Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AJAP1	55966	broad.mit.edu	37	1	4829932	4829932	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:4829932C>A	uc001alm.1	+	3	1230	c.849C>A	c.(847-849)ATC>ATA	p.I283I	AJAP1_uc001aln.2_Silent_p.I283I	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	283	Helical; Signal-anchor for type III membrane protein; (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TCCATCAGATCATCACCATCA	0.542			NA											91	114					3.06722e-38	6.19537e-38	0.00361	1	0
CAMTA1	23261	broad.mit.edu	37	1	7723976	7723976	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:7723976C>T	uc001aoi.2	+	9	1576	c.1369C>T	c.(1369-1371)CCC>TCC	p.P457S		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GTCCATGCTGCCCACCAACGT	0.607			NA											11	83					0	0	0.008291	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001288	13001288	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:13001288T>G	uc001auq.2	-	3	481	c.395A>C	c.(394-396)AAA>ACA	p.K132T	PRAMEF5_uc001aur.2_Intron	NM_001010889	NP_001010889	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	132											0	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACTGGTGTTTTGTTCCTCTT	0.493			NA											43	729					0	0	0.002222	0	0
PRDM2	7799	broad.mit.edu	37	1	14106289	14106289	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:14106289C>G	uc001avi.2	+	8	2855	c.1999C>G	c.(1999-2001)CTT>GTT	p.L667V	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.L667V|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.L424V|PRDM2_uc001avk.2_Missense_Mutation_p.L466V|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	667						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTCTTTAAGTCTTCCTCTTAG	0.453			NA											29	28					0	0	0.007291	0	0
GRHL3	57822	broad.mit.edu	37	1	24658015	24658015	+	Silent	SNP	G	G	A	rs142785065		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:24658015G>A	uc001biy.2	+	2	178	c.132G>A	c.(130-132)CCG>CCA	p.P44P	GRHL3_uc001bix.2_Silent_p.P39P|GRHL3_uc001biz.2_Intron	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	39	Transcription activation.				regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TAGAAAACCCGTTGACAGCTG	0.493			NA											14	70					0	0	0.001855	0	0
ERMAP	114625	broad.mit.edu	37	1	43308742	43308742	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:43308742G>T	uc001cic.1	+	12	1537	c.1267G>T	c.(1267-1269)GTC>TTC	p.V423F	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.V423F|ERMAP_uc001cif.1_Missense_Mutation_p.V333F	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	423	Cytoplasmic (Potential).		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGAATCAATTGTCCCCAGGCC	0.478			NA											43	68					3.54561e-26	6.93211e-26	0.002222	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52800415	52800415	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52800415C>T	uc001cto.2	+	15	3817	c.3645C>T	c.(3643-3645)TAC>TAT	p.Y1215Y	ZFYVE9_uc001ctp.2_Silent_p.Y1156Y	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1215					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						CTTCTGGATACCTTGCCAAGT	0.403			NA											28	55					0	0	0.00632	0	0
ORC1L	4998	broad.mit.edu	37	1	52867035	52867035	+	Silent	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52867035A>G	uc001ctt.2	-	3	441	c.222T>C	c.(220-222)GAT>GAC	p.D74D	ORC1L_uc010oni.1_Silent_p.D74D|ORC1L_uc001ctu.2_Silent_p.D74D|ORC1L_uc009vzd.2_Intron	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	74	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						CAAACTCACCATCTTCGAACA	0.438			NA											16	107					0	0	0.004007	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52926859	52926859	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52926859C>A	uc001ctx.2	-	19	3502	c.3268G>T	c.(3268-3270)GCT>TCT	p.A1090S	ZCCHC11_uc001cty.2_Missense_Mutation_p.A1090S|ZCCHC11_uc001ctz.2_Missense_Mutation_p.A1090S|ZCCHC11_uc009vze.1_Missense_Mutation_p.A1090S|ZCCHC11_uc009vzf.1_Missense_Mutation_p.A849S|ZCCHC11_uc001cua.1_Missense_Mutation_p.A7S	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	1090					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						GGATCAATAGCTGCATAAGTA	0.279			NA											37	43					1.15183e-24	2.20949e-24	0.002222	1	0
C1orf175	374977	broad.mit.edu	37	1	55144499	55144499	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:55144499C>T	uc010ooe.1	+	11	2345	c.2021C>T	c.(2020-2022)CCG>CTG	p.P674L	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.P242L|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.P192L|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.P674L|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	674						integral to membrane	binding				0						CCTGTGAGCCCGTGCCAGAAC	0.587			NA											15	36					0	0	0.004007	0	0
LRRC7	57554	broad.mit.edu	37	1	70300548	70300548	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:70300548G>C	uc001dep.2	+	4	502	c.472G>C	c.(472-474)GGA>CGA	p.G158R	LRRC7_uc001deo.1_Missense_Mutation_p.G196R|LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	158	LRR 6.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGCCAATTTTGGAAGGTAAGA	0.388			NA											17	32					0	0	0.00499	0	0
LPHN2	23266	broad.mit.edu	37	1	82409007	82409007	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:82409007A>T	uc001dit.3	+	6	933	c.752A>T	c.(751-753)CAT>CTT	p.H251L	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.H251L|LPHN2_uc001div.2_Missense_Mutation_p.H251L|LPHN2_uc009wcd.2_Missense_Mutation_p.H251L	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	251	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCCAACTACCATGATACCTCA	0.403			NA											12	46					0	0	0.000978	0	0
S1PR1	1901	broad.mit.edu	37	1	101704965	101704965	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:101704965G>T	uc001dud.2	+	2	939	c.425G>T	c.(424-426)CGC>CTC	p.R142L	S1PR1_uc009weg.2_Missense_Mutation_p.R142L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	142	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCCATTGAGCGCTATATCACA	0.547			NA									OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	86					2.47872e-24	4.72507e-24	0.002522	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:145367767G>A	uc001end.3	+	85	10623	c.10588G>A	c.(10588-10590)GAA>AAA	p.E3530K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3455											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.254			NA											5	46					0	0	0.000602	0	0
THEM5	284486	broad.mit.edu	37	1	151820257	151820257	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:151820257G>T	uc009wnd.2	-	5	789	c.657C>A	c.(655-657)ATC>ATA	p.I219I		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	219							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCTGTGGGCGATGCAGGACA	0.582			NA											18	41					4.35082e-09	6.41062e-09	0.001523	1	0
FLG2	388698	broad.mit.edu	37	1	152324012	152324012	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:152324012G>T	uc001ezw.3	-	3	6323	c.6250C>A	c.(6250-6252)CAC>AAC	p.H2084N	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2084							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCAGAGTGAGCATGTCTA	0.532			NA											100	356					7.47877e-49	1.53089e-48	0.00361	1	0
DCST2	127579	broad.mit.edu	37	1	155006119	155006119	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:155006119G>A	uc001fgm.2	-	1	139	c.59C>T	c.(58-60)GCG>GTG	p.A20V	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	20	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CACAGCTCTCGCCATGCTAGG	0.602			NA											28	60					0	0	0.00632	0	0
NCSTN	23385	broad.mit.edu	37	1	160324028	160324028	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:160324028C>G	uc001fvx.2	+	11	1424	c.1300C>G	c.(1300-1302)CGA>GGA	p.R434G	NCSTN_uc001fvy.2_Missense_Mutation_p.R414G|NCSTN_uc010pjf.1_Missense_Mutation_p.R296G|NCSTN_uc001fvz.2_Missense_Mutation_p.R214G|NCSTN_uc010pjg.1_Missense_Mutation_p.R176G	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	434	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTTCGAGCTCGAAACATCTC	0.522			NA											17	85					0	0	0.00499	0	0
CD84	8832	broad.mit.edu	37	1	160523270	160523270	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:160523270G>T	uc001fwh.3	-	4	682	c.658C>A	c.(658-660)CGT>AGT	p.R220S	CD84_uc001fwf.3_Missense_Mutation_p.R220S|CD84_uc001fwg.3_Missense_Mutation_p.R220S|CD84_uc009wtn.2_Missense_Mutation_p.R220S|CD84_uc001fwi.3_Missense_Mutation_p.R106S|CD84_uc001fwj.2_Missense_Mutation_p.R220S	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	220	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGTGAGTACGGAAGCCCATT	0.493			NA											17	51					3.41278e-10	5.1786e-10	0.00499	1	0
ZNF648	127665	broad.mit.edu	37	1	182026538	182026538	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:182026538G>T	uc001goz.2	-	2	816	c.608C>A	c.(607-609)ACG>AAG	p.T203K		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTCTCTTGCGTGGGAAGGTC	0.592	NSCLC(71;908 1374 5429 20458 35642)		NA											21	18					0.00121646	0.00151437	0.008871	1	0
MARK1	4139	broad.mit.edu	37	1	220824025	220824025	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:220824025G>A	uc001hmn.3	+	14	2131	c.1534G>A	c.(1534-1536)GAT>AAT	p.D512N	MARK1_uc009xdw.2_Missense_Mutation_p.D512N|MARK1_uc010pun.1_Missense_Mutation_p.D512N|MARK1_uc001hmm.3_Missense_Mutation_p.D490N	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	512					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AAGGACCACAGATCGATACGT	0.383			NA											53	62					0	0	0.00361	0	0
ZNF678	339500	broad.mit.edu	37	1	227843408	227843408	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:227843408A>G	uc001hqw.1	+	4	1802	c.1457A>G	c.(1456-1458)GAG>GGG	p.E486G	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	541					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				CATACTGGAGAGAAACGCTAC	0.358			NA											17	36					0	0	0.004007	0	0
OR2T3	343173	broad.mit.edu	37	1	248637509	248637509	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:248637509C>G	uc001iel.1	+	1	858	c.858C>G	c.(856-858)TTC>TTG	p.F286L		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACACCATCTTCACTCCTGTGC	0.502			NA											63	271					0	0	0.00361	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17495594	17495594	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:17495594C>T	uc001ipd.2	-	2	164	c.164G>A	c.(163-165)CGG>CAG	p.R55Q	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	55	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						CGCCGGGCTCCGGAGCGTCCT	0.716			NA											4	2					0	0	0.000602	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60998401	60998401	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:60998401G>A	uc001jkk.3	+	4	798	c.532G>A	c.(532-534)GGA>AGA	p.G178R	PHYHIPL_uc001jkl.3_Missense_Mutation_p.G132R|PHYHIPL_uc001jkm.3_Missense_Mutation_p.G152R	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	178											0						AGTGATTGCAGGACGCATGCT	0.308			NA											20	69					0	0	0.007413	0	0
LRRTM3	347731	broad.mit.edu	37	10	68857466	68857466	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:68857466C>A	uc001jmz.1	+	3	2208	c.1658C>A	c.(1657-1659)ACG>AAG	p.T553K	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	553	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CAGGAAGATACGATGGAAACA	0.468			NA											12	60					2.27111e-07	3.09236e-07	0.001368	1	0
DDIT4	54541	broad.mit.edu	37	10	74034719	74034719	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:74034719C>T	uc001jsx.1	+	3	674	c.472C>T	c.(472-474)CAC>TAC	p.H158Y		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	158					apoptosis					pancreas(1)	1						CAAGAGCTGCCACAGCGTGGG	0.687			NA									OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0.006214	0	0
HPS6	79803	broad.mit.edu	37	10	103826990	103826990	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:103826990G>A	uc001kuj.2	+	1	1844	c.1759G>A	c.(1759-1761)GCA>ACA	p.A587T		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	587						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TGTGGAGCTGGCACAGCAGCA	0.662			NA							Hermansky-Pudlak_syndrome				22	33					0	0	0.001523	0	0
C10orf79	80217	broad.mit.edu	37	10	105944862	105944862	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:105944862C>G	uc001kxw.2	-	16	2169	c.2053G>C	c.(2053-2055)GGG>CGG	p.G685R	C10orf79_uc009xxq.2_5'UTR|C10orf79_uc001kxx.3_Missense_Mutation_p.G686R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	685	WD 9.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GACTGAATCCCATGACCCTGG	0.403			NA											3	51					0	0	0.004672	0	0
