Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL21	9903	broad.mit.edu	37	1	6655584	6655584	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:6655584C>A	uc001aoa.2	-	3	1513	c.1461G>T	c.(1459-1461)CCG>CCT	p.P487P	KLHL21_uc001anz.1_Silent_p.P487P|KLHL21_uc009vme.2_Silent_p.P120P	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	487	Kelch 5.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		CGTTCCTCGTCGGGTTGTACA	0.567			NA											11	33					2.32078e-09	3.56353e-09	0.003163	1	0
SLC45A1	50651	broad.mit.edu	37	1	8390292	8390292	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:8390292G>A	uc001apb.2	+	4	739	c.739G>A	c.(739-741)GTG>ATG	p.V247M	SLC45A1_uc001apc.2_Translation_Start_Site	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	247	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTTTGGATACGTGGTCGGCGG	0.607			NA											5	75					0	0	0.000602	0	0
LOC440563	440563	broad.mit.edu	37	1	13183710	13183710	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:13183710C>T	uc010obg.1	-	1	258	c.163G>A	c.(163-165)GTT>ATT	p.V55I		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	55						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TCATATTGAACGAAGGCAAAG	0.473			NA											8	50					0	0	0.000673	0	0
SH2D5	400745	broad.mit.edu	37	1	21050589	21050589	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:21050589C>T	uc001bdt.1	-	6	1159	c.534G>A	c.(532-534)TCG>TCA	p.S178S	SH2D5_uc009vpy.1_Silent_p.S262S|SH2D5_uc001bdu.1_RNA	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	178											0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCTCCCGAGCCGACAGCTGCA	0.667			NA											6	28					0	0	0.001984	0	0
PHACTR4	65979	broad.mit.edu	37	1	28818172	28818172	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:28818172G>T	uc001bpw.2	+	12	2171	c.1889G>T	c.(1888-1890)AGG>ATG	p.R630M	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.R614M|PHACTR4_uc001bpy.2_Missense_Mutation_p.R640M|PHACTR4_uc001bpz.2_RNA	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	630	RPEL 3.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAGTCAAAGGCCAACTGTC	0.418			NA											35	82					1.836e-18	3.24884e-18	0.003755	1	0
Unknown	0	broad.mit.edu	37	1	33778171	33778171	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:33778171G>T	uc001bxd.1	-	3	128	c.128C>A	c.(127-129)CCC>CAC	p.P43H		NM_001080438	NP_001073907			RecName: Full=Alpha 1,3-galactosyltransferase 2;          Short=A3galt2;          EC=2.4.1.87; AltName: Full=Isoglobotriaosylceramide synthase; AltName: Full=iGb3 synthase;          Short=iGb3S; Flags: Precursor;												NA						GACGCCCATGGGGATGAGGGC	0.627			NA											5	77					8.12818e-05	0.000105711	0.001984	1	0
MACF1	23499	broad.mit.edu	37	1	39852909	39852909	+	Nonsense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:39852909C>T	uc010oiu.1	+	22	9846	c.9715C>T	c.(9715-9717)CAG>TAG	p.Q3239*	MACF1_uc010ois.1_Nonsense_Mutation_p.Q2737*|MACF1_uc001cda.1_Nonsense_Mutation_p.Q2624*|MACF1_uc001cdc.1_Nonsense_Mutation_p.Q1803*	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4804	Spectrin 4.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAGCAGTTCCAGCAAATGTT	0.443			NA											33	242					0	0	0.003755	0	0
ASB17	127247	broad.mit.edu	37	1	76387904	76387904	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:76387904A>G	uc001dhe.1	-	2	682	c.542T>C	c.(541-543)ATT>ACT	p.I181T	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	181					intracellular signal transduction					ovary(1)	1						TGTTAAGACAATGTTGATAGG	0.358			NA											15	48					0	0	0.00245	0	0
LPHN2	23266	broad.mit.edu	37	1	82456564	82456564	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:82456564A>T	uc001dit.3	+	21	4128	c.3947A>T	c.(3946-3948)TAT>TTT	p.Y1316F	LPHN2_uc001dis.2_Missense_Mutation_p.Y296F|LPHN2_uc001diu.2_Missense_Mutation_p.Y1316F|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.Y943F	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1372	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GACTCTCTTTATACAAGCATG	0.512			NA											7	91					0	0	0.001984	0	0
ZNF644	84146	broad.mit.edu	37	1	91403192	91403192	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:91403192T>A	uc001dnw.2	-	4	3680	c.3538A>T	c.(3538-3540)ATG>TTG	p.M1180L	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TCTTCTCCCATCCTTTTATTT	0.353			NA											19	95					0	0	0.007413	0	0
SASS6	163786	broad.mit.edu	37	1	100572478	100572478	+	Silent	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:100572478A>G	uc001dsu.2	-	12	1539	c.1398T>C	c.(1396-1398)AAT>AAC	p.N466N	SASS6_uc009wdz.2_Silent_p.N299N	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	466	Potential.				centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		ACTTTTCATTATTTTTTAGAA	0.204			NA											5	26					0	0	0.001168	0	0
ADORA3	140	broad.mit.edu	37	1	112028429	112028429	+	Silent	SNP	C	C	T	rs138501072		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:112028429C>T	uc001ebf.2	-	5	1673	c.906G>A	c.(904-906)ACG>ACA	p.T302T	ADORA3_uc001ebg.3_Silent_p.T221T	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	TTCCCAAACCCGTGATCAGTA	0.448			NA											13	57					0	0	0.004007	0	0
FAM19A3	284467	broad.mit.edu	37	1	113269262	113269262	+	Nonstop_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:113269262G>T	uc001ecv.2	+	5	471	c.402G>T	c.(400-402)TAG>TAT	p.*134Y	FAM19A3_uc001ecu.2_Missense_Mutation_p.S157I|FAM19A3_uc010owk.1_RNA|FAM19A3_uc010owl.1_RNA	NM_182759	NP_877436	Q7Z5A8	F19A3_HUMAN	family with sequence similarity 19 (chemokine	134						extracellular region					0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACACGATAGCTCTTGGGGG	0.502			NA											15	43					6.31663e-08	9.25143e-08	0.003163	1	0
ZNF697	90874	broad.mit.edu	37	1	120166700	120166700	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:120166700C>G	uc001ehy.1	-	3	380	c.266G>C	c.(265-267)GGG>GCG	p.G89A		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		ATCCTCTTCCCCACGGACAGA	0.547			NA											4	21					0	0	0.000602	0	0
THEM5	284486	broad.mit.edu	37	1	151820280	151820280	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:151820280G>A	uc009wnd.2	-	5	766	c.634C>T	c.(634-636)CAG>TAG	p.Q212*		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	212							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TAAAGCTTCTGGTCCTCAATC	0.567			NA											27	59					0	0	0.00361	0	0
HRNR	388697	broad.mit.edu	37	1	152188290	152188290	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:152188290G>A	uc001ezt.1	-	3	5891	c.5815C>T	c.(5815-5817)CAT>TAT	p.H1939Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1939	21.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGACCCATGTTGGCCGTGG	0.587			NA											8	610					0	0	0.00308	0	0
FLG	2312	broad.mit.edu	37	1	152279834	152279834	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:152279834A>T	uc001ezu.1	-	3	7564	c.7528T>A	c.(7528-7530)TCC>ACC	p.S2510T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2510	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCACTTCTGGATCCTGAGTGC	0.557			NA							Ichthyosis				15	674					0	0	0.003163	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154530853	154530853	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:154530853G>A	uc001fff.1	-	1	268	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	59							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGGCAATGCGGAAGCGCTCGT	0.423			NA											3	6					0	0	0.004672	0	0
CLK2	1196	broad.mit.edu	37	1	155237843	155237843	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:155237843T>C	uc001fjy.2	-	6	919	c.629A>G	c.(628-630)AAC>AGC	p.N210S	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Missense_Mutation_p.N209S|CLK2_uc001fjx.2_5'UTR|CLK2_uc009wqm.2_Missense_Mutation_p.N210S	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	210	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTCTAGCACGTTGATCTCAAG	0.498			NA						Other_conserved_DNA_damage_response_genes					85	125					0	0	0.00361	0	0
CD1D	912	broad.mit.edu	37	1	158152851	158152851	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:158152851G>T	uc001frr.2	+	5	1290	c.791G>T	c.(790-792)CGA>CTA	p.R264L	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	264	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					TGGTATCTCCGAGCAACCCTG	0.617			NA											49	95					4.86159e-25	9.29365e-25	0.00361	1	0
OR6K6	128371	broad.mit.edu	37	1	158725166	158725166	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:158725166G>T	uc001fsw.1	+	1	561	c.561G>T	c.(559-561)GAG>GAT	p.E187D		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	187	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TGCTTCCTGAGATTGCATGGA	0.483			NA											51	96					8.00217e-19	1.4266e-18	0.00361	1	0
IGSF8	93185	broad.mit.edu	37	1	160063849	160063849	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:160063849G>T	uc001fva.2	-	3	600	c.555C>A	c.(553-555)GGC>GGA	p.G185G	IGSF8_uc001fuz.2_Silent_p.G185G|IGSF8_uc009wtf.2_Silent_p.G185G	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	185	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCGCCAGGCAGCCCAGTGCCA	0.672			NA											5	75					0.000602214	0.000760356	0.000602	1	0
RGS4	5999	broad.mit.edu	37	1	163039313	163039313	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:163039313G>C	uc009wuy.2	+	1	550	c.39G>C	c.(37-39)TTG>TTC	p.L13F	RGS4_uc001gcl.3_Missense_Mutation_p.L110F|RGS4_uc009wuz.2_Missense_Mutation_p.L13F|RGS4_uc009wva.2_5'Flank	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	13					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						CTTCTTGCTTGAGGAGGTAAG	0.428	Ovarian(76;1257 1738 3039 6086)		NA									OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	62					0	0	0.000602	0	0
BAT2L2	23215	broad.mit.edu	37	1	171504670	171504670	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:171504670G>T	uc010pmg.1	+	13	2237	c.1971G>T	c.(1969-1971)CCG>CCT	p.P657P		NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	657							protein C-terminus binding				0						AACCTCGGCCGGCTGTATTAT	0.443			NA											61	189					2.81305e-35	5.67378e-35	0.00361	1	0
ASTN1	460	broad.mit.edu	37	1	176845701	176845701	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:176845701G>A	uc001glc.2	-	21	3647	c.3435C>T	c.(3433-3435)TGC>TGT	p.C1145C	ASTN1_uc001glb.1_Silent_p.C1145C|ASTN1_uc001gld.1_Silent_p.C1145C	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1153					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CCACCACGGGGCATGGGGTCT	0.577			NA											25	64					0	0	0.005443	0	0
ASTN1	460	broad.mit.edu	37	1	176927584	176927584	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:176927584G>T	uc001glc.2	-	10	1845	c.1633C>A	c.(1633-1635)CCC>ACC	p.P545T	ASTN1_uc001glb.1_Missense_Mutation_p.P545T|ASTN1_uc001gld.1_Missense_Mutation_p.P545T|ASTN1_uc009wwx.1_Missense_Mutation_p.P545T	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	553					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TTGCTGAGGGGCAACCACATG	0.557			NA											9	28					5.4927e-09	8.30008e-09	0.004482	1	0
FAM5C	339479	broad.mit.edu	37	1	190067324	190067324	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:190067324G>T	uc001gse.1	-	8	2357	c.2125C>A	c.(2125-2127)CGT>AGT	p.R709S	FAM5C_uc010pot.1_Missense_Mutation_p.R607S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	709						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTATTTACACGGTCTCTGATC	0.483			NA											31	76					8.16721e-17	1.41883e-16	0.002096	1	0
PKP1	5317	broad.mit.edu	37	1	201293709	201293709	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:201293709G>T	uc001gwd.2	+	11	2148	c.1897G>T	c.(1897-1899)GGG>TGG	p.G633W	PKP1_uc001gwe.2_Missense_Mutation_p.G612W|PKP1_uc009wzm.2_Missense_Mutation_p.G220W	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	633	ARM 8.				cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						CAGAGTGATGGGTAAGGTCCC	0.572			NA											11	21					4.68919e-08	6.93185e-08	0.000673	1	0
CR1	1378	broad.mit.edu	37	1	207758146	207758146	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:207758146C>A	uc001hfy.2	+	25	4245	c.4105C>A	c.(4105-4107)CGC>AGC	p.R1369S	CR1_uc009xcl.1_Missense_Mutation_p.R919S|CR1_uc001hfx.2_Missense_Mutation_p.R1819S	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1369	Extracellular (Potential).|Sushi 21.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GAGCACCATCCGCTGCACAAG	0.522			NA											13	212					0.000308642	0.000390728	0.003163	1	0
USH2A	7399	broad.mit.edu	37	1	216592004	216592004	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:216592004G>A	uc001hku.1	-	3	890	c.503C>T	c.(502-504)ACA>ATA	p.T168I	USH2A_uc001hkv.2_Missense_Mutation_p.T168I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	168	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCATCTACTGTCTTTTCTAT	0.383			NA								HNSCC(13;0.011)			8	107					0	0	0.00308	0	0
OBSCN	84033	broad.mit.edu	37	1	228557766	228557766	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:228557766C>T	uc009xez.1	+	91	20135	c.20091C>T	c.(20089-20091)TTC>TTT	p.F6697F	OBSCN_uc001hsr.1_Silent_p.F1326F	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6697	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCAAAGACTTCATCAAGGCTA	0.682			NA											5	77					0	0	0.001168	0	0
HEATR1	55127	broad.mit.edu	37	1	236761272	236761272	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:236761272C>A	uc001hyd.1	-	5	634	c.509G>T	c.(508-510)GGA>GTA	p.G170V		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	170					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TAACGGCACTCCAGATTGCTG	0.378			NA											26	54					1.04121e-07	1.51565e-07	0.005443	1	0
RYR2	6262	broad.mit.edu	37	1	237789031	237789031	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:237789031C>A	uc001hyl.1	+	40	6213	c.6093C>A	c.(6091-6093)TCC>TCA	p.S2031S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2031	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTCTGCTATCCCTGGTAGAAA	0.423			NA											26	81					1.42536e-11	2.27674e-11	0.004656	1	0
NLRP3	114548	broad.mit.edu	37	1	247592928	247592928	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:247592928T>G	uc001icr.2	+	6	2336	c.2198T>G	c.(2197-2199)CTC>CGC	p.L733R	NLRP3_uc001ics.2_Missense_Mutation_p.L733R|NLRP3_uc001icu.2_Missense_Mutation_p.L733R|NLRP3_uc001icw.2_Intron|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Missense_Mutation_p.L731R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	733					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGCCGGGGCCTCTTTTCAGTT	0.478			NA											4	186					0	0	0.000248	0	0
OR11L1	391189	broad.mit.edu	37	1	248005039	248005039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:248005039G>A	uc001idn.1	-	1	160	c.160C>T	c.(160-162)CGA>TGA	p.R54*		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGTGCAGTCGCAGGCCCTGG	0.537			NA											6	24					0	0	0.001168	0	0
OR2L3	391192	broad.mit.edu	37	1	248224863	248224863	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:248224863A>C	uc001idx.1	+	1	880	c.880A>C	c.(880-882)AAG>CAG	p.K294Q	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCTGAGGAACAAGGAGGTGAT	0.498			NA											27	79					0	0	0.00632	0	0
OR2M5	127059	broad.mit.edu	37	1	248308490	248308490	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:248308490T>C	uc010pze.1	+	1	41	c.41T>C	c.(40-42)CTC>CCC	p.L14P		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GACTTCATCCTCCTGGGAATC	0.438			NA											9	449					0	0	0.000673	0	0
C10orf18	54906	broad.mit.edu	37	10	5788306	5788306	+	Silent	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:5788306A>G	uc001iij.2	+	15	3547	c.2922A>G	c.(2920-2922)CAA>CAG	p.Q974Q	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	974										ovary(1)|central_nervous_system(1)	2						CTGTTACTCAAGCCACATTCA	0.463			NA											6	85					0	0	0.001168	0	0
CACNB2	783	broad.mit.edu	37	10	18795447	18795447	+	Missense_Mutation	SNP	G	G	C	rs149253719	by1000genomes	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:18795447G>C	uc001ipr.2	+	6	701	c.641G>C	c.(640-642)AGT>ACT	p.S214T	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Missense_Mutation_p.S214T|CACNB2_uc001ipt.2_Missense_Mutation_p.S214T|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.S186T|CACNB2_uc001ipv.2_Missense_Mutation_p.S186T|CACNB2_uc009xka.1_Missense_Mutation_p.S186T|CACNB2_uc001ipw.2_Missense_Mutation_p.S159T|CACNB2_uc001ipx.2_Missense_Mutation_p.S159T|CACNB2_uc009xkb.1_Missense_Mutation_p.S160T|CACNB2_uc010qcm.1_Missense_Mutation_p.S160T|CACNB2_uc001ipz.2_Missense_Mutation_p.S160T|CACNB2_uc001ipy.2_Missense_Mutation_p.S160T|CACNB2_uc010qcn.1_Missense_Mutation_p.S166T|CACNB2_uc010qco.1_Missense_Mutation_p.S166T|CACNB2_uc001iqa.2_Missense_Mutation_p.S166T	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	214					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATAGTACCTAGTTCCAGAAAA	0.373			NA											9	43					0	0	0.000673	0	0
CACNB2	783	broad.mit.edu	37	10	18795465	18795465	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:18795465C>A	uc001ipr.2	+	6	719	c.659C>A	c.(658-660)CCT>CAT	p.P220H	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Missense_Mutation_p.P220H|CACNB2_uc001ipt.2_Missense_Mutation_p.P220H|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.P192H|CACNB2_uc001ipv.2_Missense_Mutation_p.P192H|CACNB2_uc009xka.1_Missense_Mutation_p.P192H|CACNB2_uc001ipw.2_Missense_Mutation_p.P165H|CACNB2_uc001ipx.2_Missense_Mutation_p.P165H|CACNB2_uc009xkb.1_Missense_Mutation_p.P166H|CACNB2_uc010qcm.1_Missense_Mutation_p.P166H|CACNB2_uc001ipz.2_Missense_Mutation_p.P166H|CACNB2_uc001ipy.2_Missense_Mutation_p.P166H|CACNB2_uc010qcn.1_Missense_Mutation_p.P172H|CACNB2_uc010qco.1_Missense_Mutation_p.P172H|CACNB2_uc001iqa.2_Missense_Mutation_p.P172H	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	220					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAATCAACACCTCCATCATCT	0.363			NA											18	28					1.50039e-11	2.37271e-11	0.001882	1	0
ANKRD26	22852	broad.mit.edu	37	10	27375513	27375513	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:27375513T>G	uc001ith.2	-	5	836	c.664A>C	c.(664-666)AAA>CAA	p.K222Q	ANKRD26_uc009xku.1_Missense_Mutation_p.K222Q	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	222						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CTTTCTTCTTTATATTCTGAA	0.264			NA											36	121					0	0	0.006999	0	0
PPYR1	5540	broad.mit.edu	37	10	47087519	47087519	+	Missense_Mutation	SNP	C	C	A	rs151042454	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:47087519C>A	uc001jee.2	+	3	1155	c.736C>A	c.(736-738)CGC>AGC	p.R246S	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Missense_Mutation_p.R246S	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	246	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						GAGGCAGGGGCGCGTGTTTCA	0.592			NA											12	70					0.00010058	0.000130452	0.001368	1	0
DNA2	1763	broad.mit.edu	37	10	70202766	70202766	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:70202766G>A	uc001jof.2	-	9	1581	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	DNA2_uc001jog.1_Silent_p.F441F|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	441					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						ACCAAAGGCTGAAATATTCTA	0.398			NA											9	24					0	0	0.004482	0	0
HTR7	3363	broad.mit.edu	37	10	92616928	92616928	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:92616928C>A	uc001kha.2	-	1	744	c.501G>T	c.(499-501)ACG>ACT	p.T167T	HTR7_uc001kgz.2_Silent_p.T167T|HTR7_uc001khb.2_Silent_p.T167T	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	167	Helical; Name=3; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TGATCGAGGCCGTGCAGCACA	0.617			NA											17	7					5.3912e-06	7.26973e-06	0.006122	1	0
DNTT	1791	broad.mit.edu	37	10	98078206	98078206	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:98078206C>A	uc001kmf.2	+	2	471	c.301C>A	c.(301-303)CTC>ATC	p.L101I	DNTT_uc001kmg.2_Missense_Mutation_p.L101I	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	101	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		ACAACCAGAGCTCCTCGATGT	0.488			NA											39	116					2.19358e-23	4.12705e-23	0.005524	1	0
C10orf28	27291	broad.mit.edu	37	10	99969246	99969246	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:99969246A>G	uc001kow.3	+	4	1670	c.1375A>G	c.(1375-1377)ACA>GCA	p.T459A	C10orf28_uc001kox.3_Missense_Mutation_p.T459A|C10orf28_uc001koy.3_Missense_Mutation_p.T459A|C10orf28_uc009xvx.2_Missense_Mutation_p.T459A|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	459							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		TACAGAGTCAACAGGAAAGTT	0.378			NA											8	70					0	0	0.004482	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362429	105362429	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:105362429C>G	uc001kxj.1	-	14	2602	c.2462G>C	c.(2461-2463)AGC>ACC	p.S821T	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.S656T|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.S698T|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.S656T|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.S764T	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	849	SH3 4.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CTGGTAGGCGCTGCATGTCAT	0.612			NA											11	65					0	0	0.000978	0	0
