780085	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:113780085C>A	uc001pok.2	+	2	188	c.121C>A	c.(121-123)CAG>AAG	p.Q41K	HTR3B_uc001pol.2_Missense_Mutation_p.Q30K	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	41	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GCAGCTATTACAGAAATATCA	0.418			NA											23	98					1.10923e-09	1.24519e-09	0.00278	1	0
DSCAML1	57453	broad.mit.edu	37	11	117389416	117389416	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:117389416G>T	uc001prh.1	-	7	1457	c.1455C>A	c.(1453-1455)TTC>TTA	p.F485L	DSCAML1_uc001pri.1_Missense_Mutation_p.F289L	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	425	Extracellular (Potential).|Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ACATCAGTGAGAACTGCTCCC	0.677			NA											11	45					9.70103e-10	1.09276e-09	0.008291	1	0
MPZL3	196264	broad.mit.edu	37	11	118122970	118122970	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:118122970G>A	uc001psm.2	-	1	42	c.40C>T	c.(40-42)CTC>TTC	p.L14F	MPZL3_uc010rxy.1_Missense_Mutation_p.L14F|MPZL3_uc010rxz.1_RNA|MPZL3_uc009yzy.2_RNA	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor	14					cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AGAGGGAAGAGAGCGCAGCCA	0.612			NA											11	137					0	0	0.001368	0	0
BCL9L	283149	broad.mit.edu	37	11	118773142	118773142	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:118773142C>A	uc001pug.2	-	6	2275	c.1310G>T	c.(1309-1311)GGA>GTA	p.G437V	BCL9L_uc009zal.2_Missense_Mutation_p.G432V	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	437	Pro-rich.|Necessary for interaction with CTNNB1 (By similarity).				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CTCACCCGCTCCTCCTGGGGG	0.682			NA											22	35					1.87028e-06	1.99877e-06	0.012319	1	0
C11orf63	79864	broad.mit.edu	37	11	122830098	122830098	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:122830098G>C	uc001pym.2	+	9	2579	c.2282G>C	c.(2281-2283)AGA>ACA	p.R761T		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	761										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CTGCAGAACAGACACGAAAGG	0.408			NA											3	67					0	0	0.004672	0	0
OR8D1	283159	broad.mit.edu	37	11	124179778	124179778	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:124179778C>A	uc010sag.1	-	1	885	c.885G>T	c.(883-885)AAG>AAT	p.K295N		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TCTTCACATCCTTATTCCTCA	0.418			NA											23	80					1.87028e-06	1.99877e-06	0.012319	1	0
OR8D1	283159	broad.mit.edu	37	11	124180649	124180649	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:124180649T>A	uc010sag.1	-	1	14	c.14A>T	c.(13-15)AAT>ATT	p.N5I		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CATAGAATAATTTTCCATGGT	0.418			NA											15	108					0	0	0.004007	0	0
OR8B4	283162	broad.mit.edu	37	11	124294248	124294248	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:124294248C>A	uc010sak.1	-	1	520	c.520G>T	c.(520-522)GAC>TAC	p.D174Y		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGATAATGGTCAATGACGTTG	0.502			NA											14	26					9.31168e-06	9.82287e-06	0.001855	1	0
ROBO4	54538	broad.mit.edu	37	11	124763875	124763875	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:124763875C>T	uc001qbg.2	-	9	1525	c.1385G>A	c.(1384-1386)AGG>AAG	p.R462K	ROBO4_uc010sas.1_Missense_Mutation_p.R317K|ROBO4_uc001qbh.2_Missense_Mutation_p.R352K|ROBO4_uc001qbi.2_Missense_Mutation_p.R20K|ROBO4_uc010sat.1_Missense_Mutation_p.R20K	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	462					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CAAGGTAGCCCTCAGCTGCTC	0.642			NA											6	16					0	0	0.001168	0	0
HEPACAM	220296	broad.mit.edu	37	11	124793277	124793277	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:124793277C>A	uc001qbk.2	-	4	1168	c.762G>T	c.(760-762)GTG>GTT	p.V254V	HEPACAM_uc009zbj.2_5'UTR|HEPACAM_uc001qbl.1_Silent_p.V254V	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	254	Helical; (Potential).				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TCACCAAGGTCACAAGGAGGA	0.522			NA											73	112					4.37588e-27	6.02298e-27	0.00361	1	0
NTM	50863	broad.mit.edu	37	11	132204977	132204977	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:132204977G>C	uc001qgp.2	+	7	1636	c.972G>C	c.(970-972)TCG>TCC	p.S324S	NTM_uc001qgm.2_Silent_p.S324S|NTM_uc010sch.1_Silent_p.S326S|NTM_uc010sci.1_Silent_p.S335S|NTM_uc010scj.1_Silent_p.S283S|NTM_uc001qgq.2_Silent_p.S335S|NTM_uc001qgr.2_Silent_p.S106S	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	324					cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						ACGGCACGTCGAGGAGGGCAG	0.607			NA											36	162					0	0	0.006999	0	0
OPCML	4978	broad.mit.edu	37	11	132399049	132399049	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:132399049G>A	uc001qgs.2	-	3	482	c.432C>T	c.(430-432)GAC>GAT	p.D144D	OPCML_uc001qgu.2_Silent_p.D137D|OPCML_uc010sck.1_Silent_p.D144D|OPCML_uc001qgt.2_Silent_p.D144D|OPCML_uc010scl.1_Silent_p.D103D	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	144	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCACAGTGATGTCTGAGGAGA	0.453			NA											17	47					0	0	0.004007	0	0
ACAD8	27034	broad.mit.edu	37	11	134132438	134132438	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:134132438C>T	uc001qhk.2	+	10	1178	c.1117C>T	c.(1117-1119)CAC>TAC	p.H373Y	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.H296Y|ACAD8_uc001qhl.2_Missense_Mutation_p.H246Y	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	373	FAD; shared with dimeric partner.				branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CTTGCAGATGCACGGGGGCTA	0.552	GBM(65;238 1125 33403 41853 48889)		NA									OREG0021549	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	28					0	0	0.006122	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457372	6457372	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:6457372G>A	uc001qnx.2	-	13	1966	c.1677C>T	c.(1675-1677)TTC>TTT	p.F559F	SCNN1A_uc001qnv.2_Silent_p.F259F|SCNN1A_uc001qnw.2_Silent_p.F618F|SCNN1A_uc010sfb.1_Silent_p.F582F	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	559	Helical; (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CCGAGGAGCCGAACCACAGGC	0.567			NA											23	117					0	0	0.00333	0	0
NCAPD2	9918	broad.mit.edu	37	12	6635486	6635486	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:6635486C>T	uc001qoo.2	+	20	2561	c.2515C>T	c.(2515-2517)CTG>TTG	p.L839L	NCAPD2_uc009zen.1_Silent_p.L711L|NCAPD2_uc010sfd.1_Silent_p.L794L	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	839					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						CCCCTTCCGGCTGCCTCAGGA	0.562			NA											80	48					0	0	0.00361	0	0
DUSP16	80824	broad.mit.edu	37	12	12629939	12629939	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:12629939G>A	uc001rao.1	-	7	2458	c.1826C>T	c.(1825-1827)TCG>TTG	p.S609L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S461L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	609					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GCTCCGCCGCGAGTCAGCTCT	0.542	Ovarian(158;443 1896 15437 36069 46477)		NA											12	216					0	0	0.010729	0	0
PLCZ1	89869	broad.mit.edu	37	12	18889244	18889244	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:18889244C>A	uc010sid.1	-	3	237	c.46G>T	c.(46-48)GGT>TGT	p.G16C	PLCZ1_uc001rdv.3_Translation_Start_Site|PLCZ1_uc001rdw.3_Translation_Start_Site|CAPZA3_uc001rdy.2_5'Flank	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	16					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					ATTTTTCCACCTCTGAAGTCA	0.303			NA											14	46					0.000219431	0.0002278	0.00245	1	0
SOX5	6660	broad.mit.edu	37	12	23757416	23757416	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:23757416G>C	uc001rfw.2	-	9	1171	c.1069C>G	c.(1069-1071)CTG>GTG	p.L357V	SOX5_uc001rfx.2_Missense_Mutation_p.L344V|SOX5_uc001rfy.2_Missense_Mutation_p.L344V|SOX5_uc010siv.1_Missense_Mutation_p.L344V|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.L309V	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	357					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ATGCCTGGCAGCTTCCCTCCT	0.488			NA											31	74					0	0	0.004878	0	0
OVCH1	341350	broad.mit.edu	37	12	29649551	29649551	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:29649551A>C	uc001rix.1	-	2	121	c.121T>G	c.(121-123)TCT>GCT	p.S41A		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	41	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AAGAATCTAGATCCCACGGCA	0.428			NA											78	104					0	0	0.00361	0	0
PFKM	5213	broad.mit.edu	37	12	48527166	48527166	+	Missense_Mutation	SNP	G	G	A	rs150522604		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:48527166G>A	uc001rrc.2	+	6	666	c.496G>A	c.(496-498)GAC>AAC	p.D166N	PFKM_uc001rra.1_5'UTR|PFKM_uc001rrb.1_Missense_Mutation_p.D237N|PFKM_uc001rrd.2_5'UTR|PFKM_uc001rre.1_Missense_Mutation_p.D166N|PFKM_uc001rrg.1_Missense_Mutation_p.D166N	NM_000289	NP_000280	P08237	K6PF_HUMAN	phosphofructokinase, muscle	166		Proton acceptor (By similarity).			fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4						TGGGTCAATTGACAATGACTT	0.507			NA											33	91					0	0	0.010818	0	0
PRPH	5630	broad.mit.edu	37	12	49691154	49691154	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:49691154C>T	uc001rtu.2	+	6	1086	c.1011C>T	c.(1009-1011)CTC>CTT	p.L337L		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	337	Coil 2.|Rod.						structural molecule activity				0						AGGCGCTGCTCAGGCAGTTGA	0.662			NA									OREG0021790	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	52					0	0	0.001984	0	0
KRT75	9119	broad.mit.edu	37	12	52827609	52827609	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:52827609G>A	uc001saj.2	-	1	502	c.480C>T	c.(478-480)TTC>TTT	p.F160F		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	160	Coil 1A.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGAAGGAGGCGAACTTATTGT	0.562			NA											28	190					0	0	0.010818	0	0
KRT3	3850	broad.mit.edu	37	12	53186142	53186142	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:53186142G>C	uc001say.2	-	5	1135	c.1069C>G	c.(1069-1071)CTG>GTG	p.L357V		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	357	Rod.|Linker 12.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						TCCATGGACAGCACCACAGAT	0.512			NA											29	29					0	0	0.005524	0	0
CAND1	55832	broad.mit.edu	37	12	67696224	67696224	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:67696224C>T	uc001stn.2	+	8	1559	c.1122C>T	c.(1120-1122)ACC>ACT	p.T374T	CAND1_uc001sto.2_Silent_p.T52T	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	374	HEAT 9.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCTACAAGACCGTCTCTCCTG	0.433			NA											87	53					0	0	0.00361	0	0
YEATS4	8089	broad.mit.edu	37	12	69759413	69759413	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:69759413G>C	uc001sux.2	+	3	393	c.172G>C	c.(172-174)GAT>CAT	p.D58H		NM_006530	NP_006521	O95619	YETS4_HUMAN	glioma-amplified sequence-41	58	YEATS.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			TATATTTTAGGATATGTCAGC	0.269			NA											54	37					0	0	0.00361	0	0
LRRC10	376132	broad.mit.edu	37	12	70003877	70003877	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:70003877C>T	uc001svc.2	-	1	1066	c.742G>A	c.(742-744)GAC>AAC	p.D248N		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	248						nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTTCTAGGGTCGGGCTCTGGC	0.587			NA											24	57					0	0	0.00333	0	0
PTPRR	5801	broad.mit.edu	37	12	71092123	71092123	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:71092123G>T	uc001swi.1	-	8	1617	c.1201C>A	c.(1201-1203)CCA>ACA	p.P401T	PTPRR_uc001swh.1_Missense_Mutation_p.P156T|PTPRR_uc009zrs.2_Missense_Mutation_p.P250T|PTPRR_uc010stq.1_Missense_Mutation_p.P289T|PTPRR_uc010str.1_Missense_Mutation_p.P250T	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	401	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AAGTTCATTGGTATTTCCTGC	0.338			NA											43	17					2.35958e-20	3.03464e-20	0.009718	1	0
NAV3	89795	broad.mit.edu	37	12	78515788	78515788	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:78515788C>T	uc001syp.2	+	16	3991	c.3818C>T	c.(3817-3819)TCA>TTA	p.S1273L	NAV3_uc001syo.2_Missense_Mutation_p.S1273L|NAV3_uc010sub.1_Missense_Mutation_p.S773L|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1273	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAATCTTCCTCAGTAATGCCC	0.527			NA								HNSCC(70;0.22)			7	62					0	0	0.001984	0	0
MGAT4C	25834	broad.mit.edu	37	12	86374139	86374139	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:86374139G>A	uc001tai.3	-	8	1615	c.365C>T	c.(364-366)TCA>TTA	p.S122L	MGAT4C_uc001tal.3_Missense_Mutation_p.S122L|MGAT4C_uc001taj.3_Missense_Mutation_p.S122L|MGAT4C_uc001tak.3_Missense_Mutation_p.S122L|MGAT4C_uc010sum.1_Missense_Mutation_p.S146L|MGAT4C_uc001tah.3_Missense_Mutation_p.S122L	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	122	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						CTCAAAAATTGACTTAATTGT	0.373			NA											10	52					0	0	0.006214	0	0
EPYC	1833	broad.mit.edu	37	12	91371958	91371958	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:91371958C>T	uc001tbk.2	-	3	340	c.247G>A	c.(247-249)GAA>AAA	p.E83K		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	83	Poly-Glu.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						TCCTCCTCTTCCTCTTCCTGG	0.507			NA									OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	117					0	0	0.004007	0	0
CCDC41	51134	broad.mit.edu	37	12	94763742	94763742	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:94763742C>G	uc001tdd.2	-	9	1590	c.1004G>C	c.(1003-1005)AGT>ACT	p.S335T	CCDC41_uc001tde.2_Missense_Mutation_p.S335T|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.S335T	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	327	Potential.										0						TTCTAGCTCACTCTTAGCTCT	0.348			NA											23	225					0	0	0.003954	0	0
MYBPC1	4604	broad.mit.edu	37	12	102074275	102074275	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:102074275C>A	uc001tii.2	+	28	3482	c.3380C>A	c.(3379-3381)ACA>AAA	p.T1127K	MYBPC1_uc001tig.2_Missense_Mutation_p.T1134K|MYBPC1_uc010svq.1_Missense_Mutation_p.T1096K|MYBPC1_uc001tih.2_Missense_Mutation_p.T1134K|MYBPC1_uc001tij.2_Missense_Mutation_p.T1109K|MYBPC1_uc010svr.1_Missense_Mutation_p.T1109K|MYBPC1_uc010svs.1_Missense_Mutation_p.T1127K|MYBPC1_uc010svt.1_Missense_Mutation_p.T1097K|MYBPC1_uc010svu.1_Missense_Mutation_p.T1090K|MYBPC1_uc001tik.2_Missense_Mutation_p.T1083K|MYBPC1_uc001til.2_Missense_Mutation_p.T152K|MYBPC1_uc001tim.2_Missense_Mutation_p.T152K	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	1127	Ig-like C2-type 7.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GACCTTGGGACAGTGGAGATT	0.433			NA											49	40					1.48341e-19	1.88065e-19	0.00361	1	0
FOXN4	121643	broad.mit.edu	37	12	109723185	109723185	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:109723185G>C	uc001toe.3	-	8	930	c.825C>G	c.(823-825)ATC>ATG	p.I275M	FOXN4_uc009zvg.2_Missense_Mutation_p.I72M|FOXN4_uc001tof.3_Missense_Mutation_p.I95M	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	275	Fork-head.				axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						CCATCTTGTCGATGCGGGCCA	0.612			NA											10	37					0	0	0.006214	0	0
MYL2	4633	broad.mit.edu	37	12	111353570	111353570	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:111353570T>A	uc001try.3	-	3	189	c.118A>T	c.(118-120)AGG>TGG	p.R40W	MYL2_uc001trx.3_Missense_Mutation_p.R21W	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	40	|EF-hand 1.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						AAGCCATCCCTGTTCTGGTCC	0.522	GBM(14;268 426 18829 21617 25540)		NA											121	79					0	0	0.00361	0	0
CUX2	23316	broad.mit.edu	37	12	111779639	111779639	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:111779639G>T	uc001tsa.1	+	21	3594	c.3441G>T	c.(3439-3441)CCG>CCT	p.P1147P		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1147						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GTGAGTCCCCGGCCACCCGCT	0.667			NA											69	36					3.07281e-33	4.37062e-33	0.00361	1	0
PTPN11	5781	broad.mit.edu	37	12	112888228	112888228	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:112888228A>G	uc001ttx.2	+	3	624	c.244A>G	c.(244-246)ATG>GTG	p.M82V	PTPN11_uc001ttw.1_Missense_Mutation_p.M82V	NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	82	SH2 1.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						CCAGTATTACATGGAACATCA	0.428			NA	Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				78	54					0	0	0.00361	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926751	130926751	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:130926751G>T	uc001uil.2	-	8	1259	c.1095C>A	c.(1093-1095)CGC>CGA	p.R365R	RIMBP2_uc001uim.2_Silent_p.R273R|RIMBP2_uc001uin.1_Silent_p.R24R	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	365	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCACGGAGATGCGGTAGGTGC	0.632			NA											66	23					4.45325e-31	6.22566e-31	0.00361	1	0
POLE	5426	broad.mit.edu	37	12	133208909	133208909	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr12:133208909C>A	uc001uks.1	-	45	6366	c.6322G>T	c.(6322-6324)GTG>TTG	p.V2108L	POLE_uc001ukq.1_Missense_Mutation_p.V318L|POLE_uc001ukr.1_Missense_Mutation_p.V912L|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	2108					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ACCTTGCACACGTATTTGATG	0.532			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					42	23					1.07121e-22	1.411e-22	0.006999	1	0
MIPEP	4285	broad.mit.edu	37	13	24415543	24415543	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:24415543C>A	uc001uox.3	-	11	1291	c.1191G>T	c.(1189-1191)CTG>CTT	p.L397L		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	397					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AAATCCCCAACAGTCTGTTAA	0.473			NA											19	28					1.64113e-05	1.71828e-05	0.010504	1	0
ATP8A2	51761	broad.mit.edu	37	13	26116178	26116178	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:26116178G>A	uc001uqk.2	+	9	915	c.773G>A	c.(772-774)GGG>GAG	p.G258E	ATP8A2_uc010tdi.1_Missense_Mutation_p.G218E|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.G218E	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	218	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AACTTAGATGGGAAAAGGTAT	0.363			NA											15	32					0	0	0.00499	0	0
C13orf33	84935	broad.mit.edu	37	13	31495911	31495911	+	Silent	SNP	C	C	T	rs138341583		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:31495911C>T	uc001uth.3	+	4	1056	c.715C>T	c.(715-717)CTG>TTG	p.L239L	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	239											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		TAAGTTATTTCTGGAAAAAAT	0.373			NA											17	59					0	0	0.007413	0	0
FRY	10129	broad.mit.edu	37	13	32811588	32811588	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:32811588G>A	uc001utx.2	+	44	6379	c.5883G>A	c.(5881-5883)ATG>ATA	p.M1961I	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1961					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AACTAAACATGAACCCGGGAA	0.478			NA											5	112					0	0	0.001168	0	0
NBEA	26960	broad.mit.edu	37	13	35683448	35683448	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:35683448A>G	uc001uvb.2	+	13	1908	c.1702A>G	c.(1702-1704)AGA>GGA	p.R568G		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	568						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCATATAACTAGAGCTGTCCT	0.328			NA											31	123					0	0	0.003271	0	0
EPSTI1	94240	broad.mit.edu	37	13	43469156	43469156	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:43469156C>T	uc001uyw.1	-	11	1013	c.937G>A	c.(937-939)GGT>AGT	p.G313S	EPSTI1_uc001uyx.1_Missense_Mutation_p.G302S	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	313										ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		CAGCTGTTACCGCTATTCATA	0.378			NA											19	75					0	0	0.010504	0	0
C13orf31	144811	broad.mit.edu	37	13	44455682	44455682	+	Silent	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:44455682A>T	uc010acg.2	+	2	1046	c.561A>T	c.(559-561)CCA>CCT	p.P187P	CCDC122_uc010acf.2_5'Flank|C13orf31_uc001uzf.3_Silent_p.P187P	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	187											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)		CTTTGATCCCAGGTATATTAA	0.343			NA											23	56					0	0	0.002299	0	0
NUFIP1	26747	broad.mit.edu	37	13	45517783	45517783	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:45517783C>T	uc001uzp.2	-	9	1207	c.1165G>A	c.(1165-1167)GTT>ATT	p.V389I		NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein	389					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding				0		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		TCTGCCAAAACGTCTGCTTCA	0.333			NA											9	154					0	0	0.008291	0	0
ARL11	115761	broad.mit.edu	37	13	50204848	50204848	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:50204848G>A	uc001vdf.1	+	2	411	c.265G>A	c.(265-267)GAC>AAC	p.D89N		NM_138450	NP_612459	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	89					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		GTACGTGCTGGACAGCACAGA	0.612			NA											8	241					0	0	0.006214	0	0
PCDH17	27253	broad.mit.edu	37	13	58298763	58298763	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:58298763A>G	uc001vhq.1	+	4	3707	c.2815A>G	c.(2815-2817)AAT>GAT	p.N939D	PCDH17_uc010aec.1_Missense_Mutation_p.N938D|PCDH17_uc001vhr.1_Missense_Mutation_p.N28D	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	939	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGAGTGTGTTAATTGCACAGA	0.428	Melanoma(72;952 1291 1619 12849 33676)		NA											19	81					0	0	0.002299	0	0
PCDH9	5101	broad.mit.edu	37	13	66879088	66879088	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:66879088T>G	uc001vik.2	-	5	4105	c.3413A>C	c.(3412-3414)CAC>CCC	p.H1138P	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Missense_Mutation_p.H1104P|PCDH9_uc010thl.1_Missense_Mutation_p.H1096P	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1138	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ATTATCAGAGTGACCCAAAAC	0.493			NA											45	118					0	0	0.010771	0	0
MYCBP2	23077	broad.mit.edu	37	13	77713445	77713445	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:77713445C>T	uc001vkf.2	-	53	7522	c.7431G>A	c.(7429-7431)CTG>CTA	p.L2477L	MYCBP2_uc010aev.2_Silent_p.L1881L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CATTCAGCCTCAGCCACACAC	0.428			NA											26	177					0	0	0.004656	0	0
CLDN10	9071	broad.mit.edu	37	13	96205172	96205172	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:96205172C>T	uc001vmh.2	+	1	226	c.165C>T	c.(163-165)ACC>ACT	p.T55T	CLDN10_uc001vmg.2_Intron|CLDN10_uc010tii.1_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	55	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			CGTGCGTTACCGACTCCACGG	0.647			NA											5	112					0	0	0.001168	0	0
DOCK9	23348	broad.mit.edu	37	13	99534165	99534165	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:99534165C>A	uc001vnt.2	-	24	2714	c.2659G>T	c.(2659-2661)GTC>TTC	p.V887F	DOCK9_uc001vnw.2_Missense_Mutation_p.V886F|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.V887F|DOCK9_uc010tis.1_Missense_Mutation_p.V886F|DOCK9_uc010tit.1_Missense_Mutation_p.V887F|DOCK9_uc010afu.1_Missense_Mutation_p.V733F	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	887					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTAACCGCGACTTCTTCCTGT	0.532			NA											5	18					1.23904e-05	1.30146e-05	0.000602	1	0
NALCN	259232	broad.mit.edu	37	13	101997749	101997749	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:101997749C>A	uc001vox.1	-	7	856	c.667G>T	c.(667-669)GCT>TCT	p.A223S	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.A223S|NALCN_uc001vpa.2_Missense_Mutation_p.A223S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	223	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCTGGAATAGCTAAACTATTC	0.398			NA											54	129					5.57489e-27	7.63044e-27	0.00361	1	0
COL4A2	1284	broad.mit.edu	37	13	111077165	111077165	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:111077165G>A	uc001vqx.2	+	5	554	c.265G>A	c.(265-267)GAC>AAC	p.D89N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	89					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			ACGTAAAGGAGACAAGGGTGA	0.622			NA											48	187					0	0	0.00361	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111862229	111862229	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:111862229G>T	uc001vrs.2	+	5	661	c.411G>T	c.(409-411)CTG>CTT	p.L137L	ARHGEF7_uc001vrr.2_Silent_p.L116L|ARHGEF7_uc001vrt.2_Silent_p.L87L|ARHGEF7_uc010tjn.1_Intron|ARHGEF7_uc001vru.1_5'UTR|ARHGEF7_uc001vrv.3_Intron|ARHGEF7_uc001vrw.3_5'UTR|ARHGEF7_uc001vrx.3_5'UTR|ARHGEF7_uc010tjo.1_Silent_p.L34L	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	137					apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			ACATCGGGCTGGGGAGTGACT	0.527			NA											201	452					8.86189e-83	1.39625e-82	0.00361	1	0
ADPRHL1	113622	broad.mit.edu	37	13	114077292	114077292	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:114077292C>A	uc001vtq.1	-	7	997	c.910G>T	c.(910-912)GAG>TAG	p.E304*	ADPRHL1_uc001vtp.1_Nonsense_Mutation_p.E222*	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	304					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			GCCGCGCTCTCCCCTGAAACG	0.642			NA											52	100					9.16383e-17	1.13248e-16	0.00361	1	0
RASA3	22821	broad.mit.edu	37	13	114782760	114782760	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr13:114782760C>A	uc001vui.2	-	12	1290	c.1159G>T	c.(1159-1161)GCG>TCG	p.A387S	RASA3_uc010tkk.1_Missense_Mutation_p.A355S|RASA3_uc001vuj.2_Missense_Mutation_p.A4S|RASA3_uc010tkl.1_RNA	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	387	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TGCATCCCCGCCAGCTTCATG	0.612			NA									OREG0022538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	178					3.28615e-30	4.58098e-30	0.00361	1	0
OR4Q3	441669	broad.mit.edu	37	14	20216521	20216521	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:20216521C>A	uc010tkt.1	+	1	935	c.935C>A	c.(934-936)CCT>CAT	p.P312H		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTCCATTGCCTTGTTAAGGA	0.393			NA											26	33					4.7796e-09	5.29866e-09	0.004656	1	0
OR4K2	390431	broad.mit.edu	37	14	20344728	20344728	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:20344728T>C	uc001vwh.1	+	1	302	c.302T>C	c.(301-303)ATA>ACA	p.I101T		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTACCCAGATATTCTTTCTC	0.418			NA											92	190					0	0	0.00361	0	0
OR4K17	390436	broad.mit.edu	37	14	20585657	20585657	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:20585657C>A	uc001vwo.1	+	1	92	c.92C>A	c.(91-93)GCC>GAC	p.A31D		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		AGGATGGAGGCCATGAAACTA	0.418			NA											51	137					5.85753e-14	6.93283e-14	0.00361	1	0
LRRC16B	90668	broad.mit.edu	37	14	24534852	24534852	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:24534852G>C	uc001wlj.2	+	34	3575	c.3418G>C	c.(3418-3420)GGG>CGG	p.G1140R	LRRC16B_uc001wlk.2_Intron	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1140										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GTCAGAGCCAGGGGAGGGGGG	0.607			NA											93	68					0	0	0.00361	0	0
TM9SF1	10548	broad.mit.edu	37	14	24679976	24679976	+	Splice_Site	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:24679976T>C	uc010tob.1	-	4	1072	c.438_splice	c.e4-1	p.M146_splice	CHMP4A_uc001wni.2_Splice_Site_p.M163_splice|CHMP4A_uc010toc.1_Splice_Site|CHMP4A_uc001wnj.2_Splice_Site_p.M163_splice	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a						autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		TCAATGTCCCTGAGAATGAGA	0.488			NA											7	122					0	0	0.004482	0	0
HECTD1	25831	broad.mit.edu	37	14	31592131	31592131	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:31592131C>T	uc001wrc.1	-	27	5593	c.5104G>A	c.(5104-5106)GAG>AAG	p.E1702K	HECTD1_uc001wra.1_5'UTR|HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.E1170K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1702					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ATAACCTCCTCGTATTCTTGG	0.388			NA											38	140					0	0	0.00623	0	0
PRPF39	55015	broad.mit.edu	37	14	45584071	45584071	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:45584071G>C	uc001wvz.3	+	14	2135	c.1965G>C	c.(1963-1965)CAG>CAC	p.Q655H	PRPF39_uc001wvy.3_Missense_Mutation_p.Q534H|PRPF39_uc010and.2_Missense_Mutation_p.Q445H|PRPF39_uc001wwa.1_3'UTR	NM_017922	NP_060392	Q86UA1	PRP39_HUMAN	PRP39 pre-mRNA processing factor 39 homolog	655					mRNA processing|RNA splicing	nucleus	binding			ovary(1)|breast(1)	2						ACAATTATCAGAATCCTTGGA	0.308			NA											4	55					0	0	0.009096	0	0
MAX	4149	broad.mit.edu	37	14	65544682	65544682	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:65544682G>A	uc001xif.1	-	4	414	c.244C>T	c.(244-246)CAG>TAG	p.Q82*	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Nonsense_Mutation_p.Q82*|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Nonsense_Mutation_p.Q73*|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Nonsense_Mutation_p.Q73*|MAX_uc001xij.1_Nonsense_Mutation_p.Q82*	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	82	Leucine-zipper.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		ATATCTTGCTGGTGTGTGTGG	0.542			NA											74	49					0	0	0.00361	0	0
RGS6	9628	broad.mit.edu	37	14	72921245	72921245	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:72921245T>A	uc001xna.3	+	4	717	c.194T>A	c.(193-195)ATT>AAT	p.I65N	RGS6_uc010ttn.1_Missense_Mutation_p.I65N|RGS6_uc001xmx.3_Missense_Mutation_p.I65N|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.I65N|RGS6_uc010ttp.1_Translation_Start_Site|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	65	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		GGTACTGACATTGTGCAGTGG	0.448	Ovarian(143;1926 2468 21071 48641)		NA											7	160					0	0	0.00308	0	0
C14orf49	161176	broad.mit.edu	37	14	95932297	95932297	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:95932297C>A	uc001yei.3	-	3	613	c.598G>T	c.(598-600)GAG>TAG	p.E200*	C14orf49_uc010avi.2_Nonsense_Mutation_p.E200*|C14orf49_uc001yej.1_Nonsense_Mutation_p.E200*	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	200	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GCATCGTACTCAGCCTTCATT	0.502			NA											16	57					3.41278e-10	3.88447e-10	0.00499	1	0
ATG2B	55102	broad.mit.edu	37	14	96752139	96752139	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:96752139C>G	uc001yfi.2	-	42	6555	c.6190G>C	c.(6190-6192)GAT>CAT	p.D2064H		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	2064										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGCCGGACATCTGGCCTAATT	0.537			NA											20	74					0	0	0.008871	0	0
BCL11B	64919	broad.mit.edu	37	14	99641922	99641922	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:99641922C>A	uc001yga.2	-	4	1518	c.1251G>T	c.(1249-1251)ACG>ACT	p.T417T	BCL11B_uc001ygb.2_Silent_p.T346T	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	417						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GCGGGGGCGGCGTGCCGCCAG	0.687			NA	T	TLX3	T-ALL								28	9					1.74197e-06	1.86776e-06	0.00632	1	0
RTL1	388015	broad.mit.edu	37	14	101348393	101348393	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:101348393G>T	uc010txj.1	-	1	2792	c.2733C>A	c.(2731-2733)TCC>TCA	p.S911S	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	911										pancreas(1)	1						CCTCGATAGGGGAGATGTTGC	0.587			NA											7	22					2.0095e-06	2.14522e-06	0.001984	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102493027	102493027	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:102493027C>T	uc001yks.2	+	44	8918	c.8754C>T	c.(8752-8754)CAC>CAT	p.H2918H		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2918	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCCTAGACCACGTGCTGAGGA	0.438			NA											36	29					0	0	0.002836	0	0
KIAA0284	283638	broad.mit.edu	37	14	105350319	105350319	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr14:105350319G>A	uc010axb.2	+	9	1427	c.1203G>A	c.(1201-1203)CAG>CAA	p.Q401Q	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Silent_p.Q331Q|KIAA0284_uc001yps.2_Silent_p.Q307Q	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	401						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		TACATAACCAGCAGGCCTTTG	0.662			NA											12	12					0	0	0.001368	0	0
OR4M2	390538	broad.mit.edu	37	15	22368735	22368735	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:22368735C>T	uc010tzu.1	+	1	160	c.160C>T	c.(160-162)CAT>TAT	p.H54Y	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTAGACCCTCATCTGACCTC	0.403			NA											17	741					0	0	0.008871	0	0
OR4M2	390538	broad.mit.edu	37	15	22368914	22368914	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:22368914C>A	uc010tzu.1	+	1	339	c.339C>A	c.(337-339)TTC>TTA	p.F113L	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CGGAGATGTTCTTGCTCACAG	0.468			NA											72	423					7.46257e-40	1.09975e-39	0.00361	1	0
NIPA1	123606	broad.mit.edu	37	15	23052651	23052651	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:23052651G>A	uc001yvc.2	-	4	447	c.422C>T	c.(421-423)CCA>CTA	p.P141L	NIPA1_uc001yvd.2_5'UTR|NIPA1_uc001yve.2_Missense_Mutation_p.P66L	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	141	Extracellular (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		CTCAGACTTTGGGGAGTGGAT	0.493			NA											71	128					0	0	0.00361	0	0
SNRPN	6638	broad.mit.edu	37	15	25222062	25222062	+	Silent	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:25222062A>T	uc001ywp.1	+	10	1196	c.306A>T	c.(304-306)GGA>GGT	p.G102G	SNRPN_uc001ywq.1_Silent_p.G102G|SNRPN_uc001ywr.1_Silent_p.G102G|SNRPN_uc001yws.1_Silent_p.G102G|SNRPN_uc001ywt.1_Silent_p.G102G|SNRPN_uc001ywv.1_Silent_p.G105G|SNRPN_uc001yww.1_Silent_p.G102G|SNRPN_uc001ywx.1_Silent_p.G102G|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	102					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GAGCTGCTGGAGGCCCTGGGG	0.527			NA							Prader-Willsyndrome				33	114					0	0	0.004289	0	0
HERC2	8924	broad.mit.edu	37	15	28473435	28473435	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:28473435C>A	uc001zbj.2	-	35	5499	c.5393G>T	c.(5392-5394)GGC>GTC	p.G1798V		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1798					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTTGTTTGCGCCGTGCTGCAG	0.617			NA											18	44					2.94398e-08	3.23442e-08	0.007413	1	0
HERC2	8924	broad.mit.edu	37	15	28493784	28493784	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:28493784G>A	uc001zbj.2	-	21	3255	c.3149C>T	c.(3148-3150)TCA>TTA	p.S1050L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1050					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAAATCCAATGAAGCAGATCT	0.388			NA											11	46					0	0	0.010729	0	0
MTMR15	22909	broad.mit.edu	37	15	31197848	31197848	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:31197848G>C	uc001zff.2	+	2	1273	c.982G>C	c.(982-984)GAT>CAT	p.D328H	MTMR15_uc001zfc.3_Missense_Mutation_p.D328H|MTMR15_uc010azw.2_Missense_Mutation_p.D328H|MTMR15_uc001zfd.3_Missense_Mutation_p.D328H|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	328					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		TAGTTCTGCAGATGATGCTTC	0.433			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					4	59					0	0	0.009096	0	0
C15orf55	256646	broad.mit.edu	37	15	34648927	34648927	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:34648927T>A	uc001zif.2	+	7	2789	c.2634T>A	c.(2632-2634)CCT>CCA	p.P878P	C15orf55_uc010ucc.1_Silent_p.P906P|C15orf55_uc010ucd.1_Silent_p.P896P	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	878						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCTCCTTGCCTGAAGCCAGTC	0.498			NA	T	BRD3|BRD4	lethal midline carcinoma								24	66					0	0	0.00278	0	0
FSIP1	161835	broad.mit.edu	37	15	40068673	40068673	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:40068673G>C	uc001zki.2	-	2	271	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	18										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		GCGTATTCTTGAATTTGAAGC	0.358			NA											7	98					0	0	0.00308	0	0
LTK	4058	broad.mit.edu	37	15	41799484	41799484	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:41799484C>A	uc001zoa.3	-	11	1528	c.1350G>T	c.(1348-1350)AAG>AAT	p.K450N	LTK_uc001zob.3_Missense_Mutation_p.K389N|LTK_uc010ucx.1_Intron|LTK_uc010bcg.2_Missense_Mutation_p.K148N	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	450	Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		ACTTCTTCTGCTTCACTGGGG	0.602			NA								TSP Lung(18;0.14)			15	32					1.5739e-10	1.79979e-10	0.004007	1	0
MAP1A	4130	broad.mit.edu	37	15	43817250	43817250	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:43817250C>A	uc001zrt.2	+	4	4046	c.3579C>A	c.(3577-3579)GAC>GAA	p.D1193E		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1193						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CTCCAGAAGACACCCAGTCAC	0.552			NA											43	81					1.62957e-23	2.16687e-23	0.00874	1	0
SERINC4	619189	broad.mit.edu	37	15	44088828	44088828	+	Silent	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:44088828A>G	uc010bds.1	-	5	789	c.321T>C	c.(319-321)TGT>TGC	p.C107C	ELL3_uc001zsx.1_5'UTR|C15orf63_uc001ztb.2_Intron|MIR1282_hsa-mir-1282|MI0006429_5'Flank|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_Intron|SERINC4_uc001zte.1_Silent_p.C107C	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	351	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		CAAAAAGCACACAAGCATACA	0.498			NA											49	112					0	0	0.00361	0	0
GALK2	2585	broad.mit.edu	37	15	49620315	49620315	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:49620315A>T	uc001zxj.1	+	10	1434	c.1336A>T	c.(1336-1338)ACC>TCC	p.T446S	GALK2_uc001zxi.1_Missense_Mutation_p.T435S|GALK2_uc010ufb.1_Missense_Mutation_p.T422S|GALK2_uc001zxk.2_RNA|GALK2_uc010ufc.1_Missense_Mutation_p.T422S	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1	446					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		TTTGTTTGCTACCAAACCTGG	0.463			NA											21	46					0	0	0.010504	0	0