ATRNL1	26033	broad.mit.edu	37	10	117228685	117228685	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:117228685G>T	uc001lcg.2	+	24	3886	c.3500G>T	c.(3499-3501)GGA>GTA	p.G1167V	ATRNL1_uc010qsm.1_Missense_Mutation_p.G296V|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1167	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATTTTAGCTGGAACAATATCT	0.169			NA											7	10					2.0095e-06	2.71193e-06	0.001984	1	0
EMX2	2018	broad.mit.edu	37	10	119303110	119303110	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:119303110C>T	uc001ldh.3	+	1	1155	c.332C>T	c.(331-333)TCG>TTG	p.S111L	EMX2OS_uc001ldf.2_5'Flank|EMX2OS_uc001ldg.2_Intron|EMX2_uc001ldi.3_Missense_Mutation_p.S111L	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	111						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CTATTCGCCTCGCAGCAGCGG	0.697			NA											21	70					0	0	0.001882	0	0
HBBP1	3044	broad.mit.edu	37	11	5264337	5264337	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5264337A>C	uc001mag.2	-	2	365	c.149T>G	c.(148-150)CTG>CGG	p.L50R		NR_001589				Homo sapiens hemoglobin, beta pseudogene 1 (HBBP1), non-coding RNA.												0						ACTACTCACCAGGAAGTTCTC	0.458			NA											4	14					0	0	0.000248	0	0
OR51I2	390064	broad.mit.edu	37	11	5474928	5474928	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5474928T>A	uc010qzf.1	+	1	210	c.210T>A	c.(208-210)GAT>GAA	p.D70E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTTCAGTGATGTGGCCATAT	0.522			NA											20	52					0	0	0.008871	0	0
OR52N1	79473	broad.mit.edu	37	11	5809749	5809749	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5809749G>T	uc010qzo.1	-	1	298	c.298C>A	c.(298-300)CTC>ATC	p.L100I	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATCTGGGCGAGGCAGGCTTTA	0.517			NA											19	43					8.28177e-16	1.39555e-15	0.007413	1	0
OR52L1	338751	broad.mit.edu	37	11	6007176	6007177	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:6007176_6007177CC>AA	uc001mcd.2	-	1	1039_1040	c.984_985GG>TT	c.(982-987)AAGGAT>AATTAT	p.328_329KD>NY		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	328_329	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGATCAATCCTTTTGTGTAA	0.485	Melanoma(121;653 1666 10547 22796 51255)		NA											4	6					0	0	0.004672	0	0
CCKBR	887	broad.mit.edu	37	11	6291107	6291107	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:6291107C>T	uc001mcp.2	+	2	553	c.360C>T	c.(358-360)TTC>TTT	p.F120F	CCKBR_uc001mcq.2_Silent_p.F48F|CCKBR_uc001mcr.2_Silent_p.F120F|CCKBR_uc001mcs.2_Silent_p.F120F	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	120	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TGGGCACATTCATCTTTGGCA	0.587			NA											8	31					0	0	0.00308	0	0
SYT9	143425	broad.mit.edu	37	11	7441778	7441778	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:7441778A>T	uc001mfe.2	+	6	1616	c.1379A>T	c.(1378-1380)AAC>ATC	p.N460I	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	460	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAAGTAGGCAACGAGGCTGAG	0.463			NA											8	15					0	0	0.00308	0	0
OVCH2	341277	broad.mit.edu	37	11	7723352	7723352	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:7723352A>T	uc010rbf.1	-	5	470	c.470T>A	c.(469-471)TTT>TAT	p.F157Y		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GGGCCCCACAAAGTGGCCTGA	0.502			NA											6	7					0	0	0.001984	0	0
WT1	7490	broad.mit.edu	37	11	32413517	32413517	+	Splice_Site	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:32413517C>T	uc001mtn.1	-	9	1628	c.1432_splice	c.e9+1	p.S478_splice	WT1_uc001mtl.1_Intron|WT1_uc001mtm.1_Splice_Site_p.S249_splice|WT1_uc001mto.1_Intron|WT1_uc001mtp.1_Splice_Site_p.S461_splice|WT1_uc001mtq.1_Intron|WT1_uc009yjs.1_Splice_Site	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D						adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AGTTTACGCACTTGTTTTACC	0.378			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				30	88					0	0	0.003755	0	0
OR4X1	390113	broad.mit.edu	37	11	48285577	48285577	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:48285577C>T	uc010rht.1	+	1	165	c.165C>T	c.(163-165)TCC>TCT	p.S55S		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						TGCTCACCTCCCCCATGTATT	0.478			NA											16	27					0	0	0.006122	0	0
OR4X1	390113	broad.mit.edu	37	11	48286115	48286115	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:48286115C>A	uc010rht.1	+	1	703	c.703C>A	c.(703-705)CTC>ATC	p.L235I		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	235	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						GCACAAGGCCCTCTCCACCTG	0.537			NA											23	49					1.9806e-07	2.72109e-07	0.002299	1	0
FOLH1	2346	broad.mit.edu	37	11	49208288	49208288	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:49208288C>A	uc001ngy.2	-	5	808	c.547G>T	c.(547-549)GAA>TAA	p.E183*	FOLH1_uc001ngz.2_Nonsense_Mutation_p.E183*|FOLH1_uc009yly.2_Nonsense_Mutation_p.E168*|FOLH1_uc009ylz.2_Nonsense_Mutation_p.E168*|FOLH1_uc009yma.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	183	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAGAAGTCTTCAGTTCGTGCA	0.383			NA											9	47					0.00448238	0.00551261	0.004482	1	0
OR4C13	283092	broad.mit.edu	37	11	49974135	49974135	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:49974135G>T	uc010rhz.1	+	1	161	c.161G>T	c.(160-162)AGA>ATA	p.R54I		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CCATCACTGAGATCCCCCATG	0.428			NA											52	104					3.76997e-23	7.09778e-23	0.00361	1	0
OR4C6	219432	broad.mit.edu	37	11	55433305	55433305	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:55433305C>A	uc001nht.3	+	3	928	c.663C>A	c.(661-663)TGC>TGA	p.C221*	OR4C6_uc010rik.1_Nonsense_Mutation_p.C221*	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCATCCTATGCTCCCTGAAGT	0.507			NA											29	53					1.75199e-13	2.84232e-13	0.007291	1	0
CHKA	1119	broad.mit.edu	37	11	67864558	67864558	+	Silent	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:67864558A>T	uc001onj.2	-	2	604	c.390T>A	c.(388-390)CCT>CCA	p.P130P	CHKA_uc001onk.2_Silent_p.P130P	NM_001277	NP_001268	P35790	CHKA_HUMAN	choline kinase alpha isoform a	130					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)	CTGTGGTGTCAGGTAGGGAGC	0.512			NA											16	30					0	0	0.006122	0	0
ANO1	55107	broad.mit.edu	37	11	69972201	69972201	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:69972201G>C	uc001opj.2	+	10	1302	c.997G>C	c.(997-999)GCC>CCC	p.A333P	ANO1_uc001opk.1_Missense_Mutation_p.A305P|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.A68P	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	333	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCTGTACTTCGCCTGGCTGGG	0.537			NA											20	39					0	0	0.002299	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880349	74880349	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:74880349G>A	uc001owb.2	+	5	967	c.580G>A	c.(580-582)GTG>ATG	p.V194M	SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Missense_Mutation_p.V50M|SLCO2B1_uc010rrs.1_Missense_Mutation_p.V78M|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Missense_Mutation_p.V172M	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	194	Helical; Name=4; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	GATCATGTTCGTGGCACAGAC	0.612			NA											17	36					0	0	0.004007	0	0
PANX1	24145	broad.mit.edu	37	11	93913424	93913424	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:93913424G>T	uc001per.2	+	4	1586	c.1201_splice	c.e4+1	p.G401_splice	PANX1_uc001peq.2_Splice_Site_p.D401_splice	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1						positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAGCTCCAAGGTAGGGTTTGC	0.507			NA											3	20					0.00024832	0.000318225	0.000248	1	0
OR8D2	283160	broad.mit.edu	37	11	124189303	124189303	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:124189303G>T	uc010sah.1	-	1	791	c.791C>A	c.(790-792)TCC>TAC	p.S264Y		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AGTAGTGCTGGAAGGGGGCTT	0.448			NA											35	72					1.04594e-18	1.8334e-18	0.00623	1	0
VWF	7450	broad.mit.edu	37	12	6127901	6127901	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:6127901G>T	uc001qnn.1	-	28	4933	c.4683C>A	c.(4681-4683)ATC>ATA	p.I1561I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1561	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CCCGCTGCAGGATGTCCCCTT	0.468			NA											17	10					4.96729e-08	6.98167e-08	0.008871	1	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612			NA											3	9					0	0	0.004672	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398285	+	Missense_Mutation	DNP	CC	CC	TA	rs121913529		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:25398284_25398285CC>TA	uc001rgp.1	-	2	215_216	c.34_35GG>TA	c.(34-36)GGT>TAT	p.G12Y	KRAS_uc001rgq.1_Missense_Mutation_p.G12Y|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAACT	0.347	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(CALU1_LUNG)|G12V(PATU8988S_PANCREAS)|G12C(NCIH1792_LUNG)|G12D(SU8686_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12D(LS513_LARGE_INTESTINE)|G12D(PANC0203_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12C(HCC44_LUNG)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEC50B_ENDOMETRIUM)|G12V(NCIH2444_LUNG)|G12D(MCAS_OVARY)|G12D(ASPC1_PANCREAS)|G12V(SHP77_LUNG)|G12R(CAL62_THYROID)|G12D(HPAFII_PANCREAS)|G12A(NCIH2009_LUNG)|G12D(PANC0403_PANCREAS)|G12C(NCIH2030_LUNG)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(PANC0327_PANCREAS)|G12D(PANC0813_PANCREAS)|G12V(COLO668_LUNG)|G12V(NCIH441_LUNG)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12V(CAPAN2_PANCREAS)|G12R(HUPT3_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12R(HS274T_BREAST)|G12V(SW480_LARGE_INTESTINE)|G12V(QGP1_PANCREAS)|G12S(LS123_LARGE_INTESTINE)|G12C(SW837_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(RKN_OVARY)|G12C(IALM_LUNG)|G12C(UMUC3_URINARY_TRACT)|G12V(RERFLCAD2_LUNG)|G12C(LU99_LUNG)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12V(SH10TC_STOMACH)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12D(COLO678_LARGE_INTESTINE)|G12S(A549_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RERFLCAD1_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH1373_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12C(MIAPACA2_PANCREAS)|G12V(DANG_PANCREAS)|G12D(L33_PANCREAS)|G12C(OV56_OVARY)|G12V(PATU8902_PANCREAS)|G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12R(KP2_PANCREAS)|G12D(SUIT2_PANCREAS)|G12C(NCIH2122_LUNG)|G12D(KP4_PANCREAS)|G12C(NCIH358_LUNG)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12C(SW1463_LARGE_INTESTINE)|G12V(RCM1_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12D(PANC1_PANCREAS)|G12C(SW1573_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	9					0	0	0.004672	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967321	41967321	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:41967321C>A	uc010skn.1	+	10	2211	c.2143C>A	c.(2143-2145)CGT>AGT	p.R715S	PDZRN4_uc001rmq.3_Missense_Mutation_p.R656S|PDZRN4_uc009zjz.2_Missense_Mutation_p.R654S|PDZRN4_uc001rmr.2_Missense_Mutation_p.R541S	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	914							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CCTGAAGGAACGTGCCTTAAA	0.512			NA											24	48					3.08376e-08	4.41572e-08	0.00333	1	0
TMTC3	160418	broad.mit.edu	37	12	88548080	88548081	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:88548080_88548081GG>TT	uc001tau.2	+	4	644_645	c.424_425GG>TT	c.(424-426)GGA>TTA	p.G142L	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	142	Helical; (Potential).					integral to membrane	binding			skin(1)	1						AGGAGTTGTTGGAAGAGCAGAA	0.297			NA											16	21					0	0	0.004672	0	0
C12orf63	374467	broad.mit.edu	37	12	97043823	97043823	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:97043823A>T	uc001tet.1	+	2	198	c.120A>T	c.(118-120)AAA>AAT	p.K40N		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	40										skin(6)|ovary(1)	7						ATTTTATGAAAATCTTTTTAT	0.284			NA											15	26					0	0	0.00245	0	0
STAB2	55576	broad.mit.edu	37	12	104033930	104033930	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:104033930G>C	uc001tjw.2	+	9	1122	c.936G>C	c.(934-936)CAG>CAC	p.Q312H		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	312	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGCATTACCAGAATTTCGTAC	0.433			NA											31	52					0	0	0.002096	0	0
