Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	978663	978663	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:978663G>C	uc001ack.1	+	8	1479	c.1429G>C	c.(1429-1431)GCG>CCG	p.A477P		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	477					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TGCATTTGGGGCGACGTGTGC	0.662			NA											4	14					0	0	0.009096	0	0
SCNN1D	6339	broad.mit.edu	37	1	1221509	1221509	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:1221509G>T	uc001adu.1	+	6	894	c.270G>T	c.(268-270)CTG>CTT	p.L90L	SCNN1D_uc001adt.1_Silent_p.L254L|SCNN1D_uc001adw.2_Silent_p.L156L|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Silent_p.L90L	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CCTGGGGGCTGCTGTCCCTGG	0.682			NA											7	12					0.00198382	0.00205467	0.001984	1	0
MXRA8	54587	broad.mit.edu	37	1	1290159	1290159	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:1290159G>C	uc001aew.2	-	5	883	c.852C>G	c.(850-852)CGC>CGG	p.R284R	MXRA8_uc001aex.3_Silent_p.R284R|MXRA8_uc001aey.3_Silent_p.R284R|MXRA8_uc010nyl.1_Silent_p.R284R|MXRA8_uc001aez.2_Silent_p.R183R|MXRA8_uc001afa.2_Silent_p.R275R	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	284	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAAGACGCGGCGTTCGTGCA	0.711			NA											4	24					0	0	0.009096	0	0
PLCH2	9651	broad.mit.edu	37	1	2436043	2436043	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:2436043C>A	uc001aji.1	+	22	3916	c.3642C>A	c.(3640-3642)CCC>CCA	p.P1214P	PLCH2_uc010nyz.1_3'UTR|PLCH2_uc009vle.1_Silent_p.P966P|PLCH2_uc001ajj.1_3'UTR|PLCH2_uc001ajk.1_3'UTR|PLCH2_uc001ajl.1_Silent_p.P66P	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1214					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		AGCGGCCTCCCATACCTGACG	0.687			NA											22	46					7.41877e-09	8.2472e-09	0.012319	1	0
KIF1B	23095	broad.mit.edu	37	1	10327466	10327466	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:10327466G>C	uc001aqx.3	+	6	660	c.458G>C	c.(457-459)AGA>ACA	p.R153T	KIF1B_uc001aqv.3_Missense_Mutation_p.R153T|KIF1B_uc001aqw.3_Missense_Mutation_p.R153T|KIF1B_uc001aqy.2_Missense_Mutation_p.R153T|KIF1B_uc001aqz.2_Missense_Mutation_p.R153T|KIF1B_uc001ara.2_Missense_Mutation_p.R153T|KIF1B_uc001arb.2_Missense_Mutation_p.R153T|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	153	Kinesin-motor.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TACTGTGAAAGAGTACGAGAT	0.353			NA											4	50					0	0	0.001168	0	0
RSC1A1	6248	broad.mit.edu	37	1	15987288	15987288	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:15987288G>C	uc010obn.1	+	1	925	c.925G>C	c.(925-927)GAT>CAT	p.D309H		NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	309					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCACTCAGGATTTACAGCC	0.393			NA											12	51					0	0	0.010729	0	0
NBPF1	55672	broad.mit.edu	37	1	16895712	16895712	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:16895712C>G	uc009vos.1	-	23	3358	c.2470G>C	c.(2470-2472)GAG>CAG	p.E824Q	NBPF1_uc009vot.1_Missense_Mutation_p.E282Q|NBPF1_uc001ayz.1_Missense_Mutation_p.E282Q|NBPF1_uc010oce.1_Missense_Mutation_p.E553Q	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	824	NBPF 4.|Poly-Glu.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACTTCCTCCTCTTCAGACTCC	0.478			NA											8	195					0	0	0.001855	0	0
MST1P9	11223	broad.mit.edu	37	1	17087593	17087593	+	Silent	SNP	C	C	T	rs12145944	by1000genomes	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:17087593C>T	uc010ock.1	-	2	72	c.72G>A	c.(70-72)CAG>CAA	p.Q24Q	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'Flank	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ATGGCGAGCGCTGCCCTGCAG	0.577			NA											3	28					0	0	0.004672	0	0
HSPG2	3339	broad.mit.edu	37	1	22205522	22205522	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:22205522C>A	uc001bfj.2	-	18	2476	c.2436G>T	c.(2434-2436)CGG>CGT	p.R812R	HSPG2_uc009vqd.2_Silent_p.R813R	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	812	Laminin EGF-like 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AAGGGCAGGGCCGGCAGGAAG	0.552			NA											14	13					6.72482e-11	7.64132e-11	0.003163	1	0
CNKSR1	10256	broad.mit.edu	37	1	26514740	26514740	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:26514740C>G	uc001bln.3	+	17	1549	c.1491C>G	c.(1489-1491)CTC>CTG	p.L497L	CNKSR1_uc001blm.3_Silent_p.L490L|CNKSR1_uc009vsd.2_Silent_p.L232L|CNKSR1_uc009vse.2_Silent_p.L232L|CNKSR1_uc001blo.2_Silent_p.L232L|CATSPER4_uc010oey.1_5'Flank|CATSPER4_uc010oez.1_5'Flank|CATSPER4_uc009vsf.2_5'Flank	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	497	PH.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TGCGTCATCTCATTACCTGCA	0.418	NSCLC(180;1396 2109 28270 30756 34275)		NA											6	46					0	0	0.001984	0	0
FGR	2268	broad.mit.edu	37	1	27942117	27942117	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:27942117C>T	uc001boj.2	-	7	992	c.846G>A	c.(844-846)TGG>TGA	p.W282*	FGR_uc001boi.2_5'UTR|FGR_uc001bok.2_Nonsense_Mutation_p.W282*|FGR_uc001bol.2_Nonsense_Mutation_p.W282*|FGR_uc001bom.2_Nonsense_Mutation_p.W282*	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	282	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGCTGCCGTTCCACGTGCCTG	0.687			NA											5	21					0	0	0.001168	0	0
PTPRU	10076	broad.mit.edu	37	1	29639188	29639188	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:29639188C>G	uc001bru.2	+	23	3337	c.3227C>G	c.(3226-3228)CCT>CGT	p.P1076R	PTPRU_uc001brv.2_Missense_Mutation_p.P1072R|PTPRU_uc001brw.2_Missense_Mutation_p.P1066R|PTPRU_uc009vtq.2_Missense_Mutation_p.P1072R|PTPRU_uc009vtr.2_Missense_Mutation_p.P1063R	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1076	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		TCCACCCCACCTGATGCCGGG	0.642			NA											3	28					0	0	0.004672	0	0
C1orf113	79729	broad.mit.edu	37	1	36785389	36785389	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:36785389G>A	uc010oia.1	+	14	1153	c.1125G>A	c.(1123-1125)AAG>AAA	p.K375K	C1orf113_uc010oib.1_Silent_p.K264K|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Silent_p.K21K	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	259											0		Myeloproliferative disorder(586;0.0393)				CCAGCTCCAAGAAGATCCCGG	0.632			NA											7	32					0	0	0.001984	0	0
RIMKLA	284716	broad.mit.edu	37	1	42880471	42880471	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:42880471A>G	uc001chi.2	+	5	1140	c.1002A>G	c.(1000-1002)GGA>GGG	p.G334G		NM_173642	NP_775913	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family	334					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CAGCTCAGGGAGTTGCAGAGA	0.552			NA											12	41					0	0	0.001855	0	0
KIAA0467	23334	broad.mit.edu	37	1	43906216	43906216	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:43906216C>G	uc001cjk.1	+	37	5068	c.4606C>G	c.(4606-4608)CCA>GCA	p.P1536A		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2435						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCTGTGACTCCACCCAGCAA	0.592			NA											21	66					0	0	0.010504	0	0
RAD54L	8438	broad.mit.edu	37	1	46736385	46736385	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:46736385A>T	uc009vye.2	+	11	1211	c.1097A>T	c.(1096-1098)GAC>GTC	p.D366V	RAD54L_uc001cpl.2_Missense_Mutation_p.D366V|RAD54L_uc001cpm.1_Missense_Mutation_p.D186V	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	366					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AAGGGTCGAGACGCTGCTGCT	0.473			NA						Direct_reversal_of_damage|Homologous_recombination					9	43					0	0	0.004482	0	0
OMA1	115209	broad.mit.edu	37	1	59004832	59004832	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:59004832A>G	uc001cyy.2	-	2	223	c.135T>C	c.(133-135)CAT>CAC	p.H45H	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Silent_p.H45H|OMA1_uc009vzz.2_Silent_p.H45H	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	OMA1 homolog, zinc metallopeptidase precursor	45					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			large_intestine(1)	1	all_cancers(7;6.54e-05)					TATTTACTATATGGTTAACTT	0.368			NA											40	72					0	0	0.01441	0	0
EFCAB7	84455	broad.mit.edu	37	1	64021097	64021097	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:64021097G>A	uc001dbf.2	+	9	1419	c.1125G>A	c.(1123-1125)AGG>AGA	p.R375R		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	375							calcium ion binding				0						CTGGCTGTAGGCTGAGGAAAA	0.353			NA											24	70					0	0	0.003954	0	0
NEGR1	257194	broad.mit.edu	37	1	71873215	71873215	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:71873215C>T	uc001dfw.2	-	7	1079	c.979G>A	c.(979-981)GAT>AAT	p.D327N	NEGR1_uc001dfv.2_Missense_Mutation_p.D199N|NEGR1_uc010oqs.1_Missense_Mutation_p.D283N	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	327					cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AAAAGAACATCAGCGCTCCCG	0.403			NA											10	36					0	0	0.010729	0	0
C1orf173	127254	broad.mit.edu	37	1	75107038	75107038	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:75107038C>A	uc001dgg.2	-	5	640	c.421G>T	c.(421-423)GGA>TGA	p.G141*		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	141										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTGGAATGTCCTTCATCAACC	0.423			NA											18	66					8.00594e-06	8.59897e-06	0.007413	1	0
IFI44	10561	broad.mit.edu	37	1	79115896	79115896	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:79115896C>T	uc001dip.3	+	2	140	c.16C>T	c.(16-18)CGT>TGT	p.R6C	IFI44_uc010orr.1_Missense_Mutation_p.R6C|IFI44_uc010ors.1_Intron	NM_006417	NP_006408	Q8TCB0	IFI44_HUMAN	interferon-induced, hepatitis C-associated	6					response to virus	cytoplasm				ovary(1)|central_nervous_system(1)	2						AGTGACAACTCGTTTGACATG	0.348			NA											17	51					0	0	0.00499	0	0
PRKACB	5567	broad.mit.edu	37	1	84700929	84700929	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:84700929G>C	uc001djj.2	+	10	1261	c.997G>C	c.(997-999)GAA>CAA	p.E333Q	PRKACB_uc001djl.2_Missense_Mutation_p.E380Q|PRKACB_uc010ort.1_Missense_Mutation_p.E340Q|PRKACB_uc001djn.2_Missense_Mutation_p.E337Q|PRKACB_uc010oru.1_Missense_Mutation_p.E321Q|PRKACB_uc001djp.2_Missense_Mutation_p.E339Q|PRKACB_uc001djq.2_Missense_Mutation_p.E303Q|PRKACB_uc010orv.1_Missense_Mutation_p.E320Q	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	333	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TGACTATGAAGAAGAAGATAT	0.368			NA											15	55					0	0	0.007413	0	0
AMY2A	279	broad.mit.edu	37	1	104160583	104160583	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:104160583C>A	uc001dut.2	+	2	240	c.176C>A	c.(175-177)CCA>CAA	p.P59Q	AMY2A_uc010ouq.1_Missense_Mutation_p.P59Q	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	59					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	TAGGTCTCTCCACCAAATGAA	0.328			NA											28	104					1.7881e-09	2.00785e-09	0.008361	1	0
CELSR2	1952	broad.mit.edu	37	1	109812675	109812675	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:109812675G>A	uc001dxa.3	+	23	7289	c.7228G>A	c.(7228-7230)GGC>AGC	p.G2410S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2410	Cytoplasmic (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAACCAACACGGCATCCGACG	0.577	NSCLC(158;1285 2011 34800 34852 42084)		NA											18	64					0	0	0.00499	0	0
AMPD2	271	broad.mit.edu	37	1	110168300	110168300	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:110168300C>A	uc009wfh.1	+	4	943	c.401C>A	c.(400-402)TCA>TAA	p.S134*	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Nonsense_Mutation_p.S53*|AMPD2_uc001dyc.1_Nonsense_Mutation_p.S134*|AMPD2_uc010ovr.1_Nonsense_Mutation_p.S59*|AMPD2_uc010ovs.1_Nonsense_Mutation_p.S16*|AMPD2_uc001dyd.1_Nonsense_Mutation_p.S15*	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	134					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		TTCACCCGCTCACTGGCTGAG	0.667			NA											5	38					0.000602214	0.000629588	0.000602	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144866706	144866706	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:144866706C>G	uc001elw.3	-	34	5827	c.5536G>C	c.(5536-5538)GAG>CAG	p.E1846Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1740Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.E853Q|PDE4DIP_uc001ema.2_Missense_Mutation_p.E33Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1846	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCAAGATGCTCTTCCAGCAGG	0.597			NA	T	PDGFRB	MPD								5	108					0	0	0.000602	0	0
SEC22B	9554	broad.mit.edu	37	1	145109656	145109656	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:145109656G>T	uc001eml.1	+	5	458	c.318G>T	c.(316-318)GTG>GTT	p.V106V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	106	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						TGCCCACTGTGTCCCGACCCT	0.418			NA											32	774					2.75727e-19	3.3137e-19	0.004878	1	0
PRUNE	58497	broad.mit.edu	37	1	151006440	151006440	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:151006440C>T	uc001ewh.1	+	8	1228	c.1092C>T	c.(1090-1092)GAC>GAT	p.D364D	PRUNE_uc001ewi.1_Silent_p.D182D|PRUNE_uc010pco.1_Silent_p.D132D|PRUNE_uc001ewj.1_Silent_p.D79D|PRUNE_uc001ewk.1_Silent_p.D129D|BNIPL_uc009wmi.2_5'Flank|BNIPL_uc001ewl.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	364						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CATATTTTGACTCCATGAAGA	0.527			NA											11	157					0	0	0.008291	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151214946	151214946	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:151214946C>G	uc001exj.2	+	14	1995	c.1543C>G	c.(1543-1545)CAG>GAG	p.Q515E	PIP5K1A_uc001exi.2_Missense_Mutation_p.Q502E|PIP5K1A_uc010pcu.1_Missense_Mutation_p.Q475E|PIP5K1A_uc001exk.2_Missense_Mutation_p.Q453E|PIP5K1A_uc010pcv.1_Intron	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	515					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGTTTTACCTCAGACTCCACC	0.453	Pancreas(80;36 1443 2325 16095 21302)		NA											10	132					0	0	0.006214	0	0
TCHH	7062	broad.mit.edu	37	1	152080014	152080014	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:152080014C>G	uc001ezp.2	-	2	5679	c.5679G>C	c.(5677-5679)CAG>CAC	p.Q1893H	TCHH_uc009wne.1_Missense_Mutation_p.Q1893H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1893	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGGTGCCTCTGTTCCTCCT	0.567			NA											7	170					0	0	0.00308	0	0
ILF2	3608	broad.mit.edu	37	1	153642698	153642698	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:153642698C>G	uc001fcr.2	-	2	95	c.14G>C	c.(13-15)AGA>ACA	p.R5T	ILF2_uc010pdy.1_5'UTR|ILF2_uc009wok.2_Missense_Mutation_p.R5T|ILF2_uc009wol.1_5'UTR	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	5					immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCACGGCCTCTGTCACCCCT	0.512			NA											16	168					0	0	0.008871	0	0
GBA	2629	broad.mit.edu	37	1	155210461	155210461	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:155210461G>C	uc001fjh.2	-	2	225	c.75C>G	c.(73-75)CTC>CTG	p.L25L	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Silent_p.L25L|GBA_uc010pfx.1_Silent_p.L25L|GBA_uc001fji.2_Silent_p.L25L|GBA_uc001fjj.2_Silent_p.L25L|GBA_uc001fjk.2_Silent_p.L25L|GBA_uc001fjl.2_Silent_p.L25L|GBA_uc010pfy.1_Intron|GBA_uc009wqk.1_5'UTR	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	25					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GCAATCCTGTGAGGCTGCCAG	0.542			NA							Gaucher_disease_type_I				28	352					0	0	0.009535	0	0
SYT11	23208	broad.mit.edu	37	1	155851236	155851236	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:155851236G>A	uc001fmg.2	+	4	1496	c.1233G>A	c.(1231-1233)TGG>TGA	p.W411*	SYT11_uc010pgq.1_Nonsense_Mutation_p.W104*	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	411	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CTGAACACTGGAGAGAGGTCT	0.587			NA											8	192					0	0	0.00308	0	0
C1orf85	112770	broad.mit.edu	37	1	156264242	156264242	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:156264242C>G	uc001foh.2	-	3	506	c.493G>C	c.(493-495)GAT>CAT	p.D165H	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Missense_Mutation_p.D165H|C1orf85_uc009wrx.2_Intron|C1orf85_uc001foj.2_Missense_Mutation_p.D79H	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	165	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					GTGGCAGGATCCAATGAATCA	0.532			NA											11	96					0	0	0.010729	0	0
NES	10763	broad.mit.edu	37	1	156640601	156640601	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:156640601C>T	uc001fpq.2	-	4	3512	c.3379G>A	c.(3379-3381)GAG>AAG	p.E1127K		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1127	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCCAAACTCTCCTCTTCCAGG	0.642			NA											13	119					0	0	0.00245	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156909582	156909582	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:156909582G>A	uc001fqo.2	-	36	4774	c.3734C>T	c.(3733-3735)TCT>TTT	p.S1245F	ARHGEF11_uc010phu.1_Missense_Mutation_p.S661F|ARHGEF11_uc001fqn.2_Missense_Mutation_p.S1285F	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1245					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAGGGGTGAGAGGTGACGCT	0.652			NA											8	98					0	0	0.00308	0	0
CD1D	912	broad.mit.edu	37	1	158151368	158151368	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:158151368C>T	uc001frr.2	+	3	684	c.185C>T	c.(184-186)TCG>TTG	p.S62L	CD1D_uc009wsr.1_Missense_Mutation_p.S62L|CD1D_uc009wss.2_Missense_Mutation_p.S62L|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	62	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGCAACGACTCGGACACCGTC	0.622			NA											21	232					0	0	0.014323	0	0
OR10X1	128367	broad.mit.edu	37	1	158548974	158548974	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:158548974G>T	uc010pin.1	-	1	716	c.716C>A	c.(715-717)TCT>TAT	p.S239Y		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GAGGACAGTAGAAATAATGAA	0.468			NA											71	60					1.48005e-37	1.87323e-37	0.01441	1	0
OR10Z1	128368	broad.mit.edu	37	1	158576567	158576567	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:158576567C>T	uc010pio.1	+	1	339	c.339C>T	c.(337-339)TTC>TTT	p.F113F		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTAACTGCTTCCTTCTGGCTG	0.557			NA											28	215					0	0	0.007291	0	0
FCER1A	2205	broad.mit.edu	37	1	159273941	159273941	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:159273941G>C	uc001ftq.2	+	4	399	c.300G>C	c.(298-300)GAG>GAC	p.E100D		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	100	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	AAGTTAATGAGAGTGAACCTG	0.403			NA											7	151					0	0	0.010729	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921487	159921487	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:159921487C>G	uc001fus.2	-	4	951	c.834G>C	c.(832-834)TTG>TTC	p.L278F	SLAMF9_uc009wtd.2_Missense_Mutation_p.L187F|SLAMF9_uc001fut.2_3'UTR	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	278	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTCCTTCCTCAATTTCATTC	0.512			NA											19	157					0	0	0.012319	0	0
SLAMF9	89886	broad.mit.edu	37	1	159922201	159922201	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:159922201C>A	uc001fus.2	-	3	632	c.515G>T	c.(514-516)CGG>CTG	p.R172L	SLAMF9_uc009wtd.2_Intron|SLAMF9_uc001fut.2_Intron	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	172	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTATCCCCCCGGGAGAGCCA	0.577			NA											126	115					1.05089e-66	1.33259e-66	0.01441	1	0
PPOX	5498	broad.mit.edu	37	1	161140875	161140875	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:161140875G>C	uc001fyj.2	+	13	1633	c.1343G>C	c.(1342-1344)GGA>GCA	p.G448A	PPOX_uc001fyn.2_Missense_Mutation_p.G156A|PPOX_uc001fyg.2_Missense_Mutation_p.G448A|PPOX_uc001fyl.2_Missense_Mutation_p.G414A|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Missense_Mutation_p.G286A|PPOX_uc001fyh.2_Missense_Mutation_p.G286A|PPOX_uc010pkg.1_Missense_Mutation_p.G286A|PPOX_uc009wuc.1_Missense_Mutation_p.G249A|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Intron	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	448					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			ACTCTGGCTGGAGCCTCCTAT	0.532			NA							Porphyria_Variegata				11	258					0	0	0.010729	0	0
C1orf192	257177	broad.mit.edu	37	1	161334856	161334856	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:161334856G>C	uc001gal.2	-	5	439	c.433C>G	c.(433-435)CCA>GCA	p.P145A		NM_001013625	NP_001013647	Q5VTH2	CA192_HUMAN	hypothetical protein LOC257177	145											0	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GGGGAGCTTGGAATTATGGTT	0.488			NA											21	140					0	0	0.008871	0	0
C1orf114	57821	broad.mit.edu	37	1	169394108	169394108	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:169394108C>G	uc001gga.1	-	2	226	c.58G>C	c.(58-60)GAA>CAA	p.E20Q	C1orf114_uc001gfz.1_Missense_Mutation_p.E20Q|C1orf114_uc009wvq.1_Missense_Mutation_p.E20Q|C1orf114_uc001ggb.2_Missense_Mutation_p.E20Q|C1orf114_uc001ggc.1_Missense_Mutation_p.E20Q	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	20											0	all_hematologic(923;0.208)					AGGTCCTTTTCAAAGTCATCT	0.274			NA											9	75					0	0	0.006214	0	0
SELP	6403	broad.mit.edu	37	1	169581480	169581480	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:169581480C>T	uc001ggi.3	-	6	1001	c.936G>A	c.(934-936)TGG>TGA	p.W312*	SELP_uc001ggh.2_Nonsense_Mutation_p.W147*|SELP_uc009wvr.2_Nonsense_Mutation_p.W312*	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	312	Extracellular (Potential).|Sushi 2.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CTGGGGCTGTCCATACCCCCG	0.488			NA											13	108					0	0	0.004007	0	0
BAT2L2	23215	broad.mit.edu	37	1	171544252	171544252	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:171544252A>G	uc010pmg.1	+	25	7200	c.6934A>G	c.(6934-6936)ACA>GCA	p.T2312A	BAT2L2_uc010pmh.1_Missense_Mutation_p.T1224A|BAT2L2_uc010pmi.1_Missense_Mutation_p.T149A	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2312							protein C-terminus binding				0						AGTCACTCCTACAGCATCACT	0.388			NA											3	34					0	0	0.009096	0	0
BAT2L2	23215	broad.mit.edu	37	1	171544259	171544259	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:171544259C>G	uc010pmg.1	+	25	7207	c.6941C>G	c.(6940-6942)TCA>TGA	p.S2314*	BAT2L2_uc010pmh.1_Nonsense_Mutation_p.S1226*|BAT2L2_uc010pmi.1_Nonsense_Mutation_p.S151*	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2314							protein C-terminus binding				0						CCTACAGCATCACTATCAGGT	0.388			NA											3	33					0	0	0.009096	0	0
SLC9A11	284525	broad.mit.edu	37	1	173526632	173526632	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:173526632C>A	uc001giz.2	-	10	1485	c.1062G>T	c.(1060-1062)TTG>TTT	p.L354F	SLC9A11_uc009wwe.2_5'UTR|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	354	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GGCTCACTAACAAAATAGTAA	0.308			NA											23	157					2.39556e-15	2.83808e-15	0.00278	1	0
GPR52	9293	broad.mit.edu	37	1	174418080	174418080	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:174418080G>C	uc001gka.1	+	1	869	c.831G>C	c.(829-831)CTG>CTC	p.L277L	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron|uc010pmu.1_RNA	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	277	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						TTTATATGCTGTGGCTCCCCT	0.438	Ovarian(92;924 1390 1930 16467 40583)		NA											16	127					0	0	0.004007	0	0
TNN	63923	broad.mit.edu	37	1	175046812	175046812	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:175046812C>T	uc001gkl.1	+	2	371	c.258C>T	c.(256-258)TTC>TTT	p.F86F	TNN_uc010pmx.1_Silent_p.F86F	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	86					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACATCATCTTCAGGCACAACA	0.612			NA											9	41					0	0	0.004482	0	0
DHX9	1660	broad.mit.edu	37	1	182850485	182850485	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:182850485A>T	uc001gpr.2	+	23	2874	c.2711A>T	c.(2710-2712)CAT>CTT	p.H904L	DHX9_uc001gps.2_Missense_Mutation_p.H690L|DHX9_uc001gpt.2_Missense_Mutation_p.H183L|DHX9_uc009wyd.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	904					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						GGCTATATCCATCGAAATTTT	0.448	Colon(69;210 1162 3697 13559 39565)		NA											8	163					0	0	0.004482	0	0
KCNT2	343450	broad.mit.edu	37	1	196395074	196395074	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:196395074C>A	uc001gtd.1	-	11	1089	c.1029G>T	c.(1027-1029)CAG>CAT	p.Q343H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.Q343H|KCNT2_uc001gtf.1_Missense_Mutation_p.Q343H|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.Q343H|KCNT2_uc009wyv.1_Missense_Mutation_p.Q318H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	343	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CCCTTCGAACCTGTACATCCA	0.373			NA											16	73					6.49762e-13	7.55037e-13	0.006122	1	0
CFHR4	10877	broad.mit.edu	37	1	196881996	196881996	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:196881996C>G	uc001gto.2	+	3	452	c.383C>G	c.(382-384)TCT>TGT	p.S128C	CFHR4_uc009wyy.2_Missense_Mutation_p.S374C|CFHR4_uc001gtp.2_Missense_Mutation_p.S375C	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	128	Sushi 2.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GATGGAAATTCTTCAGGTTCA	0.294			NA											21	141					0	0	0.00278	0	0
KIF21B	23046	broad.mit.edu	37	1	200965360	200965360	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:200965360C>T	uc001gvs.1	-	15	2558	c.2241G>A	c.(2239-2241)AAG>AAA	p.K747K	KIF21B_uc001gvr.1_Silent_p.K747K|KIF21B_uc009wzl.1_Silent_p.K747K|KIF21B_uc010ppn.1_Silent_p.K747K	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	747	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CGGCCTGTAGCTTCTTCAGCT	0.607			NA											16	269					0	0	0.007413	0	0
TNNI1	7135	broad.mit.edu	37	1	201383732	201383732	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:201383732C>T	uc010ppq.1	-	5	196	c.103G>A	c.(103-105)GAG>AAG	p.E35K	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.E14K	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	35	Involved in binding TNC.				muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						TCGCGCTCCTCGTGCTCCTGC	0.662			NA											13	46					0	0	0.001855	0	0
ATP2B4	493	broad.mit.edu	37	1	203682343	203682343	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:203682343G>A	uc001gzw.2	+	14	3146	c.2262G>A	c.(2260-2262)GCG>GCA	p.A754A	ATP2B4_uc001gzv.2_Silent_p.A754A|ATP2B4_uc009xaq.2_Silent_p.A754A	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	754	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GGGTCCTGGCGCGATCTTCTC	0.542			NA											20	158					0	0	0.010504	0	0
LAX1	54900	broad.mit.edu	37	1	203740522	203740522	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:203740522T>C	uc001haa.2	+	3	637	c.227T>C	c.(226-228)GTC>GCC	p.V76A	LAX1_uc010pql.1_Missense_Mutation_p.V60A|LAX1_uc001hab.2_5'UTR	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	76	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGAGTTACCGTCATGCCCTTG	0.493			NA											26	337					0	0	0.005443	0	0
SRGAP2	23380	broad.mit.edu	37	1	206628307	206628307	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:206628307G>A	uc001hdy.2	+	18	2516	c.2183G>A	c.(2182-2184)AGA>AAA	p.R728K	SRGAP2_uc001hdx.2_Missense_Mutation_p.R728K|SRGAP2_uc010pru.1_Missense_Mutation_p.R651K	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	815					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					GTGACAGCCAGAGCGGGGGCC	0.537			NA											19	93					0	0	0.007413	0	0
SYT14	255928	broad.mit.edu	37	1	210267810	210267810	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:210267810A>T	uc009xcv.2	+	5	658	c.586A>T	c.(586-588)AAC>TAC	p.N196Y	SYT14_uc001hhs.3_Missense_Mutation_p.N241Y|SYT14_uc001hht.3_Missense_Mutation_p.N196Y|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.N241Y|SYT14_uc010pso.1_Missense_Mutation_p.N158Y	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	196	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CCACTGCAGCAACAGTCCAAG	0.423			NA											15	67					0	0	0.00499	0	0
KCNH1	3756	broad.mit.edu	37	1	211192440	211192440	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:211192440G>A	uc001hib.2	-	6	887	c.717C>T	c.(715-717)GTC>GTT	p.V239V	KCNH1_uc001hic.2_Silent_p.V239V	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	239	Helical; Name=Segment S1; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TTTTGAAGGAGACATTATAAG	0.418			NA											11	63					0	0	0.010729	0	0
SLC30A10	55532	broad.mit.edu	37	1	220101607	220101607	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:220101607T>C	uc001hlw.2	-	1	387	c.176A>G	c.(175-177)TAC>TGC	p.Y59C	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlx.2_5'UTR	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	59	Helical; (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		CCGGGCGATGTAGCCGGCGCT	0.701	Colon(76;360 1614 43677 51136)		NA											3	6					0	0	0.004672	0	0
OBSCN	84033	broad.mit.edu	37	1	228560439	228560439	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:228560439C>T	uc009xez.1	+	94	22004	c.21960C>T	c.(21958-21960)TTC>TTT	p.F7320F	OBSCN_uc001hsr.1_Silent_p.F1949F	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7320					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACCTCCCATTCGAGTTTATGA	0.602			NA											3	24					0	0	0.009096	0	0
URB2	9816	broad.mit.edu	37	1	229773396	229773396	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:229773396C>G	uc001hts.1	+	4	3172	c.3036C>G	c.(3034-3036)CTC>CTG	p.L1012L	URB2_uc009xfd.1_Silent_p.L1012L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1012						nucleolus				central_nervous_system(2)|ovary(1)	3						TGCAGATGCTCATCCAAATGA	0.448			NA											11	60					0	0	0.010729	0	0
MTR	4548	broad.mit.edu	37	1	237057700	237057700	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:237057700C>G	uc001hyi.3	+	30	3671	c.3248C>G	c.(3247-3249)TCA>TGA	p.S1083*	MTR_uc010pxw.1_Nonsense_Mutation_p.S676*|MTR_uc010pxx.1_Nonsense_Mutation_p.S1032*|MTR_uc010pxy.1_Nonsense_Mutation_p.S937*	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1083	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TACTGCCTCTCAGACTTCATC	0.572			NA											8	77					0	0	0.006214	0	0
RYR2	6262	broad.mit.edu	37	1	237660045	237660045	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:237660045C>G	uc001hyl.1	+	20	2316	c.2196C>G	c.(2194-2196)CTC>CTG	p.L732L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	732	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCTTCATCTCTGGTCAGGTA	0.473			NA											25	155					0	0	0.005443	0	0
RYR2	6262	broad.mit.edu	37	1	237711840	237711840	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:237711840G>T	uc001hyl.1	+	26	3136	c.3016G>T	c.(3016-3018)GTG>TTG	p.V1006L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1006	Cytoplasmic (By similarity).|2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCACATAATGTGTGGGCGCG	0.488			NA											12	30					5.50884e-06	5.92644e-06	0.013537	1	0
RYR2	6262	broad.mit.edu	37	1	237801676	237801676	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:237801676G>T	uc001hyl.1	+	45	6932	c.6812G>T	c.(6811-6813)GGT>GTT	p.G2271V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2271	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TATTTGGCTGGTTGTGGACTG	0.403			NA											36	101					4.3181e-19	5.18017e-19	0.013726	1	0
OR2G3	81469	broad.mit.edu	37	1	247768923	247768923	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:247768923C>T	uc010pyz.1	+	1	36	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TAATGGATTTCATCCTTCTAG	0.468			NA											12	76					0	0	0.001855	0	0
OR14A16	284532	broad.mit.edu	37	1	247979009	247979009	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:247979009G>T	uc001idm.1	-	1	23	c.23C>A	c.(22-24)ACT>AAT	p.T8N		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATAAATTCAGTCACGATTGT	0.338	Ovarian(112;180 1586 15073 21914 33526)		NA											4	42					0.00024832	0.000260834	0.009096	1	0
OR2T12	127064	broad.mit.edu	37	1	248458293	248458293	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:248458293G>A	uc010pzj.1	-	1	588	c.588C>T	c.(586-588)GCC>GCT	p.A196A		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AGATGTACATGGCGTTTTCGA	0.537			NA											14	95					0	0	0.001855	0	0
FBXO18	84893	broad.mit.edu	37	10	5948241	5948241	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:5948241G>T	uc001iis.2	+	3	494	c.399G>T	c.(397-399)CAG>CAT	p.Q133H	FBXO18_uc001iir.2_Missense_Mutation_p.Q59H|FBXO18_uc009xig.2_Missense_Mutation_p.Q59H|FBXO18_uc001iit.2_Missense_Mutation_p.Q184H	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	133					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AGAGTAACCAGGCTACCGGGA	0.622			NA											9	26					2.74318e-10	3.10119e-10	0.006214	1	0