SYCE1	93426	broad.mit.edu	37	10	135367822	135367822	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr10:135367822G>T	uc009ybn.2	-	13	1034	c.929C>A	c.(928-930)CCA>CAA	p.P310Q	CYP2E1_uc001lnl.1_Intron|SYCE1_uc001lnm.2_Missense_Mutation_p.P182Q|SYCE1_uc001lnn.2_Missense_Mutation_p.P274Q	NM_001143763	NP_001137235	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	311					cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TGGTCTACCTGGTCTGGGAGC	0.468			NA											25	71					1.5548e-18	2.76151e-18	0.005443	1	0
OR52E2	119678	broad.mit.edu	37	11	5080209	5080209	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:5080209G>C	uc010qyw.1	-	1	649	c.649C>G	c.(649-651)CTT>GTT	p.L217V		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		ACATAAGAAAGGGCAATGACT	0.408			NA											4	75					0	0	0.000602	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529784	5529784	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:5529784G>C	uc001may.1	-	2	1091	c.1005C>G	c.(1003-1005)AAC>AAG	p.N335K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	335										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACCCAGAAAGTTTGGAAACC	0.512	Ovarian(72;684 1260 12332 41642 52180)		NA											3	118					0	0	0.004672	0	0
OLFML1	283298	broad.mit.edu	37	11	7530834	7530834	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:7530834C>A	uc001mfi.2	+	3	976	c.624C>A	c.(622-624)ATC>ATA	p.I208I	OLFML1_uc010raz.1_Silent_p.I72I|OLFML1_uc010rba.1_Silent_p.I208I	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	208	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GGAAGCAAATCCTAACACTTT	0.403			NA											24	36					3.7963e-18	6.69274e-18	0.00333	1	0
USP47	55031	broad.mit.edu	37	11	11976665	11976665	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:11976665G>T	uc001mjs.2	+	27	4610	c.3847G>T	c.(3847-3849)GTC>TTC	p.V1283F	USP47_uc001mjr.2_Missense_Mutation_p.V1215F|USP47_uc009ygi.2_Missense_Mutation_p.V85F	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1303					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TACCCTGAATGTCTGGCCTCT	0.358			NA											46	101					2.56662e-36	5.19876e-36	0.003214	1	0
TPH1	7166	broad.mit.edu	37	11	18047172	18047172	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:18047172C>A	uc001mnp.2	-	7	906	c.880G>T	c.(880-882)GGC>TGC	p.G294C	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	294					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	GAAGCCAAGCCAATTTCTTGG	0.453			NA											42	83					3.43241e-23	6.40717e-23	0.002222	1	0
DCDC1	341019	broad.mit.edu	37	11	31329334	31329334	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:31329334C>G	uc001msv.2	-	4	488	c.286G>C	c.(286-288)GAT>CAT	p.D96H	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	96					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					GTGGAGCAATCTTGAAGTCCT	0.388			NA											5	279					0	0	0.001984	0	0
AMBRA1	55626	broad.mit.edu	37	11	46455071	46455071	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:46455071G>A	uc010rgu.1	-	14	3289	c.2929C>T	c.(2929-2931)CAG>TAG	p.Q977*	AMBRA1_uc010rgt.1_Nonsense_Mutation_p.Q543*|AMBRA1_uc009ylc.1_Nonsense_Mutation_p.Q948*|AMBRA1_uc001ncu.1_Nonsense_Mutation_p.Q887*|AMBRA1_uc001ncv.2_Nonsense_Mutation_p.Q980*|AMBRA1_uc001ncw.2_Nonsense_Mutation_p.Q858*|AMBRA1_uc001ncx.2_Nonsense_Mutation_p.Q917*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	977					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CTGAAGACCTGGGCCACCATG	0.582			NA											8	20					0	0	0.00308	0	0
MS4A14	84689	broad.mit.edu	37	11	60184410	60184410	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:60184410C>A	uc001npj.2	+	5	2534	c.1969C>A	c.(1969-1971)CAC>AAC	p.H657N	MS4A14_uc001npi.2_Missense_Mutation_p.H545N|MS4A14_uc001npn.2_Missense_Mutation_p.H395N|MS4A14_uc001npk.2_Missense_Mutation_p.H640N|MS4A14_uc001npl.2_Missense_Mutation_p.H395N|MS4A14_uc001npm.2_Missense_Mutation_p.H395N	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	657	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CTGGCAATTCCACAAAGGCAA	0.453			NA											34	85					1.62565e-12	2.62308e-12	0.002445	1	0
INTS5	80789	broad.mit.edu	37	11	62416483	62416483	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:62416483C>A	uc001nud.2	-	2	1122	c.1069G>T	c.(1069-1071)GGA>TGA	p.G357*	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	357					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						ACAAGCTCTCCAGAGACAGTG	0.602			NA											25	56					5.35047e-06	7.25591e-06	0.00333	1	0
ZBTB3	79842	broad.mit.edu	37	11	62519947	62519947	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:62519947A>T	uc001nuz.2	-	2	1462	c.1340T>A	c.(1339-1341)CTG>CAG	p.L447Q		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						TGGCTCATGCAGGGATGCGGG	0.552			NA											21	54					0	0	0.00278	0	0
NXF1	10482	broad.mit.edu	37	11	62568674	62568674	+	Splice_Site	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:62568674C>A	uc001nvf.1	-	9	935	c.799_splice	c.e9-1	p.L267_splice	NXF1_uc001nvg.1_Splice_Site_p.L267_splice|NXF1_uc009yog.1_Splice_Site_p.L310_splice|NXF1_uc010rmh.1_Splice_Site_p.L130_splice	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1						gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						AGGACAATAGCTGTGAGGAGA	0.493			NA											13	44					0.000151284	0.000194625	0.001855	1	0
NXF1	10482	broad.mit.edu	37	11	62571288	62571288	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:62571288G>A	uc001nvf.1	-	2	327	c.191C>T	c.(190-192)GCC>GTC	p.A64V	NXF1_uc001nvg.1_Missense_Mutation_p.A64V|NXF1_uc009yog.1_Missense_Mutation_p.A107V|NXF1_uc010rmh.1_Intron	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	64	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						ACCATCCTGGGCATCACTCAT	0.483			NA											16	153					0	0	0.007413	0	0
SART1	9092	broad.mit.edu	37	11	65743992	65743992	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:65743992C>G	uc001ogl.2	+	13	1791	c.1699C>G	c.(1699-1701)CCC>GCC	p.P567A		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	567					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						GGGGGAGATCCCCACCTACGG	0.697			NA											8	32					0	0	0.000978	0	0
SHANK2	22941	broad.mit.edu	37	11	70507767	70507767	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:70507767C>G	uc001oqc.2	-	13	1948	c.1870G>C	c.(1870-1872)GAG>CAG	p.E624Q	SHANK2_uc010rqn.1_Missense_Mutation_p.E36Q|SHANK2_uc001opz.2_Missense_Mutation_p.E36Q|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Missense_Mutation_p.E36Q	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	245					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCGTCTTCTCCTCAATAATG	0.547			NA											27	202					0	0	0.00632	0	0
LRRC32	2615	broad.mit.edu	37	11	76371671	76371671	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:76371671C>G	uc001oxq.3	-	3	1209	c.966G>C	c.(964-966)TTG>TTC	p.L322F	LRRC32_uc001oxr.3_Missense_Mutation_p.L322F|LRRC32_uc010rsf.1_Missense_Mutation_p.L322F	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	322	LRR 11.|Extracellular (Potential).					integral to plasma membrane					0						CATTGTAGCTCAAATCCAGAT	0.597			NA											22	45					0	0	0.002299	0	0
CADM1	23705	broad.mit.edu	37	11	115049441	115049441	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:115049441C>A	uc001ppi.3	-	9	1262	c.1133G>T	c.(1132-1134)GGT>GTT	p.G378V	CADM1_uc001ppf.3_Missense_Mutation_p.G350V|CADM1_uc001ppk.3_Missense_Mutation_p.G350V|CADM1_uc001ppj.3_Missense_Mutation_p.G379V|CADM1_uc001pph.3_Missense_Mutation_p.G141V	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	378	Helical; (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CACGACGCCACCGATCACGGC	0.512			NA											10	131					7.48243e-07	1.03536e-06	0.006214	1	0
ZNF202	7753	broad.mit.edu	37	11	123597329	123597329	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:123597329G>A	uc001pzd.1	-	9	1723	c.1323C>T	c.(1321-1323)GCC>GCT	p.A441A	ZNF202_uc001pzc.1_Silent_p.A217A|ZNF202_uc001pze.1_Silent_p.A441A|ZNF202_uc001pzf.1_Silent_p.A441A	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	441	C2H2-type 2.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TTTGGTGCCTGGCAAGATGTG	0.468			NA											47	96					0	0	0.00361	0	0
ROBO3	64221	broad.mit.edu	37	11	124740965	124740965	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:124740965C>A	uc001qbc.2	+	7	1281	c.1089C>A	c.(1087-1089)AGC>AGA	p.S363R		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	363	Ig-like C2-type 4.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTGGAGAGAGCGTGGCTTTCC	0.602			NA											22	46					1.22574e-08	1.83475e-08	0.002299	1	0
DCPS	28960	broad.mit.edu	37	11	126215396	126215396	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:126215396T>C	uc001qdp.2	+	6	1231	c.902T>C	c.(901-903)GTG>GCG	p.V301A	uc001qdq.1_Intron	NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme	301					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		CTGGCTGAGGTGATCGAGAAC	0.652			NA											19	108					0	0	0.001216	0	0
PRDM10	56980	broad.mit.edu	37	11	129784679	129784679	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:129784679G>T	uc001qfm.2	-	18	3005	c.2773C>A	c.(2773-2775)CAG>AAG	p.Q925K	PRDM10_uc001qfj.2_Missense_Mutation_p.Q839K|PRDM10_uc001qfk.2_Missense_Mutation_p.Q835K|PRDM10_uc001qfl.2_Missense_Mutation_p.Q839K|PRDM10_uc010sbx.1_Missense_Mutation_p.Q835K|PRDM10_uc001qfn.2_Missense_Mutation_p.Q921K|PRDM10_uc009zcs.1_Missense_Mutation_p.Q108K	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	925	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GGGATGTACTGAATTCTCTGG	0.562			NA											78	123					4.75426e-39	9.67105e-39	0.00361	1	0
ACAD8	27034	broad.mit.edu	37	11	134131719	134131719	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:134131719G>T	uc001qhk.2	+	9	1088	c.1027G>T	c.(1027-1029)GAG>TAG	p.E343*	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Nonsense_Mutation_p.E266*|ACAD8_uc001qhl.2_Nonsense_Mutation_p.E216*	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	343					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		TCTGCAGGAGGAGAGGAAGGA	0.567	GBM(65;238 1125 33403 41853 48889)		NA											16	31					2.62699e-14	4.37219e-14	0.003163	1	0
HSN2	378465	broad.mit.edu	37	12	977030	977030	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:977030A>G	uc001qiq.2	+	1	161	c.35A>G	c.(34-36)CAG>CGG	p.Q12R	WNK1_uc001qio.3_Intron|WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_213655	NP_998820			hereditary sensory neuropathy, type II												0	all_cancers(10;0.0107)|all_epithelial(11;0.0151)|Ovarian(42;0.0512)|all_lung(10;0.0521)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.000967)|BRCA - Breast invasive adenocarcinoma(9;0.0178)			ATGTTGATACAGCCTCAGTCC	0.413			NA											14	30					0	0	0.00245	0	0
SPSB2	84727	broad.mit.edu	37	12	6981812	6981812	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:6981812G>T	uc001qrl.2	-	2	410	c.254C>A	c.(253-255)TCA>TAA	p.S85*	SPSB2_uc001qrm.2_Nonsense_Mutation_p.S85*|SPSB2_uc010sfp.1_Nonsense_Mutation_p.S85*|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	85	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						CAGGCCCCTTGAATAGCCCCT	0.662			NA									OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	31					1.10513e-12	1.78926e-12	0.002299	1	0
A2M	2	broad.mit.edu	37	12	9231857	9231857	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:9231857C>A	uc001qvk.1	-	25	3215	c.3102G>T	c.(3100-3102)AGG>AGT	p.R1034S	A2M_uc001qvj.1_Missense_Mutation_p.R76S|A2M_uc009zgk.1_Missense_Mutation_p.R884S	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1034					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TGCCCTGGTTCCTGCCATATC	0.303			NA											20	61					5.26018e-13	8.57481e-13	0.001882	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21471751	21471751	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:21471751G>C	uc001rer.2	-	2	418	c.167C>G	c.(166-168)TCT>TGT	p.S56C	SLCO1A2_uc001res.2_Missense_Mutation_p.S56C|SLCO1A2_uc010siq.1_Translation_Start_Site|SLCO1A2_uc010sio.1_Translation_Start_Site|SLCO1A2_uc010sip.1_Intron|SLCO1A2_uc001ret.2_Missense_Mutation_p.S54C|SLCO1A2_uc001reu.2_Missense_Mutation_p.S36C	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	56	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCCAACTAGAGATGTTGGGAT	0.338			NA											37	90					0	0	0.00623	0	0
ABCC9	10060	broad.mit.edu	37	12	22068791	22068791	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:22068791C>G	uc001rfi.1	-	5	647	c.627G>C	c.(625-627)CAG>CAC	p.Q209H	ABCC9_uc001rfh.2_Missense_Mutation_p.Q209H|ABCC9_uc001rfj.1_Missense_Mutation_p.Q209H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	209	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTCCCAGATCCTGGAGGTCTT	0.363			NA											28	57					0	0	0.007291	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			15	16					8.60227e-14	1.42176e-13	0.004007	1	0
ANO6	196527	broad.mit.edu	37	12	45781954	45781954	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:45781954T>A	uc001roo.2	+	11	1511	c.1176T>A	c.(1174-1176)TTT>TTA	p.F392L	ANO6_uc010sld.1_Missense_Mutation_p.F392L|ANO6_uc010sle.1_Missense_Mutation_p.F392L|ANO6_uc010slf.1_Missense_Mutation_p.F413L|ANO6_uc010slg.1_Missense_Mutation_p.F374L	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	392	Helical; (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						TTACCTTGTTTTTGGAGTTTT	0.393			NA											7	136					0	0	0.004482	0	0
KRT6B	3854	broad.mit.edu	37	12	52843583	52843583	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:52843583G>C	uc001sak.2	-	4	919	c.871C>G	c.(871-873)CTT>GTT	p.L291V		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	291	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCATCTGTAAGAGTGTCTGCC	0.498			NA											6	148					0	0	0.001984	0	0
TARBP2	6895	broad.mit.edu	37	12	53899014	53899014	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:53899014G>A	uc001sdo.2	+	7	1197	c.709G>A	c.(709-711)GAG>AAG	p.E237K	TARBP2_uc001sdp.2_Missense_Mutation_p.E216K|TARBP2_uc001sdq.2_Missense_Mutation_p.E93K|TARBP2_uc001sdr.2_Missense_Mutation_p.E93K|TARBP2_uc001sds.2_Intron|TARBP2_uc001sdt.2_Missense_Mutation_p.E216K|TARBP2_uc001sdu.2_Missense_Mutation_p.E93K|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	237	Sufficient for interaction with DICER1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						GGATGGCAATGAGGTGGAGCC	0.602			NA											6	86					0	0	0.001984	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57867885	57867885	+	Silent	SNP	G	G	T	rs61758883	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:57867885G>T	uc001sod.2	-	19	2321	c.2128C>A	c.(2128-2130)CGG>AGG	p.R710R	ARHGAP9_uc001sny.2_Intron|ARHGAP9_uc001snz.2_Silent_p.R436R|ARHGAP9_uc001soa.2_Silent_p.R309R|ARHGAP9_uc001sob.2_Silent_p.R620R|ARHGAP9_uc001soc.2_Silent_p.R620R|ARHGAP9_uc001soe.1_Silent_p.R699R	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	639	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			GGCAGCTCCCGGAGAAAAAGC	0.572			NA											5	42					1.23904e-05	1.63375e-05	0.000602	1	0
KIF5A	3798	broad.mit.edu	37	12	57972080	57972080	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:57972080C>A	uc001sor.1	+	23	2701	c.2493C>A	c.(2491-2493)TCC>TCA	p.S831S	KIF5A_uc010srr.1_Silent_p.S742S	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	831					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						AGAAGATTTCCTTTCTTGAGA	0.483			NA											49	105					2.74695e-27	5.31524e-27	0.00361	1	0
KCNC2	3747	broad.mit.edu	37	12	75444758	75444758	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:75444758C>A	uc001sxg.1	-	3	1571	c.1027G>T	c.(1027-1029)GTG>TTG	p.V343L	KCNC2_uc009zry.2_Missense_Mutation_p.V343L|KCNC2_uc001sxe.2_Missense_Mutation_p.V343L|KCNC2_uc001sxf.2_Missense_Mutation_p.V343L|KCNC2_uc010stw.1_Missense_Mutation_p.V343L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	343					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AAGCCAAGCACATCTTTAGCA	0.458			NA											16	53					1.01871e-10	1.59509e-10	0.001216	1	0
TBX5	6910	broad.mit.edu	37	12	114793673	114793673	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:114793673G>T	uc001tvo.2	-	9	1716	c.1221C>A	c.(1219-1221)TAC>TAA	p.Y407*	TBX5_uc001tvp.2_Nonsense_Mutation_p.Y407*|TBX5_uc001tvq.2_Nonsense_Mutation_p.Y357*	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	407					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TGCAGCTGCTGTAGGAAGGCA	0.647	NSCLC(152;1358 1980 4050 23898 40356)		NA											18	52					3.32936e-07	4.67485e-07	0.006122	1	0
ORAI1	84876	broad.mit.edu	37	12	122079355	122079355	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:122079355G>A	uc010szz.1	+	3	905	c.712G>A	c.(712-714)GCC>ACC	p.A238T		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	238	Helical; (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		AGCTGCCATCGCCTCGACCAC	0.642			NA											9	62					0	0	0.004482	0	0
IL31	386653	broad.mit.edu	37	12	122657105	122657105	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:122657105G>A	uc001ubv.2	-	3	376	c.349C>T	c.(349-351)CAA>TAA	p.Q117*	LRRC43_uc001ubw.3_Intron|LRRC43_uc009zxl.1_Intron	NM_001014336	NP_001014358	Q6EBC2	IL31_HUMAN	interleukin 31 precursor	117						extracellular space	cytokine activity			central_nervous_system(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GGTGCATCTTGAAATATGAGT	0.433			NA											18	116					0	0	0.007413	0	0
ABCB9	23457	broad.mit.edu	37	12	123419912	123419912	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:123419912G>A	uc001udm.3	-	10	2120	c.1810C>T	c.(1810-1812)CTG>TTG	p.L604L	ABCB9_uc010tai.1_Silent_p.L211L|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Silent_p.L561L|ABCB9_uc010taj.1_Silent_p.L541L|ABCB9_uc001udp.2_Silent_p.L604L|ABCB9_uc001udq.2_Silent_p.L323L	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	604	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ACAGTGGGCAGGCCGTAGGAG	0.617	Ovarian(49;786 1333 9175 38236)		NA											4	63					0	0	0.000602	0	0
CHFR	55743	broad.mit.edu	37	12	133438086	133438086	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:133438086C>A	uc001ulf.2	-	7	838	c.754G>T	c.(754-756)GAT>TAT	p.D252Y	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.D240Y|CHFR_uc010tbs.1_Missense_Mutation_p.D252Y|CHFR_uc001uld.2_Missense_Mutation_p.D211Y|CHFR_uc010tbt.1_Missense_Mutation_p.D160Y	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	252					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GGCTCCAAATCCTCCTGATCC	0.567			NA											41	105					9.39024e-22	1.71914e-21	0.002222	1	0
TUBA3C	7278	broad.mit.edu	37	13	19751729	19751729	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:19751729G>T	uc009zzj.2	-	4	443	c.394C>A	c.(394-396)CTG>ATG	p.L132M		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	132					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		AAGCCCTGCAGTCCCGTGCAC	0.582			NA											15	52					1.49906e-05	1.96571e-05	0.00245	1	0
SHISA2	387914	broad.mit.edu	37	13	26620766	26620766	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:26620766G>A	uc001uqm.1	-	2	858	c.773C>T	c.(772-774)CCC>CTC	p.P258L		NM_001007538	NP_001007539	Q6UWI4	SHSA2_HUMAN	shisa homolog 2 precursor	258	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2						AGCTGTCATGGGCACAGAGTC	0.572			NA											20	52					0	0	0.001216	0	0
TRPC4	7223	broad.mit.edu	37	13	38320115	38320115	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:38320115G>T	uc001uws.2	-	3	1091	c.856C>A	c.(856-858)CTT>ATT	p.L286I	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.L286I|TRPC4_uc010tey.1_Missense_Mutation_p.L286I|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.L286I|TRPC4_uc010aby.2_Missense_Mutation_p.L286I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	286	Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AGTCTTGCAAGATCATTTCCA	0.388			NA											10	203					0.000673444	0.000848041	0.000673	1	0
RB1	5925	broad.mit.edu	37	13	48947605	48947606	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:48947605_48947606GA>TT	uc001vcb.2	+	12	1358_1359	c.1192_1193GA>TT	c.(1192-1194)GAA>TTA	p.E398L	RB1_uc010act.1_Missense_Mutation_p.E99L	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	398	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCAACCTTCAGAAAATCTGATT	0.287			6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			5	197					0	0	0.004672	0	0