STAB2	55576	broad.mit.edu	37	12	104054150	104054150	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:104054150C>A	uc001tjw.2	+	16	1962	c.1776C>A	c.(1774-1776)GTC>GTA	p.V592V		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	592	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACCACATTGTCCCATTTACCC	0.423			NA											76	171					4.78148e-37	9.59443e-37	0.00361	1	0
BTBD11	121551	broad.mit.edu	37	12	107937911	107937911	+	Silent	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:107937911G>C	uc001tmk.1	+	3	2006	c.1485G>C	c.(1483-1485)GTG>GTC	p.V495V	BTBD11_uc009zut.1_Silent_p.V495V|BTBD11_uc001tmj.2_Silent_p.V495V	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	495						integral to membrane	DNA binding			skin(2)|ovary(1)	3						ACCTCCAGGTGGAAAGGTAAG	0.567			NA											13	20					0	0	0.001855	0	0
RPL6	6128	broad.mit.edu	37	12	112843710	112843710	+	Missense_Mutation	SNP	T	T	G	rs148929822	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:112843710T>G	uc001ttu.2	-	6	890	c.661A>C	c.(661-663)AAG>CAG	p.K221Q	RPL6_uc001ttv.2_Missense_Mutation_p.K221Q	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	221					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1						TTCCGCAGCTTCTTCTTCTTG	0.423			NA											14	37					0	0	0.00245	0	0
TBX5	6910	broad.mit.edu	37	12	114793477	114793477	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:114793477G>T	uc001tvo.2	-	9	1912	c.1417C>A	c.(1417-1419)CAG>AAG	p.Q473K	TBX5_uc001tvp.2_Missense_Mutation_p.Q473K|TBX5_uc001tvq.2_Missense_Mutation_p.Q423K	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	473					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AGGCCAGTCTGAGGCCCACAC	0.627	NSCLC(152;1358 1980 4050 23898 40356)		NA											12	41					1.61879e-10	2.49359e-10	0.001368	1	0
CCDC62	84660	broad.mit.edu	37	12	123270367	123270367	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:123270367G>T	uc001udc.2	+	4	643	c.498G>T	c.(496-498)AAG>AAT	p.K166N	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.K166N|CCDC62_uc001ude.2_Intron	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	166						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		TAAAGCTAAAGGTAATCAAAA	0.408			NA											25	47					7.87624e-14	1.28463e-13	0.00278	1	0
FZD10	11211	broad.mit.edu	37	12	130649097	130649097	+	Missense_Mutation	SNP	G	G	T	rs138051070		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:130649097G>T	uc001uii.2	+	1	2066	c.1610G>T	c.(1609-1611)CGT>CTT	p.R537L	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	537	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GTGTGCAGCCGTAGGTTAAAG	0.537			NA											15	31					4.93089e-13	7.95726e-13	0.00245	1	0
SACS	26278	broad.mit.edu	37	13	23914963	23914963	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr13:23914963C>G	uc001uon.2	-	10	3641	c.3052G>C	c.(3052-3054)GAG>CAG	p.E1018Q	SACS_uc001uoo.2_Missense_Mutation_p.E871Q|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1018					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GATAGATTCTCAAGGACCCAT	0.348			NA											3	70					0	0	0.000248	0	0
FOXO1	2308	broad.mit.edu	37	13	41134854	41134854	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr13:41134854G>A	uc001uxl.3	-	2	1159	c.774C>T	c.(772-774)GAC>GAT	p.D258D	FOXO1_uc010acc.1_Silent_p.D73D	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	258					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TACTGTTGTTGTCCATGGATG	0.522			NA											48	27					0	0	0.00361	0	0
STXBP6	29091	broad.mit.edu	37	14	25326295	25326295	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:25326295C>A	uc001wpu.2	-	3	938	c.223G>T	c.(223-225)GTT>TTT	p.V75F	STXBP6_uc001wpv.2_Missense_Mutation_p.V75F|STXBP6_uc001wpw.2_Missense_Mutation_p.V75F|STXBP6_uc001wpx.1_RNA	NM_014178	NP_054897	Q8NFX7	STXB6_HUMAN	amisyn	75					vesicle-mediated transport	cytoplasm|integral to membrane					0				GBM - Glioblastoma multiforme(265;0.0296)		GATCTCCGAACAAATGATGTG	0.463			NA											45	78					9.84934e-19	1.73644e-18	0.002522	1	0
SLC8A3	6547	broad.mit.edu	37	14	70633417	70633417	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:70633417C>A	uc001xly.2	-	2	2477	c.1723G>T	c.(1723-1725)GGT>TGT	p.G575C	SLC8A3_uc001xlw.2_Missense_Mutation_p.G575C|SLC8A3_uc001xlx.2_Missense_Mutation_p.G575C|SLC8A3_uc001xlz.2_Missense_Mutation_p.G575C|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	575	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCACCGCCACCCTTGGCTGTC	0.512			NA											28	48					4.59853e-10	6.94332e-10	0.005443	1	0
TTC8	123016	broad.mit.edu	37	14	89341421	89341421	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:89341421C>T	uc010ath.2	+	14	1581	c.1447C>T	c.(1447-1449)CCG>TCG	p.P483S	TTC8_uc001xxl.2_Missense_Mutation_p.P228S|TTC8_uc010ati.2_Missense_Mutation_p.P269S|TTC8_uc001xxm.2_Intron|TTC8_uc010atj.2_Missense_Mutation_p.P202S|TTC8_uc001xxi.2_Missense_Mutation_p.P467S|TTC8_uc001xxj.2_Missense_Mutation_p.P457S|TTC8_uc001xxk.2_Missense_Mutation_p.P427S	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	493					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						TATGTATGAACCGCATTTTAA	0.299			NA							Bardet-Biedl_syndrome				21	37					0	0	0.002299	0	0
SLC24A4	123041	broad.mit.edu	37	14	92909770	92909770	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:92909770G>T	uc001yak.2	+	7	582	c.558G>T	c.(556-558)GTG>GTT	p.V186V	SLC24A4_uc001yai.2_Silent_p.V139V|SLC24A4_uc010twm.1_Silent_p.V203V|SLC24A4_uc001yaj.2_Silent_p.V186V|SLC24A4_uc010auj.2_Silent_p.V94V|SLC24A4_uc010twn.1_5'UTR	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	203	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GGTGGGCCGTGTGCCGAGACT	0.657	NSCLC(10;315 435 10383 28450 38798)		NA											29	40					1.88708e-17	3.25175e-17	0.008361	1	0
PGBD4	161779	broad.mit.edu	37	15	34395533	34395533	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:34395533G>A	uc001zho.2	+	1	1260	c.801G>A	c.(799-801)CCG>CCA	p.P267P	C15orf24_uc001zhm.2_5'Flank|C15orf24_uc001zhn.2_5'Flank	NM_152595	NP_689808	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	267											0		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		AGTACCTCCCGACAAAACGAG	0.413			NA											9	16					0	0	0.004482	0	0
DISP2	85455	broad.mit.edu	37	15	40655997	40655997	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:40655997G>A	uc001zlk.1	+	2	380	c.291G>A	c.(289-291)CGG>CGA	p.R97R		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	97					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCTATCCCCGGGCACTGCAGG	0.657			NA											24	34					0	0	0.00278	0	0
Unknown	0	broad.mit.edu	37	15	85787980	85787980	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:85787980T>G	uc010upj.1	+	6	788	c.723T>G	c.(721-723)CAT>CAG	p.H241Q	uc010upk.1_5'Flank	NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like												NA						TACGTGAACATGAGGAGAGGC	0.562			NA											2	2					0	0	0.004672	0	0
OR4F6	390648	broad.mit.edu	37	15	102346553	102346553	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:102346553T>C	uc010utr.1	+	1	631	c.631T>C	c.(631-633)TTT>CTT	p.F211L		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTGGCTTCTTTTTTAATTCT	0.363			NA											40	31					0	0	0.005524	0	0
ADCY9	115	broad.mit.edu	37	16	4164490	4164490	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:4164490C>A	uc002cvx.2	-	2	1493	c.954G>T	c.(952-954)ATG>ATT	p.M318I		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	318	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CCTTCCCGTGCATAATGGATT	0.547			NA											37	40					5.43694e-19	9.64108e-19	0.005524	1	0
USP31	57478	broad.mit.edu	37	16	23080722	23080722	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:23080722C>A	uc002dll.2	-	16	2704	c.2704G>T	c.(2704-2706)GCA>TCA	p.A902S	USP31_uc002dlk.2_Missense_Mutation_p.A174S|USP31_uc010vca.1_Missense_Mutation_p.A205S|USP31_uc010bxm.2_Missense_Mutation_p.A190S	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	902	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		TCATCTGCTGCCTCCCCAATC	0.522			NA											12	24					1.08611e-07	1.50574e-07	0.000978	1	0
KIAA0556	23247	broad.mit.edu	37	16	27789020	27789020	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:27789020C>T	uc002dow.2	+	26	4665	c.4641C>T	c.(4639-4641)ACC>ACT	p.T1547T	KIAA0556_uc010vco.1_Silent_p.T49T	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1547										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GTGAGCCCACCGTGCCCTACC	0.642			NA											8	72					0	0	0.006214	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890646	32890646	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:32890646C>A	uc002edh.1	-	5	416	c.240G>T	c.(238-240)GTG>GTT	p.V80V	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						GCTTGTAGTACACAACGTTGA	0.433			NA											12	23					2.27111e-07	3.09236e-07	0.001368	1	0
NDRG4	65009	broad.mit.edu	37	16	58537784	58537784	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:58537784C>A	uc002eno.2	+	2	210	c.104C>A	c.(103-105)ACC>AAC	p.T35N	NDRG4_uc002enk.2_Missense_Mutation_p.T67N|NDRG4_uc002enm.2_Missense_Mutation_p.T87N|NDRG4_uc010vif.1_Missense_Mutation_p.T67N|NDRG4_uc010cdk.2_Missense_Mutation_p.T35N|NDRG4_uc010vig.1_Missense_Mutation_p.T65N|NDRG4_uc010vih.1_5'UTR|NDRG4_uc010vii.1_Missense_Mutation_p.T53N|NDRG4_uc002enp.2_Missense_Mutation_p.T35N|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	35					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						GCCATCCTCACCTACCATGAT	0.637			NA											18	28					0.000132079	0.000170695	0.008871	1	0
CHST4	10164	broad.mit.edu	37	16	71571481	71571481	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:71571481C>T	uc002fan.2	+	2	1082	c.901C>T	c.(901-903)CAT>TAT	p.H301Y	CHST4_uc002fao.2_Missense_Mutation_p.H301Y	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	301	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						ATTCTTGCCCCATCTTCAGAC	0.562			NA									OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	34					0	0	0.004007	0	0
TUBB3	10381	broad.mit.edu	37	16	89985766	89985766	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:89985766C>T	uc002fpf.2	+	1	508	c.100C>T	c.(100-102)CGG>TGG	p.R34W	MC1R_uc002fpe.3_Missense_Mutation_p.R34W|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GACAGGAGCCCGGTGCCTGGA	0.647			NA											3	27					0	0	0.004672	0	0
TP53	7157	broad.mit.edu	37	17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:7578455C>G	uc002gim.2	-	5	669	c.475G>C	c.(475-477)GCC>CCC	p.A159P	TP53_uc002gig.1_Missense_Mutation_p.A159P|TP53_uc002gih.2_Missense_Mutation_p.A159P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27P|TP53_uc010cng.1_Missense_Mutation_p.A27P|TP53_uc002gii.1_Missense_Mutation_p.A27P|TP53_uc010cnh.1_Missense_Mutation_p.A159P|TP53_uc010cni.1_Missense_Mutation_p.A159P|TP53_uc002gij.2_Missense_Mutation_p.A159P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66P|TP53_uc002gio.2_Missense_Mutation_p.A27P|TP53_uc010vug.1_Missense_Mutation_p.A120P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R158fs*11(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	14					0	0	0.003954	0	0
MRM1	79922	broad.mit.edu	37	17	34958541	34958541	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:34958541G>A	uc002hne.2	+	1	517	c.302G>A	c.(301-303)CGG>CAG	p.R101Q	MRM1_uc002hnf.2_5'UTR	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	101					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCAGTTCTGCGGCCCAGACGG	0.687			NA											24	29					0	0	0.003954	0	0
C17orf57	124989	broad.mit.edu	37	17	45473278	45473278	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:45473278C>G	uc002iln.2	+	17	2291	c.1880C>G	c.(1879-1881)TCT>TGT	p.S627C	C17orf57_uc002ilm.2_Missense_Mutation_p.S531C	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	627							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						AATACTCTGTCTAGTTTGAAT	0.353			NA											4	58					0	0	0.000248	0	0
TEX14	56155	broad.mit.edu	37	17	56676480	56676480	+	Silent	SNP	G	G	A	rs114600472	by1000genomes	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:56676480G>A	uc010dcz.1	-	14	2362	c.2244C>T	c.(2242-2244)CAC>CAT	p.H748H	TEX14_uc002iwr.1_Silent_p.H742H|TEX14_uc002iws.1_Silent_p.H742H|TEX14_uc010dda.1_Silent_p.H522H	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	748	Potential.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CATCATTCTCGTGCATTATTG	0.428			NA											53	134					0	0	0.00361	0	0