KIN	22944	broad.mit.edu	37	10	7822262	7822262	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:7822262C>T	uc001ijt.2	-	3	266	c.218G>A	c.(217-219)CGA>CAA	p.R73Q	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.R73Q|KIN_uc010qba.1_5'UTR	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	73					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAAGTCATTTCGGAATTCCCT	0.294			NA											6	54					0	0	0.001984	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505151	37505151	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:37505151G>T	uc001iza.1	+	32	2843	c.2744G>T	c.(2743-2745)TGT>TTT	p.C915F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	971						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTTCATTCTTGTGAAAGAGCA	0.333			NA											22	36					5.35356e-11	6.10397e-11	0.00278	1	0
BMS1	9790	broad.mit.edu	37	10	43326498	43326498	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:43326498G>C	uc001jaj.2	+	23	4161	c.3803G>C	c.(3802-3804)AGA>ACA	p.R1268T		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	1268					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						AAGGAAAGAAGAAACCAGAAG	0.537			NA											3	12					0	0	0.009096	0	0
LOC100133308	100133308	broad.mit.edu	37	10	45611486	45611486	+	Splice_Site	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:45611486C>T	uc001jbz.2	-	4		c.265_splice	c.e4-1		LOC100133308_uc009xmq.1_RNA					Homo sapiens cDNA FLJ32851 fis, clone TESTI2003432.												0						TTCTTCAGTTCTGCTGTGTTT	0.448			NA											6	29					0	0	0.001168	0	0
CCDC6	8030	broad.mit.edu	37	10	61666021	61666021	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:61666021G>A	uc001jks.3	-	1	798	c.162C>T	c.(160-162)TTC>TTT	p.F54F		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	54	Potential.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		CCTCCAGGCGGAACGGCGAGA	0.493			NA											45	62					0	0	0.01441	0	0
EGR2	1959	broad.mit.edu	37	10	64573000	64573000	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:64573000G>A	uc010qim.1	-	3	1552	c.1398C>T	c.(1396-1398)CTC>CTT	p.L466L	EGR2_uc010qin.1_Silent_p.L416L|EGR2_uc001jmi.2_Silent_p.L466L|EGR2_uc010qio.1_Silent_p.L479L|EGR2_uc009xph.2_Silent_p.L466L	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	466					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGCAAGGGGCGAGCGGCCCTC	0.652			NA											17	73					0	0	0.00499	0	0
LRRTM3	347731	broad.mit.edu	37	10	68857373	68857373	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:68857373T>A	uc001jmz.1	+	3	2115	c.1565T>A	c.(1564-1566)TTT>TAT	p.F522Y	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	522	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GTGTCAACCTTTCTGGCATAC	0.398			NA											5	68					0	0	0.000602	0	0
CHCHD1	118487	broad.mit.edu	37	10	75542100	75542100	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:75542100G>C	uc001jvc.3	+	2	170	c.144G>C	c.(142-144)GAG>GAC	p.E48D	CHCHD1_uc001jvb.2_Missense_Mutation_p.E48D	NM_203298	NP_976043	Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain	48	CHCH.					nucleus					0	Prostate(51;0.0112)					GCATCACGGAGATGTCGGTGA	0.602			NA											16	41					0	0	0.004007	0	0
HPSE2	60495	broad.mit.edu	37	10	100481571	100481571	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:100481571G>A	uc001kpn.1	-	5	859	c.799C>T	c.(799-801)CGG>TGG	p.R267W	HPSE2_uc009xwc.1_Missense_Mutation_p.R257W|HPSE2_uc001kpo.1_Missense_Mutation_p.R199W|HPSE2_uc009xwd.1_Missense_Mutation_p.R145W	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	267					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TGCATGGTCCGATAGTTATTT	0.473			NA											24	67					0	0	0.004656	0	0
BTRC	8945	broad.mit.edu	37	10	103292112	103292112	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:103292112G>C	uc001kta.2	+	8	1014	c.901G>C	c.(901-903)GAA>CAA	p.E301Q	BTRC_uc001ktb.2_Missense_Mutation_p.E265Q|BTRC_uc001ktc.2_Missense_Mutation_p.E275Q	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	301	WD 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTGCCGAAGTGAAACAAGCAA	0.393			NA											15	98					0	0	0.003163	0	0
C10orf79	80217	broad.mit.edu	37	10	105947204	105947204	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:105947204G>C	uc001kxw.2	-	14	1850	c.1734C>G	c.(1732-1734)ATC>ATG	p.I578M	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.I579M	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	578											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		ACTTATGAATGATTTCATCTT	0.368			NA											11	48					0	0	0.013537	0	0
SMC3	9126	broad.mit.edu	37	10	112341740	112341740	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:112341740C>G	uc001kze.2	+	9	733	c.607C>G	c.(607-609)CTA>GTA	p.L203V		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	203	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		ATTACATACTCTAGAGGAAGA	0.378			NA											22	96					0	0	0.014323	0	0
TDRD1	56165	broad.mit.edu	37	10	115970636	115970636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:115970636C>T	uc001lbg.1	+	13	1723	c.1570C>T	c.(1570-1572)CAG>TAG	p.Q524*	TDRD1_uc001lbf.2_Nonsense_Mutation_p.Q515*|TDRD1_uc001lbh.1_Nonsense_Mutation_p.Q515*|TDRD1_uc001lbi.1_Nonsense_Mutation_p.Q515*|TDRD1_uc010qsc.1_Nonsense_Mutation_p.Q185*|TDRD1_uc001lbj.2_Nonsense_Mutation_p.Q233*	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	524					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGCTGAACTTCAGGCATCCCT	0.393			NA											12	55					0	0	0.001855	0	0
ATRNL1	26033	broad.mit.edu	37	10	116889092	116889092	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:116889092C>G	uc001lcg.2	+	5	1010	c.624C>G	c.(622-624)ATC>ATG	p.I208M	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.I208M|ATRNL1_uc009xyq.2_Missense_Mutation_p.I208M	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	208	CUB.|EGF-like 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTTACAGAATCAATTCTTGTC	0.303			NA											6	48					0	0	0.00308	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118236285	118236285	+	Silent	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:118236285T>C	uc001lcl.3	+	11	1395	c.1294T>C	c.(1294-1296)TTG>CTG	p.L432L		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	432	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TCAGAATAAGTTGGGAGCAGA	0.308			NA											27	33					0	0	0.005443	0	0
INPP5F	22876	broad.mit.edu	37	10	121541266	121541266	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:121541266C>G	uc001leo.2	+	3	464	c.298C>G	c.(298-300)CAG>GAG	p.Q100E	INPP5F_uc001len.3_Missense_Mutation_p.Q100E	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	100							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		AATGGAACCTCAGGATCTTGA	0.398			NA											14	40					0	0	0.00245	0	0
DMBT1	1755	broad.mit.edu	37	10	124348479	124348479	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:124348479C>G	uc001lgk.1	+	17	1909	c.1803C>G	c.(1801-1803)GCC>GCG	p.A601A	DMBT1_uc001lgl.1_Silent_p.A591A|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Silent_p.A601A|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	601					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCAGTTTGGCCCTGAGGCTGG	0.542	Ovarian(182;93 2026 18125 22222 38972)		NA											62	227					0	0	0.01441	0	0
SYCE1	93426	broad.mit.edu	37	10	135369180	135369180	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:135369180C>T	uc001lno.2	-	11	856	c.751G>A	c.(751-753)GAG>AAG	p.E251K	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.E123K|SYCE1_uc009ybn.2_Missense_Mutation_p.E251K|SYCE1_uc001lnn.2_Missense_Mutation_p.E215K	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	251	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGGAGCTCCTCAGCCTTCCTG	0.438			NA											8	48					0	0	0.00308	0	0
MUC6	4588	broad.mit.edu	37	11	1025347	1025347	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:1025347C>T	uc001lsw.2	-	23	2871	c.2820G>A	c.(2818-2820)GCG>GCA	p.A940A		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	940	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTTTCTGTCCGCCAGCACCA	0.682			NA											12	43					0	0	0.010729	0	0
HBD	3045	broad.mit.edu	37	11	5254244	5254244	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:5254244G>C	uc001maf.1	-	3	589	c.394C>G	c.(394-396)CAG>GAG	p.Q132E		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	132					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCACCTTCTGATAGGCAGCC	0.522			NA											16	79					0	0	0.003163	0	0
OR52N5	390075	broad.mit.edu	37	11	5799669	5799669	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:5799669G>A	uc010qzn.1	-	1	196	c.196C>T	c.(196-198)CCG>TCG	p.P66S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AAATACATCGGATGATGTAAG	0.453			NA											13	83					0	0	0.001855	0	0
TRIM3	10612	broad.mit.edu	37	11	6472225	6472225	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:6472225G>C	uc001mdh.2	-	10	2154	c.1767C>G	c.(1765-1767)ATC>ATG	p.I589M	TRIM3_uc001mdi.2_Missense_Mutation_p.I589M|TRIM3_uc010raj.1_Missense_Mutation_p.I470M|TRIM3_uc009yfd.2_Missense_Mutation_p.I589M|TRIM3_uc010rak.1_Missense_Mutation_p.I589M	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	589	NHL 3.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGACCACAATGATATGTCCAT	0.552	Melanoma(6;5 510 1540 25169 29084)		NA											4	54					0	0	0.000602	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7674426	7674426	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:7674426G>C	uc001mfj.3	+	24	2996	c.2608G>C	c.(2608-2610)GAC>CAC	p.D870H	PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.D804H|PPFIBP2_uc010rbe.1_Missense_Mutation_p.D758H|PPFIBP2_uc001mfl.3_Missense_Mutation_p.D727H|PPFIBP2_uc009yfj.1_Missense_Mutation_p.D514H	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	870					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GGATGGGCTGGACCAGGTGGG	0.572			NA											9	53					0	0	0.006214	0	0
C11orf16	56673	broad.mit.edu	37	11	8943023	8943023	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:8943023T>C	uc001mhb.3	-	6	1368	c.1244A>G	c.(1243-1245)CAC>CGC	p.H415R	C11orf16_uc001mhc.3_Intron	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	415										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		CTGCTGTTTGTGATCCTTTTC	0.468			NA											49	75					0	0	0.01441	0	0
SBF2	81846	broad.mit.edu	37	11	9810801	9810801	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:9810801C>G	uc001mib.2	-	35	4925	c.4787G>C	c.(4786-4788)TGG>TCG	p.W1596S	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.W240S|SBF2_uc001mic.2_5'Flank|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1596					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TAGCATCATCCAGTCATAGGA	0.517			NA											11	90					0	0	0.013537	0	0
MICAL2	9645	broad.mit.edu	37	11	12247773	12247773	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:12247773G>C	uc001mjz.2	+	14	2032	c.1744G>C	c.(1744-1746)GAT>CAT	p.D582H	MICAL2_uc010rch.1_Missense_Mutation_p.D582H|MICAL2_uc001mka.2_Missense_Mutation_p.D582H|MICAL2_uc010rci.1_Missense_Mutation_p.D582H|MICAL2_uc001mkb.2_Missense_Mutation_p.D582H|MICAL2_uc001mkc.2_Missense_Mutation_p.D582H|MICAL2_uc001mkd.2_Missense_Mutation_p.D411H|MICAL2_uc010rcj.1_5'UTR	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	582	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GCTCGCATTTGATGTGGCCGA	0.507			NA											10	68					0	0	0.008291	0	0
TMEM86A	144110	broad.mit.edu	37	11	18723357	18723357	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:18723357C>T	uc001moz.1	+	3	607	c.524C>T	c.(523-525)ACA>ATA	p.T175I		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	175	Helical; (Potential).					integral to membrane				ovary(1)	1						TGGCGCTGGACAGAGCTGGCA	0.602			NA											13	24					0	0	0.001855	0	0
NELL1	4745	broad.mit.edu	37	11	21594939	21594939	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:21594939C>A	uc001mqe.2	+	19	2519	c.2366C>A	c.(2365-2367)ACA>AAA	p.T789K	NELL1_uc001mqf.2_Missense_Mutation_p.T742K|NELL1_uc009yid.2_Missense_Mutation_p.T817K|NELL1_uc010rdo.1_Missense_Mutation_p.T732K|NELL1_uc010rdp.1_Missense_Mutation_p.T502K|NELL1_uc001mqh.2_Missense_Mutation_p.T334K	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	789	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TCTCCCTGCACAACCTGTAAA	0.468			NA											29	71					3.73148e-12	4.29861e-12	0.007291	1	0
MUC15	143662	broad.mit.edu	37	11	26582638	26582638	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:26582638T>A	uc001mqx.2	-	4	1245	c.979A>T	c.(979-981)ATA>TTA	p.I327L	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.I354L|MUC15_uc001mqy.2_Missense_Mutation_p.I304L	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	327	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGTGGAGGTATGTCATCCATA	0.388			NA											16	55					0	0	0.010504	0	0
BBOX1	8424	broad.mit.edu	37	11	27114762	27114762	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:27114762G>A	uc001mre.1	+	5	750	c.382G>A	c.(382-384)GAA>AAA	p.E128K	BBOX1_uc009yih.1_Missense_Mutation_p.E128K|BBOX1_uc001mrg.1_Missense_Mutation_p.E128K	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	128					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TTTGGATTTTGAAGATGTTTT	0.408			NA											9	40					0	0	0.004482	0	0
BBOX1	8424	broad.mit.edu	37	11	27141314	27141315	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:27141314_27141315CC>AT	uc001mre.1	+	7	1126_1127	c.758_759CC>AT	c.(757-759)TCC>TAT	p.S253Y	BBOX1_uc009yih.1_Missense_Mutation_p.S253Y|BBOX1_uc001mrg.1_Missense_Mutation_p.S253Y	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	253					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	CAGATTTTGTCCTCTACCTTTG	0.332			NA											13	42					0	0	0.004672	0	0
LGR4	55366	broad.mit.edu	37	11	27393196	27393196	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:27393196A>G	uc001mrj.3	-	17	2030	c.1545T>C	c.(1543-1545)CAT>CAC	p.H515H	LGR4_uc001mrk.3_Silent_p.H491H	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	515	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						TTATTTGACTATGTTCTTCAT	0.333			NA											11	72					0	0	0.010729	0	0
TRIM44	54765	broad.mit.edu	37	11	35827924	35827924	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:35827924G>A	uc001mwi.2	+	5	1331	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K		NM_017583	NP_060053	Q96DX7	TRI44_HUMAN	DIPB protein	342						intracellular	protein binding|zinc ion binding			skin(1)	1	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				CAGTGAAGAAGAGGACACATG	0.373			NA											19	83					0	0	0.010504	0	0
RAG2	5897	broad.mit.edu	37	11	36614707	36614707	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:36614707C>A	uc001mwv.3	-	2	1200	c.1012G>T	c.(1012-1014)GTT>TTT	p.V338F	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	338					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TCTGAAACAACTTGTTTATTG	0.383			NA							Familial_Hemophagocytic_Lymphohistiocytosis				34	149					1.99505e-19	2.40199e-19	0.012213	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136944	40136944	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:40136944T>A	uc001mxa.1	-	2	2863	c.899A>T	c.(898-900)CAC>CTC	p.H300L	LRRC4C_uc001mxc.1_Missense_Mutation_p.H296L|LRRC4C_uc001mxd.1_Missense_Mutation_p.H296L|LRRC4C_uc001mxb.1_Missense_Mutation_p.H296L	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	300					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CCAAGGGTTGTGATGTAAATG	0.478			NA											31	53					0	0	0.010818	0	0
DGKZ	8525	broad.mit.edu	37	11	46397681	46397681	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:46397681G>C	uc001ncn.1	+	23	2766	c.2641G>C	c.(2641-2643)GAG>CAG	p.E881Q	DGKZ_uc001nch.1_Missense_Mutation_p.E709Q|DGKZ_uc010rgq.1_Missense_Mutation_p.E636Q|DGKZ_uc001ncj.1_Missense_Mutation_p.E659Q|DGKZ_uc010rgr.1_Missense_Mutation_p.E658Q|DGKZ_uc001nck.1_Missense_Mutation_p.E471Q|DGKZ_uc001ncl.2_Missense_Mutation_p.E693Q|DGKZ_uc001ncm.2_Missense_Mutation_p.E692Q|DGKZ_uc009yky.1_Missense_Mutation_p.E693Q|DGKZ_uc010rgs.1_Missense_Mutation_p.E670Q	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	881					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCCCACATTGAGAGACTCCA	0.657			NA											11	61					0	0	0.010729	0	0
FNBP4	23360	broad.mit.edu	37	11	47746106	47746106	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:47746106C>T	uc009ylv.2	-	13	2386	c.2233G>A	c.(2233-2235)GAG>AAG	p.E745K	FNBP4_uc001ngi.2_Missense_Mutation_p.E59K|FNBP4_uc001ngj.2_Missense_Mutation_p.E652K|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	745										ovary(1)	1						TCACTTCCCTCATCCTCCATC	0.408			NA											21	103					0	0	0.012319	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735853	55735853	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:55735853G>T	uc010rit.1	-	1	87	c.87C>A	c.(85-87)ATC>ATA	p.I29I		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TGCACATCAGGATCATCAAAT	0.333			NA											30	34					2.12542e-12	2.45694e-12	0.00632	1	0
OR5J2	282775	broad.mit.edu	37	11	55944604	55944604	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:55944604C>A	uc010rjb.1	+	1	511	c.511C>A	c.(511-513)CTA>ATA	p.L171I		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTTTTGTAGGCTAAATGCTGT	0.438			NA											17	41					1.45105e-14	1.70396e-14	0.006122	1	0
GIF	2694	broad.mit.edu	37	11	59604819	59604819	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:59604819G>C	uc001noi.2	-	6	747	c.699C>G	c.(697-699)CTC>CTG	p.L233L		NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	233					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						GTGTTACAGAGAGAGCCTGGG	0.413	NSCLC(53;1139 1245 16872 38474 42853)		NA											5	16					0	0	0.000602	0	0
MS4A6A	64231	broad.mit.edu	37	11	59940556	59940556	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:59940556A>G	uc001nor.2	-	6	834	c.596T>C	c.(595-597)CTA>CCA	p.L199P	MS4A6A_uc001noq.2_Silent_p.P164P|MS4A6A_uc001nos.3_Missense_Mutation_p.L227P|MS4A6A_uc009ymv.2_Missense_Mutation_p.L199P|MS4A6A_uc001not.2_Missense_Mutation_p.L199P|MS4A6A_uc010rla.1_Missense_Mutation_p.L227P|MS4A6A_uc010rlb.1_Missense_Mutation_p.L154P	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	199	Helical; (Potential).					integral to membrane	receptor activity				0						GAGCACAGCTAGGCAGAATTC	0.488			NA											26	80					0	0	0.009535	0	0
AHNAK	79026	broad.mit.edu	37	11	62299280	62299280	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:62299280C>A	uc001ntl.2	-	5	2909	c.2609G>T	c.(2608-2610)GGC>GTC	p.G870V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	870					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCAGTCTGGGCCTTGAACCTC	0.478			NA											64	174					2.36135e-34	2.97174e-34	0.01441	1	0
ROM1	6094	broad.mit.edu	37	11	62381824	62381824	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:62381824C>A	uc001ntv.2	+	2	1226	c.685C>A	c.(685-687)CGT>AGT	p.R229S	EML3_uc001ntr.1_5'Flank|EML3_uc001nts.1_5'Flank|EML3_uc001ntt.1_5'Flank|EML3_uc001ntu.1_5'Flank|EML3_uc010rly.1_5'Flank	NM_000327	NP_000318	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	229	Lumenal (Potential).		R -> H.		cell adhesion|visual perception	integral to plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCTGCAAAACCGTCTTTCAGA	0.587			NA											19	69					7.07596e-05	7.49153e-05	0.006122	1	0
GANAB	23193	broad.mit.edu	37	11	62397071	62397071	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:62397071G>A	uc001nub.2	-	15	1856	c.1823C>T	c.(1822-1824)TCC>TTC	p.S608F	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Missense_Mutation_p.S630F|GANAB_uc001nuc.2_Missense_Mutation_p.S511F|GANAB_uc010rma.1_Missense_Mutation_p.S516F|GANAB_uc010rmb.1_Missense_Mutation_p.S494F	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	608					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						AAAGCGCTGGGAGCCAGCGAA	0.602	Melanoma(23;1005 1074 15747 18937)		NA											7	26					0	0	0.004482	0	0
TIGD3	220359	broad.mit.edu	37	11	65124466	65124466	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:65124466T>A	uc001odo.3	+	2	1350	c.1187T>A	c.(1186-1188)GTG>GAG	p.V396E		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	396					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TCCCGCTTTGTGGACCTGGAG	0.622			NA											18	71					0	0	0.007413	0	0
TIGD3	220359	broad.mit.edu	37	11	65124468	65124468	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:65124468G>A	uc001odo.3	+	2	1352	c.1189G>A	c.(1189-1191)GAC>AAC	p.D397N		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	397					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CCGCTTTGTGGACCTGGAGGG	0.622			NA											19	71					0	0	0.007413	0	0
SCYL1	57410	broad.mit.edu	37	11	65293487	65293487	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:65293487G>C	uc001oea.1	+	3	425	c.348G>C	c.(346-348)GAG>GAC	p.E116D	SCYL1_uc009yqk.2_Missense_Mutation_p.E116D|SCYL1_uc001oeb.1_Missense_Mutation_p.E116D|SCYL1_uc001oec.1_Missense_Mutation_p.E116D|SCYL1_uc001oed.1_5'UTR	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	116	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						AGGAGCTGGAGATCTCCTGGG	0.607			NA											9	91					0	0	0.006214	0	0
KCNK7	10089	broad.mit.edu	37	11	65360568	65360568	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:65360568C>T	uc001oes.2	-	3	1056	c.832G>A	c.(832-834)GAG>AAG	p.E278K	KCNK7_uc001oeq.2_3'UTR|KCNK7_uc001oer.2_3'UTR|KCNK7_uc001oeu.2_3'UTR	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	278	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CCTTGGTCCTCAGCAGTCACA	0.627			NA											4	20					0	0	0.009096	0	0
FIBP	9158	broad.mit.edu	37	11	65655442	65655442	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:65655442G>T	uc001ogd.2	-	2	368	c.247C>A	c.(247-249)CAG>AAG	p.Q83K	FIBP_uc009yqu.2_Missense_Mutation_p.Q80K|FIBP_uc001oge.2_Missense_Mutation_p.Q83K|FIBP_uc010roq.1_Missense_Mutation_p.Q83K|FIBP_uc010ror.1_Missense_Mutation_p.Q83K|CCDC85B_uc001ogf.2_5'Flank	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	83					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		GGCGGAATCTGGAAGATGAGC	0.502			NA											7	25					0.000442599	0.000463444	0.006214	1	0
FCHSD2	9873	broad.mit.edu	37	11	72554227	72554227	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:72554227G>C	uc009ytl.2	-	16	1895	c.1674C>G	c.(1672-1674)CTC>CTG	p.L558L	FCHSD2_uc010rrg.1_Silent_p.L422L|FCHSD2_uc001oth.3_Silent_p.L502L|FCHSD2_uc001oti.2_Silent_p.L517L|ATG16L2_uc009ytj.1_3'UTR	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	558							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TGCCTGAAACGAGTTCTGCTT	0.522			NA											6	46					0	0	0.001168	0	0
ME3	10873	broad.mit.edu	37	11	86270746	86270746	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:86270746C>G	uc001pbz.2	-	2	557	c.303G>C	c.(301-303)CAG>CAC	p.Q101H	ME3_uc001pca.2_Missense_Mutation_p.Q101H|ME3_uc009yvk.2_Missense_Mutation_p.Q101H|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	101					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	CCAGGTCACTCTGCTGCCGCT	0.532			NA											31	145					0	0	0.003271	0	0
TYR	7299	broad.mit.edu	37	11	88911360	88911360	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:88911360G>T	uc001pcs.2	+	1	321	c.239G>T	c.(238-240)TGG>TTG	p.W80L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	80	Lumenal, melanosome (Potential).		W -> R (in OCA1A).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CGGGAGTCGTGGCCTTCCGTC	0.517			NA							Oculocutaneous_Albinism				36	11					6.84511e-11	7.76478e-11	0.003271	1	0
DYNC2H1	79659	broad.mit.edu	37	11	102980339	102980339	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:102980339C>T	uc001pho.2	+	1	180	c.36C>T	c.(34-36)TTC>TTT	p.F12F	DYNC2H1_uc001phn.1_Silent_p.F12F|DYNC2H1_uc009yxe.1_Silent_p.F12F	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	12	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GGAAGCTCTTCATCTTCACTA	0.517			NA											7	49					0	0	0.004482	0	0
CUL5	8065	broad.mit.edu	37	11	107965677	107965677	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:107965677G>T	uc001pjv.2	+	15	2373	c.1706G>T	c.(1705-1707)AGA>ATA	p.R569I	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	569					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		CATAGTGGTAGAAAATTACAT	0.303			NA											6	66					1.06961e-07	1.17728e-07	0.00308	1	0
EXPH5	23086	broad.mit.edu	37	11	108385075	108385075	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:108385075C>G	uc001pkk.2	-	6	1270	c.1159G>C	c.(1159-1161)GAG>CAG	p.E387Q	EXPH5_uc010rvy.1_Missense_Mutation_p.E199Q|EXPH5_uc010rvz.1_Missense_Mutation_p.E231Q|EXPH5_uc010rwa.1_Missense_Mutation_p.E311Q	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	387					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTCAGGAACTCTTCCTGGTTC	0.453			NA											12	244					0	0	0.00245	0	0
FEZ1	9638	broad.mit.edu	37	11	125359520	125359520	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:125359520C>T	uc001qbx.2	-	2	306	c.154G>A	c.(154-156)GAA>AAA	p.E52K	FEZ1_uc010sbc.1_Missense_Mutation_p.E52K|FEZ1_uc001qby.1_Missense_Mutation_p.E52K	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	52					axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		CTGATTATTTCGGAAGAAAAA	0.507	Melanoma(180;509 2033 10762 15939 24711)		NA											5	58					0	0	0.000602	0	0
STT3A	3703	broad.mit.edu	37	11	125483032	125483032	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:125483032T>A	uc001qcd.2	+	13	1624	c.1514T>A	c.(1513-1515)TTC>TAC	p.F505Y	STT3A_uc001qce.2_Missense_Mutation_p.F505Y|STT3A_uc010sbg.1_Missense_Mutation_p.F413Y|STT3A_uc009zbn.2_Missense_Mutation_p.F227Y	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	505	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TTTGATGACTTCCGAGAAGCA	0.483			NA											39	33					0	0	0.011902	0	0
PATE1	160065	broad.mit.edu	37	11	125618573	125618573	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:125618573A>G	uc001qct.2	+	5	338	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	PATE1_uc009zbr.2_Missense_Mutation_p.Y97C	NM_138294	NP_612151	Q8WXA2	PATE1_HUMAN	expressed in prostate and testis precursor	109						extracellular region					0						TGGAGTGTCTATTTGGTGAAC	0.468			NA											28	35					0	0	0.008361	0	0
FLI1	2313	broad.mit.edu	37	11	128628062	128628062	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:128628062G>A	uc010sbu.1	+	2	412	c.71G>A	c.(70-72)GGA>GAA	p.G24E	FLI1_uc010sbt.1_5'UTR|FLI1_uc010sbv.1_5'UTR|FLI1_uc009zci.2_5'UTR|FLI1_uc001qen.2_5'UTR	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	24					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		TCAGCGTACGGAGCGGCAGCC	0.627			NA	T	EWSR1	Ewing sarcoma								4	6					0	0	0.009096	0	0
PRDM10	56980	broad.mit.edu	37	11	129814802	129814802	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:129814802G>A	uc001qfm.2	-	6	858	c.626C>T	c.(625-627)CCC>CTC	p.P209L	PRDM10_uc001qfj.2_Missense_Mutation_p.P123L|PRDM10_uc001qfk.2_Missense_Mutation_p.P123L|PRDM10_uc001qfl.2_Missense_Mutation_p.P123L|PRDM10_uc010sbx.1_Missense_Mutation_p.P123L|PRDM10_uc001qfn.2_Missense_Mutation_p.P209L|PRDM10_uc009zct.1_Missense_Mutation_p.P241L	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	209	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GAGCACCAGGGGGAGGCTCGC	0.667			NA											17	20					0	0	0.007413	0	0
KDM5A	5927	broad.mit.edu	37	12	427406	427406	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:427406G>A	uc001qif.1	-	19	3126	c.2763C>T	c.(2761-2763)GTC>GTT	p.V921V	KDM5A_uc001qie.1_Silent_p.V921V|KDM5A_uc010sdn.1_Silent_p.V880V	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	921					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						GCTTCTTCATGACATCCAAAG	0.498			NA	T 	NUP98	AML								21	125					0	0	0.014323	0	0
WNK1	65125	broad.mit.edu	37	12	989170	989170	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:989170A>G	uc001qio.3	+	11	3312	c.2805A>G	c.(2803-2805)CCA>CCG	p.P935P	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	935					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTGAGGTTCCACTTTCCTCTG	0.478	Colon(19;451 567 6672 12618 28860)		NA											13	47					0	0	0.00245	0	0
MAGOHB	55110	broad.mit.edu	37	12	10766091	10766091	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:10766091C>A	uc001qyq.1	-	1	93	c.41G>T	c.(40-42)GGG>GTG	p.G14V	MAGOHB_uc001qyr.1_RNA	NM_018048	NP_060518	Q96A72	MGN2_HUMAN	mago-nashi homolog B	14					mRNA processing|mRNA transport|RNA splicing	nucleus	RNA binding			breast(1)	1						GCCCTTGTGCCCTACGTAGTA	0.612			NA											45	67					1.61863e-15	1.92104e-15	0.01441	1	0
CSDA	8531	broad.mit.edu	37	12	10865907	10865907	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:10865907C>T	uc001qyt.2	-	5	719	c.476G>A	c.(475-477)GGC>GAC	p.G159D	CSDA_uc001qyu.2_Missense_Mutation_p.G159D	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	159					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					TCCATCCGGGCCAGTCACATT	0.502			NA											50	77					0	0	0.01441	0	0
GRIN2B	2904	broad.mit.edu	37	12	13720004	13720004	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:13720004C>A	uc001rbt.2	-	12	2732	c.2553G>T	c.(2551-2553)ATG>ATT	p.M851I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	851	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AACAGACACCCATAAAGCAAT	0.498			NA											19	42					1.67942e-08	1.86384e-08	0.006122	1	0
ARHGDIB	397	broad.mit.edu	37	12	15095518	15095518	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:15095518C>T	uc001rcq.1	-	6	648	c.544G>A	c.(544-546)GAC>AAC	p.D182N	ARHGDIB_uc001rcp.1_RNA	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	182					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						TCTTGCTTGTCATCGTCGGTG	0.562			NA											20	115					0	0	0.012319	0	0
PTPRO	5800	broad.mit.edu	37	12	15637097	15637097	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:15637097C>T	uc001rcv.1	+	2	439	c.265C>T	c.(265-267)CAT>TAT	p.H89Y	PTPRO_uc001rcw.1_Missense_Mutation_p.H89Y|PTPRO_uc001rcu.1_Missense_Mutation_p.H89Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	89	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GGCCAGTTATCATGGCCTTTA	0.373			NA											9	50					0	0	0.006214	0	0
PTPRO	5800	broad.mit.edu	37	12	15637110	15637110	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:15637110A>T	uc001rcv.1	+	2	452	c.278A>T	c.(277-279)TAT>TTT	p.Y93F	PTPRO_uc001rcw.1_Missense_Mutation_p.Y93F|PTPRO_uc001rcu.1_Missense_Mutation_p.Y93F	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	93	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GGCCTTTATTATATAATCACT	0.373			NA											9	39					0	0	0.006214	0	0
RERGL	79785	broad.mit.edu	37	12	18234245	18234245	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:18234245G>A	uc001rdq.2	-	6	692	c.498C>T	c.(496-498)ATC>ATT	p.I166I	RERGL_uc001rdr.2_Silent_p.I165I	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	166	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TGATAATTCTGATAAACATCA	0.418			NA											11	60					0	0	0.010729	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	18					1.12685e-05	1.20838e-05	0.004482	1	0
BICD1	636	broad.mit.edu	37	12	32481160	32481160	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:32481160G>A	uc001rku.2	+	5	1852	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K	BICD1_uc001rkv.2_Missense_Mutation_p.E591K|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	591					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GGCCAGCAAAGAACCAAGTCC	0.498			NA											11	76					0	0	0.008291	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826425	43826426	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:43826425_43826426CC>AT	uc010skx.1	-	20	2909_2910	c.2909_2910GG>AT	c.(2908-2910)TGG>TAT	p.W970Y	ADAMTS20_uc001rno.1_Missense_Mutation_p.W124Y|ADAMTS20_uc001rnp.1_Missense_Mutation_p.W124Y	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	970	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGAATAATGCCATCTTGTGAA	0.371			NA											16	21					0	0	0.004672	0	0
POU6F1	5463	broad.mit.edu	37	12	51584196	51584196	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:51584196T>C	uc001rxy.2	-	5	932	c.740A>G	c.(739-741)GAG>GGG	p.E247G	POU6F1_uc001rxz.2_Missense_Mutation_p.E247G|POU6F1_uc001rya.2_Missense_Mutation_p.E247G	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	247	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATTGAGAGCCTCTATGGCCTG	0.572			NA											6	120					0	0	0.001168	0	0
KRT80	144501	broad.mit.edu	37	12	52574327	52574327	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:52574327G>A	uc001rzx.2	-	4	734	c.636C>T	c.(634-636)TTC>TTT	p.F212F	KRT80_uc001rzw.2_Silent_p.F247F|KRT80_uc001rzy.2_Silent_p.F212F	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	212	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		TCAACTCCACGAAGCTCTCCA	0.547	GBM(178;2309 2916 15678 35873)		NA											26	105					0	0	0.004656	0	0