ATP8B4	79895	broad.mit.edu	37	15	50154487	50154487	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:50154487T>C	uc001zxu.2	-	27	3394	c.3252A>G	c.(3250-3252)GCA>GCG	p.A1084A	ATP8B4_uc010ber.2_Silent_p.A957A|ATP8B4_uc010ufd.1_Silent_p.A894A|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Silent_p.A87A	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1084	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AAAATCTGAATGCCACCACTG	0.423			NA											16	39					0	0	0.003163	0	0
DMXL2	23312	broad.mit.edu	37	15	51772810	51772810	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:51772810G>A	uc002abf.2	-	24	6718	c.6493C>T	c.(6493-6495)CAT>TAT	p.H2165Y	DMXL2_uc002abd.2_Missense_Mutation_p.H235Y|DMXL2_uc010ufy.1_Missense_Mutation_p.H2165Y|DMXL2_uc010bfa.2_Missense_Mutation_p.H1529Y	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2165						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TGGGCCCCATGAAGGCTACAG	0.428			NA											5	143					0	0	0.000602	0	0
UNC13C	440279	broad.mit.edu	37	15	54542458	54542458	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:54542458G>T	uc002ack.2	+	6	3264	c.3264G>T	c.(3262-3264)CTG>CTT	p.L1088L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1088					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGCAGGCACTGATCTACCCTA	0.463			NA											14	67					2.32078e-09	2.59631e-09	0.003163	1	0
ADAM10	102	broad.mit.edu	37	15	58974496	58974496	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:58974496A>T	uc002afd.1	-	3	668	c.224T>A	c.(223-225)ATG>AAG	p.M75K	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Missense_Mutation_p.M75K	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	75	Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		GTCCCTCTTCATTCGTAGGTT	0.289			NA											26	50					0	0	0.012213	0	0
VPS13C	54832	broad.mit.edu	37	15	62169227	62169227	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:62169227T>A	uc002agz.2	-	75	10243	c.10169A>T	c.(10168-10170)CAG>CTG	p.Q3390L	VPS13C_uc002aha.2_Missense_Mutation_p.Q3347L|VPS13C_uc002ahb.1_Missense_Mutation_p.Q3390L|VPS13C_uc002ahc.1_Missense_Mutation_p.Q3347L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3390					protein localization					ovary(2)	2						CTTGTAGAACTGATATCGAAT	0.289			NA											47	120					0	0	0.00361	0	0
SGK269	79834	broad.mit.edu	37	15	77425939	77425939	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:77425939C>T	uc002bcm.2	-	5	3793	c.3485G>A	c.(3484-3486)AGA>AAA	p.R1162K		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1162					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TGTATTGGCTCTTATGATCAT	0.493			NA											32	162					0	0	0.008361	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:78211548T>C	uc010bky.2	-	11	983	c.219A>G	c.(217-219)CAA>CAG	p.Q73Q		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CCACCTGGGATTGGAGCTTTC	0.562			NA											4	308					0	0	0.009096	0	0
RASGRF1	5923	broad.mit.edu	37	15	79291123	79291123	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:79291123G>A	uc002beq.2	-	19	3214	c.2839C>T	c.(2839-2841)CGC>TGC	p.R947C	RASGRF1_uc002bep.2_Missense_Mutation_p.R931C|RASGRF1_uc010blm.1_Missense_Mutation_p.R856C|RASGRF1_uc002ber.3_Missense_Mutation_p.R931C|RASGRF1_uc010unh.1_Missense_Mutation_p.R342C|RASGRF1_uc002beo.2_Missense_Mutation_p.R163C	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	949					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCTGCTCTGCGGATCACAAAC	0.612			NA											21	92					0	0	0.002299	0	0
FAM154B	283726	broad.mit.edu	37	15	82574765	82574765	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:82574765G>T	uc002bgv.2	+	3	628	c.559G>T	c.(559-561)GAC>TAC	p.D187Y	FAM154B_uc010unr.1_Missense_Mutation_p.D172Y|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	187										skin(2)	2						TCACCGGTGTGACTTTCAGGG	0.443			NA											29	63					2.48779e-11	2.85819e-11	0.005443	1	0
AP3B2	8120	broad.mit.edu	37	15	83331452	83331452	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:83331452C>T	uc010uoh.1	-	22	2947	c.2770G>A	c.(2770-2772)GAA>AAA	p.E924K	AP3B2_uc010uoi.1_Missense_Mutation_p.E943K|AP3B2_uc010uoj.1_Missense_Mutation_p.E892K|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Missense_Mutation_p.E560K	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	924					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCACCAATTTCGGGAAATTCT	0.577			NA											5	14					0	0	0.000602	0	0
ACAN	176	broad.mit.edu	37	15	89381918	89381918	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:89381918G>C	uc010upo.1	+	3	469	c.95G>C	c.(94-96)AGC>ACC	p.S32T	ACAN_uc002bmx.2_Missense_Mutation_p.S32T|ACAN_uc010upp.1_Missense_Mutation_p.S32T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	32					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGAGTGTCAGCATCCCCCAA	0.612			NA											8	157					0	0	0.004482	0	0
ACAN	176	broad.mit.edu	37	15	89386626	89386626	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:89386626C>T	uc010upo.1	+	6	1172	c.798C>T	c.(796-798)TTC>TTT	p.F266F	ACAN_uc002bmx.2_Silent_p.F266F|ACAN_uc010upp.1_Silent_p.F266F|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	266					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTTCACCTTCCAGGAAGCAG	0.632			NA											18	29					0	0	0.010504	0	0
MAN2A2	4122	broad.mit.edu	37	15	91456191	91456191	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:91456191C>T	uc010bnz.2	+	17	2669	c.2554C>T	c.(2554-2556)CAC>TAC	p.H852Y	MAN2A2_uc002bqc.2_Missense_Mutation_p.H852Y|MAN2A2_uc010uql.1_Missense_Mutation_p.H514Y|MAN2A2_uc010uqm.1_Missense_Mutation_p.H431Y|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	852					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGAGCACATTCACCAGGCGGT	0.567			NA											5	98					0	0	0.001168	0	0
VPS33B	26276	broad.mit.edu	37	15	91561108	91561108	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:91561108C>T	uc002bqp.1	-	2	458	c.104G>A	c.(103-105)GGA>GAA	p.G35E	VPS33B_uc002bqq.1_5'UTR|VPS33B_uc010uqu.1_Intron	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	35					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					ATCCTTTTTTCCAGGAAGCTG	0.498			NA											5	98					0	0	0.001984	0	0
TARSL2	123283	broad.mit.edu	37	15	102242533	102242533	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr15:102242533T>C	uc002bxm.2	-	9	1185	c.1130A>G	c.(1129-1131)TAT>TGT	p.Y377C	TARSL2_uc002bxl.2_5'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	377					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGATATTCCATAGATCCTCTG	0.403			NA											38	113					0	0	0.004878	0	0
ITFG3	83986	broad.mit.edu	37	16	313761	313761	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:313761G>T	uc002cgf.2	+	10	1370	c.1175G>T	c.(1174-1176)GGC>GTC	p.G392V	ITFG3_uc002cgg.2_Missense_Mutation_p.G392V|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.G392V	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	392	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AACGGAACTGGCACCGACAGA	0.552			NA											26	72					1.2476e-16	1.53986e-16	0.00632	1	0
SSTR5	6755	broad.mit.edu	37	16	1129862	1129862	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:1129862G>A	uc002ckq.2	+	1	1082	c.994G>A	c.(994-996)GCC>ACC	p.A332T	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	332	Cytoplasmic (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GGACGCTGACGCCACGGAGCC	0.662			NA											23	32					0	0	0.002299	0	0
CLCN7	1186	broad.mit.edu	37	16	1499037	1499037	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:1499037T>A	uc002clv.2	-	19	1837	c.1727A>T	c.(1726-1728)AAC>ATC	p.N576I	CLCN7_uc010brq.1_5'Flank|CLCN7_uc002clu.2_Missense_Mutation_p.N24I|CLCN7_uc002clw.2_Missense_Mutation_p.N552I	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	576						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				GTAGGTCACGTTGCTGGTGGC	0.622			NA											12	68					0	0	0.001368	0	0
IFT140	9742	broad.mit.edu	37	16	1634398	1634398	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:1634398C>T	uc002cmb.2	-	11	1541	c.1179G>A	c.(1177-1179)CTG>CTA	p.L393L	IFT140_uc002clz.2_Silent_p.L44L	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	393										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGTTCACTGCCAGCAGGTTCT	0.557			NA											6	29					0	0	0.001168	0	0
HS3ST6	64711	broad.mit.edu	37	16	1961980	1961980	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:1961980C>G	uc002cnf.2	-	2	547	c.547G>C	c.(547-549)GGC>CGC	p.G183R		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	183											0						TCCACGGGGCCCAGGCCGTGG	0.711			NA											42	16					0	0	0.007835	0	0
CASKIN1	57524	broad.mit.edu	37	16	2239047	2239047	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:2239047C>T	uc010bsg.1	-	6	630	c.598G>A	c.(598-600)GGC>AGC	p.G200S		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	200	ANK 5.				signal transduction	cytoplasm				skin(2)	2						TCGATGTGGCCGTTTTTAGCT	0.652			NA											29	114					0	0	0.008361	0	0
KCTD5	54442	broad.mit.edu	37	16	2749879	2749879	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:2749879A>T	uc002crd.2	+	4	566	c.511A>T	c.(511-513)ATG>TTG	p.M171L		NM_018992	NP_061865	Q9NXV2	KCTD5_HUMAN	potassium channel tetramerisation domain	171					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity				0						GCTCACGCAGATGGTGTCCAC	0.622	Ovarian(56;981 1456 4301 50892)		NA											35	104					0	0	0.004289	0	0
SRRM2	23524	broad.mit.edu	37	16	2813036	2813036	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:2813036C>T	uc002crk.2	+	11	3056	c.2507C>T	c.(2506-2508)TCC>TTC	p.S836F	SRRM2_uc002crj.1_Missense_Mutation_p.S740F|SRRM2_uc002crl.1_Missense_Mutation_p.S836F|SRRM2_uc010bsu.1_Missense_Mutation_p.S740F	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	836	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAAAGTCATTCCAGTTCATCT	0.483			NA											71	334					0	0	0.00361	0	0
CREBBP	1387	broad.mit.edu	37	16	3790432	3790432	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:3790432C>G	uc002cvv.2	-	24	4305	c.4101G>C	c.(4099-4101)AAG>AAC	p.K1367N	CREBBP_uc002cvw.2_Missense_Mutation_p.K1329N	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1367	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCTCCACCGTCTTGTCTGAGC	0.592			NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybsyndrome				15	92					0	0	0.006122	0	0
GLYR1	84656	broad.mit.edu	37	16	4862237	4862237	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:4862237T>A	uc002cxx.3	-	13	1169	c.1132A>T	c.(1132-1134)AGG>TGG	p.R378W	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.R292W|GLYR1_uc002cya.2_Missense_Mutation_p.R372W|GLYR1_uc010uxv.1_Missense_Mutation_p.R297W	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	378					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						CGCCCCCCCCTGGACACAATC	0.582			NA											11	35					0	0	0.001368	0	0
NUBP1	4682	broad.mit.edu	37	16	10855248	10855248	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:10855248G>C	uc002daa.1	+	8	657	c.634G>C	c.(634-636)GAA>CAA	p.E212Q	FAM18A_uc010uyr.1_RNA|FAM18A_uc010uys.1_RNA|FAM18A_uc010uyt.1_RNA|FAM18A_uc010bun.2_RNA|FAM18A_uc010uyu.1_RNA|FAM18A_uc002dad.3_RNA|NUBP1_uc010bum.1_Missense_Mutation_p.E77Q|NUBP1_uc002dab.1_Missense_Mutation_p.E201Q	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	212					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						TGTCCGGAAAGAAATCAACTT	0.542			NA											6	94					0	0	0.001168	0	0
TNP2	7142	broad.mit.edu	37	16	11362792	11362792	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:11362792C>G	uc002das.2	-	1	369	c.328G>C	c.(328-330)GAA>CAA	p.E110Q	C16orf75_uc002daq.1_Intron	NM_005425	NP_005416	Q05952	STP2_HUMAN	transition protein 2 (during histone to	110					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding				0						AGCTTGCCTTCCAAGTTCTTT	0.537			NA											3	110					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	16	15023187	15023188	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:15023187_15023188GG>TT	uc010uzk.1	+	6	1032_1033	c.756_757GG>TT	c.(754-759)ATGGTG>ATTTTG	p.252_253MV>IL	NPIP_uc002dcx.3_RNA					SubName: Full=cDNA FLJ57488, highly similar to Polycystin-1;												NA						CATCGCGGATGGTGGCGTCCCA	0.668			NA											10	7					0	0	0.004672	0	0
MYH11	4629	broad.mit.edu	37	16	15844070	15844070	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:15844070C>A	uc002ddy.2	-	16	2090	c.1983G>T	c.(1981-1983)CTG>CTT	p.L661L	MYH11_uc002ddv.2_Silent_p.L668L|MYH11_uc002ddw.2_Silent_p.L661L|MYH11_uc002ddx.2_Silent_p.L668L|MYH11_uc010bvg.2_Silent_p.L493L|MYH11_uc002dea.1_Silent_p.L367L	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	661	Myosin head-like.|Actin-binding (By similarity).				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TCAGCTTGCCCAGCTGCTCCT	0.632			NA	T	CBFB	AML								60	68					9.40535e-28	1.29638e-27	0.00361	1	0
ACSM2A	123876	broad.mit.edu	37	16	20480947	20480947	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:20480947G>C	uc010bwe.2	+	5	741	c.502G>C	c.(502-504)GAC>CAC	p.D168H	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.D89H|ACSM2A_uc002dhf.3_Missense_Mutation_p.D168H|ACSM2A_uc002dhg.3_Missense_Mutation_p.D168H|ACSM2A_uc010vay.1_Missense_Mutation_p.D89H	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	168					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCAAGAAGTGGACACAGTGGC	0.453			NA											42	198					0	0	0.00361	0	0
ACSM2A	123876	broad.mit.edu	37	16	20487072	20487072	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:20487072G>A	uc010bwe.2	+	9	1314	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	ACSM2A_uc010vax.1_Missense_Mutation_p.E280K|ACSM2A_uc002dhf.3_Missense_Mutation_p.E359K|ACSM2A_uc002dhg.3_Missense_Mutation_p.E359K|ACSM2A_uc010vay.1_Missense_Mutation_p.E280K|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	359	ATP.				fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GGACATCCGAGAATCCTATGG	0.488			NA											51	317					0	0	0.00361	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492161	20492161	+	Missense_Mutation	SNP	C	C	G	rs75603553	byFrequency	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:20492161C>G	uc010bwe.2	+	13	1666	c.1427C>G	c.(1426-1428)TCG>TGG	p.S476W	ACSM2A_uc010vax.1_Missense_Mutation_p.S397W|ACSM2A_uc002dhf.3_Missense_Mutation_p.S476W|ACSM2A_uc002dhg.3_Missense_Mutation_p.S476W|ACSM2A_uc010vay.1_Missense_Mutation_p.S397W|ACSM2A_uc002dhh.3_Missense_Mutation_p.S106W	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	476					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						ATTGGACCCTCGGAGGTAGAG	0.567			NA											20	116					0	0	0.012319	0	0
ACSM3	6296	broad.mit.edu	37	16	20793094	20793094	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:20793094A>G	uc002dhr.2	+	7	1191	c.1004A>G	c.(1003-1005)CAG>CGG	p.Q335R	ACSM3_uc002dhq.2_Missense_Mutation_p.Q335R|ACSM3_uc010vba.1_Missense_Mutation_p.Q364R|ERI2_uc002dhs.2_Intron	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	335					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						ATGCTTGTACAGAATGATATA	0.393			NA											36	55					0	0	0.004878	0	0
METTL9	51108	broad.mit.edu	37	16	21611105	21611105	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:21611105G>A	uc002dje.2	+	1	250	c.51G>A	c.(49-51)CTG>CTA	p.L17L	uc002diq.3_Intron|METTL9_uc002djf.2_Silent_p.L17L	NM_016025	NP_057109	Q9H1A3	METL9_HUMAN	methyltransferase like 9 isoform 1	17										ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)		CCGTGTGGCTGGCGCGGAGGA	0.597			NA											5	22					0	0	0.000602	0	0
VWA3A	146177	broad.mit.edu	37	16	22163858	22163858	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:22163858T>A	uc010vbq.1	+	31	3404	c.3308T>A	c.(3307-3309)CTG>CAG	p.L1103Q	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Missense_Mutation_p.L181Q|VWA3A_uc010bxe.1_Missense_Mutation_p.L205Q	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1103	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CTGAGAAAGCTGGCTTCCTTC	0.562			NA											7	26					0	0	0.004482	0	0
ERN2	10595	broad.mit.edu	37	16	23713772	23713772	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:23713772G>T	uc002dma.3	-	10	1333	c.1164C>A	c.(1162-1164)CCC>CCA	p.P388P	ERN2_uc010bxp.2_Silent_p.P388P|ERN2_uc010bxq.1_Silent_p.P196P	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	340	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CAGCAGTGCTGGGTGAGCCCT	0.577			NA											142	154					1.89244e-60	2.91603e-60	0.00361	1	0
TNRC6A	27327	broad.mit.edu	37	16	24804935	24804935	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:24804935C>G	uc002dmm.2	+	7	3431	c.3317C>G	c.(3316-3318)TCC>TGC	p.S1106C	TNRC6A_uc010bxs.2_Missense_Mutation_p.S853C|TNRC6A_uc010vcc.1_Missense_Mutation_p.S853C|TNRC6A_uc002dmn.2_Missense_Mutation_p.S853C|TNRC6A_uc002dmo.2_Intron	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1106	Sufficient for interaction with EIF2C1 and EIF2C4.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ACGTGGGGCTCCAGCTCTGTT	0.502			NA											22	184					0	0	0.012319	0	0
GTF3C1	2975	broad.mit.edu	37	16	27472818	27472818	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:27472818G>A	uc002dov.1	-	37	6223	c.6183C>T	c.(6181-6183)TTC>TTT	p.F2061F	GTF3C1_uc002dou.2_Silent_p.F2036F	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2061						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CGGGTGTAGAGAAGAGCGAGA	0.627			NA											83	111					0	0	0.00361	0	0
ITGAM	3684	broad.mit.edu	37	16	31336590	31336590	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:31336590C>A	uc002ebq.2	+	20	2468	c.2370C>A	c.(2368-2370)GAC>GAA	p.D790E	ITGAM_uc002ebr.2_Missense_Mutation_p.D791E|ITGAM_uc010can.2_Missense_Mutation_p.D196E|ITGAM_uc002ebs.1_Missense_Mutation_p.D196E|ITGAM_uc010vfj.1_RNA	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	790	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						ACAGCCTGGACTGCCTCGTGG	0.597			NA											10	48					1.58986e-06	1.70841e-06	0.008291	1	0
SHCBP1	79801	broad.mit.edu	37	16	46633756	46633756	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:46633756T>A	uc002eec.3	-	9	1372	c.1332A>T	c.(1330-1332)GTA>GTT	p.V444V		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	444	PbH1 1.									ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				AGATTCCCTCTACAGCATCAT	0.358			NA											28	33					0	0	0.010818	0	0
MMP2	4313	broad.mit.edu	37	16	55516994	55516994	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:55516994C>T	uc002ehz.3	+	2	638	c.327C>T	c.(325-327)AAC>AAT	p.N109N	MMP2_uc010vhd.1_Silent_p.N33N|MMP2_uc010ccc.2_Silent_p.N59N	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	109					angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	ATGTGGCCAACTACAACTTCT	0.582			NA											25	121					0	0	0.004656	0	0
MMP2	4313	broad.mit.edu	37	16	55519238	55519238	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:55519238G>T	uc002ehz.3	+	4	868	c.557G>T	c.(556-558)GGT>GTT	p.G186V	MMP2_uc010vhd.1_Missense_Mutation_p.G110V|MMP2_uc010ccc.2_Missense_Mutation_p.G136V	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	186	Collagenase-like 1.	Calcium 3; via carbonyl oxygen (By similarity).			angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CCCTTTGACGGTAAGGACGGA	0.562			NA											79	93					2.84431e-33	4.05149e-33	0.00361	1	0
MT1H	4496	broad.mit.edu	37	16	56704873	56704873	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:56704873C>G	uc002ejw.2	+	3	229	c.158C>G	c.(157-159)GCG>GGG	p.A53G	MT1G_uc002eju.1_5'Flank|MT1G_uc002ejv.1_5'Flank	NM_005951	NP_005942	P80294	MT1H_HUMAN	metallothionein 1H	53	Alpha.						metal ion binding|protein binding				0						TGCAAAGGGGCGTCAGAGAAG	0.532			NA											12	126					0	0	0.00245	0	0
ZNF319	57567	broad.mit.edu	37	16	58030659	58030659	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:58030659T>G	uc002emx.1	-	2	2134	c.1511A>C	c.(1510-1512)CAC>CCC	p.H504P		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	504	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACCCGCCGGTGCCGCTGCAG	0.637			NA											15	13					0	0	0.003163	0	0
CMTM1	113540	broad.mit.edu	37	16	66612833	66612833	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:66612833G>A	uc002epi.3	+	4	562	c.439G>A	c.(439-441)GAA>AAA	p.E147K	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_RNA|CMTM1_uc002epe.3_RNA|CMTM1_uc002epf.3_RNA|CMTM1_uc002epg.3_RNA|CMTM1_uc002eph.3_3'UTR|CMTM1_uc002epl.3_Missense_Mutation_p.E100K|CMTM1_uc002epj.3_3'UTR|CMTM1_uc002epk.3_Missense_Mutation_p.E94K|CMTM1_uc002epa.3_3'UTR|CMTM1_uc002epn.3_3'UTR|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Missense_Mutation_p.E264K|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA|CMTM2_uc002ept.2_5'Flank|CMTM2_uc010cdu.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	147					chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		AGTCGAAGTTGAAAGGAAGCT	0.607			NA											35	168					0	0	0.004289	0	0
FUK	197258	broad.mit.edu	37	16	70497154	70497154	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:70497154A>T	uc002eyy.2	+	2	119	c.61A>T	c.(61-63)AGT>TGT	p.S21C	FUK_uc010vmb.1_Missense_Mutation_p.S21C|FUK_uc010cft.2_Missense_Mutation_p.S21C|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	21						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GTACAAGGACAGTGTCCAGGT	0.562			NA											46	33					0	0	0.00361	0	0
HYDIN	54768	broad.mit.edu	37	16	70908800	70908800	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:70908800T>A	uc002ezr.2	-	63	10705	c.10577A>T	c.(10576-10578)GAG>GTG	p.E3526V		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3527										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GACTCCTAGCTCATCCTGCAG	0.522			NA											21	11					0	0	0.00632	0	0
ZFHX3	463	broad.mit.edu	37	16	72830446	72830446	+	Silent	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:72830446T>G	uc002fck.2	-	9	6808	c.6135A>C	c.(6133-6135)CCA>CCC	p.P2045P	ZFHX3_uc002fcl.2_Silent_p.P1131P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2045	Poly-Pro.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GTGGAGGGGGTGGAGGGGGAG	0.632			NA											11	83					0	0	0.002299	0	0
ZNRF1	84937	broad.mit.edu	37	16	75127513	75127513	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:75127513G>C	uc002fdk.2	+	2	1123	c.468G>C	c.(466-468)GAG>GAC	p.E156D	ZNRF1_uc010vmz.1_Missense_Mutation_p.E156D|ZNRF1_uc002fdl.1_Missense_Mutation_p.E156D|ZNRF1_uc010cgr.1_Missense_Mutation_p.E156D	NM_032268	NP_115644	Q8ND25	ZNRF1_HUMAN	zinc and ring finger protein 1	156						cell junction|endosome|lysosome|synaptic vesicle membrane	ligase activity|protein binding|zinc ion binding				0						CTTCTGACGAGATGGAAATGC	0.502			NA											43	31					0	0	0.013114	0	0
BCMO1	53630	broad.mit.edu	37	16	81320966	81320966	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:81320966G>A	uc002fgn.1	+	10	1587	c.1369G>A	c.(1369-1371)GAA>AAA	p.E457K	BCMO1_uc010vnp.1_Missense_Mutation_p.E388K	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	457					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						CTGGCCAGCGGAACCCCTGTT	0.493			NA											4	106					0	0	0.001984	0	0
MPHOSPH6	10200	broad.mit.edu	37	16	82182995	82182995	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:82182995T>A	uc002fgw.2	-	4	318	c.269A>T	c.(268-270)CAG>CTG	p.Q90L		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	90					M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						AGCATTCATCTGAAGCATCAA	0.433			NA											71	63					0	0	0.00361	0	0
COX4NB	10328	broad.mit.edu	37	16	85814046	85814046	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:85814046C>A	uc002fjd.2	-	4	659	c.412G>T	c.(412-414)GCG>TCG	p.A138S	COX4NB_uc010vol.1_Intron	NM_006067	NP_006058	O43402	CX4NB_HUMAN	COX4 neighbor isoform 1	138						mitochondrion|nucleus					0						ATCGTAGGCGCTACGCAGTCC	0.602			NA											14	41					4.14922e-12	4.82926e-12	0.004007	1	0
BANP	54971	broad.mit.edu	37	16	88039714	88039714	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:88039714G>T	uc002fkr.2	+	6	695	c.471G>T	c.(469-471)CGG>CGT	p.R157R	BANP_uc002fkp.2_Silent_p.R127R|BANP_uc002fkq.2_Silent_p.R127R|BANP_uc010vow.1_Silent_p.R165R|BANP_uc002fks.3_Silent_p.R126R|BANP_uc002fko.1_Silent_p.R63R|BANP_uc010vov.1_Silent_p.R132R	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	158	Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		CTGGGCGTCGGCAGAACACCA	0.612			NA											80	63					5.02048e-33	7.13054e-33	0.00361	1	0
CDH15	1013	broad.mit.edu	37	16	89259965	89259965	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:89259965G>C	uc002fmt.2	+	12	2020	c.1943G>C	c.(1942-1944)CGA>CCA	p.R648P		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	648	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GACGACCTTCGAGACAATGTC	0.672			NA											6	38					0	0	0.001168	0	0
OR1D2	4991	broad.mit.edu	37	17	2995893	2995893	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:2995893G>T	uc010vrb.1	-	1	398	c.398C>A	c.(397-399)ACC>AAC	p.T133N		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	133	Cytoplasmic (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CATGGCTGTGGTGTAGTGGAG	0.552			NA											88	42					8.6838e-40	1.27588e-39	0.00361	1	0
OR1E2	8388	broad.mit.edu	37	17	3336698	3336698	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:3336698G>T	uc010vre.1	-	1	438	c.438C>A	c.(436-438)AGC>AGA	p.S146R		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	146	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						AGAGCATGGGGCTCATGATGG	0.567			NA											50	26					3.39706e-21	4.39777e-21	0.00361	1	0
ITGAE	3682	broad.mit.edu	37	17	3660400	3660400	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:3660400G>T	uc002fwo.3	-	10	1148	c.1049C>A	c.(1048-1050)ACT>AAT	p.T350N		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	350	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TTCCCTCGCAGTCCTAGCACT	0.473	NSCLC(182;635 2928 8995 38788)		NA											190	109					6.82201e-104	1.08006e-103	0.00361	1	0
DLG4	1742	broad.mit.edu	37	17	7107548	7107548	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:7107548G>A	uc002get.3	-	5	1450	c.249C>T	c.(247-249)GTC>GTT	p.V83V	DLG4_uc010vtm.1_5'Flank|DLG4_uc010vtn.1_5'UTR|DLG4_uc010cly.2_Silent_p.V40V|DLG4_uc010vto.1_Silent_p.V83V|DLG4_uc002geu.2_Silent_p.V40V	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	40					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						TATCTGTGTTGACAATCACTG	0.527			NA											15	25					0	0	0.004007	0	0
TP53	7157	broad.mit.edu	37	17	7578461	7578461	+	Missense_Mutation	SNP	C	C	A	rs121912654		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:7578461C>A	uc002gim.2	-	5	663	c.469G>T	c.(469-471)GTC>TTC	p.V157F	TP53_uc002gig.1_Missense_Mutation_p.V157F|TP53_uc002gih.2_Missense_Mutation_p.V157F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25F|TP53_uc010cng.1_Missense_Mutation_p.V25F|TP53_uc002gii.1_Missense_Mutation_p.V25F|TP53_uc010cnh.1_Missense_Mutation_p.V157F|TP53_uc010cni.1_Missense_Mutation_p.V157F|TP53_uc002gij.2_Missense_Mutation_p.V157F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64F|TP53_uc002gio.2_Missense_Mutation_p.V25F|TP53_uc010vug.1_Missense_Mutation_p.V118F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			57	32					4.88482e-21	6.30715e-21	0.00361	1	0
PER1	5187	broad.mit.edu	37	17	8044469	8044469	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:8044469G>C	uc002gkd.2	-	23	4028	c.3790C>G	c.(3790-3792)CAG>GAG	p.Q1264E	PER1_uc010cns.2_Missense_Mutation_p.Q138E|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1264	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GCCAAGTCCTGAGAGCTTGAA	0.622			NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					72	265					0	0	0.00361	0	0
MYH13	8735	broad.mit.edu	37	17	10265445	10265445	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:10265445G>A	uc002gmk.1	-	5	585	c.495C>T	c.(493-495)TTC>TTT	p.F165F		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	165	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CAGTCAGCATGAACTGATAGG	0.483			NA											61	213					0	0	0.00361	0	0
MYH4	4622	broad.mit.edu	37	17	10351986	10351986	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:10351986C>A	uc002gmn.2	-	32	4591	c.4480G>T	c.(4480-4482)GAA>TAA	p.E1494*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1494	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCCAGGGATTCCTCGTAGGCA	0.438			NA											66	45					1.34159e-35	1.93918e-35	0.00361	1	0
MYH4	4622	broad.mit.edu	37	17	10360956	10360956	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:10360956G>T	uc002gmn.2	-	16	1789	c.1678C>A	c.(1678-1680)CTT>ATT	p.L560I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	560	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GATTTTCCAAGATGTTGTTCA	0.498			NA											15	168					1.05317e-09	1.18497e-09	0.00245	1	0
MYH4	4622	broad.mit.edu	37	17	10367813	10367813	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:10367813C>T	uc002gmn.2	-	7	735	c.624G>A	c.(622-624)GAG>GAA	p.E208E	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	208	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGGCAGGTTCCTCTTTTTTCT	0.353			NA											41	24					0	0	0.00623	0	0
MYH1	4619	broad.mit.edu	37	17	10397893	10397893	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:10397893G>C	uc002gmo.2	-	38	5658	c.5564C>G	c.(5563-5565)ACT>AGT	p.T1855S	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1855	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TACTTGGTAAGTGAGTTCCTT	0.378			NA											68	46					0	0	0.00361	0	0
DNAH9	1770	broad.mit.edu	37	17	11593679	11593679	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:11593679G>C	uc002gne.2	+	20	4608	c.4540G>C	c.(4540-4542)GAA>CAA	p.E1514Q	DNAH9_uc010coo.2_Missense_Mutation_p.E808Q	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1514	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TATCTGGTTTGAAGTGCAGCG	0.493			NA											3	107					0	0	0.004672	0	0
TBC1D26	353149	broad.mit.edu	37	17	15641379	15641379	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:15641379G>T	uc010cov.2	+	6	517	c.267G>T	c.(265-267)AGG>AGT	p.R89S	TBC1D26_uc010cou.1_Missense_Mutation_p.R89S|TBC1D26_uc002gpb.3_RNA	NM_178571	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	89						intracellular	Rab GTPase activator activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		CAAAATATAGGAGCACCAAGA	0.527			NA											7	144					0.000442599	0.000458023	0.006214	1	0
COPS3	8533	broad.mit.edu	37	17	17174123	17174123	+	Splice_Site	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:17174123T>C	uc002grd.2	-	4	390	c.299_splice	c.e4-1	p.F100_splice	COPS3_uc010vwv.1_Splice_Site_p.F80_splice|COPS3_uc010vww.1_Splice_Site	NM_003653	NP_003644	Q9UNS2	CSN3_HUMAN	COP9 constitutive photomorphogenic homolog						cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			skin(1)	1						GCCCAGCAACTAGATACAATA	0.294			NA											3	8					0	0	0.004672	0	0
ULK2	9706	broad.mit.edu	37	17	19705183	19705183	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:19705183C>A	uc002gwm.3	-	16	1857	c.1348G>T	c.(1348-1350)GGA>TGA	p.G450*	ULK2_uc002gwn.2_Nonsense_Mutation_p.G450*	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	450					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GAGCATGATCCCGGCCGGAGG	0.502			NA											85	328					9.24773e-40	1.3567e-39	0.00361	1	0
EFCAB5	374786	broad.mit.edu	37	17	28405430	28405430	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:28405430C>A	uc002het.2	+	15	3127	c.2935C>A	c.(2935-2937)CGG>AGG	p.R979R	EFCAB5_uc010cse.2_Silent_p.R734R|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	979							calcium ion binding			ovary(1)|skin(1)	2						TTCTGCCAGGCGGAAATGGCT	0.493			NA											56	114					1.11015e-26	1.51525e-26	0.00361	1	0
TMIGD1	388364	broad.mit.edu	37	17	28651841	28651841	+	Silent	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:28651841A>T	uc002hfa.1	-	4	706	c.633T>A	c.(631-633)ATT>ATA	p.I211I	TMIGD1_uc010csh.1_Silent_p.I211I	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	211	Extracellular (Potential).					integral to membrane					0						TACCTTTAACAATCAGGTGAA	0.274			NA											32	92					0	0	0.009535	0	0
TMEM98	26022	broad.mit.edu	37	17	31263396	31263396	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:31263396C>G	uc002hhq.2	+	6	802	c.344C>G	c.(343-345)TCT>TGT	p.S115C	TMEM98_uc002hhr.2_Missense_Mutation_p.S115C	NM_015544	NP_056359	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	115						endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			ACAATGGGCTCTGGGGCCAAG	0.572			NA											6	182					0	0	0.00308	0	0
UNC45B	146862	broad.mit.edu	37	17	33475423	33475423	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:33475423G>T	uc002hja.2	+	2	238	c.141G>T	c.(139-141)CGG>CGT	p.R47R	UNC45B_uc002hjb.2_Silent_p.R47R|UNC45B_uc002hjc.2_Silent_p.R47R|UNC45B_uc010cto.2_Silent_p.R47R	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	47	TPR 2.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				CGCTTTATCGGAACCGGGCAG	0.637			NA											23	56					5.45024e-15	6.56978e-15	0.00333	1	0
UNC45B	146862	broad.mit.edu	37	17	33501353	33501353	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:33501353C>A	uc002hja.2	+	14	2026	c.1929C>A	c.(1927-1929)GCC>GCA	p.A643A	UNC45B_uc002hjb.2_Silent_p.A641A|UNC45B_uc002hjc.2_Silent_p.A641A|UNC45B_uc010cto.2_Silent_p.A562A	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	643					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				CAGATAGTGCCATCCTCACTG	0.602			NA											48	99					1.02687e-29	1.42742e-29	0.013114	1	0
ACACA	31	broad.mit.edu	37	17	35609868	35609868	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:35609868G>A	uc002hnm.2	-	15	2001	c.1810C>T	c.(1810-1812)CAG>TAG	p.Q604*	ACACA_uc002hnk.2_Nonsense_Mutation_p.Q526*|ACACA_uc002hnl.2_Nonsense_Mutation_p.Q546*|ACACA_uc002hnn.2_Nonsense_Mutation_p.Q604*|ACACA_uc002hno.2_Nonsense_Mutation_p.Q641*|ACACA_uc010cuz.2_Nonsense_Mutation_p.Q604*	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	604	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTGTTCATCTGAAAGCTTTCA	0.423	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											10	201					0	0	0.006214	0	0
MLLT6	4302	broad.mit.edu	37	17	36874193	36874193	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:36874193G>A	uc002hqi.3	+	12	1942	c.1929G>A	c.(1927-1929)GAG>GAA	p.E643E	MLLT6_uc002hqj.2_Silent_p.E78E|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	643					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					CCCAAGCTGAGAGCAGCCACA	0.537			NA	T	MLL	AL								68	122					0	0	0.00361	0	0
THRA	7067	broad.mit.edu	37	17	38233829	38233829	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:38233829C>T	uc002htw.2	+	4	673	c.190C>T	c.(190-192)CAC>TAC	p.H64Y	THRA_uc010cwp.1_Missense_Mutation_p.H64Y|THRA_uc002htv.2_Missense_Mutation_p.H64Y|THRA_uc002htx.2_Missense_Mutation_p.H64Y	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	64	Nuclear receptor.|NR C4-type.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	AACTGGTTATCACTACCGCTG	0.542			NA											72	154					0	0	0.00361	0	0
KRT9	3857	broad.mit.edu	37	17	39723617	39723617	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:39723617C>T	uc002hxe.3	-	7	1846	c.1780G>A	c.(1780-1782)GGT>AGT	p.G594S	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	594	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				ccactttcacctccaaaacca	0.05			NA											6	31					0	0	0.004482	0	0
PLEKHH3	79990	broad.mit.edu	37	17	40820147	40820147	+	Nonstop_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:40820147A>T	uc002iau.2	-	13	2847	c.2380T>A	c.(2380-2382)TGA>AGA	p.*794R	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Nonstop_Mutation_p.*155R|PLEKHH3_uc002iaw.2_3'UTR	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	794					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TGGCAGGCTCAGTCCTGCAGC	0.652			NA											8	20					0	0	0.00308	0	0
RUNDC3A	10900	broad.mit.edu	37	17	42390611	42390611	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:42390611C>A	uc002igl.3	+	3	637	c.363C>A	c.(361-363)GCC>GCA	p.A121A	RUNDC3A_uc002igi.2_Silent_p.A121A|RUNDC3A_uc002igj.2_Silent_p.A116A|RUNDC3A_uc002igk.2_Silent_p.A117A	NM_001144825	NP_001138297	Q59EK9	RUN3A_HUMAN	RUN domain containing 3A isoform 1	121	Interaction with RAP2A (By similarity).|RUN.				small GTPase mediated signal transduction		small GTPase regulator activity				0		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TCAGCACAGCCCGGGCCAAGG	0.602	Pancreas(82;1061 1416 11136 20771 23901)		NA											23	58					7.92952e-12	9.19637e-12	0.003954	1	0
HOXB8	3218	broad.mit.edu	37	17	46690639	46690639	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:46690639C>A	uc002inw.2	-	2	892	c.657G>T	c.(655-657)GAG>GAT	p.E219D	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	219						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTTCTCCAGCTCCTCCTGCT	0.552			NA											90	126					9.54843e-35	1.3761e-34	0.00361	1	0
ANKRD40	91369	broad.mit.edu	37	17	48777142	48777142	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:48777142G>C	uc002iso.2	-	3	651	c.396C>G	c.(394-396)ATC>ATG	p.I132M		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	132											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGGGTGTATAGATAAAAGGGA	0.507			NA											8	110					0	0	0.004482	0	0
HLF	3131	broad.mit.edu	37	17	53398080	53398080	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:53398080G>T	uc002iug.1	+	4	1253	c.728G>T	c.(727-729)CGC>CTC	p.R243L	HLF_uc010dce.1_Missense_Mutation_p.R158L|HLF_uc002iuh.2_Missense_Mutation_p.R158L|HLF_uc010wni.1_Missense_Mutation_p.R190L	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	243	Basic motif.				multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AAGCGCTCCCGCGACGCCCGG	0.547			NA	T	TCF3	ALL								10	65					1.58986e-06	1.70841e-06	0.008291	1	0