KLHL1	57626	broad.mit.edu	37	13	70456453	70456453	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:70456453G>A	uc001vip.2	-	5	1983	c.1189C>T	c.(1189-1191)CTT>TTT	p.L397F	KLHL1_uc010thm.1_Missense_Mutation_p.L336F	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	397					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AAGGCAAGAAGCATGCTCAGG	0.398			NA											5	94					0	0	0.001168	0	0
UGGT2	55757	broad.mit.edu	37	13	96601613	96601613	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:96601613G>A	uc001vmt.2	-	13	1601	c.1431C>T	c.(1429-1431)TCC>TCT	p.S477S		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	477					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TGCGCCTTATGGAAGGTACAC	0.294			NA											21	35					0	0	0.001216	0	0
MYO16	23026	broad.mit.edu	37	13	109699269	109699269	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:109699269G>A	uc001vqt.1	+	24	2862	c.2736G>A	c.(2734-2736)ATG>ATA	p.M912I	MYO16_uc010agk.1_Missense_Mutation_p.M934I|MYO16_uc001vqu.1_Missense_Mutation_p.M712I|MYO16_uc010tjh.1_Missense_Mutation_p.M424I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	912	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCTAGGTAATGTATGATGTTG	0.318			NA											13	113					0	0	0.00245	0	0
COL4A1	1282	broad.mit.edu	37	13	110813626	110813626	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:110813626T>A	uc001vqw.3	-	49	4675	c.4553A>T	c.(4552-4554)GAC>GTC	p.D1518V	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1518	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GTACGAGTAGTCATTTCGTGA	0.517			NA											7	57					0	0	0.00308	0	0
OR11H12	440153	broad.mit.edu	37	14	19378063	19378063	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:19378063C>A	uc010tkp.1	+	1	470	c.470C>A	c.(469-471)GCC>GAC	p.A157D		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	157	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATCTCTGTGCCAAACTGGTC	0.468			NA											38	670					2.12129e-23	4.00687e-23	0.00361	1	0
RNASE13	440163	broad.mit.edu	37	14	21502073	21502073	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:21502073G>T	uc001vzj.2	-	2	513	c.375C>A	c.(373-375)TAC>TAA	p.Y125*	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	125						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		GGGTGCTATTGTAGTAGCAGC	0.498			NA											21	171					1.55795e-14	2.62043e-14	0.001882	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21795901	21795901	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:21795901G>T	uc001wag.2	+	17	2830	c.2830G>T	c.(2830-2832)GGG>TGG	p.G944W	RPGRIP1_uc001wah.2_Missense_Mutation_p.G586W|RPGRIP1_uc001wai.2_Missense_Mutation_p.G270W|RPGRIP1_uc001wak.2_Missense_Mutation_p.G419W|RPGRIP1_uc010aim.2_Missense_Mutation_p.G327W|RPGRIP1_uc001wal.2_Missense_Mutation_p.G303W|RPGRIP1_uc001wam.2_Missense_Mutation_p.G261W	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	944					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TCAGACTAAGGGGAAGGATAC	0.483			NA											18	43					1.02788e-11	1.65295e-11	0.00499	1	0
AKAP6	9472	broad.mit.edu	37	14	33292102	33292102	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:33292102G>A	uc001wrq.2	+	13	5253	c.5083G>A	c.(5083-5085)GAC>AAC	p.D1695N		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1695	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TAGCAGCAGTGACGAGCTCTC	0.463	Melanoma(49;821 1200 7288 13647 42351)		NA											7	132					0	0	0.00308	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35554835	35554835	+	Silent	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:35554835T>G	uc001wss.2	-	13	1677	c.1323A>C	c.(1321-1323)GCA>GCC	p.A441A	PPP2R3C_uc001wst.2_Silent_p.A325A|PPP2R3C_uc010tpr.1_Silent_p.A325A|PPP2R3C_uc001wsu.2_RNA	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	441						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		CACTGTCATTTGCAACAAGAG	0.383			NA											19	73					0	0	0.001882	0	0
MDGA2	161357	broad.mit.edu	37	14	47351411	47351411	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:47351411C>A	uc001wwj.3	-	11	2241	c.2045G>T	c.(2044-2046)CGC>CTC	p.R682L	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Missense_Mutation_p.R453L|MDGA2_uc010ani.2_Missense_Mutation_p.R242L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	682					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CTCCCACCAGCGCTGCTGTCC	0.323			NA											11	49					0.000151284	0.000194625	0.001855	1	0
ATL1	51062	broad.mit.edu	37	14	51058328	51058328	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:51058328G>A	uc001wyf.3	+	4	734	c.493G>A	c.(493-495)GCC>ACC	p.A165T	ATL1_uc001wyd.3_Missense_Mutation_p.A165T|ATL1_uc001wye.3_Missense_Mutation_p.A165T	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	165	Cytoplasmic.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						CACAGTATTTGCCCTTAGCAC	0.353			NA											20	61					0	0	0.001523	0	0
SAMD4A	23034	broad.mit.edu	37	14	55231189	55231189	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:55231189G>T	uc001xbb.2	+	7	1525	c.1524G>T	c.(1522-1524)TTG>TTT	p.L508F	SAMD4A_uc001xbc.2_Missense_Mutation_p.L420F|SAMD4A_uc001xbg.2_Missense_Mutation_p.L100F	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	509					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						CACAGCTCTTGGTCTCCAGAC	0.388			NA											127	205					1.8369e-69	3.78513e-69	0.00361	1	0
LGMN	5641	broad.mit.edu	37	14	93199091	93199091	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:93199091C>A	uc001yav.2	-	3	367	c.41G>T	c.(40-42)GGC>GTC	p.G14V	LGMN_uc001yat.2_Missense_Mutation_p.G14V|LGMN_uc001yau.2_Missense_Mutation_p.G14V|LGMN_uc001yaw.2_Missense_Mutation_p.G14V|LGMN_uc010aul.2_5'UTR|LGMN_uc001yax.2_Missense_Mutation_p.G14V|LGMN_uc001yay.2_Missense_Mutation_p.G14V	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	14					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		GGCACCAATGCCCAGGGCCAC	0.483			NA											32	121					1.06801e-11	1.7117e-11	0.001786	1	0
KIAA1409	57578	broad.mit.edu	37	14	94048570	94048570	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:94048570G>C	uc001ybv.1	+	17	2235	c.2152G>C	c.(2152-2154)GAT>CAT	p.D718H	KIAA1409_uc001ybs.1_Missense_Mutation_p.D718H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	895						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CAGCCTGGAGGATAGCCTCCT	0.562			NA											3	108					0	0	0.004672	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030054	95030054	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:95030054C>A	uc001ydk.2	+	2	301	c.235C>A	c.(235-237)CCG>ACG	p.P79T	SERPINA4_uc010avd.2_Missense_Mutation_p.P116T|SERPINA4_uc001ydl.2_Missense_Mutation_p.P79T	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	79					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CTTTTTCTCCCCGCTGAGCAT	0.612			NA											40	71					2.59497e-14	4.33406e-14	0.007835	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102508450	102508450	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:102508450C>T	uc001yks.2	+	66	12367	c.12203C>T	c.(12202-12204)TCA>TTA	p.S4068L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4068	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CAGATCACTTCAATTGCAATC	0.542			NA											24	45					0	0	0.004656	0	0
TRAF3	7187	broad.mit.edu	37	14	103371649	103371649	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:103371649C>T	uc001ymc.1	+	12	1588	c.1235C>T	c.(1234-1236)GCC>GTC	p.A412V	TRAF3_uc001yme.1_Missense_Mutation_p.A387V|TRAF3_uc001ymd.1_Missense_Mutation_p.A412V|TRAF3_uc010txy.1_Missense_Mutation_p.A329V	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	412					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		CTGGAGACCGCCAGCTACAAT	0.612			NA											22	50					0	0	0.001523	0	0
ADAM6	8755	broad.mit.edu	37	14	106349907	106349907	+	Splice_Site	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr14:106349907G>A	uc010tyt.1	-	3173		c.50075_splice	c.e3173-1							Parts of antibodies, mostly variable regions.												0						AGAGAGCCTGGGGGCTGCTCA	0.677			NA											4	18					0	0	0.000248	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32915737	32915737	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:32915737C>A	uc001zgy.1	+	3	967	c.245C>A	c.(244-246)ACC>AAC	p.T82N	ARHGAP11A_uc010ubw.1_5'UTR|ARHGAP11A_uc001zgw.2_Missense_Mutation_p.T82N|ARHGAP11A_uc001zgx.2_Missense_Mutation_p.T82N|ARHGAP11A_uc010ubx.1_5'UTR	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	82	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CATATTCATACCGAAGGGCTT	0.378	Colon(45;757 1134 30003 36652)		NA											5	74					0.000157383	0.000201383	0.00308	1	0
PML	5371	broad.mit.edu	37	15	74290522	74290522	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:74290522G>T	uc002awv.2	+	2	447	c.307G>T	c.(307-309)GCC>TCC	p.A103S	PML_uc002awm.2_Missense_Mutation_p.A103S|PML_uc002awl.2_Missense_Mutation_p.A103S|PML_uc002awj.1_Missense_Mutation_p.A103S|PML_uc002awk.2_Missense_Mutation_p.A103S|PML_uc002awn.2_Missense_Mutation_p.A103S|PML_uc002awo.2_Missense_Mutation_p.A103S|PML_uc002awp.2_Missense_Mutation_p.A103S|PML_uc002awq.2_Missense_Mutation_p.A103S|PML_uc002awr.2_Missense_Mutation_p.A103S|PML_uc002aws.2_Missense_Mutation_p.A103S|PML_uc002awt.2_Missense_Mutation_p.A103S|PML_uc002awu.2_Missense_Mutation_p.A103S|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.A18S	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	103					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						AGACACACCCGCCCTGGATAA	0.647			NA	T	RARA|PAX5	APL|ALL								6	37					1.06961e-07	1.55224e-07	0.00308	1	0
NTRK3	4916	broad.mit.edu	37	15	88669523	88669523	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:88669523G>C	uc002bme.1	-	12	1537	c.1375C>G	c.(1375-1377)CGG>GGG	p.R459G	NTRK3_uc002bmh.2_Missense_Mutation_p.R451G|NTRK3_uc002bmf.1_Missense_Mutation_p.R459G|NTRK3_uc010upl.1_Missense_Mutation_p.R361G|NTRK3_uc010bnh.1_Missense_Mutation_p.R451G|NTRK3_uc002bmg.2_Missense_Mutation_p.R459G	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	459	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATTTGGACCGTCGACCATAT	0.433			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			14	33					0	0	0.001855	0	0
MFGE8	4240	broad.mit.edu	37	15	89450563	89450563	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:89450563A>G	uc002bng.3	-	3	363	c.250T>C	c.(250-252)TCA>CCA	p.S84P	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Missense_Mutation_p.S84P|MFGE8_uc010bnn.2_Missense_Mutation_p.S76P|MFGE8_uc010upq.1_Missense_Mutation_p.S40P|MFGE8_uc010upr.1_Missense_Mutation_p.S84P|MFGE8_uc010bno.2_Missense_Mutation_p.S40P	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	84	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					GCGATCTGTGAGTTGGCAATG	0.632			NA											5	31					0	0	0.001168	0	0
ABHD2	11057	broad.mit.edu	37	15	89698682	89698682	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:89698682A>G	uc002bnj.2	+	10	1372	c.455A>G	c.(454-456)AAA>AGA	p.K152R	ABHD2_uc002bnk.2_Missense_Mutation_p.K152R	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	152						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TACGCCCAGAAAAATGGCTAT	0.507	Colon(11;252 417 24570 33239 41878)		NA											18	113					0	0	0.006122	0	0
LRRK1	79705	broad.mit.edu	37	15	101464888	101464888	+	Silent	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr15:101464888G>C	uc002bwr.2	+	2	370	c.51G>C	c.(49-51)CCG>CCC	p.P17P	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Silent_p.P17P	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	17					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGTGGGGCCGGAGGAGTCAG	0.592			NA											12	29					0	0	0.00245	0	0
ERCC4	2072	broad.mit.edu	37	16	14029250	14029250	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:14029250G>C	uc002dce.2	+	8	1470	c.1461G>C	c.(1459-1461)AAG>AAC	p.K487N	ERCC4_uc010uyz.1_Missense_Mutation_p.K37N	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	487	Nuclear localization signal (Potential).				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CCCTCAAAAAGAAAAAACGGA	0.408			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				3	46					0	0	0.000248	0	0
XYLT1	64131	broad.mit.edu	37	16	17228489	17228489	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:17228489C>G	uc002dfa.2	-	9	1953	c.1868G>C	c.(1867-1869)GGT>GCT	p.G623A		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	623	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCCCGGGGTACCTGCAGGGTA	0.572			NA											46	120					0	0	0.00361	0	0
DNAH3	55567	broad.mit.edu	37	16	20996905	20996905	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:20996905C>T	uc010vbe.1	-	48	7159	c.7159G>A	c.(7159-7161)GTG>ATG	p.V2387M	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2387					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCCATGACCACAGTCAGCTGT	0.448			NA											8	142					0	0	0.00308	0	0
OTOA	146183	broad.mit.edu	37	16	21698947	21698947	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:21698947C>G	uc002djh.2	+	7	614	c.613C>G	c.(613-615)CGC>GGC	p.R205G	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.R126G	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	205					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCGGGACCTGCGCGAGGATGC	0.428			NA											7	17					0	0	0.001984	0	0
IL21R	50615	broad.mit.edu	37	16	27459937	27459937	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:27459937A>G	uc002doq.1	+	9	1183	c.950A>G	c.(949-951)TAC>TGC	p.Y317C	IL21R_uc002dor.1_Missense_Mutation_p.Y317C|IL21R_uc002dos.1_Missense_Mutation_p.Y317C|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	317	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CTGGAGGTGTACAGCTGCCAC	0.632			NA	T	BCL6	NHL								8	49					0	0	0.00308	0	0
NUPR1	26471	broad.mit.edu	37	16	28550162	28550162	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:28550162T>G	uc002dqe.1	-	1	334	c.67A>C	c.(67-69)AGC>CGC	p.S23R	uc010vct.1_Intron|NUPR1_uc002dqd.1_Missense_Mutation_p.S23R	NM_012385	NP_036517	O60356	NUPR1_HUMAN	p8 protein isoform b	23					cell growth|induction of apoptosis	nucleus					0						TCATCCAGGCTGGAGTCCTCG	0.627			NA											18	56					0	0	0.006122	0	0
KCTD13	253980	broad.mit.edu	37	16	29934554	29934554	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:29934554T>G	uc002duv.2	-	2	562	c.371A>C	c.(370-372)TAC>TCC	p.Y124S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	124					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						CTGCACCAGGTAGTAGCGTGC	0.607			NA											9	31					0	0	0.000673	0	0
FAM57B	83723	broad.mit.edu	37	16	30041831	30041831	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:30041831C>A	uc002dvt.2	-	1	356	c.18G>T	c.(16-18)GTG>GTT	p.V6V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|FAM57B_uc002dvu.2_5'Flank	NM_031478	NP_113666	Q71RH2	FA57B_HUMAN	hypothetical protein LOC83723	6						endoplasmic reticulum|integral to membrane					0						CCCCCCCGGCCACCATCGGGG	0.672			NA											14	22					7.93312e-07	1.09454e-06	0.00245	1	0
PRR14	78994	broad.mit.edu	37	16	30667570	30667570	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:30667570G>A	uc002dyy.2	+	12	1954	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K	PRR14_uc002dyz.2_Missense_Mutation_p.E411K|PRR14_uc002dza.2_Missense_Mutation_p.E566K	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	566											0			Colorectal(24;0.103)			GCGGCTGGAGGAGCTAGATGC	0.642			NA											6	72					0	0	0.001168	0	0
PRSS36	146547	broad.mit.edu	37	16	31157117	31157117	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:31157117G>C	uc002ebd.2	-	6	772	c.713C>G	c.(712-714)ACC>AGC	p.T238S	PRSS36_uc010vff.1_Missense_Mutation_p.T13S|PRSS36_uc010vfg.1_Missense_Mutation_p.T238S|PRSS36_uc010vfh.1_Missense_Mutation_p.T238S	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	238	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CACCTGGCAGGTGTCCCTGCG	0.577			NA											33	102					0	0	0.004289	0	0
BRD7	29117	broad.mit.edu	37	16	50388360	50388360	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:50388360T>C	uc002egf.1	-	5	489	c.422A>G	c.(421-423)AAT>AGT	p.N141S	BRD7_uc002ege.1_Missense_Mutation_p.N141S	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	141					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				CATCAGTTGATTCAAAGCTTC	0.328			NA											31	328					0	0	0.001512	0	0
BCAR1	9564	broad.mit.edu	37	16	75269174	75269174	+	Silent	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:75269174A>T	uc002fdv.2	-	5	1746	c.1623T>A	c.(1621-1623)CTT>CTA	p.L541L	BCAR1_uc002fdt.2_5'UTR|BCAR1_uc002fdu.2_Silent_p.L331L|BCAR1_uc010cgu.2_Silent_p.L530L|BCAR1_uc010vna.1_Silent_p.L539L|BCAR1_uc010vnb.1_Silent_p.L587L|BCAR1_uc002fdw.2_Silent_p.L541L|BCAR1_uc010vnc.1_Silent_p.L393L|BCAR1_uc010vnd.1_Silent_p.L559L|BCAR1_uc002fdx.2_Silent_p.L559L	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	541	Ser-rich.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCTGCCGGCTAAGCTTGGCAT	0.662			NA											14	33					0	0	0.003163	0	0
KLHDC4	54758	broad.mit.edu	37	16	87743082	87743082	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr16:87743082C>A	uc002fki.2	-	10	1282	c.1236G>T	c.(1234-1236)CGG>CGT	p.R412R	KLHDC4_uc002fkh.1_RNA|KLHDC4_uc010cht.1_Intron|KLHDC4_uc002fkj.2_Silent_p.R381R|KLHDC4_uc002fkk.2_Silent_p.R231R|KLHDC4_uc002fkl.2_Silent_p.R355R|KLHDC4_uc010chu.1_Silent_p.R231R	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	412										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CGTCCTCAGACCGGGGCTGCC	0.682			NA											7	15					0.000274275	0.000348147	0.004482	1	0
MYOCD	93649	broad.mit.edu	37	17	12666716	12666716	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:12666716C>G	uc002gnn.2	+	13	2871	c.2572C>G	c.(2572-2574)CCA>GCA	p.P858A	MYOCD_uc002gno.2_Missense_Mutation_p.P906A|MYOCD_uc002gnq.2_Missense_Mutation_p.P582A	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	858					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGAGATCTTGCCAGGCCCCCT	0.498			NA											6	61					0	0	0.001168	0	0
KRT35	3886	broad.mit.edu	37	17	39633867	39633867	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:39633867G>A	uc002hws.2	-	6	1166	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	375	Rod.|Coil 2.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				TGGTTCTGCCGCTCCAGGTCA	0.652			NA											7	97					0	0	0.001984	0	0
NFE2L1	4779	broad.mit.edu	37	17	46128597	46128597	+	Silent	SNP	C	C	T	rs141933946	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:46128597C>T	uc002imz.3	+	2	768	c.117C>T	c.(115-117)CTC>CTT	p.L39L	NFE2L1_uc002ina.3_Silent_p.L39L|NFE2L1_uc002inb.3_Silent_p.L39L|NFE2L1_uc002inc.1_Silent_p.L39L	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	39					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						TTCCCCCACTCCGGGAGATCA	0.522			NA											38	109					0	0	0.00623	0	0
SPAG9	9043	broad.mit.edu	37	17	49079164	49079164	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:49079164C>G	uc002itc.2	-	13	1728	c.1519G>C	c.(1519-1521)GAA>CAA	p.E507Q	SPAG9_uc002itb.2_Missense_Mutation_p.E493Q|SPAG9_uc002itd.2_Missense_Mutation_p.E493Q|SPAG9_uc002itf.2_Missense_Mutation_p.E328Q|SPAG9_uc002ita.2_Missense_Mutation_p.E350Q|SPAG9_uc002ite.2_Missense_Mutation_p.E337Q	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	507	Potential.				positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CGGGCCATTTCTACTCTAGTA	0.413			NA											12	89					0	0	0.001855	0	0
INTS2	57508	broad.mit.edu	37	17	59967149	59967149	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:59967149A>G	uc002izn.2	-	15	2082	c.2006T>C	c.(2005-2007)TTA>TCA	p.L669S	INTS2_uc002izm.2_Missense_Mutation_p.L661S	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	669					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						CAACTTACCTAAAGTCTTCGT	0.368			NA											7	11					0	0	0.001984	0	0
RHBDF2	79651	broad.mit.edu	37	17	74473792	74473792	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:74473792C>A	uc002jrq.1	-	7	1128	c.835G>T	c.(835-837)GAG>TAG	p.E279*	RHBDF2_uc002jrp.1_Nonsense_Mutation_p.E250*|RHBDF2_uc002jrr.1_Nonsense_Mutation_p.E131*|RHBDF2_uc010wtf.1_Nonsense_Mutation_p.E250*|RHBDF2_uc002jrs.1_Nonsense_Mutation_p.E274*	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	279	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						ACATCCTCCTCCAGGAAGCTC	0.637			NA											49	76					9.45407e-15	1.60147e-14	0.00361	1	0
ENPP7	339221	broad.mit.edu	37	17	77709206	77709206	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:77709206G>A	uc002jxa.2	+	3	784	c.764G>A	c.(763-765)CGG>CAG	p.R255Q		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	255					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GTGGACAAACGGGCTGGCGAC	0.597			NA											24	57					0	0	0.001512	0	0