KRT75	9119	broad.mit.edu	37	12	52824329	52824329	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:52824329G>C	uc001saj.2	-	5	1053	c.1031C>G	c.(1030-1032)ACC>AGC	p.T344S		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	344	Coil 2.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GCTCACCTTGGTCTGGTACCA	0.542			NA											51	71					0	0	0.01441	0	0
TENC1	23371	broad.mit.edu	37	12	53457028	53457028	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:53457028G>A	uc001sbp.2	+	26	4114	c.3979G>A	c.(3979-3981)GAC>AAC	p.D1327N	TENC1_uc001sbl.2_Missense_Mutation_p.D1203N|TENC1_uc001sbn.2_Missense_Mutation_p.D1337N|TENC1_uc001sbq.2_Missense_Mutation_p.D725N|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Missense_Mutation_p.D820N|TENC1_uc001sbs.2_Missense_Mutation_p.D146N	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1327					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						TACACTGACGGACAACCAAAG	0.582			NA											18	55					0	0	0.008871	0	0
MFSD5	84975	broad.mit.edu	37	12	53647661	53647661	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:53647661C>T	uc001sci.1	+	2	1233	c.1042C>T	c.(1042-1044)CTA>TTA	p.L348L	MFSD5_uc001sch.1_Silent_p.L455L	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	348	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						CATAGCCTTTCTACTTATTGA	0.507			NA											18	83					0	0	0.007413	0	0
GLI1	2735	broad.mit.edu	37	12	57863408	57863408	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:57863408C>G	uc001snx.2	+	11	1581	c.1503C>G	c.(1501-1503)CTC>CTG	p.L501L	GLI1_uc009zpq.2_Silent_p.L373L	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	501					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TTGAGAACCTCAGGCTGGACC	0.617	Pancreas(157;841 1936 10503 41495 50368)		NA											19	58					0	0	0.008871	0	0
NAV3	89795	broad.mit.edu	37	12	78452786	78452786	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:78452786G>C	uc001syp.2	+	12	2700	c.2527G>C	c.(2527-2529)GAT>CAT	p.D843H	NAV3_uc001syo.2_Missense_Mutation_p.D843H|NAV3_uc010sub.1_Missense_Mutation_p.D343H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	843						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GTACATGACAGATGGAGGACT	0.388			NA								HNSCC(70;0.22)			15	34					0	0	0.00499	0	0
NAV3	89795	broad.mit.edu	37	12	78562540	78562540	+	Silent	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:78562540T>A	uc001syp.2	+	24	5048	c.4875T>A	c.(4873-4875)TCT>TCA	p.S1625S	NAV3_uc001syo.2_Silent_p.S1625S|NAV3_uc010sub.1_Silent_p.S1111S|NAV3_uc009zsf.2_Silent_p.S456S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1625	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CACAGGAATCTGAACTTATAG	0.403			NA								HNSCC(70;0.22)			21	47					0	0	0.012319	0	0
GALNT4	8693	broad.mit.edu	37	12	89917428	89917428	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:89917428C>G	uc001tbd.2	-	1	1108	c.899G>C	c.(898-900)AGA>ACA	p.R300T	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Missense_Mutation_p.R297T|GALNT4_uc010suo.1_5'UTR	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	300	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						GGGGTCAATTCTTGATATCCG	0.468			NA											18	73					0	0	0.007413	0	0
HAL	3034	broad.mit.edu	37	12	96389479	96389479	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:96389479G>C	uc001tem.1	-	2	507	c.210C>G	c.(208-210)CTC>CTG	p.L70L	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Silent_p.L70L	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	70					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	GGGCCACCTCGAGCCGGTCCT	0.622	NSCLC(169;943 2815 23563 30031)		NA											22	27					0	0	0.00333	0	0
ACAD10	80724	broad.mit.edu	37	12	112153654	112153654	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:112153654G>A	uc001tsq.2	+	7	1080	c.880G>A	c.(880-882)GGG>AGG	p.G294R	ACAD10_uc001tso.3_Intron|ACAD10_uc001tsp.2_Missense_Mutation_p.G294R|ACAD10_uc009zvx.2_Missense_Mutation_p.G325R|ACAD10_uc001tsr.2_Missense_Mutation_p.G32R|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	294							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GTTTGATCACGGGCAGTCAAA	0.473			NA											38	103					0	0	0.006999	0	0
RASAL1	8437	broad.mit.edu	37	12	113565663	113565663	+	Silent	SNP	G	G	A	rs61759864	byFrequency	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:113565663G>A	uc001tum.1	-	5	545	c.252C>T	c.(250-252)ATC>ATT	p.I84I	RASAL1_uc010syp.1_Silent_p.I84I|RASAL1_uc001tul.2_Silent_p.I84I|RASAL1_uc001tun.1_Silent_p.I84I|RASAL1_uc010syq.1_Silent_p.I84I|RASAL1_uc001tuo.3_Silent_p.I84I|RASAL1_uc010syr.1_Silent_p.I84I	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	84	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGATCTTGCCGATGATGTCGT	0.662			NA											7	77					0	0	0.001984	0	0
ORAI1	84876	broad.mit.edu	37	12	122064796	122064796	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:122064796C>G	uc010szz.1	+	2	336	c.143C>G	c.(142-144)TCC>TGC	p.S48C		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	48	Cytoplasmic (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		ccgccgccgtccgccgtcacc	0.363			NA											5	16					0	0	0.000602	0	0
WDR66	144406	broad.mit.edu	37	12	122396299	122396299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:122396299C>T	uc009zxk.2	+	12	1994	c.1852C>T	c.(1852-1854)CAA>TAA	p.Q618*		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	618	WD 6.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CCACCCATATCAACCCCTCAT	0.463	Esophageal Squamous(85;849 1794 49757 52143)		NA											30	122					0	0	0.008361	0	0
MLXIP	22877	broad.mit.edu	37	12	122623049	122623049	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:122623049G>A	uc001ubq.2	+	14	2335	c.2335G>A	c.(2335-2337)GAG>AAG	p.E779K	MLXIP_uc001ubt.2_Missense_Mutation_p.E386K	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	779	Leucine-zipper.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GATGCAGGAGGAGGCCCGGCG	0.627	Esophageal Squamous(105;787 1493 16200 18566 52466)		NA											8	21					0	0	0.00308	0	0
VPS37B	79720	broad.mit.edu	37	12	123380591	123380591	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:123380591C>T	uc001udl.2	-	1	122	c.19G>A	c.(19-21)GAA>AAA	p.E7K		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	7					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		AACCGGGCTTCGCTCCCGGCG	0.692			NA											4	51					0	0	0.009096	0	0
DNAH10	196385	broad.mit.edu	37	12	124330325	124330325	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:124330325C>T	uc001uft.3	+	30	5210	c.5185C>T	c.(5185-5187)CCG>TCG	p.P1729S		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1729	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CATCACCATGCCGCTAAGCAA	0.463			NA											23	42					0	0	0.00278	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559035	129559035	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:129559035G>A	uc009zyl.1	-	9	3013	c.2685C>T	c.(2683-2685)CCC>CCT	p.P895P	TMEM132D_uc001uia.2_Silent_p.P433P	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	895	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CATTGCTTCTGGGGAGGTCCA	0.517			NA											17	62					0	0	0.007413	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184802	130184802	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:130184802C>T	uc009zyl.1	-	2	849	c.521G>A	c.(520-522)CGA>CAA	p.R174Q		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	174	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCGGGTCTCTCGGAAAGCAAA	0.682			NA											4	18					0	0	0.009096	0	0
PIWIL1	9271	broad.mit.edu	37	12	130842061	130842061	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:130842061G>A	uc001uik.2	+	14	1718	c.1628G>A	c.(1627-1629)AGA>AAA	p.R543K	PIWIL1_uc001uij.1_Missense_Mutation_p.R543K	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	543	RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GCCTACTTAAGAGTCTTACAG	0.423			NA											18	62					0	0	0.014323	0	0
GOLGA3	2802	broad.mit.edu	37	12	133365817	133365817	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr12:133365817C>T	uc001ukz.1	-	13	3166	c.2607G>A	c.(2605-2607)CTG>CTA	p.L869L	GOLGA3_uc001ula.1_Silent_p.L869L|GOLGA3_uc001ulb.2_Silent_p.L869L	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	869	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGGTGGCTTTCAGCTCACTGA	0.657			NA											11	42					0	0	0.010729	0	0
BRCA2	675	broad.mit.edu	37	13	32968918	32968918	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:32968918C>A	uc001uub.1	+	25	9576	c.9349C>A	c.(9349-9351)CAT>AAT	p.H3117N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3117					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TATTAAGCCTCATATGTTAAT	0.398	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			7	28					2.7689e-08	3.06278e-08	0.001984	1	0
INTS6	26512	broad.mit.edu	37	13	51963515	51963515	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:51963515C>A	uc001vfk.2	-	6	1293	c.679G>T	c.(679-681)GTA>TTA	p.V227L	INTS6_uc001vfj.2_Missense_Mutation_p.V214L|INTS6_uc001vfl.2_Missense_Mutation_p.V49L	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	227	VWFA.				snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		CCACTTTGTACTTTCTGCACC	0.348			NA											39	111					1.97e-11	2.25771e-11	0.010771	1	0
PCDH9	5101	broad.mit.edu	37	13	67802282	67802282	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:67802282G>C	uc001vik.2	-	2	983	c.291C>G	c.(289-291)CTC>CTG	p.L97L	PCDH9_uc001vil.2_Silent_p.L97L|PCDH9_uc010thl.1_Silent_p.L97L|PCDH9_uc001vin.3_Silent_p.L97L	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	97	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CGCCAGCACAGAGTTTTTCTC	0.438			NA											12	44					0	0	0.001855	0	0
KLF5	688	broad.mit.edu	37	13	73636220	73636220	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:73636220C>G	uc001vje.2	+	2	807	c.483C>G	c.(481-483)ATC>ATG	p.I161M	KLF5_uc001vjd.2_Missense_Mutation_p.I70M	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	161					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TAACACACATCAAGACAGAAC	0.527			NA											8	91					0	0	0.00308	0	0
ITGBL1	9358	broad.mit.edu	37	13	102250648	102250648	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:102250648G>T	uc001vpb.2	+	7	1233	c.1014G>T	c.(1012-1014)AGG>AGT	p.R338S	ITGBL1_uc010agb.2_Missense_Mutation_p.R289S|ITGBL1_uc001vpc.3_Missense_Mutation_p.R197S	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	338	VII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCTCTGGGAGGGGTAAGTGAG	0.473			NA											14	15					4.3838e-07	4.78559e-07	0.001855	1	0
IRS2	8660	broad.mit.edu	37	13	110435157	110435157	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr13:110435157T>G	uc001vqv.2	-	1	3758	c.3244A>C	c.(3244-3246)ACC>CCC	p.T1082P		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1082					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TGCGGCGGGGTGGCGGCCACA	0.637	Melanoma(100;613 2409 40847)		NA											3	4					0	0	0.001984	0	0
OR11G2	390439	broad.mit.edu	37	14	20665870	20665870	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:20665870G>C	uc010tlb.1	+	1	376	c.376G>C	c.(376-378)GAC>CAC	p.D126H		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	126	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTTCCTCTCTGACACCAAGAT	0.498			NA											12	49					0	0	0.010729	0	0
OR4E2	26686	broad.mit.edu	37	14	22133623	22133623	+	Silent	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:22133623T>C	uc010tmd.1	+	1	327	c.327T>C	c.(325-327)TGT>TGC	p.C109C		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TCTTTGCCTGTGCCGAGATCT	0.453			NA											8	211					0	0	0.00308	0	0
EFS	10278	broad.mit.edu	37	14	23828666	23828666	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:23828666G>T	uc001wjo.2	-	4	1629	c.1021C>A	c.(1021-1023)CCA>ACA	p.P341T	EFS_uc001wjp.2_Missense_Mutation_p.P248T|EFS_uc010tnm.1_Missense_Mutation_p.P172T	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	341	SH3-binding (Potential).|Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		AGGCGGGGTGGGGGTGGGGGC	0.701			NA											35	20					6.05902e-23	7.42898e-23	0.003755	1	0
Unknown	0	broad.mit.edu	37	14	28733949	28733949	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:28733949T>A	uc001wqd.2	+	1	330	c.190T>A	c.(190-192)TGT>AGT	p.C64S						SubName: Full=cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;												NA						GAGTTCTCACTGTGACAGCCC	0.478			NA											40	29					0	0	0.011902	0	0
HECTD1	25831	broad.mit.edu	37	14	31597041	31597041	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:31597041G>C	uc001wrc.1	-	26	5420	c.4931C>G	c.(4930-4932)TCA>TGA	p.S1644*	HECTD1_uc001wrb.1_Translation_Start_Site|HECTD1_uc001wrd.1_Nonsense_Mutation_p.S1112*	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1644	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACTGGAAGTTGATGTGAGGCT	0.363			NA											34	146					0	0	0.006999	0	0
ARHGAP5	394	broad.mit.edu	37	14	32624150	32624150	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:32624150T>C	uc001wrl.2	+	7	4744	c.4505T>C	c.(4504-4506)ATA>ACA	p.I1502T	ARHGAP5_uc001wrm.2_Missense_Mutation_p.I1501T|ARHGAP5_uc001wrn.2_Missense_Mutation_p.I1502T|ARHGAP5_uc001wro.2_Missense_Mutation_p.I241T|ARHGAP5_uc001wrp.2_Missense_Mutation_p.I237T	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1502					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTTGGTATTATATGAGTAGGA	0.433	NSCLC(9;77 350 3443 29227 41353)		NA											61	52					0	0	0.01441	0	0
PAX9	5083	broad.mit.edu	37	14	37132112	37132112	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:37132112C>A	uc001wty.3	+	3	732	c.15C>A	c.(13-15)TTC>TTA	p.F5L		NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	5	Paired.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		AGCCAGCCTTCGGGGAGGTGA	0.662			NA											20	127					1.55795e-14	1.82627e-14	0.012319	1	0
FOXA1	3169	broad.mit.edu	37	14	38060627	38060627	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:38060627G>A	uc001wuf.2	-	2	1674	c.1362C>T	c.(1360-1362)GCC>GCT	p.A454A	FOXA1_uc010tpz.1_Silent_p.A421A	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	454					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CCGGCTCCAGGGCTGAGGGCT	0.617			NA											14	128					0	0	0.003163	0	0
FAM179B	23116	broad.mit.edu	37	14	45431916	45431916	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:45431916C>G	uc001wvv.2	+	1	501	c.292C>G	c.(292-294)CGG>GGG	p.R98G	FAM179B_uc001wvw.2_Missense_Mutation_p.R98G|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R98G|FAM179B_uc001wvu.2_Missense_Mutation_p.R98G	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	98							binding			skin(2)|upper_aerodigestive_tract(1)	3						AGAGGACACTCGGCTCCTTCA	0.642			NA											7	116					0	0	0.001984	0	0
TRIM9	114088	broad.mit.edu	37	14	51467560	51467560	+	Splice_Site	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:51467560T>C	uc001wyx.3	-	6	2072	c.1307_splice	c.e6-1	p.A436_splice	TRIM9_uc001wyy.2_Intron|TRIM9_uc001wyz.3_Splice_Site_p.A436_splice	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1						proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					GAGAGGAAGCTAAACAGAAAT	0.473			NA											7	56					0	0	0.004482	0	0
FBXO34	55030	broad.mit.edu	37	14	55817174	55817174	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:55817174G>A	uc001xbu.2	+	2	311	c.66G>A	c.(64-66)ACG>ACA	p.T22T	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Silent_p.T22T	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	22										ovary(2)|lung(2)|skin(1)	5						GCAGGGAAACGCAGAGAACTC	0.448			NA											6	64					0	0	0.001168	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68273273	68273273	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:68273273C>G	uc001xka.2	-	6	1145	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.E336Q|ZFYVE26_uc010tta.1_Missense_Mutation_p.E336Q	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	336					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGAATCTGCTCGAGGAAGTGT	0.498			NA											15	31					0	0	0.00245	0	0
ESRRB	2103	broad.mit.edu	37	14	76906018	76906018	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:76906018G>T	uc001xsq.1	+	2	389	c.322G>T	c.(322-324)GAC>TAC	p.D108Y	ESRRB_uc001xsr.2_Missense_Mutation_p.D108Y|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	108						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CGTGTGCGGGGACATTGCCTC	0.617			NA											25	9					1.64293e-13	1.91245e-13	0.00333	1	0
ALKBH1	8846	broad.mit.edu	37	14	78161119	78161119	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:78161119C>G	uc001xuc.1	-	3	426	c.417G>C	c.(415-417)GAG>GAC	p.E139D	ALKBH1_uc001xud.1_Intron	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	139					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		GATCTTGGGTCTCTTCTTTAG	0.428			NA											38	165					0	0	0.007835	0	0
DIO2	1734	broad.mit.edu	37	14	80669079	80669079	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:80669079C>A	uc010tvq.1	-	4	1177	c.775G>T	c.(775-777)GAG>TAG	p.E259*	DIO2_uc010tvp.1_Nonsense_Mutation_p.E295*|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Nonsense_Mutation_p.E259*|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	259					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		AAATTCTTCTCCAGCCAATGC	0.398			NA											15	10					8.60227e-14	1.0031e-13	0.004007	1	0
BTBD7	55727	broad.mit.edu	37	14	93720129	93720129	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:93720129C>G	uc001ybo.2	-	7	1942	c.1616G>C	c.(1615-1617)AGA>ACA	p.R539T	BTBD7_uc010aur.2_Missense_Mutation_p.R64T|BTBD7_uc010two.1_Missense_Mutation_p.R359T|BTBD7_uc001ybp.2_Missense_Mutation_p.R188T	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	539										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		AATCAAGCCTCTTTTCATCta	0.284			NA											8	41					0	0	0.00308	0	0
OTUD7A	161725	broad.mit.edu	37	15	31776389	31776389	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:31776389T>A	uc001zfq.2	-	11	1982	c.1889A>T	c.(1888-1890)CAG>CTG	p.Q630L	OTUD7A_uc001zfr.2_Missense_Mutation_p.Q637L	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	630						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GCGCTCCCCCTGCATGGCGGC	0.682			NA											4	10					0	0	0.009096	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32917434	32917434	+	Silent	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:32917434A>T	uc001zgy.1	+	5	1427	c.705A>T	c.(703-705)GCA>GCT	p.A235A	ARHGAP11A_uc010ubw.1_Silent_p.A46A|ARHGAP11A_uc001zgw.2_Silent_p.A235A|ARHGAP11A_uc001zgx.2_Silent_p.A235A|ARHGAP11A_uc010ubx.1_Silent_p.A46A	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	235	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TCGATTATGCATCAGATATTG	0.343	Colon(45;757 1134 30003 36652)		NA											8	19					0	0	0.00308	0	0
RYR3	6263	broad.mit.edu	37	15	34018589	34018589	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:34018589C>A	uc001zhi.2	+	46	6985	c.6915C>A	c.(6913-6915)CTC>CTA	p.L2305L	RYR3_uc010bar.2_Silent_p.L2305L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2305	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTTCCAGCTCATCCAGACAG	0.547			NA											6	12					0.00198382	0.00205467	0.001984	1	0
PLCB2	5330	broad.mit.edu	37	15	40589781	40589781	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:40589781C>G	uc001zld.2	-	13	1565	c.1264G>C	c.(1264-1266)GAG>CAG	p.E422Q	PLCB2_uc010bbo.2_Missense_Mutation_p.E422Q|PLCB2_uc010ucm.1_Missense_Mutation_p.E422Q	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	422	PI-PLC X-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CGGCAATACTCAGCCATCTTA	0.577			NA											10	26					0	0	0.006214	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434260	42434260	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:42434260C>T	uc001zoz.2	-	20	2535	c.2472G>A	c.(2470-2472)CTG>CTA	p.L824L	PLA2G4F_uc010bcq.2_Silent_p.L121L|PLA2G4F_uc001zoy.2_Silent_p.L456L|PLA2G4F_uc010bcr.2_Silent_p.L575L|PLA2G4F_uc001zpa.2_Silent_p.L575L|PLA2G4F_uc010bcs.2_Silent_p.L611L	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	824	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CCACGTTGTTCAGGACGTTGT	0.597			NA											12	36					0	0	0.013537	0	0
TP53BP1	7158	broad.mit.edu	37	15	43701917	43701917	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:43701917G>C	uc001zrs.2	-	25	5461	c.5313C>G	c.(5311-5313)TTC>TTG	p.F1771L	TP53BP1_uc010udp.1_Missense_Mutation_p.F1769L|TP53BP1_uc001zrq.3_Missense_Mutation_p.F1774L|TP53BP1_uc001zrr.3_Missense_Mutation_p.F1776L|TP53BP1_uc001zrp.2_Missense_Mutation_p.F188L	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1771	BRCT 1.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ACTGCTTGTTGAAAGGAGGAA	0.363			NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					4	11					0	0	0.009096	0	0
SLC12A1	6557	broad.mit.edu	37	15	48551426	48551426	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:48551426C>A	uc001zwn.3	+	17	2288	c.2072C>A	c.(2071-2073)CCC>CAC	p.P691H	SLC12A1_uc010uew.1_Missense_Mutation_p.P497H|SLC12A1_uc010bem.2_Missense_Mutation_p.P691H|SLC12A1_uc001zwq.3_Missense_Mutation_p.P462H|SLC12A1_uc001zwr.3_Missense_Mutation_p.P418H	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	691					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ACAGGGGGACCCATGACAAGA	0.493			NA											22	83					4.26978e-12	4.90179e-12	0.00333	1	0
SCG3	29106	broad.mit.edu	37	15	51975452	51975452	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:51975452A>T	uc002abh.2	+	4	626	c.218A>T	c.(217-219)GAT>GTT	p.D73V	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	73					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		TCTTTTGTTGATAACTTGAAC	0.363			NA											65	102					0	0	0.01441	0	0
PARP6	56965	broad.mit.edu	37	15	72554009	72554009	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:72554009C>G	uc002auc.2	-	8	894	c.435G>C	c.(433-435)CTG>CTC	p.L145L	PARP6_uc002aua.2_Silent_p.L10L|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Silent_p.L145L	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	145							NAD+ ADP-ribosyltransferase activity				0						AATCATTGCTCAGATGTTTCC	0.458			NA											51	224					0	0	0.01441	0	0
SIN3A	25942	broad.mit.edu	37	15	75687143	75687143	+	Missense_Mutation	SNP	C	C	T	rs151089140		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:75687143C>T	uc002bai.2	-	14	2414	c.2155G>A	c.(2155-2157)GAA>AAA	p.E719K	SIN3A_uc002baj.2_Missense_Mutation_p.E719K|SIN3A_uc010uml.1_Missense_Mutation_p.E719K	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	719	Interactions with HDAC1 and ARID4B.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TCATTTTGTTCTCGCCATACT	0.438			NA											19	123					0	0	0.010504	0	0
CSPG4	1464	broad.mit.edu	37	15	75968709	75968709	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:75968709C>A	uc002baw.2	-	10	6244	c.6151G>T	c.(6151-6153)GCA>TCA	p.A2051S		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	2051	Extracellular (Potential).|CSPG 15.|Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGCCCACCTGCCCACACATGC	0.647			NA											6	26					0.00116845	0.00121774	0.001168	1	0
ACSBG1	23205	broad.mit.edu	37	15	78526821	78526821	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:78526821C>T	uc002bdh.2	-	1	79	c.23G>A	c.(22-24)GGA>GAA	p.G8E	ACSBG1_uc010umw.1_Missense_Mutation_p.G8E|ACSBG1_uc010umx.1_5'UTR|ACSBG1_uc010umy.1_5'UTR	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	8					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GCAGCCGTATCCAGCTCCAGA	0.597			NA											69	118					0	0	0.01441	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921577	78921577	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:78921577G>T	uc002bed.1	-	5	1182	c.1070C>A	c.(1069-1071)GCC>GAC	p.A357D	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.A175D	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	357	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GAAGGCTCTGGCCGGGCTGCT	0.637			NA											15	20					1.15088e-07	1.26464e-07	0.004007	1	0
AKAP13	11214	broad.mit.edu	37	15	86122855	86122855	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:86122855C>G	uc002blv.1	+	7	1726	c.1556C>G	c.(1555-1557)TCT>TGT	p.S519C	AKAP13_uc002blt.1_Missense_Mutation_p.S519C|AKAP13_uc002blu.1_Missense_Mutation_p.S519C	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	519					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCTGGAGCCTCTGACGTGCAC	0.483	Melanoma(94;603 1453 3280 32295 32951)		NA											9	54					0	0	0.004482	0	0
PLIN1	5346	broad.mit.edu	37	15	90213226	90213226	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:90213226C>G	uc010upx.1	-	5	693	c.583G>C	c.(583-585)GAC>CAC	p.D195H	PLIN1_uc002boh.2_Missense_Mutation_p.D195H	NM_001145311	NP_001138783	O60240	PLIN1_HUMAN	perilipin 1	195					triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2						TCTTCCTTGTCTGGAGGGAGG	0.602			NA											7	12					0	0	0.00308	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007521	93007521	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr15:93007521C>A	uc002bra.2	+	6	1189	c.1034C>A	c.(1033-1035)CCG>CAG	p.P345Q	ST8SIA2_uc002brb.2_Missense_Mutation_p.P324Q	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	345	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CAGGCCAGCCCGCATACCATG	0.572			NA											30	60					0.00209593	0.00216742	0.010818	1	0
RAB11FIP3	9727	broad.mit.edu	37	16	532599	532599	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:532599G>A	uc002chf.2	+	4	1317	c.978G>A	c.(976-978)GAG>GAA	p.E326E	RAB11FIP3_uc010uuf.1_Silent_p.E30E|RAB11FIP3_uc010uug.1_Silent_p.E16E	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	326					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				TCACGGACGAGGACACCAGCA	0.652	Melanoma(160;2366 2595 4474 8099)		NA											8	47					0	0	0.00308	0	0
CCNF	899	broad.mit.edu	37	16	2481210	2481210	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:2481210C>G	uc002cqd.1	+	2	184	c.96C>G	c.(94-96)ATC>ATG	p.I32M	CCNF_uc002cqe.1_Translation_Start_Site	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	32	F-box.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				ACCTGACCATCTTGAGTCTCC	0.478			NA											11	81					0	0	0.010729	0	0
A2BP1	54715	broad.mit.edu	37	16	7645563	7645563	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:7645563G>A	uc002cys.2	+	8	1469	c.481G>A	c.(481-483)GTA>ATA	p.V161I	A2BP1_uc010buf.1_Missense_Mutation_p.V161I|A2BP1_uc002cyr.1_Missense_Mutation_p.V160I|A2BP1_uc002cyt.2_Missense_Mutation_p.V161I|A2BP1_uc010uxz.1_Missense_Mutation_p.V204I|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Missense_Mutation_p.V161I|A2BP1_uc010uyb.1_Missense_Mutation_p.V161I|A2BP1_uc002cyw.2_Missense_Mutation_p.V181I|A2BP1_uc002cyy.2_Missense_Mutation_p.V181I|A2BP1_uc002cyx.2_Missense_Mutation_p.V181I|A2BP1_uc010uyc.1_Missense_Mutation_p.V181I	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	161	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		ATTTGGTTTCGTAACTTTCGA	0.443			NA											30	163					0	0	0.010818	0	0
OTOA	146183	broad.mit.edu	37	16	21709155	21709155	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:21709155C>T	uc002djh.2	+	9	800	c.799C>T	c.(799-801)CAC>TAC	p.H267Y	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.H188Y	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	267					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		ATACATGGTTCACCTATCGTT	0.313			NA											12	78					0	0	0.010729	0	0
KIAA0556	23247	broad.mit.edu	37	16	27772844	27772844	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:27772844A>G	uc002dow.2	+	19	3766	c.3742A>G	c.(3742-3744)ATC>GTC	p.I1248V		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1248										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CCTGCACCAGATCTCTGCTTC	0.577			NA											17	35					0	0	0.006122	0	0
APOB48R	55911	broad.mit.edu	37	16	28507384	28507384	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:28507384C>T	uc002dqb.1	+	2	1032	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	341	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GGGATAGCCTCAGGCGGGGAG	0.721			NA											3	15					0	0	0.004672	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31488304	31488304	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:31488304C>G	uc002ecd.1	+	10	1118	c.1092C>G	c.(1090-1092)CTC>CTG	p.L364L	TGFB1I1_uc002ece.1_Silent_p.L347L|TGFB1I1_uc010caq.1_Silent_p.L203L	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	364	LIM zinc-binding 3.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						TCAGCGCGCTCTGGCACCCGG	0.716			NA											3	8					0	0	0.004672	0	0
AHSP	51327	broad.mit.edu	37	16	31539514	31539514	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:31539514C>G	uc002ecj.2	+	2	139	c.54C>G	c.(52-54)TTC>TTG	p.F18L		NM_016633	NP_057717	Q9NZD4	AHSP_HUMAN	erythroid associated factor	18					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding				0						TGAAGGAGTTCAGCGTTCTGC	0.498			NA											12	73					0	0	0.010729	0	0
AMFR	267	broad.mit.edu	37	16	56423102	56423102	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:56423102A>C	uc002eiy.2	-	9	1476	c.1271T>G	c.(1270-1272)TTC>TGC	p.F424C	AMFR_uc002eix.2_Intron	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	424					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						CTAACCATCGAAATGGAAGAA	0.418	Pancreas(2;144 323 39528)		NA											9	52					0	0	0.008291	0	0
C16orf57	79650	broad.mit.edu	37	16	58051280	58051280	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:58051280C>G	uc002emz.2	+	5	629	c.546C>G	c.(544-546)TTC>TTG	p.F182L	C16orf57_uc010vib.1_Missense_Mutation_p.F164L	NM_024598	NP_078874	Q9BQ65	CP057_HUMAN	hypothetical protein LOC79650	182											0						ATGCCCAGTTCCTGGACCTGG	0.522			NA											5	66					0	0	0.000602	0	0
CDH8	1006	broad.mit.edu	37	16	61761011	61761011	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:61761011C>A	uc002eog.1	-	9	1775	c.1523G>T	c.(1522-1524)GGA>GTA	p.G508V	CDH8_uc002eoh.2_Missense_Mutation_p.G277V	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	508	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCCGGGTTTTCCATTTTCACA	0.378			NA											34	66					3.21399e-22	3.9048e-22	0.004878	1	0
FHOD1	29109	broad.mit.edu	37	16	67281227	67281227	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:67281227G>C	uc002esl.2	-	1	199	c.87C>G	c.(85-87)TTC>TTG	p.F29L	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR|SLC9A5_uc002esm.2_5'Flank|SLC9A5_uc010cee.2_5'Flank|SLC9A5_uc010vji.1_5'Flank	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	29					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TGGCACATGCGAAGGGGTCGG	0.721			NA											15	18					0	0	0.00499	0	0
SF3B3	23450	broad.mit.edu	37	16	70566441	70566441	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:70566441C>G	uc002ezf.2	+	5	841	c.630C>G	c.(628-630)TTC>TTG	p.F210L		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	210					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CACTTACTTTCTATGAGCTAG	0.393			NA											10	92					0	0	0.008291	0	0
IRF8	3394	broad.mit.edu	37	16	85936694	85936695	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:85936694_85936695GG>TT	uc002fjh.2	+	2	130_131	c.73_74GG>TT	c.(73-75)GGA>TTA	p.G25L	IRF8_uc002fji.2_Missense_Mutation_p.G25L	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	25	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				CATGTATCCAGGACTGATTTGG	0.49			NA											33	66					0	0	0.004672	0	0
ACSF3	197322	broad.mit.edu	37	16	89180750	89180750	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr16:89180750G>A	uc002fmp.2	+	6	1321	c.981G>A	c.(979-981)CTG>CTA	p.L327L	ACSF3_uc010cig.1_Silent_p.L327L|ACSF3_uc010cih.1_Silent_p.L62L|ACSF3_uc002fmq.1_Intron|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_Silent_p.L62L	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	327					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		CGCGTAGGCTGATGGTCTCAG	0.627			NA											16	51					0	0	0.00499	0	0
P2RX5	5026	broad.mit.edu	37	17	3592883	3592883	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:3592883G>A	uc002fwi.2	-	7	940	c.656C>T	c.(655-657)TCA>TTA	p.S219L	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.S218L|P2RX5_uc010vrx.1_Missense_Mutation_p.S159L|P2RX5_uc002fwj.2_Missense_Mutation_p.S194L|P2RX5_uc002fwk.2_Missense_Mutation_p.S218L|P2RX5_uc002fwl.2_Missense_Mutation_p.S195L	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	219	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						AAAGTGGCATGATTTCAGGAA	0.567			NA											22	86					0	0	0.005443	0	0