TEX14	56155	broad.mit.edu	37	17	56700349	56700349	+	Silent	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:56700349A>T	uc010dcz.1	-	4	394	c.276T>A	c.(274-276)CCT>CCA	p.P92P	TEX14_uc002iwr.1_Silent_p.P92P|TEX14_uc002iws.1_Silent_p.P92P|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	92	ANK 3.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCATGGACAGGGGTGCTCC	0.567			NA											13	38					0	0	0.001368	0	0
RNMT	8731	broad.mit.edu	37	18	13737099	13737099	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:13737099G>A	uc002ksk.1	+	4	711	c.644G>A	c.(643-645)TGG>TAG	p.W215*	RNMT_uc002ksl.1_Nonsense_Mutation_p.W215*|RNMT_uc002ksm.1_Nonsense_Mutation_p.W215*|RNMT_uc010dlk.2_Nonsense_Mutation_p.W215*|RNMT_uc010xae.1_RNA	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	215					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						TTGCTGAAATGGAAAAAAGGA	0.328	GBM(29;474 594 19092 36647 41529)		NA											13	22					0	0	0.003163	0	0
MC5R	4161	broad.mit.edu	37	18	13826520	13826520	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:13826520C>A	uc010xaf.1	+	1	756	c.756C>A	c.(754-756)GCC>GCA	p.A252A		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	252	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTGCTGGGCCCCGTTCTTCC	0.572			NA											26	94					9.57634e-11	1.4902e-10	0.00333	1	0
ALPK2	115701	broad.mit.edu	37	18	56274588	56274588	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:56274588C>G	uc002lhj.3	-	3	407	c.193G>C	c.(193-195)GAG>CAG	p.E65Q		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	65	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TACTGATTCTCAAAGAATTCA	0.393			NA											3	44					0	0	0.004672	0	0
ACSBG2	81616	broad.mit.edu	37	19	6187335	6187335	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:6187335C>A	uc002mef.1	+	12	1809	c.1582C>A	c.(1582-1584)CCT>ACT	p.P528T	ACSBG2_uc002mee.1_Missense_Mutation_p.P341T|ACSBG2_uc002meg.1_Missense_Mutation_p.P528T|ACSBG2_uc002meh.1_Missense_Mutation_p.P528T|ACSBG2_uc002mei.1_Missense_Mutation_p.P478T|ACSBG2_uc010xiz.1_Missense_Mutation_p.P528T	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	528					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						GCCCCCCATTCCTGTTGAGAC	0.468			NA											56	25					5.86059e-21	1.08332e-20	0.00361	1	0
MAP2K7	5609	broad.mit.edu	37	19	7975916	7975916	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:7975916G>T	uc002mit.2	+	7	792	c.727G>T	c.(727-729)GAC>TAC	p.D243Y	MAP2K7_uc002miv.2_Missense_Mutation_p.D243Y|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.D243Y|MAP2K7_uc010dvv.2_Missense_Mutation_p.D118Y	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	243	Protein kinase.	Proton acceptor (By similarity).			activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	CATCCACCGCGACGTCAAGCC	0.632			NA											20	10					2.4624e-09	3.66357e-09	0.008871	1	0
MUC16	94025	broad.mit.edu	37	19	9065219	9065219	+	Silent	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:9065219G>C	uc002mkp.2	-	3	22431	c.22227C>G	c.(22225-22227)TCC>TCG	p.S7409S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7411	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGTAATGTGGAAGAAACAG	0.522			NA											3	31					0	0	0.000248	0	0
MUC16	94025	broad.mit.edu	37	19	9087031	9087031	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:9087031G>T	uc002mkp.2	-	1	4988	c.4784C>A	c.(4783-4785)ACA>AAA	p.T1595K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1595	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCCCTTGTGTCCCGAGCTC	0.483			NA											67	39					1.08241e-25	2.10276e-25	0.00361	1	0
EMR2	30817	broad.mit.edu	37	19	14865885	14865885	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:14865885C>A	uc002mzp.1	-	14	1927	c.1471G>T	c.(1471-1473)GGA>TGA	p.G491*	EMR2_uc010dzs.1_Intron|EMR2_uc010xnw.1_Intron|EMR2_uc002mzo.1_Nonsense_Mutation_p.G480*|EMR2_uc002mzq.1_Nonsense_Mutation_p.G431*|EMR2_uc002mzr.1_Nonsense_Mutation_p.G442*|EMR2_uc002mzs.1_Nonsense_Mutation_p.G349*|EMR2_uc002mzt.1_Nonsense_Mutation_p.G387*|EMR2_uc002mzu.1_Nonsense_Mutation_p.G398*|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_Intron	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	491	Extracellular (Potential).|GPS.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						TGACCACATCCATTCTGGCCA	0.512			NA											36	16					2.05212e-20	3.74788e-20	0.005524	1	0
ZNF85	7639	broad.mit.edu	37	19	21131729	21131729	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:21131729T>C	uc002npg.3	+	4	536	c.409T>C	c.(409-411)TGT>CGT	p.C137R	ZNF85_uc010ecn.2_Missense_Mutation_p.C72R|ZNF85_uc010eco.2_Missense_Mutation_p.C85R|ZNF85_uc002npi.2_Missense_Mutation_p.C78R	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	137						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						ACTTAACCAATGTCTCACAGC	0.323			NA											11	46					0	0	0.000978	0	0
FCGBP	8857	broad.mit.edu	37	19	40367787	40367787	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:40367787G>A	uc002omp.3	-	29	13181	c.13173C>T	c.(13171-13173)TGC>TGT	p.C4391C		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4391	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AACCCGCGTCGCACTGGCAGC	0.647			NA											19	56					0	0	0.003954	0	0
TRPM4	54795	broad.mit.edu	37	19	49675355	49675355	+	Silent	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:49675355C>G	uc002pmw.2	+	9	1212	c.1140C>G	c.(1138-1140)GCC>GCG	p.A380A	TRPM4_uc010emu.2_Silent_p.A380A|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Silent_p.A206A|TRPM4_uc010emv.2_Silent_p.A265A|TRPM4_uc010yal.1_Intron	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	380	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TTTTGAAGGCCCTTGTGAAGG	0.502			NA											28	43					0	0	0.007291	0	0
ZNF534	147658	broad.mit.edu	37	19	52942343	52942343	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:52942343C>G	uc002pzk.2	+	4	1730	c.1669C>G	c.(1669-1671)CAT>GAT	p.H557D	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.H544D	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	557	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGAATGTTCATACTGGAGA	0.438			NA											5	1					0	0	0.001168	0	0
ZNF816A	125893	broad.mit.edu	37	19	53454526	53454526	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:53454526G>A	uc002qal.1	-	5	803	c.502C>T	c.(502-504)CAC>TAC	p.H168Y	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.H152Y	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TGAAACATGTGGAGTTCAGGC	0.423			NA											30	110					0	0	0.008361	0	0
KIR3DP1	768329	broad.mit.edu	37	19	55301604	55301605	+	Missense_Mutation	DNP	TC	TC	CA			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:55301604_55301605TC>CA	uc010yfi.1	+	5	784_785	c.783_784TC>CA	c.(781-786)GCTCAT>GCCAAT	p.H262N	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Intron	NM_001015070	NP_001015070			killer-cell Ig-like receptor												0				GBM - Glioblastoma multiforme(193;0.0192)		AGGGGGAGGCTCATGAACTTAG	0.599			NA											23	61					0	0	0.004672	0	0
STRN	6801	broad.mit.edu	37	2	37132762	37132762	+	Splice_Site	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:37132762C>A	uc002rpn.2	-	4	422	c.413_splice	c.e4-1	p.D138_splice	STRN_uc010ezx.2_Splice_Site_p.D138_splice	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein						dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTACCTTCATCTAGAAAACAT	0.333			NA											11	48					2.80697e-09	4.15596e-09	0.000978	1	0
SIX2	10736	broad.mit.edu	37	2	45233362	45233362	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:45233362G>T	uc002ruo.2	-	2	1116	c.823C>A	c.(823-825)CAG>AAG	p.Q275K	SIX2_uc002rup.2_Missense_Mutation_p.Q277K	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	275						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATGGAGTCCTGCAGGCCATGG	0.642			NA											9	80					2.52707e-12	4.01435e-12	0.006214	1	0
C2orf86	51057	broad.mit.edu	37	2	63631787	63631787	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:63631787C>A	uc002sch.2	-	10	1277	c.831G>T	c.(829-831)CTG>CTT	p.L277L	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Silent_p.L118L|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Silent_p.L85L|C2orf86_uc002sci.1_Silent_p.L253L|C2orf86_uc010fcr.1_Silent_p.L167L	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	277					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						GGACAGAACTCAGAACCTGTT	0.408			NA											19	39					3.99206e-14	6.54612e-14	0.007413	1	0
DYSF	8291	broad.mit.edu	37	2	71783149	71783149	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:71783149G>T	uc002sie.2	+	22	2486	c.2110G>T	c.(2110-2112)GAC>TAC	p.D704Y	DYSF_uc010feg.2_Missense_Mutation_p.D735Y|DYSF_uc010feh.2_Missense_Mutation_p.D690Y|DYSF_uc002sig.3_Missense_Mutation_p.D690Y|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D704Y|DYSF_uc010fef.2_Missense_Mutation_p.D721Y|DYSF_uc010fei.2_Missense_Mutation_p.D721Y|DYSF_uc010fek.2_Missense_Mutation_p.D722Y|DYSF_uc010fej.2_Missense_Mutation_p.D691Y|DYSF_uc010fel.2_Missense_Mutation_p.D691Y|DYSF_uc010feo.2_Missense_Mutation_p.D736Y|DYSF_uc010fem.2_Missense_Mutation_p.D705Y|DYSF_uc010fen.2_Missense_Mutation_p.D722Y|DYSF_uc002sif.2_Missense_Mutation_p.D705Y	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	704	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTCCACGGAGGACGTGGACTC	0.662			NA											3	6					0.004672	0.00572273	0.004672	1	0
GGCX	2677	broad.mit.edu	37	2	85777724	85777724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:85777724G>A	uc002sps.2	-	14	2144	c.2038C>T	c.(2038-2040)CGA>TGA	p.R680*	GGCX_uc010yss.1_Nonsense_Mutation_p.R496*|GGCX_uc010yst.1_Nonsense_Mutation_p.R623*	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	680	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CGGAAGAATCGCTCATGGAAA	0.483			NA											47	62					0	0	0.003214	0	0
GLI2	2736	broad.mit.edu	37	2	121726325	121726325	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:121726325C>A	uc010flp.2	+	5	709	c.679C>A	c.(679-681)CTG>ATG	p.L227M	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.P97H|GLI2_uc010flo.1_Missense_Mutation_p.L102M|GLI2_uc002tmw.1_Missense_Mutation_p.L227M	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	227					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GACGCCCCGCCTGAGCCGCAA	0.642			NA											22	79					7.33532e-06	9.76975e-06	0.003954	1	0
POTEF	728378	broad.mit.edu	37	2	130877604	130877604	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:130877604C>A	uc010fmh.2	-	3	885	c.485G>T	c.(484-486)AGG>ATG	p.R162M		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	162						cell cortex	ATP binding			skin(3)|ovary(2)	5						GTCAGTGTCCCTGAGCATGAC	0.587			NA											30	21					6.84511e-11	1.07065e-10	0.003271	1	0
LRP1B	53353	broad.mit.edu	37	2	141108413	141108413	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:141108413T>C	uc002tvj.1	-	77	12817	c.11845A>G	c.(11845-11847)AAA>GAA	p.K3949E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3949	Extracellular (Potential).|LDL-receptor class B 33.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGATCCTTTTGTAGAAAATT	0.348	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	19					0	0	0.006214	0	0
LRP1B	53353	broad.mit.edu	37	2	141108467	141108467	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:141108467G>C	uc002tvj.1	-	77	12763	c.11791C>G	c.(11791-11793)CAA>GAA	p.Q3931E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3931	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATCTCTTTGATAATATACA	0.348	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			10	37					0	0	0.006214	0	0
RIF1	55183	broad.mit.edu	37	2	152267818	152267818	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:152267818A>T	uc002txm.2	+	3	279	c.149A>T	c.(148-150)GAG>GTG	p.E50V	RIF1_uc002txl.2_Missense_Mutation_p.E50V|RIF1_uc010fnv.1_Missense_Mutation_p.E14V|RIF1_uc002txn.2_Missense_Mutation_p.E50V|RIF1_uc002txo.2_Missense_Mutation_p.E50V|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	50					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ACAGAAATTGAGAAAAAACTT	0.284			NA											15	25					0	0	0.004007	0	0
GRB14	2888	broad.mit.edu	37	2	165353575	165353575	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:165353575T>C	uc002ucl.2	-	12	1866	c.1325A>G	c.(1324-1326)CAC>CGC	p.H442R	GRB14_uc010zcv.1_Missense_Mutation_p.H355R|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	442	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						AGAAATTTTGTGGTGAAACCA	0.388			NA											6	29					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179425863	179425863	+	Silent	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:179425863A>G	uc010zfg.1	-	275	77516	c.77292T>C	c.(77290-77292)GCT>GCC	p.A25764A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A19459A|TTN_uc010zfi.1_Silent_p.A19392A|TTN_uc010zfj.1_Silent_p.A19267A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26691							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGTCAGCAGCATTCCTTG	0.403			NA											22	64					0	0	0.001882	0	0