AATK	9625	broad.mit.edu	37	17	79094822	79094822	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:79094822C>G	uc010dia.2	-	11	2994	c.2914G>C	c.(2914-2916)GGC>CGC	p.G972R	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	972						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGCCCGGGGCCCTCACCCTCT	0.622			NA											5	16					0	0	0.001168	0	0
NARF	26502	broad.mit.edu	37	17	80436742	80436742	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr17:80436742C>T	uc002kfg.3	+	6	727	c.587C>T	c.(586-588)TCC>TTC	p.S196F	NARF_uc002kff.3_Missense_Mutation_p.S137F|NARF_uc010wvo.1_Missense_Mutation_p.S151F|NARF_uc010wvp.1_Missense_Mutation_p.S68F|NARF_uc010dit.2_Missense_Mutation_p.S196F|NARF_uc002kfj.3_Missense_Mutation_p.S148F|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.S196F|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	196						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			ACCGCCAAGTCCCCCCAGCAG	0.627			NA											14	33					0	0	0.001855	0	0
AFG3L2	10939	broad.mit.edu	37	18	12356752	12356752	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:12356752A>G	uc002kqz.1	-	9	1218	c.1105T>C	c.(1105-1107)TTC>CTC	p.F369L		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	369					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	ACGGTGATGAAGGGGACATTG	0.512			NA											3	67					0	0	0.004672	0	0
CEP192	55125	broad.mit.edu	37	18	13087217	13087217	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:13087217G>C	uc010xac.1	+	31	5898	c.5818G>C	c.(5818-5820)GAT>CAT	p.D1940H	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.D1465H|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.D362H|CEP192_uc002krw.2_Missense_Mutation_p.D89H|CEP192_uc002krx.2_5'UTR|CEP192_uc002kry.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1940										ovary(4)|pancreas(1)	5						AGTTTTGCTGGATCCTAAAGT	0.343			NA											3	72					0	0	0.004672	0	0
MIB1	57534	broad.mit.edu	37	18	19345792	19345792	+	Nonsense_Mutation	SNP	C	C	T	rs151095403		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:19345792C>T	uc002ktq.2	+	2	289	c.289C>T	c.(289-291)CGA>TGA	p.R97*	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	97	ZZ-type.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			CATTGGCATTCGATGGAAGTG	0.393			NA											12	61					0	0	0.001368	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997690	19997690	+	Silent	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:19997690A>G	uc002ktv.1	-	1	189	c.85T>C	c.(85-87)TTG>CTG	p.L29L		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	29	Helical; (Potential).					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CTTCTCCACAAGAAGAGAACA	0.408			NA											13	38					0	0	0.001368	0	0
ASXL3	80816	broad.mit.edu	37	18	31324042	31324042	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:31324042C>A	uc010dmg.1	+	12	4285	c.4230C>A	c.(4228-4230)CAC>CAA	p.H1410Q	ASXL3_uc002kxq.2_Missense_Mutation_p.H1117Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGGTTGCACACCCGACCGTCG	0.498			NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	158					5.7616e-29	1.12398e-28	0.00361	1	0
CELF4	56853	broad.mit.edu	37	18	34850743	34850743	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr18:34850743G>T	uc002lae.2	-	8	1483	c.1087C>A	c.(1087-1089)CAC>AAC	p.H363N	CELF4_uc010dnd.1_Missense_Mutation_p.H361N|CELF4_uc002lag.2_Missense_Mutation_p.H353N|CELF4_uc002laf.2_Missense_Mutation_p.H358N|CELF4_uc002lai.2_Missense_Mutation_p.H348N|CELF4_uc002lah.1_Missense_Mutation_p.H88N	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	363					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GGGTAGGGGTGGATGCCATTG	0.557			NA											22	72					1.9806e-07	2.83113e-07	0.002299	1	0
GPR108	56927	broad.mit.edu	37	19	6731116	6731116	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:6731116C>T	uc002mfp.2	-	17	1487	c.1441G>A	c.(1441-1443)GTG>ATG	p.V481M	GPR108_uc010duv.2_Missense_Mutation_p.V32M|GPR108_uc002mfn.2_Missense_Mutation_p.V136M|GPR108_uc002mfo.3_Missense_Mutation_p.V239M|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	481	Helical; Name=7; (Potential).					integral to membrane					0						GAGCCCTCCACCAAGAGCTGG	0.701			NA											6	39					0	0	0.001984	0	0
FCER2	2208	broad.mit.edu	37	19	7754258	7754258	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:7754258G>A	uc002mhn.2	-	11	971	c.787C>T	c.(787-789)CGG>TGG	p.R263W	FCER2_uc010xjs.1_Missense_Mutation_p.R185W|FCER2_uc010xjt.1_Missense_Mutation_p.R185W|FCER2_uc002mhm.2_Missense_Mutation_p.R263W	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	263	C-type lectin.|Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						CCGGAGCCCCGCATCATCACG	0.687			NA											5	14					0	0	0.000602	0	0
HNRNPM	4670	broad.mit.edu	37	19	8550609	8550609	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:8550609G>A	uc010dwe.2	+	14	1377	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	HNRNPM_uc010xke.1_Missense_Mutation_p.E379K|HNRNPM_uc010dwd.2_Missense_Mutation_p.E394K|HNRNPM_uc002mka.2_Missense_Mutation_p.E298K|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	433	5.|27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						CGTGGGCTCCGAGATCGAGCG	0.706			NA											12	131					0	0	0.000978	0	0
MUC16	94025	broad.mit.edu	37	19	9048993	9048993	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:9048993G>C	uc002mkp.2	-	5	32842	c.32638C>G	c.(32638-32640)CCT>GCT	p.P10880A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10882	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGACCAAAGGGGTCACTACT	0.493			NA											27	114					0	0	0.004656	0	0
OR7G2	390882	broad.mit.edu	37	19	9213076	9213076	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:9213076G>T	uc010xkk.1	-	1	907	c.907C>A	c.(907-909)CCT>ACT	p.P303T		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACCATTTGAGGGAACACAGAA	0.458	Esophageal Squamous(67;143 1448 28637 40648)		NA											24	58					7.88262e-20	1.42126e-19	0.00333	1	0
KANK2	25959	broad.mit.edu	37	19	11303645	11303645	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:11303645C>A	uc010dxv.2	-	6	1669	c.1111G>T	c.(1111-1113)GGT>TGT	p.G371C	KANK2_uc002mqm.2_Missense_Mutation_p.G371C|KANK2_uc002mqo.3_Missense_Mutation_p.G371C|KANK2_uc002mqp.1_Missense_Mutation_p.G180C|KANK2_uc002mqq.2_Missense_Mutation_p.G371C	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	371											0						TCAGGCCTACCAGGCATTGCC	0.667			NA											17	42					5.3912e-06	7.26973e-06	0.006122	1	0
ZNF442	79973	broad.mit.edu	37	19	12461717	12461717	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:12461717C>A	uc002mtr.1	-	6	1293	c.682G>T	c.(682-684)GAA>TAA	p.E228*	ZNF442_uc010xmk.1_Nonsense_Mutation_p.E159*	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	228	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TGAGTTCTTTCATGCATACGA	0.393			NA											37	117					2.20474e-14	3.69526e-14	0.003755	1	0
DNASE2	1777	broad.mit.edu	37	19	12986926	12986926	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:12986926G>A	uc002mvn.1	-	6	1107	c.961C>T	c.(961-963)CGG>TGG	p.R321W	DNASE2_uc010xmr.1_Missense_Mutation_p.R266W	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	321					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						CCCCCACCCCGTTGCTCCTCT	0.607			NA						Direct_reversal_of_damage					13	71					0	0	0.001368	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760641	19760641	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:19760641C>A	uc002nnh.3	-	18	2472	c.2444G>T	c.(2443-2445)GGC>GTC	p.G815V	ATP13A1_uc002nne.2_5'UTR|ATP13A1_uc002nnf.3_Missense_Mutation_p.G183V|ATP13A1_uc002nng.2_Missense_Mutation_p.G697V	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	815	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						GTGGGCCAAGCCGTCGCCTGT	0.677	Esophageal Squamous(142;920 1789 9047 14684 24777)		NA											5	41					0.00116845	0.00145979	0.001168	1	0
C19orf2	8725	broad.mit.edu	37	19	30498451	30498451	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:30498451G>C	uc002nsr.2	+	7	622	c.592G>C	c.(592-594)GAT>CAT	p.D198H	C19orf2_uc002nsq.2_Missense_Mutation_p.D180H|C19orf2_uc002nss.2_Missense_Mutation_p.D158H|C19orf2_uc002nst.2_Missense_Mutation_p.D122H	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	198					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		TATTGCAAATGATGTGAAATC	0.383	Melanoma(75;661 1306 1472 28422 37948)		NA											6	36					0	0	0.001168	0	0
HKR1	284459	broad.mit.edu	37	19	37854368	37854368	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:37854368G>T	uc002ogb.2	+	6	1940	c.1671G>T	c.(1669-1671)GAG>GAT	p.E557D	HKR1_uc002ofx.2_Missense_Mutation_p.E273D|HKR1_uc002ofy.2_Missense_Mutation_p.E273D|HKR1_uc002oga.2_Missense_Mutation_p.E539D|HKR1_uc010xto.1_Missense_Mutation_p.E539D|HKR1_uc002ogc.2_Missense_Mutation_p.E538D|HKR1_uc010xtp.1_Missense_Mutation_p.E496D|HKR1_uc002ogd.2_Missense_Mutation_p.E496D	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	557	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGCAGGGAGTGTGGCAGAA	0.502			NA											21	34					1.50039e-11	2.37271e-11	0.001882	1	0
FCGBP	8857	broad.mit.edu	37	19	40368642	40368642	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:40368642C>A	uc002omp.3	-	28	12714	c.12706G>T	c.(12706-12708)GCT>TCT	p.A4236S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4236	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ATGGAGGGAGCCAGTGTGCCA	0.642			NA											15	203					1.50039e-11	2.37271e-11	0.001882	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41782090	41782090	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:41782090G>T	uc002oqb.3	+	5	962	c.673G>T	c.(673-675)GCC>TCC	p.A225S	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.A125S|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.A125S|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.A225S|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.A182S|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.A125S|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.A125S|HNRNPUL1_uc010eho.2_Missense_Mutation_p.A125S|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.A125S|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.A81S|HNRNPUL1_uc010ehl.1_Missense_Mutation_p.A125S	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	225	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CTTCAAGGTGGCCCGAGATCG	0.443			NA											38	95					2.87052e-16	4.93273e-16	0.005524	1	0
MEGF8	1954	broad.mit.edu	37	19	42867243	42867243	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:42867243G>T	uc002otl.3	+	34	6536	c.5901G>T	c.(5899-5901)TGG>TGT	p.W1967C	MEGF8_uc002otm.3_Missense_Mutation_p.W1575C	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2034	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCTATGACTGGACGTGCTTCA	0.532			NA											8	16					5.4927e-09	8.30008e-09	0.004482	1	0
PSG4	5672	broad.mit.edu	37	19	43698709	43698709	+	Silent	SNP	G	G	C	rs146368793		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:43698709G>C	uc002ovy.2	-	5	1128	c.1026C>G	c.(1024-1026)ACC>ACG	p.T342T	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_Intron|PSG4_uc002owb.2_Silent_p.T249T|PSG4_uc002ovz.2_Silent_p.T249T	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	342	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				AACGGTAATAGGTGAATGAAG	0.488			NA											79	209					0	0	0.00361	0	0
ZNF235	9310	broad.mit.edu	37	19	44792687	44792687	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:44792687T>C	uc002oza.3	-	5	1004	c.901A>G	c.(901-903)AGT>GGT	p.S301G	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.S297G|ZNF235_uc010xwx.1_Missense_Mutation_p.S215G	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				GAGCTATAACTGGTGTCCTTC	0.418			NA											6	78					0	0	0.001984	0	0
SYMPK	8189	broad.mit.edu	37	19	46326729	46326729	+	Silent	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:46326729G>C	uc002pdn.2	-	20	2846	c.2601C>G	c.(2599-2601)GTC>GTG	p.V867V	SYMPK_uc002pdo.1_Silent_p.V867V|SYMPK_uc002pdp.1_Silent_p.V867V	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	867					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGGAGGGTGGGACTGCATGGA	0.637			NA											3	31					0	0	0.004672	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979147	50979147	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:50979147C>T	uc002psh.2	-	2	661	c.303G>A	c.(301-303)CAG>CAA	p.Q101Q	FAM71E1_uc002psg.2_Silent_p.Q101Q|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	101										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		ATTCGCCGCTCTGGAGGTAGC	0.627			NA											11	9					0	0	0.001855	0	0
KLK2	3817	broad.mit.edu	37	19	51379887	51379887	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:51379887G>T	uc002ptv.2	+	3	407	c.366G>T	c.(364-366)ATG>ATT	p.M122I	KLK2_uc010eog.2_Missense_Mutation_p.M20I|KLK2_uc010yck.1_Missense_Mutation_p.M122I|KLK2_uc002ptu.2_Missense_Mutation_p.M122I|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Missense_Mutation_p.M105I|KLK2_uc010ycm.1_Missense_Mutation_p.M20I|KLK2_uc010eoh.2_Missense_Mutation_p.M20I	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	122	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		ATGACCTCATGCTGCTCCGCC	0.587			NA	T	ETV4	prostate								24	34					1.64293e-13	2.69668e-13	0.00333	1	0
C19orf75	284369	broad.mit.edu	37	19	51768813	51768813	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:51768813C>A	uc002pwb.1	+	3	595	c.214C>A	c.(214-216)CTA>ATA	p.L72I	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	72						integral to membrane				ovary(1)|pancreas(1)	2						CACCATCAGCCTAACTGAAGA	0.557			NA											13	70					5.50884e-06	7.36575e-06	0.001368	1	0
NLRP2	55655	broad.mit.edu	37	19	55494060	55494060	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:55494060C>A	uc002qij.2	+	6	1080	c.994C>A	c.(994-996)CTG>ATG	p.L332M	NLRP2_uc010yfp.1_Missense_Mutation_p.L309M|NLRP2_uc010esn.2_Missense_Mutation_p.L308M|NLRP2_uc010eso.2_Missense_Mutation_p.L329M|NLRP2_uc010esp.2_Missense_Mutation_p.L310M	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	332	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CAAGGCCGCCCTGCTGGTCAC	0.652			NA											6	27					0.00116845	0.00145979	0.001168	1	0
ZNF530	348327	broad.mit.edu	37	19	58117956	58117956	+	Missense_Mutation	SNP	G	G	A	rs35182752		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:58117956G>A	uc002qpk.2	+	3	1283	c.1063G>A	c.(1063-1065)GAA>AAA	p.E355K	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	355	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGAGTGCAGTGAATGTGGAAA	0.463			NA											6	116					0	0	0.001984	0	0
ZNF587	84914	broad.mit.edu	37	19	58262174	58262174	+	Translation_Start_Site	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:58262174G>A	uc002qqb.2	+	2	318	c.-455G>A	c.(-457--453)ATGTG>ATATG		ZNF776_uc002qpx.2_Missense_Mutation_p.V19M|ZNF776_uc002qqa.2_Missense_Mutation_p.V19M	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CTTTGAAGATGTGGCTGTGAA	0.488	Pancreas(59;641 1233 1885 20055 50741)		NA											10	139					0	0	0.001368	0	0
ZNF586	54807	broad.mit.edu	37	19	58287980	58287980	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:58287980C>A	uc002qqd.2	+	2	292	c.106C>A	c.(106-108)CAG>AAG	p.Q36K	ZNF587_uc002qqb.2_Intron|ZNF586_uc002qqe.2_Intron|ZNF586_uc010euh.2_5'UTR|ZNF586_uc002qqf.1_Intron	NM_017652	NP_060122	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAATGAGGCTCAGAGATGCCT	0.468			NA											47	220					4.64027e-19	8.30363e-19	0.00361	1	0
ZNF418	147686	broad.mit.edu	37	19	58439157	58439157	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr19:58439157T>A	uc002qqs.1	-	4	684	c.392A>T	c.(391-393)TAC>TTC	p.Y131F	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.Y46F	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CTCTCCAAGGTACTGATTCTG	0.453			NA											17	163					0	0	0.00499	0	0
MYT1L	23040	broad.mit.edu	37	2	1893159	1893159	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:1893159G>T	uc002qxe.2	-	16	3201	c.2374C>A	c.(2374-2376)CCT>ACT	p.P792T	MYT1L_uc002qxd.2_Missense_Mutation_p.P790T|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	792					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGCTCCAGAGGGGTCAGGATG	0.622			NA											25	74					1.64293e-13	2.69668e-13	0.00333	1	0
NBAS	51594	broad.mit.edu	37	2	15496520	15496520	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:15496520G>T	uc002rcc.1	-	33	3864	c.3838C>A	c.(3838-3840)CGG>AGG	p.R1280R	NBAS_uc010exl.1_Silent_p.R352R|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1280										ovary(2)|liver(1)|skin(1)	4						ACCTGTCCCCGCCTTTCTTCT	0.453			NA											18	81					2.94398e-08	4.36553e-08	0.007413	1	0
MSH6	2956	broad.mit.edu	37	2	48033436	48033436	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:48033436C>G	uc002rwd.3	+	8	3892	c.3740C>G	c.(3739-3741)ACT>AGT	p.T1247S	MSH6_uc010fbj.2_Missense_Mutation_p.T945S|MSH6_uc010yoi.1_Missense_Mutation_p.T1117S|MSH6_uc010yoj.1_Missense_Mutation_p.T945S	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	1247					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTATTTTCAACTCACTACCAT	0.353			NA	Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				6	84					0	0	0.00308	0	0
WDR54	84058	broad.mit.edu	37	2	74650614	74650614	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:74650614T>G	uc002slb.2	+	5	422	c.362T>G	c.(361-363)GTG>GGG	p.V121G		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	121	WD 1.										0						GTACAGGCTGTGTTTGCCCGG	0.587			NA											23	62					0	0	0.005443	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529975	80529975	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:80529975C>A	uc002sok.1	-	2	1240	c.970G>T	c.(970-972)GCC>TCC	p.A324S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	324	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GAGGCTAGGGCACACACGTTG	0.642			NA								HNSCC(69;0.2)			4	24					1.024e-07	1.49517e-07	0.000602	1	0
ACTR1B	10120	broad.mit.edu	37	2	98277062	98277062	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:98277062C>A	uc002syb.2	-	3	369	c.161G>T	c.(160-162)GGG>GTG	p.G54V		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	54						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						GAAGAGGTCCCCCTCCAGGGC	0.607			NA											24	85					3.17567e-06	4.31891e-06	0.001512	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460276	107460276	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:107460276G>A	uc002tdq.2	-	2	277	c.158C>T	c.(157-159)CCG>CTG	p.P53L	ST6GAL2_uc002tdr.2_Missense_Mutation_p.P53L|ST6GAL2_uc002tds.3_Missense_Mutation_p.P53L	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	53	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CCCCTGCACCGGCAGGAGCCT	0.682			NA											8	41					0	0	0.00308	0	0
SAP130	79595	broad.mit.edu	37	2	128712558	128712558	+	Splice_Site	SNP	A	A	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:128712558A>C	uc002tpp.2	-	15	2527	c.2395_splice	c.e15+1	p.A799_splice	SAP130_uc002tpn.2_Splice_Site_p.A559_splice|SAP130_uc002tpo.2_Splice_Site_p.A579_splice|SAP130_uc010fmd.2_Splice_Site_p.A834_splice	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b						histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		GGACGGACTTACCAGAAACTG	0.488			NA											12	72					0	0	0.00245	0	0
LRP1B	53353	broad.mit.edu	37	2	142238044	142238044	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:142238044G>T	uc002tvj.1	-	3	1236	c.264C>A	c.(262-264)AAC>AAA	p.N88K	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	88	Extracellular (Potential).|LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAACACATTTGTTGGTACCAA	0.433	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			5	56					1.23904e-05	1.63375e-05	0.000602	1	0
DLX2	1746	broad.mit.edu	37	2	172966194	172966194	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:172966194G>T	uc002uhn.2	-	2	793	c.581C>A	c.(580-582)ACT>AAT	p.T194N	DLX2_uc010zdx.1_Missense_Mutation_p.T194N	NM_004405	NP_004396	Q07687	DLX2_HUMAN	distal-less homeobox 2	194	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CCCCACCTGAGTCTGGGTGAG	0.602	GBM(188;775 2993 11256 23072)		NA											3	10					6.4e-05	8.36923e-05	0.004672	1	0
TTC30A	92104	broad.mit.edu	37	2	178483345	178483345	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:178483345C>T	uc002ulo.2	-	1	350	c.85G>A	c.(85-87)GAG>AAG	p.E29K		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	29	TPR 1.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			TGCACCGCCTCGGCGTAGCGG	0.677			NA											5	21					0	0	0.000602	0	0