ITGAE	3682	broad.mit.edu	37	17	3661042	3661042	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:3661042G>C	uc002fwo.3	-	9	1077	c.978C>G	c.(976-978)ATC>ATG	p.I326M		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	326	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TGGGGGAGTTGATGACTGTCG	0.582	NSCLC(182;635 2928 8995 38788)		NA											45	153					0	0	0.01441	0	0
GP1BA	2811	broad.mit.edu	37	17	4835987	4835987	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:4835987G>C	uc010vsq.1	+	2	163	c.88G>C	c.(88-90)GAA>CAA	p.E30Q	uc002fzn.1_RNA	NM_000173	NP_000164	P07359	GP1BA_HUMAN	platelet glycoprotein Ib alpha polypeptide	30											0						CAGCCACCTAGAAGTGAACTG	0.577			NA											22	92					0	0	0.00333	0	0
AIPL1	23746	broad.mit.edu	37	17	6329120	6329120	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:6329120C>G	uc002gcp.2	-	6	910	c.815G>C	c.(814-816)CGG>CCG	p.R272P	AIPL1_uc002gcq.2_Missense_Mutation_p.R212P|AIPL1_uc002gcr.2_Missense_Mutation_p.R209P|AIPL1_uc010clk.2_Missense_Mutation_p.R250P|AIPL1_uc010cll.2_Missense_Mutation_p.R248P|AIPL1_uc002gcs.2_3'UTR	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	272	TPR 3.				protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		TGCGTGAGCCCGGGCACGCAC	0.667			NA											4	19					0	0	0.000602	0	0
ACADVL	37	broad.mit.edu	37	17	7126511	7126511	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:7126511C>G	uc002gev.2	+	11	1288	c.1137C>G	c.(1135-1137)ATC>ATG	p.I379M	ACADVL_uc010vtp.1_Missense_Mutation_p.I389M|ACADVL_uc010vtq.1_3'UTR|ACADVL_uc002gew.2_Missense_Mutation_p.I357M|ACADVL_uc002gex.2_Missense_Mutation_p.I303M	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	379	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TTGGGCTGATCCAGGAGAAGC	0.557			NA											4	67					0	0	0.000602	0	0
CHD3	1107	broad.mit.edu	37	17	7794291	7794291	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:7794291C>G	uc002gje.2	+	4	568	c.418C>G	c.(418-420)CTG>GTG	p.L140V	CHD3_uc002gjd.2_Missense_Mutation_p.L199V|CHD3_uc002gjf.2_Missense_Mutation_p.L140V|CHD3_uc002gjg.1_5'UTR	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	140					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				AACTCTGCTTCTGACCTGGGG	0.562			NA											27	91					0	0	0.009535	0	0
MYH13	8735	broad.mit.edu	37	17	10265786	10265786	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:10265786A>T	uc002gmk.1	-	4	329	c.239T>A	c.(238-240)ATG>AAG	p.M80K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	80	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGGAGGGTTCATGGGGAAGAC	0.488			NA											23	87					0	0	0.005443	0	0
DNAH9	1770	broad.mit.edu	37	17	11757715	11757715	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:11757715G>T	uc002gne.2	+	50	9971	c.9903G>T	c.(9901-9903)GAG>GAT	p.E3301D	DNAH9_uc010coo.2_Missense_Mutation_p.E2595D	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3301	Stalk (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGCCCAGGAGAAGCTGGCTG	0.547			NA											14	18					6.72482e-11	7.64132e-11	0.003163	1	0
SLC47A1	55244	broad.mit.edu	37	17	19470431	19470431	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:19470431G>A	uc002gvy.1	+	14	1285	c.1199G>A	c.(1198-1200)AGG>AAG	p.R400K	SLC47A1_uc002gvx.2_Missense_Mutation_p.R400K|SLC47A1_uc010vyz.1_Missense_Mutation_p.R377K|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Missense_Mutation_p.R205K|SLC47A1_uc010vza.1_Missense_Mutation_p.R112K|SLC47A1_uc010vzb.1_Missense_Mutation_p.R134K|SLC47A1_uc010vzc.1_Missense_Mutation_p.R72K	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	400	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GGTGTTCTGAGGGGGAGTGGA	0.527			NA											8	196					0	0	0.004482	0	0
CYTSB	92521	broad.mit.edu	37	17	20108581	20108581	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:20108581G>T	uc002gwq.2	+	4	1364	c.1219G>T	c.(1219-1221)GAA>TAA	p.E407*	CYTSB_uc010cqx.2_Nonsense_Mutation_p.E407*|CYTSB_uc002gwr.2_Nonsense_Mutation_p.E407*|CYTSB_uc002gws.2_Nonsense_Mutation_p.E407*|CYTSB_uc002gwv.2_Nonsense_Mutation_p.E326*|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Nonsense_Mutation_p.E183*|CYTSB_uc002gwt.2_Nonsense_Mutation_p.E326*|CYTSB_uc002gwu.2_Nonsense_Mutation_p.E326*	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	407						nucleus					0						AATGGTACAGGAATTGACAGC	0.418			NA											14	53					0.00244969	0.00252933	0.00245	1	0
CYTSB	92521	broad.mit.edu	37	17	20108588	20108588	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:20108588C>T	uc002gwq.2	+	4	1371	c.1226C>T	c.(1225-1227)ACA>ATA	p.T409I	CYTSB_uc010cqx.2_Missense_Mutation_p.T409I|CYTSB_uc002gwr.2_Missense_Mutation_p.T409I|CYTSB_uc002gws.2_Missense_Mutation_p.T409I|CYTSB_uc002gwv.2_Missense_Mutation_p.T328I|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.T185I|CYTSB_uc002gwt.2_Missense_Mutation_p.T328I|CYTSB_uc002gwu.2_Missense_Mutation_p.T328I	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	409						nucleus					0						CAGGAATTGACAGCTGAAAAT	0.413			NA											14	54					0	0	0.00245	0	0
RHOT1	55288	broad.mit.edu	37	17	30526552	30526552	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:30526552A>G	uc002hgz.2	+	13	1322	c.1083A>G	c.(1081-1083)GGA>GGG	p.G361G	RHOT1_uc002hgw.2_Silent_p.G361G|RHOT1_uc002hgy.2_Silent_p.G361G|RHOT1_uc002hha.2_Silent_p.G234G|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Silent_p.G234G|RHOT1_uc010wby.1_Silent_p.G361G|RHOT1_uc002hhb.2_Silent_p.G340G|RHOT1_uc002hgv.2_Silent_p.G361G	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	361	Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				CCTACCAGGGATTCCTTTCCC	0.378			NA											25	70					0	0	0.007291	0	0
MED1	5469	broad.mit.edu	37	17	37563895	37563895	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:37563895T>C	uc002hrv.3	-	17	4791	c.4579A>G	c.(4579-4581)AGC>GGC	p.S1527G	MED1_uc010wee.1_Missense_Mutation_p.S1355G|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1527	Lys-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GGCTTGATGCTATGAGATTTT	0.318	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			30	70					0	0	0.010818	0	0
TOP2A	7153	broad.mit.edu	37	17	38556186	38556186	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:38556186G>A	uc002huq.2	-	24	3260	c.3134C>T	c.(3133-3135)TCT>TTT	p.S1045F		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1045					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CAGTTTAGCAGATTCAGCACC	0.333			NA											4	31					0	0	0.009096	0	0
BRCA1	672	broad.mit.edu	37	17	41258529	41258529	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:41258529G>T	uc002icq.2	-	4	388	c.156C>A	c.(154-156)CTC>CTA	p.L52L	BRCA1_uc010whp.1_Silent_p.L5L|BRCA1_uc010whl.1_Silent_p.L52L|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_5'UTR|BRCA1_uc002icu.2_Silent_p.L52L|BRCA1_uc010cyx.2_Silent_p.L5L|BRCA1_uc002ict.2_Silent_p.L52L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_5'Flank|BRCA1_uc002idc.1_Silent_p.L52L|BRCA1_uc010whr.1_Silent_p.L5L|BRCA1_uc002idd.2_Silent_p.L52L|BRCA1_uc002ide.1_5'Flank|BRCA1_uc010cyy.1_Silent_p.L52L|BRCA1_uc010whs.1_Silent_p.L52L|BRCA1_uc010cyz.2_Silent_p.L5L|BRCA1_uc010cza.2_Intron|BRCA1_uc010wht.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	52	RING-type.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCTTCTGGTTGAGAAGTTTCA	0.323			NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			5	46					2.0095e-06	2.17587e-06	0.001984	1	0
MPP3	4356	broad.mit.edu	37	17	41891569	41891569	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:41891569C>G	uc002iei.3	-	15	1336	c.1170G>C	c.(1168-1170)CTG>CTC	p.L390L	MPP3_uc002ieh.2_Silent_p.L415L|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	390	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		ACCTACCGATCAGAACCACCA	0.612			NA											40	176					0	0	0.006999	0	0
NFE2L1	4779	broad.mit.edu	37	17	46128846	46128846	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:46128846C>T	uc002imz.3	+	2	1017	c.366C>T	c.(364-366)CTC>CTT	p.L122L	NFE2L1_uc002ina.3_Silent_p.L122L|NFE2L1_uc002inb.3_Silent_p.L122L|NFE2L1_uc002inc.1_Silent_p.L122L	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	122					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						ACTCAGGCCTCGCCCTCGAGA	0.592			NA											6	116					0	0	0.001168	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241632	47241632	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:47241632G>A	uc002ion.2	+	8	1188	c.1129G>A	c.(1129-1131)GGG>AGG	p.G377R	B4GALNT2_uc010wlt.1_Missense_Mutation_p.G291R|B4GALNT2_uc010wlu.1_Missense_Mutation_p.G317R	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	377	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			TATGCCCTTTGGGAAGGTATG	0.532	GBM(124;244 1635 8663 18097 33175)		NA											21	143					0	0	0.014323	0	0
ABCC3	8714	broad.mit.edu	37	17	48736659	48736659	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:48736659G>A	uc002isl.2	+	7	816	c.736G>A	c.(736-738)GAG>AAG	p.E246K	ABCC3_uc002isk.3_Missense_Mutation_p.E246K	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	246	Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTAAAGGAAGAGGACAGATC	0.642			NA											15	107					0	0	0.004007	0	0
ANKFN1	162282	broad.mit.edu	37	17	54534307	54534307	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:54534307G>A	uc002iun.1	+	11	1337	c.1302G>A	c.(1300-1302)GTG>GTA	p.V434V		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	434										large_intestine(1)|ovary(1)	2						ACAAGTTTGTGAAGACCTTAA	0.383			NA											4	48					0	0	0.001168	0	0
AKAP1	8165	broad.mit.edu	37	17	55194219	55194219	+	Splice_Site	SNP	A	A	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:55194219A>C	uc002iux.2	+	8	2664	c.2433_splice	c.e8-2	p.R811_splice	AKAP1_uc010wnl.1_Splice_Site_p.R811_splice|AKAP1_uc010dcm.2_Splice_Site_p.R811_splice	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor						blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					TTGCCTTCCCAGGTCTGACTT	0.517			NA											20	124					0	0	0.010504	0	0
EPX	8288	broad.mit.edu	37	17	56277623	56277623	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:56277623C>T	uc002ivq.2	+	10	1661	c.1575C>T	c.(1573-1575)ACC>ACT	p.T525T		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	525					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TCATGGCCACCCCTGCCAAGC	0.612			NA									OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	55					0	0	0.01441	0	0
INTS2	57508	broad.mit.edu	37	17	59958421	59958421	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:59958421C>T	uc002izn.2	-	17	2301	c.2225G>A	c.(2224-2226)CGA>CAA	p.R742Q	INTS2_uc002izm.2_Missense_Mutation_p.R734Q	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	742					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						CAGGAGCATTCGCCGTAGCAG	0.398			NA											15	87					0	0	0.003163	0	0
ABCA6	23460	broad.mit.edu	37	17	67129836	67129836	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:67129836C>G	uc002jhw.1	-	6	912	c.737G>C	c.(736-738)AGA>ACA	p.R246T		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	246					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AGACTTTTTTCTCTCTTTTGT	0.294			NA											7	76					0	0	0.00308	0	0
CD300E	342510	broad.mit.edu	37	17	72613371	72613371	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:72613371G>T	uc002jlb.1	-	2	315	c.274C>A	c.(274-276)CAG>AAG	p.Q92K		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	92	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TTGAGGTTCTGCATGGTCACA	0.542			NA											21	150					5.35356e-11	6.10397e-11	0.00278	1	0
SEPT9	10801	broad.mit.edu	37	17	75478401	75478401	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:75478401C>G	uc002jts.3	+	4	1023	c.897C>G	c.(895-897)TTC>TTG	p.F299L	SEPT9_uc010wtk.1_Missense_Mutation_p.F280L|SEPT9_uc002jtt.3_Missense_Mutation_p.F135L|SEPT9_uc002jtu.3_Missense_Mutation_p.F281L|SEPT9_uc002jtv.2_Missense_Mutation_p.F292L|SEPT9_uc002jtw.2_Missense_Mutation_p.F135L|SEPT9_uc002jtx.1_Missense_Mutation_p.F135L|SEPT9_uc010wtl.1_Missense_Mutation_p.F75L|SEPT9_uc002jty.3_Missense_Mutation_p.F48L|SEPT9_uc010wtm.1_Missense_Mutation_p.F48L|SEPT9_uc010wtn.1_Missense_Mutation_p.F48L|SEPT9_uc010dhd.2_Missense_Mutation_p.F187L	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	299					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			GCTTCGAGTTCAACATCATGG	0.612			NA											5	48					0	0	0.001168	0	0
ENGASE	64772	broad.mit.edu	37	17	77082418	77082418	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:77082418C>G	uc002jwv.2	+	14	2227	c.2219C>G	c.(2218-2220)TCA>TGA	p.S740*	ENGASE_uc002jww.2_Nonsense_Mutation_p.S445*	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	740						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						CTGCTTTATTCAGCCCCTGCA	0.652			NA											7	59					0	0	0.001984	0	0
ACTG1	71	broad.mit.edu	37	17	79478006	79478006	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:79478006C>T	uc002kaj.1	-	4	956	c.931G>A	c.(931-933)GAC>AAC	p.D311N	ACTG1_uc002kah.1_Missense_Mutation_p.D189N|ACTG1_uc002kai.1_Missense_Mutation_p.D268N|ACTG1_uc002kak.1_Missense_Mutation_p.D311N|ACTG1_uc010wun.1_Missense_Mutation_p.D311N|ACTG1_uc002kal.1_Missense_Mutation_p.D311N|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	311					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TGCATCCTGTCGGCAATGCCC	0.612			NA											15	85					0	0	0.003163	0	0
LAMA1	284217	broad.mit.edu	37	18	7044805	7044805	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:7044805C>A	uc002knm.2	-	7	986	c.892G>T	c.(892-894)GGG>TGG	p.G298W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	298	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCTCTCCCCGCAAGTATTA	0.448			NA											43	106					9.58827e-17	1.14e-16	0.01441	1	0
PPP4R1	9989	broad.mit.edu	37	18	9570248	9570248	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:9570248G>A	uc002koe.1	-	11	1598	c.1480C>T	c.(1480-1482)CCC>TCC	p.P494S	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Missense_Mutation_p.P340S|PPP4R1_uc002kod.1_Missense_Mutation_p.P477S|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	494					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						GGAGAACTGGGCACAGGGCCC	0.478	Melanoma(188;1232 2082 5061 11948 35994)		NA											25	41					0	0	0.00278	0	0
TXNDC2	84203	broad.mit.edu	37	18	9888081	9888081	+	Silent	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:9888081T>C	uc002koi.3	+	2	2054	c.1605T>C	c.(1603-1605)GAT>GAC	p.D535D	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Silent_p.D468D	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	535	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AAAAGGTGGATGAACTTTGCG	0.433			NA											11	27					0	0	0.001855	0	0
CABYR	26256	broad.mit.edu	37	18	21735667	21735667	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:21735667G>A	uc002kux.2	+	4	354	c.202G>A	c.(202-204)GAG>AAG	p.E68K	CABYR_uc010xbb.1_5'UTR|CABYR_uc002kuy.2_Missense_Mutation_p.E68K|CABYR_uc002kuz.2_Missense_Mutation_p.E68K|CABYR_uc002kva.2_Missense_Mutation_p.E50K|CABYR_uc002kvb.2_5'UTR|CABYR_uc002kvc.2_Missense_Mutation_p.E68K|CABYR_uc010dlw.2_RNA	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	68					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					TTTTTCAGTAGAGAAATGGTC	0.294			NA											12	35					0	0	0.013537	0	0
NOL4	8715	broad.mit.edu	37	18	31599332	31599332	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:31599332G>A	uc010dmi.2	-	6	1235	c.1006C>T	c.(1006-1008)CTA>TTA	p.L336L	NOL4_uc010xbs.1_Silent_p.L51L|NOL4_uc002kxr.3_Silent_p.L172L|NOL4_uc010xbt.1_Silent_p.L262L|NOL4_uc010dmh.2_Silent_p.L262L|NOL4_uc010xbu.1_Silent_p.L336L|NOL4_uc002kxt.3_Silent_p.L336L|NOL4_uc010xbv.1_Silent_p.L85L|NOL4_uc010xbw.1_Silent_p.L222L	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	336						nucleolus	RNA binding			ovary(3)	3						TCAGAAATTAGAAGATTCTTA	0.413			NA											13	33					0	0	0.00245	0	0
FHOD3	80206	broad.mit.edu	37	18	34273246	34273246	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:34273246G>C	uc002kzt.1	+	13	1617	c.1520G>C	c.(1519-1521)AGA>ACA	p.R507T	FHOD3_uc002kzr.1_Missense_Mutation_p.R507T|FHOD3_uc002kzs.1_Missense_Mutation_p.R524T|FHOD3_uc010dmz.1_Missense_Mutation_p.R239T|FHOD3_uc010dna.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	507					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AGCCGGGGCAGAGCCGACCTC	0.567			NA											4	23					0	0	0.000602	0	0
NETO1	81832	broad.mit.edu	37	18	70451117	70451117	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr18:70451117C>T	uc002lkw.2	-	7	948	c.664G>A	c.(664-666)GAG>AAG	p.E222K	NETO1_uc002lkx.1_Missense_Mutation_p.E221K|NETO1_uc002lky.1_Missense_Mutation_p.E222K	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	222	CUB 2.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TTCTGCATCTCATAGTCCAAG	0.348			NA											23	79					0	0	0.012319	0	0
SPPL2B	56928	broad.mit.edu	37	19	2337592	2337592	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:2337592C>T	uc002lvs.2	+	3	417	c.337C>T	c.(337-339)CGC>TGC	p.R113C	SPPL2B_uc010dsw.1_Missense_Mutation_p.R85C|SPPL2B_uc010dsy.1_Missense_Mutation_p.R85C|SPPL2B_uc010dsz.1_Missense_Mutation_p.R113C|SPPL2B_uc002lvr.2_Missense_Mutation_p.R113C|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	113	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCGGAGCACGCGGGCTGCT	0.692			NA											7	16					0	0	0.001984	0	0
SPPL2B	56928	broad.mit.edu	37	19	2337594	2337594	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:2337594C>G	uc002lvs.2	+	3	419	c.339C>G	c.(337-339)CGC>CGG	p.R113R	SPPL2B_uc010dsw.1_Silent_p.R85R|SPPL2B_uc010dsy.1_Silent_p.R85R|SPPL2B_uc010dsz.1_Silent_p.R113R|SPPL2B_uc002lvr.2_Silent_p.R113R|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	113	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGAGCACGCGGGCTGCTCA	0.692			NA											7	15					0	0	0.001984	0	0
STAP2	55620	broad.mit.edu	37	19	4325283	4325283	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:4325283G>A	uc002mab.2	-	11	1099	c.1002C>T	c.(1000-1002)GTC>GTT	p.V334V	STAP2_uc002mac.2_Silent_p.V334V|STAP2_uc002mad.2_Silent_p.V227V	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	334	Pro-rich.					cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCAGGATGACTGGCCAAC	0.562			NA											8	8					0	0	0.00308	0	0
PLIN5	440503	broad.mit.edu	37	19	4523664	4523664	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:4523664T>G	uc002mas.2	-	8	1321	c.1268A>C	c.(1267-1269)CAC>CCC	p.H423P		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	423						lipid particle					0						CCCGTCCCTGTGCTCTGCCTC	0.706			NA									OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	105					0	0	0.006999	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964676	7964676	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:7964676C>G	uc002mir.2	+	3	1370	c.1269C>G	c.(1267-1269)CTC>CTG	p.L423L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	423						integral to membrane				lung(1)|pancreas(1)	2						AGCTGGCCCTCTGCATGCTGC	0.627			NA											5	32					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9058315	9058315	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:9058315C>T	uc002mkp.2	-	3	29335	c.29131G>A	c.(29131-29133)GAA>AAA	p.E9711K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9713	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACAGACTTTCAGGACCCCTG	0.488			NA											7	26					0	0	0.00308	0	0
MUC16	94025	broad.mit.edu	37	19	9064992	9064992	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:9064992G>T	uc002mkp.2	-	3	22658	c.22454C>A	c.(22453-22455)TCC>TAC	p.S7485Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7487	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCAGAACTGGAAGTTCCAAC	0.478			NA											23	52					7.87624e-14	9.21659e-14	0.00278	1	0
OR7D4	125958	broad.mit.edu	37	19	9324997	9324997	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:9324997C>T	uc002mla.1	-	1	517	c.517G>A	c.(517-519)GAG>AAG	p.E173K		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E173K(1)		ovary(2)|central_nervous_system(1)|skin(1)	4						TGCGGAATCTCAGTGCCTGTG	0.507			NA											15	58					0	0	0.003163	0	0
ZNF562	54811	broad.mit.edu	37	19	9763741	9763741	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:9763741G>C	uc010xks.1	-	6	1328	c.1165C>G	c.(1165-1167)CAA>GAA	p.Q389E	ZNF562_uc002mly.2_Missense_Mutation_p.Q389E|ZNF562_uc002mlx.2_Missense_Mutation_p.Q317E|ZNF562_uc010xkt.1_Missense_Mutation_p.Q352E|ZNF562_uc010xku.1_Missense_Mutation_p.Q320E|ZNF562_uc010xkv.1_Missense_Mutation_p.Q388E|ZNF562_uc010xkw.1_Missense_Mutation_p.Q273E	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	389	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTATGTTGAGTAAGCGTT	0.408			NA											13	45					0	0	0.013537	0	0
ZNF846	162993	broad.mit.edu	37	19	9872820	9872820	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:9872820C>A	uc002mmb.1	-	4	698	c.167G>T	c.(166-168)AGT>ATT	p.S56I	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_5'UTR	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	56	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGACATGAGACTACGTTTGAA	0.458			NA											22	78					6.44725e-10	7.2518e-10	0.014323	1	0
ICAM5	7087	broad.mit.edu	37	19	10406060	10406060	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:10406060G>A	uc002mnu.3	+	10	2334	c.2269G>A	c.(2269-2271)GGA>AGA	p.G757R	ICAM5_uc002mnv.3_Missense_Mutation_p.G632R	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	757	Extracellular (Potential).|Ig-like C2-type 9.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CTCGCCCCCTGGAGGCGTGCG	0.582			NA											5	18					0	0	0.001168	0	0
ICAM5	7087	broad.mit.edu	37	19	10406079	10406079	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:10406079G>A	uc002mnu.3	+	10	2353	c.2288G>A	c.(2287-2289)GGA>GAA	p.G763E	ICAM5_uc002mnv.3_Missense_Mutation_p.G638E	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	763	Extracellular (Potential).|Ig-like C2-type 9.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCCCAGGAGGAAACTTCACG	0.592			NA											4	15					0	0	0.009096	0	0
PDE4A	5141	broad.mit.edu	37	19	10570163	10570163	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:10570163A>G	uc002moj.2	+	9	1297	c.1189A>G	c.(1189-1191)ATG>GTG	p.M397V	PDE4A_uc002mok.2_Missense_Mutation_p.M371V|PDE4A_uc002mol.2_Missense_Mutation_p.M336V|PDE4A_uc002mom.2_Missense_Mutation_p.M158V|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_Missense_Mutation_p.M63V	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	397	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CATCATGTACATGATATTCCA	0.622			NA											6	20					0	0	0.001984	0	0
CNN1	1264	broad.mit.edu	37	19	11657493	11657493	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:11657493C>T	uc002msc.1	+	3	353	c.189C>T	c.(187-189)TTC>TTT	p.F63F	CNN1_uc010xmb.1_Silent_p.F13F|CNN1_uc010xmc.1_Silent_p.F13F	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	63	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						TTCTCAGATTCATCAATAAGC	0.378			NA											14	52					0	0	0.003163	0	0
ZNF709	163051	broad.mit.edu	37	19	12575365	12575365	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:12575365G>A	uc002mtv.3	-	4	1532	c.1371C>T	c.(1369-1371)TTC>TTT	p.F457F	ZNF709_uc002mtw.3_Silent_p.F425F|ZNF709_uc002mtx.3_Silent_p.F457F	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	457	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGGAACAACTGAAGGCTTTAC	0.398	GBM(33;565 669 12371 29134 51667)		NA											25	86					0	0	0.007291	0	0
ZNF709	163051	broad.mit.edu	37	19	12575934	12575934	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:12575934G>A	uc002mtv.3	-	4	963	c.802C>T	c.(802-804)CAA>TAA	p.Q268*	ZNF709_uc002mtw.3_Nonsense_Mutation_p.Q236*|ZNF709_uc002mtx.3_Nonsense_Mutation_p.Q268*	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	268	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATGTATTTGAAAAGTTTGG	0.383	GBM(33;565 669 12371 29134 51667)		NA											9	27					0	0	0.004482	0	0
IER2	9592	broad.mit.edu	37	19	13264100	13264100	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:13264100C>T	uc002mwr.2	+	2	428	c.100C>T	c.(100-102)CTG>TTG	p.L34L		NM_004907	NP_004898	Q9BTL4	IER2_HUMAN	immediate early response 2	34										kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			GCACCGGAGTCTGCAGCTGTC	0.667			NA									OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					0	0	0.001168	0	0
CLEC17A	388512	broad.mit.edu	37	19	14707757	14707757	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:14707757A>G	uc010dzn.1	+	9	592	c.515A>G	c.(514-516)TAC>TGC	p.Y172C	CLEC17A_uc002mzh.1_Missense_Mutation_p.Y155C|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Missense_Mutation_p.Y172C|CLEC17A_uc010dzo.1_Missense_Mutation_p.Y172C			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	172	Cytoplasmic (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						TGGATGGTGTACCTGTGTCTG	0.587			NA											4	10					0	0	0.009096	0	0
EMR2	30817	broad.mit.edu	37	19	14876338	14876338	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:14876338G>A	uc002mzp.1	-	9	1282	c.826C>T	c.(826-828)CAG>TAG	p.Q276*	EMR2_uc010dzs.1_5'UTR|EMR2_uc010xnw.1_Nonsense_Mutation_p.Q276*|EMR2_uc002mzo.1_Nonsense_Mutation_p.Q276*|EMR2_uc002mzq.1_Nonsense_Mutation_p.Q227*|EMR2_uc002mzr.1_Nonsense_Mutation_p.Q227*|EMR2_uc002mzs.1_Nonsense_Mutation_p.Q134*|EMR2_uc002mzt.1_Nonsense_Mutation_p.Q183*|EMR2_uc002mzu.1_Nonsense_Mutation_p.Q183*|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	276	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						CCACTCACCTGGCTGTGGACT	0.612			NA											4	22					0	0	0.001168	0	0
OR7C2	26658	broad.mit.edu	37	19	15052879	15052879	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:15052879C>A	uc010xoc.1	+	1	579	c.579C>A	c.(577-579)TTC>TTA	p.F193L		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					CTGACACCTTCATCAATAACA	0.428			NA											21	53					2.4624e-09	2.75574e-09	0.008871	1	0
LOC284441	284441	broad.mit.edu	37	19	20369855	20369855	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:20369855C>G	uc002nov.2	+	1	1399	c.648C>G	c.(646-648)ATC>ATG	p.I216M		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						CTCACTTGATCAATGTTGAAG	0.398			NA											7	19					0	0	0.001984	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727915	20727915	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:20727915C>T	uc002npa.2	-	4	1274	c.1094G>A	c.(1093-1095)GGA>GAA	p.G365E		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	365					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGGTTTCTCTCCACTATGAAT	0.393			NA											11	35					0	0	0.010729	0	0
ZFP30	22835	broad.mit.edu	37	19	38135626	38135626	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:38135626C>T	uc002ogv.1	-	4	537	c.21G>A	c.(19-21)ATG>ATA	p.M7I	ZFP30_uc002ogw.1_Missense_Mutation_p.M7I|ZFP30_uc002ogx.1_Missense_Mutation_p.M7I|ZFP30_uc010xtt.1_Missense_Mutation_p.M7I	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATCTCTGAACATCACCAAAT	0.303			NA											10	41					0	0	0.010729	0	0
RYR1	6261	broad.mit.edu	37	19	39001185	39001185	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:39001185G>C	uc002oit.2	+	59	9110	c.8980G>C	c.(8980-8982)GAG>CAG	p.E2994Q	RYR1_uc002oiu.2_Missense_Mutation_p.E2994Q|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2994	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACATGAACAGGAGATTAAATT	0.567			NA											21	73					0	0	0.010504	0	0
PSG2	5670	broad.mit.edu	37	19	43579684	43579684	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:43579684G>T	uc002ovr.2	-	3	624	c.531C>A	c.(529-531)AGC>AGA	p.S177R	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.S177R|PSG2_uc010eiq.1_Missense_Mutation_p.S177R|PSG2_uc002ovs.3_Missense_Mutation_p.S177R|PSG2_uc002ovt.3_Missense_Mutation_p.S177R	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	177	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				ACCACTGGTAGCTTGTGTCCG	0.502			NA											59	224					7.41606e-26	9.1772e-26	0.01441	1	0
ZNF223	7766	broad.mit.edu	37	19	44570525	44570526	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:44570525_44570526GG>TT	uc002oyf.1	+	5	797_798	c.544_545GG>TT	c.(544-546)GGA>TTA	p.G182L	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	182	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TGATGAGTGTGGAAAAAGCTTC	0.431			NA											44	117					0	0	0.004672	0	0
ZFP112	7771	broad.mit.edu	37	19	44833574	44833574	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:44833574G>A	uc010ejj.2	-	5	867	c.754C>T	c.(754-756)CAA>TAA	p.Q252*	ZFP112_uc002ozc.3_Nonsense_Mutation_p.Q246*|ZFP112_uc010xwy.1_Nonsense_Mutation_p.Q269*|ZFP112_uc010xwz.1_Nonsense_Mutation_p.Q251*	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TCCTCTGTTTGAATTGACTCC	0.423	Melanoma(53;975 1202 7512 15993 27273)		NA											19	63					0	0	0.007413	0	0
CLPTM1	1209	broad.mit.edu	37	19	45493695	45493695	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:45493695C>G	uc002pai.2	+	10	1190	c.1175C>G	c.(1174-1176)TCC>TGC	p.S392C	CLPTM1_uc010xxf.1_Missense_Mutation_p.S290C|CLPTM1_uc010xxg.1_Missense_Mutation_p.S378C	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	392	Helical; (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GAGGGCCTGTCCGTGCGCTCC	0.597			NA											38	157					0	0	0.007835	0	0
CD3EAP	10849	broad.mit.edu	37	19	45912504	45912504	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:45912504G>C	uc002pbq.1	+	3	1766	c.1278G>C	c.(1276-1278)AAG>AAC	p.K426N	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Missense_Mutation_p.K428N	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	426	Poly-Lys.				rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		agaagaagaagaagaaagaga	0.537			NA											13	27					0	0	0.013537	0	0
EML2	24139	broad.mit.edu	37	19	46124873	46124873	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:46124873C>T	uc002pcn.2	-	10	899	c.864G>A	c.(862-864)GCG>GCA	p.A288A	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Silent_p.A172A|EML2_uc010xxl.1_Silent_p.A435A|EML2_uc010xxm.1_Silent_p.A489A|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Silent_p.A288A|EML2_uc010ekj.2_Missense_Mutation_p.R255Q	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	288	WD 4.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		CGCCCAGCACCGCCTGTGTGA	0.672			NA											4	29					0	0	0.001168	0	0
PIH1D1	55011	broad.mit.edu	37	19	49950617	49950617	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:49950617C>T	uc002pns.2	-	6	873	c.589G>A	c.(589-591)GCC>ACC	p.A197T		NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	197					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		CTCCCGGGGGCGGGCGTGTAC	0.627			NA											14	59					0	0	0.004007	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50453287	50453287	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:50453287C>T	uc010ybh.1	-	11	2128	c.2037G>A	c.(2035-2037)CTG>CTA	p.L679L	SIGLEC11_uc010ybi.1_Silent_p.L583L	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	679	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CTGGGCCCCTCAGGGGCTGTC	0.612			NA											6	19					0	0	0.001168	0	0
ZNF610	162963	broad.mit.edu	37	19	52869486	52869486	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:52869486G>T	uc002pyx.3	+	6	1261	c.855G>T	c.(853-855)GAG>GAT	p.E285D	ZNF610_uc002pyy.3_Missense_Mutation_p.E285D|ZNF610_uc002pyz.3_Missense_Mutation_p.E242D|ZNF610_uc002pza.2_Missense_Mutation_p.E285D	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		ATACTGGAGAGAAGCCTCACA	0.393			NA											11	35					2.80697e-09	3.13086e-09	0.010729	1	0
KIR3DX1	90011	broad.mit.edu	37	19	55049204	55049204	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:55049204C>T	uc010erm.2	+	2	282	c.270C>T	c.(268-270)CTC>CTT	p.L90L	KIR3DX1_uc010yfa.1_RNA|KIR3DX1_uc010yfb.1_RNA|KIR3DX1_uc010yfc.1_RNA|KIR3DX1_uc010yfd.1_RNA					Homo sapiens killer cell immunoglobulin-like receptor, three domains, X1, mRNA (cDNA clone IMAGE:4849085).											ovary(1)	1				GBM - Glioblastoma multiforme(193;0.099)		GAGTACTCCTCTGTCATTCAC	0.343	Colon(183;529 2002 28270 32358 35845)|Esophageal Squamous(50;443 1006 2278 10294 37938)		NA											24	81					0	0	0.005443	0	0
KIR2DS4	3809	broad.mit.edu	37	19	55349312	55349312	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:55349312C>A	uc002qhm.1	+	3	398	c.352C>A	c.(352-354)CTG>ATG	p.L118M	KIR2DS4_uc010yfj.1_Missense_Mutation_p.L111M|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.L118M|KIR2DS4_uc002qhn.1_Missense_Mutation_p.L65M	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	118	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CAGTGACCCTCTGGACATGGT	0.507			NA											74	285					1.13027e-35	1.42782e-35	0.01441	1	0