TTN	7273	broad.mit.edu	37	2	179542483	179542483	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:179542483G>A	uc010zfg.1	-	143	30648	c.30424C>T	c.(30424-30426)CCT>TCT	p.P10142S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6803S|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11069							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCTTCAGGTAGAACTTCC	0.428			NA											22	81					0	0	0.00278	0	0
PTPRN	5798	broad.mit.edu	37	2	220161970	220161970	+	Silent	SNP	C	C	A	rs145338513	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:220161970C>A	uc002vkz.2	-	14	2162	c.2073G>T	c.(2071-2073)ACG>ACT	p.T691T	PTPRN_uc010zlc.1_Silent_p.T601T|PTPRN_uc002vla.2_Silent_p.T662T	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	691	Cytoplasmic (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCATGTGTCCCGTGGAGATGT	0.662			NA											22	27					1.28384e-07	1.77181e-07	0.001882	1	0
USP40	55230	broad.mit.edu	37	2	234436148	234436148	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:234436148C>A	uc010zmr.1	-	12	1663	c.1663G>T	c.(1663-1665)GCT>TCT	p.A555S	USP40_uc010zmt.1_Missense_Mutation_p.A199S	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	543					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		GGGTGCAGAGCCCCATTGAAG	0.403			NA											15	15					1.67942e-08	2.43915e-08	0.006122	1	0
COL6A3	1293	broad.mit.edu	37	2	238250709	238250709	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:238250709C>T	uc002vwl.2	-	37	8049	c.7764G>A	c.(7762-7764)TTG>TTA	p.L2588L	COL6A3_uc002vwo.2_Silent_p.L2382L|COL6A3_uc010znj.1_Silent_p.L1981L|COL6A3_uc002vwj.2_5'UTR	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2588	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAGCTTACCCAAGCAAACAT	0.463			NA											5	21					0	0	0.000602	0	0
PROKR2	128674	broad.mit.edu	37	20	5294591	5294591	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:5294591G>T	uc010zqw.1	-	1	425	c.425C>A	c.(424-426)TCC>TAC	p.S142Y	PROKR2_uc010zqx.1_Missense_Mutation_p.S142Y|PROKR2_uc010zqy.1_Missense_Mutation_p.S142Y|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	142	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCATTGGTGGAGACGTAGAG	0.597			NA								HNSCC(71;0.22)			17	13					1.5739e-10	2.43674e-10	0.004007	1	0
ASXL1	171023	broad.mit.edu	37	20	31022609	31022609	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:31022609G>T	uc002wxs.2	+	12	2520	c.2094G>T	c.(2092-2094)CCG>CCT	p.P698P	ASXL1_uc010geb.2_Silent_p.P589P	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	698					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						AACTACTGCCGCCTTATCCTC	0.587			NA	F|N|Mis		MDS|CMML								6	17					0.00448238	0.00551261	0.004482	1	0
SPATA2	9825	broad.mit.edu	37	20	48522689	48522689	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:48522689T>A	uc010gie.2	-	3	1380	c.1030A>T	c.(1030-1032)AGG>TGG	p.R344W	SPATA2_uc002xuw.2_Missense_Mutation_p.R344W|SPATA2_uc010zyn.1_Missense_Mutation_p.R207W	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	344					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TAGGTGGCCCTGGGTTCAGAG	0.637			NA											24	25					0	0	0.00278	0	0
TTC3	7267	broad.mit.edu	37	21	38538740	38538740	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr21:38538740G>T	uc002yvz.2	+	33	4329	c.4224G>T	c.(4222-4224)GAG>GAT	p.E1408D	TTC3_uc011aee.1_Missense_Mutation_p.E1098D|TTC3_uc002ywa.2_Missense_Mutation_p.E1408D|TTC3_uc002ywb.2_Missense_Mutation_p.E1408D|TTC3_uc010gnf.2_Missense_Mutation_p.E1173D|TTC3_uc002ywc.2_Missense_Mutation_p.E1098D|TTC3_uc002ywd.1_Missense_Mutation_p.E472D	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1408					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AGATCCTTGAGGGCTCTTTGG	0.438	Ovarian(38;194 1649 35661)		NA											37	39					1.22674e-20	2.25396e-20	0.00874	1	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											3	6					0	0	0.004672	0	0
C22orf42	150297	broad.mit.edu	37	22	32546391	32546391	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:32546391A>G	uc003amd.2	-	7	610	c.569T>C	c.(568-570)CTA>CCA	p.L190P		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	190										ovary(1)|skin(1)	2						AGAGACAGATAGGCTTTCACT	0.438			NA											39	39					0	0	0.00623	0	0
GCAT	23464	broad.mit.edu	37	22	38211724	38211724	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:38211724G>C	uc003atz.2	+	7	889	c.869G>C	c.(868-870)CGG>CCG	p.R290P	GCAT_uc003aua.1_Missense_Mutation_p.R316P	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	290					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGCGCGCCCGGCCATACCTC	0.642			NA											49	67					0	0	0.00361	0	0
CPT1B	1375	broad.mit.edu	37	22	51015406	51015406	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:51015406G>A	uc003bmk.3	-	3	501	c.339C>T	c.(337-339)TCC>TCT	p.S113S	CPT1B_uc003bml.2_Silent_p.S113S|CPT1B_uc003bmm.2_Silent_p.S113S|CPT1B_uc003bmo.2_Silent_p.S113S|CPT1B_uc011asa.1_Silent_p.S113S|CPT1B_uc003bmn.2_Silent_p.S113S|CPT1B_uc011asb.1_Silent_p.S113S|CHKB-CPT1B_uc003bmp.2_5'UTR	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	113	Helical; (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		AGACGCCCGTGGAGAAGATGG	0.607	Esophageal Squamous(170;988 1933 25577 30295 48163)		NA									OREG0026685	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	55					0	0	0.00361	0	0
CMTM7	112616	broad.mit.edu	37	3	32495741	32495741	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:32495741G>T	uc003cey.1	+	5	759	c.523G>T	c.(523-525)GTC>TTC	p.V175F	CMTM7_uc003cez.1_Missense_Mutation_p.V142F	NM_138410	NP_612419	Q96FZ5	CKLF7_HUMAN	CKLF-like MARVEL transmembrane domain containing	175					chemotaxis	extracellular space|integral to membrane	cytokine activity				0						AGATGCAGCCGTCTGATGAGG	0.587			NA											16	41					5.3912e-06	7.21192e-06	0.006122	1	0
NKTR	4820	broad.mit.edu	37	3	42685392	42685392	+	Splice_Site	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:42685392A>T	uc003clo.2	+	16	4347	c.4200_splice	c.e16-2	p.R1400_splice	NKTR_uc003clp.2_Missense_Mutation_p.R1148W|NKTR_uc011azp.1_Silent_p.A210A|NKTR_uc003cls.2_Splice_Site_p.R1100_splice	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence						protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CCGTTAAAGCAGGTCCTACAC	0.443			NA											12	18					0	0	0.001368	0	0
DUSP7	1849	broad.mit.edu	37	3	52088311	52088311	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:52088311C>A	uc003dct.2	-	2	676	c.597G>T	c.(595-597)TCG>TCT	p.S199S	DUSP7_uc010hma.2_Silent_p.S199S	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	199	Ser-rich.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGGTGGGTGGCGAGCTGCTCG	0.627			NA											13	42					1.49906e-05	1.97928e-05	0.00245	1	0
CNTN3	5067	broad.mit.edu	37	3	74316416	74316416	+	Splice_Site	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:74316416C>T	uc003dpm.1	-	20	2897	c.2817_splice	c.e20+1	p.K939_splice		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AGAAAACTTACTTTATATCCT	0.338			NA											9	53					0	0	0.004482	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101574687	101574687	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:101574687A>G	uc003dvp.2	+	9	1880	c.1765A>G	c.(1765-1767)AAG>GAG	p.K589E	NFKBIZ_uc003dvo.2_Missense_Mutation_p.K489E|NFKBIZ_uc010hpo.2_Missense_Mutation_p.K489E|NFKBIZ_uc003dvq.2_Missense_Mutation_p.K467E	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	589	Interaction with NFKB1/p50 (By similarity).|ANK 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						ACTGAAGAATAAGAGTCTGGT	0.448			NA											13	25					0	0	0.001368	0	0
COL29A1	256076	broad.mit.edu	37	3	130159301	130159301	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:130159301T>A	uc010htj.1	+	35	6613	c.6119T>A	c.(6118-6120)CTA>CAA	p.L2040Q	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.L79Q	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2040	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						AACCAACTCCTAATGAAGAAT	0.408			NA											14	67					0	0	0.003163	0	0
PIK3CB	5291	broad.mit.edu	37	3	138456718	138456718	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:138456718C>A	uc011bmq.1	-	4	632	c.632G>T	c.(631-633)AGC>ATC	p.S211I		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	211	PI3K-RBD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CACTTGAAAGCTAAACACGTC	0.348			NA											6	26					8.12818e-05	0.000105944	0.001984	1	0
TM4SF4	7104	broad.mit.edu	37	3	149193609	149193609	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:149193609G>T	uc003exd.1	+	2	406	c.175_splice	c.e2-1	p.M59_splice		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4							integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TCTCCTGGTAGATGATCTTCC	0.572			NA											7	15					2.7689e-08	3.98355e-08	0.001984	1	0
SI	6476	broad.mit.edu	37	3	164727105	164727105	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:164727105A>G	uc003fei.2	-	35	4203	c.4141T>C	c.(4141-4143)TTT>CTT	p.F1381L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1381	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCATTGTAAAAGTCCACAATT	0.368			NA								HNSCC(35;0.089)			3	62					0	0	0.004672	0	0
MFSD7	84179	broad.mit.edu	37	4	678304	678304	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:678304C>A	uc003gay.2	-	6	868	c.811G>T	c.(811-813)GAG>TAG	p.E271*	MFSD7_uc003gaw.2_Nonsense_Mutation_p.E13*|MFSD7_uc003gax.2_Nonsense_Mutation_p.E270*|MFSD7_uc003gaz.2_Nonsense_Mutation_p.E152*|MFSD7_uc003gba.2_Nonsense_Mutation_p.E174*|MFSD7_uc003gbb.1_Nonsense_Mutation_p.E206*	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	271					transmembrane transport	integral to membrane					0						AGGATCTGCTCCAGGAGGGCT	0.622			NA									OREG0016025	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	63					9.90819e-18	1.71704e-17	0.00361	1	0
OTOP1	133060	broad.mit.edu	37	4	4214688	4214688	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:4214688G>T	uc003ghp.1	-	2	477	c.447C>A	c.(445-447)TGC>TGA	p.C149*		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	149	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CAATTTTAAGGCATCCCAGGA	0.408			NA											6	16					3.59834e-05	4.73057e-05	0.001168	1	0
C4orf14	84273	broad.mit.edu	37	4	57843074	57843074	+	Silent	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:57843074C>G	uc003hck.2	-	1	753	c.678G>C	c.(676-678)CTG>CTC	p.L226L	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	226							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GGGCGTCGGGCAGGTCCAGCA	0.697			NA											14	49					0	0	0.001855	0	0
C4orf35	85438	broad.mit.edu	37	4	71201618	71201618	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:71201618G>T	uc003hff.2	+	1	948	c.862G>T	c.(862-864)GAT>TAT	p.D288Y		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	288						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				TCTGCTAACTGATGAAGAAAC	0.413			NA											8	25					9.70103e-10	1.4504e-09	0.008291	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73148902	73148902	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:73148902T>G	uc003hgk.1	-	22	3606	c.3569A>C	c.(3568-3570)AAG>ACG	p.K1190T		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1190					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCAATGATCTTTCCATCTTT	0.448	NSCLC(168;1941 2048 2918 13048 43078)		NA											11	77					0	0	0.001368	0	0
USO1	8615	broad.mit.edu	37	4	76725312	76725312	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:76725312A>T	uc003hiu.2	+	17	2187	c.2012A>T	c.(2011-2013)CAG>CTG	p.Q671L	USO1_uc003hiv.2_Missense_Mutation_p.Q513L|USO1_uc003hiw.2_Missense_Mutation_p.Q506L	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	671	Potential.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GAATTAAGGCAGCAGGTTTCT	0.368			NA											10	8					0	0	0.006214	0	0
NEUROG2	63973	broad.mit.edu	37	4	113436575	113436575	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:113436575C>A	uc003ias.2	-	2	384	c.57G>T	c.(55-57)CTG>CTT	p.L19L		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	19					positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		CCGATCCGAGCAGCACTAACA	0.483			NA											9	33					3.09899e-07	4.20085e-07	0.004482	1	0