DFNB59	494513	broad.mit.edu	37	2	179320856	179320856	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:179320856G>T	uc002umi.3	+	4	883	c.527G>T	c.(526-528)GGA>GTA	p.G176V	DFNB59_uc002umj.3_Missense_Mutation_p.G176V	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	176					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			GTGCATGCTGGAATTCGAGGG	0.453			NA											12	26					1.08611e-07	1.5619e-07	0.000978	1	0
TTN	7273	broad.mit.edu	37	2	179592313	179592313	+	Silent	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:179592313T>A	uc010zfg.1	-	65	16484	c.16260A>T	c.(16258-16260)ACA>ACT	p.T5420T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T2081T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6347							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGCACACCTGTCACAAGCA	0.378			NA											17	227					0	0	0.007413	0	0
PMS1	5378	broad.mit.edu	37	2	190738322	190738322	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:190738322A>T	uc002urh.3	+	12	3103	c.2574A>T	c.(2572-2574)TTA>TTT	p.L858F	PMS1_uc002urk.3_Missense_Mutation_p.L819F|PMS1_uc002uri.3_Missense_Mutation_p.L696F|PMS1_uc010zgc.1_Missense_Mutation_p.L682F|PMS1_uc010zgd.1_Missense_Mutation_p.L682F|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_3'UTR|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.L481F|PMS1_uc002urm.2_RNA	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	858					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			ATGCTATATTAAACAGAAATG	0.279			NA	Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					38	77					0	0	0.005524	0	0
PLCL1	5334	broad.mit.edu	37	2	198949108	198949108	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:198949108G>T	uc010fsp.2	+	2	1158	c.867G>T	c.(865-867)AAG>AAT	p.K289N	PLCL1_uc002uuv.3_Missense_Mutation_p.K210N	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	289					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAATCCAGAAGAGCAAGGAAA	0.403			NA											8	129					5.4927e-09	8.30008e-09	0.004482	1	0
PLCL1	5334	broad.mit.edu	37	2	198950297	198950297	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:198950297C>G	uc010fsp.2	+	2	2347	c.2056C>G	c.(2056-2058)CTT>GTT	p.L686V	PLCL1_uc002uuv.3_Missense_Mutation_p.L607V	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	686	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GGGCTGGTTTCTTCAAAACGG	0.453			NA											5	140					0	0	0.000602	0	0
MDH1B	130752	broad.mit.edu	37	2	207621721	207621721	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:207621721A>C	uc002vbs.2	-	4	369	c.314T>G	c.(313-315)ATG>AGG	p.M105R	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.M105R|MDH1B_uc010fuj.2_Missense_Mutation_p.M7R|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	105					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		AGCAATTACCATCATCAGTTC	0.418	Pancreas(76;29 1355 28675 37177 51207)		NA											14	53					0	0	0.004007	0	0
IDH1	3417	broad.mit.edu	37	2	209103826	209103826	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:209103826C>A	uc002vcs.2	-	9	1369	c.1123G>T	c.(1123-1125)GAC>TAC	p.D375Y	IDH1_uc002vct.2_Missense_Mutation_p.D375Y|IDH1_uc002vcu.2_Missense_Mutation_p.D375Y	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	375					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GCAGCCAAGTCCTTGGTCATG	0.423	Pancreas(158;264 1958 3300 35450 36047)		NA	Mis		gliobastoma 								19	79					1.78486e-19	3.20602e-19	0.007413	1	0
IDH1	3417	broad.mit.edu	37	2	209104696	209104696	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:209104696C>A	uc002vcs.2	-	8	1128	c.882G>T	c.(880-882)GTG>GTT	p.V294V	IDH1_uc002vct.2_Silent_p.V294V|IDH1_uc002vcu.2_Silent_p.V294V	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	294					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GACAAACCAGCACGCTGGTCA	0.542	Pancreas(158;264 1958 3300 35450 36047)		NA	Mis		gliobastoma 								25	61					5.61819e-17	9.79581e-17	0.005443	1	0
CCDC108	255101	broad.mit.edu	37	2	219890792	219890792	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:219890792G>A	uc002vjl.1	-	14	2385	c.2301C>T	c.(2299-2301)TTC>TTT	p.F767F		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	767						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAAAGCCAGCGAAATAGCTGT	0.597			NA											5	59					0	0	0.000602	0	0
ALPP	250	broad.mit.edu	37	2	233246046	233246046	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:233246046C>T	uc002vsq.2	+	10	1443	c.1278C>T	c.(1276-1278)GGC>GGT	p.G426G	ALPP_uc002vsr.2_RNA	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	426						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TCAAGGACGGCGCCCGGCCGG	0.697			NA											6	74					0	0	0.001984	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590853	234590853	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:234590853C>T	uc002vut.2	+	1	270	c.270C>T	c.(268-270)TTC>TTT	p.F90F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Silent_p.F90F	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	90					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ACCGGGAGTTCATGGTTTTTG	0.433			NA											55	139					0	0	0.00361	0	0
HDAC4	9759	broad.mit.edu	37	2	239988418	239988418	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:239988418C>A	uc002vyk.3	-	24	3780	c.2988G>T	c.(2986-2988)GAG>GAT	p.E996D	HDAC4_uc010fyy.2_Missense_Mutation_p.E953D	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	996	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GTCTTCCTACCTCGTTTCCCA	0.637			NA											53	126					3.21867e-24	6.12835e-24	0.00361	1	0
GPR35	2859	broad.mit.edu	37	2	241569993	241569993	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:241569993G>A	uc002vzs.1	+	1	1199	c.624G>A	c.(622-624)CAG>CAA	p.Q208Q	GPR35_uc010fzh.1_Silent_p.Q239Q|GPR35_uc010fzi.1_Silent_p.Q239Q	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	208	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		ACGTGGGGCAGGCAGAGGCCA	0.687			NA											21	28					0	0	0.001523	0	0
AQP12B	653437	broad.mit.edu	37	2	241622061	241622061	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:241622061C>A	uc010fzj.2	-	1	257	c.194G>T	c.(193-195)GGG>GTG	p.G65V	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	53						integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CCCAAAGTCCCCAGCCCAGGG	0.701			NA											20	32					1.33834e-09	2.06165e-09	0.007413	1	0
MYH7B	57644	broad.mit.edu	37	20	33578063	33578063	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:33578063G>C	uc002xbi.1	+	20	2145	c.2053G>C	c.(2053-2055)GAG>CAG	p.E685Q	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	643	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGGGGTGAAAGAGAAGCGTAA	0.597			NA											5	252					0	0	0.001984	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060507	35060507	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:35060507C>T	uc002xff.2	+	3	822	c.387C>T	c.(385-387)GCC>GCT	p.A129A	DLGAP4_uc010zvp.1_Silent_p.A129A	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	129					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GTGGCGAGGCCAAGGCCCGTG	0.642			NA											25	232					0	0	0.00333	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547132	37547132	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:37547132G>T	uc002xje.2	+	11	1716	c.1527G>T	c.(1525-1527)ACG>ACT	p.T509T	PPP1R16B_uc010ggc.2_Silent_p.T467T	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	509					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGGCCAGGACGGGCGAGAGTA	0.622			NA											22	21					5.26018e-13	8.57481e-13	0.001882	1	0
CASS4	57091	broad.mit.edu	37	20	55027049	55027050	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:55027049_55027050CC>AA	uc002xxp.2	+	6	1042_1043	c.817_818CC>AA	c.(817-819)CCC>AAC	p.P273N	CASS4_uc002xxq.3_Missense_Mutation_p.P273N|CASS4_uc002xxr.2_Missense_Mutation_p.P273N|CASS4_uc010zze.1_Missense_Mutation_p.P219N|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	273					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CCACGCTCTCCCCAGTTCCAGC	0.515			NA											37	176					0	0	0.004672	0	0
EDN3	1908	broad.mit.edu	37	20	57876513	57876513	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:57876513C>T	uc002yap.2	+	2	470	c.101C>T	c.(100-102)TCC>TTC	p.S34F	EDN3_uc002yao.1_Missense_Mutation_p.S34F|EDN3_uc002yaq.2_Missense_Mutation_p.S34F|EDN3_uc002yar.2_Missense_Mutation_p.S34F|EDN3_uc002yas.2_Missense_Mutation_p.S34F	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	34					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					CGCGGCGTGTCCCAGGCCCCC	0.657			NA											78	31					0	0	0.00361	0	0
C20orf20	55257	broad.mit.edu	37	20	61430850	61430850	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr20:61430850C>G	uc002ydi.2	+	5	541	c.470C>G	c.(469-471)TCC>TGC	p.S157C		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	157					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					TCAGAAAAATCCAGCAAAGAC	0.453			NA											9	170					0	0	0.004482	0	0
TPTE	7179	broad.mit.edu	37	21	10908861	10908861	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr21:10908861T>C	uc002yip.1	-	23	1852	c.1484A>G	c.(1483-1485)TAC>TGC	p.Y495C	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.Y477C|TPTE_uc002yir.1_Missense_Mutation_p.Y457C|TPTE_uc010gkv.1_Missense_Mutation_p.Y357C	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	495	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAACCAGAAGTAAAATGAGCA	0.279			NA											4	97					0	0	0.000602	0	0
NRIP1	8204	broad.mit.edu	37	21	16339433	16339433	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr21:16339433C>A	uc002yjx.2	-	4	1679	c.1081G>T	c.(1081-1083)GGT>TGT	p.G361C		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	361					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TTCTTATAACCTGCATTTTTA	0.363			NA											51	100					3.07002e-29	6.01369e-29	0.00361	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19687463	19687463	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr21:19687463C>A	uc002ykw.2	-	17	2063	c.2032G>T	c.(2032-2034)GTG>TTG	p.V678L		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	678	Extracellular (Potential).|LDL-receptor class A 2.|SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TAAGACATACCACAATCTGCT	0.398			NA											10	83					7.48243e-07	1.03536e-06	0.006214	1	0
TIAM1	7074	broad.mit.edu	37	21	32559330	32559330	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr21:32559330T>A	uc002yow.1	-	15	3121	c.2649A>T	c.(2647-2649)TTA>TTT	p.L883F	TIAM1_uc011adk.1_Missense_Mutation_p.L883F|TIAM1_uc011adl.1_Missense_Mutation_p.L823F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	883	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCTTGGAAGCTAAACCGGTTT	0.438			NA											109	176					0	0	0.00361	0	0
PRMT2	3275	broad.mit.edu	37	21	48064292	48064292	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr21:48064292G>T	uc002zjx.2	+	5	533	c.219G>T	c.(217-219)GCG>GCT	p.A73A	PRMT2_uc002zjw.2_Silent_p.A73A|PRMT2_uc002zjy.2_Silent_p.A73A|PRMT2_uc010gqm.2_Silent_p.A73A|PRMT2_uc011aga.1_Silent_p.A73A|PRMT2_uc011agb.1_Silent_p.A73A|PRMT2_uc011agc.1_Silent_p.A73A|PRMT2_uc002zjz.1_5'UTR	NM_206962	NP_996845	P55345	ANM2_HUMAN	HMT1 hnRNP methyltransferase-like 1	73	SH3.				developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		GTGAGCGTGCGGGCTGCTGTG	0.488			NA											54	67					9.22156e-22	1.70134e-21	0.00361	1	0
MICAL3	57553	broad.mit.edu	37	22	18301725	18301725	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:18301725C>A	uc002zng.3	-	26	4055	c.3702G>T	c.(3700-3702)AGG>AGT	p.R1234S	MICAL3_uc011agl.1_Missense_Mutation_p.R1150S	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1234	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AGACAGGAGTCCTAGCTTCTG	0.652			NA											9	21					0.00448238	0.005499	0.004482	1	0
NEFH	4744	broad.mit.edu	37	22	29881765	29881765	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:29881765C>A	uc003afo.2	+	3	1208	c.1137C>A	c.(1135-1137)GCC>GCA	p.A379A		NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	379	Coil 2B.|Rod.				cell death|nervous system development	neurofilament					0						GGGAGATGGCCGCCCAGCTGC	0.572			NA											12	43					4.3838e-07	6.10143e-07	0.001855	1	0
TBC1D10A	83874	broad.mit.edu	37	22	30688782	30688782	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:30688782C>A	uc011akt.1	-	11	1133	c.1109G>T	c.(1108-1110)CGG>CTG	p.R370L	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Missense_Mutation_p.R228L|TBC1D10A_uc003ahj.3_Missense_Mutation_p.R282L|TBC1D10A_uc010gvu.2_Missense_Mutation_p.R377L|TBC1D10A_uc003ahk.3_Missense_Mutation_p.R370L	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	370						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CTGCCAGCGCCGCAGCTGAAT	0.647			NA											3	22					0.004672	0.00570224	0.004672	1	0
CSF2RB	1439	broad.mit.edu	37	22	37333578	37333578	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:37333578C>A	uc003aqa.3	+	14	1945	c.1728C>A	c.(1726-1728)GCC>GCA	p.A576A	CSF2RB_uc003aqc.3_Silent_p.A582A	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	576	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CGCCTGCCGCCTCCCACACAC	0.657			NA											5	22					0.00448238	0.005499	0.004482	1	0
TMEM184B	25829	broad.mit.edu	37	22	38620938	38620938	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:38620938T>A	uc003avf.1	-	8	1060	c.836A>T	c.(835-837)CAC>CTC	p.H279L	TMEM184B_uc003avg.1_Missense_Mutation_p.H279L|TMEM184B_uc003avh.1_Missense_Mutation_p.H213L	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	279						integral to membrane					0	Melanoma(58;0.045)					GCGGGCCGAGTGGATTTTGGG	0.632			NA											5	14					0	0	0.000602	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39358206	39358206	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:39358206G>T	uc003awn.2	+	4	743	c.573G>T	c.(571-573)CGG>CGT	p.R191R	APOBEC3A_uc011aob.1_Silent_p.R173R|APOBEC3A_uc011aoc.1_Silent_p.R191R	NM_145699	NP_663745	P31941	ABC3A_HUMAN	phorbolin 1	191					cellular response to xenobiotic stimulus|defense response to virus|DNA cytosine deamination|DNA demethylation|innate immune response|negative regulation of transposition|negative regulation of viral genome replication	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					GGAGGCTGCGGGCCATTCTCC	0.468			NA											14	52					0.000151284	0.000194625	0.001855	1	0
TNRC6B	23112	broad.mit.edu	37	22	40661419	40661419	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr22:40661419C>T	uc011aor.1	+	5	1396	c.1185C>T	c.(1183-1185)CCC>CCT	p.P395P	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Silent_p.P395P|TNRC6B_uc003ayo.2_Silent_p.P199P	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	395					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						AGGGAATGCCCTTTGGAATGG	0.478			NA											12	38					0	0	0.000978	0	0
SCN11A	11280	broad.mit.edu	37	3	38991610	38991610	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:38991610C>A	uc011ays.1	-	1	443	c.244G>T	c.(244-246)GAC>TAC	p.D82Y		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	82					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TAGAATGGGTCCAAGTCTTCC	0.443			NA											29	79					5.61819e-17	9.79581e-17	0.005443	1	0
CX3CR1	1524	broad.mit.edu	37	3	39307362	39307362	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:39307362T>G	uc003cjl.2	-	2	731	c.639A>C	c.(637-639)AGA>AGC	p.R213S		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	213	Helical; Name=5; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TCTGGATGATTCTGAAGTAGC	0.478			NA											43	101					0	0	0.002222	0	0
FYCO1	79443	broad.mit.edu	37	3	46014653	46014653	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:46014653C>A	uc003cpb.3	-	6	672	c.466G>T	c.(466-468)GAG>TAG	p.E156*	FYCO1_uc011bal.1_Nonsense_Mutation_p.E156*	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	156	RUN.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCAGTCAGCTCATAGAGTTGG	0.478			NA											45	56					3.7052e-28	7.19868e-28	0.003214	1	0
DNASE1L3	1776	broad.mit.edu	37	3	58183597	58183597	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:58183597C>A	uc003djo.1	-	6	752	c.655G>T	c.(655-657)GAC>TAC	p.D219Y	DNASE1L3_uc011bfd.1_Missense_Mutation_p.D189Y|DNASE1L3_uc003djp.1_Missense_Mutation_p.D219Y|DNASE1L3_uc003djq.1_Missense_Mutation_p.D219Y	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	219					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		TCCTCTTGGTCCCCGATCAGC	0.572	Esophageal Squamous(96;1069 1424 4841 43466 52325)		NA											23	51					6.44725e-10	1.00291e-09	0.002299	1	0
OR5K3	403277	broad.mit.edu	37	3	98109910	98109910	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:98109910C>A	uc011bgw.1	+	1	401	c.401C>A	c.(400-402)ACC>AAC	p.T134N		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAGTACCACACCATGATGTCC	0.468			NA											54	138					5.57489e-27	1.07435e-26	0.00361	1	0
ABI3BP	25890	broad.mit.edu	37	3	100604424	100604424	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:100604424C>A	uc003dun.2	-	6	758	c.673G>T	c.(673-675)GTA>TTA	p.V225L	ABI3BP_uc003duo.2_Missense_Mutation_p.V218L|ABI3BP_uc003dup.3_Missense_Mutation_p.V218L	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	225						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TTCCCATTTACTTTTTTACCT	0.303			NA											6	8					0.00198382	0.00247198	0.001984	1	0
SENP7	57337	broad.mit.edu	37	3	101090930	101090930	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:101090930T>G	uc003dut.2	-	7	829	c.718A>C	c.(718-720)AAG>CAG	p.K240Q	SENP7_uc003duu.2_Missense_Mutation_p.K175Q|SENP7_uc003duv.2_Missense_Mutation_p.K207Q|SENP7_uc003duw.2_Missense_Mutation_p.K174Q|SENP7_uc003dux.2_Missense_Mutation_p.K76Q	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	240					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						GCAGTCTGCTTTGCAGAATTG	0.373			NA											5	127					0	0	0.001168	0	0
BOC	91653	broad.mit.edu	37	3	113002297	113002297	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:113002297C>A	uc003dzx.2	+	16	3092	c.2471C>A	c.(2470-2472)CCA>CAA	p.P824Q	BOC_uc003dzy.2_Missense_Mutation_p.P824Q|BOC_uc003dzz.2_Missense_Mutation_p.P825Q|BOC_uc003eab.2_Missense_Mutation_p.P525Q|BOC_uc003eac.2_Missense_Mutation_p.P139Q	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	824	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			CTGCCACCCCCAACTCTGGCC	0.557			NA											66	164					1.37693e-34	2.76549e-34	0.00361	1	0
WDR52	55779	broad.mit.edu	37	3	113119471	113119471	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:113119471G>T	uc003eae.1	-	12	1441	c.1395C>A	c.(1393-1395)CTC>CTA	p.L465L		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	465										central_nervous_system(1)	1						GGAAGGAGAAGAGGCATTCTG	0.408			NA											7	77					0.00307968	0.00379774	0.00308	1	0
MYLK	4638	broad.mit.edu	37	3	123458825	123458825	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:123458825G>A	uc003ego.2	-	6	679	c.397C>T	c.(397-399)CAG>TAG	p.Q133*	MYLK_uc011bjw.1_Nonsense_Mutation_p.Q133*|MYLK_uc003egp.2_Nonsense_Mutation_p.Q133*|MYLK_uc003egq.2_Nonsense_Mutation_p.Q133*|MYLK_uc003egr.2_Nonsense_Mutation_p.Q133*|MYLK_uc003egs.2_5'UTR|MYLK_uc010hrs.1_Nonsense_Mutation_p.Q133*	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	133			Q -> H.		aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACAACAGGCTGACCAAGCTGC	0.463			NA											6	241					0	0	0.001168	0	0
UMPS	7372	broad.mit.edu	37	3	124462773	124462773	+	Missense_Mutation	SNP	G	G	A	rs121917891		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:124462773G>A	uc003ehl.3	+	6	1391	c.1285G>A	c.(1285-1287)GGC>AGC	p.G429S	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Missense_Mutation_p.G251S|UMPS_uc011bkb.1_Missense_Mutation_p.G337S|UMPS_uc011bkc.1_Missense_Mutation_p.G251S|UMPS_uc003ehn.3_Missense_Mutation_p.G251S|UMPS_uc011bkd.1_Missense_Mutation_p.G154S	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	429	OMPdecase.		G -> R (in ORAC1).		'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		AGATAATCTTGGCCAACAGTA	0.398			NA											28	59					0	0	0.001786	0	0
MSL2	55167	broad.mit.edu	37	3	135870109	135870109	+	Missense_Mutation	SNP	G	G	T	rs138536154	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:135870109G>T	uc003eqx.1	-	2	2347	c.1614C>A	c.(1612-1614)AAC>AAA	p.N538K	MSL2_uc011bmb.1_Missense_Mutation_p.N464K	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	538					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						TGGTACTAGCGTTACGCACAG	0.483			NA											7	79					8.12818e-05	0.000105711	0.001984	1	0