PEG3	5178	broad.mit.edu	37	19	57334186	57334186	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:57334186C>A	uc002qnu.2	-	3	851	c.500G>T	c.(499-501)CGG>CTG	p.R167L	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.R42L|ZIM2_uc002qnq.2_Missense_Mutation_p.R42L|ZIM2_uc010etp.2_Missense_Mutation_p.R42L|ZIM2_uc010ygs.1_Missense_Mutation_p.R42L|PEG3_uc002qnt.2_Missense_Mutation_p.R168L|PEG3_uc002qnv.2_Missense_Mutation_p.R167L|PEG3_uc002qnw.2_Missense_Mutation_p.R42L|PEG3_uc002qnx.2_Missense_Mutation_p.R41L|PEG3_uc010etr.2_Missense_Mutation_p.R167L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	167					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCTGCCCCTCCGGTCCCAGTC	0.542			NA											7	10					8.12818e-05	8.59192e-05	0.001984	1	0
ZNF547	284306	broad.mit.edu	37	19	57888907	57888907	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:57888907A>G	uc002qol.2	+	4	756	c.563A>G	c.(562-564)AAA>AGA	p.K188R	ZNF547_uc002qpm.3_Missense_Mutation_p.K114R|ZNF547_uc010ygx.1_Missense_Mutation_p.K188R	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	188	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGTGCAGCAAATGTGGGATA	0.413			NA											22	58					0	0	0.00333	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58563859	58563859	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:58563859C>T	uc002qrc.1	+	5	714	c.467C>T	c.(466-468)GCG>GTG	p.A156V		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	156					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCATTCTAGGCGTCTGAGCTG	0.617			NA											15	56					0	0	0.006122	0	0
RNASEH1	246243	broad.mit.edu	37	2	3605786	3605786	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:3605786G>C	uc002qxt.2	-	1	155	c.65C>G	c.(64-66)TCT>TGT	p.S22C	RNASEH1_uc002qxs.2_5'UTR|uc002qxu.2_5'Flank|uc002qxv.2_5'Flank	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	22					RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		GAACCCGCGAGAGCCGCGGCG	0.697			NA											2	8					0	0	0.004672	0	0
NT5C1B	93034	broad.mit.edu	37	2	18736478	18736478	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:18736478C>T	uc010exr.2	-	9	2036	c.1932G>A	c.(1930-1932)GTG>GTA	p.V644V	NT5C1B_uc002rcy.2_3'UTR|RDH14_uc002rcx.3_Silent_p.V330V	NM_033253	NP_150278	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 2	Error:Variant_position_missing_in_Q96P26_after_alignment					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGCCAACCATCACTTCACTGA	0.398			NA											19	104					0	0	0.010504	0	0
APOB	338	broad.mit.edu	37	2	21225915	21225915	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:21225915C>T	uc002red.2	-	29	12507	c.12379G>A	c.(12379-12381)GAC>AAC	p.D4127N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4127					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACCTCACGTCGATATCATCA	0.502			NA											12	135					0	0	0.001855	0	0
OTOF	9381	broad.mit.edu	37	2	26750699	26750699	+	Splice_Site	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:26750699C>A	uc002rhk.2	-	3	354	c.227_splice	c.e3+1	p.K76_splice		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a						cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCACACTTACTTGTTGCTGA	0.562	GBM(102;732 1451 20652 24062 31372)		NA											8	69					0.000442599	0.000463444	0.006214	1	0
LRPPRC	10128	broad.mit.edu	37	2	44204152	44204152	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:44204152C>T	uc002rtr.2	-	5	689	c.631G>A	c.(631-633)GGA>AGA	p.G211R	LRPPRC_uc010yob.1_Missense_Mutation_p.G111R|LRPPRC_uc010faw.1_Missense_Mutation_p.G185R	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	211	PPR 3.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCAATATCTCCTACATTACAA	0.303			NA											3	40					0	0	0.004672	0	0
PPM1B	5495	broad.mit.edu	37	2	44428516	44428516	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:44428516G>C	uc002rtt.2	+	2	606	c.178G>C	c.(178-180)GAT>CAT	p.D60H	PPM1B_uc002rts.2_Missense_Mutation_p.D60H|PPM1B_uc002rtu.2_Missense_Mutation_p.D60H|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.D60H|PPM1B_uc002rtx.2_Missense_Mutation_p.D60H	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	60		Manganese 1 (By similarity).|Manganese 2 (By similarity).			protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGCAGTTTATGATGGTCATGC	0.448			NA											37	144					0	0	0.004878	0	0
MCFD2	90411	broad.mit.edu	37	2	47136169	47136169	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:47136169C>G	uc002rvk.2	-	2	236	c.142G>C	c.(142-144)GAC>CAC	p.D48H	MCFD2_uc002rvl.2_Intron|MCFD2_uc010fba.2_Missense_Mutation_p.D46H|MCFD2_uc010yof.1_Intron	NM_139279	NP_644808	Q8NI22	MCFD2_HUMAN	multiple coagulation factor deficiency 2	48					post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|vesicle-mediated transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	calcium ion binding			central_nervous_system(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Antihemophilic Factor(DB00025)	TACTCTTGGTCGTGCACTGTG	0.622			NA											16	78					0	0	0.008871	0	0
FSHR	2492	broad.mit.edu	37	2	49190117	49190117	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:49190117G>A	uc002rww.2	-	10	1917	c.1843C>T	c.(1843-1845)CAC>TAC	p.H615Y	FSHR_uc002rwx.2_Missense_Mutation_p.H553Y|FSHR_uc010fbn.2_Missense_Mutation_p.H589Y	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	615	Helical; Name=7; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TTGATGGGGTGAAACAGAACC	0.483			NA							Gonadal_Dysgenesis_46_XX				8	59					0	0	0.006214	0	0
NRXN1	9378	broad.mit.edu	37	2	50574003	50574003	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:50574003C>A	uc010fbp.2	-	1	892	c.85G>T	c.(85-87)GGG>TGG	p.G29W	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	29					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCCAGGCGCCCCCCTGcgccg	0.582			NA											5	6					1.23904e-05	1.32442e-05	0.000602	1	0
C2orf73	129852	broad.mit.edu	37	2	54587462	54587462	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:54587462G>C	uc002rxt.1	+	5	669	c.627G>C	c.(625-627)GAG>GAC	p.E209D	C2orf73_uc010yor.1_Missense_Mutation_p.E151D|C2orf73_uc002rxs.1_Missense_Mutation_p.E88D|C2orf73_uc010yos.1_RNA	NM_001100396	NP_001093866	Q8N5S3	CB073_HUMAN	hypothetical protein LOC129852	209											0						AAAAAACAGAGAAAGGAAACT	0.448			NA											3	24					0	0	0.004672	0	0
USP34	9736	broad.mit.edu	37	2	61522325	61522325	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:61522325C>G	uc002sbe.2	-	31	4377	c.4355G>C	c.(4354-4356)AGA>ACA	p.R1452T		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1452					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCTTATTCTTCTATTAGGTTT	0.333			NA											24	91					0	0	0.005443	0	0
VAX2	25806	broad.mit.edu	37	2	71160154	71160154	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:71160154G>A	uc002shh.2	+	3	725	c.693G>A	c.(691-693)CCG>CCA	p.P231P	ATP6V1B1_uc002shi.1_5'Flank|ATP6V1B1_uc002shj.2_5'Flank|ATP6V1B1_uc010fdv.2_5'Flank|ATP6V1B1_uc010fdw.2_5'Flank	NM_012476	NP_036608	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	231					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCTCAACCCGCTGTCCTCGG	0.692			NA											16	41					0	0	0.008871	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518384	84518384	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:84518384G>C	uc010ffz.1	+	1	579	c.442G>C	c.(442-444)GGC>CGC	p.G148R		NR_003663				RecName: Full=FUN14 domain-containing protein 2; AltName: Full=Hepatitis C virus core-binding protein 6; AltName: Full=Cervical cancer proto-oncogene 3 protein;          Short=HCC-3;												0						CTTTCTGCTTGGCATGGCATC	0.468			NA											45	102					0	0	0.01441	0	0
RNF103	7844	broad.mit.edu	37	2	86849937	86849937	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:86849937T>C	uc002srn.2	-	1	1042	c.73A>G	c.(73-75)ATT>GTT	p.I25V	VPS24_uc010ytl.1_Intron|RNF103_uc002srp.2_Missense_Mutation_p.I25V	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	25	Helical; (Potential).				central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						TACCACACAATGGCCTCAAAA	0.522			NA											10	34					0	0	0.006214	0	0
RANBP2	5903	broad.mit.edu	37	2	109382771	109382771	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:109382771G>T	uc002tem.3	+	20	5902	c.5776G>T	c.(5776-5778)GAT>TAT	p.D1926Y		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1926					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CCAGGCTCAGGATATTAGTGG	0.408			NA											96	203					2.57667e-78	3.2736e-78	0.01441	1	0
POLR1B	84172	broad.mit.edu	37	2	113331367	113331367	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:113331367G>T	uc002thw.2	+	14	3080	c.2500G>T	c.(2500-2502)GGG>TGG	p.G834W	POLR1B_uc010fkn.2_Missense_Mutation_p.G778W|POLR1B_uc002thx.2_Missense_Mutation_p.G695W|POLR1B_uc010fko.2_Missense_Mutation_p.G651W|POLR1B_uc010fkp.2_Missense_Mutation_p.G273W|POLR1B_uc010yxn.1_Missense_Mutation_p.G872W|POLR1B_uc002thy.2_Missense_Mutation_p.G695W|POLR1B_uc010yxo.1_Missense_Mutation_p.G611W	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	834					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						CCTCAACACCGGGGAAAGTTT	0.338	Ovarian(16;256 576 9537 23969 41147)		NA											40	93					1.62957e-23	2.0091e-23	0.00874	1	0
WDR33	55339	broad.mit.edu	37	2	128467308	128467308	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:128467308C>A	uc002tpg.1	-	19	3614	c.3431G>T	c.(3430-3432)CGA>CTA	p.R1144L		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1144					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		ATCTCGTCCTCGGGCCGCTTC	0.562			NA											7	161					2.0095e-06	2.17587e-06	0.001984	1	0
SMPD4	55627	broad.mit.edu	37	2	130930378	130930378	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:130930378C>A	uc002tqq.1	-	6	1073	c.553G>T	c.(553-555)GGT>TGT	p.G185C	SMPD4_uc002tqp.1_5'UTR|SMPD4_uc010yzy.1_Intron|SMPD4_uc010yzz.1_Intron|SMPD4_uc002tqr.1_Missense_Mutation_p.G185C|SMPD4_uc002tqs.1_Missense_Mutation_p.G53C|SMPD4_uc002tqt.1_Missense_Mutation_p.G63C|SMPD4_uc010zaa.1_Missense_Mutation_p.G72C|SMPD4_uc010zab.1_Missense_Mutation_p.G112C|SMPD4_uc010zac.1_Intron|SMPD4_uc010zad.1_Intron	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	146					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	AAGTTCAGACCAAGGCCCCCA	0.607			NA											27	30					6.36457e-07	6.93655e-07	0.003954	1	0
NEB	4703	broad.mit.edu	37	2	152500536	152500536	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:152500536C>T	uc010fnx.2	-	57	7943	c.7752G>A	c.(7750-7752)CAG>CAA	p.Q2584Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2584	Nebulin 69.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCCTGTCACTCTGGATCTTGG	0.542			NA											140	292					0	0	0.01441	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711819	155711819	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:155711819C>T	uc002tyv.1	+	3	1695	c.1500C>T	c.(1498-1500)TTC>TTT	p.F500F	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	500	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CTGATCGCTTCACATAACAAA	0.398			NA											7	17					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179424766	179424766	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179424766C>A	uc010zfg.1	-	275	78613	c.78389G>T	c.(78388-78390)TGG>TTG	p.W26130L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W19825L|TTN_uc010zfi.1_Missense_Mutation_p.W19758L|TTN_uc010zfj.1_Missense_Mutation_p.W19633L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27057							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAAGTTTTCCAGTCAGTGTC	0.398			NA											13	37					1.49906e-05	1.5998e-05	0.00245	1	0
TTN	7273	broad.mit.edu	37	2	179433143	179433143	+	Missense_Mutation	SNP	C	C	T	rs56341835		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179433143C>T	uc010zfg.1	-	275	70236	c.70012G>A	c.(70012-70014)GAA>AAA	p.E23338K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17033K|TTN_uc010zfi.1_Missense_Mutation_p.E16966K|TTN_uc010zfj.1_Missense_Mutation_p.E16841K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24265							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAATACTTTCAGCACTGACG	0.408			NA											4	21					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179456184	179456184	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179456184C>A	uc010zfg.1	-	253	52788	c.52564G>T	c.(52564-52566)GTA>TTA	p.V17522L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V11217L|TTN_uc010zfi.1_Missense_Mutation_p.V11150L|TTN_uc010zfj.1_Missense_Mutation_p.V11025L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18449							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGCCTTTACCACAAGACCT	0.393			NA											81	174					7.3878e-23	9.02502e-23	0.01441	1	0
TTN	7273	broad.mit.edu	37	2	179464429	179464429	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179464429G>C	uc010zfg.1	-	238	48719	c.48495C>G	c.(48493-48495)CTC>CTG	p.L16165L	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L9860L|TTN_uc010zfi.1_Silent_p.L9793L|TTN_uc010zfj.1_Silent_p.L9668L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17092							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTGTCATAGAGAACAGGTT	0.438			NA											27	112					0	0	0.00632	0	0
CCDC141	285025	broad.mit.edu	37	2	179718180	179718180	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179718180G>C	uc002unf.1	-	10	1564	c.1507C>G	c.(1507-1509)CAG>GAG	p.Q503E		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	503							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TATAAGTGCTGAGCAAGGTCA	0.433			NA											23	151					0	0	0.005443	0	0
CCDC141	285025	broad.mit.edu	37	2	179718348	179718348	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:179718348G>C	uc002unf.1	-	10	1396	c.1339C>G	c.(1339-1341)CAT>GAT	p.H447D		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	447							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TACCAAAAATGACACTAAATT	0.358			NA											17	55					0	0	0.006122	0	0
NCKAP1	10787	broad.mit.edu	37	2	183791550	183791550	+	Silent	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:183791550T>C	uc002upc.2	-	30	3666	c.3264A>G	c.(3262-3264)CTA>CTG	p.L1088L	NCKAP1_uc002upb.2_Silent_p.L1094L	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	1088					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTACCATATCTAGCAGTAAAT	0.318			NA											20	38					0	0	0.010504	0	0
NCKAP1	10787	broad.mit.edu	37	2	183791552	183791552	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:183791552G>A	uc002upc.2	-	30	3664	c.3262C>T	c.(3262-3264)CTA>TTA	p.L1088L	NCKAP1_uc002upb.2_Silent_p.L1094L	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	1088					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			ACCATATCTAGCAGTAAATAA	0.318			NA											20	37					0	0	0.010504	0	0
ANKAR	150709	broad.mit.edu	37	2	190611111	190611111	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:190611111G>A	uc002uqw.1	+	22	3850	c.3850G>A	c.(3850-3852)GAG>AAG	p.E1284K	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_3'UTR	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1355						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TTTAGGGAAGGAGCACCGAAG	0.333			NA											13	173					0	0	0.00245	0	0
HECW2	57520	broad.mit.edu	37	2	197105193	197105193	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:197105193G>A	uc002utm.1	-	21	3927	c.3744C>T	c.(3742-3744)GTC>GTT	p.V1248V	HECW2_uc002utl.1_Silent_p.V892V	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1248	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CAACGAAGGTGACATATAGCT	0.473			NA											37	55					0	0	0.006999	0	0
NIF3L1	60491	broad.mit.edu	37	2	201760030	201760030	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:201760030C>T	uc002uwm.2	+	4	734	c.643C>T	c.(643-645)CAG>TAG	p.Q215*	NIF3L1_uc002uwl.2_Nonsense_Mutation_p.Q188*|NIF3L1_uc002uwn.2_Nonsense_Mutation_p.Q188*|NIF3L1_uc002uwo.2_Nonsense_Mutation_p.Q215*|NIF3L1_uc002uwp.2_Nonsense_Mutation_p.Q215*|NIF3L1_uc002uwq.2_Nonsense_Mutation_p.Q215*	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	215					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GAATTGTACTCAGAAGGCTTT	0.368			NA											51	118					0	0	0.01441	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202352615	202352615	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:202352615T>A	uc002uye.2	-	15	1640	c.1592A>T	c.(1591-1593)GAT>GTT	p.D531V	ALS2CR11_uc002uyf.2_Missense_Mutation_p.D1728V|ALS2CR11_uc010fti.2_3'UTR	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	531										large_intestine(1)|ovary(1)|skin(1)	3						CTCAAATTTATCTGAACAATC	0.294			NA											10	75					0	0	0.006214	0	0
NBEAL1	65065	broad.mit.edu	37	2	204000719	204000719	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:204000719C>G	uc002uzt.3	+	27	4379	c.4046C>G	c.(4045-4047)TCT>TGT	p.S1349C	NBEAL1_uc002uzs.3_Missense_Mutation_p.S59C	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1349							binding			ovary(1)|skin(1)	2						GAAGATAGCTCTGTGGGAGAA	0.408			NA											18	73					0	0	0.00499	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173357	207173357	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:207173357G>A	uc002vbp.2	+	5	4355	c.4105G>A	c.(4105-4107)GAT>AAT	p.D1369N		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1369							nucleic acid binding|zinc ion binding			ovary(3)	3						AGAAAGTTCTGATTCCAATGA	0.398			NA											7	58					0	0	0.001984	0	0
PRKAG3	53632	broad.mit.edu	37	2	219688556	219688556	+	Missense_Mutation	SNP	C	C	A	rs144562493	by1000genomes	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:219688556C>A	uc002vjb.1	-	13	1418	c.1399G>T	c.(1399-1401)GTG>TTG	p.V467L		NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	467	CBS 4.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGAGACCACGCCCAAGAGA	0.612			NA											29	47					7.26314e-15	8.55921e-15	0.007291	1	0
WDR69	164781	broad.mit.edu	37	2	228756020	228756020	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:228756020C>T	uc002vpn.1	+	4	387	c.308C>T	c.(307-309)TCG>TTG	p.S103L	WDR69_uc010zlw.1_Missense_Mutation_p.S88L|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	103	WD 1.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CTTAACAAATCGGGCTCATGG	0.299			NA											17	60					0	0	0.010504	0	0
INPP5D	3635	broad.mit.edu	37	2	234104107	234104107	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:234104107C>T	uc010zmo.1	+	23	2812	c.2659C>T	c.(2659-2661)CAC>TAC	p.H887Y	INPP5D_uc010zmp.1_Missense_Mutation_p.H886Y	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	887					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CCTCACCAGCCACGACCCCAT	0.567	NSCLC(82;1215 1426 16163 20348 41018)		NA											24	52					0	0	0.00278	0	0
SEPT2	4735	broad.mit.edu	37	2	242283227	242283227	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:242283227G>T	uc002wbc.2	+	10	1178	c.757G>T	c.(757-759)GTC>TTC	p.V253F	SEPT2_uc002wbd.2_Missense_Mutation_p.V253F|SEPT2_uc002wbf.2_Missense_Mutation_p.V253F|SEPT2_uc002wbg.2_Missense_Mutation_p.V253F|SEPT2_uc002wbh.2_Missense_Mutation_p.V263F|SEPT2_uc010zop.1_Missense_Mutation_p.V288F	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	253					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		AGGAAAGAAGGTCAGAGGCCG	0.502			NA											11	264					0.00010058	0.000105982	0.013537	1	0
STK25	10494	broad.mit.edu	37	2	242438131	242438131	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr2:242438131G>C	uc002wbm.2	-	7	1111	c.840C>G	c.(838-840)CTC>CTG	p.L280L	STK25_uc002wbk.2_Silent_p.L99L|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Silent_p.L280L|STK25_uc002wbo.2_Silent_p.L203L|STK25_uc010zos.1_Silent_p.L186L|STK25_uc010zot.1_Silent_p.L206L|STK25_uc002wbp.2_Silent_p.L280L|STK25_uc010fzo.2_Silent_p.L203L|STK25_uc010zou.1_Silent_p.L186L|STK25_uc010zov.1_Silent_p.L186L	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	280					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TGAGCTCCGTGAGGAAGGAGG	0.577	NSCLC(99;1100 1566 7679 28647 48345)		NA											15	59					0	0	0.006122	0	0
CDS2	8760	broad.mit.edu	37	20	5170746	5170746	+	Splice_Site	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:5170746A>G	uc002wls.2	+	13	1463	c.1206_splice	c.e13-2	p.R402_splice	CDS2_uc010zqt.1_Splice_Site|CDS2_uc002wlu.2_Splice_Site|CDS2_uc010zqu.1_Splice_Site_p.R282_splice|CDS2_uc002wlv.2_Splice_Site_p.R304_splice|CDS2_uc010zqv.1_Splice_Site_p.R172_splice	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2						phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						ATTCTGTTCCAGAGGCCCTAA	0.512			NA											22	28					0	0	0.014323	0	0
TASP1	55617	broad.mit.edu	37	20	13550200	13550200	+	Silent	SNP	T	T	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:13550200T>G	uc002woi.2	-	7	639	c.522A>C	c.(520-522)GCA>GCC	p.A174A	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Silent_p.A151A|TASP1_uc010zrj.1_Intron	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	174					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						CATGATCTACTGCCCATCTGT	0.323			NA											16	53					0	0	0.010504	0	0
RIN2	54453	broad.mit.edu	37	20	19937423	19937423	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:19937423C>G	uc002wro.1	+	3	359	c.323C>G	c.(322-324)GCA>GGA	p.A108G	RIN2_uc010gcu.1_Missense_Mutation_p.A108G|RIN2_uc010gcv.1_5'UTR	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	108	SH2.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GAGGAGGCAGCAGAGGTCCTG	0.592			NA											2	6					0	0	0.004672	0	0
CST1	1469	broad.mit.edu	37	20	23729677	23729677	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:23729677G>A	uc002wtp.2	-	2	389	c.318C>T	c.(316-318)TTC>TTT	p.F106F		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	106						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					GCTGTTCATGGAAGGCACAGG	0.577			NA											53	60					0	0	0.01441	0	0
CST2	1470	broad.mit.edu	37	20	23805871	23805871	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:23805871G>A	uc002wtq.1	-	2	333	c.318C>T	c.(316-318)TTC>TTT	p.F106F		NM_001322	NP_001313	P09228	CYTT_HUMAN	cystatin SA precursor	106						extracellular region	cysteine-type endopeptidase inhibitor activity				0						GCTGTTCATGGAAGGCACAGG	0.552	Pancreas(193;496 3017 22514 29918)		NA											6	129					0	0	0.001168	0	0
NINL	22981	broad.mit.edu	37	20	25457142	25457142	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:25457142T>A	uc002wux.1	-	17	2859	c.2785A>T	c.(2785-2787)AGC>TGC	p.S929C	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	929					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CCCGCTGCGCTCGCGCCGAAA	0.672			NA											5	14					0	0	0.000602	0	0
NINL	22981	broad.mit.edu	37	20	25477351	25477351	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:25477351C>G	uc002wux.1	-	10	1332	c.1258G>C	c.(1258-1260)GAG>CAG	p.E420Q	NINL_uc010gdn.1_Missense_Mutation_p.E420Q|NINL_uc010gdo.1_Missense_Mutation_p.E203Q|NINL_uc010ztf.1_Missense_Mutation_p.E436Q	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	420	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TCGTCCATCTCTTTCACAAAC	0.602			NA											11	62					0	0	0.008291	0	0
TPX2	22974	broad.mit.edu	37	20	30345357	30345357	+	Silent	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:30345357A>T	uc002wwp.1	+	3	776	c.78A>T	c.(76-78)GGA>GGT	p.G26G	TPX2_uc010gdv.1_Silent_p.G26G	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	26					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATGATGAAGGAGATACTCAAA	0.393			NA											27	41					0	0	0.00632	0	0
FAM83C	128876	broad.mit.edu	37	20	33875148	33875148	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:33875148G>T	uc010zux.1	-	4	1552	c.1434C>A	c.(1432-1434)CCC>CCA	p.P478P	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Silent_p.P133P	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	478										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GACCCCGCAGGGGGCTGGGCT	0.642			NA											17	47					1.99824e-07	2.19214e-07	0.00499	1	0
SPAG4	6676	broad.mit.edu	37	20	34207574	34207574	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:34207574G>A	uc002xdb.1	+	10	1100	c.983G>A	c.(982-984)CGA>CAA	p.R328Q	SPAG4_uc010zvi.1_Missense_Mutation_p.R251Q	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	328	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			CTGCCGGGCCGAGTGCAGCTG	0.652			NA											16	50					0	0	0.004007	0	0
ZHX3	23051	broad.mit.edu	37	20	39832861	39832861	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:39832861G>A	uc002xjs.1	-	3	1074	c.696C>T	c.(694-696)TTC>TTT	p.F232F	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Silent_p.F232F|ZHX3_uc002xjt.1_Silent_p.F232F|ZHX3_uc002xju.1_Silent_p.F232F|ZHX3_uc002xjv.1_Silent_p.F232F|ZHX3_uc002xjw.1_Silent_p.F232F|ZHX3_uc010ggg.1_Silent_p.F232F	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	232					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CCCCATTGATGAAGGAATGGT	0.557			NA											17	93					0	0	0.00499	0	0
GNAS	2778	broad.mit.edu	37	20	57415491	57415491	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:57415491G>A	uc002xzt.2	+	1	697	c.330G>A	c.(328-330)GAG>GAA	p.E110E	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	123					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TCGACTACGAGACCGAGAGCG	0.622	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			11	80					0	0	0.001855	0	0
GATA5	140628	broad.mit.edu	37	20	61048574	61048574	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:61048574A>C	uc002ycx.1	-	3	646	c.584T>G	c.(583-585)CTG>CGG	p.L195R		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	195	GATA-type 1.				blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CGGTGTGGACAGGGCCCCGCA	0.672			NA											3	5					0	0	0.009096	0	0
SRMS	6725	broad.mit.edu	37	20	62178612	62178612	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr20:62178612C>T	uc002yfi.1	-	1	246	c.205G>A	c.(205-207)GAG>AAG	p.E69K		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	69	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			ACACTCAGCTCCCCGCCACAC	0.697			NA											4	14					0	0	0.001168	0	0
TPTE	7179	broad.mit.edu	37	21	10906930	10906930	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr21:10906930C>A	uc002yip.1	-	24	1999	c.1631G>T	c.(1630-1632)AGT>ATT	p.S544I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.S526I|TPTE_uc002yir.1_Missense_Mutation_p.S506I|TPTE_uc010gkv.1_Missense_Mutation_p.S406I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	544					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACAACATCACTGGAAGTCAT	0.388			NA											18	47					1.87028e-06	2.03172e-06	0.012319	1	0
SON	6651	broad.mit.edu	37	21	34922480	34922480	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr21:34922480G>A	uc002yse.1	+	3	992	c.943G>A	c.(943-945)GAG>AAG	p.E315K	SON_uc002ysb.1_Missense_Mutation_p.E315K|SON_uc002ysc.2_Missense_Mutation_p.E315K|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	315					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GACACCTACTGAGGTGTACCC	0.478			NA									OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	62					0	0	0.004482	0	0
DSCAM	1826	broad.mit.edu	37	21	41725430	41725430	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr21:41725430T>A	uc002yyq.1	-	5	1348	c.896A>T	c.(895-897)TAC>TTC	p.Y299F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	299	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCAGTTCCGTATCTGTTGGA	0.512	Melanoma(134;970 1778 1785 21664 32388)		NA											19	130					0	0	0.014323	0	0
COL6A2	1292	broad.mit.edu	37	21	47545457	47545457	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr21:47545457C>T	uc002zia.1	+	25	1977	c.1895C>T	c.(1894-1896)ACA>ATA	p.T632I	COL6A2_uc002zhy.1_Missense_Mutation_p.T632I|COL6A2_uc002zhz.1_Missense_Mutation_p.T632I|COL6A2_uc002zib.1_Missense_Mutation_p.T38I|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	632	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCAACTTCACACTGGAGAAG	0.617			NA											29	34					0	0	0.007291	0	0
ARVCF	421	broad.mit.edu	37	22	19961246	19961246	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:19961246G>C	uc002zqz.2	-	13	2430	c.2159C>G	c.(2158-2160)TCT>TGT	p.S720C	ARVCF_uc002zqy.2_Missense_Mutation_p.S236C	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	720	ARM 8.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					GTCGGTCTCAGACTGCAGCAG	0.662			NA											5	71					0	0	0.001168	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226953	24226953	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:24226953G>A	uc002zyn.3	+	12	1507	c.1408G>A	c.(1408-1410)GAA>AAA	p.E470K	SLC2A11_uc002zym.3_Missense_Mutation_p.E477K|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Silent_p.R476R|SLC2A11_uc002zyp.3_Missense_Mutation_p.E473K	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	470	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GATCTCCAAGGAATTACACAG	0.562			NA											21	59					0	0	0.008871	0	0
RFPL1	5988	broad.mit.edu	37	22	29837589	29837589	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:29837589C>A	uc003afn.2	+	2	641	c.432C>A	c.(430-432)CTC>CTA	p.L144L	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	144	B30.2/SPRY.						zinc ion binding				0						CTGACGACCTCAGGAGCGTCC	0.502			NA											23	90					1.17739e-12	1.36341e-12	0.005443	1	0
SF3A1	10291	broad.mit.edu	37	22	30740986	30740986	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:30740986T>C	uc003ahl.2	-	4	719	c.587A>G	c.(586-588)GAC>GGC	p.D196G		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	196	SURP motif 2.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						GCGGAGAAAGTCAAACTGGTA	0.572			NA											59	61					0	0	0.01441	0	0
H1F0	3005	broad.mit.edu	37	22	38201558	38201558	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:38201558G>C	uc003aty.2	+	1	445	c.7G>C	c.(7-9)GAG>CAG	p.E3Q	GCAT_uc003atz.2_5'Flank|GCAT_uc003aua.1_5'Flank	NM_005318	NP_005309	P07305	H10_HUMAN	H1 histone family, member 0	3					DNA fragmentation involved in apoptotic nuclear change|nucleosome assembly	actin cytoskeleton|Golgi apparatus|nucleoplasm|nucleosome	DNA binding				0	Melanoma(58;0.045)					CACCATGACCGAGAATTCCAC	0.627	NSCLC(191;1872 2984 30230 41544)|Esophageal Squamous(4;11 371 39444 52196)		NA											8	33					0	0	0.00308	0	0
GCAT	23464	broad.mit.edu	37	22	38211274	38211274	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:38211274G>T	uc003atz.2	+	5	738	c.718G>T	c.(718-720)GGG>TGG	p.G240W	GCAT_uc003aua.1_Missense_Mutation_p.G266W	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	240					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGGCTTCCTGGGGCCCACAGG	0.617			NA											4	24					1.23904e-05	1.32442e-05	0.000602	1	0
TNFRSF13C	115650	broad.mit.edu	37	22	42321413	42321413	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:42321413A>G	uc003bbl.2	-	3	557	c.513T>C	c.(511-513)ACT>ACC	p.T171T	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Silent_p.T172T	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	171	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TCACCAGTTCAGTGGAGCCCA	0.677			NA											19	24					0	0	0.014323	0	0
WBP2NL	164684	broad.mit.edu	37	22	42418274	42418274	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:42418274G>C	uc011ape.1	+	6	444	c.428G>C	c.(427-429)AGA>ACA	p.R143T	WBP2NL_uc003bbt.2_Missense_Mutation_p.R143T|WBP2NL_uc011apk.1_Missense_Mutation_p.R15T|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	143					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						TTTCCACTTAGAACCTTAAAT	0.383			NA											20	84					0	0	0.012319	0	0
POLDIP3	84271	broad.mit.edu	37	22	42991591	42991591	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:42991591C>T	uc003bcu.2	-	6	942	c.843G>A	c.(841-843)AAG>AAA	p.K281K	POLDIP3_uc011app.1_Silent_p.K202K|POLDIP3_uc003bcv.2_Silent_p.K252K|POLDIP3_uc011apq.1_Silent_p.K298K|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	281	RRM.				positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TCACAGTCATCTTGGTGCCTT	0.448	Ovarian(52;967 1128 5875 19997 42537)		NA											6	48					0	0	0.001168	0	0
PACSIN2	11252	broad.mit.edu	37	22	43287087	43287087	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:43287087C>T	uc010gzg.2	-	4	541	c.319G>A	c.(319-321)GAT>AAT	p.D107N	PACSIN2_uc003bdg.3_Missense_Mutation_p.D107N|PACSIN2_uc003bde.3_Missense_Mutation_p.D107N|PACSIN2_uc003bdf.3_Missense_Mutation_p.D107N	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	107					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				TCGAAGTCATCGTTCATCAGT	0.572			NA											11	41					0	0	0.013537	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655967	46655967	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:46655967G>A	uc003bhh.2	-	1	3253	c.3253C>T	c.(3253-3255)CGT>TGT	p.R1085C		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1085	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATGACAAAACGAGGTGCCTGC	0.502			NA											7	31					0	0	0.00308	0	0