MMAA	166785	broad.mit.edu	37	4	146560343	146560343	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:146560343A>G	uc003ikh.3	+	2	137	c.52A>G	c.(52-54)AGA>GGA	p.R18G	MMAA_uc003ikg.2_Missense_Mutation_p.R18G|MMAA_uc003iki.1_RNA|MMAA_uc010iow.2_RNA	NM_172250	NP_758454	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria type A precursor	18						mitochondrion	GTP binding|nucleoside-triphosphatase activity			ovary(1)	1	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGCCTTTTAAGAGCACCTTT	0.438			NA											22	70					0	0	0.001882	0	0
TLR2	7097	broad.mit.edu	37	4	154625452	154625452	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:154625452A>T	uc003inq.2	+	3	1612	c.1393A>T	c.(1393-1395)AGC>TGC	p.S465C	TLR2_uc003inr.2_Missense_Mutation_p.S465C|TLR2_uc003ins.2_Missense_Mutation_p.S465C	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	465	LRR 12.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				TTTAGATGTTAGCAACAACAA	0.368			NA											34	27					0	0	0.003271	0	0
GALNTL6	442117	broad.mit.edu	37	4	173942643	173942643	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:173942643G>A	uc003isv.2	+	12	2241	c.1505G>A	c.(1504-1506)TGG>TAG	p.W502*		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	502	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.?(1)		breast(2)|ovary(1)|skin(1)	4						ACCTTTGGATGGAGAGAAGAT	0.478			NA											31	43					0	0	0.002836	0	0
MLF1IP	79682	broad.mit.edu	37	4	185622019	185622019	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:185622019T>A	uc003iwq.2	-	11	1011	c.941A>T	c.(940-942)GAA>GTA	p.E314V	MLF1IP_uc003iwp.2_Intron|MLF1IP_uc003iwr.1_Intron	NM_024629	NP_078905	Q71F23	CENPU_HUMAN	MLF1 interacting protein	314	Nuclear localization signal (Potential).|Potential.				CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm					0		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		CCTTTTCTTTTCGATATCTGA	0.323			NA											19	47					0	0	0.002299	0	0
CDH12	1010	broad.mit.edu	37	5	22078729	22078729	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:22078729G>A	uc010iuc.2	-	2	515	c.57C>T	c.(55-57)CTC>CTT	p.L19L	CDH12_uc011cno.1_Silent_p.L19L|CDH12_uc003jgk.2_Silent_p.L19L	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	19					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GTGGTGTTAGGAGACCTCCAT	0.453			NA								HNSCC(59;0.17)			33	225					0	0	0.002445	0	0
CDH10	1008	broad.mit.edu	37	5	24498613	24498613	+	Missense_Mutation	SNP	G	G	A	rs145457868	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:24498613G>A	uc003jgr.1	-	9	1741	c.1409C>T	c.(1408-1410)ACA>ATA	p.T470I	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	470	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CACGCGTGTTGTCTCTTTGGG	0.373			NA								HNSCC(23;0.051)			35	24					0	0	0.004289	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576368	33576368	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:33576368G>T	uc003jia.1	-	19	3926	c.3763C>A	c.(3763-3765)CAC>AAC	p.H1255N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.H1170N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1255	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTGGCTGGTGGTCTCCTCCC	0.527			NA								HNSCC(64;0.19)			83	85					9.46827e-25	1.82774e-24	0.00361	1	0
NNT	23530	broad.mit.edu	37	5	43700243	43700243	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:43700243G>T	uc003joe.2	+	20	3154	c.2899G>T	c.(2899-2901)GGC>TGC	p.G967C	NNT_uc003jof.2_Missense_Mutation_p.G967C	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	967	Mitochondrial matrix.|NADP.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	CCCAGTTGCAGGCCGAATGCC	0.458			NA											24	110					1.17739e-12	1.88013e-12	0.005443	1	0
SLC38A9	153129	broad.mit.edu	37	5	54968503	54968503	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:54968503G>C	uc003jqf.2	-	4	335	c.134C>G	c.(133-135)ACA>AGA	p.T45R	SLC38A9_uc003jqd.2_5'UTR|SLC38A9_uc010ivx.2_Missense_Mutation_p.T18R|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Intron	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	45					amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				CACGATGTTTGTGGGCTCTAT	0.418			NA											3	42					0	0	0.004672	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834498	101834498	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:101834498C>A	uc003knn.2	-	1	223	c.51G>T	c.(49-51)AGG>AGT	p.R17S	SLCO6A1_uc003kno.2_Missense_Mutation_p.R17S|SLCO6A1_uc003knp.2_Missense_Mutation_p.R17S|SLCO6A1_uc003knq.2_Missense_Mutation_p.R17S	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	17	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCTCTACTCCCCTTGAGACTT	0.677			NA											53	84					2.84144e-21	5.28438e-21	0.00361	1	0
EPB41L4A	64097	broad.mit.edu	37	5	111595633	111595633	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:111595633C>A	uc003kpv.1	-	8	960	c.686G>T	c.(685-687)GGT>GTT	p.G229V		NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	229	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CACAACAACACCAACCGGAGT	0.378			NA											13	15					0.00010058	0.00013054	0.001368	1	0
PCDHA13	56136	broad.mit.edu	37	5	140264024	140264024	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:140264024C>T	uc003lif.2	+	1	2171	c.2171C>T	c.(2170-2172)TCG>TTG	p.S724L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.S724L|PCDHA13_uc003lid.2_Missense_Mutation_p.S724L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	724	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGGTGCTCGGCACCGCCC	0.657	Melanoma(147;1739 1852 5500 27947 37288)		NA											21	76					0	0	0.003954	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736223	140736223	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:140736223C>T	uc003ljq.1	+	1	1456	c.1456C>T	c.(1456-1458)CGA>TGA	p.R486*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Nonsense_Mutation_p.R486*	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	486	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACAATGCCCGAATCACTTA	0.507			NA											37	113					0	0	0.004289	0	0
SLC26A2	1836	broad.mit.edu	37	5	149357882	149357882	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:149357882A>C	uc003lrh.2	+	2	935	c.667A>C	c.(667-669)AGC>CGC	p.S223R		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	223	Helical; (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TATGGTTGGCAGCACTGTAAC	0.353			NA											32	26					0	0	0.002836	0	0
CSF1R	1436	broad.mit.edu	37	5	149447883	149447883	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:149447883C>A	uc003lrl.2	-	10	1716	c.1521G>T	c.(1519-1521)ACG>ACT	p.T507T	CSF1R_uc011dcd.1_Silent_p.T359T|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Silent_p.T507T	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	507	Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCGGGGGATGCGTGTGGGCTC	0.433			NA											9	29					2.74318e-10	4.20437e-10	0.006214	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765873	171765873	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:171765873G>A	uc003mbr.2	-	13	2407	c.2236C>T	c.(2236-2238)CCT>TCT	p.P746S		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	746	Pro-rich.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTTGGAGAGGAACAGGCACG	0.602			NA											14	45					0	0	0.001855	0	0
HRH2	3274	broad.mit.edu	37	5	175111128	175111128	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:175111128G>A	uc003mdd.2	+	1	2665	c.892G>A	c.(892-894)GGG>AGG	p.G298R	HRH2_uc003mdc.3_Missense_Mutation_p.G298R	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	298	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CTTCCGCACCGGGTACCAACA	0.567			NA											14	27					0	0	0.001855	0	0
DSP	1832	broad.mit.edu	37	6	7569537	7569537	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:7569537C>A	uc003mxp.1	+	12	1817	c.1538C>A	c.(1537-1539)CCT>CAT	p.P513H	DSP_uc003mxq.1_Missense_Mutation_p.P513H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	513	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTGATCATCCCTCCTCCGAAC	0.577			NA											34	32					1.36161e-19	2.4429e-19	0.004289	1	0
DSP	1832	broad.mit.edu	37	6	7580653	7580653	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:7580653G>A	uc003mxp.1	+	23	4509	c.4230G>A	c.(4228-4230)AAG>AAA	p.K1410K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1410	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAGAAATAAAGAGGCTGAAGA	0.502			NA											22	27					0	0	0.001523	0	0
TFAP2D	83741	broad.mit.edu	37	6	50718983	50718983	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:50718983C>A	uc003paf.2	+	7	1597	c.1085C>A	c.(1084-1086)TCC>TAC	p.S362Y	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	362	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CTGGGATCCTCCAGACCCACT	0.353			NA											8	22					0.000274275	0.000350016	0.004482	1	0
FAM83B	222584	broad.mit.edu	37	6	54805349	54805349	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:54805349A>G	uc003pck.2	+	5	1696	c.1580A>G	c.(1579-1581)GAG>GGG	p.E527G		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	527										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					GATAATCCTGAGAATTTGAAG	0.398			NA											12	36					0	0	0.000978	0	0
LCA5	167691	broad.mit.edu	37	6	80223222	80223222	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:80223222G>C	uc003pix.2	-	3	862	c.427C>G	c.(427-429)CAG>GAG	p.Q143E	LCA5_uc003piy.2_Missense_Mutation_p.Q143E|LCA5_uc011dyq.1_RNA|LCA5_uc011dyr.1_Missense_Mutation_p.Q143E	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	143	Potential.				protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GCTTTCTCCTGTCTGTACTGA	0.363			NA											5	57					0	0	0.000602	0	0
TTK	7272	broad.mit.edu	37	6	80744812	80744812	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:80744812G>C	uc003pjc.2	+	15	1799	c.1725G>C	c.(1723-1725)TTG>TTC	p.L575F	TTK_uc003pjb.3_Missense_Mutation_p.L574F	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	575	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TAGCTTATTTGAATAAACTAC	0.279			NA											15	52					0	0	0.00499	0	0
FHL5	9457	broad.mit.edu	37	6	97063586	97063586	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:97063586C>T	uc003pos.1	+	7	1198	c.793C>T	c.(793-795)CTG>TTG	p.L265L	FHL5_uc003pot.1_Silent_p.L265L	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	265	LIM zinc-binding 4.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TAAAGGCTTCCTGACCCAGAA	0.483			NA											12	40					0	0	0.00245	0	0
NR2E1	7101	broad.mit.edu	37	6	108502054	108502054	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:108502054C>A	uc003psg.2	+	7	1538	c.783C>A	c.(781-783)ATC>ATA	p.I261I		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	261	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TGAACAAGATCATATCTGAAA	0.373			NA											24	77					1.96895e-08	2.84611e-08	0.00278	1	0
ZBTB24	9841	broad.mit.edu	37	6	109787215	109787215	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:109787215G>A	uc003ptl.1	-	7	2101	c.1933C>T	c.(1933-1935)CTG>TTG	p.L645L	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Silent_p.L589L|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		AGATGTTCCAGTGTTTCCTTG	0.502			NA											30	36					0	0	0.002096	0	0
FYN	2534	broad.mit.edu	37	6	111983047	111983047	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:111983047C>A	uc003pvj.2	-	13	1849	c.1509G>T	c.(1507-1509)TGG>TGT	p.W503C	FYN_uc003pvi.2_Missense_Mutation_p.W448C|FYN_uc003pvk.2_Missense_Mutation_p.W503C|FYN_uc003pvh.2_Missense_Mutation_p.W500C	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	503	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTCCTTTTTCCAGCAGTGGA	0.567			NA											59	89					1.80625e-27	3.57732e-27	0.00361	1	0
TAAR8	83551	broad.mit.edu	37	6	132874309	132874309	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:132874309C>T	uc011ecj.1	+	1	478	c.478C>T	c.(478-480)CTC>TTC	p.L160F		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	160	Helical; Name=4; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		GATTCTGCCTCTCACGTACAG	0.493			NA											108	119					0	0	0.00361	0	0
TIAM2	26230	broad.mit.edu	37	6	155465783	155465784	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:155465783_155465784GG>TT	uc003qqb.2	+	8	2947_2948	c.1674_1675GG>TT	c.(1672-1677)ATGGAT>ATTTAT	p.558_559MD>IY	TIAM2_uc003qqe.2_Missense_Mutation_p.558_559MD>IY|TIAM2_uc010kjj.2_Missense_Mutation_p.91_92MD>IY	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	558_559	PH 1.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGAATTCCATGGATCAGAGCAG	0.485			NA											29	41					0	0	0.004672	0	0