CRYGS	1427	broad.mit.edu	37	3	186257351	186257351	+	Silent	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:186257351A>T	uc003fqe.2	-	2	109	c.57T>A	c.(55-57)CGT>CGA	p.R19R	CRYGS_uc003fqf.2_Silent_p.R19R	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	19	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		AGTCATAGCGACGGCCTTGAA	0.443			NA											24	40					0	0	0.003954	0	0
BCL6	604	broad.mit.edu	37	3	187447128	187447128	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr3:187447128G>T	uc003frp.3	-	5	1522	c.1065C>A	c.(1063-1065)ATC>ATA	p.I355I	BCL6_uc011bsf.1_Silent_p.I355I|BCL6_uc010hza.2_Silent_p.I253I|BCL6_uc003frq.1_Silent_p.I355I	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	355					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		AAGCCTGGAGGATGCAGGCAT	0.572			NA	T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								27	208					7.41945e-09	1.11409e-08	0.005443	1	0
SORCS2	57537	broad.mit.edu	37	4	7728606	7728606	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:7728606G>C	uc003gkb.3	+	21	2845	c.2845G>C	c.(2845-2847)GAC>CAC	p.D949H	SORCS2_uc011bwi.1_Missense_Mutation_p.D777H	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	949	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GGTGCTGCAGGACTCCAGGGT	0.632			NA											21	34					0	0	0.001216	0	0
N4BP2	55728	broad.mit.edu	37	4	40104287	40104287	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:40104287C>T	uc003guy.3	+	4	1160	c.822C>T	c.(820-822)TGC>TGT	p.C274C	N4BP2_uc010ifq.2_Silent_p.C194C|N4BP2_uc010ifr.2_Silent_p.C194C	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	274						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AATCTGAGTGCGTTGAGGCTC	0.433			NA											19	92					0	0	0.007413	0	0
REST	5978	broad.mit.edu	37	4	57777171	57777171	+	Missense_Mutation	SNP	C	C	G	rs149829250	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:57777171C>G	uc003hch.2	+	2	714	c.367C>G	c.(367-369)CCT>GCT	p.P123A	REST_uc003hci.2_Missense_Mutation_p.P123A|REST_uc003hcj.1_Missense_Mutation_p.P123A|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	123					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					AGAACCTCAGCCTGTATTTGA	0.463			NA											18	60					0	0	0.001216	0	0
LPHN3	23284	broad.mit.edu	37	4	62778453	62778453	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:62778453G>A	uc010ihh.2	+	10	2059	c.1886G>A	c.(1885-1887)CGC>CAC	p.R629H	LPHN3_uc003hcq.3_Missense_Mutation_p.R629H|LPHN3_uc003hct.2_Intron|LPHN3_uc003hcs.1_Intron	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AAAAGAGAGCGCTCTTGCAGA	0.363			NA											23	92					0	0	0.002299	0	0
TECRL	253017	broad.mit.edu	37	4	65147240	65147240	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:65147240G>T	uc003hcv.2	-	10	979	c.870C>A	c.(868-870)CCC>CCA	p.P290P	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	290					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TCCATGTGAAGGGGTTATAAT	0.328			NA											18	46					1.15919e-05	1.54126e-05	0.001216	1	0
MUC7	4589	broad.mit.edu	37	4	71347156	71347156	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:71347156C>A	uc011cat.1	+	4	983	c.695C>A	c.(694-696)CCA>CAA	p.P232Q	MUC7_uc011cau.1_Missense_Mutation_p.P232Q|MUC7_uc003hfj.2_Missense_Mutation_p.P232Q|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	232	3.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TCAGCTCCACCAGAGACCACA	0.587			NA											66	114					1.63498e-16	2.81975e-16	0.00361	1	0
PDHA2	5161	broad.mit.edu	37	4	96762444	96762444	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:96762444G>T	uc003htr.3	+	1	1206	c.1143G>T	c.(1141-1143)TGG>TGT	p.W381C		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	381					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CAAATCCATGGATCAAGTTTA	0.413			NA											13	90					4.3838e-07	6.10143e-07	0.001855	1	0
FAT4	79633	broad.mit.edu	37	4	126372404	126372404	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:126372404G>T	uc003ifj.3	+	9	10233	c.10233G>T	c.(10231-10233)GTG>GTT	p.V3411V	FAT4_uc011cgp.1_Silent_p.V1709V|FAT4_uc003ifi.1_Silent_p.V889V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3411	Cadherin 33.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTACAGTGTGCAGATCAGTG	0.463			NA											14	192					4.36969e-10	6.81958e-10	0.001855	1	0
PCDH10	57575	broad.mit.edu	37	4	134071514	134071514	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:134071514G>T	uc003iha.2	+	1	1045	c.219G>T	c.(217-219)CTG>CTT	p.L73L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.L73L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	73	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CAGGGGTGCTGTACGTGAACG	0.542			NA											7	112					0.00307968	0.00379774	0.00308	1	0
TIGD4	201798	broad.mit.edu	37	4	153691222	153691222	+	Missense_Mutation	SNP	G	G	A	rs149761550	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:153691222G>A	uc003imy.2	-	2	1717	c.935C>T	c.(934-936)TCT>TTT	p.S312F		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	312	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ACATTTGGAAGATAAACATGA	0.348			NA											49	81					0	0	0.00361	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5200305	5200305	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:5200305G>A	uc003jdl.2	+	9	1512	c.1374G>A	c.(1372-1374)ATG>ATA	p.M458I	ADAMTS16_uc003jdk.1_Missense_Mutation_p.M458I|ADAMTS16_uc003jdj.1_Missense_Mutation_p.M458I	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	458	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GCAACATCATGTCCCCTACAT	0.423			NA											9	50					0	0	0.004482	0	0
CDH12	1010	broad.mit.edu	37	5	21975358	21975358	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:21975358G>A	uc010iuc.2	-	3	826	c.368C>T	c.(367-369)CCT>CTT	p.P123L	CDH12_uc011cno.1_Missense_Mutation_p.P123L|CDH12_uc003jgk.2_Missense_Mutation_p.P123L	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	123	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AGTGTAGAAAGGTTTCTCTTC	0.443			NA								HNSCC(59;0.17)			4	175					0	0	0.000248	0	0
CDH10	1008	broad.mit.edu	37	5	24537674	24537674	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:24537674G>T	uc003jgr.1	-	3	673	c.341C>A	c.(340-342)ACA>AAA	p.T114K	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	114	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AATTCGCCTTGTGGCATGAAT	0.408			NA								HNSCC(23;0.051)			26	118					4.22769e-11	6.66352e-11	0.00632	1	0
DNAJC21	134218	broad.mit.edu	37	5	34937468	34937468	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:34937468G>T	uc003jjc.2	+	5	703	c.476G>T	c.(475-477)TGC>TTC	p.C159F	DNAJC21_uc003jjb.2_Missense_Mutation_p.C159F|DNAJC21_uc010iuu.1_Missense_Mutation_p.C43F	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	159					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			CAGAGTTTCTGCACTCAAAAG	0.373			NA											28	33					2.2171e-23	4.15488e-23	0.001786	1	0
NUP155	9631	broad.mit.edu	37	5	37299057	37299057	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:37299057T>C	uc003jku.1	-	32	3824	c.3706A>G	c.(3706-3708)AGC>GGC	p.S1236G	NUP155_uc003jkt.1_Missense_Mutation_p.S1177G|NUP155_uc010iuz.1_Missense_Mutation_p.S1172G	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1236					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCCGAGGAGCTCAATGTCACA	0.368			NA											3	46					0	0	0.000602	0	0
EGFLAM	133584	broad.mit.edu	37	5	38458490	38458490	+	Missense_Mutation	SNP	C	C	A	rs139285515	byFrequency	TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:38458490C>A	uc003jlc.1	+	21	3113	c.2789C>A	c.(2788-2790)GCC>GAC	p.A930D	EGFLAM_uc003jlb.1_Missense_Mutation_p.A922D|EGFLAM_uc003jle.1_Missense_Mutation_p.A688D|EGFLAM_uc003jlf.1_Missense_Mutation_p.A288D|EGFLAM_uc003jlg.1_Missense_Mutation_p.A65D	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	930	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CGAGTTAAGGCCGTTAGGTGA	0.562	Colon(62;485 1295 3347 17454)		NA											18	66					1.15919e-05	1.54126e-05	0.001216	1	0
OSMR	9180	broad.mit.edu	37	5	38883971	38883971	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:38883971A>T	uc003jln.1	+	5	828	c.461A>T	c.(460-462)AAA>ATA	p.K154I	OSMR_uc003jlm.1_Missense_Mutation_p.K154I	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	154	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GTTTTCCCTAAAGATAAGCTG	0.348			NA											33	120					0	0	0.004289	0	0
DAB2	1601	broad.mit.edu	37	5	39383196	39383196	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:39383196T>A	uc003jlx.2	-	10	1396	c.865A>T	c.(865-867)ACC>TCC	p.T289S	DAB2_uc003jlw.2_Missense_Mutation_p.T268S	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	289					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GGATTAGGGGTGGGAAAGAAG	0.473			NA											47	160					0	0	0.00361	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855060	79855060	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:79855060C>A	uc010jam.2	-	4	1129	c.779G>T	c.(778-780)AGA>ATA	p.R260I	ANKRD34B_uc003kgw.2_Missense_Mutation_p.R260I|ANKRD34B_uc010jan.2_Missense_Mutation_p.R260I	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	260						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		TGAAGCCACTCTGTTCTGGTG	0.532			NA											31	90					4.4194e-11	6.94269e-11	0.002836	1	0
PCSK1	5122	broad.mit.edu	37	5	95764992	95764992	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:95764992G>C	uc003kls.1	-	2	416	c.210C>G	c.(208-210)TTC>TTG	p.F70L		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	70					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTTATGTTTGAATAAGTAGT	0.328			NA											5	103					0	0	0.000602	0	0
CSNK1G3	1456	broad.mit.edu	37	5	122909090	122909090	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:122909090G>T	uc003ktm.2	+	5	1012	c.293G>T	c.(292-294)GGT>GTT	p.G98V	CSNK1G3_uc003ktl.2_Missense_Mutation_p.G98V|CSNK1G3_uc003ktn.2_Missense_Mutation_p.G98V|CSNK1G3_uc003kto.2_Missense_Mutation_p.G98V|CSNK1G3_uc011cwr.1_Missense_Mutation_p.G23V|CSNK1G3_uc011cws.1_5'UTR|CSNK1G3_uc010jda.2_Missense_Mutation_p.G98V	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	98	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		CCCCCAGATGGTATACCTCAA	0.338	Pancreas(187;2868 2964 4353 6297)		NA											8	159					0.000274275	0.000348147	0.004482	1	0
FBN2	2201	broad.mit.edu	37	5	127713551	127713551	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:127713551C>G	uc003kuu.2	-	13	2182	c.1743G>C	c.(1741-1743)CAG>CAC	p.Q581H	FBN2_uc003kuv.2_Missense_Mutation_p.Q548H	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	581	EGF-like 8; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAACCCCATTCTGGATGCACT	0.358			NA											15	203					0	0	0.003163	0	0
FBN2	2201	broad.mit.edu	37	5	127713567	127713567	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:127713567A>T	uc003kuu.2	-	13	2166	c.1727T>A	c.(1726-1728)ATT>AAT	p.I576N	FBN2_uc003kuv.2_Missense_Mutation_p.I543N	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	576	EGF-like 8; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCACTCATCAATATCTAGGAA	0.348			NA											11	180					0	0	0.001855	0	0
ACSL6	23305	broad.mit.edu	37	5	131324551	131324551	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:131324551A>G	uc010jdo.1	-	6	607	c.524T>C	c.(523-525)GTC>GCC	p.V175A	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.V200A|ACSL6_uc003kvy.1_Missense_Mutation_p.V200A|ACSL6_uc003kwb.2_Missense_Mutation_p.V165A|ACSL6_uc003kvz.1_Missense_Mutation_p.V140A|ACSL6_uc003kwa.1_Missense_Mutation_p.V186A|ACSL6_uc010jdn.1_Missense_Mutation_p.V175A|ACSL6_uc010jdp.1_5'Flank	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	175	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATAGAGCGGGACCACCACCAT	0.587			NA											4	151					0	0	0.001168	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502877	140502877	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140502877C>A	uc003lip.1	+	1	1297	c.1297C>A	c.(1297-1299)CAG>AAG	p.Q433K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	433	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGAAAACCCAGCAGAACAT	0.582			NA											33	123					1.02151e-06	1.40531e-06	0.002836	1	0
PCDHB7	56129	broad.mit.edu	37	5	140554464	140554464	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140554464C>A	uc003lit.2	+	1	2222	c.2048C>A	c.(2047-2049)TCG>TAG	p.S683*	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	683	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGCCAACTCGCTCACCGTC	0.706			NA											39	80					2.05212e-20	3.7141e-20	0.005524	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140732045	140732045	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140732045A>T	uc003ljo.1	+	1	2218	c.2218A>T	c.(2218-2220)AGC>TGC	p.S740C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.S740C|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	740	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCAACCACAGCGAGGGGAC	0.562			NA											27	131					0	0	0.00632	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735712	140735712	+	Nonsense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140735712T>A	uc003ljq.1	+	1	945	c.945T>A	c.(943-945)TAT>TAA	p.Y315*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Nonsense_Mutation_p.Y315*	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	315	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGATTCTATGACATAGATG	0.438			NA											7	19					0	0	0.001984	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779378	140779378	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140779378G>A	uc003lkf.1	+	1	1684	c.1684G>A	c.(1684-1686)GCG>ACG	p.A562T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.A562T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	562	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTACCCCGCGCTGGGTCC	0.692			NA											5	34					0	0	0.001168	0	0
GNPDA1	10007	broad.mit.edu	37	5	141387389	141387389	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:141387389C>A	uc003lmf.3	-	2	960	c.201G>T	c.(199-201)AAG>AAT	p.K67N	GNPDA1_uc003lmg.3_Missense_Mutation_p.K67N|GNPDA1_uc010jgh.2_Missense_Mutation_p.K67N|GNPDA1_uc003lmh.3_Intron	NM_005471	NP_005462	P46926	GNPI1_HUMAN	glucosamine-6-phosphate deaminase 1	67					generation of precursor metabolites and energy|glucosamine catabolic process|N-acetylglucosamine metabolic process|single fertilization	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity				0		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTGAAGGTCTTCACATATT	0.478			NA											64	202					2.03652e-46	4.16045e-46	0.00361	1	0
PDE6A	5145	broad.mit.edu	37	5	149240474	149240474	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:149240474G>T	uc003lrg.3	-	22	2687	c.2567C>A	c.(2566-2568)TCC>TAC	p.S856Y		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	856					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GATGCAGCAGGACTTGGATGT	0.562			NA											9	24					1.08611e-07	1.5619e-07	0.000978	1	0
GABRA1	2554	broad.mit.edu	37	5	161317997	161317997	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:161317997T>A	uc010jiw.2	+	9	1265	c.797T>A	c.(796-798)ATT>AAT	p.I266N	GABRA1_uc010jix.2_Missense_Mutation_p.I266N|GABRA1_uc010jiy.2_Missense_Mutation_p.I266N|GABRA1_uc003lyx.3_Missense_Mutation_p.I266N|GABRA1_uc010jiz.2_Missense_Mutation_p.I266N|GABRA1_uc010jja.2_Missense_Mutation_p.I266N|GABRA1_uc010jjb.2_Missense_Mutation_p.I266N	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	266	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	ATGACAGTGATTCTCTCACAA	0.413			NA											5	113					0	0	0.000602	0	0
HMMR	3161	broad.mit.edu	37	5	162896811	162896811	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:162896811G>T	uc003lzf.2	+	5	617	c.435G>T	c.(433-435)AGG>AGT	p.R145S	HMMR_uc003lzh.2_Missense_Mutation_p.R146S|HMMR_uc003lzg.2_Missense_Mutation_p.R130S|HMMR_uc011dem.1_Missense_Mutation_p.R59S	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	145						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AATTGACCAGGACTAATGAAC	0.294			NA											19	22					3.85864e-22	7.14674e-22	0.00278	1	0
UIMC1	51720	broad.mit.edu	37	5	176332314	176332314	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:176332314T>A	uc011dfp.1	-	15	2296	c.2129A>T	c.(2128-2130)AAA>ATA	p.K710I	UIMC1_uc003mfc.1_Missense_Mutation_p.K587I|UIMC1_uc003mfd.1_Missense_Mutation_p.K340I	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	710					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGCCAGCTTTGGTCCGTGT	0.448			NA											9	95					0	0	0.001368	0	0
PRPF4B	8899	broad.mit.edu	37	6	4032758	4032758	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:4032758G>T	uc003mvv.2	+	2	1098	c.1007G>T	c.(1006-1008)GGG>GTG	p.G336V	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	336	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GCTTCATCTGGGAAAGAAAAT	0.408			NA											69	59					1.43987e-31	2.85574e-31	0.00361	1	0
F13A1	2162	broad.mit.edu	37	6	6196057	6196057	+	Silent	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:6196057T>C	uc003mwv.2	-	10	1401	c.1278A>G	c.(1276-1278)CAA>CAG	p.Q426Q	F13A1_uc011dib.1_Silent_p.Q363Q	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	426					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GTGCATCAAATTGGAAGCAGA	0.493			NA											4	76					0	0	0.000602	0	0
CDKAL1	54901	broad.mit.edu	37	6	21065370	21065370	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:21065370G>C	uc003ndc.1	+	12	1321	c.1147G>C	c.(1147-1149)GAG>CAG	p.E383Q	CDKAL1_uc003ndd.1_Missense_Mutation_p.E383Q|CDKAL1_uc003nde.1_Missense_Mutation_p.E313Q|CDKAL1_uc003ndf.1_5'UTR	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	383					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			ACTTGTTGAAGAGTACAAATT	0.373			NA											26	71					0	0	0.005443	0	0
TRIM10	10107	broad.mit.edu	37	6	30121946	30121946	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:30121946C>A	uc003npo.3	-	7	1322	c.1246G>T	c.(1246-1248)GGC>TGC	p.G416C	TRIM10_uc003npn.2_Intron	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	416	B30.2/SPRY.					cytoplasm	zinc ion binding				0						GGGAAGGAGCCCAGAGCCGAG	0.662			NA											22	19					1.33986e-20	2.44358e-20	0.004656	1	0
PGK2	5232	broad.mit.edu	37	6	49753968	49753968	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:49753968C>A	uc003ozu.2	-	1	1040	c.933G>T	c.(931-933)TGG>TGT	p.W311C		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	311					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					CCAAACCCATCCAGCCAGGAG	0.453			NA											111	122					8.62921e-31	1.69732e-30	0.00361	1	0
BEND6	221336	broad.mit.edu	37	6	56857338	56857338	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:56857338T>A	uc010kab.2	+	3	869	c.283T>A	c.(283-285)TTG>ATG	p.L95M	BEND6_uc003pdg.2_RNA	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	95	Potential.										0						TCGACAGTCTTTGGTCATGCT	0.353			NA											20	243					0	0	0.002299	0	0
BAI3	577	broad.mit.edu	37	6	69728293	69728293	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:69728293G>A	uc003pev.3	+	13	2457	c.2009G>A	c.(2008-2010)GGG>GAG	p.G670E	BAI3_uc010kak.2_Missense_Mutation_p.G670E	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	670	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATTTATCCAGGGTCAATAGAG	0.303			NA											7	108					0	0	0.00308	0	0
LMBRD1	55788	broad.mit.edu	37	6	70490434	70490434	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:70490434C>G	uc003pfa.2	-	3	374	c.259G>C	c.(259-261)GCT>CCT	p.A87P	LMBRD1_uc003pez.2_Missense_Mutation_p.A14P|LMBRD1_uc010kal.2_Missense_Mutation_p.A14P|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	87	Extracellular (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						CTGACATTAGCATTAGCCCAG	0.333			NA											38	32					0	0	0.001951	0	0
PTPRK	5796	broad.mit.edu	37	6	128294253	128294253	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:128294253C>T	uc003qbk.2	-	29	4547	c.4180G>A	c.(4180-4182)GAA>AAA	p.E1394K	PTPRK_uc003qbj.2_Missense_Mutation_p.E1395K|PTPRK_uc010kfc.2_Missense_Mutation_p.E1401K|PTPRK_uc011ebu.1_Missense_Mutation_p.E1417K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1394	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTCACCATTTCAACAACGATG	0.443			NA											30	167					0	0	0.00632	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135263563	135263563	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:135263563C>A	uc003qew.2	-	3	479	c.426G>T	c.(424-426)CGG>CGT	p.R142R	ALDH8A1_uc003qex.2_Silent_p.R142R|ALDH8A1_uc010kgh.2_5'UTR|ALDH8A1_uc011ecx.1_Silent_p.R142R	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	142					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		CCACCGGGGCCCGCACCGTGT	0.582			NA											27	40					1.50538e-07	2.15832e-07	0.00632	1	0