CELSR1	9620	broad.mit.edu	37	22	46787649	46787649	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:46787649G>C	uc003bhw.1	-	15	6029	c.6029C>G	c.(6028-6030)TCC>TGC	p.S2010C	CELSR1_uc011arc.1_Missense_Mutation_p.S331C	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2010	Extracellular (Potential).|Laminin EGF-like.|EGF-like 8; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCGGCTGTGGGAGCCATGGGG	0.632			NA											4	20					0	0	0.009096	0	0
CELSR1	9620	broad.mit.edu	37	22	46806436	46806436	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:46806436G>C	uc003bhw.1	-	7	4792	c.4792C>G	c.(4792-4794)CTA>GTA	p.L1598V	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1598	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCCAGGAGTAGAGGGCCGGTC	0.637			NA											15	39					0	0	0.003163	0	0
MOV10L1	54456	broad.mit.edu	37	22	50591507	50591507	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr22:50591507G>A	uc003bjj.2	+	22	3009	c.2926G>A	c.(2926-2928)GAG>AAG	p.E976K	MOV10L1_uc003bjk.3_Missense_Mutation_p.E976K|MOV10L1_uc011arp.1_Missense_Mutation_p.E956K|MOV10L1_uc003bjl.2_Missense_Mutation_p.E103K|MOV10L1_uc003bjm.1_Missense_Mutation_p.E19K	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	976					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCGGTCCCACGAGGCCCTGCT	0.587			NA											21	73					0	0	0.010504	0	0
SYN2	6854	broad.mit.edu	37	3	12046037	12046037	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:12046037C>T	uc003bwm.2	+	1	176	c.12C>T	c.(10-12)TTC>TTT	p.F4F	SYN2_uc003bwl.1_Silent_p.F4F	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	4					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						TGATGAACTTCCTGCGGCGCC	0.657			NA											4	8					0	0	0.00308	0	0
TSEN2	80746	broad.mit.edu	37	3	12531405	12531405	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:12531405G>C	uc003bxc.2	+	2	493	c.106G>C	c.(106-108)GAA>CAA	p.E36Q	TSEN2_uc003bwy.2_Missense_Mutation_p.E36Q|TSEN2_uc003bwz.2_Missense_Mutation_p.E36Q|TSEN2_uc003bxa.2_Missense_Mutation_p.E36Q|TSEN2_uc011auq.1_Missense_Mutation_p.E36Q|TSEN2_uc003bxb.2_Missense_Mutation_p.E36Q|TSEN2_uc011aur.1_5'UTR	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	36					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						TCCTCTGAAAGAATTCAAGAT	0.448			NA											13	64					0	0	0.001855	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713446	30713446	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:30713446G>C	uc003ceo.2	+	4	1153	c.771G>C	c.(769-771)GAG>GAC	p.E257D	TGFBR2_uc003cen.2_Missense_Mutation_p.E282D	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	257	Protein kinase.|Cytoplasmic (Potential).|ATP (By similarity).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GCTTTGCTGAGGTCTATAAGG	0.517			NA											8	53					0	0	0.004482	0	0
MLH1	4292	broad.mit.edu	37	3	37053541	37053541	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:37053541G>A	uc003cgl.2	+	8	688	c.628G>A	c.(628-630)GCC>ACC	p.A210T	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.A210T|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Missense_Mutation_p.A112T|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR|MLH1_uc010hgg.1_5'UTR|MLH1_uc010hgh.1_5'UTR|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_5'UTR|MLH1_uc010hgk.2_5'UTR|MLH1_uc010hgl.1_5'Flank	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	210					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						ACTACCCAATGCCTCAACCGT	0.383			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				14	54					0	0	0.00499	0	0
GOLGA4	2803	broad.mit.edu	37	3	37367527	37367527	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:37367527C>T	uc003cgv.2	+	14	4454	c.4150C>T	c.(4150-4152)CAA>TAA	p.Q1384*	GOLGA4_uc010hgr.1_Nonsense_Mutation_p.Q945*|GOLGA4_uc003cgw.2_Nonsense_Mutation_p.Q1406*|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Nonsense_Mutation_p.Q1265*	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1384	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TGTTCAGCTTCAAAATAGCAT	0.343			NA											9	28					0	0	0.004482	0	0
EXOG	9941	broad.mit.edu	37	3	38537932	38537932	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:38537932T>C	uc003cih.2	+	1	170	c.74T>C	c.(73-75)GTA>GCA	p.V25A	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.V25A|EXOG_uc003cij.2_5'UTR|EXOG_uc010hhd.2_5'UTR|EXOG_uc010hhe.2_5'UTR|EXOG_uc003cik.2_5'UTR|EXOG_uc010hhf.2_5'UTR|EXOG_uc003cii.2_5'UTR	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	25						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						GCTGGGGCTGTAGTGGGCGCT	0.637			NA									OREG0015479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	25					0	0	0.012319	0	0
LRRC2	79442	broad.mit.edu	37	3	46574379	46574379	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:46574379C>G	uc010hji.2	-	5	875	c.511G>C	c.(511-513)GAA>CAA	p.E171Q	LRRC2_uc003cpu.3_Missense_Mutation_p.E171Q	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	171	LRR 3.									ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		ACATTGAGTTCTTTCAGGTTC	0.348			NA											18	77					0	0	0.010504	0	0
PTPN23	25930	broad.mit.edu	37	3	47453061	47453061	+	Missense_Mutation	SNP	C	C	T	rs146178681	byFrequency	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:47453061C>T	uc003crf.1	+	20	3869	c.3773C>T	c.(3772-3774)CCG>CTG	p.P1258L	PTPN23_uc011baw.1_Missense_Mutation_p.P1223L|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.P1128L|uc003cri.2_5'Flank	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	1258	Tyrosine-protein phosphatase.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity	p.P1258L(1)		breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TACTGCCCCCCGCTAGTGGCA	0.577			NA											6	54					0	0	0.001984	0	0
COL7A1	1294	broad.mit.edu	37	3	48607742	48607742	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:48607742C>A	uc003ctz.2	-	97	7407	c.7406G>T	c.(7405-7407)GGG>GTG	p.G2469V		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2469	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTCGGGGCCCAGGCAGCCC	0.627			NA											26	39					9.22233e-05	9.73306e-05	0.004656	1	0
GMPPB	29925	broad.mit.edu	37	3	49759191	49759191	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:49759191G>A	uc003cxk.1	-	9	1302	c.1077C>T	c.(1075-1077)ATC>ATT	p.I359I	AMIGO3_uc003cxj.2_5'Flank|GMPPB_uc003cxl.1_Silent_p.I386I	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	359					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCCCTCACATGATGATACGAG	0.557			NA											5	31					0	0	0.001984	0	0
POC1A	25886	broad.mit.edu	37	3	52172224	52172224	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:52172224C>G	uc003dcu.2	-	7	1092	c.774G>C	c.(772-774)CTG>CTC	p.L258L	POC1A_uc003dcv.2_Silent_p.L220L|POC1A_uc003dcw.2_Silent_p.L258L	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	258	WD 6.					centriole|microtubule basal body					0						GGCCCTCCATCAGGTCCAGGA	0.602			NA											8	37					0	0	0.004482	0	0
DNAH1	25981	broad.mit.edu	37	3	52398911	52398911	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:52398911C>G	uc011bef.1	+	34	5655	c.5394C>G	c.(5392-5394)CTC>CTG	p.L1798L		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1798					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGGAGGACCTCAAGCTCTTCT	0.627			NA											13	51					0	0	0.013537	0	0
PTX3	5806	broad.mit.edu	37	3	157160592	157160592	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:157160592G>C	uc003fbl.3	+	3	1113	c.970G>C	c.(970-972)GAT>CAT	p.D324H	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	324	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TGGTGGCTTTGATGAAACATT	0.493			NA											10	88					0	0	0.008291	0	0
SI	6476	broad.mit.edu	37	3	164793764	164793764	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr3:164793764G>A	uc003fei.2	-	2	99	c.37C>T	c.(37-39)CTG>TTG	p.L13L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	13	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGGACAATCAGAGAGATTTCC	0.269			NA								HNSCC(35;0.089)			12	72					0	0	0.013537	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018245	1018245	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:1018245G>A	uc003gce.2	+	6	1026	c.865G>A	c.(865-867)GAG>AAG	p.E289K	FGFRL1_uc003gcf.2_Missense_Mutation_p.E289K|FGFRL1_uc003gcg.2_Missense_Mutation_p.E289K|FGFRL1_uc010ibo.2_Missense_Mutation_p.E289K	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	289	Ig-like C2-type 3.|Extracellular (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GTACGGCGCCGAGGGCCGCCA	0.657			NA											10	39					0	0	0.008291	0	0
ADD1	118	broad.mit.edu	37	4	2916722	2916722	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:2916722G>C	uc003gfr.2	+	13	1905	c.1717G>C	c.(1717-1719)GAG>CAG	p.E573Q	ADD1_uc003gfn.2_Intron|ADD1_uc003gfo.2_Missense_Mutation_p.E604Q|ADD1_uc003gfp.2_Missense_Mutation_p.E573Q|ADD1_uc003gfq.2_Missense_Mutation_p.E604Q|ADD1_uc003gfs.2_Missense_Mutation_p.E604Q	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	573					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCGTGAGCTGGAGGAGTACCG	0.602	Esophageal Squamous(71;505 1201 20414 34538 37449)		NA											6	28					0	0	0.001168	0	0
HS3ST1	9957	broad.mit.edu	37	4	11400759	11400759	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:11400759C>A	uc003gmq.2	-	2	1194	c.871G>T	c.(871-873)GAG>TAG	p.E291*		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	291						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						TTATTTGGCTCATGAAAATAT	0.488			NA											42	104					5.48756e-27	6.81602e-27	0.011902	1	0
SLIT2	9353	broad.mit.edu	37	4	20530616	20530616	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:20530616G>A	uc003gpr.1	+	16	1711	c.1507G>A	c.(1507-1509)GAT>AAT	p.D503N	SLIT2_uc003gps.1_Missense_Mutation_p.D495N	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	503	LRRNT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CTGCTTTGCGGATCTGGCTTG	0.398			NA											20	93					0	0	0.00333	0	0
SLIT2	9353	broad.mit.edu	37	4	20533668	20533668	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:20533668C>T	uc003gpr.1	+	17	1879	c.1675C>T	c.(1675-1677)CAA>TAA	p.Q559*	SLIT2_uc003gps.1_Nonsense_Mutation_p.Q551*	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	559	LRR 13.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GAAACTTCCTCAATTACGTAA	0.294			NA											7	14					0	0	0.00308	0	0
GPR125	166647	broad.mit.edu	37	4	22389690	22389690	+	Missense_Mutation	SNP	C	C	A	rs141222776		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:22389690C>A	uc003gqm.1	-	19	3869	c.3604G>T	c.(3604-3606)GTG>TTG	p.V1202L	GPR125_uc010ieo.1_Missense_Mutation_p.V1058L|GPR125_uc003gql.1_Missense_Mutation_p.V329L	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	1202	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				CCGTTCTGCACGCTTCCTTCC	0.527			NA											27	68					2.85442e-18	3.41812e-18	0.010818	1	0
SRD5A3	79644	broad.mit.edu	37	4	56236183	56236183	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:56236183C>G	uc003hau.2	+	5	977	c.882C>G	c.(880-882)CTC>CTG	p.L294L	uc003hav.1_Intron|uc003haw.1_Intron	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	294	Cytoplasmic (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CTGCCTTTCTCAGCCACCAAT	0.423			NA											5	101					0	0	0.001984	0	0
LPHN3	23284	broad.mit.edu	37	4	62845391	62845391	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:62845391G>T	uc010ihh.2	+	15	2885	c.2712G>T	c.(2710-2712)GGG>GGT	p.G904G	LPHN3_uc003hcq.3_Silent_p.G904G|LPHN3_uc003hct.2_Silent_p.G297G	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	891	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TTTTCCGGGGGCTCCAGAGTG	0.498			NA											72	85					3.41413e-29	4.26447e-29	0.01441	1	0
UGT2B10	7365	broad.mit.edu	37	4	69874758	69874758	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:69874758C>A	uc011cao.1	-	8	1149	c.1013G>T	c.(1012-1014)GGA>GTA	p.G338V	UGT2B10_uc011can.1_Missense_Mutation_p.G254V			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	375					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCCATTGGCTCCACCATGAGT	0.398	Melanoma(133;755 1763 25578 26334 46021)		NA											33	156					3.21399e-22	3.9048e-22	0.004878	1	0
UGT2B28	54490	broad.mit.edu	37	4	70156375	70156375	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:70156375C>A	uc003hej.2	+	5	1158	c.1156C>A	c.(1156-1158)CAT>AAT	p.H386N	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	386					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GGCAATCTACCATGGGATCCC	0.428			NA											39	442					8.16904e-11	9.25085e-11	0.007835	1	0
SULT1E1	6783	broad.mit.edu	37	4	70707720	70707720	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:70707720C>T	uc003heo.2	-	8	990	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	293					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						TCTTAGATCTCAGTTCGAAAC	0.303			NA											10	84					0	0	0.008291	0	0
GRSF1	2926	broad.mit.edu	37	4	71690060	71690060	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:71690060C>T	uc010iia.1	-	9	1502	c.1419G>A	c.(1417-1419)CTG>CTA	p.L473L	GRSF1_uc011caz.1_Silent_p.L355L|GRSF1_uc003hfs.2_Silent_p.L311L	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	473	RRM 3.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GACATGAATTCAGGAACAGTT	0.274			NA											3	15					0	0	0.004672	0	0
CCDC158	339965	broad.mit.edu	37	4	77292610	77292610	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:77292610T>A	uc003hkb.3	-	9	1262	c.1109A>T	c.(1108-1110)CAG>CTG	p.Q370L		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	370	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TCCAGATTCCTGACTGAATTG	0.373			NA											55	16					0	0	0.01441	0	0
BMP2K	55589	broad.mit.edu	37	4	79831813	79831813	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:79831813C>G	uc003hlk.2	+	16	2278	c.2112C>G	c.(2110-2112)GGC>GGG	p.G704G	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	704						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						AAGAAAATGGCACTGCAAACC	0.388			NA											29	21					0	0	0.005443	0	0
PDLIM5	10611	broad.mit.edu	37	4	95445019	95445019	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:95445019C>G	uc003hti.2	+	3	392	c.241C>G	c.(241-243)CTG>GTG	p.L81V	PDLIM5_uc003htf.2_Missense_Mutation_p.L81V|PDLIM5_uc003htg.2_Missense_Mutation_p.L81V|PDLIM5_uc011cdx.1_Missense_Mutation_p.L81V|PDLIM5_uc003hth.2_Missense_Mutation_p.L81V|PDLIM5_uc003htj.2_5'UTR|PDLIM5_uc003htk.2_Missense_Mutation_p.L81V|PDLIM5_uc011cdy.1_Intron	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	81	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		GAATATGACTCTGCAAAGGTA	0.393			NA											6	37					0	0	0.001168	0	0
COL25A1	84570	broad.mit.edu	37	4	110222978	110222978	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:110222978G>C	uc003hze.1	-	2	729	c.198C>G	c.(196-198)CTC>CTG	p.L66L	COL25A1_uc003hzg.2_Silent_p.L66L|COL25A1_uc003hzh.1_Silent_p.L66L	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	66	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TGGCGGATTCGAGAGCGGCGA	0.602			NA											10	162					0	0	0.008291	0	0
ANK2	287	broad.mit.edu	37	4	114278095	114278095	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:114278095G>T	uc003ibe.3	+	38	8421	c.8321G>T	c.(8320-8322)GGC>GTC	p.G2774V	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.G76V|ANK2_uc011cgb.1_Missense_Mutation_p.G2789V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2741					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTGTGATGGCCATGGATGT	0.488			NA											14	102					6.31663e-08	6.96395e-08	0.003163	1	0
SMARCA5	8467	broad.mit.edu	37	4	144467174	144467174	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:144467174G>C	uc003ijg.2	+	19	2956	c.2494G>C	c.(2494-2496)GAG>CAG	p.E832Q		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	832					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					TGAAGAGTTAGAGGAAAAAGA	0.383			NA											16	45					0	0	0.004007	0	0
GYPA	2993	broad.mit.edu	37	4	145061855	145061855	+	Translation_Start_Site	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:145061855G>T	uc003ijo.3	-	1	50	c.-66C>A	c.(-68--64)CACTG>CAATG		GYPA_uc003ijn.2_Translation_Start_Site|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Translation_Start_Site|GYPA_uc003ijp.3_Translation_Start_Site|GYPA_uc010ioq.2_Translation_Start_Site|GYPA_uc010ior.2_Translation_Start_Site|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor						interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					GCAAGTGTCAGTGTCTGACCT	0.433			NA											6	15					2.7689e-08	3.06278e-08	0.001984	1	0
SH3D19	152503	broad.mit.edu	37	4	152054279	152054279	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:152054279C>T	uc010ipl.1	-	17	2915	c.1825G>A	c.(1825-1827)GCC>ACC	p.A609T	SH3D19_uc003imb.2_Missense_Mutation_p.A364T|SH3D19_uc003imc.2_Missense_Mutation_p.A550T|SH3D19_uc003ime.2_Missense_Mutation_p.A586T|SH3D19_uc010ipm.2_Missense_Mutation_p.A586T	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	609	SH3 3.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TCTCCTCTGGCCCATTCCTCA	0.428			NA											6	122					0	0	0.001168	0	0
DCHS2	54798	broad.mit.edu	37	4	155312413	155312413	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:155312413C>G	uc003inw.2	-	1	37	c.37G>C	c.(37-39)GAC>CAC	p.D13H	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	13					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ttttctccgtcttcattctct	0.144			NA											6	35					0	0	0.001168	0	0
GLRB	2743	broad.mit.edu	37	4	158091631	158091631	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:158091631G>A	uc003ipj.2	+	10	1447	c.1245G>A	c.(1243-1245)CTG>CTA	p.L415L		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	415	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AGTCTGATCTGAGATCTAATG	0.338			NA											48	38					0	0	0.01441	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160244634	160244634	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:160244634C>T	uc003iqg.3	+	5	841	c.531C>T	c.(529-531)CTC>CTT	p.L177L		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	177	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CAGTGATTCTCAATGGATCTG	0.398			NA											6	106					0	0	0.00308	0	0
CPE	1363	broad.mit.edu	37	4	166405735	166405735	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:166405735G>T	uc003irg.3	+	5	1229	c.952G>T	c.(952-954)GCT>TCT	p.A318S		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	318					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAACGGTGGTGCTTGGTACAG	0.453			NA											49	135					1.19451e-25	1.47544e-25	0.01441	1	0
PALLD	23022	broad.mit.edu	37	4	169433199	169433199	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:169433199A>G	uc011cjx.1	+	2	755	c.544A>G	c.(544-546)ATA>GTA	p.I182V	PALLD_uc003iru.2_Missense_Mutation_p.I182V	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	182					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GCTAACATCCATATTTAAAGC	0.502	Esophageal Squamous(109;1482 1532 18347 40239 51172)		NA							Pancreatic_Cancer_Familial_Clustering_of				24	79					0	0	0.005443	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912946	170912946	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:170912946C>T	uc003isp.3	-	3	991	c.813G>A	c.(811-813)GTG>GTA	p.V271V	MFAP3L_uc003isn.3_Silent_p.V168V	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	271	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		GAGTATGCCTCACAAAATTCT	0.592			NA											23	47					0	0	0.005443	0	0
ASB5	140458	broad.mit.edu	37	4	177142365	177142365	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr4:177142365G>A	uc003iuq.1	-	5	627	c.611C>T	c.(610-612)CCT>CTT	p.P204L	ASB5_uc003iup.1_Missense_Mutation_p.P151L	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	204	ANK 5.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TACATAGAGAGGAGTTCCCAA	0.413			NA											18	19					0	0	0.007413	0	0
KIAA0947	23379	broad.mit.edu	37	5	5473764	5473764	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:5473764G>A	uc003jdm.3	+	16	6538	c.6316G>A	c.(6316-6318)GGT>AGT	p.G2106S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2106										ovary(1)|central_nervous_system(1)	2						TGAAAAATTTGGTGAAGACCT	0.398			NA											7	40					0	0	0.001984	0	0
TRIO	7204	broad.mit.edu	37	5	14291313	14291313	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:14291313G>A	uc003jff.2	+	5	1035	c.1029G>A	c.(1027-1029)AGG>AGA	p.R343R	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.R294R|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	343	Spectrin 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCCAGCTGAGGCTGTTTGAAC	0.587			NA											26	63					0	0	0.00333	0	0
CDH10	1008	broad.mit.edu	37	5	24509699	24509699	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:24509699G>T	uc003jgr.1	-	7	1564	c.1232C>A	c.(1231-1233)CCA>CAA	p.P411Q	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	411	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AATAGAATCTGGGTCCCTTGC	0.308			NA								HNSCC(23;0.051)			13	88					8.60227e-14	1.0031e-13	0.004007	1	0
AGXT2	64902	broad.mit.edu	37	5	35037091	35037091	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:35037091C>G	uc003jjf.2	-	4	521	c.442G>C	c.(442-444)GAA>CAA	p.E148Q	AGXT2_uc011com.1_Missense_Mutation_p.E148Q|AGXT2_uc011con.1_Missense_Mutation_p.E56Q	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	148					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	TCTGCATATTCATGCATTGGA	0.488			NA											8	75					0	0	0.008291	0	0
PRLR	5618	broad.mit.edu	37	5	35065601	35065601	+	Missense_Mutation	SNP	C	C	T	rs139147779		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:35065601C>T	uc003jjm.2	-	10	1989	c.1459G>A	c.(1459-1461)GAC>AAC	p.D487N	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Missense_Mutation_p.D386N	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	487	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GTATCCTGGTCAGTCTCAGAA	0.493			NA											19	120					0	0	0.008871	0	0
LIFR	3977	broad.mit.edu	37	5	38510737	38510737	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:38510737G>C	uc010ive.1	-	7	1152	c.820C>G	c.(820-822)CAA>GAA	p.Q274E	LIFR_uc003jli.2_Missense_Mutation_p.Q274E	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	274	Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					ACTTTTTCTTGACTCACACAA	0.378	Melanoma(13;4 730 6426 9861 34751)		NA	T	PLAG1	salivary adenoma								10	54					0	0	0.008291	0	0
PTGER4	5734	broad.mit.edu	37	5	40692198	40692198	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:40692198C>T	uc003jlz.2	+	3	1777	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	395	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						CTCAGACCCTCCTGCCAGACC	0.567			NA											21	49					0	0	0.00333	0	0
PRKAA1	5562	broad.mit.edu	37	5	40765169	40765169	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:40765169C>G	uc003jmc.2	-	7	999	c.993G>C	c.(991-993)TTG>TTC	p.L331F	PRKAA1_uc003jmb.2_Missense_Mutation_p.L346F	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	331					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	AGGCAACTGCCAAAGGATCCT	0.388			NA											16	122					0	0	0.004007	0	0
GHR	2690	broad.mit.edu	37	5	42718993	42718993	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:42718993G>A	uc003jmt.2	+	10	1427	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	GHR_uc011cpq.1_Missense_Mutation_p.E275K	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	462	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ACTTCCTACTGAAGGAGCTGA	0.453			NA											18	75					0	0	0.006122	0	0
MRPS30	10884	broad.mit.edu	37	5	44809664	44809664	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:44809664C>T	uc003joh.2	+	1	638	c.600C>T	c.(598-600)CTC>CTT	p.L200L	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	200					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					CTGCCGCCCTCGGTGAGCCTT	0.607			NA											10	61					0	0	0.013537	0	0
ITGA2	3673	broad.mit.edu	37	5	52362956	52362956	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:52362956G>C	uc003joy.2	+	16	2095	c.1952G>C	c.(1951-1953)AGT>ACT	p.S651T	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.S575T|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	651	FG-GAP 7.|Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AGGTCACAAAGTATTGCTGAT	0.373			NA											9	46					0	0	0.006214	0	0
KIF2A	3796	broad.mit.edu	37	5	61651013	61651013	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:61651013G>A	uc003jsy.3	+	7	897	c.586G>A	c.(586-588)GAA>AAA	p.E196K	KIF2A_uc003jsz.3_Missense_Mutation_p.E196K|KIF2A_uc010iwp.2_Missense_Mutation_p.E177K|KIF2A_uc003jsx.3_Missense_Mutation_p.E176K|KIF2A_uc010iwq.2_5'UTR	NM_004520	NP_004511	O00139	KIF2A_HUMAN	kinesin heavy chain member 2 isoform 1	196	Globular (Potential).				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		CCCAAATTATGAAATTATGTG	0.299			NA											17	54					0	0	0.008871	0	0
MSH3	4437	broad.mit.edu	37	5	80171579	80171579	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:80171579C>G	uc003kgz.2	+	24	3565	c.3312C>G	c.(3310-3312)CTC>CTG	p.L1104L		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	1104					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GAAAGAGACTCAAGTATTTTG	0.363	Melanoma(88;1010 1399 13793 26548 36275)		NA						MMR					9	45					0	0	0.010729	0	0
VCAN	1462	broad.mit.edu	37	5	82786003	82786003	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:82786003C>A	uc003kii.3	+	3	513	c.157C>A	c.(157-159)CCA>ACA	p.P53T	VCAN_uc003kij.3_Missense_Mutation_p.P53T|VCAN_uc010jau.2_Missense_Mutation_p.P53T|VCAN_uc003kik.3_Missense_Mutation_p.P53T|VCAN_uc003kih.3_Missense_Mutation_p.P53T	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	53	Ig-like V-type.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCCTACTTTGCCACCCAGTTA	0.453			NA											39	65					4.92203e-23	6.04602e-23	0.00623	1	0
CAST	831	broad.mit.edu	37	5	96093323	96093323	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:96093323G>A	uc003klz.1	+	22	1711	c.1549G>A	c.(1549-1551)GAG>AAG	p.E517K	CAST_uc003klt.2_Missense_Mutation_p.E504K|CAST_uc003klu.2_Missense_Mutation_p.E600K|CAST_uc003klv.2_Missense_Mutation_p.E578K|CAST_uc003klw.2_Missense_Mutation_p.E581K|CAST_uc003klx.2_Missense_Mutation_p.E559K|CAST_uc003kly.2_Missense_Mutation_p.E565K|CAST_uc011cuo.1_Missense_Mutation_p.E563K|CAST_uc011cur.1_Missense_Mutation_p.E503K|CAST_uc011cus.1_Missense_Mutation_p.E504K|CAST_uc003kma.1_Missense_Mutation_p.E476K|CAST_uc011cut.1_Missense_Mutation_p.E445K|CAST_uc003kmb.2_Missense_Mutation_p.E463K|CAST_uc003kmc.2_Missense_Mutation_p.E517K|CAST_uc003kmd.2_Missense_Mutation_p.E495K|CAST_uc003kme.2_Missense_Mutation_p.E476K|CAST_uc003kmf.2_Missense_Mutation_p.E482K|CAST_uc003kmh.2_Missense_Mutation_p.E232K|CAST_uc010jbj.2_Missense_Mutation_p.E232K|CAST_uc010jbk.2_Missense_Mutation_p.E232K|CAST_uc010jbl.1_Missense_Mutation_p.E240K|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.E240K|CAST_uc003kmk.2_RNA	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	517							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGCTTTGTCTGAGGACTTCTC	0.343			NA											12	59					0	0	0.001855	0	0
ALDH7A1	501	broad.mit.edu	37	5	125896781	125896781	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:125896781T>C	uc003ktx.2	-	10	1099	c.907A>G	c.(907-909)ATT>GTT	p.I303V	ALDH7A1_uc003ktv.2_5'UTR|ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.I330V	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	303					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TTACCAATAATGGCATTGTTT	0.363			NA											17	100					0	0	0.006122	0	0
CTXN3	613212	broad.mit.edu	37	5	126993409	126993409	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:126993409G>C	uc003kul.3	+	3	770	c.196G>C	c.(196-198)GAT>CAT	p.D66H	CTXN3_uc003kum.3_Missense_Mutation_p.D66H	NM_001048252	NP_001041717	Q4LDR2	CTXN3_HUMAN	cortexin 3	66						integral to membrane					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0128)|COAD - Colon adenocarcinoma(49;0.0234)|OV - Ovarian serous cystadenocarcinoma(64;0.038)		TACCTGGGCTGATGGACTTGA	0.488			NA											9	70					0	0	0.008291	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630476	131630476	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:131630476C>G	uc003kwq.2	+	1	332	c.167C>G	c.(166-168)GCG>GGG	p.A56G	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	56	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCGGACGCCGCGAACCTGAGC	0.682			NA											13	43					0	0	0.001855	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175984	140175984	+	Missense_Mutation	SNP	G	G	T	rs17844250		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:140175984G>T	uc003lhd.2	+	1	1541	c.1435G>T	c.(1435-1437)GCG>TCG	p.A479S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A479S|PCDHA2_uc011czy.1_Missense_Mutation_p.A479S	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGTGTCAGCGTGGGATGC	0.657			NA											41	69					7.05121e-23	8.62965e-23	0.010771	1	0
PCDHA5	56143	broad.mit.edu	37	5	140203212	140203212	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:140203212C>T	uc003lhl.2	+	1	1852	c.1852C>T	c.(1852-1854)CGC>TGC	p.R618C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R618C|PCDHA5_uc003lhj.1_Missense_Mutation_p.R618C	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	618	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGTGCGCGCATCCCGTT	0.652			NA											32	53					0	0	0.003755	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736861	140736861	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:140736861C>T	uc003ljq.1	+	1	2094	c.2094C>T	c.(2092-2094)GCC>GCT	p.A698A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Silent_p.A698A|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	698	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGTGGCCGCTGTCTCCT	0.607			NA											16	29					0	0	0.007413	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751042	140751042	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:140751042G>T	uc003ljw.1	+	1	1081	c.1081G>T	c.(1081-1083)GAG>TAG	p.E361*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.E361*|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	361	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAGATGCTGAGCTGGGGAC	0.403			NA											8	15					5.18039e-06	5.5821e-06	0.00308	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140764134	140764134	+	Silent	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:140764134T>C	uc003lka.1	+	1	1668	c.1668T>C	c.(1666-1668)AAT>AAC	p.N556N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.N556N	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	556	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCAGAATGACAACCCGC	0.602			NA											34	111					0	0	0.004878	0	0
NR3C1	2908	broad.mit.edu	37	5	142779799	142779799	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:142779799C>T	uc003lmz.2	-	2	1098	c.606G>A	c.(604-606)GGG>GGA	p.G202G	NR3C1_uc003lmy.2_Silent_p.G202G|NR3C1_uc003lna.2_Silent_p.G202G|NR3C1_uc003lnb.2_Silent_p.G202G|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Silent_p.G202G|NR3C1_uc003lnd.2_Silent_p.G202G|NR3C1_uc003lne.2_Silent_p.G202G|NR3C1_uc003lnf.2_Silent_p.G202G|NR3C1_uc003lng.2_Silent_p.G202G|NR3C1_uc003lnh.2_Silent_p.G202G|NR3C1_uc003lni.2_Silent_p.G202G	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	202	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TACCTGGGGACCCAGAAGAAA	0.463			NA											9	42					0	0	0.006214	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997621	146997621	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:146997621G>C	uc003loq.1	-	19	2581	c.2199C>G	c.(2197-2199)ATC>ATG	p.I733M	JAKMIP2_uc011dbx.1_Missense_Mutation_p.I691M|JAKMIP2_uc003lor.1_Missense_Mutation_p.I712M|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.I733M	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	733	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCAAACTTGATAACAGTTT	0.403			NA											33	54					0	0	0.00623	0	0
SYNPO	11346	broad.mit.edu	37	5	150028936	150028936	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:150028936C>T	uc003lsn.2	+	3	2205	c.1831C>T	c.(1831-1833)CTG>TTG	p.L611L	SYNPO_uc003lso.3_Silent_p.L367L|SYNPO_uc003lsp.2_Silent_p.L367L	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	611					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACGGGCATTCTGGAGGAGTC	0.582			NA											13	75					0	0	0.004007	0	0
PANK3	79646	broad.mit.edu	37	5	167993025	167993025	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:167993025C>A	uc003lzz.1	-	3	928	c.628G>T	c.(628-630)GGG>TGG	p.G210W		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	210					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TACCTTGTCCCAGTCACTCGT	0.368			NA											46	80					8.72198e-27	1.08133e-26	0.01441	1	0