ANKFN1	162282	broad.mit.edu	37	17	54543802	54543802	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:54543802G>T	uc002iun.1	+	14	1687	c.1652G>T	c.(1651-1653)AGG>ATG	p.R551M		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	551										large_intestine(1)|ovary(1)	2						GTCACCATCAGGGAGGTGGAG	0.413			NA											49	62					1.23713e-20	1.59315e-20	0.00361	1	0
HELZ	9931	broad.mit.edu	37	17	65163772	65163772	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:65163772C>T	uc010wqk.1	-	14	1758	c.1571G>A	c.(1570-1572)GGA>GAA	p.G524E	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.G524E	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CACCAGTCGTCCAGCCAAAGT	0.418			NA											7	105					0	0	0.001984	0	0
ABCA10	10349	broad.mit.edu	37	17	67170883	67170883	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:67170883G>A	uc010dfa.1	-	25	3792	c.2913C>T	c.(2911-2913)CTC>CTT	p.L971L	ABCA10_uc010wqs.1_Intron|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	971					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CTGAAGGCCAGAGGCCTGAAA	0.368			NA											7	196					0	0	0.001984	0	0
LLGL2	3993	broad.mit.edu	37	17	73559175	73559175	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:73559175G>A	uc002joh.2	+	7	763	c.609G>A	c.(607-609)CAG>CAA	p.Q203Q	LLGL2_uc002jog.1_Silent_p.Q203Q|LLGL2_uc010dgf.1_Silent_p.Q203Q|LLGL2_uc002joi.2_Silent_p.Q203Q|LLGL2_uc010dgg.1_Silent_p.Q203Q|LLGL2_uc002joj.2_Silent_p.Q192Q|LLGL2_uc010wsd.1_5'Flank|uc002jok.2_5'Flank	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	203	WD 4.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ACCCCAACCAGATCCTGATCG	0.657			NA											14	63					0	0	0.001855	0	0
UNC13D	201294	broad.mit.edu	37	17	73831096	73831096	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:73831096G>C	uc002jpp.2	-	21	2277	c.1897C>G	c.(1897-1899)CTA>GTA	p.L633V	UNC13D_uc010wsk.1_Missense_Mutation_p.L633V|UNC13D_uc002jpq.1_Missense_Mutation_p.L283V	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	633	MHD1.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGGTGGATAGATCCACCGCT	0.592			NA							Familial_Hemophagocytic_Lymphohistiocytosis				17	112					0	0	0.004007	0	0
AZI1	22994	broad.mit.edu	37	17	79166565	79166565	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:79166565C>T	uc002jzp.1	-	19	2609	c.2409G>A	c.(2407-2409)GAG>GAA	p.E803E	AZI1_uc002jzm.1_Silent_p.E230E|AZI1_uc002jzn.1_Silent_p.E800E|AZI1_uc002jzo.1_Intron|AZI1_uc010wum.1_Intron|AZI1_uc002jzq.2_Intron	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	803					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCCGCTCCCTCTCCTCAGCCA	0.547			NA											4	38					0	0	0.000602	0	0
AZI1	22994	broad.mit.edu	37	17	79166570	79166570	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:79166570C>G	uc002jzp.1	-	19	2604	c.2404G>C	c.(2404-2406)GAG>CAG	p.E802Q	AZI1_uc002jzm.1_Missense_Mutation_p.E229Q|AZI1_uc002jzn.1_Missense_Mutation_p.E799Q|AZI1_uc002jzo.1_Intron|AZI1_uc010wum.1_Intron|AZI1_uc002jzq.2_Intron	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	802					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TCCCTCTCCTCAGCCACCTCA	0.547			NA											4	38					0	0	0.000602	0	0
CCDC57	284001	broad.mit.edu	37	17	80137053	80137053	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:80137053C>T	uc002kdz.1	-	10	1579	c.1224G>A	c.(1222-1224)CAG>CAA	p.Q408Q	CCDC57_uc002kdx.1_Silent_p.Q408Q|CCDC57_uc010dik.1_Intron	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	408	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CCAGGGACAGCTGTTGCTTGT	0.587			NA											13	58					0	0	0.001368	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891789	5891789	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:5891789C>A	uc002kmx.1	-	1	315	c.274G>T	c.(274-276)GCG>TCG	p.A92S		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	92						integral to membrane					0						CTGCTGCCCGCAGGCGGCAGC	0.672			NA											59	31					2.69953e-25	3.63899e-25	0.00361	1	0
CEP192	55125	broad.mit.edu	37	18	13030463	13030463	+	Splice_Site	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:13030463G>C	uc010xac.1	+	11	1471	c.1391_splice	c.e11-1	p.K464_splice	CEP192_uc010dlf.1_Splice_Site|CEP192_uc010xad.1_Splice_Site_p.K59_splice|CEP192_uc002kru.2_Splice_Site|CEP192_uc002krs.1_Intron	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa											ovary(4)|pancreas(1)	5						TTATTTTTTAGAAACAGATCT	0.308			NA											6	13					0	0	0.001168	0	0
ANKRD29	147463	broad.mit.edu	37	18	21192080	21192080	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:21192080C>A	uc002kun.2	-	9	955	c.798G>T	c.(796-798)GGG>GGT	p.G266G	ANKRD29_uc002kuo.2_Intron	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	266	ANK 8.									ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATGGGTCTGCCCCTGCTTCTA	0.488			NA											61	70					5.82218e-30	8.10474e-30	0.00361	1	0
ZNF521	25925	broad.mit.edu	37	18	22804919	22804919	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:22804919C>G	uc002kvk.2	-	4	3210	c.2963G>C	c.(2962-2964)GGA>GCA	p.G988A	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G988A|ZNF521_uc002kvl.2_Missense_Mutation_p.G768A	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	988					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CCGGCAGTTTCCAGTATCAAG	0.473			NA	T	PAX5	ALL								59	113					0	0	0.00361	0	0
DSG4	147409	broad.mit.edu	37	18	28991203	28991204	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:28991203_28991204CC>AG	uc002kwq.2	+	15	2282_2283	c.2147_2148CC>AG	c.(2146-2148)ACC>AAG	p.T716K	DSG4_uc002kwr.2_Missense_Mutation_p.T735K	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	716	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAAATCTACACCAACACCTATG	0.554			NA											62	65					0	0	0.004672	0	0
ASXL3	80816	broad.mit.edu	37	18	31324568	31324568	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:31324568C>G	uc010dmg.1	+	12	4811	c.4756C>G	c.(4756-4758)CCA>GCA	p.P1586A	ASXL3_uc002kxq.2_Missense_Mutation_p.P1293A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1586					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GGCACGTGGCCCAGCTCCTTT	0.498			NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	5					0	0	0.004656	0	0
DTNA	1837	broad.mit.edu	37	18	32391950	32391950	+	Missense_Mutation	SNP	G	G	T	rs147115867	by1000genomes	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:32391950G>T	uc010dmn.1	+	5	477	c.476G>T	c.(475-477)AGT>ATT	p.S159I	DTNA_uc002kxu.2_Missense_Mutation_p.S159I|DTNA_uc010xbx.1_Missense_Mutation_p.S159I|DTNA_uc002kxv.3_Missense_Mutation_p.S159I|DTNA_uc002kxw.2_Missense_Mutation_p.S159I|DTNA_uc002kxx.2_Missense_Mutation_p.S159I|DTNA_uc010dmj.2_Missense_Mutation_p.S159I|DTNA_uc002kxz.2_Missense_Mutation_p.S159I|DTNA_uc002kxy.2_Missense_Mutation_p.S159I|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.S159I|DTNA_uc002kyb.3_Missense_Mutation_p.S159I|DTNA_uc010dmm.2_Missense_Mutation_p.S159I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	159	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TCTGACTCCAGTGGGGTGATG	0.383			NA											32	24					2.08457e-15	2.53459e-15	0.010818	1	0
TCEB3B	51224	broad.mit.edu	37	18	44559566	44559566	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:44559566G>C	uc002lcr.1	-	1	2423	c.2070C>G	c.(2068-2070)AGC>AGG	p.S690R	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	690					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						caccgccgctgctgctCTGGC	0.537			NA											61	39					0	0	0.00361	0	0
ME2	4200	broad.mit.edu	37	18	48422209	48422209	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:48422209G>A	uc002ley.2	+	2	275	c.19G>A	c.(19-21)GTA>ATA	p.V7I	ME2_uc010dpd.2_Missense_Mutation_p.V7I	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	7					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	CCGGTTAAGAGTAGTTTCCAC	0.388			NA											28	17					0	0	0.00632	0	0
TCF4	6925	broad.mit.edu	37	18	52942913	52942913	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:52942913C>A	uc002lfz.2	-	10	1338	c.726G>T	c.(724-726)TTG>TTT	p.L242F	TCF4_uc002lfw.3_Missense_Mutation_p.L82F|TCF4_uc010xdu.1_Missense_Mutation_p.L112F|TCF4_uc010xdv.1_Missense_Mutation_p.L112F|TCF4_uc002lfx.2_Missense_Mutation_p.L171F|TCF4_uc010xdw.1_Missense_Mutation_p.L112F|TCF4_uc002lfy.2_Missense_Mutation_p.L200F|TCF4_uc010xdx.1_Missense_Mutation_p.L218F|TCF4_uc010dph.1_Missense_Mutation_p.L242F|TCF4_uc010xdy.1_Missense_Mutation_p.L218F|TCF4_uc002lga.2_Missense_Mutation_p.L344F|TCF4_uc002lgb.1_Missense_Mutation_p.L82F|TCF4_uc010dpi.2_Missense_Mutation_p.L248F|TCF4_uc002lgc.3_Missense_Mutation_p.L163F|TCF4_uc002lfv.2_Missense_Mutation_p.L26F	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	242					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AAGAGTTGCCCAACATTCCTG	0.502			NA											137	131					5.40711e-61	8.35799e-61	0.00361	1	0
SERPINB5	5268	broad.mit.edu	37	18	61154262	61154262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:61154262C>A	uc002liz.3	+	3	394	c.252C>A	c.(250-252)TAC>TAA	p.Y84*	SERPINB5_uc002liy.2_Nonsense_Mutation_p.Y84*	NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	84					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						GTTCCTTTTACTCACTGAAAC	0.338			NA											47	29					1.00776e-21	1.31155e-21	0.00361	1	0
SERPINB3	6317	broad.mit.edu	37	18	61323253	61323253	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:61323253T>G	uc002lji.2	-	8	955	c.811A>C	c.(811-813)AGT>CGT	p.S271R	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.S219R	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	271					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TTCTGCAAACTTGTCCATTCC	0.388			NA											15	70					0	0	0.003163	0	0
ATP9B	374868	broad.mit.edu	37	18	77105831	77105831	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr18:77105831G>A	uc002lmx.2	+	23	2688	c.2674G>A	c.(2674-2676)GAG>AAG	p.E892K	ATP9B_uc002lmw.1_Missense_Mutation_p.E892K|ATP9B_uc002lmz.1_Missense_Mutation_p.E586K|ATP9B_uc002lna.2_5'UTR|ATP9B_uc002lnb.1_Missense_Mutation_p.E12K|ATP9B_uc010drb.2_5'Flank	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	892	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		GATTGGGATTGAGGGAAAGGT	0.468			NA											57	183					0	0	0.00361	0	0
POLR2E	5434	broad.mit.edu	37	19	1094056	1094056	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:1094056G>C	uc002lre.3	-	2	156	c.79C>G	c.(79-81)CTG>GTG	p.L27V	POLR2E_uc010xgf.1_Intron	NM_002695	NP_002686	P19388	RPAB1_HUMAN	DNA directed RNA polymerase II polypeptide E	27					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGTCACCAGATAGCCACGG	0.637			NA											11	45					0	0	0.001368	0	0
DAZAP1	26528	broad.mit.edu	37	19	1434826	1434826	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:1434826G>T	uc002lsn.2	+	12	1328	c.1139G>T	c.(1138-1140)GGG>GTG	p.G380V	DAZAP1_uc002lsm.2_3'UTR|DAZAP1_uc002lso.2_Missense_Mutation_p.G379V|DAZAP1_uc002lsl.1_Missense_Mutation_p.G379V	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	380	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGTGCCAGGGTcggggggc	0.592			NA											22	18					1.22574e-08	1.35121e-08	0.002299	1	0
C19orf34	255193	broad.mit.edu	37	19	1954019	1954019	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:1954019G>T	uc002lum.2	-	2	473	c.16C>A	c.(16-18)CCT>ACT	p.P6T	CSNK1G2_uc002lul.3_Intron	NM_152771	NP_689984			chromosome 19 open reading frame 34												0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCTCCGAGGACCGGCCCTG	0.637			NA											122	99					1.22182e-49	1.84782e-49	0.00361	1	0
HDGFRP2	84717	broad.mit.edu	37	19	4498882	4498882	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:4498882G>A	uc002mao.2	+	13	1638	c.1545G>A	c.(1543-1545)AAG>AAA	p.K515K	HDGFRP2_uc002map.2_Silent_p.K515K|HDGFRP2_uc010dtz.1_RNA|HDGFRP2_uc010dua.2_5'Flank|HDGFRP2_uc002maq.1_5'Flank	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	515					transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						TCCTCCAGAAGAACACAGACG	0.637			NA											7	21					0	0	0.00308	0	0
TUBB4	10382	broad.mit.edu	37	19	6495195	6495195	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:6495195C>A	uc002mfg.1	-	4	1422	c.1315G>T	c.(1315-1317)GCG>TCG	p.A439S	TUBB4_uc002mff.1_Missense_Mutation_p.A367S|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	439					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		TCCTCCTCCGCCTCCTCCTCG	0.617			NA											64	32					5.10508e-28	7.04645e-28	0.00361	1	0
TRIP10	9322	broad.mit.edu	37	19	6750366	6750366	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:6750366G>A	uc002mfs.2	+	13	1525	c.1459G>A	c.(1459-1461)GCC>ACC	p.A487T	TRIP10_uc010dux.1_Missense_Mutation_p.A431T|TRIP10_uc002mfr.2_Missense_Mutation_p.A431T|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.A250T	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	487	Interaction with CDC42.|Interaction with PDE6G (By similarity).|Interaction with DNM2 and WASL (By similarity).|Required for interaction with FASLG and localization to lysosomes.			ARPPDPPASAPPD -> KHPIICRLIHFSN (in Ref. 10; AAC41729).	actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						GAGCCGGCACGCCCGGCCTCC	0.657			NA											7	105					0	0	0.001984	0	0
MYO1F	4542	broad.mit.edu	37	19	8615449	8615449	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:8615449C>A	uc002mkg.2	-	9	1015	c.901G>T	c.(901-903)GAC>TAC	p.D301Y	MYO1F_uc002mkh.2_Missense_Mutation_p.D301Y	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	301	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CACTCACGGTCCACACTCTCC	0.612			NA											33	19					7.11191e-15	8.52038e-15	0.002836	1	0
MUC16	94025	broad.mit.edu	37	19	9009594	9009594	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:9009594C>A	uc002mkp.2	-	39	39336	c.39132G>T	c.(39130-39132)CAG>CAT	p.Q13044H	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13046	Extracellular (Potential).|SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAACCAGACCCTGCAGGACCC	0.552			NA											145	75					2.78738e-67	4.36363e-67	0.00361	1	0
MUC16	94025	broad.mit.edu	37	19	9049824	9049824	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:9049824G>T	uc002mkp.2	-	5	32011	c.31807C>A	c.(31807-31809)CCT>ACT	p.P10603T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10605	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCTGCAGGATGGATAACC	0.478			NA											88	44					6.31949e-53	9.6017e-53	0.00361	1	0
MUC16	94025	broad.mit.edu	37	19	9073419	9073419	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:9073419G>A	uc002mkp.2	-	3	14231	c.14027C>T	c.(14026-14028)ACC>ATC	p.T4676I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4678	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTCATGTGGGTAGATATTGT	0.468			NA											107	74					0	0	0.00361	0	0
OR7E24	26648	broad.mit.edu	37	19	9362033	9362033	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:9362033C>A	uc002mlb.1	+	1	314	c.314C>A	c.(313-315)ACT>AAT	p.T105N		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	105	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GACATGCAAACTCACAGCAGA	0.498			NA											58	27					3.31993e-32	4.69485e-32	0.00361	1	0
S1PR2	9294	broad.mit.edu	37	19	10334521	10334521	+	Nonstop_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:10334521C>G	uc002mnl.2	-	2	1172	c.1061G>C	c.(1060-1062)TGA>TCA	p.*354S		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	354					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						CCCCCACCCTCAGACCACCGT	0.652	Pancreas(194;229 3020 15179 45747)		NA											14	41					0	0	0.003163	0	0
CDKN2D	1032	broad.mit.edu	37	19	10677815	10677815	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:10677815G>C	uc002mpa.2	-	2	722	c.420C>G	c.(418-420)CTC>CTG	p.L140L	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Silent_p.L140L	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	140	ANK 4.				anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CCAAGGGTGTGAGACCCCTGG	0.612			NA							Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				27	92					0	0	0.004656	0	0
ZNF791	163049	broad.mit.edu	37	19	12735466	12735466	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:12735466G>T	uc002mua.2	+	3	295	c.133G>T	c.(133-135)GAA>TAA	p.E45*	ZNF791_uc010xml.1_Nonsense_Mutation_p.E13*|ZNF791_uc010dyu.1_Intron|ZNF791_uc010xmm.1_5'UTR	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CATTTTAGGGGAAAAATGGGA	0.323			NA											6	18					0.00116845	0.00119778	0.001168	1	0
AKAP8L	26993	broad.mit.edu	37	19	15508056	15508056	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:15508056C>A	uc002naw.1	-	12	1540	c.1441G>T	c.(1441-1443)GCA>TCA	p.A481S	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.A420S	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	481						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CAATGGGCTGCCTCCACCTTC	0.547			NA											68	32					3.45129e-13	4.06522e-13	0.00361	1	0
CYP4F22	126410	broad.mit.edu	37	19	15648351	15648351	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:15648351G>T	uc002nbh.3	+	6	594	c.427G>T	c.(427-429)GGG>TGG	p.G143W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	143						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						CCCAGGGGATGGGCTGCTGCT	0.557			NA											64	32					2.36135e-34	3.38818e-34	0.00361	1	0
CYP4F8	11283	broad.mit.edu	37	19	15734818	15734818	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:15734818C>A	uc002nbi.2	+	11	1093	c.1029C>A	c.(1027-1029)AAC>AAA	p.N343K	CYP4F8_uc010xoj.1_Missense_Mutation_p.N155K	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	343					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TCTTGTACAACCTCGCGAGGC	0.602			NA											48	30					2.64894e-19	3.34101e-19	0.00361	1	0
PGLS	25796	broad.mit.edu	37	19	17628119	17628119	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:17628119C>T	uc002ngw.2	+	3	469	c.419C>T	c.(418-420)CCG>CTG	p.P140L		NM_012088	NP_036220	O95336	6PGL_HUMAN	6-phosphogluconolactonase	140						cytosol	6-phosphogluconolactonase activity				0						GACTCCATCCCGGTTTTCGAC	0.612			NA											155	91					0	0	0.00361	0	0
ZNF208	7757	broad.mit.edu	37	19	22157605	22157605	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:22157605T>C	uc002nqp.2	-	4	380	c.231A>G	c.(229-231)ATA>ATG	p.I77M	ZNF208_uc002nqo.1_Missense_Mutation_p.I77M|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AATGAGAACATATAACTGAAA	0.294			NA											30	13					0	0	0.007291	0	0
KCTD15	79047	broad.mit.edu	37	19	34291390	34291390	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:34291390T>C	uc002nuy.3	+	3	299	c.31T>C	c.(31-33)TCC>CCC	p.S11P	KCTD15_uc002nuv.2_Missense_Mutation_p.S11P|KCTD15_uc002nuw.3_Missense_Mutation_p.S11P|KCTD15_uc010xrt.1_Missense_Mutation_p.S11P|KCTD15_uc002nux.3_Missense_Mutation_p.S11P	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	11						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					GCCGAGCGGGTCCTCGCTTCA	0.637	Melanoma(36;646 1094 5145 14504 45302)|GBM(25;193 541 1518 14388 52178)		NA											9	52					0	0	0.008291	0	0
TMEM149	79713	broad.mit.edu	37	19	36230869	36230869	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:36230869G>A	uc002obc.2	-	4	564	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Nonsense_Mutation_p.Q155*|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Nonsense_Mutation_p.Q235*	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	155	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGGCCTGCTGAGGGACAGGC	0.622			NA											25	163					0	0	0.004656	0	0
APLP1	333	broad.mit.edu	37	19	36362795	36362795	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:36362795G>T	uc002oce.2	+	6	845	c.707G>T	c.(706-708)AGA>ATA	p.R236I	APLP1_uc010xsz.1_Missense_Mutation_p.R197I|APLP1_uc002ocf.2_Missense_Mutation_p.R236I|APLP1_uc002ocg.2_Missense_Mutation_p.R139I|APLP1_uc010xta.1_Missense_Mutation_p.R230I	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	236	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGGGGAGCAGAGTAGAGGGG	0.632			NA											35	245					9.17885e-22	1.19777e-21	0.003271	1	0
APLP1	333	broad.mit.edu	37	19	36362806	36362806	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:36362806G>T	uc002oce.2	+	6	856	c.718G>T	c.(718-720)GCT>TCT	p.A240S	APLP1_uc010xsz.1_Missense_Mutation_p.A201S|APLP1_uc002ocf.2_Missense_Mutation_p.A240S|APLP1_uc002ocg.2_Missense_Mutation_p.A143S|APLP1_uc010xta.1_Missense_Mutation_p.A234S	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	240	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGTAGAGGGGGCTGAGGACGA	0.642			NA											36	278					6.05902e-23	8.00248e-23	0.003755	1	0
ZNF585B	92285	broad.mit.edu	37	19	37676971	37676971	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:37676971C>G	uc002ofq.2	-	5	1722	c.1468G>C	c.(1468-1470)GGA>CGA	p.G490R	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.G304R	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATTTCTCTCCTGTATGAGTT	0.408	Melanoma(93;882 1454 18863 28917 48427)		NA											162	130					0	0	0.00361	0	0
ZNF607	84775	broad.mit.edu	37	19	38190240	38190240	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:38190240G>C	uc002ohc.1	-	5	1388	c.792C>G	c.(790-792)CTC>CTG	p.L264L	ZNF607_uc002ohb.1_Silent_p.L263L	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	264	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GGCCTGCTTTGAGCCTAAAGG	0.448			NA											14	104					0	0	0.001855	0	0
CATSPERG	57828	broad.mit.edu	37	19	38852329	38852329	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:38852329C>G	uc002oih.3	+	17	2009	c.1922C>G	c.(1921-1923)TCG>TGG	p.S641W	CATSPERG_uc002oig.3_Missense_Mutation_p.S601W|CATSPERG_uc002oif.3_Missense_Mutation_p.S281W|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	641	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TGCCCCTTCTCGGTGATGCGC	0.682			NA											3	146					0	0	0.004672	0	0
RYR1	6261	broad.mit.edu	37	19	38946102	38946102	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:38946102C>A	uc002oit.2	+	15	1718	c.1588C>A	c.(1588-1590)CGT>AGT	p.R530S	RYR1_uc002oiu.2_Missense_Mutation_p.R530S	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	530	Cytoplasmic.		R -> H (in MHS1).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTCTCTAATCCGTGGCAATCG	0.582			NA											65	163					1.33661e-31	1.87931e-31	0.00361	1	0
RYR1	6261	broad.mit.edu	37	19	38987127	38987127	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:38987127C>T	uc002oit.2	+	41	6872	c.6742C>T	c.(6742-6744)CGC>TGC	p.R2248C	RYR1_uc002oiu.2_Missense_Mutation_p.R2248C|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2248	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAGAACCAGCGCTCCATGTT	0.622			NA											63	191					0	0	0.00361	0	0
RYR1	6261	broad.mit.edu	37	19	39052027	39052027	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:39052027C>G	uc002oit.2	+	90	12687	c.12557C>G	c.(12556-12558)TCA>TGA	p.S4186*	RYR1_uc002oiu.2_Nonsense_Mutation_p.S4181*|RYR1_uc002oiv.1_Nonsense_Mutation_p.S1095*	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4186					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ATGGGCGCGTCACGCCGCATC	0.652			NA											18	198					0	0	0.006122	0	0
SARS2	54938	broad.mit.edu	37	19	39433327	39433327	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:39433327C>G	uc010xuq.1	-	5	471	c.263G>C	c.(262-264)AGA>ACA	p.R88T	FBXO17_uc002okg.1_Missense_Mutation_p.R253T|FBXO17_uc002okf.1_Missense_Mutation_p.R262T	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	Error:Variant_position_missing_in_Q9NP81_after_alignment					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACTCACGTCTCTCCCGTACTG	0.602			NA											26	214					0	0	0.005443	0	0
SUPT5H	6829	broad.mit.edu	37	19	39948326	39948326	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:39948326G>C	uc002olo.3	+	4	432	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	SUPT5H_uc010xvb.1_Missense_Mutation_p.E85Q|SUPT5H_uc002olp.3_Missense_Mutation_p.E85Q|SUPT5H_uc002olq.3_Missense_Mutation_p.E85Q|SUPT5H_uc002oln.3_Missense_Mutation_p.E85Q|SUPT5H_uc002olr.3_Missense_Mutation_p.E85Q	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	85	Glu-rich.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGTTGACGATGAGTATGAGGA	0.483			NA											28	136					0	0	0.010818	0	0
ZNF780A	284323	broad.mit.edu	37	19	40587775	40587775	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:40587775C>T	uc002omy.2	-	5	408	c.183G>A	c.(181-183)GAG>GAA	p.E61E	ZNF780A_uc002omw.3_Silent_p.E77E|ZNF780A_uc002omz.2_Silent_p.E61E|ZNF780A_uc010xvh.1_Silent_p.E62E	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGGGCTCTTTCTCTTGCTCTA	0.398			NA											23	96					0	0	0.00333	0	0
CIC	23152	broad.mit.edu	37	19	42798342	42798342	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:42798342G>T	uc002otf.1	+	18	4253	c.4213G>T	c.(4213-4215)GAG>TAG	p.E1405*		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TTCAGCACCCGAGGACCCCAC	0.627			NA	T	DUX4	soft tissue sarcoma								71	43					1.02016e-41	1.51478e-41	0.00361	1	0
ZNF233	353355	broad.mit.edu	37	19	44778564	44778564	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:44778564G>A	uc002oyz.1	+	5	1878	c.1751G>A	c.(1750-1752)AGA>AAA	p.R584K	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.R399K	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	584	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GCCCATCAGAGAGTCCACACA	0.458			NA											20	79					0	0	0.007413	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028255	45028255	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:45028255G>T	uc010ejn.1	-	3	252	c.236C>A	c.(235-237)GCC>GAC	p.A79D	CEACAM20_uc010ejo.1_Missense_Mutation_p.A79D|CEACAM20_uc010ejp.1_Missense_Mutation_p.A79D|CEACAM20_uc010ejq.1_Missense_Mutation_p.A79D	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	79	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CTGCTCTATGGCAGTGCCTGG	0.517			NA											44	37					1.8453e-21	2.39522e-21	0.010771	1	0
GRIN2D	2906	broad.mit.edu	37	19	48925050	48925050	+	Missense_Mutation	SNP	G	G	T	rs150071822		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:48925050G>T	uc002pjc.3	+	10	2188	c.2100G>T	c.(2098-2100)AGG>AGT	p.R700S	GRIN2D_uc010elx.2_5'UTR	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	700	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	AGTTCCAGAGGCCCCAGGAGC	0.582			NA											48	31					6.4308e-24	8.5744e-24	0.00361	1	0
NR1H2	7376	broad.mit.edu	37	19	50881788	50881788	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:50881788C>G	uc010enw.2	+	6	758	c.482C>G	c.(481-483)TCT>TGT	p.S161C	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.S161C|NR1H2_uc002psa.3_Missense_Mutation_p.S64C	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	161	Nuclear receptor.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GGCGTCCTTTCTGAAGAACAG	0.652			NA											28	82					0	0	0.009535	0	0
SHANK1	50944	broad.mit.edu	37	19	51219610	51219610	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:51219610G>A	uc002psx.1	-	2	400	c.381C>T	c.(379-381)CGC>CGT	p.R127R		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	127					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGTTGGCATCGCGGCCGGAGG	0.632			NA											24	80					0	0	0.00333	0	0
LILRA6	79168	broad.mit.edu	37	19	54744744	54744744	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:54744744C>A	uc002qeu.1	-	5	1042	c.918G>T	c.(916-918)TGG>TGT	p.W306C	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.W306C|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.W306C|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.W306C|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.W306C|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.W306C|LILRA6_uc010yeq.1_Missense_Mutation_p.W306C|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.W167C	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	306	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGGGCCGACCACTCGGAGG	0.687			NA											37	29					9.84934e-19	1.23748e-18	0.010771	1	0
LILRA3	11026	broad.mit.edu	37	19	54803705	54803705	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:54803705G>A	uc002qfd.2	-	3	184	c.119C>T	c.(118-120)ACC>ATC	p.T40I	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.T40I	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	40	Ig-like C2-type 1.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACTCCCTTGGGTGATCACAGA	0.537			NA											93	43					0	0	0.00361	0	0
LILRA2	11027	broad.mit.edu	37	19	55086396	55086396	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:55086396C>A	uc002qgg.3	+	4	640	c.551C>A	c.(550-552)CCC>CAC	p.P184H	LILRA2_uc010ern.2_Missense_Mutation_p.P184H|LILRA2_uc002qgf.2_Missense_Mutation_p.P184H|LILRA2_uc010yfe.1_Missense_Mutation_p.P184H|LILRA2_uc010yff.1_Missense_Mutation_p.P172H|LILRA2_uc010ero.2_Missense_Mutation_p.P172H|LILRA2_uc010yfg.1_Missense_Mutation_p.P184H	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	184	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TCCGTGGGCCCCGTGAGCCCG	0.577			NA											122	241					1.30845e-55	2.00044e-55	0.00361	1	0
KIR2DL3	3804	broad.mit.edu	37	19	55258819	55258819	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:55258819G>A	uc002qgv.2	+	5	715	c.697G>A	c.(697-699)GAA>AAA	p.E233K	KIR2DL3_uc002qgx.2_Missense_Mutation_p.E233K|KIR2DL3_uc002qgy.2_Missense_Mutation_p.E135K|KIR2DL3_uc010erw.1_Missense_Mutation_p.E233K|KIR2DL1_uc002qgz.1_Missense_Mutation_p.E143K|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	233	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		TTCACCCACTGAACCAAGCTC	0.488			NA											82	461					0	0	0.00361	0	0
NLRP7	199713	broad.mit.edu	37	19	55451427	55451427	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:55451427C>A	uc002qih.3	-	4	836	c.760G>T	c.(760-762)GGC>TGC	p.G254C	NLRP7_uc002qig.3_Missense_Mutation_p.G254C|NLRP7_uc002qii.3_Missense_Mutation_p.G254C|NLRP7_uc010esk.2_Missense_Mutation_p.G254C|NLRP7_uc010esl.2_Missense_Mutation_p.G282C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	254	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCATCAAGGCCATCGACCACG	0.562			NA											106	162					2.14364e-31	3.00969e-31	0.00361	1	0
ZNF524	147807	broad.mit.edu	37	19	56114130	56114130	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:56114130A>G	uc002qlk.1	+	2	735	c.652A>G	c.(652-654)AAG>GAG	p.K218E	FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	218	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GCGCCATGCGAAGCGCAAGCA	0.706			NA											35	49					0	0	0.004289	0	0
NLRP8	126205	broad.mit.edu	37	19	56482046	56482046	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:56482046C>A	uc002qmh.2	+	6	2589	c.2518C>A	c.(2518-2520)CAG>AAG	p.Q840K	NLRP8_uc010etg.2_Missense_Mutation_p.Q840K	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	840	LRR 3.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTCTGTGGCCCAGCTGGAGAG	0.463			NA											140	244					4.34486e-62	6.72664e-62	0.00361	1	0
NLRP5	126206	broad.mit.edu	37	19	56539809	56539809	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:56539809G>T	uc002qmj.2	+	7	2210	c.2210G>T	c.(2209-2211)CGG>CTG	p.R737L	NLRP5_uc002qmi.2_Missense_Mutation_p.R718L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	737	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CGGAAAATTCGGGTGGATGTC	0.502			NA											71	373					2.40655e-23	3.19137e-23	0.00361	1	0
NLRP5	126206	broad.mit.edu	37	19	56572830	56572830	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:56572830G>A	uc002qmj.2	+	15	3539	c.3539G>A	c.(3538-3540)CGA>CAA	p.R1180Q	NLRP5_uc002qmi.2_Missense_Mutation_p.R1161Q	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	1180						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTCAAGCCCCGAGTCGTAATT	0.512			NA											44	102					0	0	0.013114	0	0
ZIM2	23619	broad.mit.edu	37	19	57286456	57286456	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57286456T>A	uc002qnr.2	-	11	1566	c.1184A>T	c.(1183-1185)CAG>CTG	p.Q395L	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.Q191L|ZIM2_uc010ygr.1_Missense_Mutation_p.Q191L|ZIM2_uc002qnq.2_Missense_Mutation_p.Q395L|ZIM2_uc010etp.2_Missense_Mutation_p.Q395L|ZIM2_uc010ygs.1_Missense_Mutation_p.Q395L	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ATTCGCACACTGGACGGAAGG	0.463			NA											55	96					0	0	0.00361	0	0
PEG3	5178	broad.mit.edu	37	19	57325561	57325561	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57325561C>T	uc002qnu.2	-	7	4600	c.4249G>A	c.(4249-4251)GAG>AAG	p.E1417K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1388K|PEG3_uc002qnv.2_Missense_Mutation_p.E1417K|PEG3_uc002qnw.2_Missense_Mutation_p.E1293K|PEG3_uc002qnx.2_Missense_Mutation_p.E1291K|PEG3_uc010etr.2_Missense_Mutation_p.E1417K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1417	Glu-rich.|3 X 7 AA repeat of P-E-V-E-A-A-E.|2-3.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCGTTTGGCTCAGCAGCCTCC	0.597			NA											35	168					0	0	0.003271	0	0
PEG3	5178	broad.mit.edu	37	19	57326225	57326225	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57326225C>T	uc002qnu.2	-	7	3936	c.3585G>A	c.(3583-3585)GGG>GGA	p.G1195G	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.G1166G|PEG3_uc002qnv.2_Silent_p.G1195G|PEG3_uc002qnw.2_Silent_p.G1071G|PEG3_uc002qnx.2_Silent_p.G1069G|PEG3_uc010etr.2_Silent_p.G1195G	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1195					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CATCATCACACCCCTTCATGG	0.468			NA											73	135					0	0	0.00361	0	0
PEG3	5178	broad.mit.edu	37	19	57328907	57328907	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57328907C>A	uc002qnu.2	-	7	1254	c.903G>T	c.(901-903)CGG>CGT	p.R301R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.R272R|PEG3_uc002qnv.2_Silent_p.R301R|PEG3_uc002qnw.2_Silent_p.R177R|PEG3_uc002qnx.2_Silent_p.R175R|PEG3_uc010etr.2_Silent_p.R301R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	301					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAATCCCCCGCCGGTGGGTTG	0.453			NA											96	147					2.19198e-39	3.20139e-39	0.00361	1	0
DUXA	503835	broad.mit.edu	37	19	57672164	57672164	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57672164C>A	uc002qoa.1	-	2	72	c.27G>T	c.(25-27)AAG>AAT	p.K9N		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	9						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TTTTTACCATCTCTGTAGGAA	0.373			NA											52	30					1.54886e-18	1.93855e-18	0.00361	1	0
ZNF805	390980	broad.mit.edu	37	19	57765287	57765287	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:57765287G>T	uc010ygt.1	+	4	1307	c.1100G>T	c.(1099-1101)GGG>GTG	p.G367V	ZNF805_uc010ygu.1_Missense_Mutation_p.G234V	NM_001023563	NP_001018857	Q5CZA5	ZN805_HUMAN	zinc finger protein 805 isoform 1	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTCATACCGGGGAGAAGCCC	0.517			NA											6	60					0.00116845	0.00119778	0.001168	1	0
TSSC1	7260	broad.mit.edu	37	2	3193150	3193150	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:3193150C>A	uc002qxj.2	-	9	1312	c.1119G>T	c.(1117-1119)GTG>GTT	p.V373V	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	373	WD 5.						protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CCCTGTTGATCACGAGCCTCC	0.602	Colon(140;1261 1762 4183 34270 49743)		NA											19	14					5.35267e-07	5.82199e-07	0.007413	1	0
CPSF3	51692	broad.mit.edu	37	2	9572814	9572814	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:9572814G>A	uc002qzo.1	+	5	551	c.516G>A	c.(514-516)GTG>GTA	p.V172V	CPSF3_uc010ewx.1_Silent_p.V172V|CPSF3_uc002qzp.1_Silent_p.V135V	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	172					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TCGCAGGCGTGAAGGTACCCT	0.458	Colon(194;1259 2048 3845 5218 19985)		NA											4	77					0	0	0.009096	0	0
APOB	338	broad.mit.edu	37	2	21230494	21230494	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:21230494G>T	uc002red.2	-	26	9374	c.9246C>A	c.(9244-9246)GCC>GCA	p.A3082A		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3082					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGCTTGCTGGGCACTGGGAC	0.413			NA											145	66					5.77923e-69	9.06184e-69	0.00361	1	0
GCKR	2646	broad.mit.edu	37	2	27726468	27726468	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:27726468G>T	uc002rky.2	+	9	798	c.732G>T	c.(730-732)GTG>GTT	p.V244V	GCKR_uc010ezd.2_Silent_p.V244V|GCKR_uc010ylu.1_Silent_p.V54V	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	244	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					AAGCTTTTGTGCTCAATCCTG	0.502			NA											34	20					1.26612e-14	1.51316e-14	0.003271	1	0
FOSL2	2355	broad.mit.edu	37	2	28635205	28635205	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:28635205G>C	uc002rma.2	+	4	1680	c.871G>C	c.(871-873)GAG>CAG	p.E291Q	FOSL2_uc010ymi.1_Missense_Mutation_p.E252Q	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	291					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CCTGGAGCAGGAGTCACCCGC	0.612			NA											45	76					0	0	0.009718	0	0
CAPN13	92291	broad.mit.edu	37	2	30998891	30998891	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:30998891C>T	uc002rnn.2	-	4	468	c.292G>A	c.(292-294)GCA>ACA	p.A98T	CAPN13_uc002rnp.1_Missense_Mutation_p.A98T	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	98	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GATCCCAGTGCTGCCAGGAAC	0.517			NA											9	90					0	0	0.006214	0	0
GALNT14	79623	broad.mit.edu	37	2	31215713	31215713	+	Missense_Mutation	SNP	C	C	T	rs113322802		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:31215713C>T	uc002rnr.2	-	2	909	c.290G>A	c.(289-291)CGC>CAC	p.R97H	GALNT14_uc002rnq.2_Missense_Mutation_p.R77H|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R62H|GALNT14_uc010ezo.1_Missense_Mutation_p.R97H|GALNT14_uc010ezp.1_Missense_Mutation_p.R68H	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	97	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					CCTCAGATGGCGAGTGTCCGG	0.567			NA											13	224					0	0	0.003163	0	0