ARID1B	57492	broad.mit.edu	37	6	157521999	157521999	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:157521999C>T	uc003qqn.2	+	18	4369	c.4217C>T	c.(4216-4218)CCG>CTG	p.P1406L	ARID1B_uc003qqo.2_Missense_Mutation_p.P1366L|ARID1B_uc003qqp.2_Missense_Mutation_p.P1353L	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1411					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GGCCAGTACCCGTATCCCTAC	0.627			NA											4	33					0	0	0.000602	0	0
CYCS	54205	broad.mit.edu	37	7	25163735	25163735	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:25163735C>G	uc003sxl.2	-	2	149	c.4G>C	c.(4-6)GGT>CGT	p.G2R		NM_018947	NP_061820	P99999	CYC_HUMAN	cytochrome c	2					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			ovary(1)|lung(1)	2					Melatonin(DB01065)|Minocycline(DB01017)	TCAACATCACCCATATTTAAT	0.383			NA											5	41					0	0	0.001168	0	0
MAGI2	9863	broad.mit.edu	37	7	77824308	77824308	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:77824308G>A	uc003ugx.2	-	12	2406	c.2152C>T	c.(2152-2154)CCC>TCC	p.P718S	MAGI2_uc003ugy.2_Missense_Mutation_p.P718S|MAGI2_uc010ldx.1_Missense_Mutation_p.P327S|MAGI2_uc010ldy.1_Missense_Mutation_p.P327S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	718						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGTGGGAAGGGCAGGTTCTGC	0.517			NA											24	44					0	0	0.00278	0	0
CACNA2D1	781	broad.mit.edu	37	7	81593561	81593561	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:81593561C>A	uc003uhr.1	-	33	2945	c.2689G>T	c.(2689-2691)GCA>TCA	p.A897S	CACNA2D1_uc011kgy.1_Missense_Mutation_p.A109S	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	909	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGTTTTGGTGCAGCACCGGGC	0.423			NA											33	39					1.58521e-26	3.11928e-26	0.005524	1	0
LAMB4	22798	broad.mit.edu	37	7	107746332	107746332	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:107746332C>A	uc010ljo.1	-	8	884	c.800G>T	c.(799-801)TGC>TTC	p.C267F	LAMB4_uc003vey.2_Missense_Mutation_p.C267F	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	267	Laminin EGF-like 1.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ATGGCCATTGCAAAAGCAGCT	0.478			NA											25	33					5.45727e-16	9.24704e-16	0.008361	1	0
IQUB	154865	broad.mit.edu	37	7	123152037	123152037	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:123152037C>A	uc003vkn.2	-	2	935	c.358G>T	c.(358-360)GAA>TAA	p.E120*	IQUB_uc003vko.2_Nonsense_Mutation_p.E120*|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Nonsense_Mutation_p.E120*|IQUB_uc003vkq.2_Nonsense_Mutation_p.E120*	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	120										ovary(3)|large_intestine(1)	4						TGCAAAGATTCCTTTACAGAC	0.353			NA											13	24					3.27435e-08	4.64501e-08	0.00245	1	0
DGKI	9162	broad.mit.edu	37	7	137092687	137092687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:137092687A>T	uc003vtt.2	-	31	2879	c.2878T>A	c.(2878-2880)TGT>AGT	p.C960S	DGKI_uc003vtu.2_Missense_Mutation_p.C629S	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	960	ANK 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						AGGAGTGAACAGTGGTCTGGT	0.443			NA											35	56					0	0	0.003755	0	0
KEL	3792	broad.mit.edu	37	7	142651424	142651424	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:142651424C>A	uc003wcb.2	-	8	981	c.771G>T	c.(769-771)CTG>CTT	p.L257L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	257	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GCAAGGTTCCCAGCTGATTCA	0.542			NA											25	61					2.79863e-10	4.26791e-10	0.004656	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146997300	146997300	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:146997300C>T	uc003weu.1	+	9	1932	c.1416C>T	c.(1414-1416)CTC>CTT	p.L472L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	472	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTGCTATTCTCACCATCGATG	0.413			NA								HNSCC(39;0.1)			10	48					0	0	0.008291	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324854	150324854	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:150324854C>T	uc003whn.2	-	3	1256	c.832G>A	c.(832-834)GAA>AAA	p.E278K	GIMAP6_uc003whm.2_Missense_Mutation_p.E198K	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	278							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTCAGATTCCTTCTGGATC	0.572			NA											16	62					0	0	0.004007	0	0
KCNH2	3757	broad.mit.edu	37	7	150647303	150647303	+	Missense_Mutation	SNP	C	C	A	rs149588350		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:150647303C>A	uc003wic.2	-	9	2364	c.2351G>T	c.(2350-2352)CGG>CTG	p.R784L	KCNH2_uc003wib.2_Missense_Mutation_p.R444L|KCNH2_uc011kux.1_Missense_Mutation_p.R688L|KCNH2_uc003wid.2_Missense_Mutation_p.R444L|KCNH2_uc003wie.2_Missense_Mutation_p.R784L	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	784	Cytoplasmic (Potential).|cNMP.		R -> W (predisposes to LQT2 and torsades de pointes while taking the drug amiodarone; in vitro studies confirmed a significant reduction in potassium currents; the ECG abnormalities reversed on drug withdrawal).		blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GATGGAGCCCCGGGAGATGAA	0.647	GBM(137;110 1844 13671 20123 45161)		NA											28	57					3.73148e-12	5.8665e-12	0.007291	1	0
RNF32	140545	broad.mit.edu	37	7	156450897	156450897	+	Silent	SNP	C	C	A	rs149366944		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:156450897C>A	uc003wmo.2	+	6	708	c.526C>A	c.(526-528)CGA>AGA	p.R176R	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Silent_p.R176R|RNF32_uc003wmq.2_Silent_p.R176R|RNF32_uc003wmr.2_Silent_p.R176R|RNF32_uc003wms.2_Silent_p.R176R|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Silent_p.R176R	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	176						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GTATCAAACCCGAGTGATACA	0.463			NA											22	29					1.55795e-14	2.58246e-14	0.001882	1	0
CHRNB3	1142	broad.mit.edu	37	8	42587121	42587121	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:42587121C>A	uc003xpi.1	+	5	799	c.671C>A	c.(670-672)ACG>AAG	p.T224K		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	224	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CCCTTTATCACGTATTCCTTC	0.468			NA											20	34					4.96729e-08	6.98167e-08	0.008871	1	0
CHRNA6	8973	broad.mit.edu	37	8	42611537	42611537	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:42611537C>T	uc003xpj.2	-	5	851	c.805G>A	c.(805-807)GGT>AGT	p.G269S	CHRNA6_uc011lcw.1_Missense_Mutation_p.G254S	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	269						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ACTTTTTCACCACAGTCCGAA	0.423			NA											19	31					0	0	0.006122	0	0
KCNB2	9312	broad.mit.edu	37	8	73480446	73480446	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:73480446G>T	uc003xzb.2	+	2	1065	c.477G>T	c.(475-477)ATG>ATT	p.M159I		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	159	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CAGAGACTATGCGAGAGCGAG	0.468			NA											39	56					2.35958e-20	4.28377e-20	0.002222	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75924769	75924769	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:75924769G>T	uc003yan.2	+	3	735	c.360G>T	c.(358-360)TTG>TTT	p.L120F	CRISPLD1_uc011lfk.1_5'UTR|CRISPLD1_uc011lfl.1_5'UTR	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	120						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GACAGAATTTGGGAGCACACT	0.388			NA											25	29					2.52088e-20	4.54951e-20	0.00278	1	0
CSMD3	114788	broad.mit.edu	37	8	114326911	114326911	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:114326911G>C	uc003ynu.2	-	2	449	c.290C>G	c.(289-291)GCA>GGA	p.A97G	CSMD3_uc003ynt.2_Missense_Mutation_p.A57G|CSMD3_uc011lhx.1_Missense_Mutation_p.A97G|CSMD3_uc010mcx.1_Missense_Mutation_p.A97G|CSMD3_uc003ynx.3_Missense_Mutation_p.A97G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	97	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCGTTCTTCTGCTATTATTAC	0.358			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			65	80					0	0	0.00361	0	0
TAF1L	138474	broad.mit.edu	37	9	32634632	32634632	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:32634632C>A	uc003zrg.1	-	1	1036	c.946G>T	c.(946-948)GCT>TCT	p.A316S	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	316					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGTGGTGGAGCATAGTCATAG	0.473			NA											33	20					1.08312e-15	1.81512e-15	0.001786	1	0
FAM75A6	389730	broad.mit.edu	37	9	43627331	43627331	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:43627331A>T	uc011lrb.1	-	4	1385	c.1356T>A	c.(1354-1356)AAT>AAA	p.N452K		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	452						integral to membrane					0						TTGGGCAGACATTGGACATTT	0.517			NA											21	468					0	0	0.002299	0	0
FAM189A2	9413	broad.mit.edu	37	9	71992567	71992567	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:71992567G>T	uc010mon.1	+	6	505	c.401G>T	c.(400-402)GGA>GTA	p.G134V	FAM189A2_uc004ahg.2_Missense_Mutation_p.G134V|FAM189A2_uc010moo.1_5'UTR	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor	134						integral to membrane					0						GAGGATCATGGACGCATCCCC	0.527			NA											23	15					5.45024e-15	9.08373e-15	0.00333	1	0
TRPM6	140803	broad.mit.edu	37	9	77403579	77403579	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:77403579C>A	uc004ajl.1	-	20	2856	c.2618G>T	c.(2617-2619)TGG>TTG	p.W873L	TRPM6_uc004ajk.1_Missense_Mutation_p.W868L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	873	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GCTAACAAGCCACTCCTGCAC	0.498			NA											38	13					5.43694e-19	9.64108e-19	0.005524	1	0
LPAR1	1902	broad.mit.edu	37	9	113637828	113637828	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:113637828C>G	uc004bfa.2	-	5	1223	c.968G>C	c.(967-969)AGG>ACG	p.R323T	LPAR1_uc011lwm.1_Missense_Mutation_p.R324T|LPAR1_uc004bfb.2_Missense_Mutation_p.R323T|LPAR1_uc004bfc.2_Missense_Mutation_p.R323T|LPAR1_uc011lwn.1_Missense_Mutation_p.R305T|LPAR1_uc011lwo.1_Missense_Mutation_p.R324T|LPAR1_uc010mub.2_Missense_Mutation_p.R323T	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	323	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GAGGATCTGCCTAAAGGTGGC	0.547	NSCLC(115;661 2323 9836 34256)		NA											52	22					0	0	0.00361	0	0
LAMC3	10319	broad.mit.edu	37	9	133920910	133920910	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:133920910G>T	uc004caa.1	+	8	1481	c.1383_splice	c.e8-1	p.R461_splice		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor						cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCCATTTCAGATGTCGCCCG	0.607			NA											11	38					3.27435e-08	4.64501e-08	0.00245	1	0
STS	412	broad.mit.edu	37	X	7177623	7177623	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:7177623G>A	uc004cry.3	+	5	876	c.631G>A	c.(631-633)GTG>ATG	p.V211M		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	211	Cytoplasmic.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GCTACTCCACGTGCCTCTAGG	0.552			NA							Ichthyosis				18	77					0	0	0.008871	0	0
EGFL6	25975	broad.mit.edu	37	X	13607713	13607713	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:13607713C>A	uc004cvi.2	+	2	353	c.113C>A	c.(112-114)CCT>CAT	p.P38H	EGFL6_uc004cvj.2_Missense_Mutation_p.P38H|EGFL6_uc011mik.1_Translation_Start_Site	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	38					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						GCACGTCAGCCTGGGGTCTGT	0.458			NA											20	46					5.26018e-13	8.44397e-13	0.001882	1	0
EGFL6	25975	broad.mit.edu	37	X	13624535	13624535	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:13624535C>A	uc004cvi.2	+	6	798	c.558C>A	c.(556-558)CCC>CCA	p.P186P	EGFL6_uc004cvj.2_Silent_p.P186P|EGFL6_uc011mik.1_Silent_p.P87P	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	186	EGF-like 4; calcium-binding (Potential).				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TCATCTGTCCCTACAATCGAA	0.408			NA											32	67					3.76114e-14	6.20079e-14	0.004289	1	0
MAP7D2	256714	broad.mit.edu	37	X	20043197	20043197	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:20043197C>G	uc004czr.1	-	9	1180	c.1161G>C	c.(1159-1161)TTG>TTC	p.L387F	MAP7D2_uc004czq.1_Missense_Mutation_p.L272F|MAP7D2_uc011mji.1_Missense_Mutation_p.L335F|MAP7D2_uc010nfo.1_Missense_Mutation_p.L428F|MAP7D2_uc011mjj.1_Missense_Mutation_p.L342F	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	387										ovary(2)|breast(1)	3						TGGGCTTCCCCAAGGCTGCAC	0.517			NA											41	80					0	0	0.006999	0	0