SLIT3	6586	broad.mit.edu	37	5	168233492	168233492	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:168233492C>G	uc003mab.2	-	9	1314	c.894G>C	c.(892-894)TTG>TTC	p.L298F	SLIT3_uc010jjg.2_Missense_Mutation_p.L298F|SLIT3_uc010jji.2_Missense_Mutation_p.L298F|SLIT3_uc003mac.1_Missense_Mutation_p.L95F	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	298	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAATCTCCATCAAGCCCTTTC	0.587	Ovarian(29;311 847 10864 17279 24903)		NA											16	68					0	0	0.007413	0	0
DDX41	51428	broad.mit.edu	37	5	176939118	176939118	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr5:176939118C>G	uc003mho.2	-	16	1732	c.1711G>C	c.(1711-1713)GAG>CAG	p.E571Q	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhk.2_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.E351Q|DDX41_uc003mhn.2_Missense_Mutation_p.E440Q|DDX41_uc003mhp.2_Missense_Mutation_p.E440Q	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	571					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			AGCATGGACTCATCCCCGCAA	0.617			NA											19	97					0	0	0.012319	0	0
DUSP22	56940	broad.mit.edu	37	6	348125	348125	+	Missense_Mutation	SNP	G	G	A	rs138056339	byFrequency	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:348125G>A	uc003msx.2	+	6	725	c.286G>A	c.(286-288)GTG>ATG	p.V96M	DUSP22_uc011dhn.1_Missense_Mutation_p.V96M|DUSP22_uc003msy.1_Missense_Mutation_p.V53M	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	96	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CTCCAGGAGCGTGACACTGGT	0.612			NA											22	192					0	0	0.012319	0	0
DSP	1832	broad.mit.edu	37	6	7583579	7583579	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:7583579A>G	uc003mxp.1	+	24	6363	c.6084A>G	c.(6082-6084)AAA>AAG	p.K2028K	DSP_uc003mxq.1_Silent_p.K1429K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2028	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTAAGGAAAAATACTCTTTGG	0.483			NA											28	38					0	0	0.005443	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123906	12123906	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:12123906C>G	uc003nac.2	+	4	4057	c.3878C>G	c.(3877-3879)TCA>TGA	p.S1293*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1293					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GAACATTCCTCAACAGAATCG	0.458			NA											9	90					0	0	0.006214	0	0
JARID2	3720	broad.mit.edu	37	6	15517468	15517468	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:15517468G>A	uc003nbj.2	+	17	3771	c.3527G>A	c.(3526-3528)CGA>CAA	p.R1176Q	JARID2_uc011div.1_Missense_Mutation_p.R1004Q	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1176					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGTCCTGCCGAGGGCTGAAG	0.617			NA											20	103					0	0	0.012319	0	0
HIST1H2BF	8343	broad.mit.edu	37	6	26199818	26199818	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:26199818C>T	uc003ngx.2	+	1	32	c.32C>T	c.(31-33)CCA>CTA	p.P11L	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	11					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				GCTCCTGCTCCAAAAAAGGGC	0.488			NA											44	85					0	0	0.009718	0	0
GPX5	2880	broad.mit.edu	37	6	28500165	28500165	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:28500165G>T	uc003nll.2	+	4	429	c.427G>T	c.(427-429)GAA>TAA	p.E143*	GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	143					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	TGTGAATGGTGAAAAAGAACA	0.443			NA											52	57					4.45325e-31	5.57283e-31	0.01441	1	0
OR12D3	81797	broad.mit.edu	37	6	29342268	29342268	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:29342268G>C	uc003nme.2	-	1	801	c.797C>G	c.(796-798)TCC>TGC	p.S266C		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						CTGAATCATGGAGGTGGCTGA	0.483			NA											8	69					0	0	0.004482	0	0
HLA-J	3137	broad.mit.edu	37	6	29977359	29977359	+	Missense_Mutation	SNP	G	G	A	rs146982767	by1000genomes	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:29977359G>A	uc003rtl.3	+	5	740	c.378G>A	c.(376-378)ATG>ATA	p.M126I	HLA-G_uc011dmb.1_3'UTR|NCRNA00171_uc011dme.1_Intron|HLA-J_uc003nou.3_RNA|HLA-J_uc003nov.3_RNA					Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:4694038).												0						ATTTGTTCATGCCTTCCCTTT	0.453			NA											8	60					0	0	0.00308	0	0
GTF2H4	2968	broad.mit.edu	37	6	30880223	30880223	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:30880223C>T	uc003nsa.1	+	11	1284	c.1077C>T	c.(1075-1077)ATC>ATT	p.I359I	GTF2H4_uc003nsb.1_Silent_p.I197I|GTF2H4_uc011dmw.1_Silent_p.I365I|VARS2_uc003nsc.1_5'Flank|VARS2_uc003nsd.2_5'Flank|VARS2_uc011dmx.1_5'Flank|VARS2_uc011dmy.1_5'Flank|VARS2_uc011dmz.1_5'Flank|VARS2_uc011dna.1_5'Flank|VARS2_uc011dnb.1_5'Flank|VARS2_uc011dnc.1_5'Flank	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	359					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						CCAGTGGCATCACAGCCCAGC	0.602			NA						NER					33	72					0	0	0.003755	0	0
BAT5	7920	broad.mit.edu	37	6	31671053	31671053	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:31671053C>T	uc003nvy.1	-	1	36	c.6G>A	c.(4-6)GCG>GCA	p.A2A	BAT5_uc003nvx.1_5'Flank|BAT5_uc011dny.1_5'Flank|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_Intron|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_5'UTR	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	2						integral to membrane	hydrolase activity|protein binding				0						TCAGCAGCTTCGCCATGGCCC	0.692			NA											6	39					0	0	0.001168	0	0
RXRB	6257	broad.mit.edu	37	6	33164323	33164323	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:33164323C>G	uc003odb.2	-	5	1060	c.881G>C	c.(880-882)GGA>GCA	p.G294A	RXRB_uc003odc.2_Missense_Mutation_p.G294A|RXRB_uc003odd.2_Missense_Mutation_p.G198A|RXRB_uc011dqr.1_Missense_Mutation_p.G104A|RXRB_uc011dqs.1_Missense_Mutation_p.G177A|RXRB_uc003ode.1_Missense_Mutation_p.G158A|RXRB_uc011dqt.1_Missense_Mutation_p.G294A|RXRB_uc011dqu.1_Missense_Mutation_p.G198A	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	294	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CTCGGGGGCTCCCCCAGCCCC	0.632			NA											18	105					0	0	0.007413	0	0
KIFC1	3833	broad.mit.edu	37	6	33373380	33373380	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:33373380G>A	uc003oef.3	+	7	1958	c.1508G>A	c.(1507-1509)CGA>CAA	p.R503Q	KIFC1_uc011drf.1_Missense_Mutation_p.R495Q	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	503	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						ACCAATGCTCGATATGTCCCT	0.612			NA											6	26					0	0	0.001168	0	0
PHF1	5252	broad.mit.edu	37	6	33382112	33382112	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:33382112C>G	uc003oeh.2	+	9	1081	c.845C>G	c.(844-846)TCT>TGT	p.S282C	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.S282C|PHF1_uc010jux.2_Missense_Mutation_p.S82C	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	282					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CCCTTCACTTCTGAGAATTGG	0.493			NA									OREG0017346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	88					0	0	0.000602	0	0
MAPK13	5603	broad.mit.edu	37	6	36099123	36099123	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:36099123C>T	uc003ols.2	+	2	293	c.195C>T	c.(193-195)TTC>TTT	p.F65F	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	65	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						CCGAGATCTTCGCCAAGCGCG	0.662			NA											14	92					0	0	0.00499	0	0
C6orf89	221477	broad.mit.edu	37	6	36867275	36867275	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:36867275G>T	uc003omx.2	+	3	339	c.55G>T	c.(55-57)GAT>TAT	p.D19Y	C6orf89_uc003omv.2_5'UTR|C6orf89_uc003omw.2_Missense_Mutation_p.D26Y|C6orf89_uc011dtr.1_5'UTR	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	19						integral to membrane				ovary(1)	1						AGAGACTGTTGATTTGGTGAG	0.433			NA											22	111					5.45024e-15	6.44559e-15	0.00333	1	0
MDGA1	266727	broad.mit.edu	37	6	37622594	37622594	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:37622594G>A	uc003onu.1	-	5	1873	c.694C>T	c.(694-696)CGG>TGG	p.R232W	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	232					brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						TTGGTGAGCCGGAAGGTGATG	0.592			NA											58	153					0	0	0.01441	0	0
BTBD9	114781	broad.mit.edu	37	6	38545402	38545402	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:38545402T>A	uc003ooa.3	-	7	1704	c.1128A>T	c.(1126-1128)AAA>AAT	p.K376N	BTBD9_uc003ony.3_Missense_Mutation_p.K308N|BTBD9_uc010jwv.2_Missense_Mutation_p.K308N|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.K376N	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	376					cell adhesion						0						GAAAATATAATTTCTGCCAAG	0.368			NA											17	79					0	0	0.008871	0	0
CUL7	9820	broad.mit.edu	37	6	43019473	43019473	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:43019473C>G	uc003otq.2	-	3	912	c.609G>C	c.(607-609)CTG>CTC	p.L203L	CUL7_uc011dvb.1_Silent_p.L287L|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	203					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CTTGTTGGCTCAGTGACAGAA	0.512			NA											12	164					0	0	0.001855	0	0
CUL9	23113	broad.mit.edu	37	6	43174229	43174229	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:43174229C>T	uc003ouk.2	+	26	5268	c.5193C>T	c.(5191-5193)TTC>TTT	p.F1731F	CUL9_uc003oul.2_Silent_p.F1731F|CUL9_uc010jyk.2_Silent_p.F883F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1731					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TTGACCGTTTCTCCAGTTTCT	0.552			NA											5	95					0	0	0.001168	0	0
ABCC10	89845	broad.mit.edu	37	6	43411937	43411937	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:43411937G>T	uc003ouy.1	+	12	2750	c.2535G>T	c.(2533-2535)GAG>GAT	p.E845D	ABCC10_uc003ouz.1_Missense_Mutation_p.E817D|ABCC10_uc010jyo.1_Translation_Start_Site	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	845						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AAACAAAGGAGGGGCTGGAGG	0.552			NA											10	23					7.48243e-07	8.14157e-07	0.006214	1	0
SUPT3H	8464	broad.mit.edu	37	6	44900479	44900479	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:44900479C>G	uc003oxo.2	-	12	1174	c.856G>C	c.(856-858)GAG>CAG	p.E286Q	SUPT3H_uc003oxn.1_Missense_Mutation_p.E275Q|SUPT3H_uc011dvv.1_Missense_Mutation_p.E123Q|SUPT3H_uc003oxp.2_Missense_Mutation_p.E275Q|SUPT3H_uc011dvw.1_Missense_Mutation_p.E189Q	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	357					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						CTGTGAGCCTCAACACCACAG	0.453			NA											5	35					0	0	0.000602	0	0
GPR116	221395	broad.mit.edu	37	6	46851846	46851846	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:46851846C>A	uc003oyo.3	-	5	780	c.491G>T	c.(490-492)TGC>TTC	p.C164F	GPR116_uc003oyp.3_Missense_Mutation_p.C164F|GPR116_uc003oyq.3_Missense_Mutation_p.C164F|GPR116_uc003oyr.2_Missense_Mutation_p.C164F	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	164	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTGAAGCAGGCAAAAAGGTCC	0.383	NSCLC(59;410 1274 8751 36715 50546)		NA											40	91					1.22674e-20	1.48232e-20	0.00874	1	0
BMP5	653	broad.mit.edu	37	6	55638877	55638877	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:55638877G>A	uc003pcq.2	-	4	1709	c.997C>T	c.(997-999)CAG>TAG	p.Q333*	BMP5_uc011dxf.1_Nonsense_Mutation_p.Q333*	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	333					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAGGAGTCCTGATGAGAGCTG	0.468			NA											11	70					0	0	0.010729	0	0
COL9A1	1297	broad.mit.edu	37	6	70935635	70935635	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:70935635C>A	uc003pfg.3	-	37	2740	c.2581G>T	c.(2581-2583)GGT>TGT	p.G861C	COL9A1_uc003pfe.3_Missense_Mutation_p.G410C|COL9A1_uc003pff.3_Missense_Mutation_p.G618C	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	861	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						ACACACTTACCTGGGAGACCT	0.433			NA											37	54					6.68952e-21	8.09784e-21	0.013114	1	0
COL9A1	1297	broad.mit.edu	37	6	70964208	70964208	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:70964208G>A	uc003pfg.3	-	25	1849	c.1690C>T	c.(1690-1692)CCT>TCT	p.P564S	COL9A1_uc003pfe.3_Missense_Mutation_p.P137S|COL9A1_uc003pff.3_Missense_Mutation_p.P321S	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	564	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GCATCACCAGGAGGCCCAGGT	0.388			NA											17	67					0	0	0.010504	0	0
COL12A1	1303	broad.mit.edu	37	6	75804895	75804895	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:75804895C>A	uc003phs.2	-	60	8744	c.8578G>T	c.(8578-8580)GGA>TGA	p.G2860*	COL12A1_uc003pht.2_Nonsense_Mutation_p.G1696*	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2860	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCTGGGCTTCCCTACAACACA	0.473			NA											17	32					2.4624e-09	2.75574e-09	0.008871	1	0
SYNCRIP	10492	broad.mit.edu	37	6	86351130	86351130	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:86351130C>T	uc003pla.2	-	2	569	c.28G>A	c.(28-30)GGT>AGT	p.G10S	SYNCRIP_uc003pku.2_Missense_Mutation_p.G10S|SYNCRIP_uc003pkw.2_Missense_Mutation_p.G10S|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Missense_Mutation_p.G10S|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Missense_Mutation_p.G10S	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	10					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		TCTTCAGTACCATTTCCATTA	0.358			NA											12	47					0	0	0.003163	0	0
GABRR1	2569	broad.mit.edu	37	6	89907945	89907945	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:89907945G>A	uc003pna.2	-	5	821	c.366C>T	c.(364-366)CTC>CTT	p.L122L	GABRR1_uc011dzv.1_Silent_p.L99L	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	122	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GCCTCAGGTAGAGGGTCATCG	0.557			NA											45	165					0	0	0.013114	0	0
LYRM2	57226	broad.mit.edu	37	6	90348409	90348409	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:90348409C>A	uc003pnm.2	-	1	66	c.27G>T	c.(25-27)GCG>GCT	p.A9A	LYRM2_uc010kce.1_5'Flank|LYRM2_uc003png.2_RNA|LYRM2_uc010kcf.1_5'Flank|LYRM2_uc010kcg.2_5'Flank|LYRM2_uc003pnl.3_5'Flank	NM_020466	NP_065199	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	9											0		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		ACGTTAGCGTCGCTGGGGGTA	0.637			NA											29	139					4.31634e-10	4.86317e-10	0.012213	1	0
MAP3K7	6885	broad.mit.edu	37	6	91281451	91281451	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:91281451C>G	uc003pnz.1	-	2	358	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	MAP3K7_uc003poa.1_Missense_Mutation_p.E66Q|MAP3K7_uc003pob.1_Missense_Mutation_p.E66Q|MAP3K7_uc003poc.1_Missense_Mutation_p.E66Q	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	66	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GATTCACTTTCTATTTGTTTA	0.318			NA											8	57					0	0	0.008291	0	0
SIM1	6492	broad.mit.edu	37	6	100838702	100838702	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:100838702G>T	uc003pqj.3	-	11	2043	c.1836C>A	c.(1834-1836)CCC>CCA	p.P612P	SIM1_uc010kcu.2_Silent_p.P612P	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	612	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTGTTGGTGGGGGCTGTTGGT	0.498			NA											37	62					2.42023e-17	2.88783e-17	0.003271	1	0
SIM1	6492	broad.mit.edu	37	6	100841691	100841691	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:100841691C>T	uc003pqj.3	-	10	1449	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	SIM1_uc010kcu.2_Silent_p.T414T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	414	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GCGGAGAGGCCGTGTCGGTCA	0.577			NA											18	36					0	0	0.006122	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111896952	111896952	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:111896952C>G	uc011ebc.1	-	5	1710	c.1095G>C	c.(1093-1095)CTG>CTC	p.L365L	TRAF3IP2_uc003pvd.2_5'Flank|TRAF3IP2_uc003pvg.2_Silent_p.L365L|TRAF3IP2_uc003pvf.2_Silent_p.L365L|TRAF3IP2_uc010kdw.2_Silent_p.L365L|TRAF3IP2_uc010kdx.2_Silent_p.L365L	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	374					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CCTGTGGTCTCAGCTCTGCAG	0.547			NA											10	54					0	0	0.010729	0	0
ROS1	6098	broad.mit.edu	37	6	117632184	117632184	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:117632184T>A	uc003pxp.1	-	39	6431	c.6232A>T	c.(6232-6234)AGG>TGG	p.R2078W	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2078	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GAATTGTACCTGTGAATGAAA	0.383			NA	T	GOPC|ROS1	glioblastoma|NSCLC								31	42					0	0	0.010818	0	0
MYB	4602	broad.mit.edu	37	6	135511330	135511330	+	Silent	SNP	G	G	T	rs139729764		TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:135511330G>T	uc003qfc.2	+	5	571	c.372G>T	c.(370-372)GGG>GGT	p.G124G	MYB_uc003qfh.2_Silent_p.G124G|MYB_uc003qfi.2_Silent_p.G124G|MYB_uc010kgi.2_Silent_p.G124G|MYB_uc003qfq.2_Silent_p.G124G|MYB_uc010kgj.2_Silent_p.G124G|MYB_uc003qfo.2_Silent_p.G124G|MYB_uc003qfu.2_Silent_p.G124G|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Intron|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Intron|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Silent_p.G124G|MYB_uc003qgd.1_5'UTR	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	124	HTH myb-type 2.|Interaction with HIPK2 and NLK (By similarity).|H-T-H motif (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ACTTAAAGGGGAGAATTGGAA	0.398			NA	T	NFIB	adenoid cystic carcinoma								7	92					5.18039e-06	5.5821e-06	0.00308	1	0
MAP3K5	4217	broad.mit.edu	37	6	136977581	136977581	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:136977581A>G	uc003qhc.2	-	10	1905	c.1544T>C	c.(1543-1545)GTA>GCA	p.V515A	MAP3K5_uc011edj.1_5'UTR|MAP3K5_uc011edk.1_Missense_Mutation_p.V360A|MAP3K5_uc010kgw.1_Missense_Mutation_p.V515A	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	515					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		AATTGTCTCTACAATAGACTT	0.383			NA											35	98					0	0	0.013726	0	0
HECA	51696	broad.mit.edu	37	6	139488428	139488428	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:139488428G>A	uc003qin.2	+	2	1564	c.1279G>A	c.(1279-1281)GAG>AAG	p.E427K		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	427					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		GAGACATGATGAGATCGAATA	0.463			NA											16	57					0	0	0.003163	0	0
GRM1	2911	broad.mit.edu	37	6	146755353	146755353	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:146755353C>A	uc010khw.1	+	9	3476	c.3006C>A	c.(3004-3006)CTC>CTA	p.L1002L	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1002	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGACCCCCCTCTTCCTGGCCG	0.687			NA											50	79					3.19069e-20	3.84844e-20	0.01441	1	0
NUP43	348995	broad.mit.edu	37	6	150048227	150048227	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:150048227C>G	uc003qmz.2	-	8	1078	c.1021G>C	c.(1021-1023)GAA>CAA	p.E341Q	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Missense_Mutation_p.E245Q	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	341					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CTTGTGATTTCAATTCGGTCT	0.418			NA											10	68					0	0	0.008291	0	0
C6orf97	80129	broad.mit.edu	37	6	151907150	151907150	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:151907150C>G	uc003qol.2	+	7	1308	c.1219C>G	c.(1219-1221)CAG>GAG	p.Q407E		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	407	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TCTTCAGGGTCAGCTGACACA	0.483			NA											10	40					0	0	0.001855	0	0
SYNE1	23345	broad.mit.edu	37	6	152668219	152668219	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:152668219G>A	uc010kiw.2	-	73	12655	c.12053C>T	c.(12052-12054)TCA>TTA	p.S4018L	SYNE1_uc003qot.3_Missense_Mutation_p.S3947L|SYNE1_uc003qou.3_Missense_Mutation_p.S4018L|SYNE1_uc010kja.1_Missense_Mutation_p.S723L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4018	Spectrin 10.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCAGATCGCTGAGTAGCTGTC	0.488			NA								HNSCC(10;0.0054)			8	52					0	0	0.00308	0	0
SYNE1	23345	broad.mit.edu	37	6	152763354	152763354	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:152763354C>G	uc010kiw.2	-	31	4466	c.3864G>C	c.(3862-3864)AAG>AAC	p.K1288N	SYNE1_uc003qot.3_Missense_Mutation_p.K1295N|SYNE1_uc003qou.3_Missense_Mutation_p.K1288N|SYNE1_uc010kjb.1_Missense_Mutation_p.K1271N|SYNE1_uc003qow.2_Missense_Mutation_p.K583N|SYNE1_uc003qox.1_Missense_Mutation_p.K804N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1288	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CATCTCTCTTCTTTGCTGAGA	0.532			NA								HNSCC(10;0.0054)			11	76					0	0	0.010729	0	0
FBXO5	26271	broad.mit.edu	37	6	153296150	153296150	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:153296150C>G	uc003qpg.2	-	2	819	c.710G>C	c.(709-711)AGA>ACA	p.R237T	FBXO5_uc003qph.2_Missense_Mutation_p.R191T	NM_012177	NP_036309	Q9UKT4	FBX5_HUMAN	F-box only protein 5 isoform a	237	Interaction with EVI5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		GCCCATTTTTCTGCCAATTAT	0.383	NSCLC(121;372 1757 17721 17977 29669)		NA											7	102					0	0	0.00308	0	0
TULP4	56995	broad.mit.edu	37	6	158914615	158914615	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:158914615G>C	uc003qrf.2	+	10	2999	c.1642G>C	c.(1642-1644)GAG>CAG	p.E548Q	TULP4_uc003qrg.2_Missense_Mutation_p.E548Q	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	548					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GATCAGCATTGAGGCCCGCAA	0.657			NA											12	70					0	0	0.010729	0	0
SLC22A3	6581	broad.mit.edu	37	6	160819028	160819028	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:160819028C>G	uc003qti.2	+	2	474	c.447C>G	c.(445-447)GTC>GTG	p.V149V	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	149						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		TTGTCTGTGTCAATGCGTGGA	0.443			NA											22	139					0	0	0.003954	0	0
PACRG	135138	broad.mit.edu	37	6	163235198	163235198	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:163235198C>A	uc003qua.2	+	3	400	c.176C>A	c.(175-177)GCA>GAA	p.A59E	PACRG_uc003qub.2_Missense_Mutation_p.A59E|PACRG_uc003quc.2_Missense_Mutation_p.A59E	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	59											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		CCTCCAGCTGCAGGGGCATTT	0.378			NA											27	93					4.22769e-11	4.83683e-11	0.00632	1	0
FRMD1	79981	broad.mit.edu	37	6	168468049	168468049	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:168468049C>G	uc003qwo.3	-	3	447	c.382G>C	c.(382-384)GAA>CAA	p.E128Q	FRMD1_uc003qwm.3_5'Flank|FRMD1_uc011egs.1_5'UTR|FRMD1_uc011egt.1_Missense_Mutation_p.E40Q|FRMD1_uc003qwn.3_Missense_Mutation_p.E60Q	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	128	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		ACACTTACTTCATTTCTTTCT	0.512	GBM(50;8 1094 9538 34399)|Ovarian(80;676 1857 8675 49015)		NA											8	47					0	0	0.00308	0	0
SMOC2	64094	broad.mit.edu	37	6	168927058	168927058	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr6:168927058A>T	uc003qws.1	+	3	309	c.289A>T	c.(289-291)ACC>TCC	p.T97S	SMOC2_uc003qwr.1_Missense_Mutation_p.T97S	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	97	Thyroglobulin type-1 1.				signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		AAGGAAGTATACCCAGGAGCA	0.512			NA											25	55					0	0	0.010818	0	0
SDK1	221935	broad.mit.edu	37	7	4277383	4277383	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:4277383G>T	uc003smx.2	+	42	6236	c.6097G>T	c.(6097-6099)GGG>TGG	p.G2033W	SDK1_uc010kso.2_Missense_Mutation_p.G1289W|SDK1_uc003smy.2_Missense_Mutation_p.G520W|SDK1_uc003smz.2_Missense_Mutation_p.G93W	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2033	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGTCCTGCACGGGCAGAATAA	0.572			NA											41	36					3.4345e-17	4.09073e-17	0.011902	1	0
RBAK	57786	broad.mit.edu	37	7	5103989	5103989	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:5103989A>G	uc010kss.1	+	6	1226	c.902A>G	c.(901-903)AAG>AGG	p.K301R	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.K301R	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	301	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TTCAGCCAAAAGGGAACCCTC	0.408			NA											25	28					0	0	0.00333	0	0
DPY19L1	23333	broad.mit.edu	37	7	34971311	34971311	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:34971311A>G	uc003tem.3	-	22	2047	c.1902T>C	c.(1900-1902)GAT>GAC	p.D634D	DPY19L1_uc003tel.1_RNA	NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	634						integral to membrane					0						GATCTTCTACATCCCAAATTT	0.398			NA											3	36					0	0	0.004672	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882650	47882650	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:47882650G>C	uc003tny.1	-	34	5355	c.5355C>G	c.(5353-5355)ATC>ATG	p.I1785M		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1785	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CTTGCAGAAAGATGTAACCAG	0.448			NA											12	39					0	0	0.013537	0	0
POM121L12	285877	broad.mit.edu	37	7	53103733	53103733	+	Silent	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:53103733G>T	uc003tpz.2	+	1	385	c.369G>T	c.(367-369)GGG>GGT	p.G123G		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	123											0						TGAAAGGGGGGCTGTGTCGTG	0.697			NA											9	31					2.17888e-05	2.32158e-05	0.006214	1	0
ZNF479	90827	broad.mit.edu	37	7	57187738	57187738	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:57187738C>A	uc010kzo.2	-	5	1655	c.1384G>T	c.(1384-1386)GAG>TAG	p.E462*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TAGGGTCTCTCTCCAGTATGA	0.423			NA											47	88					1.67211e-32	2.09642e-32	0.01441	1	0
ZNF92	168374	broad.mit.edu	37	7	64864225	64864225	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:64864225G>T	uc003ttz.2	+	4	1341	c.1198G>T	c.(1198-1200)GAA>TAA	p.E400*	ZNF92_uc003tua.2_Nonsense_Mutation_p.E331*|ZNF92_uc010kzu.2_Nonsense_Mutation_p.E368*|ZNF92_uc003tub.2_Nonsense_Mutation_p.E324*	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	400	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CTACAAATGTGAAGAATGTGG	0.383			NA											7	38					0.00198382	0.00205467	0.001984	1	0
TRIM50	135892	broad.mit.edu	37	7	72738498	72738498	+	Silent	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:72738498G>C	uc010lbd.1	-	2	413	c.288C>G	c.(286-288)CTC>CTG	p.L96L	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Silent_p.L96L|TRIM50_uc003txz.1_Silent_p.L96L	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	96	B box-type.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						AGAAAAGGCTGAGCGGGTTCC	0.667			NA									OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	71					0	0	0.00499	0	0
SEMA3A	10371	broad.mit.edu	37	7	83640603	83640603	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:83640603C>A	uc003uhz.2	-	8	1136	c.821G>T	c.(820-822)GGA>GTA	p.G274V		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	274	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTGTGCCCTCCAAAGTCATT	0.378			NA											6	23					3.59834e-05	3.82789e-05	0.001168	1	0
AGFG2	3268	broad.mit.edu	37	7	100151083	100151083	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:100151083C>T	uc003uvf.2	+	4	681	c.545C>T	c.(544-546)CCT>CTT	p.P182L	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Silent_p.L44L	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	182					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						CTGGGTGATCCTGCACCGTCT	0.557			NA											13	76					0	0	0.013537	0	0
PRKRIP1	79706	broad.mit.edu	37	7	102036862	102036862	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:102036862G>A	uc003uzh.2	+	1	59	c.4G>A	c.(4-6)GCT>ACT	p.A2T	PRKRIP1_uc003uzf.2_Intron|PRKRIP1_uc003uzg.2_Intron|PRKRIP1_uc011kkq.1_Intron|PRKRIP1_uc011kkr.1_Missense_Mutation_p.A2T	NM_024653	NP_078929	Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	2	Interaction with EIF2AK2 (By similarity).					nucleolus				ovary(1)	1						GGCTGCCATGGCTAGCCCAGC	0.667			NA											8	4					0	0	0.00308	0	0
RELN	5649	broad.mit.edu	37	7	103341380	103341380	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:103341380G>A	uc003vca.2	-	9	1039	c.879C>T	c.(877-879)GAC>GAT	p.D293D	RELN_uc010liz.2_Silent_p.D293D	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	293					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCTGAATCCAGTCCGCAGAGT	0.363	NSCLC(146;835 1944 15585 22231 52158)		NA											40	61					0	0	0.009718	0	0
AHCYL2	23382	broad.mit.edu	37	7	129046264	129046264	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:129046264G>C	uc011kov.1	+	10	1306	c.1252G>C	c.(1252-1254)GTG>CTG	p.V418L	AHCYL2_uc003vot.2_Missense_Mutation_p.V417L|AHCYL2_uc003vov.2_Missense_Mutation_p.V315L|AHCYL2_uc011kow.1_Missense_Mutation_p.V316L|AHCYL2_uc011kox.1_Missense_Mutation_p.V315L	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	418					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GGGCTCCATTGTGTATGTAAC	0.502	Pancreas(160;1736 1964 29875 40941 45605)		NA											16	80					0	0	0.007413	0	0
FAM40B	57464	broad.mit.edu	37	7	129091575	129091575	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:129091575C>G	uc011koy.1	+	4	436	c.396C>G	c.(394-396)CTC>CTG	p.L132L	FAM40B_uc003vow.2_Silent_p.L132L	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	132											0						GGGCTGTTCTCTACCTGGCCC	0.567			NA											9	26					0	0	0.004482	0	0
MEST	4232	broad.mit.edu	37	7	130140669	130140669	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:130140669G>C	uc003vqg.2	+	9	904	c.687G>C	c.(685-687)GAG>GAC	p.E229D	MEST_uc003vqc.2_Missense_Mutation_p.E220D|MEST_uc003vqd.2_Intron|MEST_uc003vqf.2_Missense_Mutation_p.E220D|MEST_uc011kph.1_Missense_Mutation_p.E215D|MEST_uc010lmg.2_Missense_Mutation_p.E229D	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	229					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					GGCCCTCTGAGAGTGAGCTGT	0.463	Colon(126;2182 2305 6517 35181)		NA											3	38					0	0	0.009096	0	0
AKR1B10	57016	broad.mit.edu	37	7	134222405	134222405	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:134222405G>A	uc003vrr.2	+	7	1053	c.733G>A	c.(733-735)GCA>ACA	p.A245T		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	245					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						CAAAAAAACCGCAGCCCAGGT	0.448			NA											14	60					0	0	0.003163	0	0
NUP205	23165	broad.mit.edu	37	7	135304260	135304260	+	Silent	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:135304260C>G	uc003vsw.2	+	29	4084	c.4053C>G	c.(4051-4053)CTC>CTG	p.L1351L	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1351					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AGGCCGTCCTCACTGAACAGA	0.512			NA											25	35					0	0	0.003954	0	0
BRAF	673	broad.mit.edu	37	7	140482954	140482954	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:140482954G>C	uc003vwc.3	-	10	1242	c.1181C>G	c.(1180-1182)TCA>TGA	p.S394*		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	394					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	ACCTGTGGTTGATCCTAAATT	0.408	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				7	33					0	0	0.00308	0	0
PRSS1	5644	broad.mit.edu	37	7	142460304	142460304	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:142460304G>T	uc003wak.2	+	4	494	c.477G>T	c.(475-477)CAG>CAT	p.Q159H	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.Q99H	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	159	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ACGAGCTGCAGTGCCTGGATG	0.522			NA							Hereditary_Pancreatitis				14	262					3.32936e-07	3.64046e-07	0.006122	1	0
CASP2	835	broad.mit.edu	37	7	142988758	142988758	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:142988758C>T	uc003wco.2	+	2	347	c.200C>T	c.(199-201)ACC>ATC	p.T67I	CASP2_uc003wcp.2_Missense_Mutation_p.T67I|CASP2_uc011kta.1_5'UTR|CASP2_uc003wcq.2_RNA	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	67	CARD.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					GACATCATCACCTTGGAAATG	0.438			NA											21	124					0	0	0.012319	0	0
OR2A12	346525	broad.mit.edu	37	7	143792833	143792833	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:143792833C>T	uc011kty.1	+	1	633	c.633C>T	c.(631-633)TGC>TGT	p.C211C		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					GGCCGCTCTGCCTGGTGCTGG	0.562			NA											60	120					0	0	0.01441	0	0
ZNF786	136051	broad.mit.edu	37	7	148768612	148768612	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:148768612C>T	uc003wfh.2	-	4	1389	c.1252G>A	c.(1252-1254)GCG>ACG	p.A418T	ZNF786_uc011kuk.1_Missense_Mutation_p.A381T|ZNF786_uc003wfi.2_Missense_Mutation_p.A332T	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	418	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCACCGTGCGCGTGCTGGTGG	0.632			NA											4	24					0	0	0.000602	0	0