BIRC6	57448	broad.mit.edu	37	2	32694557	32694557	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:32694557A>G	uc010ezu.2	+	30	6356	c.6222A>G	c.(6220-6222)ATA>ATG	p.I2074M		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2074					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCCCAAAGATACGGTTACATA	0.443	Pancreas(94;175 1509 16028 18060 45422)		NA											76	209					0	0	0.00361	0	0
LTBP1	4052	broad.mit.edu	37	2	33246069	33246069	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:33246069C>A	uc002ros.2	+	3	659	c.659C>A	c.(658-660)ACA>AAA	p.T220K		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	220					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GCCTGTGAAACAATAGCTGCC	0.567			NA											222	167					1.77857e-91	2.81129e-91	0.00361	1	0
SULT6B1	391365	broad.mit.edu	37	2	37414550	37414550	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:37414550T>A	uc002rpu.2	-	2	167	c.146A>T	c.(145-147)TAT>TTT	p.Y49F	SULT6B1_uc010yni.1_RNA	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member	87						cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				TGGATATTTATACTTTTTTTT	0.323			NA											26	20					0	0	0.00361	0	0
NRXN1	9378	broad.mit.edu	37	2	50724658	50724658	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:50724658C>A	uc010fbq.2	-	14	4289	c.2812G>T	c.(2812-2814)GGC>TGC	p.G938C	NRXN1_uc002rxb.3_Missense_Mutation_p.G570C|NRXN1_uc002rxe.3_Missense_Mutation_p.G898C|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTCCTGAAGCCAAATCTGGCA	0.418			NA											62	38					3.30226e-22	4.33228e-22	0.00361	1	0
ERLEC1	27248	broad.mit.edu	37	2	54041746	54041746	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:54041746T>A	uc002rxl.2	+	12	1573	c.1293T>A	c.(1291-1293)ACT>ACA	p.T431T	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Intron|ERLEC1_uc002rxn.2_Silent_p.T377T	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	431					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						GACAGGTGACTGTAAAACTAA	0.318			NA											28	23					0	0	0.009535	0	0
AFTPH	54812	broad.mit.edu	37	2	64778637	64778637	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:64778637C>G	uc002sdc.2	+	1	61	c.29C>G	c.(28-30)TCT>TGT	p.S10C	AFTPH_uc002scz.2_Missense_Mutation_p.S10C|AFTPH_uc002sda.2_Missense_Mutation_p.S10C|AFTPH_uc002sdb.2_Missense_Mutation_p.S10C	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	10					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						CGAATGTACTCTTCATCCCCA	0.393			NA											16	182					0	0	0.004007	0	0
CCDC142	84865	broad.mit.edu	37	2	74709037	74709037	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:74709037A>C	uc002slr.2	-	1	1321	c.928T>G	c.(928-930)TGG>GGG	p.W310G	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.W310G|CCDC142_uc002slp.2_Missense_Mutation_p.W310G	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	310										central_nervous_system(1)	1						CAGGCTGCCCACAGCAGGGTC	0.662			NA											16	129					0	0	0.00499	0	0
DNAH6	1768	broad.mit.edu	37	2	84780069	84780069	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:84780069G>A	uc010fgb.2	+	10	1650	c.1513G>A	c.(1513-1515)GAA>AAA	p.E505K	DNAH6_uc002soo.2_Missense_Mutation_p.E84K|DNAH6_uc002sop.2_Missense_Mutation_p.E84K	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	505	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						AAAGCAAGAAGAAGATGAATC	0.383			NA											6	134					0	0	0.001984	0	0
RETSAT	54884	broad.mit.edu	37	2	85571210	85571210	+	Missense_Mutation	SNP	C	C	A	rs147993013		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:85571210C>A	uc002spd.2	-	9	1636	c.1445G>T	c.(1444-1446)CGG>CTG	p.R482L	RETSAT_uc010fge.2_Intron|RETSAT_uc010ysm.1_Missense_Mutation_p.R421L|RETSAT_uc010fgf.2_Missense_Mutation_p.R273L	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	482					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	GTCACTGCCCCGCTTTCCCTT	0.537			NA											89	46					8.6838e-40	1.27588e-39	0.00361	1	0
C2orf51	200523	broad.mit.edu	37	2	88828748	88828748	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:88828748G>T	uc002stb.1	+	4	441	c.299G>T	c.(298-300)CGC>CTC	p.R100L		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	100						nucleus				skin(1)	1						GAGGACGAGCGCAAGTTCACC	0.587			NA											25	195					5.45024e-15	6.56978e-15	0.00333	1	0
C2orf51	200523	broad.mit.edu	37	2	88828927	88828927	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:88828927C>T	uc002stb.1	+	4	620	c.478C>T	c.(478-480)CAT>TAT	p.H160Y		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	160						nucleus				skin(1)	1						TCCCTGTCTTCATTGCCATAT	0.532			NA											32	102					0	0	0.003271	0	0
PROM2	150696	broad.mit.edu	37	2	95952274	95952274	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:95952274C>T	uc002suh.1	+	17	2128	c.1995C>T	c.(1993-1995)CTC>CTT	p.L665L	PROM2_uc002sui.2_Silent_p.L665L|PROM2_uc002suj.2_Silent_p.L319L|PROM2_uc002suk.2_Silent_p.L665L|PROM2_uc002sul.2_Silent_p.L191L|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	665	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						CCCAAGGACTCAGAAACCTTC	0.627			NA											29	106					0	0	0.003271	0	0
VWA3B	200403	broad.mit.edu	37	2	98709643	98709643	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:98709643G>T	uc002syo.2	+	2	352	c.88G>T	c.(88-90)GAG>TAG	p.E30*	VWA3B_uc010yvh.1_5'UTR|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Nonsense_Mutation_p.E30*|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	30										ovary(3)|large_intestine(2)|skin(1)	6						AGACTTGGCTGAGCAGAGTCT	0.453			NA											20	115					4.63292e-17	5.76176e-17	0.008871	1	0
IL1F8	27177	broad.mit.edu	37	2	113788630	113788630	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:113788630T>A	uc002tiq.1	-	3	220	c.116A>T	c.(115-117)AAG>ATG	p.K39M	IL1F8_uc002tir.1_Missense_Mutation_p.K39M	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	39					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CTCACCAGGCTTAATGCTGCG	0.507			NA											41	37					0	0	0.013114	0	0
CCDC93	54520	broad.mit.edu	37	2	118706927	118706927	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:118706927G>A	uc002tlj.2	-	14	1239	c.1113C>T	c.(1111-1113)CTC>CTT	p.L371L	CCDC93_uc010fld.1_Silent_p.L371L	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	371	Potential.									large_intestine(1)|ovary(1)	2						CTATCTTCTCGAGGGCTGCTT	0.433			NA											7	145					0	0	0.00308	0	0
GLI2	2736	broad.mit.edu	37	2	121747580	121747580	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:121747580G>A	uc010flp.2	+	13	4120	c.4090G>A	c.(4090-4092)GCA>ACA	p.A1364T	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.A1036T|GLI2_uc002tmu.3_Missense_Mutation_p.A1019T	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1364					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGTGGCTACAGCAGGCTTTGG	0.697			NA											7	31					0	0	0.00308	0	0
MKI67IP	84365	broad.mit.edu	37	2	122493196	122493196	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:122493196C>A	uc002tnk.2	-	2	313	c.236G>T	c.(235-237)AGT>ATT	p.S79I	MKI67IP_uc010fls.2_Missense_Mutation_p.S79I	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	79	RRM.				protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TACCCTTTTACTTCTGGACAG	0.393			NA											7	73					7.48243e-07	8.12047e-07	0.006214	1	0
TUBA3E	112714	broad.mit.edu	37	2	130951518	130951518	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:130951518G>T	uc002tqv.2	-	4	998	c.897C>A	c.(895-897)GCC>GCA	p.A299A		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	299					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CCATCTGATTGGCTGGCTCGA	0.597			NA											151	111					1.95521e-66	3.05598e-66	0.00361	1	0
YSK4	80122	broad.mit.edu	37	2	135745613	135745613	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:135745613G>A	uc002tue.1	-	7	860	c.829C>T	c.(829-831)CTC>TTC	p.L277F	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.L164F|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.L5F|YSK4_uc002tui.3_Missense_Mutation_p.L294F	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	277							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAAGACCTGAGAGTCGGATCC	0.478			NA											43	121					0	0	0.007835	0	0
LRP1B	53353	broad.mit.edu	37	2	141135754	141135754	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:141135754C>G	uc002tvj.1	-	68	11605	c.10633G>C	c.(10633-10635)GAT>CAT	p.D3545H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3545	Extracellular (Potential).|LDL-receptor class A 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTACCTCATCAGAGCCATCT	0.413	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			3	89					0	0	0.004672	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144381793	144381793	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:144381793G>T	uc002tvm.3	+	12	1246	c.1095G>T	c.(1093-1095)CCG>CCT	p.P365P	ARHGAP15_uc002tvn.2_Silent_p.P131P	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	365	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGCCTGAGCCGCTCTTCCCTT	0.488			NA											54	31					9.57592e-29	1.32736e-28	0.00361	1	0
MBD5	55777	broad.mit.edu	37	2	149243347	149243347	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:149243347A>G	uc002twm.3	+	11	3870	c.2882A>G	c.(2881-2883)CAT>CGT	p.H961R	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.H961R|MBD5_uc002two.2_Missense_Mutation_p.H219R|MBD5_uc002twp.2_Missense_Mutation_p.H11R	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	961						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TTGAGTAACCATCAACTGACT	0.383			NA											6	51					0	0	0.001168	0	0
NEB	4703	broad.mit.edu	37	2	152543993	152543993	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:152543993G>A	uc010fnx.2	-	27	2768	c.2577C>T	c.(2575-2577)CTC>CTT	p.L859L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	859	Nebulin 20.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATTAATGCTGAGGGCTCCAA	0.438			NA											93	256					0	0	0.00361	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711521	155711521	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:155711521C>G	uc002tyv.1	+	3	1397	c.1202C>G	c.(1201-1203)TCT>TGT	p.S401C	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	401	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AAACTACCATCTAAGCTGCAG	0.398			NA											9	226					0	0	0.004482	0	0
PLA2R1	22925	broad.mit.edu	37	2	160813066	160813066	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:160813066C>T	uc002ube.1	-	21	3184	c.2977G>A	c.(2977-2979)GAA>AAA	p.E993K	PLA2R1_uc010zcp.1_Missense_Mutation_p.E993K|PLA2R1_uc002ubf.2_Missense_Mutation_p.E993K	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	993	Extracellular (Potential).|C-type lectin 6.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CCCCCTTCTTCAGCACAGAAA	0.433			NA											6	112					0	0	0.001168	0	0
PLA2R1	22925	broad.mit.edu	37	2	160813073	160813073	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:160813073G>A	uc002ube.1	-	21	3177	c.2970C>T	c.(2968-2970)TTC>TTT	p.F990F	PLA2R1_uc010zcp.1_Silent_p.F990F|PLA2R1_uc002ubf.2_Silent_p.F990F	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	990	Extracellular (Potential).|C-type lectin 6.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTTCAGCACAGAAATGTTGAG	0.438			NA											5	117					0	0	0.001168	0	0
GCG	2641	broad.mit.edu	37	2	163004015	163004015	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:163004015T>A	uc002ucc.2	-	3	201	c.102A>T	c.(100-102)TCA>TCT	p.S34S		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	34					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	CCTGGGAAGCTGAGAATGATC	0.448			NA											112	283					0	0	0.00361	0	0
SCN9A	6335	broad.mit.edu	37	2	167108323	167108323	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:167108323C>T	uc010fpl.2	-	18	3732	c.3391G>A	c.(3391-3393)GAG>AAG	p.E1131K	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1142						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GGTTCAGCCTCTGCTTCTTCT	0.473			NA											4	85					0	0	0.009096	0	0
CHN1	1123	broad.mit.edu	37	2	175779854	175779854	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:175779854A>C	uc002uji.2	-	5	722	c.192T>G	c.(190-192)ATT>ATG	p.I64M	CHN1_uc010zeq.1_Missense_Mutation_p.I64M|CHN1_uc002ujj.2_Translation_Start_Site	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	64	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCTCAGCCACAATCAAGAGCT	0.478			NA	T	TAF15	extraskeletal myxoid chondrosarcoma								13	36					0	0	0.001368	0	0
DFNB59	494513	broad.mit.edu	37	2	179325880	179325880	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:179325880G>A	uc002umi.3	+	7	1294	c.938G>A	c.(937-939)GGA>GAA	p.G313E	DFNB59_uc002umj.3_Missense_Mutation_p.G313E	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	313					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			ATACTCTGTGGAATGGGGAAC	0.413			NA											67	187					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179648873	179648873	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:179648873T>A	uc010zfg.1	-	16	2923	c.2699A>T	c.(2698-2700)AAG>ATG	p.K900M	TTN_uc010zfh.1_Missense_Mutation_p.K854M|TTN_uc010zfi.1_Missense_Mutation_p.K854M|TTN_uc010zfj.1_Missense_Mutation_p.K854M|TTN_uc002unb.2_Missense_Mutation_p.K900M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	900							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTACTTCCTTTTTCACCTC	0.547			NA											50	158					0	0	0.00361	0	0
CCDC141	285025	broad.mit.edu	37	2	179736888	179736888	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:179736888C>A	uc002unf.1	-	3	383	c.326G>T	c.(325-327)TGG>TTG	p.W109L		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	109	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAATGCCGCCCACTGCTGTTT	0.383			NA											39	42					1.04594e-18	1.31077e-18	0.00623	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802298	185802298	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:185802298G>A	uc002uph.2	+	4	2769	c.2175G>A	c.(2173-2175)TGG>TGA	p.W725*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	725						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						ACTGTTGTTGGAAAACCAAAA	0.323			NA											24	85					0	0	0.002299	0	0
COL3A1	1281	broad.mit.edu	37	2	189871112	189871112	+	Silent	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:189871112T>G	uc002uqj.1	+	43	3252	c.3135T>G	c.(3133-3135)GCT>GCG	p.A1045A		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1045	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCCCTGGCGCTCCTGGTCATC	0.478			NA											25	92					0	0	0.003954	0	0
COL5A2	1290	broad.mit.edu	37	2	189916209	189916209	+	Splice_Site	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:189916209T>A	uc002uqk.2	-	42	3045	c.2770_splice	c.e42-1	p.G924_splice	COL5A2_uc010frx.2_Splice_Site_p.G500_splice	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TGGAGCTCCCTAGTATAACAA	0.562			NA											15	65					0	0	0.004007	0	0
HIBCH	26275	broad.mit.edu	37	2	191116925	191116925	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:191116925C>G	uc002uru.2	-	8	709	c.626G>C	c.(625-627)AGA>ACA	p.R209T	HIBCH_uc002urv.2_Missense_Mutation_p.R209T	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	209					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			AATTCCTGCTCTGTACACATC	0.388			NA											15	111					0	0	0.00499	0	0
PGAP1	80055	broad.mit.edu	37	2	197706049	197706049	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:197706049C>T	uc002utw.2	-	27	2792	c.2678G>A	c.(2677-2679)GGT>GAT	p.G893D	PGAP1_uc002utx.2_Missense_Mutation_p.G719D|PGAP1_uc010fsi.2_Missense_Mutation_p.G132D	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	893	Cytoplasmic (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						AGCAATCACACCAACAGCCAG	0.368			NA											19	74					0	0	0.010504	0	0
AOX1	316	broad.mit.edu	37	2	201523948	201523948	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:201523948G>A	uc002uvx.2	+	28	3333	c.3232G>A	c.(3232-3234)GAA>AAA	p.E1078K	AOX1_uc010zhf.1_Missense_Mutation_p.E634K|AOX1_uc010fsu.2_Missense_Mutation_p.E444K	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1078					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AACAAGCACAGAAACTGTCCC	0.438			NA											8	204					0	0	0.00308	0	0
NIF3L1	60491	broad.mit.edu	37	2	201761901	201761901	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:201761901C>G	uc002uwm.2	+	5	920	c.829C>G	c.(829-831)CAT>GAT	p.H277D	NIF3L1_uc002uwl.2_Missense_Mutation_p.H250D|NIF3L1_uc002uwn.2_Missense_Mutation_p.H250D|NIF3L1_uc002uwo.2_Missense_Mutation_p.H277D|NIF3L1_uc002uwp.2_Missense_Mutation_p.H277D|NIF3L1_uc002uwq.2_Intron	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	277					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						AAAACTATCTCATATTCGCTT	0.423			NA											34	139					0	0	0.003271	0	0
NRP2	8828	broad.mit.edu	37	2	206610568	206610569	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:206610568_206610569GG>AT	uc002vaw.2	+	10	2531_2532	c.1740_1741GG>AT	c.(1738-1743)CCGGCG>CCATCG	p.A581S	NRP2_uc002vau.2_Missense_Mutation_p.A581S|NRP2_uc002vav.2_Missense_Mutation_p.A581S|NRP2_uc002vax.2_Missense_Mutation_p.A581S|NRP2_uc002vay.2_Missense_Mutation_p.A581S	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	581	Extracellular (Potential).|F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTGGTCGCCGGCGGGGATTGG	0.579			NA											54	50					0	0	0.004672	0	0
INO80D	54891	broad.mit.edu	37	2	206869607	206869607	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:206869607C>A	uc002vaz.3	-	11	2974	c.2569G>T	c.(2569-2571)GCA>TCA	p.A857S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	857					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						AAGGTAGCTGCCATATTATCA	0.527			NA											63	165					4.45325e-31	6.22566e-31	0.00361	1	0
ADAM23	8745	broad.mit.edu	37	2	207452876	207452876	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:207452876C>A	uc002vbq.2	+	20	2073	c.1850C>A	c.(1849-1851)ACA>AAA	p.T617K	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	617	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		ATCTGGGGAACAAGTAGGTCG	0.522	Melanoma(194;1127 2130 19620 24042 27855)		NA											43	85					7.63091e-17	9.44229e-17	0.007835	1	0
FASTKD2	22868	broad.mit.edu	37	2	207652733	207652733	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:207652733G>C	uc002vbu.2	+	9	2077	c.1667G>C	c.(1666-1668)AGG>ACG	p.R556T	FASTKD2_uc002vbv.2_Missense_Mutation_p.R556T|FASTKD2_uc002vbx.2_Missense_Mutation_p.R556T|FASTKD2_uc002vbw.1_Missense_Mutation_p.R556T	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	556					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		GTCTATCTGAGGGACATAGCC	0.453			NA											21	70					0	0	0.010504	0	0
SPAG16	79582	broad.mit.edu	37	2	214794788	214794788	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:214794788G>T	uc002veq.2	+	12	1411	c.1319G>T	c.(1318-1320)TGG>TTG	p.W440L	SPAG16_uc010fuz.1_Missense_Mutation_p.W291L|SPAG16_uc002ver.2_Missense_Mutation_p.W386L|SPAG16_uc010zjk.1_Missense_Mutation_p.W346L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	440	WD 3.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CGCGCAGTGTGGTCCTGCACA	0.428			NA											76	59					4.09166e-32	5.77785e-32	0.00361	1	0
TMEM169	92691	broad.mit.edu	37	2	216965125	216965125	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:216965125T>C	uc010zjr.1	+	4	1080	c.754T>C	c.(754-756)TTC>CTC	p.F252L	TMEM169_uc010zjs.1_Missense_Mutation_p.F252L|TMEM169_uc002vfw.2_Missense_Mutation_p.F252L|TMEM169_uc002vfv.3_Missense_Mutation_p.F252L	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	252	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGAAAGGCTTCTGTGGCTG	0.572			NA											79	233					0	0	0.00361	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279574	217279574	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:217279574C>T	uc002vgc.3	+	3	477	c.147C>T	c.(145-147)GCC>GCT	p.A49A	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Silent_p.A49A|SMARCAL1_uc010fvg.2_Silent_p.A49A	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	49					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CATTCCAGGCCAAGCAAGGCC	0.512			NA							Schimke_Immuno-Osseous_Dysplasia				168	165					0	0	0.00361	0	0
TNS1	7145	broad.mit.edu	37	2	218686627	218686627	+	Silent	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:218686627T>G	uc002vgt.2	-	23	3494	c.3096A>C	c.(3094-3096)ACA>ACC	p.T1032T	TNS1_uc002vgr.2_Silent_p.T1019T|TNS1_uc002vgs.2_Silent_p.T1011T|TNS1_uc010zjv.1_Silent_p.T1011T	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1032						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CAGCCACCGCTGTCCGTGCCA	0.637			NA											8	5					0	0	0.004482	0	0
SPEG	10290	broad.mit.edu	37	2	220355508	220355508	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:220355508G>T	uc010fwg.2	+	38	9215	c.9215G>T	c.(9214-9216)GGC>GTC	p.G3072V		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	3072	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTGCTACAAGGCCTGGACTAC	0.597			NA											82	95					6.71967e-41	9.93254e-41	0.00361	1	0
OBSL1	23363	broad.mit.edu	37	2	220423027	220423027	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:220423027C>A	uc010fwk.2	-	10	3438	c.3381G>T	c.(3379-3381)CTG>CTT	p.L1127L	OBSL1_uc002vmh.1_Silent_p.L118L|OBSL1_uc010zli.1_Intron|OBSL1_uc010fwl.1_Silent_p.L602L	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1127	Ig-like 9.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CACCCAGCTGCAGGGCATCTG	0.697			NA											14	30					1.3612e-06	1.46752e-06	0.003163	1	0
COL4A4	1286	broad.mit.edu	37	2	228004950	228004950	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:228004950C>A	uc010zlt.1	-	4	773	c.119G>T	c.(118-120)GGA>GTA	p.G40V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	40	7S domain.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTATTTCTTTCCACTCTGGAA	0.413			NA											26	107					4.7796e-09	5.29866e-09	0.004656	1	0
COL4A3	1285	broad.mit.edu	37	2	228137787	228137787	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:228137787G>C	uc002vom.1	+	26	2043	c.1881G>C	c.(1879-1881)CAG>CAC	p.Q627H	COL4A3_uc002von.1_Missense_Mutation_p.Q627H|COL4A3_uc002voo.1_Missense_Mutation_p.Q627H|COL4A3_uc002vop.1_Missense_Mutation_p.Q627H|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	627	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CTGGTCTCCAGGGCACGCAAG	0.617			NA											33	129					0	0	0.003755	0	0
TM4SF20	79853	broad.mit.edu	37	2	228228599	228228599	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:228228599G>A	uc002vpb.2	-	4	569	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_024795	NP_079071	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	177	Extracellular (Potential).					integral to membrane|plasma membrane					0		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CTTCAGAATCGAAGTGGAAAC	0.438			NA											7	174					0	0	0.00308	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881688	228881688	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:228881688C>G	uc002vpq.2	-	7	3929	c.3882G>C	c.(3880-3882)CGG>CGC	p.R1294R	SPHKAP_uc002vpp.2_Silent_p.R1294R|SPHKAP_uc010zlx.1_Silent_p.R1294R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1294						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCCCACCTCTCCGATACAAGC	0.498			NA											4	165					0	0	0.000602	0	0
SP110	3431	broad.mit.edu	37	2	231067329	231067329	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:231067329C>T	uc002vqh.3	-	9	1254	c.1014G>A	c.(1012-1014)GCG>GCA	p.A338A	SP110_uc002vqg.3_Silent_p.A338A|SP110_uc002vqi.3_Silent_p.A338A|SP110_uc010fxk.2_Silent_p.A336A|SP110_uc010fxj.2_Intron	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	338					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		ATTCAGTTCTCGCCTTTTGGG	0.493			NA											34	112					0	0	0.012213	0	0
USP40	55230	broad.mit.edu	37	2	234421213	234421213	+	Splice_Site	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:234421213A>G	uc010zmr.1	-	18	2470	c.2470_splice	c.e18+1	p.V824_splice	USP40_uc002vun.2_5'Flank|USP40_uc002vuo.1_5'Flank|USP40_uc010zmt.1_Splice_Site_p.V468_splice	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AAAAAGATTTACCTGGACAAA	0.318			NA											13	23					0	0	0.003163	0	0
IQCA1	79781	broad.mit.edu	37	2	237374189	237374189	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:237374189C>A	uc002vvz.1	-	6	1067	c.885G>T	c.(883-885)GAG>GAT	p.E295D	IQCA1_uc002vwb.2_Missense_Mutation_p.E302D|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.E295D	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	295							ATP binding			ovary(1)	1						CTTGAAGGTTCTCCTTGATAT	0.458			NA											48	58					1.83081e-24	2.45443e-24	0.00361	1	0
COL6A3	1293	broad.mit.edu	37	2	238266025	238266025	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:238266025C>T	uc002vwl.2	-	23	6832	c.6547G>A	c.(6547-6549)GGG>AGG	p.G2183R	COL6A3_uc002vwo.2_Missense_Mutation_p.G1977R|COL6A3_uc010znj.1_Missense_Mutation_p.G1576R|COL6A3_uc002vwp.1_5'Flank	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2183	Triple-helical region.|Collagen-like 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCTCTCCCTGGGACACCC	0.498			NA											253	235					0	0	0.00361	0	0
PDYN	5173	broad.mit.edu	37	20	1961233	1961233	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:1961233G>T	uc010gaj.2	-	3	743	c.501C>A	c.(499-501)GAC>GAA	p.D167E	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.D167E|PDYN_uc010zpt.1_Missense_Mutation_p.D12E	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	167					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCTCCTTGGGGTCCTCCTCAG	0.597			NA											40	105					4.57556e-38	6.67269e-38	0.013114	1	0
PRND	23627	broad.mit.edu	37	20	4705236	4705236	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:4705236C>G	uc002wkz.2	+	2	110	c.39C>G	c.(37-39)GTC>GTG	p.V13V		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	13					protein homooligomerization	anchored to membrane|plasma membrane					0						TGGCCACTGTCTGCATGCTGC	0.632			NA											9	132					0	0	0.010729	0	0
PRND	23627	broad.mit.edu	37	20	4705248	4705248	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:4705248C>G	uc002wkz.2	+	2	122	c.51C>G	c.(49-51)CTC>CTG	p.L17L		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	17					protein homooligomerization	anchored to membrane|plasma membrane					0						GCATGCTGCTCTTCAGCCACC	0.632			NA											8	128					0	0	0.008291	0	0
MKKS	8195	broad.mit.edu	37	20	10386212	10386212	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:10386212C>A	uc002wnt.1	-	6	2283	c.1396G>T	c.(1396-1398)GGT>TGT	p.G466C	MKKS_uc002wnu.1_Missense_Mutation_p.G466C|MKKS_uc010zrd.1_RNA	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	466					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						AGAATTTCACCTCCATCATGT	0.423	Melanoma(79;1979 2212 6640)		NA							Bardet-Biedl_syndrome				28	52					4.7796e-09	5.29866e-09	0.004656	1	0
C20orf26	26074	broad.mit.edu	37	20	20144808	20144808	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:20144808T>C	uc002wru.2	+	11	1217	c.1141T>C	c.(1141-1143)TAC>CAC	p.Y381H	C20orf26_uc010gcw.1_Missense_Mutation_p.Y335H|C20orf26_uc010zse.1_Missense_Mutation_p.Y381H|C20orf26_uc010zsf.1_Missense_Mutation_p.Y381H	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	381										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCGCCCCATCTACAGGGGAGC	0.507			NA											29	103					0	0	0.008361	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492565	21492565	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:21492565C>G	uc002wsi.2	-	2	1175	c.818G>C	c.(817-819)TGG>TCG	p.W273S		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	273					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						CGGCGCTCACCAAGTCCACTG	0.677			NA											22	77					0	0	0.002299	0	0
PLUNC	51297	broad.mit.edu	37	20	31825632	31825632	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:31825632G>T	uc002wyv.2	+	2	185	c.115G>T	c.(115-117)GCC>TCC	p.A39S	PLUNC_uc002wyt.3_Missense_Mutation_p.A39S|PLUNC_uc002wyu.3_Missense_Mutation_p.A39S	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	39					innate immune response	extracellular region	lipid binding				0						TGTGAATCCAGCCCTGCCCTT	0.468			NA											91	71					5.01286e-43	7.50015e-43	0.00361	1	0
AHCY	191	broad.mit.edu	37	20	32879309	32879309	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:32879309C>A	uc002xai.2	-	5	613	c.474G>T	c.(472-474)ACG>ACT	p.T158T	AHCY_uc002xaj.2_Silent_p.T130T	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	158	NAD.				methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0						GGACCCCAGTCGTGGTCTCCT	0.512			NA											94	98					1.63847e-34	2.35439e-34	0.00361	1	0
MYH7B	57644	broad.mit.edu	37	20	33578868	33578868	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:33578868C>A	uc002xbi.1	+	22	2345	c.2253C>A	c.(2251-2253)ATC>ATA	p.I751I		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	709	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGGAGGGGATCCGGATCTGCC	0.632			NA											73	86					8.07507e-42	1.20084e-41	0.00361	1	0
BPI	671	broad.mit.edu	37	20	36965553	36965553	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:36965553C>T	uc002xib.2	+	15	1493	c.1431C>T	c.(1429-1431)TTC>TTT	p.F477F		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	477					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				CCTAGAACTTCCTGCTGTTCG	0.542			NA											92	234					0	0	0.00361	0	0
PTPRT	11122	broad.mit.edu	37	20	40714455	40714455	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:40714455G>T	uc002xkg.2	-	28	4069	c.3885C>A	c.(3883-3885)TGC>TGA	p.C1295*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.C1314*|PTPRT_uc010ggi.2_Nonsense_Mutation_p.C498*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1295	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGCCCATAGCACCCGGAGG	0.542			NA											131	76					3.41043e-57	5.2304e-57	0.00361	1	0
PTPRT	11122	broad.mit.edu	37	20	40770587	40770587	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:40770587C>A	uc002xkg.2	-	18	2922	c.2738G>T	c.(2737-2739)CGC>CTC	p.R913L	PTPRT_uc010ggj.2_Missense_Mutation_p.R932L|PTPRT_uc010ggi.2_Missense_Mutation_p.R116L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	913	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATTCTTATTGCGGTTTTCATC	0.502			NA											86	388					2.61895e-37	3.7967e-37	0.00361	1	0
L3MBTL	26013	broad.mit.edu	37	20	42164887	42164887	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:42164887G>A	uc010zwh.1	+	18	2056	c.2010G>A	c.(2008-2010)AAG>AAA	p.K670K	L3MBTL_uc002xkl.2_Silent_p.K602K|L3MBTL_uc002xkm.2_Silent_p.K602K|L3MBTL_uc010ggl.2_Silent_p.K607K|L3MBTL_uc002xkn.1_Silent_p.K361K|L3MBTL_uc002xko.2_Silent_p.K254K	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	602					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCCGCAAGAAGAACCTCTCAG	0.637			NA											6	24					0	0	0.001168	0	0
ZNF334	55713	broad.mit.edu	37	20	45130263	45130263	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:45130263T>C	uc002xsc.2	-	5	1899	c.1715A>G	c.(1714-1716)TAT>TGT	p.Y572C	ZNF334_uc002xsa.2_Missense_Mutation_p.Y595C|ZNF334_uc002xsb.2_Missense_Mutation_p.Y534C|ZNF334_uc002xsd.2_Missense_Mutation_p.Y534C|ZNF334_uc010ghl.2_Missense_Mutation_p.Y571C	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	572	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				ATTACACTCATAGGGTCTCTG	0.443			NA											124	123					0	0	0.00361	0	0
PREX1	57580	broad.mit.edu	37	20	47351100	47351100	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:47351100C>A	uc002xtw.1	-	4	525	c.502G>T	c.(502-504)GTG>TTG	p.V168L		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	168	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AAGGCGCGCACGGTAGGGATC	0.557			NA											127	161					2.27795e-59	3.49904e-59	0.00361	1	0
SNAI1	6615	broad.mit.edu	37	20	48600685	48600685	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:48600685C>T	uc002xuz.2	+	2	477	c.407C>T	c.(406-408)CCC>CTC	p.P136L		NM_005985	NP_005976	O95863	SNAI1_HUMAN	snail 1 homolog	136	Required for FBXL14-triggered degradation.				epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			GGCCAAGTGCCCAAGCAGCTG	0.602			NA											34	134					0	0	0.002836	0	0
FAM65C	140876	broad.mit.edu	37	20	49225195	49225195	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:49225195C>G	uc002xvm.2	-	10	1071	c.753G>C	c.(751-753)GAG>GAC	p.E251D	FAM65C_uc010zyt.1_Missense_Mutation_p.E255D|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.E251D	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	251										ovary(2)	2						AGGCCTTCTCCTCTTCGTCCC	0.642			NA											60	231					0	0	0.00361	0	0
NFATC2	4773	broad.mit.edu	37	20	50007939	50007939	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:50007939C>A	uc002xwd.2	-	10	2992	c.2772G>T	c.(2770-2772)CAG>CAT	p.Q924H	NFATC2_uc002xwc.2_3'UTR|NFATC2_uc010zyv.1_3'UTR|NFATC2_uc010zyw.1_Missense_Mutation_p.Q705H|NFATC2_uc010zyx.1_3'UTR|NFATC2_uc010zyy.1_3'UTR|NFATC2_uc010zyz.1_Missense_Mutation_p.Q705H|NFATC2_uc002xwe.2_Missense_Mutation_p.Q904H	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	924					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TCTTTTACGTCTGATTTCTGG	0.493			NA											32	200					2.20262e-25	2.97734e-25	0.002836	1	0
TSHZ2	128553	broad.mit.edu	37	20	51870957	51870957	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:51870957T>A	uc002xwo.2	+	2	1916	c.960T>A	c.(958-960)GCT>GCA	p.A320A		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	320					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TCACCCCGGCTAAGAAACGCG	0.448			NA											46	185					0	0	0.00361	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872151	51872151	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:51872151C>A	uc002xwo.2	+	2	3110	c.2154C>A	c.(2152-2154)TGC>TGA	p.C718*		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	718					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CACCTTCCTGCTCCAGCCCAA	0.582			NA											86	65					9.11151e-29	1.26477e-28	0.00361	1	0
PCK1	5105	broad.mit.edu	37	20	56139383	56139383	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:56139383G>T	uc002xyn.3	+	7	1283	c.1120G>T	c.(1120-1122)GAT>TAT	p.D374Y	PCK1_uc010zzm.1_Missense_Mutation_p.D57Y	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	374					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGAAGGCATTGATGAGCCGCT	0.557			NA											67	53					6.75472e-32	9.52464e-32	0.00361	1	0
ZNF831	128611	broad.mit.edu	37	20	57767170	57767170	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:57767170C>T	uc002yan.2	+	1	1096	c.1096C>T	c.(1096-1098)CTT>TTT	p.L366F		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	366						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCTGCACAGCCTTTCGGAGCA	0.532			NA											20	33					0	0	0.008871	0	0
OGFR	11054	broad.mit.edu	37	20	61444777	61444777	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:61444777C>T	uc002ydj.2	+	7	1845	c.1810C>T	c.(1810-1812)CCC>TCC	p.P604S	OGFR_uc002ydk.2_Missense_Mutation_p.P587S|OGFR_uc002ydl.2_Missense_Mutation_p.P552S|uc011aam.1_Intron	NM_007346	NP_031372	Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	604	5.|7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity				0	Breast(26;3.65e-08)					GACCCCAGGCCCCCGCCCGGC	0.741			NA											9	15					0	0	0.008291	0	0
BIRC7	79444	broad.mit.edu	37	20	61869809	61869809	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:61869809T>A	uc002yej.2	+	3	684	c.511T>A	c.(511-513)TCC>ACC	p.S171T	BIRC7_uc010gkc.1_Missense_Mutation_p.S171T|BIRC7_uc002yei.2_Missense_Mutation_p.S171T|hsa-mir-3196|MI0014241_5'Flank	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	171					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					GGAGACTCACTCCCAGCTGCT	0.622			NA											30	50					0	0	0.008361	0	0
GMEB2	26205	broad.mit.edu	37	20	62221554	62221554	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:62221554G>A	uc002yfp.1	-	9	1960	c.1481C>T	c.(1480-1482)TCG>TTG	p.S494L	GMEB2_uc002yfo.1_Missense_Mutation_p.S416L|GMEB2_uc002yfq.1_Missense_Mutation_p.S494L	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	494					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			GGAGCCAGGCGAGGCCTGGGC	0.682			NA											16	68					0	0	0.003163	0	0
TPTE	7179	broad.mit.edu	37	21	10907001	10907001	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:10907001T>A	uc002yip.1	-	24	1928	c.1560A>T	c.(1558-1560)AAA>AAT	p.K520N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.K502N|TPTE_uc002yir.1_Missense_Mutation_p.K482N|TPTE_uc010gkv.1_Missense_Mutation_p.K382N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	520	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGCTTTTTGTTTATGTAGAT	0.343			NA											13	124					0	0	0.001855	0	0
TPTE	7179	broad.mit.edu	37	21	10933891	10933891	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:10933891G>T	uc002yip.1	-	17	1356	c.988C>A	c.(988-990)CTT>ATT	p.L330I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.L312I|TPTE_uc002yir.1_Missense_Mutation_p.L292I|TPTE_uc010gkv.1_Missense_Mutation_p.L192I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	330	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGTTTTCAAGATCTTGAGCC	0.318			NA											71	494					2.60632e-51	3.95385e-51	0.00361	1	0
TPTE	7179	broad.mit.edu	37	21	10934045	10934045	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:10934045G>T	uc002yip.1	-	16	1300	c.932C>A	c.(931-933)ACT>AAT	p.T311N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.T293N|TPTE_uc002yir.1_Missense_Mutation_p.T273N|TPTE_uc010gkv.1_Missense_Mutation_p.T173N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	311	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTACTGTAGAGTGGGGACATT	0.299			NA											56	405					1.22119e-34	1.75737e-34	0.00361	1	0