GRM1	2911	broad.mit.edu	37	6	146720434	146720434	+	Silent	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:146720434G>C	uc010khw.1	+	8	2729	c.2259G>C	c.(2257-2259)GTG>GTC	p.V753V	GRM1_uc010khv.1_Silent_p.V753V|GRM1_uc003qll.2_Silent_p.V753V|GRM1_uc011edz.1_Silent_p.V753V|GRM1_uc011eea.1_Silent_p.V753V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	753	Helical; Name=5; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACCTGGGTGTGGTGGCCCCTT	0.512			NA											52	84					0	0	0.00361	0	0
CLDN20	49861	broad.mit.edu	37	6	155597138	155597138	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:155597138C>G	uc003qql.1	+	2	665	c.285C>G	c.(283-285)ATC>ATG	p.I95M	TFB1M_uc003qqj.3_Intron|TFB1M_uc003qqk.2_Intron	NM_001001346	NP_001001346	P56880	CLD20_HUMAN	claudin 20	95	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0				OV - Ovarian serous cystadenocarcinoma(155;7.82e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0114)		CTTTGGGGATCTGCACTTCCA	0.542			NA											3	75					0	0	0.004672	0	0
T	6862	broad.mit.edu	37	6	166571970	166571970	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:166571970C>T	uc003quu.1	-	9	1634	c.1141G>A	c.(1141-1143)GCG>ACG	p.A381T	T_uc003qut.1_Missense_Mutation_p.A382T|T_uc003quv.1_Missense_Mutation_p.A323T	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	381					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTGTAGTGCGCGGGGGAGCCC	0.711			NA							Chordoma_Familial_Clustering_of				4	53					0	0	0.000248	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166872949	166872949	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:166872949G>A	uc003qvb.1	-	12	1282	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	RPS6KA2_uc011ego.1_Missense_Mutation_p.R266W|RPS6KA2_uc010kkl.1_Missense_Mutation_p.R266W|RPS6KA2_uc003qvc.1_Missense_Mutation_p.R363W|RPS6KA2_uc003qvd.1_Missense_Mutation_p.R380W	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	355	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GTGGGCGTCCGCGCTGTGAAC	0.552			NA											4	20					0	0	0.000248	0	0
COX19	90639	broad.mit.edu	37	7	1012907	1012907	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:1012907T>C	uc003sjp.1	-	2	194	c.104A>G	c.(103-105)GAG>GGG	p.E35G	ADAP1_uc010ksc.2_5'UTR	NM_001031617	NP_001026788	Q49B96	COX19_HUMAN	COX19 cytochrome c oxidase assembly homolog	35	CHCH.					cytosol					0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;2.15e-15)		CATGAATTTCTCTTTAAAGCT	0.363			NA											8	64					0	0	0.00308	0	0
COL28A1	340267	broad.mit.edu	37	7	7480482	7480482	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:7480482C>A	uc003src.1	-	21	1778	c.1661G>T	c.(1660-1662)GGC>GTC	p.G554V	COL28A1_uc011jxe.1_Missense_Mutation_p.G237V|COL28A1_uc003srd.2_Missense_Mutation_p.G109V	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	554	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCCTTTCTTGCCTTCGTCACC	0.443			NA											15	50					4.7546e-09	7.25382e-09	0.004007	1	0
GLCCI1	113263	broad.mit.edu	37	7	8110750	8110750	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:8110750A>T	uc003srk.2	+	6	1725	c.1166A>T	c.(1165-1167)GAT>GTT	p.D389V		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	389											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TTGCTCTATGATCGTGATAAA	0.443			NA											19	88					0	0	0.001216	0	0
TWIST1	7291	broad.mit.edu	37	7	19156565	19156565	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:19156565G>A	uc003sum.2	-	1	731	c.380C>T	c.(379-381)GCG>GTG	p.A127V		NM_000474	NP_000465	Q15672	TWST1_HUMAN	twist	127	Helix-loop-helix motif.				aortic valve morphogenesis|cellular response to hypoxia|embryonic camera-type eye formation|embryonic cranial skeleton morphogenesis|eyelid development in camera-type eye|muscle organ development|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of histone phosphorylation|negative regulation of osteoblast differentiation|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of cell motility|positive regulation of epithelial to mesenchymal transition|positive regulation of fatty acid beta-oxidation|positive regulation of monocyte chemotactic protein-1 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of tumor necrosis factor production|regulation of bone mineralization	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding RNA polymerase II transcription factor activity				0						CGCGGCGAACGCCTCGTTCAG	0.597			NA							Saethre-Chotzen_syndrome				4	25					0	0	0.000602	0	0
PDE1C	5137	broad.mit.edu	37	7	31917643	31917643	+	Silent	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:31917643A>G	uc003tcm.1	-	5	901	c.432T>C	c.(430-432)TAT>TAC	p.Y144Y	PDE1C_uc003tcn.1_Silent_p.Y144Y|PDE1C_uc003tco.1_Silent_p.Y204Y|PDE1C_uc003tcr.2_Silent_p.Y144Y|PDE1C_uc003tcs.2_Silent_p.Y144Y	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	144					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			ATGTCCGTCTATACATTCTGA	0.348			NA											26	28					0	0	0.00632	0	0
VPS41	27072	broad.mit.edu	37	7	38783118	38783118	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:38783118G>A	uc003tgy.2	-	24	2032	c.2006C>T	c.(2005-2007)GCC>GTC	p.A669V	VPS41_uc003tgz.2_Missense_Mutation_p.A644V|VPS41_uc010kxn.2_Missense_Mutation_p.A580V|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	669	Clathrin.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CATCTTCAGGGCACTTCGGCT	0.368			NA											4	103					0	0	0.000602	0	0
ABCA13	154664	broad.mit.edu	37	7	48314884	48314884	+	Nonsense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:48314884C>G	uc003toq.2	+	17	5646	c.5621C>G	c.(5620-5622)TCA>TGA	p.S1874*	ABCA13_uc010kyr.2_Nonsense_Mutation_p.S1377*	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1874					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCACCATGTTCAAATGAAAGC	0.423			NA											9	69					0	0	0.006214	0	0
GBAS	2631	broad.mit.edu	37	7	56049250	56049250	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:56049250G>T	uc003tre.1	+	4	371	c.363G>T	c.(361-363)CAG>CAT	p.Q121H	GBAS_uc003trf.1_Missense_Mutation_p.R106M	NM_001483	NP_001474	O75323	NIPS2_HUMAN	nipsnap homolog 2	121						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			central_nervous_system(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATGGCGAGCAGGACCAAGCTG	0.398			NA											43	98					8.69298e-16	1.48844e-15	0.006999	1	0
CLDN4	1364	broad.mit.edu	37	7	73245707	73245707	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:73245707C>T	uc003tzi.3	+	1	515	c.176C>T	c.(175-177)ACC>ATC	p.T59I	RFC2_uc011kfa.1_Intron|CLDN4_uc003tzh.1_RNA	NM_001305	NP_001296	O14493	CLD4_HUMAN	claudin 4	59	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				GTGCAGAGCACCGGCCAGATG	0.642			NA											10	47					0	0	0.000978	0	0
SAMD9	54809	broad.mit.edu	37	7	92730825	92730825	+	Missense_Mutation	SNP	C	C	A	rs149966534		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:92730825C>A	uc003umf.2	-	3	4842	c.4586G>T	c.(4585-4587)CGT>CTT	p.R1529L	SAMD9_uc003umg.2_Missense_Mutation_p.R1529L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1529						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ACCTTGTAAACGAAGCAAAAG	0.368			NA											19	60					3.32936e-07	4.67485e-07	0.006122	1	0
DLX5	1749	broad.mit.edu	37	7	96650227	96650227	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:96650227G>T	uc003uon.2	-	3	899	c.691C>A	c.(691-693)CGC>AGC	p.R231S		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	231					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					CTGAGCGAGCGGGACGAGCCC	0.657			NA											15	30					6.81908e-15	1.15924e-14	0.00245	1	0
TRRAP	8295	broad.mit.edu	37	7	98592340	98592340	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:98592340G>T	uc003upp.2	+	66	10345	c.10136G>T	c.(10135-10137)GGG>GTG	p.G3379V	TRRAP_uc011kis.1_Missense_Mutation_p.G3350V|TRRAP_uc003upr.2_Missense_Mutation_p.G3085V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3379					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCACGTTTGGGGTGGGCCTG	0.562			NA											60	167					2.50483e-33	5.00965e-33	0.00361	1	0
STAG3	10734	broad.mit.edu	37	7	99809101	99809101	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:99809101C>A	uc003utx.1	+	31	3609	c.3454C>A	c.(3454-3456)CCA>ACA	p.P1152T	STAG3_uc011kjk.1_Missense_Mutation_p.P1094T|GATS_uc003uty.3_RNA|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|STAG3_uc003uub.1_Missense_Mutation_p.P377T|GATS_uc011kjl.1_RNA|GATS_uc010lgu.2_RNA	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1152					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTTCTTGGGTCCACAATATTT	0.507			NA											33	121					9.80977e-26	1.88284e-25	0.004289	1	0
MUC17	140453	broad.mit.edu	37	7	100683794	100683794	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:100683794G>T	uc003uxp.1	+	3	9150	c.9097G>T	c.(9097-9099)GGT>TGT	p.G3033C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3033	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|49.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTGCTGAAGGTACCGGCAT	0.522			NA											13	573					1.05317e-09	1.62763e-09	0.00245	1	0
MUC17	140453	broad.mit.edu	37	7	100684511	100684511	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:100684511C>T	uc003uxp.1	+	3	9867	c.9814C>T	c.(9814-9816)CCA>TCA	p.P3272S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3272	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.502			NA											6	648					0	0	0.001168	0	0
SLC26A5	375611	broad.mit.edu	37	7	103018234	103018234	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:103018234C>T	uc003vbz.2	-	18	2034	c.1798G>A	c.(1798-1800)GAT>AAT	p.D600N	SLC26A5_uc003vbt.1_Missense_Mutation_p.D600N|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.D568N|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	600	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TCCTCTCCATCTACTTCTGCA	0.363			NA											21	72					0	0	0.002299	0	0
RELN	5649	broad.mit.edu	37	7	103206713	103206713	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:103206713A>T	uc003vca.2	-	33	5054	c.4894T>A	c.(4894-4896)TGT>AGT	p.C1632S	RELN_uc010liz.2_Missense_Mutation_p.C1632S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1632					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATAGAGAGACAGTCAATATCA	0.363	NSCLC(146;835 1944 15585 22231 52158)		NA											15	58					0	0	0.006122	0	0
PUS7	54517	broad.mit.edu	37	7	105108805	105108805	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:105108805C>T	uc003vcx.2	-	12	1723	c.1504G>A	c.(1504-1506)GGG>AGG	p.G502R	PUS7_uc010lji.2_Missense_Mutation_p.G508R|PUS7_uc003vcy.2_Missense_Mutation_p.G502R|PUS7_uc003vcz.1_Missense_Mutation_p.G502R	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	502	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						ACGAGGTCCCCTGGAACAGGT	0.408	Colon(138;2387 3051 17860)		NA											52	183					0	0	0.00361	0	0
EIF3IP1	442720	broad.mit.edu	37	7	109599684	109599684	+	Silent	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:109599684G>T	uc003vfp.1	-	1	587	c.414C>A	c.(412-414)TCC>TCA	p.S138S		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						TAATCTGCTAGGAGTGCTCCT	0.478			NA											11	43					2.27111e-07	3.20786e-07	0.001368	1	0
ARF5	381	broad.mit.edu	37	7	127231284	127231284	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:127231284C>T	uc003vmb.1	+	6	510	c.474C>T	c.(472-474)ACC>ACT	p.T158T	FSCN3_uc003vmc.1_5'Flank|FSCN3_uc011kog.1_5'Flank|FSCN3_uc011koh.1_5'Flank|FSCN3_uc003vmd.1_5'Flank|FSCN3_uc010llc.1_5'Flank	NM_001662	NP_001653	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	158					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1						TCCAGGCCACCTGTGCCACCC	0.572			NA											13	25					0	0	0.00245	0	0
KLHDC10	23008	broad.mit.edu	37	7	129765721	129765721	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:129765721T>A	uc003vpj.1	+	7	1016	c.881T>A	c.(880-882)CTT>CAT	p.L294H	KLHDC10_uc003vpk.1_Missense_Mutation_p.L265H|KLHDC10_uc010lmb.1_Missense_Mutation_p.L191H	NM_014997	NP_055812	Q6PID8	KLD10_HUMAN	kelch domain containing 10	294	Kelch 4.										0						GCATACAACCTTGAAACGAAT	0.264			NA											12	48					0	0	0.00245	0	0
CPA2	1358	broad.mit.edu	37	7	129916550	129916550	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:129916550C>A	uc003vpq.2	+	7	687	c.668C>A	c.(667-669)CCT>CAT	p.P223H	CPA2_uc011kpc.1_Missense_Mutation_p.P223H	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	223					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GTCACAAACCCTGATGGATAC	0.423			NA											30	93					5.60225e-13	9.10126e-13	0.001786	1	0
MGAM	8972	broad.mit.edu	37	7	141738391	141738391	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:141738391C>A	uc003vwy.2	+	19	2346	c.2292C>A	c.(2290-2292)CTC>CTA	p.L764L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	764	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGCCCGGCCTCCTCATCACTC	0.498			NA											8	22					0.00307968	0.00379774	0.00308	1	0
TRPV6	55503	broad.mit.edu	37	7	142575519	142575519	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:142575519C>A	uc003wbx.1	-	3	450	c.234G>T	c.(232-234)ATG>ATT	p.M78I	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	78	Cytoplasmic (Potential).|ANK 2.				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CTGTTTCCCCCATGGCTCCTG	0.572			NA											32	98					1.61788e-16	2.8004e-16	0.002445	1	0
CLCN1	1180	broad.mit.edu	37	7	143043748	143043748	+	Silent	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:143043748C>A	uc003wcr.1	+	19	2448	c.2361C>A	c.(2359-2361)ACC>ACA	p.T787T	CLCN1_uc011ktc.1_Silent_p.T399T	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	787	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					AGAAAACAACCCAGGTGAGAG	0.547			NA											26	93					1.32003e-05	1.73573e-05	0.005443	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146997239	146997239	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:146997239G>C	uc003weu.1	+	9	1871	c.1355G>C	c.(1354-1356)GGG>GCG	p.G452A		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	452	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCAGGTTCTGGGTTGAATGAT	0.373			NA								HNSCC(39;0.1)			3	73					0	0	0.004672	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417162	150417162	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:150417162C>A	uc003whq.2	+	3	157	c.70C>A	c.(70-72)CAG>AAG	p.Q24K	GIMAP1_uc003whp.2_Missense_Mutation_p.Q32K	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	24	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCAGTCCCGGCAGGAGTCCAC	0.532			NA											82	219					5.10314e-47	1.04702e-46	0.00361	1	0
RP1L1	94137	broad.mit.edu	37	8	10465877	10465877	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:10465877C>A	uc003wtc.2	-	4	5960	c.5731G>T	c.(5731-5733)GCA>TCA	p.A1911S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1911					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCTTTTCTGCCTCCGGGGCT	0.597			NA											8	268					0.000157383	0.000201383	0.00308	1	0
ADAM28	10863	broad.mit.edu	37	8	24184143	24184143	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:24184143G>A	uc003xdy.2	+	10	1050	c.967G>A	c.(967-969)GTT>ATT	p.V323I	ADAM28_uc003xdx.2_Missense_Mutation_p.V323I|ADAM28_uc011kzz.1_Missense_Mutation_p.V90I|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Missense_Mutation_p.V10I	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	323	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGTTGGCGTTGTTCAGGTCTG	0.279	NSCLC(193;488 2149 22258 34798 40734)		NA											101	95					0	0	0.00361	0	0
KIAA0146	23514	broad.mit.edu	37	8	48309124	48309124	+	Silent	SNP	T	T	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:48309124T>A	uc003xqd.2	+	6	723	c.714T>A	c.(712-714)CCT>CCA	p.P238P	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Silent_p.P238P|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Silent_p.P168P|KIAA0146_uc011ldd.1_Silent_p.P178P|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	238											0		Lung NSC(58;0.175)				TGCATACACCTCAGAAACCCA	0.373			NA											11	474					0	0	0.001855	0	0
CEBPD	1052	broad.mit.edu	37	8	48650524	48650524	+	Silent	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:48650524G>A	uc003xqh.1	-	1	203	c.159C>T	c.(157-159)TAC>TAT	p.Y53Y	KIAA0146_uc003xqg.1_Intron	NM_005195	NP_005186	P49716	CEBPD_HUMAN	CCAAT/enhancer binding protein delta	53					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(86;0.0782)|Lung NSC(58;0.00363)|all_epithelial(80;0.0042)|all_lung(54;0.00914)				TCTCGTCGTCGTACATGGCGG	0.726	GBM(26;131 685 21356 28665)		NA											4	61					0	0	0.000602	0	0
NSMAF	8439	broad.mit.edu	37	8	59511849	59511849	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:59511849C>G	uc003xtt.2	-	19	1741	c.1527G>C	c.(1525-1527)TGG>TGC	p.W509C	NSMAF_uc011lee.1_Missense_Mutation_p.W540C	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	509	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TTAGATCAATCCACTCGTGAA	0.373			NA											36	336					0	0	0.005524	0	0
CSPP1	79848	broad.mit.edu	37	8	68031019	68031019	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:68031019A>G	uc003xxi.2	+	15	1781	c.1750A>G	c.(1750-1752)AGT>GGT	p.S584G	CSPP1_uc003xxg.1_Missense_Mutation_p.S576G|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.S549G|CSPP1_uc003xxk.2_Missense_Mutation_p.S255G	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	584						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGCTTATGTTAGTGCTCCTGT	0.279			NA											11	97					0	0	0.003163	0	0
EYA1	2138	broad.mit.edu	37	8	72156924	72156924	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:72156924G>T	uc003xys.3	-	11	1341	c.1054C>A	c.(1054-1056)CCA>ACA	p.P352T	EYA1_uc003xyr.3_Intron|EYA1_uc003xyt.3_Missense_Mutation_p.P319T|EYA1_uc010lzf.2_Missense_Mutation_p.P279T|EYA1_uc003xyu.2_Missense_Mutation_p.P352T|EYA1_uc011lfe.1_Missense_Mutation_p.P346T|EYA1_uc003xyv.2_Missense_Mutation_p.P230T	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	352					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GAAGTGGGTGGATCCTAAAAT	0.373			NA											13	37					7.03913e-09	1.06032e-08	0.001368	1	0
PI15	51050	broad.mit.edu	37	8	75757410	75757410	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:75757410A>C	uc003yal.2	+	4	619	c.440A>C	c.(439-441)AAA>ACA	p.K147T	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.K147T	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	147						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GATGAAGTGAAAGATTATGCT	0.398			NA											9	309					0	0	0.004482	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766034	77766034	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:77766034G>T	uc003yav.2	+	10	7129	c.6742G>T	c.(6742-6744)GAT>TAT	p.D2248Y	ZFHX4_uc003yau.1_Missense_Mutation_p.D2293Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.D2248Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2248						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGAAACAAAAGATAATGAAAA	0.408			NA								HNSCC(33;0.089)			31	54					8.58068e-18	1.50716e-17	0.007291	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766282	77766282	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:77766282C>A	uc003yav.2	+	10	7377	c.6990C>A	c.(6988-6990)AAC>AAA	p.N2330K	ZFHX4_uc003yau.1_Missense_Mutation_p.N2375K|ZFHX4_uc003yaw.1_Missense_Mutation_p.N2330K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2330						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.N2359N(1)		ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGCTAAAAACGCTGCTGCCC	0.507			NA								HNSCC(33;0.089)			85	196					1.8615e-32	3.70742e-32	0.00361	1	0
ODF1	4956	broad.mit.edu	37	8	103572936	103572936	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:103572936G>T	uc003ykt.2	+	2	685	c.577G>T	c.(577-579)GGC>TGC	p.G193C		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	193					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CTATGGGCTCGGCAGCTGTGT	0.368			NA											21	84					1.2644e-06	1.73446e-06	0.001523	1	0
RIMS2	9699	broad.mit.edu	37	8	104973292	104973292	+	Splice_Site	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:104973292G>C	uc003yls.2	+	13	2277	c.2036_splice	c.e13-1	p.R679_splice	RIMS2_uc003ylp.2_Splice_Site_p.R901_splice|RIMS2_uc003ylw.2_Splice_Site_p.R693_splice|RIMS2_uc003ylq.2_Splice_Site_p.R693_splice|RIMS2_uc003ylr.2_Splice_Site_p.R740_splice|RIMS2_uc003ylt.2_Splice_Site_p.R286_splice	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2						intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTACTTTATAGGGTCAAAGAG	0.294			NA								HNSCC(12;0.0054)			92	262					0	0	0.00361	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110523010	110523010	+	Silent	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:110523010A>T	uc003yne.2	+	71	11504	c.11400A>T	c.(11398-11400)CCA>CCT	p.P3800P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3800	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTAGGCCCACAGGATCATG	0.373			NA								HNSCC(38;0.096)			38	487					0	0	0.002852	0	0