KCNH2	3757	broad.mit.edu	37	7	150648011	150648011	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:150648011C>G	uc003wic.2	-	8	2156	c.2143G>C	c.(2143-2145)GCG>CCG	p.A715P	KCNH2_uc003wib.2_Missense_Mutation_p.A375P|KCNH2_uc011kux.1_Missense_Mutation_p.A619P|KCNH2_uc003wid.2_Missense_Mutation_p.A375P|KCNH2_uc003wie.2_Missense_Mutation_p.A715P	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	715	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GGCCTCACCGCGTTCATGTCG	0.632	GBM(137;110 1844 13671 20123 45161)		NA											11	27					0	0	0.004007	0	0
NOS3	4846	broad.mit.edu	37	7	150696133	150696133	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:150696133C>A	uc003wif.2	+	8	1212	c.916C>A	c.(916-918)CCC>ACC	p.P306T	NOS3_uc011kuy.1_Missense_Mutation_p.P100T|NOS3_uc011kuz.1_Missense_Mutation_p.P306T|NOS3_uc011kva.1_Missense_Mutation_p.P306T|NOS3_uc011kvb.1_Missense_Mutation_p.P306T	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	306	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTTCCTTCTGCCCCCCGAGCT	0.642			NA											66	83					1.37693e-34	1.73613e-34	0.01441	1	0
SLC4A2	6522	broad.mit.edu	37	7	150764008	150764008	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr7:150764008G>C	uc003wit.3	+	7	1150	c.894G>C	c.(892-894)CAG>CAC	p.Q298H	SLC4A2_uc011kve.1_Missense_Mutation_p.Q289H|SLC4A2_uc003wiu.3_Missense_Mutation_p.Q284H	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	298	Cytoplasmic (Potential).|Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTTCCACACAGAGTGGCCGAG	0.657			NA											12	26					0	0	0.001855	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1881965	1881965	+	Splice_Site	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:1881965G>C	uc003wpr.2	+	26	3258	c.3080_splice	c.e26-1	p.D1027_splice	ARHGEF10_uc003wps.2_Splice_Site_p.D989_splice|ARHGEF10_uc010lre.2_Splice_Site_p.D678_splice	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10						centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TTTCTTTTAAGATGGATCCTG	0.418			NA											21	73					0	0	0.00333	0	0
RP1L1	94137	broad.mit.edu	37	8	10465806	10465806	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:10465806C>T	uc003wtc.2	-	4	6031	c.5802G>A	c.(5800-5802)GAG>GAA	p.E1934E		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1934					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CACCTTCTGACTCTGGCTCGT	0.602			NA											46	121					0	0	0.01441	0	0
CYP7B1	9420	broad.mit.edu	37	8	65528839	65528839	+	Splice_Site	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:65528839C>T	uc003xvj.2	-	3	464	c.260_splice	c.e3-1	p.G87_splice		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,						bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				ATGTACTTTCCTAGAAAAAAA	0.264			NA											3	12					0	0	0.001168	0	0
CSPP1	79848	broad.mit.edu	37	8	68007596	68007596	+	Silent	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:68007596A>T	uc003xxi.2	+	8	715	c.684A>T	c.(682-684)ACA>ACT	p.T228T	CSPP1_uc003xxg.1_Silent_p.T220T|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Silent_p.T193T|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	228						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAATACAGACATCTTGTGAAA	0.363			NA											13	69					0	0	0.001855	0	0
SULF1	23213	broad.mit.edu	37	8	70550826	70550826	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:70550826G>C	uc010lza.1	+	20	3091	c.2374G>C	c.(2374-2376)GAG>CAG	p.E792Q	SULF1_uc003xyd.2_Missense_Mutation_p.E792Q|SULF1_uc003xye.2_Missense_Mutation_p.E792Q|SULF1_uc003xyf.2_Missense_Mutation_p.E792Q|SULF1_uc003xyg.2_Missense_Mutation_p.E792Q|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_Intron|SULF1_uc003xyj.1_5'UTR	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	792					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TCTTTTCTGTGAGTTTGCTAC	0.353			NA											13	62					0	0	0.013537	0	0
IL7	3574	broad.mit.edu	37	8	79652305	79652305	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:79652305C>G	uc003ybg.2	-	3	761	c.160G>C	c.(160-162)GAA>CAA	p.E54Q	IL7_uc003ybe.2_Missense_Mutation_p.E13Q|IL7_uc011lfm.1_RNA|IL7_uc003ybh.2_RNA|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	54					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						CTACCAATTTCTTTCATGCTG	0.224			NA											9	36					0	0	0.006214	0	0
MMP16	4325	broad.mit.edu	37	8	89198707	89198707	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:89198707G>T	uc003yeb.3	-	3	684	c.402C>A	c.(400-402)TAC>TAA	p.Y134*	MMP16_uc003yec.2_Nonsense_Mutation_p.Y134*	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	134	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TCTTATACCTGTAAGTGATGT	0.403			NA											69	139					3.89499e-28	4.84693e-28	0.01441	1	0
DECR1	1666	broad.mit.edu	37	8	91013744	91013744	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:91013744C>G	uc003yek.1	+	1	165	c.24C>G	c.(22-24)TTC>TTG	p.F8L	DECR1_uc011lgc.1_5'UTR|DECR1_uc011lgd.1_RNA	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	8					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CCAGGGTTTTCTTTACTCTGG	0.667			NA									OREG0018857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	31					0	0	0.004672	0	0
PGCP	10404	broad.mit.edu	37	8	98041644	98041644	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:98041644G>A	uc003yhw.2	+	6	1141	c.975G>A	c.(973-975)AAG>AAA	p.K325K		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	325					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TGCGTCCAAAGAGGACTCTGC	0.428			NA											4	11					0	0	0.009096	0	0
LRP12	29967	broad.mit.edu	37	8	105510107	105510107	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:105510107G>A	uc003yma.2	-	5	768	c.673C>T	c.(673-675)CGT>TGT	p.R225C	LRP12_uc003ymb.2_Missense_Mutation_p.R206C|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	225	Extracellular (Potential).|LDL-receptor class A 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTGGTAAAACGGGATAAACAC	0.448			NA											45	96					0	0	0.01441	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464993	110464993	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:110464993C>G	uc003yne.2	+	43	6658	c.6554C>G	c.(6553-6555)TCA>TGA	p.S2185*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2185	Extracellular (Potential).|G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCCAATTTCTCATGGGGGGGA	0.388			NA								HNSCC(38;0.096)			2	9					0	0	0.004672	0	0
TRPS1	7227	broad.mit.edu	37	8	116632009	116632009	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:116632009T>G	uc003ynz.2	-	2	736	c.277A>C	c.(277-279)AAG>CAG	p.K93Q	TRPS1_uc011lhy.1_Missense_Mutation_p.K97Q|TRPS1_uc003yny.2_Missense_Mutation_p.K106Q|TRPS1_uc010mcy.2_Missense_Mutation_p.K93Q	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	93					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTCCTCCCTTACTGGGGCTT	0.473			NA							Langer-Giedion_syndrome				11	75					0	0	0.010729	0	0
FER1L6	654463	broad.mit.edu	37	8	125052198	125052198	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:125052198C>G	uc003yqw.2	+	20	2746	c.2540C>G	c.(2539-2541)TCA>TGA	p.S847*	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	847	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AATGGACTTTCAGACCCTTTT	0.522			NA											6	86					0	0	0.001168	0	0
TG	7038	broad.mit.edu	37	8	134030239	134030239	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:134030239C>T	uc003ytw.2	+	38	6820	c.6779C>T	c.(6778-6780)CCA>CTA	p.P2260L	TG_uc010mdw.2_Missense_Mutation_p.P1019L|TG_uc011ljb.1_Missense_Mutation_p.P629L|TG_uc011ljc.1_Missense_Mutation_p.P393L	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2260					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCCAGCAAGCCAAGGTATGGG	0.532			NA											15	20					0	0	0.00245	0	0
SPATC1	375686	broad.mit.edu	37	8	145095676	145095676	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr8:145095676C>G	uc011lkw.1	+	3	1076	c.974C>G	c.(973-975)TCC>TGC	p.S325C	SPATC1_uc011lkx.1_Missense_Mutation_p.S325C	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	325										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			gtccccacctcccccaccacc	0.378			NA											5	6					0	0	0.000602	0	0
KIAA2026	158358	broad.mit.edu	37	9	5988524	5988524	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:5988524C>T	uc003zjq.3	-	2	831	c.615G>A	c.(613-615)ACG>ACA	p.T205T		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	205										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAACTGCTATCGTTGTCTTTT	0.443			NA											4	20					0	0	0.000602	0	0
KDM4C	23081	broad.mit.edu	37	9	6986486	6986486	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:6986486A>T	uc003zkh.2	+	11	2077	c.1497A>T	c.(1495-1497)AAA>AAT	p.K499N	KDM4C_uc010mhu.2_Missense_Mutation_p.K521N|KDM4C_uc011lmi.1_Missense_Mutation_p.K499N|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.K499N|KDM4C_uc011lmk.1_Missense_Mutation_p.K318N|KDM4C_uc011lml.1_Missense_Mutation_p.K186N	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	499					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						AGCCCGAGAAATCAGACCCAT	0.463			NA											10	59					0	0	0.008291	0	0
PTPRD	5789	broad.mit.edu	37	9	8436648	8436648	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:8436648C>T	uc003zkk.2	-	34	4741	c.4030G>A	c.(4030-4032)GAC>AAC	p.D1344N	PTPRD_uc003zkp.2_Missense_Mutation_p.D938N|PTPRD_uc003zkq.2_Missense_Mutation_p.D937N|PTPRD_uc003zkr.2_Missense_Mutation_p.D928N|PTPRD_uc003zks.2_Missense_Mutation_p.D937N|PTPRD_uc003zkl.2_Missense_Mutation_p.D1335N|PTPRD_uc003zkm.2_Missense_Mutation_p.D1331N|PTPRD_uc003zkn.2_Missense_Mutation_p.D933N|PTPRD_uc003zko.2_Missense_Mutation_p.D934N	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1344	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAATGTGGTCTGCAAGTTCC	0.338			NA								TSP Lung(15;0.13)			10	48					0	0	0.010729	0	0
FREM1	158326	broad.mit.edu	37	9	14740193	14740193	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:14740193G>T	uc003zlm.2	-	36	6884	c.6294C>A	c.(6292-6294)CAC>CAA	p.H2098Q	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.H634Q	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2098	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GCCACCGCATGTGCTGCCTGG	0.473			NA											36	49					2.26627e-22	2.76345e-22	0.007835	1	0
TAF1L	138474	broad.mit.edu	37	9	32632473	32632473	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:32632473C>T	uc003zrg.1	-	1	3195	c.3105G>A	c.(3103-3105)GAG>GAA	p.E1035E	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1035					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ACTTTTTAATCTCTTCCTCAG	0.483			NA											40	203					0	0	0.007835	0	0
FAM166B	730112	broad.mit.edu	37	9	35563186	35563186	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:35563186G>C	uc010mkr.2	-	2	334	c.263C>G	c.(262-264)TCC>TGC	p.S88C	FAM166B_uc011lov.1_Missense_Mutation_p.S88C|FAM166B_uc011low.1_Missense_Mutation_p.S88C|FAM166B_uc003zwy.2_Missense_Mutation_p.S88C	NM_001164310	NP_001157782	A8MTA8	F166B_HUMAN	hypothetical protein LOC730112 isoform 1	88											0						GATCATGCTGGAGCTGAGCCT	0.577			NA											17	96					0	0	0.004007	0	0
CCIN	881	broad.mit.edu	37	9	36170550	36170550	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:36170550G>T	uc003zzb.3	+	1	1162	c.1051G>T	c.(1051-1053)GAT>TAT	p.D351Y		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	351	Kelch 2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GTATGACATGGATGACAACTC	0.572			NA											16	67					6.31663e-08	6.96395e-08	0.003163	1	0
FXN	2395	broad.mit.edu	37	9	71687670	71687670	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:71687670G>C	uc004aha.2	+	5	845	c.625G>C	c.(625-627)GAT>CAT	p.D209H	FXN_uc011lrr.1_Intron|FXN_uc004agz.2_3'UTR	NM_000144	NP_000135	Q16595	FRDA_HUMAN	frataxin isoform 1 preproprotein	209					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding				0						TTCCGGAAAAGATGCTTGATG	0.473			NA											15	62					0	0	0.003163	0	0
PHF2	5253	broad.mit.edu	37	9	96439907	96439907	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:96439907G>A	uc004aub.2	+	22	3387	c.3240G>A	c.(3238-3240)CAG>CAA	p.Q1080Q	PHF2_uc004auc.2_Intron	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	1080					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CCGCCAAGCAGAGGCTTGGGA	0.537			NA											36	121					0	0	0.003755	0	0
ZNF483	158399	broad.mit.edu	37	9	114304757	114304757	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:114304757G>C	uc004bff.2	+	6	1766	c.1542G>C	c.(1540-1542)CAG>CAC	p.Q514H	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	514	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						TTAAACATCAGAGAATTCATA	0.408			NA											16	55					0	0	0.004007	0	0
CCBL1	883	broad.mit.edu	37	9	131600361	131600361	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:131600361C>A	uc004bwh.2	-	5	592	c.407G>T	c.(406-408)GGG>GTG	p.G136V	CCBL1_uc004bwf.2_Missense_Mutation_p.G170V|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.G136V|CCBL1_uc004bwj.2_Missense_Mutation_p.G86V|CCBL1_uc011mbl.1_Missense_Mutation_p.G230V|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.G136V	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	136					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	AGGACGACCCCCTGCCATCAT	0.547			NA											68	117					1.7488e-33	2.1967e-33	0.01441	1	0
BARHL1	56751	broad.mit.edu	37	9	135464746	135464746	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:135464746G>A	uc004cbp.1	+	3	1013	c.821G>A	c.(820-822)GGC>GAC	p.G274D		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	274						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		CTGGACCCCGGCGCGGCGCTC	0.672			NA											23	55					0	0	0.014323	0	0
PMPCA	23203	broad.mit.edu	37	9	139311650	139311650	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr9:139311650C>T	uc004chl.2	+	7	886	c.881C>T	c.(880-882)ACT>ATT	p.T294I	PMPCA_uc010nbl.2_Missense_Mutation_p.T194I|PMPCA_uc011mdz.1_Missense_Mutation_p.T163I|PMPCA_uc004chm.1_Missense_Mutation_p.T44I|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	294					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GCCCAGTACACTGGGGGGATT	0.612			NA											11	23					0	0	0.008291	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734961	12734961	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:12734961G>T	uc004cuz.1	+	15	2889	c.2383G>T	c.(2383-2385)GAG>TAG	p.E795*	FRMPD4_uc011mij.1_Nonsense_Mutation_p.E787*	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	795					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGATGACAATGAGGATGACTT	0.562			NA											36	123					1.30015e-28	1.62093e-28	0.004878	1	0
TCEANC	170082	broad.mit.edu	37	X	13681425	13681425	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:13681425G>A	uc004cvk.2	+	2	1028	c.798G>A	c.(796-798)CTG>CTA	p.L266L	TCEANC_uc010nee.1_Silent_p.L266L|TCEANC_uc010nef.1_Silent_p.L266L|TCEANC_uc010neg.1_Silent_p.L296L|TCEANC_uc004cvl.2_RNA	NM_152634	NP_689847	Q8N8B7	TEANC_HUMAN	TFIIS central domain-containing protein 1	266	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1						ATAAGGAACTGAAGCAGTTGA	0.428			NA											4	10					0	0	0.009096	0	0
FANCB	2187	broad.mit.edu	37	X	14883041	14883041	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:14883041G>C	uc004cwg.1	-	3	860	c.592C>G	c.(592-594)CAA>GAA	p.Q198E	FANCB_uc004cwh.1_Missense_Mutation_p.Q198E	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	198					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					GAAGGCTCTTGAGTACATTCT	0.333			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				29	131					0	0	0.008361	0	0
PIGA	5277	broad.mit.edu	37	X	15339736	15339736	+	Silent	SNP	A	A	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:15339736A>G	uc004cwr.2	-	6	1447	c.1347T>C	c.(1345-1347)TCT>TCC	p.S449S	PIGA_uc010neu.2_Silent_p.S65S|PIGA_uc004cwq.2_Silent_p.S134S|PIGA_uc010nev.2_Silent_p.S280S|PIGA_uc004cws.2_Silent_p.S134S|PIGA_uc011miq.1_Silent_p.S215S	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	449	Lumenal (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					CATCAATGATAGAATCTGGAG	0.428			NA											27	102					0	0	0.010818	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20187547	20187547	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:20187547C>G	uc004czu.2	-	16	1416	c.1416G>C	c.(1414-1416)CAG>CAC	p.Q472H	RPS6KA3_uc011mjk.1_Missense_Mutation_p.Q442H|RPS6KA3_uc004czv.2_Missense_Mutation_p.Q459H|RPS6KA3_uc011mjl.1_Missense_Mutation_p.Q443H|RPS6KA3_uc011mjm.1_Missense_Mutation_p.Q444H	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	472	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TGTTTGGATGCTGTCCATAAC	0.308			NA											24	104					0	0	0.005443	0	0
KLHL34	257240	broad.mit.edu	37	X	21674331	21674331	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:21674331C>A	uc004czz.1	-	1	2118	c.1576G>T	c.(1576-1578)GGC>TGC	p.G526C		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	526	Kelch 4.									ovary(1)	1						AACACAGCGCCGCGCAGCACT	0.647			NA											3	5					6.4e-05	6.78665e-05	0.004672	1	0
YY2	404281	broad.mit.edu	37	X	21875591	21875591	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:21875591C>G	uc011mjp.1	+	1	989	c.989C>G	c.(988-990)ACA>AGA	p.T330R	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.T548R|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	330	Mediates transcriptional repression.|C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AATTTGCGCACACACTTGCGC	0.527			NA											54	263					0	0	0.01441	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212565	26212565	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:26212565C>A	uc004dbr.2	+	2	751	c.602C>A	c.(601-603)ACG>AAG	p.T201K	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	201	MAGE.									ovary(3)	3						AAGGCGTGCACGTTGGCGCAA	0.483			NA											39	100					1.49673e-21	1.81513e-21	0.00623	1	0
FAM47A	158724	broad.mit.edu	37	X	34148133	34148133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:34148133G>A	uc004ddg.2	-	1	2296	c.2263C>T	c.(2263-2265)CAA>TAA	p.Q755*		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	755										ovary(4)|central_nervous_system(1)	5						AACAGCCTTTGAATGATGCCA	0.408			NA											25	104					0	0	0.008361	0	0
FAM47C	442444	broad.mit.edu	37	X	37028224	37028224	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:37028224C>A	uc004ddl.1	+	1	1755	c.1741C>A	c.(1741-1743)CAT>AAT	p.H581N		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	581										ovary(3)	3						TGGAGTGTCCCATCTCTGCCC	0.657			NA											57	115					3.00063e-23	3.69265e-23	0.01441	1	0
OTC	5009	broad.mit.edu	37	X	38262962	38262962	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:38262962T>A	uc004def.3	+	6	846	c.632T>A	c.(631-633)TTC>TAC	p.F211Y		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	211					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	GCAGCGAAATTCGGAATGCAC	0.473			NA											16	55					0	0	0.003163	0	0
USP11	8237	broad.mit.edu	37	X	47100188	47100188	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:47100188G>A	uc004dhp.2	+	7	888	c.888G>A	c.(886-888)TCG>TCA	p.S296S	USP11_uc004dhq.2_Silent_p.S23S	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	296					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						ACAACATGTCGGAAGAGGATG	0.532			NA											6	28					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	X	48164277	48164277	+	Silent	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:48164277G>A	uc010nib.1	-	2	93	c.6C>T	c.(4-6)AAC>AAT	p.N2N		NM_174962	NP_777622			synovial sarcoma, X breakpoint 9												NA						CATCGTCTCCGTTCATGGCAC	0.552			NA											50	181					0	0	0.01441	0	0
IQSEC2	23096	broad.mit.edu	37	X	53284025	53284025	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:53284025A>T	uc004dsd.2	-	4	1289	c.1088T>A	c.(1087-1089)ATG>AAG	p.M363K	IQSEC2_uc004dsc.2_Missense_Mutation_p.M158K	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	353	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GTTCTTGTTCATGCGGTACTG	0.587			NA											5	19					0	0	0.001984	0	0
FAM123B	139285	broad.mit.edu	37	X	63411898	63411898	+	Silent	SNP	C	C	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:63411898C>A	uc004dvo.2	-	2	1542	c.1269G>T	c.(1267-1269)CTG>CTT	p.L423L		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	423					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GATGGTAGCCCAGGTTCATAT	0.428			NA											22	57					1.39806e-14	1.64463e-14	0.008361	1	0
ZC4H2	55906	broad.mit.edu	37	X	64137684	64137684	+	Silent	SNP	C	C	T	rs149235340	byFrequency	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:64137684C>T	uc004dvu.2	-	5	742	c.654G>A	c.(652-654)CCG>CCA	p.P218P	ZC4H2_uc004dvv.2_Silent_p.P195P|ZC4H2_uc011mov.1_Silent_p.P195P|ZC4H2_uc011mow.1_Missense_Mutation_p.R164Q|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	218							metal ion binding|protein binding			ovary(1)	1						GCTTCCGTTTCGGCTTTTTGG	0.488			NA											4	20					0	0	0.009096	0	0
RPS4X	6191	broad.mit.edu	37	X	71496038	71496038	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:71496038T>C	uc004ear.2	-	2	146	c.50A>G	c.(49-51)CAT>CGT	p.H17R	RPS4X_uc011mqb.1_Missense_Mutation_p.H17R	NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	17					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					CAGCATCCAATGCTTTGGAGC	0.428			NA											3	36					0	0	0.000602	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913593	77913593	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:77913593G>T	uc004edc.1	-	2	621	c.325C>A	c.(325-327)CCA>ACA	p.P109T		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	109	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						GGGGCTGCTGGGGCCTCCTGG	0.642			NA											11	12					2.80697e-09	3.13086e-09	0.010729	1	0
RPA4	29935	broad.mit.edu	37	X	96139888	96139888	+	Silent	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:96139888C>T	uc004efv.3	+	1	877	c.579C>T	c.(577-579)AAC>AAT	p.N193N	DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efu.3_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	replication protein A4, 34kDa	193					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding				0						CTGGGGATAACGATGAGAGTC	0.502			NA						Other_identified_genes_with_known_or_suspected_DNA_repair_function					23	64					0	0	0.00333	0	0
MORF4L2	9643	broad.mit.edu	37	X	102931253	102931253	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:102931253T>A	uc004ekw.2	-	4	1935	c.703A>T	c.(703-705)ATT>TTT	p.I235F	MORF4L2_uc004ela.2_Missense_Mutation_p.I235F|MORF4L2_uc004ekx.2_Missense_Mutation_p.I235F|MORF4L2_uc004elb.2_Missense_Mutation_p.I235F|MORF4L2_uc004eky.2_Missense_Mutation_p.I235F|MORF4L2_uc010nos.2_Missense_Mutation_p.I235F|MORF4L2_uc004ekz.2_Missense_Mutation_p.I235F|MORF4L2_uc011mry.1_Missense_Mutation_p.I235F|MORF4L2_uc011mrz.1_Missense_Mutation_p.I235F|MORF4L2_uc004elc.2_Missense_Mutation_p.I235F|MORF4L2_uc004elf.2_Missense_Mutation_p.I235F|MORF4L2_uc004ele.2_Missense_Mutation_p.I235F|MORF4L2_uc011msa.1_Missense_Mutation_p.I235F|MORF4L2_uc011msb.1_Missense_Mutation_p.I235F|MORF4L2_uc011msc.1_Missense_Mutation_p.I235F|MORF4L2_uc011msd.1_Missense_Mutation_p.I235F|MORF4L2_uc004eld.2_Missense_Mutation_p.I235F	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	235					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						ATTGCTCCAATTCTTACAAAT	0.438			NA											8	42					0	0	0.00308	0	0
COL4A5	1287	broad.mit.edu	37	X	107909764	107909764	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:107909764G>A	uc004enz.1	+	39	3695	c.3493G>A	c.(3493-3495)GAA>AAA	p.E1165K	COL4A5_uc011mso.1_Missense_Mutation_p.E1165K	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1165	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GCCTCCAGGCGAAAAAGGCAA	0.458			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				3	18					0	0	0.009096	0	0
STAG2	10735	broad.mit.edu	37	X	123190075	123190075	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:123190075C>G	uc004etz.3	+	13	1633	c.1294C>G	c.(1294-1296)CTC>GTC	p.L432V	STAG2_uc004eua.2_Missense_Mutation_p.L432V|STAG2_uc004eub.2_Missense_Mutation_p.L432V|STAG2_uc004euc.2_Missense_Mutation_p.L432V|STAG2_uc004eud.2_Missense_Mutation_p.L432V|STAG2_uc004eue.2_Missense_Mutation_p.L432V	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	432					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGGAGAATTTCTCTACAAAAA	0.328			NA											19	40					0	0	0.008871	0	0
GPR112	139378	broad.mit.edu	37	X	135429886	135429886	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:135429886C>T	uc004ezu.1	+	6	4312	c.4021C>T	c.(4021-4023)CCA>TCA	p.P1341S	GPR112_uc010nsb.1_Missense_Mutation_p.P1136S|GPR112_uc010nsc.1_Missense_Mutation_p.P1108S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1341	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAGATTACACCAACCTTGAC	0.473			NA											38	45					0	0	0.005524	0	0
AFF2	2334	broad.mit.edu	37	X	148037480	148037480	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:148037480G>C	uc004fcp.2	+	11	2384	c.1905G>C	c.(1903-1905)GAG>GAC	p.E635D	AFF2_uc004fcq.2_Missense_Mutation_p.E625D|AFF2_uc004fcr.2_Missense_Mutation_p.E596D|AFF2_uc011mxb.1_Missense_Mutation_p.E600D|AFF2_uc004fcs.2_Missense_Mutation_p.E602D|AFF2_uc011mxc.1_Missense_Mutation_p.E276D	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	635					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAAAAGTTGAGAAGAACACCA	0.423			NA											34	96					0	0	0.012213	0	0
MAGEA4	4103	broad.mit.edu	37	X	151093032	151093032	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:151093032G>A	uc004fez.2	+	3	1052	c.896G>A	c.(895-897)CGC>CAC	p.R299H	MAGEA4_uc004ffa.2_Missense_Mutation_p.R299H|MAGEA4_uc004ffb.2_Missense_Mutation_p.R299H|MAGEA4_uc004ffc.2_Missense_Mutation_p.R299H|MAGEA4_uc004ffd.2_Missense_Mutation_p.R299H	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCAAGAGTTCGCATTGCCTAC	0.572			NA											43	103					0	0	0.009718	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482539	152482539	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:152482539C>G	uc004fhf.2	-	3	692	c.472G>C	c.(472-474)GAC>CAC	p.D158H		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	158	MAGE.					cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCTTCACGTCAATGCCAAAG	0.502			NA											38	105					0	0	0.005524	0	0
TPRG1L	127262	broad.mit.edu	37	1	3544203	3544204	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:3544203_3544204insC	uc001akm.2	+	4	691_692	c.610_611insC	c.(610-612)GCAfs	p.A204fs	TPRG1L_uc009vlj.2_Frame_Shift_Ins_p.A145fs	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	204						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		TGAGAAGACAGCATCTCTGTGT	0.545			NA											23	97	---	---	---	---	NA	NA	NA	NA	NA
EYA3	2140	broad.mit.edu	37	1	28330898	28330898	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:28330898delG	uc001bpi.1	-	11	1107	c.942delC	c.(940-942)ATCfs	p.I314fs	EYA3_uc010ofs.1_Frame_Shift_Del_p.I261fs|EYA3_uc010oft.1_Frame_Shift_Del_p.I268fs|EYA3_uc001bpj.2_Frame_Shift_Del_p.I268fs|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	314					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		GGAAGATGATGATGGTTTCAT	0.279			NA											16	84	---	---	---	---	NA	NA	NA	NA	NA
JUN	3725	broad.mit.edu	37	1	59247894	59247894	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:59247894delT	uc001cze.2	-	1	1892	c.849delA	c.(847-849)AAAfs	p.K283fs	uc001czf.2_5'Flank|uc010oop.1_5'Flank	NM_002228	NP_002219	P05412	JUN_HUMAN	jun oncogene	283	Leucine-zipper.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding				0	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	AGGTTTTCACTTTTTCCTCCA	0.547			NA	A		sarcoma						OREG0013518	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	75	---	---	---	---	NA	NA	NA	NA	NA
C1orf116	79098	broad.mit.edu	37	1	207198231	207198231	+	Splice_Site	DEL	C	C	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:207198231delC	uc001hfd.2	-	3	542	c.283_splice	c.e3+1	p.G95_splice	C1orf116_uc009xcb.1_Splice_Site	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform							cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					GTCTGCCTTACCCCGGGGAGT	0.602			NA											35	105	---	---	---	---	NA	NA	NA	NA	NA
HIST3H3	8290	broad.mit.edu	37	1	228612837	228612837	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr1:228612837delG	uc001hsx.1	-	1	190	c.190delC	c.(190-192)CGCfs	p.R64fs		NM_003493	NP_003484	Q16695	H31T_HUMAN	histone cluster 3, H3	64					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		Prostate(94;0.0724)				GGCAACTTGCGGATTAGCAGC	0.657			NA											8	183	---	---	---	---	NA	NA	NA	NA	NA
RGR	5995	broad.mit.edu	37	10	86017689	86017689	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr10:86017689delG	uc001kdc.1	+	6	709	c.671delG	c.(670-672)TGGfs	p.W224fs	RGR_uc001kdd.1_Frame_Shift_Del_p.W228fs|RGR_uc001kde.1_Intron	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	224	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CTGCTCGGCTGGGGCCCCTAT	0.537	NSCLC(15;204 545 5889 6385 32445)		NA											12	61	---	---	---	---	NA	NA	NA	NA	NA
ATM	472	broad.mit.edu	37	11	108143265	108143265	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr11:108143265delA	uc001pkb.1	+	21	3469	c.3084delA	c.(3082-3084)CTAfs	p.L1028fs	ATM_uc009yxr.1_Frame_Shift_Del_p.L1028fs	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1028					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TCAGGCATCTAACAAAGGAGA	0.313			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			59	33	---	---	---	---	NA	NA	NA	NA	NA
MYH7	4625	broad.mit.edu	37	14	23889251	23889251	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:23889251delC	uc001wjx.2	-	27	3635	c.3529delG	c.(3529-3531)GACfs	p.D1177fs	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1177	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCCAGGTCCCGCCGCATC	0.682			NA											9	3	---	---	---	---	NA	NA	NA	NA	NA
SERPINA1	5265	broad.mit.edu	37	14	94849053	94849053	+	Frame_Shift_Del	DEL	G	G	-	rs72552402	byFrequency	TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr14:94849053delG	uc001ycx.3	-	2	783	c.522delC	c.(520-522)ACCfs	p.T174fs	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc010aux.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc001ycy.3_Frame_Shift_Del_p.T174fs|SERPINA1_uc010auy.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc001ycz.3_Frame_Shift_Del_p.T174fs|SERPINA1_uc010auz.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc010ava.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc001ydb.3_Frame_Shift_Del_p.T174fs|SERPINA1_uc010avb.2_Frame_Shift_Del_p.T174fs|SERPINA1_uc001ydc.3_Frame_Shift_Del_p.T174fs|SERPINA1_uc001yda.1_Frame_Shift_Del_p.T174fs	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	174				T -> H (in Ref. 4; AAA51546).	acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TGGCCTCTTCGGTGTCCCCGA	0.473			NA							Alpha-1-Antitrypsin_Deficiency				89	46	---	---	---	---	NA	NA	NA	NA	NA
ULK2	9706	broad.mit.edu	37	17	19705093	19705107	+	In_Frame_Del	DEL	AAGGGGAAGGTGAGT	AAGGGGAAGGTGAGT	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	AAGGGGAAGGTGAGT	AAGGGGAAGGTGAGT	-	-	AAGGGGAAGGTGAGT	AAGGGGAAGGTGAGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr17:19705093_19705107delAAGGGGAAGGTGAGT	uc002gwm.3	-	16	1933_1947	c.1424_1438delACTCACCTTCCCCTT	c.(1423-1440)TACTCACCTTCCCCTTTG>TTG	p.YSPSP475del	ULK2_uc002gwn.2_In_Frame_Del_p.YSPSP475del	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	475_479					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TACTTACCCAAAGGGGAAGGTGAGTAAGGCCTAGA	0.479			NA											41	103	---	---	---	---	NA	NA	NA	NA	NA
REXO1	57455	broad.mit.edu	37	19	1827408	1827409	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chr19:1827408_1827409insA	uc002lua.3	-	2	1474_1475	c.1379_1380insT	c.(1378-1380)CCCfs	p.P460fs	REXO1_uc010dsr.1_Frame_Shift_Ins_p.P414fs	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	460						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCGCTTGTGGGGCTCGGCCG	0.723			NA											4	4	---	---	---	---	NA	NA	NA	NA	NA
GPR112	139378	broad.mit.edu	37	X	135432460	135432460	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7539-01A-11D-2063-08	TCGA-78-7539-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda8bdf1-626a-417c-8c57-998b4a79872e	7385c065-1d06-4525-b66b-cdcecedcb6b9	g.chrX:135432460delG	uc004ezu.1	+	6	6886	c.6595delG	c.(6595-6597)GGGfs	p.G2199fs	GPR112_uc010nsb.1_Frame_Shift_Del_p.G1994fs|GPR112_uc010nsc.1_Frame_Shift_Del_p.G1966fs	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2199	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATATCCACTGGGGTGACATA	0.428			NA											60	58	---	---	---	---	NA	NA	NA	NA	NA