LIPI	149998	broad.mit.edu	37	21	15554145	15554145	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:15554145G>A	uc002yjm.2	-	4	650	c.640C>T	c.(640-642)CCA>TCA	p.P214S	LIPI_uc010gkw.1_Missense_Mutation_p.P147S	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	193					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		CTATATGGTGGTTTTCTGGAG	0.403			NA											6	82					0	0	0.004482	0	0
CXADR	1525	broad.mit.edu	37	21	18937929	18937929	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:18937929G>T	uc002yki.2	+	7	1135	c.1017G>T	c.(1015-1017)AAG>AAT	p.K339N	CXADR_uc002ykh.1_3'UTR|CXADR_uc010gld.1_3'UTR|CXADR_uc010gle.1_3'UTR|CXADR_uc002ykj.1_Missense_Mutation_p.K312N	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	339	Cytoplasmic (Potential).				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		CACCTGCTAAGGTAGCTGCCC	0.478			NA											20	152					8.34094e-07	9.01226e-07	0.008871	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19666671	19666671	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:19666671C>T	uc002ykw.2	-	21	2433	c.2402G>A	c.(2401-2403)GGT>GAT	p.G801D		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	801	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ATAATACAGACCCACAACCCA	0.532			NA											32	254					0	0	0.003755	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28214825	28214825	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:28214825G>T	uc002ymf.2	-	2	1365	c.910C>A	c.(910-912)CTG>ATG	p.L304M		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	304	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		ACCACCACCAGGCTAACTGAA	0.512			NA											86	41					7.83748e-43	1.17084e-42	0.00361	1	0
KRTAP13-3	337960	broad.mit.edu	37	21	31797877	31797877	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:31797877G>A	uc002yob.1	-	1	354	c.354C>T	c.(352-354)TCC>TCT	p.S118S		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	118						intermediate filament				ovary(1)|lung(1)	2						AGCCCAGTGAGGAGCAGCTCC	0.488			NA											36	19					0	0	0.004878	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933555	31933555	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:31933555G>T	uc011adb.1	-	1	54	c.54C>A	c.(52-54)TTC>TTA	p.F18L		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	18						intermediate filament					0						CCAGGCCACCGAATCCTCCAC	0.557			NA											25	187					1.10923e-09	1.24519e-09	0.00278	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253354	32253354	+	Nonstop_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:32253354A>T	uc002yov.2	-	1	521	c.490T>A	c.(490-492)TAA>AAA	p.*164K		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	164						keratin filament	structural molecule activity			pancreas(1)	1						CTACACACTTAGCAGGTTCTT	0.567			NA											28	179					0	0	0.00632	0	0
DOPEY2	9980	broad.mit.edu	37	21	37618415	37618415	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:37618415G>A	uc002yvg.2	+	19	4216	c.4137G>A	c.(4135-4137)CAG>CAA	p.Q1379Q	DOPEY2_uc011aeb.1_Silent_p.Q1328Q|DOPEY2_uc002yvh.2_Silent_p.Q230Q	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1379					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GCTTGCTGCAGAGGTGCAAAG	0.572			NA											6	138					0	0	0.001984	0	0
SIM2	6493	broad.mit.edu	37	21	38115717	38115717	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:38115717C>A	uc002yvr.2	+	9	1084	c.1028C>A	c.(1027-1029)TCC>TAC	p.S343Y	SIM2_uc002yvq.2_Missense_Mutation_p.S343Y	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	343	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						CTTCAGCTGTCCCTGGAGCAG	0.567			NA											35	207					3.76114e-14	4.46777e-14	0.004289	1	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959964	45959964	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:45959964C>G	uc002zfh.1	-	1	115	c.70G>C	c.(70-72)GAG>CAG	p.E24Q	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	24						keratin filament				skin(1)	1						CAGCAGCTCTCTGGGCAGGCA	0.706			NA											124	76					0	0	0.00361	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45970704	45970704	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:45970704G>C	uc002zfi.1	-	1	685	c.638C>G	c.(637-639)TCT>TGT	p.S213C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	213	20.|22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1						CTGGCAGCTAGACTGCTGGCA	0.642			NA											46	333					0	0	0.00361	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45970938	45970938	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:45970938G>T	uc002zfi.1	-	1	451	c.404C>A	c.(403-405)TCC>TAC	p.S135Y	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	135	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1						CTGCTGGCAGGAGGAAGAGGC	0.617			NA											11	313					1.58986e-06	1.70841e-06	0.008291	1	0
COL6A1	1291	broad.mit.edu	37	21	47421172	47421172	+	Nonsense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr21:47421172A>T	uc002zhu.1	+	30	1930	c.1828A>T	c.(1828-1830)AAG>TAG	p.K610*	COL6A1_uc010gqd.1_5'UTR|COL6A1_uc002zhv.1_5'UTR|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	610	C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TGCAGAATGCAAGTGCGGCCC	0.647			NA											117	65					0	0	0.00361	0	0
POTEH	23784	broad.mit.edu	37	22	16287306	16287306	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:16287306G>T	uc010gqp.2	-	1	632	c.580C>A	c.(580-582)CTC>ATC	p.L194I	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_Missense_Mutation_p.L29I	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	194	ANK 1.									skin(1)	1						ATGACGATGAGATCCTTTCTG	0.562			NA											57	276					1.12115e-39	1.64235e-39	0.00361	1	0
GNAZ	2781	broad.mit.edu	37	22	23438506	23438506	+	Silent	SNP	G	G	A	rs34937804	byFrequency	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:23438506G>A	uc002zwu.1	+	2	1161	c.624G>A	c.(622-624)GAG>GAA	p.E208E	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	208						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		AGAGGTCAGAGCGCAAAAAGT	0.567			NA											174	86					0	0	0.00361	0	0
SMTN	6525	broad.mit.edu	37	22	31493257	31493257	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:31493257G>T	uc003ajl.1	+	16	2310	c.2092G>T	c.(2092-2094)GGC>TGC	p.G698C	SMTN_uc003ajk.1_Missense_Mutation_p.G698C|SMTN_uc003ajm.1_Missense_Mutation_p.G698C|SMTN_uc011ale.1_Missense_Mutation_p.G783C|SMTN_uc011alf.1_Missense_Mutation_p.G754C|SMTN_uc003ajn.1_Missense_Mutation_p.G721C|SMTN_uc011alg.1_Missense_Mutation_p.G154C|SMTN_uc003ajo.1_Missense_Mutation_p.G221C|SMTN_uc010gwe.1_Missense_Mutation_p.G78C	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	698					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						TTTTGCAGATGGCAGTGGCAG	0.582			NA											75	68					6.30617e-38	9.18283e-38	0.00361	1	0
TRIOBP	11078	broad.mit.edu	37	22	38119801	38119801	+	Missense_Mutation	SNP	A	A	G	rs71317064		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:38119801A>G	uc003atr.2	+	7	1509	c.1238A>G	c.(1237-1239)AAA>AGA	p.K413R	TRIOBP_uc003atu.2_Missense_Mutation_p.K241R|TRIOBP_uc003atq.1_Missense_Mutation_p.K413R|TRIOBP_uc003ats.1_Missense_Mutation_p.K241R	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	413					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GACAATCCCAAAGCCTCCAGA	0.582			NA											4	140					0	0	0.009096	0	0
APOBEC3H	164668	broad.mit.edu	37	22	39497382	39497382	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:39497382G>C	uc011aoh.1	+	3	357	c.291G>C	c.(289-291)AAG>AAC	p.K97N	APOBEC3H_uc011aoi.1_5'Flank|APOBEC3H_uc003axa.3_5'Flank	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	97					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					ACTTCATCAAGGCTCACGACC	0.602			NA											19	83					0	0	0.008871	0	0
CPT1B	1375	broad.mit.edu	37	22	51014701	51014701	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr22:51014701T>C	uc003bmk.3	-	5	787	c.625A>G	c.(625-627)AAA>GAA	p.K209E	CPT1B_uc003bml.2_Missense_Mutation_p.K209E|CPT1B_uc003bmm.2_Missense_Mutation_p.K209E|CPT1B_uc003bmo.2_Missense_Mutation_p.K209E|CPT1B_uc011asa.1_Missense_Mutation_p.K175E|CPT1B_uc003bmn.2_Missense_Mutation_p.K209E|CPT1B_uc011asb.1_Missense_Mutation_p.K209E|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.K6E	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	209	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		TGGAATTCTTTGGCCAGCAAC	0.537	Esophageal Squamous(170;988 1933 25577 30295 48163)		NA									OREG0026685	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	75					0	0	0.00623	0	0
UBE2E2	7325	broad.mit.edu	37	3	23250330	23250330	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:23250330G>T	uc003ccg.2	+	2	320	c.140G>T	c.(139-141)AGC>ATC	p.S47I	UBE2E2_uc010hfc.2_RNA	NM_152653	NP_689866	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	47					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity				0						AAAATATCCAGCAAAACCGCT	0.363	GBM(85;1941 2083 9456)		NA											10	31					5.50884e-06	5.83639e-06	0.001368	1	0
SCN11A	11280	broad.mit.edu	37	3	38888582	38888582	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:38888582G>A	uc011ays.1	-	26	5178	c.4979C>T	c.(4978-4980)GCA>GTA	p.A1660V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1660					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATTTGGCTTTGCGACACGCAA	0.438			NA											48	86					0	0	0.00361	0	0
SLC25A38	54977	broad.mit.edu	37	3	39432974	39432974	+	Missense_Mutation	SNP	A	A	C	rs150252435		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:39432974A>C	uc003cjo.2	+	4	720	c.319A>C	c.(319-321)ACT>CCT	p.T107P		NM_017875	NP_060345	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	107	Solcar 1.|Helical; Name=2; (Potential).				erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTACTTTGGCACTCTCTACTC	0.498			NA											171	427					0	0	0.00361	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266166	41266166	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:41266166G>A	uc010hia.1	+	4	319	c.163G>A	c.(163-165)GAG>AAG	p.E55K	CTNNB1_uc003ckp.2_Missense_Mutation_p.E55K|CTNNB1_uc003ckq.2_Missense_Mutation_p.E55K|CTNNB1_uc003ckr.2_Missense_Mutation_p.E55K|CTNNB1_uc011azf.1_Missense_Mutation_p.E48K|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	55					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_A80del(63)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.E55K(3)|p.T3_A126del(2)|p.V22_L139>V(2)|p.M5_N141>D(2)|p.?(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A20_Q143del(1)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.A5_Q72del(1)|p.A5_G80>(1)|p.Q28_Q61del(1)|p.M1_A87del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.E55G(1)|p.V22_G80>NNNNN(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.S45_D58del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.D6_K133del(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.A5_R90del(1)|p.W25_A80del(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.A5_D144>D(1)|p.A20_R151del(1)|p.L7_I140del(1)|p.A21_A80del(1)|p.E9_A80del(1)|p.K19_Y142>V(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.V22_A80del(1)|p.M8_A80del(1)|p.E9_I140del(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.D6_I140del(1)|p.S23_I140del(1)|p.A20_L148del(1)|p.Q28_I140del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TCCTGAGGAAGAGGATGTGGA	0.463	Colon(6;3 56 14213 18255)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				20	55					0	0	0.010504	0	0
SETD2	29072	broad.mit.edu	37	3	47162371	47162371	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:47162371G>C	uc003cqs.2	-	3	3808	c.3755C>G	c.(3754-3756)TCA>TGA	p.S1252*	SETD2_uc003cqv.2_Nonsense_Mutation_p.S1241*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GAGCTCTTCTGATGAGTGCAA	0.453			NA	N|F|S|Mis		clear cell renal carcinoma								32	119					0	0	0.012213	0	0
MAP4	4134	broad.mit.edu	37	3	47956430	47956430	+	Splice_Site	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:47956430C>G	uc003csb.2	-	8	2403	c.1877_splice	c.e8-1	p.E626_splice	MAP4_uc003csc.3_Splice_Site_p.E626_splice|MAP4_uc011bbf.1_Splice_Site_p.E603_splice|MAP4_uc003csf.3_Splice_Site_p.E643_splice	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1						negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GTGACGGTTTCTAAAGGTAAT	0.413			NA											45	139					0	0	0.00361	0	0
CELSR3	1951	broad.mit.edu	37	3	48699679	48699679	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:48699679C>G	uc003cul.2	-	1	670	c.389G>C	c.(388-390)GGG>GCG	p.G130A	CELSR3_uc003cuf.1_Missense_Mutation_p.G200A	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	130	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TAACACAGACCCTGGTCCCTG	0.622			NA											72	174					0	0	0.00361	0	0
USP19	10869	broad.mit.edu	37	3	49152706	49152706	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:49152706C>A	uc003cwd.1	-	12	1829	c.1668G>T	c.(1666-1668)GCG>GCT	p.A556A	USP19_uc003cwa.2_Silent_p.A364A|USP19_uc003cvz.3_Silent_p.A659A|USP19_uc011bcg.1_Silent_p.A647A|USP19_uc003cwb.2_Silent_p.A642A|USP19_uc003cwc.1_Silent_p.A314A|USP19_uc011bch.1_Silent_p.A657A	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	556	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCTTCCACAGCGCCCGAAGCA	0.602			NA											16	48					2.32078e-09	2.59631e-09	0.003163	1	0
RNF123	63891	broad.mit.edu	37	3	49753568	49753568	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:49753568G>C	uc003cxh.2	+	34	3459	c.3373G>C	c.(3373-3375)GAG>CAG	p.E1125Q	RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1125						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GGTGACAGCTGAGAGGAACCT	0.602			NA											9	24					0	0	0.006214	0	0
DOCK3	1795	broad.mit.edu	37	3	51418789	51418789	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:51418789T>C	uc011bds.1	+	53	5915	c.5892T>C	c.(5890-5892)CCT>CCC	p.P1964P		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1964						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCGTCATCCCTCAGGACCCCA	0.677			NA											3	72					0	0	0.004672	0	0
STAB1	23166	broad.mit.edu	37	3	52557671	52557671	+	Missense_Mutation	SNP	C	C	A	rs147205277		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:52557671C>A	uc003dej.2	+	66	7368	c.7294C>A	c.(7294-7296)CCA>ACA	p.P2432T	STAB1_uc003del.2_Missense_Mutation_p.P344T	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2432	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCTGCAGGCCCCAGGGACAGT	0.632			NA											20	55					5.35267e-07	5.82199e-07	0.007413	1	0
TMEM110	375346	broad.mit.edu	37	3	52886638	52886638	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:52886638C>T	uc003dge.2	-	3	367	c.286G>A	c.(286-288)GAA>AAA	p.E96K	TMEM110_uc003dgc.3_Missense_Mutation_p.E96K	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	96						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		GGGTCCTCTTCAGTGAGATCT	0.443			NA											9	218					0	0	0.010729	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432844	73432844	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:73432844G>T	uc003dpl.1	-	10	2969	c.2873C>A	c.(2872-2874)ACC>AAC	p.T958N	PDZRN3_uc011bgh.1_Missense_Mutation_p.T615N|PDZRN3_uc010hoe.1_Missense_Mutation_p.T656N|PDZRN3_uc011bgf.1_Missense_Mutation_p.T675N|PDZRN3_uc011bgg.1_Missense_Mutation_p.T678N	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	958							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTCGTCGGTGGTCATGCCGCT	0.682			NA											28	63					4.87955e-14	5.7823e-14	0.005443	1	0
CADM2	253559	broad.mit.edu	37	3	86028411	86028411	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:86028411T>A	uc003dqj.2	+	8	1667	c.1041T>A	c.(1039-1041)TCT>TCA	p.S347S	CADM2_uc003dqk.2_Intron|CADM2_uc003dql.2_Silent_p.S349S	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	347	Thr-rich.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CAACCACATCTGCAACAACCA	0.443			NA											91	192					0	0	0.00361	0	0
VGLL3	389136	broad.mit.edu	37	3	87017950	87017950	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:87017950G>C	uc003dqn.2	-	3	1091	c.727C>G	c.(727-729)CAT>GAT	p.H243D		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	243	His-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		tggtgatgatggtggcggtgg	0.478			NA											27	49					0	0	0.003954	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568743	99568743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:99568743G>A	uc003dtm.2	-	5	2240	c.1777C>T	c.(1777-1779)CAA>TAA	p.Q593*	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Nonsense_Mutation_p.Q593*|FILIP1L_uc010hpf.2_Nonsense_Mutation_p.Q169*|FILIP1L_uc010hpg.2_Nonsense_Mutation_p.Q353*|FILIP1L_uc003dtn.2_Nonsense_Mutation_p.Q353*|FILIP1L_uc003dtp.1_Nonsense_Mutation_p.Q353*	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	593	Potential.					cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						TCCAATGATTGAAGCCTATTT	0.323			NA											4	156					0	0	0.009096	0	0
TOMM70A	9868	broad.mit.edu	37	3	100105689	100105689	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:100105689G>C	uc003dtw.2	-	2	890	c.458C>G	c.(457-459)TCT>TGT	p.S153C		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	153	Cytoplasmic (Potential).|TPR 2.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						ATAAAATGTAGAAAGGTCAAC	0.348			NA											4	78					0	0	0.009096	0	0
ABI3BP	25890	broad.mit.edu	37	3	100511545	100511545	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:100511545C>G	uc003dun.2	-	23	2041	c.1956G>C	c.(1954-1956)AAG>AAC	p.K652N	ABI3BP_uc003duj.2_Missense_Mutation_p.K207N|ABI3BP_uc003duk.2_Missense_Mutation_p.K336N|ABI3BP_uc003dul.2_Missense_Mutation_p.K457N|ABI3BP_uc011bhd.1_Missense_Mutation_p.K606N|ABI3BP_uc003dum.2_Missense_Mutation_p.K38N	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	652	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						CCTGAGTTGTCTTTGCTAGTT	0.368			NA											5	75					0	0	0.000602	0	0
ZPLD1	131368	broad.mit.edu	37	3	102196379	102196379	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:102196379C>T	uc003dvs.1	+	18	2047	c.1165C>T	c.(1165-1167)CTT>TTT	p.L389F	ZPLD1_uc003dvt.1_Missense_Mutation_p.L405F|ZPLD1_uc011bhg.1_Missense_Mutation_p.L389F	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	389	Helical; (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						CTTTTCTCTTCTTCTGTGCTC	0.483			NA											141	184					0	0	0.00361	0	0
DZIP3	9666	broad.mit.edu	37	3	108353773	108353773	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:108353773G>T	uc003dxd.2	+	10	1294	c.872G>T	c.(871-873)TGC>TTC	p.C291F	DZIP3_uc003dxf.1_Missense_Mutation_p.C291F|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.C291F|DZIP3_uc003dxg.1_Missense_Mutation_p.C14F	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	291					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CATAAAATTTGCTGGAAAAAG	0.264			NA											34	90					5.71845e-15	6.88462e-15	0.005524	1	0
GAP43	2596	broad.mit.edu	37	3	115395427	115395428	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:115395427_115395428GG>TC	uc003ebq.2	+	2	984_985	c.598_599GG>TC	c.(598-600)GGG>TCG	p.G200S	GAP43_uc003ebr.2_Missense_Mutation_p.G236S	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	200					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		AACGGAGACTGGGGAGAGCAGC	0.426			NA											6	28					0	0	0.004672	0	0
STXBP5L	9515	broad.mit.edu	37	3	120764291	120764291	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:120764291G>A	uc003eec.3	+	5	519	c.379G>A	c.(379-381)GTC>ATC	p.V127I	STXBP5L_uc011bji.1_Missense_Mutation_p.V127I	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	127	WD 2.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GGGTGCCTTGGTCAGTGCAAG	0.353			NA											12	272					0	0	0.004007	0	0
CASR	846	broad.mit.edu	37	3	122002903	122002903	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:122002903G>T	uc003eev.3	+	7	2474	c.2102G>T	c.(2101-2103)CGT>CTT	p.R701L	CASR_uc003eew.3_Missense_Mutation_p.R711L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	701	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AAAACCAACCGTGTCCTCCTG	0.602			NA											25	73					5.45024e-15	6.56978e-15	0.00333	1	0
UMPS	7372	broad.mit.edu	37	3	124456947	124456947	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:124456947G>C	uc003ehl.3	+	3	949	c.843G>C	c.(841-843)AAG>AAC	p.K281N	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Missense_Mutation_p.K103N|UMPS_uc011bkb.1_Missense_Mutation_p.K189N|UMPS_uc011bkc.1_Missense_Mutation_p.K103N|UMPS_uc003ehn.3_Missense_Mutation_p.K103N|UMPS_uc011bkd.1_Missense_Mutation_p.K103N	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	281	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		GCATGCTGAAGACTCATGTAG	0.413			NA											28	83					0	0	0.005443	0	0
CCDC37	348807	broad.mit.edu	37	3	126132992	126132992	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:126132992C>G	uc003eiu.1	+	4	294	c.195C>G	c.(193-195)CTC>CTG	p.L65L	CCDC37_uc010hsg.1_Silent_p.L65L	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	65										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		TCTTCTTGCTCAGAGATCAGG	0.567			NA											16	398					0	0	0.006122	0	0
CCDC37	348807	broad.mit.edu	37	3	126133017	126133017	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:126133017C>G	uc003eiu.1	+	4	319	c.220C>G	c.(220-222)CTC>GTC	p.L74V	CCDC37_uc010hsg.1_Missense_Mutation_p.L74V	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	74										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		GAATAAGGCTCTCTCCGTGAG	0.552			NA											57	236					0	0	0.00361	0	0
Unknown	0	broad.mit.edu	37	3	129137199	129137199	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:129137199G>A	uc003emg.2	-	3	742	c.579C>T	c.(577-579)TAC>TAT	p.Y193Y		NM_207307	NP_997190			hypothetical protein LOC90288												NA						GGCTATGCAGGTAGGAGTACA	0.597			NA											11	29					0	0	0.008291	0	0
TRH	7200	broad.mit.edu	37	3	129695884	129695884	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:129695884G>A	uc003enc.2	+	3	1115	c.554G>A	c.(553-555)CGC>CAC	p.R185H		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	185					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						CCTGAAAAACGCCAGCATCCG	0.532	Esophageal Squamous(60;321 1330 17401 41911)		NA											33	53					0	0	0.003755	0	0
IGSF10	285313	broad.mit.edu	37	3	151163029	151163029	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:151163029G>A	uc011bod.1	-	4	4740	c.4740C>T	c.(4738-4740)TAC>TAT	p.Y1580Y		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1580					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAATTTCTGAGTATGGTTTGT	0.433			NA											10	214					0	0	0.006214	0	0
PLCH1	23007	broad.mit.edu	37	3	155303979	155303979	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:155303979C>A	uc011bok.1	-	4	716	c.439G>T	c.(439-441)GTG>TTG	p.V147L	PLCH1_uc011boj.1_Missense_Mutation_p.V147L|PLCH1_uc011bol.1_Missense_Mutation_p.V129L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	147	EF-hand 1.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTCTGCTTCACCCATGTGCAG	0.408			NA											51	76					2.76378e-25	3.72048e-25	0.00361	1	0
SHOX2	6474	broad.mit.edu	37	3	157820646	157820646	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:157820646C>A	uc003fbr.2	-	2	515	c.376G>T	c.(376-378)GAT>TAT	p.D126Y	SHOX2_uc003fbs.2_Missense_Mutation_p.D150Y|SHOX2_uc010hvw.2_Missense_Mutation_p.D126Y	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	126					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CCTTTCGCATCCTCTTTGCGA	0.483			NA											42	115					7.05121e-23	9.30039e-23	0.010771	1	0
SI	6476	broad.mit.edu	37	3	164757711	164757711	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:164757711C>T	uc003fei.2	-	19	2270	c.2208G>A	c.(2206-2208)TGG>TGA	p.W736*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	736	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATGCAGGGCCCCACAAAAACT	0.338			NA								HNSCC(35;0.089)			4	218					0	0	0.001168	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	Colon(199;1504 1750 3362 26421 31210 32040)	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	98					0	0	0.000602	0	0
CCDC39	339829	broad.mit.edu	37	3	180364997	180364997	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:180364997G>A	uc010hxe.2	-	11	1512	c.1397C>T	c.(1396-1398)TCA>TTA	p.S466L	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	466	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTTTAACCGTGACATTCTCCG	0.318			NA											7	44					0	0	0.001984	0	0
DGKG	1608	broad.mit.edu	37	3	186038239	186038239	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:186038239C>T	uc003fqa.2	-	2	547	c.10G>A	c.(10-12)GAA>AAA	p.E4K	DGKG_uc003fqb.2_Missense_Mutation_p.E4K|DGKG_uc003fqc.2_Missense_Mutation_p.E4K|DGKG_uc011brx.1_Missense_Mutation_p.E4K	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	4					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	ACCCACCGTTCTTCACCCATT	0.483			NA											14	100					0	0	0.004007	0	0
RFC4	5984	broad.mit.edu	37	3	186508170	186508170	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:186508170C>A	uc003fqz.2	-	9	1050	c.827G>T	c.(826-828)GGA>GTA	p.G276V	RFC4_uc011bsc.1_Missense_Mutation_p.G276V	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	276					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		AGCAAATACTCCATCAATTTT	0.418			NA											30	63					5.60225e-13	6.56723e-13	0.009535	1	0
OSTN	344901	broad.mit.edu	37	3	190936629	190936629	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:190936629G>A	uc011bsn.1	+	2	196	c.196G>A	c.(196-198)GAT>AAT	p.D66N		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	66					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		CTTGCTTCTTGATGAATTGGT	0.453			NA											42	53					0	0	0.00623	0	0
TNK2	10188	broad.mit.edu	37	3	195595457	195595457	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:195595457G>A	uc003fvu.1	-	12	2210	c.1667C>T	c.(1666-1668)CCG>CTG	p.P556L	TNK2_uc003fvq.1_5'UTR|TNK2_uc003fvr.1_Missense_Mutation_p.P81L|TNK2_uc003fvs.1_Missense_Mutation_p.P588L|TNK2_uc003fvt.1_Missense_Mutation_p.P634L|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	556				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CTTGGTGCCCGGCACCCGCGC	0.726			NA											4	26					0	0	0.009096	0	0
SLC26A1	10861	broad.mit.edu	37	4	984068	984068	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:984068G>T	uc003gcb.2	-	4	1037	c.659C>A	c.(658-660)TCC>TAC	p.S220Y	SLC26A1_uc003gbx.2_Intron|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Missense_Mutation_p.S220Y	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	220						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GATGGTCACGGAGGCCCCCAT	0.672			NA											16	17					1.15088e-07	1.25737e-07	0.004007	1	0
CRIPAK	285464	broad.mit.edu	37	4	1389250	1389251	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:1389250_1389251GG>TT	uc003gdf.2	+	1	3911_3912	c.951_952GG>TT	c.(949-954)ATGGAG>ATTTAG	p.317_318ME>I*		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	317_318					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GTGCCCATATGGAGTGCCCGCC	0.663			NA											254	346					0	0	0.004672	0	0
POLN	353497	broad.mit.edu	37	4	2130952	2130952	+	Silent	SNP	C	C	A	rs141684891	byFrequency	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:2130952C>A	uc003ger.2	-	16	1821	c.1821G>T	c.(1819-1821)CCG>CCT	p.P607P	POLN_uc010icg.1_Silent_p.P55P|POLN_uc010ich.1_Silent_p.P139P	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	607					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			ACATGGCCCTCGGGGAGATCG	0.403			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					45	55					8.72198e-27	1.19213e-26	0.00361	1	0
EVC2	132884	broad.mit.edu	37	4	5633709	5633709	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:5633709C>A	uc003gij.2	-	11	1575	c.1521G>T	c.(1519-1521)CAG>CAT	p.Q507H	EVC2_uc011bwb.1_Translation_Start_Site|EVC2_uc003gik.2_Missense_Mutation_p.Q427H	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	507	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TCAAGTGCTCCTGTTCCAGGC	0.488			NA											31	81					6.38683e-12	7.42479e-12	0.008361	1	0
KIAA0232	9778	broad.mit.edu	37	4	6865424	6865424	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:6865424G>T	uc003gjr.3	+	7	3778	c.3315G>T	c.(3313-3315)CGG>CGT	p.R1105R	KIAA0232_uc003gjq.3_Silent_p.R1105R	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	1105							ATP binding			ovary(2)	2						TCTCTCCTCGGACTCACTTTC	0.458			NA											50	79					1.81118e-26	2.4618e-26	0.00361	1	0
SORCS2	57537	broad.mit.edu	37	4	7728547	7728547	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:7728547C>T	uc003gkb.3	+	21	2786	c.2786C>T	c.(2785-2787)TCG>TTG	p.S929L	SORCS2_uc011bwi.1_Missense_Mutation_p.S757L	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	929	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						ACGCGGTTTTCGGACACGGGC	0.662			NA											7	223					0	0	0.001984	0	0
CPZ	8532	broad.mit.edu	37	4	8603114	8603114	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:8603114G>C	uc003glm.2	+	3	512	c.386G>C	c.(385-387)TGC>TCC	p.C129S	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Missense_Mutation_p.C118S|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	129	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						CGGGAGGTCTGCCAGCCCGCC	0.687			NA											6	14					0	0	0.001168	0	0
BOD1L	259282	broad.mit.edu	37	4	13606479	13606479	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:13606479C>G	uc003gmz.1	-	10	2162	c.2045G>C	c.(2044-2046)CGC>CCC	p.R682P	BOD1L_uc010idr.1_Missense_Mutation_p.R19P	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	682	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						AATTTCTGAGCGTTCTACTTG	0.398			NA											218	399					0	0	0.00361	0	0
SLIT2	9353	broad.mit.edu	37	4	20530608	20530608	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:20530608G>C	uc003gpr.1	+	16	1703	c.1499G>C	c.(1498-1500)TGC>TCC	p.C500S	SLIT2_uc003gps.1_Missense_Mutation_p.C492S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	500	LRRNT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGTGGAGACTGCTTTGCGGAT	0.388			NA											56	113					0	0	0.00361	0	0
PCDH7	5099	broad.mit.edu	37	4	30724649	30724649	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:30724649C>A	uc003gsk.1	+	1	2613	c.1605C>A	c.(1603-1605)TTC>TTA	p.F535L	PCDH7_uc011bxw.1_Missense_Mutation_p.F488L|PCDH7_uc011bxx.1_Missense_Mutation_p.F535L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	535	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CGCCCATGTTCGGCCAGTCGG	0.622			NA											7	63					0.000442599	0.000458023	0.006214	1	0
PCDH7	5099	broad.mit.edu	37	4	31144127	31144127	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:31144127G>T	uc011bxx.1	+	3	4408	c.3400G>T	c.(3400-3402)GGG>TGG	p.G1134W	PCDH7_uc011bxw.1_Missense_Mutation_p.G1087W	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AGCCCTGACTGGGAAGTGCAC	0.507			NA											75	123					6.20995e-33	8.80717e-33	0.00361	1	0
GABRG1	2565	broad.mit.edu	37	4	46125841	46125841	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:46125841C>G	uc003gxb.2	-	1	242	c.90G>C	c.(88-90)CTG>CTC	p.L30L		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	30					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTCCCAAATGCAGGGTCAGTA	0.418			NA											38	62					0	0	0.00623	0	0
ATP10D	57205	broad.mit.edu	37	4	47593390	47593390	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:47593390G>A	uc003gxk.1	+	23	4437	c.4273G>A	c.(4273-4275)GAA>AAA	p.E1425K	ATP10D_uc003gxl.1_Missense_Mutation_p.E673K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1425	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CAAAGGTAAAGAAAGCTAGAT	0.418			NA											32	115					0	0	0.012213	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181263	57181263	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:57181263C>T	uc003hbk.2	+	8	1986	c.1595C>T	c.(1594-1596)ACC>ATC	p.T532I	KIAA1211_uc010iha.2_Missense_Mutation_p.T525I|KIAA1211_uc011bzz.1_Missense_Mutation_p.T442I|KIAA1211_uc003hbm.1_Missense_Mutation_p.T418I	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	532										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GAGAGACAGACCATGCCCCGG	0.647			NA											22	26					0	0	0.003954	0	0
LPHN3	23284	broad.mit.edu	37	4	62813870	62813870	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:62813870G>T	uc010ihh.2	+	14	2650	c.2477G>T	c.(2476-2478)CGT>CTT	p.R826L	LPHN3_uc003hcq.3_Missense_Mutation_p.R826L|LPHN3_uc003hct.2_Missense_Mutation_p.R219L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	813	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TACTCCAAGCGTACAATGACA	0.383			NA											10	37					7.48243e-07	8.12047e-07	0.006214	1	0
EPHA5	2044	broad.mit.edu	37	4	66231705	66231705	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:66231705T>A	uc003hcy.2	-	11	2188	c.1995A>T	c.(1993-1995)GAA>GAT	p.E665D	EPHA5_uc003hcx.2_Missense_Mutation_p.E597D|EPHA5_uc003hcz.2_Missense_Mutation_p.E643D|EPHA5_uc011cah.1_Missense_Mutation_p.E666D|EPHA5_uc011cai.1_Missense_Mutation_p.E644D|EPHA5_uc003hda.2_Missense_Mutation_p.E666D	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	665	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCTTAGCAAATTCGTGGACAG	0.358			NA								TSP Lung(17;0.13)			35	115					0	0	0.005524	0	0
STAP1	26228	broad.mit.edu	37	4	68441185	68441185	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:68441185T>A	uc003hde.3	+	3	357	c.275T>A	c.(274-276)CTT>CAT	p.L92H	STAP1_uc003hdf.2_Missense_Mutation_p.L92H	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	92	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						AAATTCACCCTTGTTTTGCCG	0.403			NA											10	53					0	0	0.008291	0	0
STAP1	26228	broad.mit.edu	37	4	68459051	68459051	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:68459051T>C	uc003hde.3	+	8	885	c.803T>C	c.(802-804)ATA>ACA	p.I268T	STAP1_uc003hdf.2_Missense_Mutation_p.I268T	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	268	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						AGACCATTTATATGTTCAACT	0.313			NA											29	102					0	0	0.008361	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68725387	68725387	+	Silent	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:68725387A>T	uc003hdq.2	-	2	83	c.18T>A	c.(16-18)CGT>CGA	p.R6R	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc011caj.1_Intron	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	6	Cytoplasmic (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TCGAAGTTACACGTGCTGGCC	0.408			NA											19	39					0	0	0.008871	0	0
CSN2	1447	broad.mit.edu	37	4	70823296	70823296	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:70823296G>T	uc003hes.3	-	5	384	c.371C>A	c.(370-372)CCC>CAC	p.P124H	CSN2_uc003het.3_Missense_Mutation_p.P123H	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	124					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						GTCAAAAAAGGGTATCGTTGG	0.478			NA											5	115					1.23904e-05	1.30146e-05	0.000602	1	0
RUFY3	22902	broad.mit.edu	37	4	71654656	71654656	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:71654656G>C	uc003hfq.2	+	11	1800	c.1205G>C	c.(1204-1206)AGA>ACA	p.R402T	RUFY3_uc003hfp.3_Missense_Mutation_p.R462T|RUFY3_uc011cax.1_Missense_Mutation_p.R420T|RUFY3_uc003hfr.2_Missense_Mutation_p.R402T|RUFY3_uc011cay.1_Missense_Mutation_p.R338T	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	402	Potential.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			GATGACCTCAGAGCTCTCAAG	0.507			NA											6	110					0	0	0.001168	0	0
BMP2K	55589	broad.mit.edu	37	4	79792085	79792085	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:79792085G>C	uc003hlk.2	+	11	1546	c.1380G>C	c.(1378-1380)CAG>CAC	p.Q460H	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.Q460H|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	460	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						ATCCTCACcagcagcagcagc	0.254			NA											3	123					0	0	0.004672	0	0
WDFY3	23001	broad.mit.edu	37	4	85694065	85694065	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:85694065G>C	uc003hpd.2	-	30	5180	c.4772C>G	c.(4771-4773)TCT>TGT	p.S1591C		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1591						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAAAGTAGAAGAAATAAACTG	0.328			NA											3	31					0	0	0.004672	0	0
GRID2	2895	broad.mit.edu	37	4	94032000	94032000	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:94032000C>A	uc011cdt.1	+	4	889	c.631C>A	c.(631-633)CTC>ATC	p.L211I	GRID2_uc010ikx.2_Missense_Mutation_p.L211I|GRID2_uc011cdu.1_Missense_Mutation_p.L116I|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	211	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GATTACCACTCTCTTTGACAC	0.418			NA											48	132					3.21987e-24	4.30488e-24	0.00361	1	0
AGXT2L1	64850	broad.mit.edu	37	4	109663766	109663766	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:109663766C>T	uc003hzc.2	-	13	1555	c.1374G>A	c.(1372-1374)ATG>ATA	p.M458I	AGXT2L1_uc010imc.2_Missense_Mutation_p.M452I|AGXT2L1_uc011cfm.1_Missense_Mutation_p.M418I|AGXT2L1_uc011cfn.1_Missense_Mutation_p.M385I|AGXT2L1_uc011cfo.1_Missense_Mutation_p.M400I	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	458					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CTTCTTTCAGCATCTGCAAGA	0.483			NA											28	90					0	0	0.007291	0	0
ALPK1	80216	broad.mit.edu	37	4	113356397	113356397	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:113356397A>T	uc003iap.3	+	12	3407	c.3128A>T	c.(3127-3129)AAA>ATA	p.K1043I	ALPK1_uc003ian.3_Missense_Mutation_p.K1043I|ALPK1_uc011cfx.1_Missense_Mutation_p.K965I|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.K871I	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1043	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GTGAAGAAAAAAGGCAGACAA	0.358			NA											72	225					0	0	0.00361	0	0