GK	2710	broad.mit.edu	37	X	30709269	30709269	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:30709269G>T	uc004dch.3	+	5	546	c.367G>T	c.(367-369)GTT>TTT	p.V123F	GK_uc010ngj.2_Missense_Mutation_p.V123F|GK_uc004dci.3_Missense_Mutation_p.V123F|GK_uc011mjz.1_5'UTR|GK_uc011mka.1_5'UTR|GK_uc010ngk.2_5'UTR	NM_203391	NP_976325	P32189	GLPK_HUMAN	glycerol kinase isoform a	123					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1						CCAGTCTACCGTTGAGAGTCT	0.269			NA											31	56					9.17885e-22	1.71751e-21	0.003271	1	0
GK	2710	broad.mit.edu	37	X	30714174	30714174	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:30714174G>T	uc004dch.3	+	7	747	c.568G>T	c.(568-570)GTC>TTC	p.V190F	GK_uc010ngj.2_Missense_Mutation_p.V190F|GK_uc004dci.3_Missense_Mutation_p.V190F|GK_uc011mjz.1_5'UTR|GK_uc011mka.1_Missense_Mutation_p.V27F|GK_uc010ngk.2_5'UTR	NM_203391	NP_976325	P32189	GLPK_HUMAN	glycerol kinase isoform a	190					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1						GACAGGAGGAGTCAATGGAGG	0.363			NA											4	19					0.000602214	0.000758989	0.000602	1	0
DMD	1756	broad.mit.edu	37	X	32490369	32490369	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:32490369C>A	uc004dda.1	-	22	3105	c.2861G>T	c.(2860-2862)TGG>TTG	p.W954L	DMD_uc004dcz.2_Missense_Mutation_p.W831L|DMD_uc004dcy.1_Missense_Mutation_p.W950L|DMD_uc004ddb.1_Missense_Mutation_p.W946L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	954	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGCTGGACCCATGTCCTGAT	0.428			NA											23	35					6.21321e-17	1.05868e-16	0.00278	1	0
MAGEB16	139604	broad.mit.edu	37	X	35821063	35821063	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:35821063C>G	uc010ngt.1	+	2	1029	c.750C>G	c.(748-750)ATC>ATG	p.I250M		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	250	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GAATGCTCATCACCAAAGATT	0.502			NA											21	30					0	0	0.008871	0	0
RPGR	6103	broad.mit.edu	37	X	38146127	38146127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:38146127C>A	uc004ded.1	-	15	2293	c.2125G>T	c.(2125-2127)GAG>TAG	p.E709*	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						tgctcctgctcttccccatcc	0			NA											11	21					0.000673444	0.000845269	0.008291	1	0
OTC	5009	broad.mit.edu	37	X	38268137	38268137	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:38268137C>A	uc004def.3	+	8	940	c.726C>A	c.(724-726)ACC>ACA	p.T242T		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	242			T -> I (in OTCD; late onset).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	AGAATGGTACCAAGCTGTTGC	0.393			NA											19	55					1.67942e-08	2.43915e-08	0.006122	1	0
ITIH5L	347365	broad.mit.edu	37	X	54818409	54818409	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:54818409G>T	uc004dtj.2	-	3	348	c.318C>A	c.(316-318)ATC>ATA	p.I106I		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	106	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTTCTTCATAGATTTTCTTTG	0.368			NA											24	56					3.73148e-12	5.8665e-12	0.007291	1	0
FAM123B	139285	broad.mit.edu	37	X	63410547	63410547	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:63410547C>A	uc004dvo.2	-	2	2893	c.2620G>T	c.(2620-2622)GGA>TGA	p.G874*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	874					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCAGGCAGTCCCAAGTATCGA	0.577			NA											12	23					0.000978159	0.0012227	0.000978	1	0
MTMR8	55613	broad.mit.edu	37	X	63569937	63569937	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:63569937T>C	uc004dvs.2	-	5	550	c.482A>G	c.(481-483)TAC>TGC	p.Y161C	MTMR8_uc011mou.1_Missense_Mutation_p.Y161C|MTMR8_uc004dvt.1_Missense_Mutation_p.Y161C	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	161	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						TTCAGGAGGGTAGGTGCTGCA	0.348			NA											25	52					0	0	0.005443	0	0
HNRNPH2	3188	broad.mit.edu	37	X	100667052	100667052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:100667052G>T	uc004ehm.2	+	2	246	c.76G>T	c.(76-78)GAA>TAA	p.E26*	HNRNPH2_uc004ehn.2_Nonsense_Mutation_p.E26*	NM_019597	NP_062543	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2	26	RRM 1.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CTCAGCCGATGAAGTGATGCG	0.527			NA											19	82					1.67942e-08	2.43915e-08	0.006122	1	0
GPRASP2	114928	broad.mit.edu	37	X	101971017	101971017	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:101971017G>C	uc004ejk.2	+	4	2554	c.1220G>C	c.(1219-1221)TGT>TCT	p.C407S	GPRASP2_uc004ejl.2_Missense_Mutation_p.C407S|GPRASP2_uc004ejm.2_Missense_Mutation_p.C407S|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	407						cytoplasm	protein binding			ovary(1)	1						TCAGCAATCTGTGAATCTGAG	0.552			NA											33	68					0	0	0.005524	0	0
MCART6	401612	broad.mit.edu	37	X	103349839	103349839	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:103349839C>A	uc004elu.2	-	2	283	c.102G>T	c.(100-102)GGG>GGT	p.G34G		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	34	Helical; Name=1; (Potential).|Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0						TGGAAACGGCCCCAAGGGCAT	0.542			NA											10	55					0.000442599	0.00056247	0.006214	1	0
KIAA1210	57481	broad.mit.edu	37	X	118250553	118250553	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:118250553G>T	uc004era.3	-	4	556	c.556C>A	c.(556-558)CAG>AAG	p.Q186K		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	186										ovary(4)|skin(1)	5						TCTTCTTCCTGGGTATCTTCG	0.418			NA											9	21					0.00448238	0.00551261	0.004482	1	0
OCRL	4952	broad.mit.edu	37	X	128722933	128722933	+	Silent	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:128722933T>C	uc004euq.2	+	22	2577	c.2412T>C	c.(2410-2412)TGT>TGC	p.C804C	OCRL_uc004eur.2_Silent_p.C796C|OCRL_uc010nrb.2_RNA	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	804	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						CAGTCATCTGTTACGAGCTGT	0.527			NA											35	55					0	0	0.005524	0	0
BCORL1	63035	broad.mit.edu	37	X	129155073	129155073	+	Silent	SNP	G	G	A	rs61754128		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:129155073G>A	uc004evb.1	+	5	3669	c.3555G>A	c.(3553-3555)CCG>CCA	p.P1185P	BCORL1_uc010nrd.1_Silent_p.P1087P	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1185					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACCGGAAGCCGACAAAGCCGG	0.627			NA											16	36					0	0	0.00499	0	0
BCORL1	63035	broad.mit.edu	37	X	129185893	129185893	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:129185893A>T	uc004evb.1	+	12	4869	c.4755A>T	c.(4753-4755)CAA>CAT	p.Q1585H	BCORL1_uc004evc.1_Missense_Mutation_p.Q421H	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1585					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GCTCAGATCAAGAAGGAGACG	0.498			NA											60	117					0	0	0.00361	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130215645	130215645	+	Silent	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:130215645T>C	uc004evz.2	+	2	351	c.6T>C	c.(4-6)GGT>GGC	p.G2G	ARHGAP36_uc004ewa.2_Intron|ARHGAP36_uc004ewb.2_Intron|ARHGAP36_uc004ewc.2_5'Flank	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	2					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CCAGAATGGGTGGCTGCATTC	0.517			NA											35	47					0	0	0.003755	0	0
SLC9A6	10479	broad.mit.edu	37	X	135095150	135095150	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:135095150A>G	uc004ezj.2	+	8	1064	c.988A>G	c.(988-990)ACA>GCA	p.T330A	SLC9A6_uc004ezk.2_Missense_Mutation_p.T362A	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	330					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GTTGTTGGAGACAGGCCTGTT	0.438			NA											72	134					0	0	0.00361	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904663	144904663	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:144904663G>A	uc004fcd.2	+	5	1710	c.720G>A	c.(718-720)GAG>GAA	p.E240E	SLITRK2_uc010nsp.2_Silent_p.E240E|SLITRK2_uc010nso.2_Silent_p.E240E|SLITRK2_uc011mwq.1_Silent_p.E240E|SLITRK2_uc011mwr.1_Silent_p.E240E|SLITRK2_uc011mws.1_Silent_p.E240E|SLITRK2_uc004fcg.2_Silent_p.E240E|SLITRK2_uc011mwt.1_Silent_p.E240E	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	240	Extracellular (Potential).|LRRCT 1.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTGGGAGAGATTGTCTGTG	0.488			NA											42	85					0	0	0.006999	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905810	144905810	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:144905810C>G	uc004fcd.2	+	5	2857	c.1867C>G	c.(1867-1869)CTG>GTG	p.L623V	SLITRK2_uc010nsp.2_Missense_Mutation_p.L623V|SLITRK2_uc010nso.2_Missense_Mutation_p.L623V|SLITRK2_uc011mwq.1_Missense_Mutation_p.L623V|SLITRK2_uc011mwr.1_Missense_Mutation_p.L623V|SLITRK2_uc011mws.1_Missense_Mutation_p.L623V|SLITRK2_uc004fcg.2_Missense_Mutation_p.L623V|SLITRK2_uc011mwt.1_Missense_Mutation_p.L623V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	623	Helical; (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCTTAATTCTGGGATTGCT	0.453			NA											42	62					0	0	0.007835	0	0
TMEM79	84283	broad.mit.edu	37	1	156255576	156255576	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:156255576delG	uc010phi.1	+	2	755	c.559delG	c.(559-561)GGGfs	p.G187fs	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Frame_Shift_Del_p.G28fs|TMEM79_uc009wrw.2_Frame_Shift_Del_p.G187fs	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	187						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					CTGTTCCTGTGGGGGCTGCGG	0.667			NA											36	90	---	---	---	---	NA	NA	NA	NA	NA
TP53AIP1	63970	broad.mit.edu	37	11	128807581	128807582	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:128807581_128807582delGT	uc001qey.2	-	2	342_343	c.132_133delAC	c.(130-135)ACACCTfs	p.T44fs	TP53AIP1_uc001qex.2_Frame_Shift_Del_p.T44fs|TP53AIP1_uc009zcm.1_RNA			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	44_45					apoptosis	mitochondrion				lung(1)	1						ACCCAGCCAGGTGTGTGTGTCT	0.624			NA											8	58	---	---	---	---	NA	NA	NA	NA	NA
CNTN3	5067	broad.mit.edu	37	3	74411066	74411066	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:74411066delC	uc003dpm.1	-	10	1419	c.1339delG	c.(1339-1341)GATfs	p.D447fs		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	447	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACGCTCACATCCCCCTTCTTC	0.473			NA											17	69	---	---	---	---	NA	NA	NA	NA	NA
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:42196333delT	uc003osd.2	-	18	3916	c.3353delA	c.(3352-3354)AAGfs	p.K1118fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.K1035fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.K886fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.K874fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.K1138fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542			NA											8	2246	---	---	---	---	NA	NA	NA	NA	NA
ZNF318	24149	broad.mit.edu	37	6	43305681	43305681	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:43305681delC	uc003oux.2	-	10	6133	c.6055delG	c.(6055-6057)GATfs	p.D2019fs	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2019					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ACAGGCATATCCCCCAGATTC	0.458			NA											38	60	---	---	---	---	NA	NA	NA	NA	NA
CNR1	1268	broad.mit.edu	37	6	88853971	88853971	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:88853971delT	uc011dzq.1	-	2	4586	c.1023delA	c.(1021-1023)TTAfs	p.L341fs	CNR1_uc010kbz.2_Frame_Shift_Del_p.L341fs|CNR1_uc011dzr.1_Frame_Shift_Del_p.L341fs|CNR1_uc011dzs.1_Frame_Shift_Del_p.L341fs|CNR1_uc003pmq.3_Frame_Shift_Del_p.L341fs|CNR1_uc011dzt.1_Frame_Shift_Del_p.L341fs|CNR1_uc010kca.2_Frame_Shift_Del_p.L308fs	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	341	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GGGTCTTGGCTAACCTAATGT	0.537			NA											28	79	---	---	---	---	NA	NA	NA	NA	NA
AKAP9	10142	broad.mit.edu	37	7	91632378	91632378	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:91632378delG	uc003ulg.2	+	8	3372	c.3147delG	c.(3145-3147)ATGfs	p.M1049fs	AKAP9_uc003ule.2_Frame_Shift_Del_p.M1061fs|AKAP9_uc003ulf.2_Frame_Shift_Del_p.M1049fs|AKAP9_uc003uli.2_Frame_Shift_Del_p.M674fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1061					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAAAAATAATGGTGGAAGATA	0.338			NA	T	BRAF	papillary thyroid								22	29	---	---	---	---	NA	NA	NA	NA	NA