HAS2	3037	broad.mit.edu	37	8	122641478	122641478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:122641478G>A	uc003yph.2	-	2	641	c.103C>T	c.(103-105)CAG>TAG	p.Q35*		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	35	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGATAAACTGGTAGCCAACA	0.418			NA											8	149					0	0	0.00308	0	0
FER1L6	654463	broad.mit.edu	37	8	124992922	124992922	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:124992922G>T	uc003yqw.2	+	11	1487	c.1281G>T	c.(1279-1281)AAG>AAT	p.K427N		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	427	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGCCTTCCAAGGACAAAGACT	0.458			NA									OREG0018964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	200					2.80697e-09	4.29621e-09	0.000978	1	0
CYP11B2	1585	broad.mit.edu	37	8	143996605	143996605	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:143996605G>T	uc003yxk.1	-	3	455	c.452C>A	c.(451-453)CCC>CAC	p.P151H		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	151					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CACGGCCTTGGGCGACAGCAC	0.637			NA							Familial_Hyperaldosteronism_type_I				34	41					1.36615e-20	2.48201e-20	0.002836	1	0
SCRIB	23513	broad.mit.edu	37	8	144876106	144876106	+	Silent	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:144876106C>T	uc003yzp.1	-	28	3880	c.3873G>A	c.(3871-3873)AAG>AAA	p.K1291K	SCRIB_uc003yzn.1_5'UTR|SCRIB_uc003yzo.1_Silent_p.K1291K	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1291					activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ATTCAGCCATCTTCCCTCCAG	0.662	Pancreas(51;966 1133 10533 14576 29674)		NA											7	80					0	0	0.00308	0	0
CYC1	1537	broad.mit.edu	37	8	145151255	145151255	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:145151255G>A	uc003zaz.3	+	4	512	c.469G>A	c.(469-471)GGC>AGC	p.G157S	CYC1_uc003zay.2_Missense_Mutation_p.G98S	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	157	Cytochrome c.				respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTTCAAGACGGCCCCAATGA	0.587			NA									OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	283					0	0	0.005524	0	0
MAF1	84232	broad.mit.edu	37	8	145161786	145161786	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:145161786G>C	uc003zbc.1	+	7	1170	c.669G>C	c.(667-669)GAG>GAC	p.E223D	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank|KIAA1875_uc011lky.1_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	223					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGACATGGAGCTGGGGGAGG	0.637			NA											4	48					0	0	0.000248	0	0
SMARCA2	6595	broad.mit.edu	37	9	2047450	2047450	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:2047450G>T	uc003zhc.2	+	5	1111	c.1012G>T	c.(1012-1014)GAC>TAC	p.D338Y	SMARCA2_uc003zhd.2_Missense_Mutation_p.D338Y|SMARCA2_uc010mha.2_Missense_Mutation_p.D329Y	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	338					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAAGGCCTGGACCCCGTGGA	0.697			NA											9	18					1.76689e-08	2.63649e-08	0.006214	1	0
FREM1	158326	broad.mit.edu	37	9	14846066	14846066	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:14846066A>T	uc003zlm.2	-	8	1875	c.1285T>A	c.(1285-1287)TCT>ACT	p.S429T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	429	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGGCTCGAGACTGCCCCTCA	0.408			NA											6	11					0	0	0.001168	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18905849	18905849	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:18905849G>A	uc003zne.3	+	27	5048	c.4921G>A	c.(4921-4923)GGC>AGC	p.G1641S	ADAMTSL1_uc003znf.3_Missense_Mutation_p.G342S|ADAMTSL1_uc003zng.1_Missense_Mutation_p.G32S	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1641						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GACACGGGATGGCATCACCTT	0.527			NA											9	16					0	0	0.000673	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396338	38396338	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:38396338C>A	uc004aay.2	+	2	705	c.593C>A	c.(592-594)CCG>CAG	p.P198Q		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	198					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AAACTTGCCCCGGCACTCGCC	0.597			NA											28	72					1.39806e-14	2.35984e-14	0.001512	1	0
C9orf71	169693	broad.mit.edu	37	9	71152351	71152351	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:71152351G>T	uc004agt.2	-	2	390	c.337C>A	c.(337-339)CCT>ACT	p.P113T	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	113						integral to membrane					0						CTCTCTGCAGGACAGCTCTGC	0.527			NA											15	60					1.99824e-07	2.84779e-07	0.00499	1	0
APBA1	320	broad.mit.edu	37	9	72130971	72130971	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:72130971T>C	uc004ahh.2	-	2	1432	c.1156A>G	c.(1156-1158)AGC>GGC	p.S386G		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	386	LIN-2/CASK binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						CTGGTGGGGCTAATGTCCTGG	0.622			NA											3	136					0	0	0.000248	0	0
TRPM3	80036	broad.mit.edu	37	9	73399097	73399097	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:73399097G>C	uc004aid.2	-	7	1316	c.1072C>G	c.(1072-1074)CCA>GCA	p.P358A	TRPM3_uc004ahu.2_Missense_Mutation_p.P188A|TRPM3_uc004ahv.2_Missense_Mutation_p.P188A|TRPM3_uc004ahw.2_Missense_Mutation_p.P230A|TRPM3_uc004ahx.2_Missense_Mutation_p.P205A|TRPM3_uc004ahy.2_Missense_Mutation_p.P230A|TRPM3_uc004ahz.2_Missense_Mutation_p.P205A|TRPM3_uc004aia.2_Missense_Mutation_p.P205A|TRPM3_uc004aib.2_Missense_Mutation_p.P205A|TRPM3_uc004aic.2_Missense_Mutation_p.P358A|TRPM3_uc010mor.2_Missense_Mutation_p.P358A|TRPM3_uc004aie.2_Missense_Mutation_p.P205A|TRPM3_uc004aif.2_Missense_Mutation_p.P230A|TRPM3_uc004aig.2_Missense_Mutation_p.P205A	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	383	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ACAACCACTGGCACGGGAGGG	0.542			NA											20	74					0	0	0.001216	0	0
TRPM6	140803	broad.mit.edu	37	9	77353458	77353458	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:77353458C>A	uc004ajl.1	-	36	5879	c.5641G>T	c.(5641-5643)GGG>TGG	p.G1881W	TRPM6_uc004ajk.1_Missense_Mutation_p.G1876W|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.G832W|TRPM6_uc010mpd.1_Missense_Mutation_p.G714W|TRPM6_uc010mpe.1_Missense_Mutation_p.G428W|TRPM6_uc004ajj.1_Missense_Mutation_p.G837W	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1881	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CGGAACTCCCCTGTCATATAC	0.468			NA											11	64					2.27111e-07	3.20786e-07	0.001368	1	0
PCSK5	5125	broad.mit.edu	37	9	78686767	78686767	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:78686767G>C	uc004ajz.2	+	7	1385	c.847G>C	c.(847-849)GGA>CGA	p.G283R	PCSK5_uc004ajy.2_Missense_Mutation_p.G283R|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	283	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GACTGTGGACGGACCAGCCCC	0.527			NA											47	199					0	0	0.00361	0	0
LPPR1	54886	broad.mit.edu	37	9	104071741	104071741	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:104071741A>G	uc004bbb.2	+	5	1033	c.634A>G	c.(634-636)ACG>GCG	p.T212A	LPPR1_uc011lvi.1_Missense_Mutation_p.T188A|LPPR1_uc004bbc.2_Missense_Mutation_p.T212A|LPPR1_uc010mtc.2_Missense_Mutation_p.T196A	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	212	Helical; (Potential).					integral to membrane	catalytic activity				0						CTTATATGCCACGGTGAGTGT	0.483			NA											16	52					0	0	0.007413	0	0
RAD23B	5887	broad.mit.edu	37	9	110068802	110068802	+	Missense_Mutation	SNP	C	C	A	rs111972101		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:110068802C>A	uc004bde.2	+	4	738	c.371C>A	c.(370-372)GCA>GAA	p.A124E	RAD23B_uc011lwa.1_Missense_Mutation_p.A124E|RAD23B_uc011lwb.1_Missense_Mutation_p.A103E	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	124					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						TCCACACCTGCATCCATCACT	0.567			NA						Direct_reversal_of_damage|NER					11	91					5.50884e-06	7.36575e-06	0.001368	1	0
NUP188	23511	broad.mit.edu	37	9	131743636	131743636	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:131743636C>T	uc004bws.1	+	15	1505	c.1483C>T	c.(1483-1485)CGG>TGG	p.R495W		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	495					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AACTCTTTGGCGGAGACAAAC	0.348			NA											5	166					0	0	0.000602	0	0
NUP214	8021	broad.mit.edu	37	9	134073549	134073549	+	Silent	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:134073549T>C	uc004cag.2	+	29	4779	c.4668T>C	c.(4666-4668)TCT>TCC	p.S1556S	NUP214_uc004cah.2_Silent_p.S1546S|NUP214_uc004cai.2_Silent_p.S986S|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Silent_p.S382S|NUP214_uc011mcf.1_Silent_p.S333S|NUP214_uc010mzh.1_Silent_p.S70S|NUP214_uc010mzi.1_Silent_p.S70S	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1556	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CTGCAGCATCTAGTACTAGTC	0.562	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								3	88					0	0	0.004672	0	0
CACNA1B	774	broad.mit.edu	37	9	140809117	140809117	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:140809117G>T	uc004cog.2	+	5	779	c.634G>T	c.(634-636)GTG>TTG	p.V212L		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	212	Cytoplasmic (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TTTGCAGGTGGTGCTCAAGTC	0.557			NA											11	23					1.08611e-07	1.5619e-07	0.000978	1	0
DMD	1756	broad.mit.edu	37	X	32663166	32663166	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:32663166A>C	uc004dda.1	-	10	1308	c.1064T>G	c.(1063-1065)CTT>CGT	p.L355R	DMD_uc004dcz.2_Missense_Mutation_p.L232R|DMD_uc004dcy.1_Missense_Mutation_p.L351R|DMD_uc004ddb.1_Missense_Mutation_p.L347R|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.L347R|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Missense_Mutation_p.L66R	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	355	Spectrin 1.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGCAGAAAGAAGCCACGATAA	0.408			NA											13	95					0	0	0.001368	0	0
CXorf22	170063	broad.mit.edu	37	X	35974306	35974306	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:35974306G>T	uc004ddj.2	+	8	1462	c.1403G>T	c.(1402-1404)GGT>GTT	p.G468V	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	468										large_intestine(1)|lung(1)|ovary(1)	3						ACTGGAGGGGGTATGGTGGTA	0.358			NA											15	8					6.31663e-08	9.25143e-08	0.003163	1	0
DGKK	139189	broad.mit.edu	37	X	50112015	50112015	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:50112015T>C	uc010njr.1	-	29	3800	c.3740A>G	c.(3739-3741)AAT>AGT	p.N1247S		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1247	Required for localization to the plasma membrane.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GTGCCATAAATTGCCTTCAGA	0.433			NA											3	31					0	0	0.000248	0	0
CXorf26	51260	broad.mit.edu	37	X	75396788	75396788	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:75396788G>T	uc004ecl.1	+	5	573	c.370G>T	c.(370-372)GAT>TAT	p.D124Y		NM_016500	NP_057584	Q9BVG4	CX026_HUMAN	hypothetical protein LOC51260	124											0						GCTGCGACTAGATTGTTCTCA	0.423			NA											29	23					3.90053e-15	6.65466e-15	0.002445	1	0
TNMD	64102	broad.mit.edu	37	X	99854659	99854659	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:99854659G>T	uc004efy.3	+	7	1125	c.899G>T	c.(898-900)TGT>TTT	p.C300F	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	300	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CGAGTCATCTGTCGTGTCATC	0.507			NA											13	8					5.50884e-06	7.36575e-06	0.001368	1	0
ODZ1	10178	broad.mit.edu	37	X	123554295	123554295	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:123554295C>A	uc004euj.2	-	24	4891	c.4827G>T	c.(4825-4827)TGG>TGT	p.W1609C	ODZ1_uc011muj.1_Missense_Mutation_p.W1615C|ODZ1_uc010nqy.2_Missense_Mutation_p.W1616C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1609	Extracellular (Potential).|YD 3.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTATAGTCAGCCAGTATACTT	0.527			NA											13	21					2.27111e-07	3.20786e-07	0.001368	1	0
ODZ1	10178	broad.mit.edu	37	X	123787580	123787580	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:123787580C>A	uc004euj.2	-	7	1286	c.1222G>T	c.(1222-1224)GTC>TTC	p.V408F	ODZ1_uc011muj.1_Missense_Mutation_p.V407F|ODZ1_uc010nqy.2_Missense_Mutation_p.V408F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	408	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTCTGCATGACCTGTGCACCA	0.398			NA											4	89					0.00116845	0.00145979	0.001168	1	0
PASD1	139135	broad.mit.edu	37	X	150828215	150828215	+	Missense_Mutation	SNP	T	T	G			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chrX:150828215T>G	uc004fev.3	+	10	1080	c.748T>G	c.(748-750)TAT>GAT	p.Y250D		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	250						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTGAGCAGTATGGACCACA	0.393			NA											5	64					0	0	0.000602	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576531	158576532	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:158576531_158576532insTT	uc010pio.1	+	1	303_304	c.303_304insTT	c.(301-306)ATGTTCfs	p.M101fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	101_102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTGCCCAGATGTTCTTTTCTGC	0.554			NA											8	362	---	---	---	---	NA	NA	NA	NA	NA
LAD1	3898	broad.mit.edu	37	1	201355939	201355939	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr1:201355939delA	uc001gwm.2	-	3	785	c.550delT	c.(550-552)TCCfs	p.S184fs	LAD1_uc009wzu.1_Frame_Shift_Del_p.S206fs	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	184						basement membrane	structural molecule activity				0						TTTGGCATGGAGGACTTCTCC	0.562			NA											57	135	---	---	---	---	NA	NA	NA	NA	NA
NLRP10	338322	broad.mit.edu	37	11	7981515	7981515	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:7981515delA	uc001mfv.1	-	2	1661	c.1644delT	c.(1642-1644)TTTfs	p.F548fs		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	548							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTGTTCTTTAAAATGCTTCA	0.393			NA											26	106	---	---	---	---	NA	NA	NA	NA	NA
ARAP1	116985	broad.mit.edu	37	11	72422487	72422487	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:72422487delA	uc001osu.2	-	8	1269	c.1080delT	c.(1078-1080)TTTfs	p.F360fs	ARAP1_uc001osv.2_Frame_Shift_Del_p.F360fs|ARAP1_uc001osr.2_Frame_Shift_Del_p.F120fs|ARAP1_uc001oss.2_Frame_Shift_Del_p.F115fs|ARAP1_uc009yth.2_Frame_Shift_Del_p.F115fs|ARAP1_uc010rre.1_Frame_Shift_Del_p.F115fs	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	360	PH 1.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TGTTACTGTCAAAGTATCGCA	0.567	Ovarian(102;1198 1520 13195 17913 37529)		NA											37	106	---	---	---	---	NA	NA	NA	NA	NA
MLL	4297	broad.mit.edu	37	11	118380757	118380758	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr11:118380757_118380758insA	uc001pta.2	+	30	11009_11010	c.10986_10987insA	c.(10984-10989)GAGAAAfs	p.E3662fs	MLL_uc001ptb.2_Frame_Shift_Ins_p.E3665fs	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3662_3663					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GCATTACTGAGAAAAAACCCAA	0.396			NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								40	85	---	---	---	---	NA	NA	NA	NA	NA
MYO1H	283446	broad.mit.edu	37	12	109845649	109845649	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr12:109845649delG	uc010sxn.1	+	9	1038	c.1038delG	c.(1036-1038)ATGfs	p.M346fs		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						GAGATGCAATGGCAAAGGCTG	0.443			NA											33	88	---	---	---	---	NA	NA	NA	NA	NA
POSTN	10631	broad.mit.edu	37	13	38148759	38148759	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr13:38148759delG	uc001uwo.3	-	17	2157	c.2039delC	c.(2038-2040)CCAfs	p.P680fs	POSTN_uc010tet.1_Intron|POSTN_uc001uwp.3_Intron|POSTN_uc001uwr.2_Intron|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Intron|POSTN_uc010tev.1_Intron|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	680					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTTAATTTTTGGTTCCACAAC	0.269			NA											10	28	---	---	---	---	NA	NA	NA	NA	NA
MAP2	4133	broad.mit.edu	37	2	210560407	210560408	+	Frame_Shift_Ins	INS	-	-	T			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr2:210560407_210560408insT	uc002vde.1	+	7	3761_3762	c.3513_3514insT	c.(3511-3516)GTGGAAfs	p.V1171fs	MAP2_uc002vdc.1_Frame_Shift_Ins_p.V1171fs|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Frame_Shift_Ins_p.V1167fs	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1171_1172					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATTGTCAGTGGAAATACCTTG	0.441	Pancreas(27;423 979 28787 29963)		NA											26	63	---	---	---	---	NA	NA	NA	NA	NA
LPHN3	23284	broad.mit.edu	37	4	62453151	62453152	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr4:62453151_62453152delTC	uc010ihh.2	+	2	435_436	c.262_263delTC	c.(262-264)TCTfs	p.S88fs	LPHN3_uc003hcq.3_Frame_Shift_Del_p.S88fs|LPHN3_uc010ihg.1_Frame_Shift_Del_p.S156fs	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	88	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TAAGATTATGTCTCAAAGGTAT	0.361			NA											8	25	---	---	---	---	NA	NA	NA	NA	NA
TGFBI	7045	broad.mit.edu	37	5	135379758	135379758	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:135379758delA	uc003lbf.3	+	3	406	c.245delA	c.(244-246)TACfs	p.Y82fs	TGFBI_uc003lbg.3_5'UTR|TGFBI_uc003lbh.3_5'UTR|TGFBI_uc011cyb.1_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	82	EMI.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCATCAGCTACGAGTGCTGT	0.537			NA											39	160	---	---	---	---	NA	NA	NA	NA	NA
PCDHGA2	56113	broad.mit.edu	37	5	140720800	140720801	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr5:140720800_140720801insA	uc003ljk.1	+	1	2447_2448	c.2262_2263insA	c.(2260-2265)TCCCACfs	p.S754fs	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Frame_Shift_Ins_p.S754fs|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	754_755	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCTATTCCCACGAGGTCTC	0.599			NA											48	104	---	---	---	---	NA	NA	NA	NA	NA
MYO6	4646	broad.mit.edu	37	6	76572390	76572390	+	Frame_Shift_Del	DEL	C	C	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr6:76572390delC	uc003pih.1	+	16	1903	c.1624delC	c.(1624-1626)CACfs	p.H542fs	MYO6_uc003pig.1_Frame_Shift_Del_p.H542fs|MYO6_uc003pii.1_Frame_Shift_Del_p.H542fs	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	542	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAGTGATCAACACTTTACATC	0.373			NA											9	70	---	---	---	---	NA	NA	NA	NA	NA
SND1	27044	broad.mit.edu	37	7	127732042	127732046	+	Splice_Site	DEL	CAGCT	CAGCT	-	rs113048090		TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	CAGCT	CAGCT	-	-	CAGCT	CAGCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:127732042_127732046delCAGCT	uc003vmi.2	+	24	2894	c.2668_splice	c.e24-1	p.L890_splice	SND1_uc010lle.2_Splice_Site_p.L543_splice	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1						gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						TTTTTTCTTACAGCTGAACCTGTGG	0.571			NA											18	284	---	---	---	---	NA	NA	NA	NA	NA
PTN	5764	broad.mit.edu	37	7	136936041	136936041	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr7:136936041delG	uc003vtq.2	-	4	750	c.387delC	c.(385-387)GCCfs	p.A129fs	PTN_uc010lmx.2_Frame_Shift_Del_p.A129fs|PTN_uc003vtr.1_Frame_Shift_Del_p.A129fs	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	129					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						TCTGGCATTCGGCATTGTGCA	0.507			NA											65	303	---	---	---	---	NA	NA	NA	NA	NA
PXDNL	137902	broad.mit.edu	37	8	52370103	52370103	+	Frame_Shift_Del	DEL	C	C	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr8:52370103delC	uc003xqu.3	-	9	1038	c.937delG	c.(937-939)GAAfs	p.E313fs		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	313	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GTCTTGGCTTCCCCAGCGGAA	0.428			NA											47	152	---	---	---	---	NA	NA	NA	NA	NA
ANKRD20A3	441425	broad.mit.edu	37	9	67934791	67934794	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-91-6828-01A-11D-1855-08	TCGA-91-6828-10A-01D-1855-08	AAAG	AAAG	-	-	AAAG	AAAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	99f819f2-4340-4303-8ff0-fdb03ef0151a	e202283d-04a1-4fbc-9e8e-8b5abae14385	g.chr9:67934791_67934794delAAAG	uc004aeu.2	+	4	673_676	c.561_564delAAAG	c.(559-564)AAAAGGfs	p.K187fs	ANKRD20A3_uc010mnn.2_Frame_Shift_Del_p.K187fs	NM_001012419	NP_001012419	Q5VUR7	A20A3_HUMAN	ankyrin repeat domain 20 family, member A3	187_188	ANK 4.										0						TTTTATTGAAAAAGAAAGCAAGTT	0.309			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