ANK2	287	broad.mit.edu	37	4	114275772	114275772	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:114275772G>C	uc003ibe.3	+	38	6098	c.5998G>C	c.(5998-6000)GGT>CGT	p.G2000R	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.G2015R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1967					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTTCCAGTCAGGTCAGGACCC	0.433			NA											42	119					0	0	0.007835	0	0
ARSJ	79642	broad.mit.edu	37	4	114899972	114899972	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:114899972C>T	uc003ibq.1	-	1	907	c.19G>A	c.(19-21)GCG>ACG	p.A7T	ARSJ_uc010imu.1_Missense_Mutation_p.A7T|ARSJ_uc010imv.1_5'UTR	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	7						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		GGATGCCCCGCACAGCCCCTG	0.662			NA											56	146					0	0	0.00361	0	0
PRDM5	11107	broad.mit.edu	37	4	121828674	121828674	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:121828674C>A	uc003idn.2	-	2	382	c.132G>T	c.(130-132)ATG>ATT	p.M44I	PRDM5_uc003ido.2_Missense_Mutation_p.M44I|PRDM5_uc010ine.2_Missense_Mutation_p.M44I|PRDM5_uc010inf.2_Missense_Mutation_p.M44I|PRDM5_uc003idp.1_Missense_Mutation_p.M44I	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	44	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						AGTCTTCAGGCATTCTCTTCT	0.323			NA											18	76					1.22574e-08	1.35121e-08	0.002299	1	0
FGF2	2247	broad.mit.edu	37	4	123813428	123813428	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:123813428C>A	uc003iev.1	+	3	812	c.744C>A	c.(742-744)TAC>TAA	p.Y248*		NM_002006	NP_001997	P09038	FGF2_HUMAN	fibroblast growth factor 2	248					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|lung(1)|central_nervous_system(1)	3					Pentosan Polysulfate(DB00686)	ACAATACTTACCGGTCAAGGA	0.358			NA											19	44					7.45023e-12	8.65074e-12	0.010504	1	0
DCHS2	54798	broad.mit.edu	37	4	155180804	155180804	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:155180804C>A	uc003inw.2	-	20	5317	c.5317G>T	c.(5317-5319)GTA>TTA	p.V1773L		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1773	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAGACTGCTACTTTGCAATAG	0.398			NA											45	65					3.61183e-13	4.24921e-13	0.00361	1	0
DCHS2	54798	broad.mit.edu	37	4	155241958	155241958	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:155241958G>C	uc003inw.2	-	14	3228	c.3228C>G	c.(3226-3228)GTC>GTG	p.V1076V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1076	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGCATTGAAGACATACACCA	0.443			NA											10	142					0	0	0.006214	0	0
PLRG1	5356	broad.mit.edu	37	4	155458507	155458507	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:155458507C>T	uc003iny.2	-	14	1479	c.1416G>A	c.(1414-1416)CAG>CAA	p.Q472Q	PLRG1_uc003inz.2_Silent_p.Q463Q	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	472	WD 7.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				GACTTTCAGACTGATCAAAAG	0.418			NA											22	56					0	0	0.012319	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160274748	160274748	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:160274748G>C	uc003iqg.3	+	22	4028	c.3718G>C	c.(3718-3720)GAT>CAT	p.D1240H		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1240					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CGCGTCACTTGATGCTGCTGA	0.537			NA											14	148					0	0	0.00245	0	0
GALNTL6	442117	broad.mit.edu	37	4	173269725	173269725	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:173269725C>T	uc003isv.2	+	5	1174	c.438C>T	c.(436-438)ATC>ATT	p.I146I		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	146	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GCATCATTATCCCATTTCATA	0.413			NA											28	96					0	0	0.010818	0	0
HAND2	9464	broad.mit.edu	37	4	174448469	174448469	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:174448469C>A	uc003ith.1	-	2	1551	c.613G>T	c.(613-615)GGC>TGC	p.G205C	HAND2_uc003itg.1_Missense_Mutation_p.G170V	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	205					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGCGGCCAGCCCGTCCGGCCT	0.502			NA											58	124					4.09171e-25	5.50051e-25	0.00361	1	0
ADAM29	11086	broad.mit.edu	37	4	175898632	175898632	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:175898632C>A	uc003iuc.2	+	5	2626	c.1956C>A	c.(1954-1956)AAC>AAA	p.N652K	ADAM29_uc003iud.2_Missense_Mutation_p.N652K|ADAM29_uc010irr.2_Missense_Mutation_p.N652K|ADAM29_uc011cki.1_Missense_Mutation_p.N652K	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	652	EGF-like.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACCCTCCCAACTGCCTGATAA	0.423	Ovarian(140;1727 1835 21805 25838 41440)		NA											29	40					1.74807e-11	2.01305e-11	0.010818	1	0
ASB5	140458	broad.mit.edu	37	4	177138085	177138085	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:177138085A>G	uc003iuq.1	-	6	762	c.746T>C	c.(745-747)GTA>GCA	p.V249A	ASB5_uc003iup.1_Missense_Mutation_p.V196A	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	249	ANK 6.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CAGTAAGTTTACAATTTCTGT	0.408			NA											53	108					0	0	0.00361	0	0
TRIML2	205860	broad.mit.edu	37	4	189012758	189012758	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr4:189012758G>C	uc003izl.2	-	7	969	c.933C>G	c.(931-933)CTC>CTG	p.L311L	TRIML2_uc003izj.1_Silent_p.L139L|TRIML2_uc003izk.1_Silent_p.L119L|TRIML2_uc011cle.1_Silent_p.L386L	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	311	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTTCCAGGAAGAGCCTTTTCA	0.532			NA											39	184					0	0	0.00623	0	0
ZDHHC11	79844	broad.mit.edu	37	5	837564	837564	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:837564G>T	uc011cma.1	-	6	1200	c.816C>A	c.(814-816)CTC>CTA	p.L272L	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	272						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGTTATTAATGAGATACTCAA	0.493			NA											5	196					2.7689e-08	3.04547e-08	0.001984	1	0
SLC6A18	348932	broad.mit.edu	37	5	1243781	1243781	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:1243781C>A	uc003jby.1	+	9	1366	c.1243C>A	c.(1243-1245)CTA>ATA	p.L415I		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	415	Helical; Name=8; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CACCTTGGGGCTATCGACCAT	0.657			NA											31	95					2.08457e-15	2.53459e-15	0.010818	1	0
CLPTM1L	81037	broad.mit.edu	37	5	1318514	1318514	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:1318514C>G	uc003jch.2	-	17	1633	c.1587G>C	c.(1585-1587)GAG>GAC	p.E529D	CLPTM1L_uc003jcg.2_Missense_Mutation_p.E360D	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	529	Cytoplasmic (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GCGTGGCCTTCTCCTCGTAGG	0.557			NA											20	121					0	0	0.012319	0	0
ADCY2	108	broad.mit.edu	37	5	7743826	7743826	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:7743826G>T	uc003jdz.1	+	15	1984	c.1917G>T	c.(1915-1917)CTG>CTT	p.L639L	ADCY2_uc011cmo.1_Silent_p.L459L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	639	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TTCTCTTGCTGGCCTTCATCC	0.483			NA											136	365					3.67666e-70	5.77424e-70	0.00361	1	0
MARCH11	441061	broad.mit.edu	37	5	16067857	16067857	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:16067857C>T	uc003jfo.2	-	4	1145	c.932G>A	c.(931-933)CGC>CAC	p.R311H	MARCH11_uc010itw.1_Missense_Mutation_p.R67H	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	311						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AGCTCGCCAGCGCTTAAACAC	0.428			NA											43	47					0	0	0.011902	0	0
FAM134B	54463	broad.mit.edu	37	5	16477889	16477889	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:16477889G>A	uc003jfs.2	-	8	920	c.882C>T	c.(880-882)CTC>CTT	p.L294L	FAM134B_uc003jfr.2_Silent_p.L153L	NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	294					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						CAGCAACCGTGAGGCTAATCT	0.413			NA											4	123					0	0	0.009096	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126342	32126342	+	Silent	SNP	C	C	A	rs147714399		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:32126342C>A	uc003jhp.1	-	4	1158	c.873G>T	c.(871-873)GCG>GCT	p.A291A		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	291					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						CCGCCACCACCGCCCACAGAA	0.498			NA											75	187					6.09464e-36	8.82237e-36	0.00361	1	0
SLC1A3	6507	broad.mit.edu	37	5	36677035	36677035	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:36677035C>A	uc003jkj.3	+	6	1085	c.609C>A	c.(607-609)ATC>ATA	p.I203I	SLC1A3_uc011cox.1_Silent_p.I96I|SLC1A3_uc010iuy.2_Silent_p.I203I	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	203	Extracellular (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	AAGTGCCCATCCAGGCCAACG	0.368			NA											13	52					7.93312e-07	8.58108e-07	0.00245	1	0
NIPBL	25836	broad.mit.edu	37	5	36985082	36985082	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:36985082T>C	uc003jkl.3	+	10	2299	c.1800T>C	c.(1798-1800)CCT>CCC	p.P600P	NIPBL_uc003jkk.3_Silent_p.P600P|NIPBL_uc003jkm.1_Silent_p.P479P	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	600					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTGAGACACCTAAAAAAAAGT	0.358			NA											3	97					0	0	0.004672	0	0
RICTOR	253260	broad.mit.edu	37	5	38967476	38967476	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:38967476C>T	uc003jlp.2	-	13	1138	c.1114G>A	c.(1114-1116)GAG>AAG	p.E372K	RICTOR_uc003jlo.2_Missense_Mutation_p.E372K|RICTOR_uc010ivf.2_Missense_Mutation_p.E87K	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	372					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GTTTTTGCCTCAGCTGCCACA	0.368			NA											15	110					0	0	0.003163	0	0
ITGA1	3672	broad.mit.edu	37	5	52206177	52206177	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:52206177G>T	uc003jou.2	+	14	1837	c.1785G>T	c.(1783-1785)CTG>CTT	p.L595L	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Silent_p.L126L	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	595	Extracellular (Potential).|FG-GAP 6.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GAGCTCCGCTGGAAGATGATC	0.438			NA											20	39					1.96292e-10	2.23682e-10	0.010504	1	0
ESM1	11082	broad.mit.edu	37	5	54281066	54281066	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:54281066C>T	uc003jpk.2	-	1	349	c.280G>A	c.(280-282)GAA>AAA	p.E94K	ESM1_uc010ivt.2_Missense_Mutation_p.E94K	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	94	IGFBP N-terminal.				angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			CCAAACTCTTCACCAAAAGGA	0.562			NA											87	147					0	0	0.00361	0	0
DDX4	54514	broad.mit.edu	37	5	55077767	55077767	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:55077767G>A	uc003jqg.3	+	10	657	c.583G>A	c.(583-585)GGT>AGT	p.G195S	DDX4_uc010ivz.2_Missense_Mutation_p.G175S|DDX4_uc003jqh.3_Missense_Mutation_p.G161S|DDX4_uc003jqj.2_Missense_Mutation_p.G62S	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	195	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TACAGGTAATGGTGATACTTC	0.338			NA											14	41					0	0	0.003163	0	0
ANKRD55	79722	broad.mit.edu	37	5	55407601	55407601	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:55407601G>T	uc003jqu.2	-	10	1126	c.974C>A	c.(973-975)CCT>CAT	p.P325H	ANKRD55_uc003jqt.2_Missense_Mutation_p.P37H	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	324	ANK 9.									skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GGGTCGAGTAGGCTCTGTTCT	0.488			NA											48	98					7.05377e-20	9.0009e-20	0.00361	1	0
CWC27	10283	broad.mit.edu	37	5	64081337	64081337	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:64081337G>T	uc003jtn.1	+	5	645	c.426G>T	c.(424-426)TTG>TTT	p.L142F	CWC27_uc003jtl.2_Missense_Mutation_p.L142F|CWC27_uc003jtm.2_Missense_Mutation_p.L142F|CWC27_uc010iwt.1_Missense_Mutation_p.L142F	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	142	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						ATAACATGTTGCGACTGTCAG	0.333			NA											43	141					4.44401e-20	5.68555e-20	0.010771	1	0
ADAMTS6	11174	broad.mit.edu	37	5	64492968	64492968	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:64492968T>A	uc003jtp.2	-	21	3400	c.2586A>T	c.(2584-2586)AGA>AGT	p.R862S	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	862	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CCACCTCCTGTCTTTGGACAC	0.423			NA											28	47					0	0	0.009535	0	0
TAF9	6880	broad.mit.edu	37	5	68660800	68660800	+	Silent	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:68660800A>G	uc003jwc.1	-	2	1097	c.765T>C	c.(763-765)GAT>GAC	p.D255D	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_Silent_p.D255D|TAF9_uc003jwe.1_Silent_p.D255D|TAF9_uc003jwf.1_Silent_p.D255D	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	255	Poly-Asp.				histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		catcatcatcatcgtcatcat	0.244			NA											4	122					0	0	0.009096	0	0
UTP15	84135	broad.mit.edu	37	5	72874903	72874903	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:72874903G>C	uc003kcw.1	+	11	1431	c.1208G>C	c.(1207-1209)AGA>ACA	p.R403T	UTP15_uc011cso.1_Missense_Mutation_p.R384T|UTP15_uc011csp.1_Missense_Mutation_p.R213T|UTP15_uc010ize.1_Missense_Mutation_p.R403T	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	403					rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TTAAATCGAAGAGGAGTCCTT	0.378			NA											4	60					0	0	0.000602	0	0
AP3B1	8546	broad.mit.edu	37	5	77523357	77523357	+	Splice_Site	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:77523357C>A	uc003kfj.2	-	5	501	c.376_splice	c.e5-1	p.D126_splice		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1						endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GGTTTGGGTCCTAAAAATAGT	0.333			NA							Hermansky-Pudlak_syndrome				20	43					4.96729e-08	5.44513e-08	0.008871	1	0
HAPLN1	1404	broad.mit.edu	37	5	82940454	82940454	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:82940454C>T	uc003kim.2	-	3	574	c.503G>A	c.(502-504)GGG>GAG	p.G168E	HAPLN1_uc003kin.2_Missense_Mutation_p.G168E	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	168	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		ATTGTAGCGCCCCAGTCGTGG	0.552			NA											17	28					0	0	0.006122	0	0
GPR98	84059	broad.mit.edu	37	5	90281197	90281197	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:90281197G>T	uc003kju.2	+	85	18106	c.18010G>T	c.(18010-18012)GAG>TAG	p.E6004*	GPR98_uc003kjt.2_Nonsense_Mutation_p.E3710*|GPR98_uc003kjw.2_Nonsense_Mutation_p.E1665*|GPR98_uc003kjx.2_Nonsense_Mutation_p.E32*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6004	Cytoplasmic (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGAATGATGAGCACACAGA	0.403			NA											13	37					9.31168e-06	9.82287e-06	0.001855	1	0
KCNN2	3781	broad.mit.edu	37	5	113740334	113740334	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:113740334C>A	uc003kqo.2	+	3	1239	c.782C>A	c.(781-783)CCA>CAA	p.P261Q		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	261	Helical; Name=Segment S4; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTATCTATACCAATGTTCTTA	0.428			NA											38	155					4.14481e-20	5.30969e-20	0.00623	1	0
DTWD2	285605	broad.mit.edu	37	5	118183839	118183839	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:118183839C>A	uc003ksa.2	-	5	706	c.672G>T	c.(670-672)CTG>CTT	p.L224L		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	224											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CTGCACACTCCAGTGTAGAAA	0.353			NA											26	56					1.26454e-06	1.36481e-06	0.005443	1	0
FTMT	94033	broad.mit.edu	37	5	121188292	121188292	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:121188292G>T	uc003kss.2	+	1	643	c.634G>T	c.(634-636)GTG>TTG	p.V212L		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	212	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		AGGTGACCACGTGCACAACTT	0.498			NA											78	177					1.88935e-48	2.83983e-48	0.00361	1	0
LMNB1	4001	broad.mit.edu	37	5	126158531	126158531	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:126158531A>T	uc003kud.1	+	8	1813	c.1445A>T	c.(1444-1446)TAT>TTT	p.Y482F	LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.Y272F	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	482	Tail.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		TCAGTCAGTTATAAATATACC	0.388			NA											17	16					0	0	0.007413	0	0
FBN2	2201	broad.mit.edu	37	5	127614386	127614386	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:127614386C>A	uc003kuu.2	-	57	7725	c.7286G>T	c.(7285-7287)GGA>GTA	p.G2429V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2429	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGGGCAGTTCCAGGAAGTGG	0.473			NA											36	110					4.17593e-13	4.9011e-13	0.007835	1	0
SLC27A6	28965	broad.mit.edu	37	5	128362826	128362826	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:128362826G>T	uc003kuy.2	+	8	1652	c.1256G>T	c.(1255-1257)GGA>GTA	p.G419V	SLC27A6_uc003kuz.2_Missense_Mutation_p.G419V	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	419					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTCTTGCAGGAGAACCTGGA	0.388			NA											18	55					2.35188e-11	2.70522e-11	0.006122	1	0
RAD50	10111	broad.mit.edu	37	5	131923747	131923747	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:131923747C>A	uc003kxi.2	+	7	1404	c.1017C>A	c.(1015-1017)CTC>CTA	p.L339L	RAD50_uc003kxh.2_Silent_p.L200L	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	339	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTAGGCTTCTCAATCAGGAAA	0.338			NA						Homologous_recombination					21	55					1.87028e-06	1.99877e-06	0.012319	1	0
PCBD2	84105	broad.mit.edu	37	5	134246156	134246156	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:134246156G>T	uc010jdz.2	+	2	236	c.216G>T	c.(214-216)CAG>CAT	p.Q72H	PCBD2_uc011cxw.1_Missense_Mutation_p.Q72H	NM_032151	NP_115527	Q9H0N5	PHS2_HUMAN	pterin-4 alpha-carbinolamine dehydratase 2	72					positive regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process		4-alpha-hydroxytetrahydrobiopterin dehydratase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTTTAATCAGGTAATTGTTA	0.403			NA											23	50					4.47668e-21	5.78779e-21	0.003954	1	0
IL9	3578	broad.mit.edu	37	5	135231470	135231470	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:135231470G>A	uc003lbb.1	-	1	47	c.36C>T	c.(34-36)CTC>CTT	p.L12L		NM_000590	NP_000581	P15248	IL9_HUMAN	interleukin 9 precursor	12					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGGAGCACAGGAGCAGGGCAG	0.572			NA											18	71					0	0	0.010504	0	0
TRPC7	57113	broad.mit.edu	37	5	135692704	135692704	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:135692704G>T	uc003lbn.1	-	1	372	c.369C>A	c.(367-369)GCC>GCA	p.A123A	TRPC7_uc010jef.1_Silent_p.A115A|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.A115A|TRPC7_uc010jei.1_Silent_p.A115A|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	124	Cytoplasmic (Potential).|ANK 3.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTTGAGGATGGCCTCCACGA	0.657			NA											43	68					1.32136e-16	1.62884e-16	0.00874	1	0
PKD2L2	27039	broad.mit.edu	37	5	137243525	137243525	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:137243525A>G	uc003lby.2	+	7	1126	c.1070A>G	c.(1069-1071)GAT>GGT	p.D357G	PKD2L2_uc003lbw.1_Missense_Mutation_p.D357G|PKD2L2_uc003lbx.2_Missense_Mutation_p.D357G|PKD2L2_uc011cyi.1_5'UTR	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	357	Extracellular (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AAATATTCAGATTTCTATTTT	0.274			NA											15	35					0	0	0.00245	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229520	140229520	+	Silent	SNP	G	G	A	rs146628059		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140229520G>A	uc003lhu.2	+	1	2164	c.1440G>A	c.(1438-1440)CGG>CGA	p.R480R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.R480R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	480	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCTGCGCGGGACGCTGACG	0.652	Melanoma(55;1800 1972 14909)		NA											56	157					0	0	0.00361	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572234	140572234	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140572234G>A	uc003lix.2	+	1	283	c.109G>A	c.(109-111)GAG>AAG	p.E37K		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	37	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGGTGACTGAGGAAACAGA	0.507			NA											65	120					0	0	0.00361	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683154	140683154	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140683154C>G	uc003ljf.2	-	1	459	c.279G>C	c.(277-279)AGG>AGC	p.R93S		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	93					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	CAGCCACTTTCCTGACAAACT	0.597			NA											3	132					0	0	0.004672	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683179	140683179	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140683179T>C	uc003ljf.2	-	1	434	c.254A>G	c.(253-255)TAC>TGC	p.Y85C		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	85	Helical; Name=2; (Potential).|Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	GCAGAACCCGTAGCACATGAA	0.592			NA											11	114					0	0	0.010729	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723888	140723888	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140723888C>A	uc003ljm.1	+	1	288	c.288C>A	c.(286-288)TGC>TGA	p.C96*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Nonsense_Mutation_p.C96*	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	96	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGCTCTGCGCTCAGATCC	0.448			NA											36	74					4.65686e-17	5.78419e-17	0.003755	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140731136	140731136	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:140731136C>A	uc003ljo.1	+	1	1309	c.1309C>A	c.(1309-1311)CAC>AAC	p.H437N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.H437N	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	437	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCACCCTGCACATCTCCGA	0.547			NA											17	52					1.40151e-16	1.72331e-16	0.010504	1	0
PCDH1	5097	broad.mit.edu	37	5	141244125	141244125	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:141244125T>A	uc003llq.2	-	3	1888	c.1771A>T	c.(1771-1773)AGC>TGC	p.S591C	PCDH1_uc003llp.2_Missense_Mutation_p.S591C|PCDH1_uc011dbf.1_Missense_Mutation_p.S569C	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	591	Extracellular (Potential).|Cadherin 5.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCCTGGAGGCTAGGACTGCCC	0.542	Ovarian(132;1609 1739 4190 14731 45037)		NA											10	85					0	0	0.006214	0	0
LARS	51520	broad.mit.edu	37	5	145552329	145552329	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:145552329T>A	uc003lnx.1	-	3	372	c.134A>T	c.(133-135)AAG>ATG	p.K45M	LARS_uc011dbq.1_Missense_Mutation_p.K45M|LARS_uc011dbr.1_Translation_Start_Site|LARS_uc011dbs.1_Missense_Mutation_p.K45M	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	45					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TACAAAATACTTGCCCTTGCT	0.358			NA											8	37					0	0	0.006214	0	0
FAT2	2196	broad.mit.edu	37	5	150914137	150914137	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:150914137G>A	uc003lue.3	-	12	9273	c.9260C>T	c.(9259-9261)GCG>GTG	p.A3087V	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_5'Flank	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3087	Extracellular (Potential).|Cadherin 27.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCATCCGTCGCCTTGGCAAC	0.562			NA											66	78					0	0	0.00361	0	0
GABRA1	2554	broad.mit.edu	37	5	161318005	161318005	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:161318005C>T	uc010jiw.2	+	9	1273	c.805C>T	c.(805-807)CAA>TAA	p.Q269*	GABRA1_uc010jix.2_Nonsense_Mutation_p.Q269*|GABRA1_uc010jiy.2_Nonsense_Mutation_p.Q269*|GABRA1_uc003lyx.3_Nonsense_Mutation_p.Q269*|GABRA1_uc010jiz.2_Nonsense_Mutation_p.Q269*|GABRA1_uc010jja.2_Nonsense_Mutation_p.Q269*|GABRA1_uc010jjb.2_Nonsense_Mutation_p.Q269*	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	269	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GATTCTCTCACAAGTCTCCTT	0.408			NA											42	80					0	0	0.009718	0	0
GABRG2	2566	broad.mit.edu	37	5	161569232	161569232	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:161569232C>A	uc003lyz.3	+	7	1190	c.832C>A	c.(832-834)CAG>AAG	p.Q278K	GABRG2_uc010jjc.2_Missense_Mutation_p.Q318K|GABRG2_uc003lyy.3_Missense_Mutation_p.Q278K|GABRG2_uc011dej.1_Missense_Mutation_p.Q183K	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	278	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTTTACCATCCAGACCTATAT	0.443			NA											36	134					4.46736e-08	4.90259e-08	0.005524	1	0
GABRG2	2566	broad.mit.edu	37	5	161580209	161580209	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:161580209C>A	uc003lyz.3	+	9	1597	c.1239C>A	c.(1237-1239)GAC>GAA	p.D413E	GABRG2_uc010jjc.2_Missense_Mutation_p.D461E|GABRG2_uc003lyy.3_Missense_Mutation_p.D421E|GABRG2_uc011dej.1_Missense_Mutation_p.D318E	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	413	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ACGGCAAGGACTGTGCCAGTT	0.458			NA											49	93					5.34276e-22	6.9812e-22	0.00361	1	0
WWC1	23286	broad.mit.edu	37	5	167891839	167891839	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:167891839G>T	uc003lzu.2	+	21	3115	c.3022G>T	c.(3022-3024)GAG>TAG	p.E1008*	WWC1_uc003lzv.2_Nonsense_Mutation_p.E1014*|WWC1_uc011den.1_Nonsense_Mutation_p.E1014*|WWC1_uc003lzw.2_Nonsense_Mutation_p.E807*|WWC1_uc010jjf.1_Nonsense_Mutation_p.E280*	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	1008	Potential.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ATTGACCCAGGAGATCTCGGT	0.607			NA											44	95					2.68985e-26	3.65104e-26	0.00361	1	0
NKX2-5	1482	broad.mit.edu	37	5	172660066	172660066	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:172660066G>T	uc003mcm.1	-	2	657	c.481C>A	c.(481-483)CGG>AGG	p.R161R	NKX2-5_uc011dfe.1_3'UTR|NKX2-5_uc010jjt.1_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	161	Homeobox.		R -> P (in CHNG5; exhibits a significant functional impairment with reduction of transactivation properties and dominant- negative effect which was associated with reduced DNA binding).		adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GACAGGTACCGCTGCTGCTTG	0.672	Esophageal Squamous(72;810 1219 2387 13420 44943)		NA											11	13					7.03913e-09	7.79474e-09	0.001368	1	0
EIF4E1B	253314	broad.mit.edu	37	5	176070154	176070154	+	Silent	SNP	G	G	T	rs143370383	by1000genomes	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:176070154G>T	uc010jkf.1	+	4	671	c.87G>T	c.(85-87)ACG>ACT	p.T29T		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	29					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGAGAGGACGCCCACAGGAG	0.507			NA											28	56					7.41945e-09	8.20662e-09	0.005443	1	0
GRM6	2916	broad.mit.edu	37	5	178416024	178416024	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:178416024G>T	uc003mjr.2	-	6	1445	c.1266C>A	c.(1264-1266)CTC>CTA	p.L422L	GRM6_uc010jla.1_Silent_p.L5L|GRM6_uc003mjs.1_Silent_p.L42L	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	422	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCCCAGGGCAGAGCGCCTGGT	0.627			NA											12	35					1.36491e-13	1.61158e-13	0.001855	1	0
CANX	821	broad.mit.edu	37	5	179143205	179143205	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:179143205G>A	uc003mkk.2	+	8	998	c.821G>A	c.(820-822)CGT>CAT	p.R274H	CANX_uc011dgp.1_Missense_Mutation_p.R309H|CANX_uc010jlb.1_Missense_Mutation_p.R210H|CANX_uc003mkl.2_Missense_Mutation_p.R274H|CANX_uc011dgq.1_Missense_Mutation_p.R166H	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	274	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATCCTTCACGTGAAATTGAG	0.448			NA											7	102					0	0	0.001984	0	0
SERPINB9	5272	broad.mit.edu	37	6	2892192	2892192	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:2892192G>C	uc003mug.2	-	6	719	c.598C>G	c.(598-600)CAG>GAG	p.Q200E	uc003mue.2_Intron|SERPINB9_uc003muf.2_Missense_Mutation_p.Q3E	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	200					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GTGGCCTCCTGATACATCATC	0.567			NA											32	163					0	0	0.003755	0	0
KIF13A	63971	broad.mit.edu	37	6	17764912	17764912	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:17764912G>C	uc003ncg.3	-	39	4952	c.4847C>G	c.(4846-4848)TCT>TGT	p.S1616C	KIF13A_uc003ncf.2_Missense_Mutation_p.S1568C|KIF13A_uc003nch.3_Missense_Mutation_p.S1581C|KIF13A_uc003nci.3_Missense_Mutation_p.S1568C|KIF13A_uc003nce.1_Missense_Mutation_p.S167C	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1616					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GCTGTCACTAGAAGGGACCAC	0.547			NA											7	50					0	0	0.001984	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862648	25862648	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:25862648T>C	uc003nfi.3	-	3	226	c.116A>G	c.(115-117)TAT>TGT	p.Y39C	SLC17A3_uc003nfk.3_Missense_Mutation_p.Y39C|SLC17A3_uc011djz.1_Missense_Mutation_p.Y39C|SLC17A3_uc011dka.1_Missense_Mutation_p.Y39C	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	39					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						GGCTATTCCATAGCGAGCAGA	0.353			NA											85	68					0	0	0.00361	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240785	26240785	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:26240785G>C	uc003nhe.1	+	1	132	c.132G>C	c.(130-132)GTG>GTC	p.V44V		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	44					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GCGGCGGCGTGAAACGCATTT	0.597			NA											6	88					0	0	0.001168	0	0
BTN2A2	10385	broad.mit.edu	37	6	26388325	26388325	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:26388325C>T	uc003nhq.2	+	4	613	c.527C>T	c.(526-528)CCA>CTA	p.P176L	BTN2A2_uc011dkf.1_Missense_Mutation_p.P60L|BTN2A2_uc011dkg.1_Intron|BTN2A2_uc003nhr.2_Missense_Mutation_p.P60L|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.P176L|BTN2A2_uc003nht.2_Missense_Mutation_p.P176L|BTN2A2_uc011dki.1_5'Flank	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	176	Extracellular (Potential).|Ig-like C2-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						GGGTGGTACCCAGAGCCCCTC	0.587			NA											51	74					0	0	0.00361	0	0
DHX16	8449	broad.mit.edu	37	6	30640537	30640537	+	Missense_Mutation	SNP	G	G	C	rs148435034		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:30640537G>C	uc003nqz.2	-	1	294	c.82C>G	c.(82-84)CAG>GAG	p.Q28E	DHX16_uc011dmo.1_Intron	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	28					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						ATCAGAAACTGGGCGACGTGC	0.672			NA											29	68					0	0	0.00632	0	0
C6orf27	80737	broad.mit.edu	37	6	31743834	31743834	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:31743834C>T	uc011dog.1	-	3	658	c.420G>A	c.(418-420)CTG>CTA	p.L140L	C6orf27_uc003nxd.2_Intron|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	140						extracellular region				ovary(3)	3						GAGCCCCTACCAGGCGCGCGC	0.657			NA											26	189					0	0	0.003954	0	0
SLC44A4	80736	broad.mit.edu	37	6	31836986	31836986	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:31836986G>A	uc010jti.2	-	13	1245	c.1179C>T	c.(1177-1179)AAC>AAT	p.N393N		NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	393	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GGGAGCTGATGTTGGATGCCC	0.567			NA											43	54					0	0	0.011902	0	0
NOTCH4	4855	broad.mit.edu	37	6	32166826	32166826	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:32166826A>G	uc003obb.2	-	24	4551	c.4412T>C	c.(4411-4413)ATC>ACC	p.I1471T	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Missense_Mutation_p.I134T|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1471	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TCGACGCCGGATGAGCTGGAG	0.622			NA											44	93					0	0	0.007835	0	0
TAP2	6891	broad.mit.edu	37	6	32803116	32803116	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:32803116T>A	uc003occ.2	-	4	791	c.760A>T	c.(760-762)AGC>TGC	p.S254C	TAP2_uc011dqf.1_Missense_Mutation_p.S254C|TAP2_uc003ocb.1_Missense_Mutation_p.S254C|TAP2_uc003ocd.2_Missense_Mutation_p.S254C	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	254	Cytoplasmic (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GTATCCGAGCTCAGCCGTGAG	0.542			NA											51	63					0	0	0.00361	0	0
PGC	5225	broad.mit.edu	37	6	41712451	41712451	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:41712451C>G	uc003ora.1	-	2	204	c.155G>C	c.(154-156)TGG>TCG	p.W52S		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	52				W -> S (in Ref. 9; AA sequence).	digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCGGTACTTCCAAGCAGGATC	0.542			NA											8	58					0	0	0.00308	0	0
PTCRA	171558	broad.mit.edu	37	6	42890948	42890948	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:42890948C>A	uc003osx.2	+	2	323	c.242C>A	c.(241-243)GCA>GAA	p.A81E	PTCRA_uc011duz.1_Missense_Mutation_p.Q92K|PTCRA_uc010jxx.1_Missense_Mutation_p.Q42K|PTCRA_uc010jxy.2_Missense_Mutation_p.A56E|PTCRA_uc010jxz.2_Intron	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	81	Extracellular (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CCTTCCCCAGCAACGGATGGC	0.622			NA											76	139					1.24833e-42	1.86205e-42	0.00361	1	0
SLC22A7	10864	broad.mit.edu	37	6	43266202	43266202	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:43266202C>T	uc003out.2	+	1	205	c.106C>T	c.(106-108)CTC>TTC	p.L36F	SLC22A7_uc010jyl.1_Missense_Mutation_p.L36F|SLC22A7_uc003ous.2_Missense_Mutation_p.L36F	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	36	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			ACTGCACTTCCTCCTGCCCAT	0.652			NA											41	96					0	0	0.009718	0	0
OPN5	221391	broad.mit.edu	37	6	47763229	47763229	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:47763229C>A	uc003ozc.2	+	4	691	c.686C>A	c.(685-687)TCT>TAT	p.S229Y	OPN5_uc003ozd.2_Missense_Mutation_p.S64Y	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	229	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						GTTAAGTCCTCTTCCAAAGAA	0.448	Melanoma(28;740 973 10870 42660 45347)		NA											48	95					3.05275e-18	3.81593e-18	0.013114	1	0
CRISP2	7180	broad.mit.edu	37	6	49676878	49676878	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:49676878G>C	uc003ozq.2	-	4	288	c.32C>G	c.(31-33)ACT>AGT	p.T11S	CRISP2_uc003ozl.2_Missense_Mutation_p.T11S|CRISP2_uc003ozn.2_Missense_Mutation_p.T11S|CRISP2_uc003ozr.2_Missense_Mutation_p.T11S|CRISP2_uc003ozo.2_Missense_Mutation_p.T11S|CRISP2_uc003ozm.2_Missense_Mutation_p.T11S|CRISP2_uc003ozp.2_Missense_Mutation_p.T11S	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	11						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGCAGCACAGTAACCAGAAA	0.388			NA											41	89					0	0	0.006999	0	0
CRISP3	10321	broad.mit.edu	37	6	49700930	49700930	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:49700930A>T	uc003ozs.2	-	6	514	c.499T>A	c.(499-501)TAT>AAT	p.Y167N		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	167					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TGGCAAACATAGTAGTATTTT	0.294			NA											70	112					0	0	0.00361	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683176	50683176	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:50683176G>A	uc003paf.2	+	2	899	c.387G>A	c.(385-387)GAG>GAA	p.E129E	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	129							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					GCCTGGACGAGCAGAGGCGGG	0.602			NA											38	194					0	0	0.00874	0	0
PKHD1	5314	broad.mit.edu	37	6	51612726	51612726	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:51612726C>G	uc003pah.1	-	58	9964	c.9688G>C	c.(9688-9690)GAT>CAT	p.D3230H	PKHD1_uc010jzn.1_Missense_Mutation_p.D1213H|PKHD1_uc003pai.2_Missense_Mutation_p.D3230H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3230	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGAGCTCTATCTGTTGATGTC	0.488			NA											7	182					0	0	0.004482	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142300	55142300	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:55142300G>C	uc003pcl.2	+	5	1200	c.885G>C	c.(883-885)CAG>CAC	p.Q295H	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	295	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAATAAAGCAGATCCGAGCCA	0.498			NA											21	36					0	0	0.010504	0	0
PHF3	23469	broad.mit.edu	37	6	64421138	64421138	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:64421138A>G	uc003pep.1	+	14	3903	c.3877A>G	c.(3877-3879)AGT>GGT	p.S1293G	PHF3_uc003pen.2_Missense_Mutation_p.S1205G|PHF3_uc011dxs.1_Missense_Mutation_p.S562G	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1293					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGCATACTTCAGTAGCAGAAA	0.373	GBM(135;136 1820 29512 34071 46235)		NA											37	55					0	0	0.005524	0	0
EYS	346007	broad.mit.edu	37	6	66094307	66094307	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:66094307C>A	uc011dxu.1	-	8	1809	c.1271G>T	c.(1270-1272)TGG>TTG	p.W424L	EYS_uc003peq.2_Missense_Mutation_p.W424L|EYS_uc003per.1_Missense_Mutation_p.W424L	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	424					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ATTGAAACACCATTCTTCATT	0.318			NA											21	27					3.01185e-09	3.35792e-09	0.003954	1	0
ELOVL4	6785	broad.mit.edu	37	6	80634699	80634699	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:80634699C>T	uc003pja.3	-	3	658	c.339G>A	c.(337-339)GTG>GTA	p.V113V	ELOVL4_uc011dyt.1_Intron	NM_022726	NP_073563	Q9GZR5	ELOV4_HUMAN	elongation of very long chain fatty acids-like	113					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			ovary(1)|skin(1)	2		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	TAGAATAATCCACACTCTGGC	0.308			NA											34	30					0	0	0.006999	0	0
BCKDHB	594	broad.mit.edu	37	6	80878689	80878689	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:80878689G>T	uc003pjd.2	+	5	642	c.575G>T	c.(574-576)GGG>GTG	p.G192V	BCKDHB_uc003pje.2_Missense_Mutation_p.G192V	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	192					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		GTTGGTCATGGGGCTCTCTAT	0.433			NA											66	75					4.67498e-28	6.47102e-28	0.00361	1	0
CYB5R4	51167	broad.mit.edu	37	6	84618742	84618742	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:84618742C>G	uc003pkf.2	+	4	477	c.345C>G	c.(343-345)GTC>GTG	p.V115V		NM_016230	NP_057314	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	115	Cytochrome b5 heme-binding.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(2)	2		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		ATCGTTGGGTCAATTATGAAT	0.418	Esophageal Squamous(86;1289 1332 25971 40349 52675)		NA											10	36					0	0	0.010729	0	0
MDN1	23195	broad.mit.edu	37	6	90394655	90394655	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:90394655G>C	uc003pnn.1	-	71	11885	c.11769C>G	c.(11767-11769)TTC>TTG	p.F3923L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3923					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCCGGTCAAAGAATTGCTTGT	0.403			NA											5	39					0	0	0.000602	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577087	90577087	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:90577087G>C	uc003pnr.2	+	8	4274	c.4078G>C	c.(4078-4080)GAA>CAA	p.E1360Q	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1360Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1360Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1360					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTGTACAACAGAAGAGCTAGT	0.413	Colon(187;1656 2025 17045 31481 39901)		NA											12	83					0	0	0.010729	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577210	90577210	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:90577210G>A	uc003pnr.2	+	8	4397	c.4201G>A	c.(4201-4203)GAT>AAT	p.D1401N	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.D1401N|CASP8AP2_uc011dzz.1_Missense_Mutation_p.D1401N	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1401					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GGTTCATCCTGATGTGTTGGA	0.378	Colon(187;1656 2025 17045 31481 39901)		NA											18	116					0	0	0.010504	0	0
BACH2	60468	broad.mit.edu	37	6	90642233	90642233	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:90642233C>G	uc011eab.1	-	9	3229	c.2420G>C	c.(2419-2421)AGA>ACA	p.R807T	BACH2_uc003pnw.2_Missense_Mutation_p.R807T	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	807						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AGGAGGTCCTCTCTCTGAGAA	0.567			NA											12	308					0	0	0.001368	0	0
AIM1	202	broad.mit.edu	37	6	106969284	106969284	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:106969284G>T	uc003prh.2	+	2	3464	c.2977G>T	c.(2977-2979)GAC>TAC	p.D993Y		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	993							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AAGCCGGTATGACCCAAGCAT	0.358			NA											56	36					3.53049e-34	5.0583e-34	0.00361	1	0
NR2E1	7101	broad.mit.edu	37	6	108496054	108496054	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:108496054G>T	uc003psg.2	+	3	941	c.186G>T	c.(184-186)GTG>GTT	p.V62V		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	62	Nuclear receptor.|NR C4-type.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GCTGTCCGGTGGACAAGACGC	0.587			NA											31	34					3.80469e-20	4.88676e-20	0.009535	1	0
NT5DC1	221294	broad.mit.edu	37	6	116432034	116432034	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:116432034G>T	uc003pwj.2	+	4	374	c.279G>T	c.(277-279)ATG>ATT	p.M93I	NT5DC1_uc003pwk.2_Missense_Mutation_p.M93I|NT5DC1_uc003pwl.2_Missense_Mutation_p.M43I	NM_152729	NP_689942	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase, cytosolic II-like 1 protein	93							hydrolase activity|metal ion binding				0		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		GCACCAAGATGATGACTCCAG	0.493	Colon(128;1440 1664 38087 41475 42869)		NA											6	79					1.26484e-09	1.41825e-09	0.00308	1	0
LAMA2	3908	broad.mit.edu	37	6	129498924	129498924	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:129498924C>G	uc003qbn.2	+	10	1485	c.1380C>G	c.(1378-1380)TAC>TAG	p.Y460*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.Y460*	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	460	Laminin EGF-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCAGGGGCTACACTGGCTACC	0.488			NA											10	99					0	0	0.008291	0	0
LAMA2	3908	broad.mit.edu	37	6	129498962	129498962	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:129498962G>A	uc003qbn.2	+	10	1523	c.1418G>A	c.(1417-1419)GGG>GAG	p.G473E	LAMA2_uc003qbo.2_Missense_Mutation_p.G473E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	473	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AACTGCAGTGGGTTAGGGAGC	0.483			NA											43	58					0	0	0.010771	0	0
OR2A4	79541	broad.mit.edu	37	6	132022492	132022492	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:132022492G>C	uc011ecd.1	-	1	50	c.50C>G	c.(49-51)CCC>CGC	p.P17R	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_030908	NP_112170	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		TGGGCCAACGGGAAATCCCAG	0.493			NA											18	85					0	0	0.00278	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138199845	138199845	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:138199845G>A	uc003qhr.2	+	7	1329	c.1263G>A	c.(1261-1263)CTG>CTA	p.L421L	TNFAIP3_uc003qhs.2_Silent_p.L421L	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	421	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TCCCAAAGCTGAACTCCAAGC	0.587	GBM(130;153 1739 22295 28918 47987)		NA	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								8	96					0	0	0.004482	0	0
UTRN	7402	broad.mit.edu	37	6	144758806	144758806	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:144758806G>C	uc003qkt.2	+	10	1257	c.1165G>C	c.(1165-1167)GAG>CAG	p.E389Q	UTRN_uc010khq.1_Missense_Mutation_p.E389Q	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	389	Interaction with SYNM.|Spectrin 2.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGAAGAATTTGAGATTCAGGA	0.507			NA											8	105					0	0	0.00308	0	0
UTRN	7402	broad.mit.edu	37	6	145069583	145069583	+	Missense_Mutation	SNP	G	G	A	rs141157215		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:145069583G>A	uc003qkt.2	+	54	8233	c.8141G>A	c.(8140-8142)CGG>CAG	p.R2714Q		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2714	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAGTCCGTGCGGAATGGCTGG	0.483			NA											5	45					0	0	0.000602	0	0
ESR1	2099	broad.mit.edu	37	6	152332868	152332868	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:152332868G>A	uc003qom.3	+	7	1544	c.1174G>A	c.(1174-1176)GTC>ATC	p.V392I	ESR1_uc010kin.2_Missense_Mutation_p.V392I|ESR1_uc010kio.2_Missense_Mutation_p.V394I|ESR1_uc010kip.2_Missense_Mutation_p.V391I|ESR1_uc003qon.3_Missense_Mutation_p.V392I|ESR1_uc003qoo.3_Missense_Mutation_p.V392I|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_Intron|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Missense_Mutation_p.V61I|ESR1_uc011eex.1_Missense_Mutation_p.V173I|ESR1_uc010kit.1_Intron|ESR1_uc011eey.1_Missense_Mutation_p.V129I	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	392	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GATTGGTCTCGTCTGGCGCTC	0.498			NA											7	131					0	0	0.001984	0	0
IGF2R	3482	broad.mit.edu	37	6	160500618	160500618	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:160500618C>T	uc003qta.2	+	38	5633	c.5485C>T	c.(5485-5487)CGC>TGC	p.R1829C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1829	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CCAGGTGACTCGCGACTCGCG	0.582			NA											3	27					0	0	0.009096	0	0
IQCE	23288	broad.mit.edu	37	7	2608628	2608628	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:2608628C>T	uc003smo.3	+	3	309	c.125C>T	c.(124-126)TCG>TTG	p.S42L	IQCE_uc010ksm.1_Missense_Mutation_p.S42L|IQCE_uc003sml.1_Missense_Mutation_p.S42L|IQCE_uc011jvy.1_Missense_Mutation_p.S26L|IQCE_uc011jvz.1_Intron|IQCE_uc003smk.3_Missense_Mutation_p.S26L|IQCE_uc003smn.3_Intron	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	42											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CCACCCACATCGCCAAGTAAG	0.488			NA											47	44					0	0	0.00361	0	0
RNF216	54476	broad.mit.edu	37	7	5662711	5662711	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:5662711T>A	uc003soy.1	-	17	2571	c.2381A>T	c.(2380-2382)CAG>CTG	p.Q794L	RNF216_uc010ksz.1_Missense_Mutation_p.Q416L|RNF216_uc010kta.1_Missense_Mutation_p.Q416L|RNF216_uc011jwj.1_Missense_Mutation_p.Q416L|RNF216_uc003sox.1_Missense_Mutation_p.Q851L	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	794	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CATCTGTGGCTGTGGCAGGTT	0.632			NA											109	142					0	0	0.00361	0	0
COL28A1	340267	broad.mit.edu	37	7	7412854	7412854	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:7412854C>A	uc003src.1	-	32	2800	c.2683G>T	c.(2683-2685)GTA>TTA	p.V895L	COL28A1_uc011jxe.1_Missense_Mutation_p.V578L	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	895	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		ACTTTTTTTACACCTGGCCTT	0.488			NA											47	92					5.34276e-22	6.9812e-22	0.00361	1	0
TMEM195	392636	broad.mit.edu	37	7	15584521	15584521	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:15584521G>T	uc003stb.1	-	3	455	c.285C>A	c.(283-285)ACC>ACA	p.T95T		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	95					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						AAATATAACTGGTCAGTTCAA	0.338			NA											81	147					2.20581e-54	3.35666e-54	0.00361	1	0
DNAH11	8701	broad.mit.edu	37	7	21723509	21723509	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:21723509C>G	uc003svc.2	+	33	5620	c.5589C>G	c.(5587-5589)TTC>TTG	p.F1863L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1863	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCCAGTACTTCTATGAATACT	0.428			NA							Kartagener_syndrome				36	315					0	0	0.002836	0	0
FKBP14	55033	broad.mit.edu	37	7	30058635	30058635	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:30058635C>T	uc003tal.1	-	3	598	c.454G>A	c.(454-456)GAC>AAC	p.D152N	FKBP14_uc010kvq.1_RNA	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	152	EF-hand 1.|1 (Potential).				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						AGTTTCCAGTCATCATTAAGA	0.343			NA											16	133					0	0	0.003163	0	0
EEPD1	80820	broad.mit.edu	37	7	36194470	36194470	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:36194470G>T	uc003tfa.2	+	2	1177	c.537G>T	c.(535-537)AGG>AGT	p.R179S		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	179					DNA repair		DNA binding				0						ACCTAGTGAGGATGGATGGTA	0.612			NA											55	114					1.4709e-25	1.991e-25	0.00361	1	0
ANLN	54443	broad.mit.edu	37	7	36438973	36438973	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:36438973G>T	uc003tff.2	+	3	662	c.458G>T	c.(457-459)CGG>CTG	p.R153L	ANLN_uc011kaz.1_Missense_Mutation_p.R65L|ANLN_uc003tfg.2_Missense_Mutation_p.R153L|ANLN_uc010kxe.2_Missense_Mutation_p.R153L	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	153	Nuclear localization.|Interaction with CD2AP.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						GCAGAGCAACGGCGCCGTTGG	0.448			NA											30	49					7.26314e-15	8.69094e-15	0.007291	1	0
AMPH	273	broad.mit.edu	37	7	38505777	38505777	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:38505777G>C	uc003tgu.2	-	8	731	c.662C>G	c.(661-663)GCG>GGG	p.A221G	AMPH_uc003tgv.2_Missense_Mutation_p.A221G|AMPH_uc003tgt.2_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	221	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						ACTCACCACCGCAATTTCCTT	0.353			NA											28	58					0	0	0.007291	0	0
URGCP	55665	broad.mit.edu	37	7	43916471	43916471	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:43916471C>T	uc003tiw.2	-	6	2648	c.2591G>A	c.(2590-2592)GGC>GAC	p.G864D	URGCP_uc003tiu.2_Missense_Mutation_p.G821D|URGCP_uc003tiv.2_Missense_Mutation_p.G789D|URGCP_uc003tix.2_Missense_Mutation_p.G855D|URGCP_uc003tiy.2_Missense_Mutation_p.G821D|URGCP_uc003tiz.2_Missense_Mutation_p.G821D|URGCP_uc011kbj.1_Missense_Mutation_p.G821D	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	864					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GAAGGCCAGGCCTGCCAGTGC	0.637			NA											6	132					0	0	0.001984	0	0
RASA4P	401331	broad.mit.edu	37	7	44073792	44073792	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:44073792T>C	uc011kbk.1	-	6	755	c.650A>G	c.(649-651)CAC>CGC	p.H217R	RASA4P_uc003tji.2_RNA|RASA4P_uc010kxx.2_RNA	NM_006989	NP_008920			RAS p21 protein activator 4 isoform 1												0						CTCTTTTTGGTGGCAGCAGCT	0.622			NA											59	40					0	0	0.00361	0	0
TNS3	64759	broad.mit.edu	37	7	47384412	47384412	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:47384412G>A	uc003tnv.2	-	20	2958	c.2591C>T	c.(2590-2592)CCG>CTG	p.P864L	TNS3_uc003tnw.2_Missense_Mutation_p.P864L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	864						focal adhesion	protein binding			ovary(4)	4						TGGGCTGAACGGAGGATGGCG	0.597			NA											9	186					0	0	0.006214	0	0
SUN3	256979	broad.mit.edu	37	7	48046872	48046872	+	Nonsense_Mutation	SNP	C	C	A	rs145833872		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:48046872C>A	uc003tof.2	-	6	479	c.382G>T	c.(382-384)GAA>TAA	p.E128*	SUN3_uc010kyq.2_Nonsense_Mutation_p.E28*|SUN3_uc003tog.2_Nonsense_Mutation_p.E128*|SUN3_uc011kcf.1_Nonsense_Mutation_p.E116*	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	128	Potential.					integral to membrane				central_nervous_system(1)	1						TCTATTTGTTCGATCAAAAAT	0.418			NA											63	80					5.7554e-21	7.42144e-21	0.00361	1	0
CDC14C	168448	broad.mit.edu	37	7	48965435	48965435	+	Silent	SNP	C	C	T	rs145329673	by1000genomes	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:48965435C>T	uc010kyv.1	+	1	1279	c.1167C>T	c.(1165-1167)GAC>GAT	p.D389D		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						ACAGTGATGACGACGAAATCA	0.463			NA											5	60					0	0	0.001855	0	0
COBL	23242	broad.mit.edu	37	7	51258687	51258687	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:51258687G>A	uc003tpr.3	-	4	730	c.545C>T	c.(544-546)CCA>CTA	p.P182L	COBL_uc003tps.2_Missense_Mutation_p.P182L|COBL_uc011kcl.1_Missense_Mutation_p.P182L|COBL_uc010kzc.2_Missense_Mutation_p.P182L|COBL_uc003tpt.2_Missense_Mutation_p.P182L|COBL_uc003tpp.3_5'UTR|COBL_uc003tpq.3_Missense_Mutation_p.P98L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	182										skin(3)|ovary(2)	5	Glioma(55;0.08)					ACAAATGACTGGGAGAATATT	0.527	NSCLC(189;2119 2138 12223 30818 34679)		NA											12	132					0	0	0.010729	0	0
ZNF716	441234	broad.mit.edu	37	7	57522870	57522870	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:57522870C>A	uc011kdi.1	+	3	370	c.258C>A	c.(256-258)CAC>CAA	p.H86Q		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TAGCCAAACACCCAGGTAGGT	0.443			NA											105	171					1.97301e-41	2.92078e-41	0.00361	1	0
HIP1	3092	broad.mit.edu	37	7	75174446	75174446	+	Missense_Mutation	SNP	C	C	G	rs138790100		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:75174446C>G	uc003uds.1	-	26	2641	c.2600G>C	c.(2599-2601)CGA>CCA	p.R867P	HIP1_uc011kfz.1_Missense_Mutation_p.R693P	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	867	Important for actin binding (By similarity).|I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TTCTGTCCATCGAGAGTTCTT	0.383			NA	T	PDGFRB	CMML								63	212					0	0	0.00361	0	0
ABCB1	5243	broad.mit.edu	37	7	87199501	87199501	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:87199501C>A	uc003uiz.1	-	6	743	c.325G>T	c.(325-327)GAA>TAA	p.E109*	ABCB1_uc011khc.1_Nonsense_Mutation_p.E109*	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	109	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTCATGTCTTCCTCCAGATTC	0.318			NA											79	39					9.90312e-32	1.3944e-31	0.00361	1	0
SAMD9L	219285	broad.mit.edu	37	7	92762732	92762732	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:92762732C>T	uc003umh.1	-	5	3769	c.2553G>A	c.(2551-2553)TTG>TTA	p.L851L	SAMD9L_uc003umj.1_Silent_p.L851L|SAMD9L_uc003umi.1_Silent_p.L851L|SAMD9L_uc010lfb.1_Silent_p.L851L|SAMD9L_uc003umk.1_Silent_p.L851L|SAMD9L_uc010lfc.1_Silent_p.L851L|SAMD9L_uc010lfd.1_Silent_p.L851L|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	851										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TACTGTCTGCCAATTTTGCAC	0.373			NA											40	98					0	0	0.006999	0	0
TECPR1	25851	broad.mit.edu	37	7	97862266	97862266	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:97862266T>A	uc003upg.2	-	12	1896	c.1691A>T	c.(1690-1692)CAC>CTC	p.H564L	TECPR1_uc003uph.1_Missense_Mutation_p.H494L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	564						integral to membrane	protein binding			pancreas(1)	1						GGACAGCATGTGTACCGAGGA	0.662			NA											5	91					0	0	0.000602	0	0
TRRAP	8295	broad.mit.edu	37	7	98582624	98582624	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:98582624G>T	uc003upp.2	+	61	9567	c.9358G>T	c.(9358-9360)GAA>TAA	p.E3120*	TRRAP_uc011kis.1_Nonsense_Mutation_p.E3091*|TRRAP_uc003upr.2_Nonsense_Mutation_p.E2808*	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3120	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GATGACAGCCGAATTTTATGC	0.299			NA											34	66					8.16277e-20	1.04025e-19	0.006999	1	0
MUC17	140453	broad.mit.edu	37	7	100681040	100681040	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:100681040G>T	uc003uxp.1	+	3	6396	c.6343G>T	c.(6343-6345)GCC>TCC	p.A2115S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2115	Extracellular (Potential).|33.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACGCCGGTGGCCAGTCCTGA	0.498			NA											326	170					3.77821e-141	5.99133e-141	0.00361	1	0
ASZ1	136991	broad.mit.edu	37	7	117007429	117007429	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:117007429T>C	uc003vjb.2	-	12	1315	c.1252A>G	c.(1252-1254)AAA>GAA	p.K418E	ASZ1_uc011kno.1_Missense_Mutation_p.K409E|ASZ1_uc011knp.1_Missense_Mutation_p.K210E	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	418					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCTTTTAGTTTGCAGACCTTT	0.328			NA											30	15					0	0	0.008361	0	0
GRM8	2918	broad.mit.edu	37	7	126086280	126086280	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:126086280C>A	uc003vlr.2	-	9	2888	c.2577G>T	c.(2575-2577)GTG>GTT	p.V859V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.V859V|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	859	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CAGCTGTCACCACAGCCTTGA	0.423			NA								HNSCC(24;0.065)			104	58					9.16707e-34	1.30958e-33	0.00361	1	0
PAX4	5078	broad.mit.edu	37	7	127251249	127251249	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:127251249G>T	uc010lld.1	-	9	1107	c.901C>A	c.(901-903)CCA>ACA	p.P301T	PAX4_uc003vmf.2_Missense_Mutation_p.P299T|PAX4_uc003vmg.1_Intron	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	312	Transcription repression.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCGGCTGTGGGGGCAAGTGG	0.577	Ovarian(113;737 1605 7858 27720 34092)		NA											13	12					3.35478e-16	4.11474e-16	0.003163	1	0
PLXNA4	91584	broad.mit.edu	37	7	132193099	132193099	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:132193099G>A	uc003vra.3	-	2	583	c.354C>T	c.(352-354)CTC>CTT	p.L118L	PLXNA4_uc003vrc.2_Silent_p.L118L|PLXNA4_uc003vrb.2_Silent_p.L118L	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	118	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGTCTATGAGGAGCATCTTGT	0.577			NA											37	64					0	0	0.005524	0	0
UBN2	254048	broad.mit.edu	37	7	138958816	138958816	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:138958816G>A	uc011kqr.1	+	11	1969	c.1969G>A	c.(1969-1971)GCA>ACA	p.A657T	UBN2_uc003vuv.2_Missense_Mutation_p.A380T	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	657										ovary(1)|skin(1)	2						CTGGATGCAGGCAAGGTAAGA	0.348			NA											31	24					0	0	0.010818	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672860	141672860	+	Silent	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:141672860C>G	uc003vwx.1	-	1	714	c.630G>C	c.(628-630)CTG>CTC	p.L210L		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	210	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					CAGAAGAAACCAGAAACAATA	0.448			NA											3	110					0	0	0.004672	0	0
CLCN1	1180	broad.mit.edu	37	7	143027884	143027884	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:143027884G>T	uc003wcr.1	+	8	960	c.873G>T	c.(871-873)GAG>GAT	p.E291D	CLCN1_uc011ktc.1_Translation_Start_Site|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Missense_Mutation_p.R87M	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	291			E -> K (in MCR).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TTAGCATCGAGGTCACCTCCA	0.557			NA											65	25					5.45122e-27	7.48207e-27	0.00361	1	0
OR2A25	392138	broad.mit.edu	37	7	143771609	143771609	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:143771609G>C	uc011ktx.1	+	1	297	c.297G>C	c.(295-297)CAG>CAC	p.Q99H		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GCATGACCCAGATGTTTCTGT	0.542			NA											30	77					0	0	0.008361	0	0
ASB10	136371	broad.mit.edu	37	7	150878331	150878331	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:150878331C>T	uc003wjm.1	-	3	1060	c.934G>A	c.(934-936)GAG>AAG	p.E312K	ASB10_uc003wjl.1_Missense_Mutation_p.E312K|ASB10_uc003wjn.1_Missense_Mutation_p.E252K	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	267	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGGTGGCCTCGGCATCGGTG	0.657			NA											6	30					0	0	0.001984	0	0
MLL3	58508	broad.mit.edu	37	7	151970866	151970866	+	Silent	SNP	T	T	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr7:151970866T>A	uc003wla.2	-	7	1155	c.936A>T	c.(934-936)GCA>GCT	p.A312A		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	312					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGCCGGCTCCTGCAGCACAAG	0.438	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								6	245					0	0	0.001168	0	0
CSMD1	64478	broad.mit.edu	37	8	2976080	2976080	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:2976080G>T	uc011kwk.1	-	42	6664	c.6274C>A	c.(6274-6276)CCC>ACC	p.P2092T	CSMD1_uc011kwj.1_Missense_Mutation_p.P1484T|CSMD1_uc010lrg.2_Missense_Mutation_p.P160T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2092	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAAATGGGGGTGGATCTGGA	0.408			NA											35	48					1.57019e-19	1.9881e-19	0.007835	1	0
MCPH1	79648	broad.mit.edu	37	8	6302793	6302793	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:6302793A>C	uc003wqi.2	+	8	1618	c.1550A>C	c.(1549-1551)GAC>GCC	p.D517A	MCPH1_uc003wqh.2_Missense_Mutation_p.D517A|MCPH1_uc011kwl.1_Missense_Mutation_p.D469A	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	517						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GGGAAAGAAGACGCATGCCCA	0.493	Colon(95;1448 1467 8277 34473 35819)		NA											33	50					0	0	0.003755	0	0
MSRA	4482	broad.mit.edu	37	8	10177447	10177447	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:10177447C>T	uc003wsx.2	+	5	688	c.491C>T	c.(490-492)ACC>ATC	p.T164I	MSRA_uc011kwx.1_Missense_Mutation_p.T124I|MSRA_uc011kwy.1_Missense_Mutation_p.T121I|MSRA_uc003wsz.2_Missense_Mutation_p.T121I|MSRA_uc003wsy.2_Missense_Mutation_p.T98I	NM_012331	NP_036463	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A isoform a	164					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity				0		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	ATCTACCCGACCTCTGCCAAG	0.577	NSCLC(88;1378 1469 30580 49103 52286)		NA											5	19					0	0	0.001168	0	0
PINX1	54984	broad.mit.edu	37	8	10622982	10622982	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:10622982C>A	uc003wth.2	-	7	949	c.916G>T	c.(916-918)GTA>TTA	p.V306L	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_3'UTR	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	306	Telomerase inhibitory domain (TID).				mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		GCTATCTCTACTGGTTTTTGC	0.522			NA											18	22					2.4624e-09	2.74846e-09	0.008871	1	0
PCM1	5108	broad.mit.edu	37	8	17796488	17796488	+	Silent	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:17796488G>C	uc003wyi.3	+	5	1004	c.582G>C	c.(580-582)GGG>GGC	p.G194G	PCM1_uc011kyh.1_Silent_p.G194G|PCM1_uc003wyj.3_Silent_p.G194G|PCM1_uc003wyg.2_Silent_p.G194G|PCM1_uc003wyh.2_Silent_p.G194G|PCM1_uc010lta.1_Silent_p.G194G	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	194					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		AAGAAGATGGGAGGGGAGAAC	0.408			NA	T	RET|JAK2	papillary thyroid|CML|MPD								23	23					0	0	0.00333	0	0
DOCK5	80005	broad.mit.edu	37	8	25166439	25166439	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:25166439A>C	uc003xeg.2	+	12	1327	c.1190A>C	c.(1189-1191)CAA>CCA	p.Q397P	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.Q111P|DOCK5_uc003xei.2_5'Flank	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	397						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CACAAAGGGCAAGGTACAGTC	0.493	Pancreas(145;34 1887 3271 10937 30165)		NA											18	22					0	0	0.007413	0	0
C8orf41	80185	broad.mit.edu	37	8	33369537	33369537	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:33369537C>T	uc003xjl.3	-	1	1120	c.595G>A	c.(595-597)GAG>AAG	p.E199K	C8orf41_uc003xjk.3_Missense_Mutation_p.E199K|C8orf41_uc010lvv.2_Missense_Mutation_p.E199K|C8orf41_uc003xjm.3_Missense_Mutation_p.E199K|C8orf41_uc003xjn.1_Missense_Mutation_p.E199K	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	199							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		CTCCCTTTCTCATCTTCATTT	0.483			NA											49	116					0	0	0.00361	0	0
RNF122	79845	broad.mit.edu	37	8	33416262	33416262	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:33416262C>A	uc003xjo.1	-	2	455	c.53G>T	c.(52-54)AGC>ATC	p.S18I		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	18						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		CTTGTTGGTGCTAACCAGTCC	0.493			NA											13	36					9.31168e-06	9.82287e-06	0.001855	1	0
ADAM2	2515	broad.mit.edu	37	8	39626924	39626924	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:39626924C>A	uc003xnj.2	-	12	1274	c.1199G>T	c.(1198-1200)TGT>TTT	p.C400F	ADAM2_uc003xnk.2_Missense_Mutation_p.C381F|ADAM2_uc011lck.1_Missense_Mutation_p.C400F|ADAM2_uc003xnl.2_Missense_Mutation_p.C274F	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	400	Extracellular (Potential).|Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTCAGTCCCACAGTCACACTC	0.423			NA											33	110					4.11147e-13	4.83123e-13	0.003755	1	0
MYST3	7994	broad.mit.edu	37	8	41790299	41790299	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:41790299G>A	uc010lxb.2	-	18	5983	c.5439C>T	c.(5437-5439)CCC>CCT	p.P1813P	MYST3_uc010lxc.2_Silent_p.P1813P|MYST3_uc003xon.3_Silent_p.P1813P	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1813					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			CCAAGTTTGGGGGTGGCGTCA	0.527			NA											43	178					0	0	0.00874	0	0
POTEA	340441	broad.mit.edu	37	8	43197344	43197344	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:43197344A>G	uc003xpz.1	+	11	1276	c.1233A>G	c.(1231-1233)ATA>ATG	p.I411M	POTEA_uc003xqa.1_Missense_Mutation_p.I365M	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	411										ovary(1)	1						AAAGCCAAATACATTCAGTGG	0.323			NA											62	51					0	0	0.00361	0	0
PRKDC	5591	broad.mit.edu	37	8	48866220	48866220	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:48866220C>A	uc003xqi.2	-	7	738	c.681G>T	c.(679-681)TTG>TTT	p.L227F	PRKDC_uc003xqj.2_Missense_Mutation_p.L227F|PRKDC_uc011ldh.1_Missense_Mutation_p.L227F	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	227					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAAGTGAGGACAACCCCTTCA	0.393	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					24	47					4.59853e-10	5.21592e-10	0.005443	1	0
RP1	6101	broad.mit.edu	37	8	55539407	55539407	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:55539407G>A	uc003xsd.1	+	4	3113	c.2965G>A	c.(2965-2967)GAG>AAG	p.E989K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	989					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCTATGTAAAGAGGGAGATAA	0.368	Colon(91;1014 1389 7634 14542 40420)		NA											52	120					0	0	0.00361	0	0
CHD7	55636	broad.mit.edu	37	8	61748754	61748754	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:61748754A>G	uc003xue.2	+	16	4378	c.3901A>G	c.(3901-3903)AAA>GAA	p.K1301E		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1301	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCTGCTGCCAAAACTGAAGGC	0.502			NA											28	21					0	0	0.00632	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744678	70744678	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:70744678G>T	uc003xyl.2	-	2	938	c.231C>A	c.(229-231)AAC>AAA	p.N77K	SLCO5A1_uc010lzb.2_Missense_Mutation_p.N77K|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.N77K|SLCO5A1_uc010lzc.2_Missense_Mutation_p.N77K	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	77	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGGCCAACGGGTTCGGGCCTT	0.652			NA									OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	26					2.95478e-19	3.72196e-19	0.00874	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885206	88885206	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:88885206C>A	uc003ydz.2	-	1	1091	c.994G>T	c.(994-996)GTG>TTG	p.V332L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	332	WD 2.									ovary(1)	1						TCCTGGCCCACGGCCGCCACG	0.567			NA											37	58					1.07637e-12	1.25876e-12	0.004878	1	0
ZFPM2	23414	broad.mit.edu	37	8	106813683	106813683	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:106813683C>T	uc003ymd.2	+	8	1396	c.1373C>T	c.(1372-1374)CCT>CTT	p.P458L	ZFPM2_uc011lhs.1_Missense_Mutation_p.P189L	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	458					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGATACAGCCTACAACAAAT	0.448			NA											34	91					0	0	0.012213	0	0
CSMD3	114788	broad.mit.edu	37	8	113293532	113293532	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:113293532G>T	uc003ynu.2	-	59	9538	c.9379C>A	c.(9379-9381)CGA>AGA	p.R3127R	CSMD3_uc003yns.2_Silent_p.R2329R|CSMD3_uc003ynt.2_Silent_p.R3087R|CSMD3_uc011lhx.1_Silent_p.R2958R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3127	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATCAATTCGGAAGACTTTC	0.398			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			48	71					5.13769e-22	6.73119e-22	0.00361	1	0
COL14A1	7373	broad.mit.edu	37	8	121209086	121209086	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:121209086G>T	uc003yox.2	+	6	758	c.493G>T	c.(493-495)GGT>TGT	p.G165C	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_5'UTR	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	165	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CCTGGTCGATGGTTCATGGAG	0.443			NA											60	232					1.13205e-32	1.60319e-32	0.00361	1	0
DERL1	79139	broad.mit.edu	37	8	124034969	124034969	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:124034969C>T	uc003ypl.2	-	5	694	c.408G>A	c.(406-408)CTG>CTA	p.L136L	DERL1_uc003ypm.2_Silent_p.L136L|DERL1_uc011lif.1_Intron|DERL1_uc003ypn.2_Silent_p.L136L	NM_024295	NP_077271	Q9BUN8	DERL1_HUMAN	Der1-like domain family, member 1 isoform a	136	Lumenal (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity				0	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TGTCTCTGTTCAGCTGGGCCC	0.413			NA									OREG0018957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	308					0	0	0.004482	0	0
MYC	4609	broad.mit.edu	37	8	128750661	128750661	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:128750661G>T	uc003ysh.1	+	3	666	c.153G>T	c.(151-153)AAG>AAT	p.K51N	MYC_uc003ysi.2_Missense_Mutation_p.K66N	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	51					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		ATATCTGGAAGAAATTCGAGC	0.657			3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	71					2.2871e-25	3.08726e-25	0.007835	1	0
TMEM71	137835	broad.mit.edu	37	8	133740123	133740123	+	Silent	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:133740123T>C	uc003ytp.2	-	6	823	c.594A>G	c.(592-594)GGA>GGG	p.G198G	TMEM71_uc003ytm.1_Silent_p.G20G|TMEM71_uc003ytn.2_Silent_p.G180G|TMEM71_uc003yto.2_Intron	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	199						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GGGAGTTTCCTCCAGGAGGCT	0.463			NA											38	271					0	0	0.00623	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996289	143996289	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:143996289G>T	uc003yxk.1	-	4	634	c.631C>A	c.(631-633)CTG>ATG	p.L211M		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	211					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGGCCAACCAGGCCCAGCCGC	0.617			NA							Familial_Hyperaldosteronism_type_I				45	72					1.62263e-30	2.2652e-30	0.00361	1	0
CYP11B2	1585	broad.mit.edu	37	8	143996511	143996511	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:143996511C>T	uc003yxk.1	-	3	549	c.546G>A	c.(544-546)GGG>GGA	p.G182G		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	182					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGGTCAGGCTCCCCCGGGCGT	0.647			NA							Familial_Hyperaldosteronism_type_I				5	69					0	0	0.00245	0	0
EPPK1	83481	broad.mit.edu	37	8	144940824	144940824	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:144940824G>T	uc003zaa.1	-	1	6611	c.6598C>A	c.(6598-6600)CTG>ATG	p.L2200M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2200						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCGTTTCCAGGTCCTGGAGC	0.587			NA											44	506					9.39024e-22	1.22373e-21	0.009718	1	0
PLEC	5339	broad.mit.edu	37	8	144992484	144992484	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:144992484G>A	uc003zaf.1	-	32	12086	c.11916C>T	c.(11914-11916)GAC>GAT	p.D3972D	PLEC_uc003zab.1_Silent_p.D3835D|PLEC_uc003zac.1_Silent_p.D3839D|PLEC_uc003zad.2_Silent_p.D3835D|PLEC_uc003zae.1_Silent_p.D3803D|PLEC_uc003zag.1_Silent_p.D3813D|PLEC_uc003zah.2_Silent_p.D3821D|PLEC_uc003zaj.2_Silent_p.D3862D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3972	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTGACAGCTGGTCGTGCGTGT	0.687			NA											4	39					0	0	0.000602	0	0
MAF1	84232	broad.mit.edu	37	8	145161115	145161115	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:145161115G>C	uc003zbc.1	+	4	850	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	117					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCGCAGCCATGAGTTCAGCCG	0.612			NA											13	155					0	0	0.001368	0	0
NFKBIL2	4796	broad.mit.edu	37	8	145661726	145661726	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr8:145661726G>C	uc011llg.1	-	17	2105	c.2090C>G	c.(2089-2091)CCC>CGC	p.P697R	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	697					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TTCTGGGCAGGGGCTCAAAGG	0.627			NA											49	205					0	0	0.00361	0	0
VLDLR	7436	broad.mit.edu	37	9	2646540	2646540	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:2646540A>G	uc003zhk.1	+	11	2088	c.1691A>G	c.(1690-1692)GAC>GGC	p.D564G	VLDLR_uc003zhl.1_Missense_Mutation_p.D564G|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.D523G	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	564	LDL-receptor class B 3.|Extracellular (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		ATAGCTGTGGACCCACTGTCT	0.458			NA											14	41					0	0	0.00245	0	0
PTPRD	5789	broad.mit.edu	37	9	8376003	8376003	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:8376003G>C	uc003zkk.2	-	38	5305	c.4594C>G	c.(4594-4596)CTA>GTA	p.L1532V	PTPRD_uc003zkp.2_Missense_Mutation_p.L1126V|PTPRD_uc003zkq.2_Missense_Mutation_p.L1125V|PTPRD_uc003zkr.2_Missense_Mutation_p.L1116V|PTPRD_uc003zks.2_Missense_Mutation_p.L1125V|PTPRD_uc003zkl.2_Missense_Mutation_p.L1523V|PTPRD_uc003zkm.2_Missense_Mutation_p.L1519V|PTPRD_uc003zkn.2_Missense_Mutation_p.L1121V|PTPRD_uc003zko.2_Missense_Mutation_p.L1122V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1532	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AAGAAAGCTAGAAAAGGTGTA	0.473			NA								TSP Lung(15;0.13)			4	119					0	0	0.009096	0	0
PTPRD	5789	broad.mit.edu	37	9	8633370	8633370	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:8633370G>T	uc003zkk.2	-	13	1010	c.299C>A	c.(298-300)GCC>GAC	p.A100D	PTPRD_uc003zkp.2_Missense_Mutation_p.A100D|PTPRD_uc003zkq.2_Missense_Mutation_p.A100D|PTPRD_uc003zkr.2_Missense_Mutation_p.A100D|PTPRD_uc003zks.2_Missense_Mutation_p.A100D|PTPRD_uc003zkl.2_Missense_Mutation_p.A100D|PTPRD_uc003zkm.2_Missense_Mutation_p.A100D|PTPRD_uc003zkn.2_Missense_Mutation_p.A100D|PTPRD_uc003zko.2_Missense_Mutation_p.A100D|PTPRD_uc003zkt.1_Missense_Mutation_p.A100D	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	100	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTATTTGAGGCCACACATTC	0.433			NA								TSP Lung(15;0.13)			108	44					4.44732e-65	6.94009e-65	0.00361	1	0
BNC2	54796	broad.mit.edu	37	9	16419222	16419222	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:16419222G>T	uc003zml.2	-	7	3205	c.3065C>A	c.(3064-3066)TCT>TAT	p.S1022Y	BNC2_uc011lmw.1_Missense_Mutation_p.S927Y|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.S809Y	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	1022					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GAACATAAGAGATCCTGAAAC	0.552			NA											69	39					1.49552e-23	1.99132e-23	0.00361	1	0
UBAP2	55833	broad.mit.edu	37	9	33988994	33988994	+	Missense_Mutation	SNP	C	C	T	rs112150520	by1000genomes	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:33988994C>T	uc003ztq.1	-	5	532	c.419G>A	c.(418-420)AGA>AAA	p.R140K	UBAP2_uc011loc.1_Missense_Mutation_p.R102K|UBAP2_uc011lod.1_5'UTR|UBAP2_uc011loe.1_Intron|UBAP2_uc011lof.1_Missense_Mutation_p.R65K|UBAP2_uc011log.1_Missense_Mutation_p.R139K|UBAP2_uc003ztr.2_Missense_Mutation_p.R65K	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	140										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ATTGCCGCCTCTTCCTTTCCG	0.323			NA											61	217					0	0	0.00361	0	0
TLN1	7094	broad.mit.edu	37	9	35707125	35707125	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:35707125C>A	uc003zxt.2	-	37	5253	c.4899G>T	c.(4897-4899)CTG>CTT	p.L1633L		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1633	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGTGGCCGGCCAGCACCGACC	0.592			NA											157	56					3.42498e-63	5.32775e-63	0.00361	1	0
MSMP	692094	broad.mit.edu	37	9	35753749	35753749	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:35753749C>T	uc003zyb.1	-	2	293	c.147G>A	c.(145-147)GAG>GAA	p.E49E		NM_001044264	NP_001037729	Q1L6U9	MSMP_HUMAN	PC3-secreted microprotein precursor	49						extracellular region					0						AATATTTCCCCTCATAGTGAC	0.537			NA											33	15					0	0	0.012213	0	0
FAM75A6	389730	broad.mit.edu	37	9	43628679	43628679	+	Missense_Mutation	SNP	G	G	C	rs2491538		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:43628679G>C	uc011lrb.1	-	3	292	c.263C>G	c.(262-264)CCG>CGG	p.P88R		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	88						integral to membrane					0						CAGGCCTCTCGGGCACTCTCT	0.582			NA											6	250					0	0	0.00308	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325435	79325435	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:79325435C>G	uc010mpk.2	-	8	1879	c.1755G>C	c.(1753-1755)TTG>TTC	p.L585F		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	585					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTGTCAGGCTCAAATTTCTTT	0.438			NA											66	28					0	0	0.00361	0	0
Unknown	0	broad.mit.edu	37	9	84676980	84676980	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:84676980C>A	uc010mpu.1	-	1	25	c.22G>T	c.(22-24)GAC>TAC	p.D8Y		NM_001164339	NP_001157811			hypothetical protein LOC404770												NA						AACGCCCAGTCCCTGGCCCAC	0.627			NA											36	19					6.97489e-18	8.7075e-18	0.004878	1	0
ROR2	4920	broad.mit.edu	37	9	94499775	94499775	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:94499775A>T	uc004arj.1	-	5	719	c.520T>A	c.(520-522)TGC>AGC	p.C174S	ROR2_uc004ari.1_Missense_Mutation_p.C34S|ROR2_uc004ark.2_Missense_Mutation_p.C174S	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	174	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TAAGGCTGGCAGAACCCATCC	0.512			NA											79	45					0	0	0.00361	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356939	104356939	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:104356939C>A	uc004bbr.2	-	1	345	c.274G>T	c.(274-276)GAG>TAG	p.E92*	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	89	EF-hand 3.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AACTTCTGCTCCTCGTCGCCC	0.537			NA											129	60					1.5108e-63	2.35387e-63	0.00361	1	0
KIAA0368	23392	broad.mit.edu	37	9	114135595	114135595	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:114135595C>A	uc004bfe.1	-	41	4803	c.4803G>T	c.(4801-4803)CGG>CGT	p.R1601R		NM_001080398	NP_001073867			KIAA0368 protein												0						TTTAACTCACCCGAACTAAAT	0.388			NA											151	63					1.26598e-50	1.91755e-50	0.00361	1	0
TLR4	7099	broad.mit.edu	37	9	120475527	120475527	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:120475527G>C	uc004bjz.2	+	3	1412	c.1121G>C	c.(1120-1122)AGC>ACC	p.S374T	TLR4_uc004bka.2_Missense_Mutation_p.S334T|TLR4_uc004bkb.2_Missense_Mutation_p.S174T	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	374	LRR 11.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GATCTACCAAGCCTTGAGTTT	0.388			NA											58	30					0	0	0.00361	0	0
DBC1	1620	broad.mit.edu	37	9	121929747	121929747	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:121929747C>A	uc004bkc.2	-	8	2357	c.1901G>T	c.(1900-1902)GGC>GTC	p.G634V		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	634					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GGGGCCCTGGCCAGTCTCATT	0.542			NA											189	93					3.56531e-90	5.62642e-90	0.00361	1	0
BAT2L1	84726	broad.mit.edu	37	9	134343086	134343086	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:134343086G>A	uc004can.3	+	12	1912	c.1857G>A	c.(1855-1857)AAG>AAA	p.K619K	BAT2L1_uc010mzj.1_Silent_p.K202K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	619	Gln-rich.						protein binding				0						AGGAGTTCAAGTATCAGAAGT	0.552			NA											55	20					0	0	0.00361	0	0
C9orf171	389799	broad.mit.edu	37	9	135447890	135447890	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:135447890A>C	uc004cbn.2	+	7	1004	c.956A>C	c.(955-957)CAC>CCC	p.H319P	C9orf171_uc004cbo.2_Missense_Mutation_p.H283P	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	319										ovary(4)|large_intestine(1)	5						AACTACACCCACCCCTAGCCC	0.597			NA											8	41					0	0	0.00499	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554876	135554876	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:135554876G>C	uc010mzv.2	+	2	2128	c.1870G>C	c.(1870-1872)GAA>CAA	p.E624Q	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	624					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		ACAGCAGGAAGAAGGCACTTC	0.537	Pancreas(142;417 1875 11086 31973 47667)		NA											77	131					0	0	0.00361	0	0
TMEM8C	389827	broad.mit.edu	37	9	136384097	136384097	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:136384097C>A	uc011mdk.1	-	3	298	c.298G>T	c.(298-300)GGC>TGC	p.G100C		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	100						integral to membrane					0						GTCAGGACGCCGAACATCACA	0.607			NA											123	48					1.51339e-41	2.24375e-41	0.00361	1	0
SARDH	1757	broad.mit.edu	37	9	136555519	136555519	+	Silent	SNP	A	A	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:136555519A>G	uc004cep.3	-	16	2186	c.2052T>C	c.(2050-2052)AGT>AGC	p.S684S	SARDH_uc004ceo.2_Silent_p.S684S|SARDH_uc011mdn.1_Silent_p.S684S|SARDH_uc011mdo.1_Silent_p.S516S|SARDH_uc004cen.2_Silent_p.S112S	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	684					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GGCCCTGGATACTGATCATAC	0.647			NA											15	79					0	0	0.003163	0	0
CACNA1B	774	broad.mit.edu	37	9	140866024	140866024	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:140866024G>C	uc004cog.2	+	11	1668	c.1523G>C	c.(1522-1524)CGG>CCG	p.R508P	CACNA1B_uc011mfd.1_Missense_Mutation_p.R39P	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	508	Extracellular (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AACCAGCCGCGGCGGCTTACC	0.612			NA											27	9					0	0	0.007291	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811608	5811608	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:5811608C>A	uc010ndh.2	-	6	2202	c.1701G>T	c.(1699-1701)CAG>CAT	p.Q567H	NLGN4X_uc004crp.2_Missense_Mutation_p.Q587H|NLGN4X_uc004crq.2_Missense_Mutation_p.Q567H|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q604H|NLGN4X_uc004crr.2_Missense_Mutation_p.Q567H|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q567H	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	567	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GCAGATAGAGCTGGTCTTTGG	0.463			NA											48	50					1.4709e-25	1.991e-25	0.00361	1	0
TLR7	51284	broad.mit.edu	37	X	12904260	12904260	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:12904260G>A	uc004cvc.2	+	3	772	c.633G>A	c.(631-633)CTG>CTA	p.L211L		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	211	Extracellular (Potential).|LRR 7.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TGCTCTCCCTGAAAGATAACA	0.358			NA											4	55					0	0	0.009096	0	0
TLR8	51311	broad.mit.edu	37	X	12938346	12938346	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:12938346T>C	uc004cve.2	+	2	1255	c.1187T>C	c.(1186-1188)TTA>TCA	p.L396S	TLR8_uc004cvd.2_Missense_Mutation_p.L414S	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	396	Extracellular (Potential).|LRR 11.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CTTCCAAACTTATCGACTATC	0.353			NA											59	63					0	0	0.00361	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237251	30237251	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:30237251A>T	uc004dbz.2	+	2	657	c.554A>T	c.(553-555)GAC>GTC	p.D185V		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	185	MAGE.						protein binding			ovary(1)	1						GACAAGGTAGACCTCACTGAT	0.502			NA											13	14					0	0	0.001855	0	0
FAM47B	170062	broad.mit.edu	37	X	34961344	34961344	+	Silent	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:34961344C>A	uc004ddi.1	+	1	414	c.396C>A	c.(394-396)GCC>GCA	p.A132A		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	132										ovary(3)|breast(1)	4						ATCCCTTGGCCATGTACCCCA	0.557			NA											62	62					3.79397e-19	4.7729e-19	0.00361	1	0
RPGR	6103	broad.mit.edu	37	X	38158228	38158228	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:38158228C>G	uc004ded.1	-	10	1394	c.1226G>C	c.(1225-1227)CGT>CCT	p.R409P	RPGR_uc004deb.2_Missense_Mutation_p.R409P|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA|RPGR_uc004dee.1_Missense_Mutation_p.R94P	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	409					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCGCCGCATACGTGCTGATAG	0.378			NA											21	51					0	0	0.003954	0	0
RBM10	8241	broad.mit.edu	37	X	47034417	47034417	+	Splice_Site	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:47034417G>C	uc004dhf.2	+	6	882	c.503_splice	c.e6-1	p.G168_splice	RBM10_uc004dhe.1_Intron|RBM10_uc004dhg.2_Splice_Site_p.G91_splice|RBM10_uc004dhh.2_Splice_Site_p.G168_splice|RBM10_uc010nhq.2_Splice_Site_p.G91_splice|RBM10_uc004dhi.2_Splice_Site_p.G233_splice	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1						mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GCTGTCTCCAGGTCAGAGCCG	0.532	Melanoma(171;120 2705 19495 39241)		NA											24	30					0	0	0.00278	0	0
CACNA1F	778	broad.mit.edu	37	X	49076962	49076962	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:49076962C>T	uc004dnb.2	-	19	2451	c.2389G>A	c.(2389-2391)GAA>AAA	p.E797K	CACNA1F_uc010nip.2_Missense_Mutation_p.E786K	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	797	Poly-Glu.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCCTCCTCTTCCTCTTTCTCC	0.587			NA											5	19					0	0	0.000602	0	0
CCNB3	85417	broad.mit.edu	37	X	50085236	50085236	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:50085236G>T	uc004dox.3	+	9	3850	c.3552G>T	c.(3550-3552)TTG>TTT	p.L1184F	CCNB3_uc004doy.2_Missense_Mutation_p.L1184F|CCNB3_uc004doz.2_Missense_Mutation_p.L80F|CCNB3_uc010njq.2_Missense_Mutation_p.L76F|CCNB3_uc004dpa.2_Missense_Mutation_p.L23F	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1184					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CCCTGTACTTGGCAGTGAAGC	0.478			NA											63	70					1.85135e-42	2.75733e-42	0.00361	1	0
Unknown	0	broad.mit.edu	37	X	51151342	51151342	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:51151342G>T	uc004dpj.2	+	1	1576	c.1474G>T	c.(1474-1476)GAG>TAG	p.E492*		NM_203407	NP_981952			hypothetical protein LOC340602												NA						GGCAGAAATAGAGAGCACAGC	0.507			NA											20	36					4.35082e-09	4.84523e-09	0.010504	1	0
PAGE5	90737	broad.mit.edu	37	X	55247847	55247847	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:55247847C>T	uc004duj.2	+	2	334	c.92C>T	c.(91-93)TCA>TTA	p.S31L	PAGE5_uc004duk.2_Missense_Mutation_p.S11L	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	31											0						TCCCAATCCTCAGAAAGAGGA	0.333			NA											3	36					0	0	0.009096	0	0
ZXDA	7789	broad.mit.edu	37	X	57935510	57935510	+	Missense_Mutation	SNP	G	G	T	rs138670514		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:57935510G>T	uc004dve.2	-	1	1558	c.1345C>A	c.(1345-1347)CCT>ACT	p.P449T		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	449	Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CAAAGGAAAGGTCTCTCGCCG	0.507			NA											6	109					0.000157383	0.000163558	0.00308	1	0
FOXO4	4303	broad.mit.edu	37	X	70320988	70320988	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:70320988G>T	uc004dys.1	+	2	1261	c.908G>T	c.(907-909)GGT>GTT	p.G303V	FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Missense_Mutation_p.G248V	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	303					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					CTCAATGAAGGTCTAGAGCTG	0.572			NA									OREG0019856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	30					1.22574e-08	1.35121e-08	0.002299	1	0
MED12	9968	broad.mit.edu	37	X	70341631	70341631	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:70341631C>T	uc004dyy.2	+	7	1265	c.1066C>T	c.(1066-1068)CGG>TGG	p.R356W	MED12_uc011mpq.1_Missense_Mutation_p.R356W|MED12_uc004dyz.2_Missense_Mutation_p.R356W|MED12_uc004dza.2_Missense_Mutation_p.R203W	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	356					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CCCTCAGCACCGGCCCCTGGT	0.577			NA											33	46					0	0	0.012213	0	0
NLGN3	54413	broad.mit.edu	37	X	70384145	70384145	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:70384145G>A	uc004dzd.1	+	5	1080	c.880G>A	c.(880-882)GTC>ATC	p.V294I	NLGN3_uc010nlb.1_Missense_Mutation_p.V254I|NLGN3_uc004dzb.2_Missense_Mutation_p.V274I|NLGN3_uc004dzc.2_Missense_Mutation_p.V157I|NLGN3_uc011mps.1_Missense_Mutation_p.V254I|NLGN3_uc004dze.2_Missense_Mutation_p.V92I|NLGN3_uc011mpr.1_Missense_Mutation_p.V254I	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	294	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					TGCATCCTGCGTCAGCCTCCT	0.597	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											9	48					0	0	0.006214	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74648925	74648925	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:74648925G>C	uc004ecg.2	-	7	1069	c.591C>G	c.(589-591)ATC>ATG	p.I197M	ZDHHC15_uc004ech.2_Missense_Mutation_p.I188M|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15 isoform 1	197	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(2)	2						TCCAGTATTTGATGAAATAGC	0.388			NA											5	54					0	0	0.000602	0	0
CHM	1121	broad.mit.edu	37	X	85149241	85149241	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:85149241G>A	uc004eet.2	-	12	1492	c.1462C>T	c.(1462-1464)CGG>TGG	p.R488W	CHM_uc011mqz.1_Missense_Mutation_p.R340W	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	488					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TCAATGACCCGAACAGCAAAA	0.378			NA											67	54					0	0	0.00361	0	0
KLHL4	56062	broad.mit.edu	37	X	86919909	86919909	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:86919909G>T	uc004efb.2	+	10	2253	c.2071G>T	c.(2071-2073)GAT>TAT	p.D691Y	KLHL4_uc004efa.2_Missense_Mutation_p.D691Y	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	691	Kelch 6.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TGAGTCATATGATGCACAGAG	0.333			NA											4	55					2.56e-06	2.72696e-06	0.009096	1	0
TCEAL5	340543	broad.mit.edu	37	X	102529380	102529380	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:102529380C>T	uc004ejz.1	-	3	407	c.112G>A	c.(112-114)GAG>AAG	p.E38K		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	38	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						ttttcttcctcgtctgacttt	0.06			NA											5	23					0	0	0.001168	0	0
KIAA1210	57481	broad.mit.edu	37	X	118250488	118250488	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:118250488G>A	uc004era.3	-	4	621	c.621C>T	c.(619-621)CCC>CCT	p.P207P		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	207										ovary(4)|skin(1)	5						TTTCCCGAACGGGCTGCAGAG	0.493			NA											19	21					0	0	0.002299	0	0
MCTS1	28985	broad.mit.edu	37	X	119746095	119746095	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:119746095G>A	uc004esx.2	+	6	870	c.522G>A	c.(520-522)CTG>CTA	p.L174L	MCTS1_uc011mub.1_Silent_p.L175L	NM_014060	NP_054779	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1 isoform 1	174					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0						ATGATGGGCTGTGGCATATGA	0.353			NA											6	182					0	0	0.001984	0	0
CT47B1	643311	broad.mit.edu	37	X	120008850	120008850	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:120008850C>G	uc011muc.1	-	1	930	c.675G>C	c.(673-675)GAG>GAC	p.E225D		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	225											0						ctgGGGGTTTCTCATCTGCGG	0.557			NA											21	237					0	0	0.008871	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299101	125299101	+	Silent	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:125299101G>T	uc004euk.1	-	1	834	c.807C>A	c.(805-807)GCC>GCA	p.A269A		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	269	WD 3.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TGCCGCTGAAGGCCAGGGCCC	0.637			NA											31	68					1.74807e-11	2.01305e-11	0.010818	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685659	125685659	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:125685659G>A	uc004eul.2	-	1	1184	c.933C>T	c.(931-933)TGC>TGT	p.C311C		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	311										skin(3)|ovary(1)	4						AGTAGGTCAGGCACACATTAT	0.592			NA											42	72					0	0	0.013114	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685862	125685862	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:125685862G>T	uc004eul.2	-	1	981	c.730C>A	c.(730-732)CAC>AAC	p.H244N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	244										skin(3)|ovary(1)	4						GGACGGATGTGGGCATATACG	0.652			NA											27	47					1.42536e-11	1.64529e-11	0.004656	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128884515	128884515	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:128884515G>C	uc004eut.1	+	8	953	c.709G>C	c.(709-711)GTC>CTC	p.V237L		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	237					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CCCGACTGCCGTCCTTCTGTC	0.597			NA											4	12					0	0	0.009096	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128945380	128945380	+	Splice_Site	SNP	A	A	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:128945380A>C	uc004euv.2	-	8	1250	c.881_splice	c.e8+1	p.S294_splice	ZDHHC9_uc004euw.2_Splice_Site_p.S294_splice	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9							endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						TGCCCTGAGCACCTGGGGGGC	0.527			NA											10	78					0	0	0.010729	0	0
BCORL1	63035	broad.mit.edu	37	X	129148236	129148236	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:129148236C>T	uc004evb.1	+	4	1602	c.1488C>T	c.(1486-1488)TCC>TCT	p.S496S	BCORL1_uc010nrd.1_Silent_p.S398S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	496	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGCTAGCCTCCCCCGAGCTCC	0.597			NA											47	233					0	0	0.00361	0	0
IGSF1	3547	broad.mit.edu	37	X	130410951	130410951	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:130410951C>A	uc004ewd.2	-	14	2808	c.2570G>T	c.(2569-2571)TGG>TTG	p.W857L	IGSF1_uc004ewe.3_Missense_Mutation_p.W851L|IGSF1_uc004ewf.2_Missense_Mutation_p.W837L	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	857	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GGGCTCAGACCAGATAGAAAA	0.567			NA											131	218					2.46087e-49	3.71023e-49	0.00361	1	0
FRMD7	90167	broad.mit.edu	37	X	131234702	131234703	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:131234702_131234703GG>AT	uc004ewn.2	-	2	277_278	c.99_100CC>AT	c.(97-102)AGCCAT>AGATAT	p.33_34SH>RY	FRMD7_uc011muy.1_Missense_Mutation_p.33_34SH>RY	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	33_34	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGATTTAGATGGCTGCAACTCA	0.376			NA											29	80					0	0	0.004672	0	0
SAGE1	55511	broad.mit.edu	37	X	134991835	134991835	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:134991835G>T	uc004ezh.2	+	14	1787	c.1620G>T	c.(1618-1620)ATG>ATT	p.M540I	SAGE1_uc010nry.1_Missense_Mutation_p.M509I|SAGE1_uc011mvv.1_Missense_Mutation_p.M164I	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	540										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAGAGAGGATGGAAAATAACC	0.418			NA											26	126					1.42536e-11	1.64529e-11	0.004656	1	0
GPR112	139378	broad.mit.edu	37	X	135482067	135482067	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:135482067G>T	uc004ezu.1	+	21	8658	c.8367G>T	c.(8365-8367)ATG>ATT	p.M2789I	GPR112_uc010nsb.1_Missense_Mutation_p.M2584I	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2789	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CACTACTGATGCTAAACCTGG	0.378			NA											23	107					6.44725e-10	7.3044e-10	0.002299	1	0
ZIC3	7547	broad.mit.edu	37	X	136649403	136649403	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:136649403C>A	uc004fak.2	+	1	1058	c.553C>A	c.(553-555)CAC>AAC	p.H185N		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	185					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CAACCAGGTCCACCTGGGGCT	0.692			NA											19	75					6.33239e-15	7.59576e-15	0.010504	1	0
MAGEC1	9947	broad.mit.edu	37	X	140993278	140993278	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:140993278G>T	uc004fbt.2	+	4	374	c.88G>T	c.(88-90)GAC>TAC	p.D30Y	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	30							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGGGGAGGACTCCCAGTC	0.577			NA								HNSCC(15;0.026)			71	90					2.69673e-31	3.78083e-31	0.00361	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995410	140995410	+	Silent	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:140995410C>T	uc004fbt.2	+	4	2506	c.2220C>T	c.(2218-2220)CTC>CTT	p.L740L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	740							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTTCTCTCCAGAGTCCTG	0.557			NA								HNSCC(15;0.026)			142	183					0	0	0.00361	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905168	144905168	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:144905168A>T	uc004fcd.2	+	5	2215	c.1225A>T	c.(1225-1227)AAC>TAC	p.N409Y	SLITRK2_uc010nsp.2_Missense_Mutation_p.N409Y|SLITRK2_uc010nso.2_Missense_Mutation_p.N409Y|SLITRK2_uc011mwq.1_Missense_Mutation_p.N409Y|SLITRK2_uc011mwr.1_Missense_Mutation_p.N409Y|SLITRK2_uc011mws.1_Missense_Mutation_p.N409Y|SLITRK2_uc004fcg.2_Missense_Mutation_p.N409Y|SLITRK2_uc011mwt.1_Missense_Mutation_p.N409Y	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	409	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTTAGGAAACAACAGGATTGC	0.403			NA											33	175					0	0	0.010818	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905556	144905556	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:144905556T>G	uc004fcd.2	+	5	2603	c.1613T>G	c.(1612-1614)ATG>AGG	p.M538R	SLITRK2_uc010nsp.2_Missense_Mutation_p.M538R|SLITRK2_uc010nso.2_Missense_Mutation_p.M538R|SLITRK2_uc011mwq.1_Missense_Mutation_p.M538R|SLITRK2_uc011mwr.1_Missense_Mutation_p.M538R|SLITRK2_uc011mws.1_Missense_Mutation_p.M538R|SLITRK2_uc004fcg.2_Missense_Mutation_p.M538R|SLITRK2_uc011mwt.1_Missense_Mutation_p.M538R	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	538	Extracellular (Potential).|LRRCT 2.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TGTGACATCATGGGGCTGAAA	0.493			NA											20	109					0	0	0.010504	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905908	144905908	+	Silent	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:144905908G>A	uc004fcd.2	+	5	2955	c.1965G>A	c.(1963-1965)AGG>AGA	p.R655R	SLITRK2_uc010nsp.2_Silent_p.R655R|SLITRK2_uc010nso.2_Silent_p.R655R|SLITRK2_uc011mwq.1_Silent_p.R655R|SLITRK2_uc011mwr.1_Silent_p.R655R|SLITRK2_uc011mws.1_Silent_p.R655R|SLITRK2_uc004fcg.2_Silent_p.R655R|SLITRK2_uc011mwt.1_Silent_p.R655R	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	655	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GCGTTCCCAGGAATACCAACA	0.438			NA											17	139					0	0	0.006122	0	0
FMR1	2332	broad.mit.edu	37	X	147014083	147014083	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:147014083A>T	uc010nst.2	+	8	959	c.770A>T	c.(769-771)GAA>GTA	p.E257V	FMR1_uc011mwz.1_Missense_Mutation_p.E257V|FMR1_uc004fcj.2_Missense_Mutation_p.E257V|FMR1_uc004fck.3_Missense_Mutation_p.E257V|FMR1_uc004fcl.3_Missense_Mutation_p.E118V|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	257					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GATCTAGATGAAGATACCTGC	0.363			NA							Fragile_X_syndrome				37	166					0	0	0.004878	0	0
AFF2	2334	broad.mit.edu	37	X	148035225	148035225	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:148035225A>T	uc004fcp.2	+	10	1992	c.1513A>T	c.(1513-1515)ACT>TCT	p.T505S	AFF2_uc004fcq.2_Missense_Mutation_p.T495S|AFF2_uc004fcr.2_Missense_Mutation_p.T466S|AFF2_uc011mxb.1_Missense_Mutation_p.T470S|AFF2_uc004fcs.2_Missense_Mutation_p.T472S|AFF2_uc011mxc.1_Missense_Mutation_p.T146S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	505					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTAGCACCACTGACAGCGA	0.602			NA											9	207					0	0	0.004482	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638404	149638404	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:149638404C>G	uc004fee.1	+	3	635	c.559C>G	c.(559-561)CAA>GAA	p.Q187E	MAMLD1_uc011mxt.1_Missense_Mutation_p.Q149E|MAMLD1_uc011mxu.1_Missense_Mutation_p.Q162E|MAMLD1_uc011mxv.1_Missense_Mutation_p.Q162E|MAMLD1_uc011mxw.1_Missense_Mutation_p.Q114E	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	187					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					CACCAAAATTCAAGACCCTTC	0.502			NA											27	170					0	0	0.005443	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303180	151303180	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:151303180C>T	uc004ffk.2	-	5	1321	c.913G>A	c.(913-915)GAA>AAA	p.E305K	MAGEA10_uc004ffl.2_Missense_Mutation_p.E305K	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	305	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTAATTTCAGCATGAGCC	0.502			NA											15	222					0	0	0.003163	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869911	151869911	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:151869911T>C	uc004ffq.1	+	3	795	c.601T>C	c.(601-603)TTC>CTC	p.F201L	MAGEA6_uc004ffr.1_Missense_Mutation_p.F201L|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	201	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CAAGACAGGCTTCCTGATAAT	0.557			NA											112	161					0	0	0.00361	0	0
CSAG1	158511	broad.mit.edu	37	X	151908883	151908883	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:151908883G>A	uc004fge.2	+	4	450	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	CSAG1_uc004fgf.2_Missense_Mutation_p.R41Q|CSAG1_uc004fgd.2_RNA	NM_153478	NP_705611	Q6PB30	CSAG1_HUMAN	chondrosarcoma associated gene 1 precursor	41										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAAACCACGAGCCTCCAGC	0.527			NA											41	347					0	0	0.007835	0	0
OPN1LW	5956	broad.mit.edu	37	X	153420159	153420159	+	Missense_Mutation	SNP	T	T	C	rs148583295	byFrequency	TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:153420159T>C	uc004fjz.3	+	4	722	c.689T>C	c.(688-690)ATC>ACC	p.I230T		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	230	Helical; Name=5; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCTGCATCATCCCACTCGCT	0.612			NA											71	322					0	0	0.00361	0	0
FLNA	2316	broad.mit.edu	37	X	153590628	153590628	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrX:153590628G>T	uc004fkk.2	-	18	2887	c.2638C>A	c.(2638-2640)CCT>ACT	p.P880T	FLNA_uc010nuu.1_Missense_Mutation_p.P880T	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	880	Filamin 7.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGAGGCCAGGGCCCTCGGCC	0.652			NA											17	106					3.51602e-12	4.09714e-12	0.008871	1	0
NLGN4Y	22829	broad.mit.edu	37	Y	16952392	16952392	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chrY:16952392G>T	uc004ftg.2	+	6	1953	c.1701G>T	c.(1699-1701)CAG>CAT	p.Q567H	NLGN4Y_uc004fte.2_Missense_Mutation_p.Q399H|NLGN4Y_uc011nas.1_Missense_Mutation_p.Q587H|NLGN4Y_uc004ftf.2_Missense_Mutation_p.Q260H|NLGN4Y_uc004fth.2_Missense_Mutation_p.Q567H	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	567	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						CCAAAGACCAGCTCTATCTGC	0.453			NA											17	11					1.77063e-15	2.15823e-15	0.005443	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74575176	74575177	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:74575176_74575177insT	uc001dfy.3	-	5	960_961	c.768_769insA	c.(766-771)AAATGGfs	p.K256fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	256_257										ovary(2)	2						ATGTAAATCCATTTTGCTTCAT	0.322			NA											41	79	---	---	---	---	NA	NA	NA	NA	NA
FAM189B	10712	broad.mit.edu	37	1	155220573	155220573	+	Frame_Shift_Del	DEL	C	C	-	rs76634237		TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:155220573delC	uc001fjm.2	-	9	1610	c.1004delG	c.(1003-1005)GGTfs	p.G335fs	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Frame_Shift_Del_p.G137fs|FAM189B_uc001fjn.2_Frame_Shift_Del_p.G239fs|FAM189B_uc001fjo.2_Frame_Shift_Del_p.G317fs|FAM189B_uc001fjp.2_Intron	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	335						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						AGGGAGGTCACCAATGGCTGA	0.672			NA									OREG0013858	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	29	---	---	---	---	NA	NA	NA	NA	NA
AVPR1B	553	broad.mit.edu	37	1	206224768	206224771	+	Frame_Shift_Del	DEL	GTCA	GTCA	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GTCA	GTCA	-	-	GTCA	GTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr1:206224768_206224771delGTCA	uc001hds.2	+	1	486_489	c.328_331delGTCA	c.(328-333)GTCAAGfs	p.V110fs		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	110_111	Helical; Name=3; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GTGCAGGGCCGTCAAGTACCTGCA	0.647			NA											19	82	---	---	---	---	NA	NA	NA	NA	NA
NELL1	4745	broad.mit.edu	37	11	20949981	20949981	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr11:20949981delC	uc001mqe.2	+	9	1106	c.953delC	c.(952-954)TCCfs	p.S318fs	NELL1_uc001mqf.2_Frame_Shift_Del_p.S318fs|NELL1_uc009yid.2_Frame_Shift_Del_p.S346fs|NELL1_uc010rdo.1_Frame_Shift_Del_p.S261fs|NELL1_uc010rdp.1_Frame_Shift_Del_p.S78fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	318	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TCCCCAGACTCCCTCCCAGTG	0.502			NA											31	71	---	---	---	---	NA	NA	NA	NA	NA
CD19	930	broad.mit.edu	37	16	28950038	28950039	+	Frame_Shift_Ins	INS	-	-	C			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:28950038_28950039insC	uc002drs.2	+	13	1590_1591	c.1528_1529insC	c.(1528-1530)GCCfs	p.A510fs	uc010vct.1_Intron|CD19_uc010byo.1_Frame_Shift_Ins_p.A511fs	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	510	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						CCTGTATGCAGCCCCCCAGCTC	0.609			NA											62	93	---	---	---	---	NA	NA	NA	NA	NA
ITGAX	3687	broad.mit.edu	37	16	31374335	31374335	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:31374335delC	uc002ebu.1	+	13	1506	c.1439delC	c.(1438-1440)GCCfs	p.A480fs	ITGAX_uc002ebt.2_Frame_Shift_Del_p.A480fs|ITGAX_uc010vfk.1_Frame_Shift_Del_p.A130fs	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	480	FG-GAP 5.|Extracellular (Potential).			A -> P (in Ref. 2; AAA51620).	blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCATCGGGGCCCCCCATTAC	0.677			NA											85	132	---	---	---	---	NA	NA	NA	NA	NA
ADCY7	113	broad.mit.edu	37	16	50324508	50324508	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr16:50324508delG	uc002egd.1	+	2	580	c.312delG	c.(310-312)TTGfs	p.L104fs	ADCY7_uc002egb.1_Frame_Shift_Del_p.L104fs|ADCY7_uc002egc.1_Frame_Shift_Del_p.L104fs	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	104	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GGGCCTGCTTGGTGGCGCTGG	0.647			NA											41	24	---	---	---	---	NA	NA	NA	NA	NA
KRT10	3858	broad.mit.edu	37	17	38978766	38978768	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr17:38978766_38978768delTCC	uc002hvi.2	-	1	96_98	c.70_72delGGA	c.(70-72)GGAdel	p.G24del	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	24	Head.|Gly-rich.			Missing (in Ref. 1; AAA60544).	epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				ctcctccacatcctcctcctcct	0.409			NA											7	64	---	---	---	---	NA	NA	NA	NA	NA
NPHS1	4868	broad.mit.edu	37	19	36342440	36342440	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr19:36342440delC	uc002oby.2	-	2	193	c.193delG	c.(193-195)GCCfs	p.A65fs		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	65	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCATCTTTGGCCCATTGCACC	0.667			NA											46	66	---	---	---	---	NA	NA	NA	NA	NA
SOS1	6654	broad.mit.edu	37	2	39213243	39213243	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:39213243delT	uc002rrk.3	-	23	3765	c.3724delA	c.(3724-3726)AGTfs	p.S1242fs	SOS1_uc002rrj.3_Frame_Shift_Del_p.S841fs	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	1242					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CCATGGTCACTTTTTTTGCCC	0.517			NA							Noonan_syndrome				7	254	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	141660521	141660522	+	Frame_Shift_Ins	INS	-	-	G			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:141660521_141660522insG	uc002tvj.1	-	23	4705_4706	c.3733_3734insC	c.(3733-3735)CTGfs	p.L1245fs	LRP1B_uc010fnl.1_Frame_Shift_Ins_p.L427fs	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1245	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCTACATCCAGCTTCCAACCT	0.371	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			10	114	---	---	---	---	NA	NA	NA	NA	NA
XIRP2	129446	broad.mit.edu	37	2	168099354	168099354	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr2:168099354delC	uc002udx.2	+	8	1470	c.1452delC	c.(1450-1452)GTCfs	p.V484fs	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Frame_Shift_Del_p.V309fs|XIRP2_uc010fpq.2_Frame_Shift_Del_p.V262fs|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	309					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GACTACCAGTCCCCAAAGATG	0.388			NA											77	49	---	---	---	---	NA	NA	NA	NA	NA
TMC2	117532	broad.mit.edu	37	20	2539151	2539151	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr20:2539151delG	uc002wgf.1	+	3	147	c.132delG	c.(130-132)GAGfs	p.E44fs	TMC2_uc002wgg.1_Frame_Shift_Del_p.E28fs|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	44	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						TCAAAGCCGAGGGGACCCCAG	0.682			NA											4	5	---	---	---	---	NA	NA	NA	NA	NA
ATR	545	broad.mit.edu	37	3	142279124	142279124	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr3:142279124delA	uc003eux.3	-	6	1644	c.1522delT	c.(1522-1524)TCTfs	p.S508fs		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	508					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TTTTGATGAGAACAATGAACA	0.368			NA						Other_conserved_DNA_damage_response_genes					38	73	---	---	---	---	NA	NA	NA	NA	NA
CDH9	1007	broad.mit.edu	37	5	26915767	26915768	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:26915767_26915768delGT	uc003jgs.1	-	3	662_663	c.493_494delAC	c.(493-495)ACTfs	p.T165fs	CDH9_uc010iug.2_Frame_Shift_Del_p.T165fs	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	165	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AACACTGGCAGTGTATAAGTCT	0.351	Melanoma(8;187 585 15745 40864 52829)		NA											46	161	---	---	---	---	NA	NA	NA	NA	NA
ISL1	3670	broad.mit.edu	37	5	50685513	50685513	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:50685513delG	uc003jor.2	+	4	1060	c.512delG	c.(511-513)CGGfs	p.R171fs		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	171					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				CCAGCCCTGCGGCCCCACGTC	0.597			NA											19	40	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS19	171019	broad.mit.edu	37	5	129072886	129072886	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:129072886delC	uc003kvb.1	+	23	3599	c.3599delC	c.(3598-3600)GCCfs	p.A1200fs	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1200					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GACTTCTATGCCCAAAAGCTG	0.473			NA											10	30	---	---	---	---	NA	NA	NA	NA	NA
FNIP1	96459	broad.mit.edu	37	5	131007363	131007364	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:131007363_131007364insT	uc003kvs.1	-	14	2915_2916	c.2773_2774insA	c.(2773-2775)ATTfs	p.I925fs	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Frame_Shift_Ins_p.I897fs|FNIP1_uc010jdm.1_Frame_Shift_Ins_p.I880fs	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	925					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCCTACAGCAATTTTTTTATCT	0.421			NA											29	114	---	---	---	---	NA	NA	NA	NA	NA
DOCK2	1794	broad.mit.edu	37	5	169267840	169267840	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr5:169267840delG	uc003maf.2	+	27	2863	c.2783delG	c.(2782-2784)CGGfs	p.R928fs	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Frame_Shift_Del_p.R420fs	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	928					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCATGGGCCGGGATCACATT	0.453			NA											14	58	---	---	---	---	NA	NA	NA	NA	NA
OR2J3	442186	broad.mit.edu	37	6	29080009	29080010	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:29080009_29080010delGT	uc011dll.1	+	1	342_343	c.342_343delGT	c.(340-345)GAGTGTfs	p.E114fs		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	114_115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAACCACAGAGTGTGTCCTACT	0.51			NA											178	584	---	---	---	---	NA	NA	NA	NA	NA
TTBK1	84630	broad.mit.edu	37	6	43251532	43251532	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr6:43251532delG	uc003ouq.1	+	14	3333	c.3054delG	c.(3052-3054)CCGfs	p.P1018fs		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1018						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCAATGGCCCGGCCCTTGCAG	0.667			NA											14	118	---	---	---	---	NA	NA	NA	NA	NA
PRDM12	59335	broad.mit.edu	37	9	133543701	133543702	+	Splice_Site	DEL	GT	GT	-			TCGA-75-6214-01A-41D-1945-08	TCGA-75-6214-10A-01D-1946-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	386c643d-476f-4d19-ab4b-2f33371f90ec	945fa648-2f7f-4447-83cb-18b2d40dbe3f	g.chr9:133543701_133543702delGT	uc004bzt.1	+	3	630	c.570_splice	c.e3+1	p.E190_splice		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCCATTGAGGTGTGTGTGTGT	0.594			NA											8	114	---	---	---	---	NA	NA	NA	NA	NA
