Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17084510	17084510	+	Silent	SNP	G	G	A	rs61769731	by1000genomes	TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:17084510G>A	uc010ock.1	-	12	1588	c.1588C>T	c.(1588-1590)CTA>TTA	p.L530L	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.L130L	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCCGCTGTAGGCCTGGCTCT	0.577			NA											14	147					0	0	0.001855	0	0
MST1P9	11223	broad.mit.edu	37	1	17085865	17085865	+	Missense_Mutation	SNP	A	A	G	rs1057378	by1000genomes	TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:17085865A>G	uc010ock.1	-	8	956	c.956T>C	c.(955-957)CTC>CCC	p.L319P	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TGAGCCGTCGAGGTTCCAGCA	0.667			NA											4	27					0	0	0.001168	0	0
MST1P9	11223	broad.mit.edu	37	1	17085872	17085872	+	Missense_Mutation	SNP	A	A	G	rs1806514	by1000genomes	TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:17085872A>G	uc010ock.1	-	8	949	c.949T>C	c.(949-951)TGG>CGG	p.W317R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TCGAGGTTCCAGCAGAAGTTC	0.662			NA											4	28					0	0	0.001168	0	0
NR0B2	8431	broad.mit.edu	37	1	27238432	27238432	+	Silent	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:27238432G>A	uc001bnf.2	-	2	814	c.678C>T	c.(676-678)TCC>TCT	p.S226S		NM_021969	NP_068804	Q15466	NR0B2_HUMAN	short heterodimer partner	226	Ligand-binding (By similarity).				cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TGGTCGGAATGGACTTGAGGG	0.602			NA											73	181					0	0	0.00361	0	0
SFRS4	6429	broad.mit.edu	37	1	29481238	29481238	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:29481238C>A	uc001bro.2	-	4	921	c.548G>T	c.(547-549)CGG>CTG	p.R183L	SFRS4_uc010ofy.1_Intron|SFRS4_uc009vtp.2_RNA	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	183	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		GGAGTAGGACCGGCGTCGTCT	0.398			NA											29	73					6.00712e-18	1.51523e-17	0.002445	1	0
CYP4B1	1580	broad.mit.edu	37	1	47276491	47276491	+	Silent	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:47276491G>A	uc001cqm.3	+	2	276	c.192G>A	c.(190-192)ACG>ACA	p.T64T	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Silent_p.T64T|CYP4B1_uc009vym.2_Silent_p.T64T|CYP4B1_uc010omk.1_Intron|CYP4B1_uc010oml.1_5'Flank	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	64					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TCCAGGAGACGGGGAGCCTGG	0.577			NA											38	78					0	0	0.007835	0	0
RAB3B	5865	broad.mit.edu	37	1	52403001	52403001	+	Silent	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:52403001G>T	uc001cth.2	-	3	437	c.312C>A	c.(310-312)ATC>ATA	p.I104I		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	104					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						CTTCATTGGTGATGTCATACA	0.388			NA											82	160					1.26458e-31	3.59184e-31	0.00361	1	0
GDAP2	54834	broad.mit.edu	37	1	118454705	118454705	+	Splice_Site	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:118454705C>T	uc001ehf.2	-	5	770	c.471_splice	c.e5-1	p.K157_splice	GDAP2_uc001ehg.2_Splice_Site_p.K157_splice	NM_017686	NP_060156	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated											ovary(2)	2		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		TGACTGCTCTCTGCAACAAAG	0.353			NA											12	39					0	0	0.001855	0	0
OR6N2	81442	broad.mit.edu	37	1	158746799	158746799	+	Silent	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:158746799G>T	uc010pir.1	-	1	627	c.627C>A	c.(625-627)ATC>ATA	p.I209I		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					AGAAGAAAGTGATAAGAATTA	0.408			NA											16	74					4.75885e-15	1.13274e-14	0.00499	1	0
TNR	7143	broad.mit.edu	37	1	175334271	175334271	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:175334271G>A	uc001gkp.1	-	10	2543	c.2462C>T	c.(2461-2463)TCC>TTC	p.S821F	TNR_uc009wwu.1_Missense_Mutation_p.S821F	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	821	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGCATCCAGGGAGACCTCCAT	0.537			NA											19	175					0	0	0.008871	0	0
XPR1	9213	broad.mit.edu	37	1	180775265	180775265	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:180775265G>A	uc001goi.2	+	5	707	c.515G>A	c.(514-516)GGA>GAA	p.G172E	XPR1_uc009wxm.2_Missense_Mutation_p.G172E|XPR1_uc009wxn.2_Missense_Mutation_p.G172E	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	172	SPX.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						ACATCTCGTGGAGCAGATTGG	0.388			NA											32	112					0	0	0.001786	0	0
GLT25D2	23127	broad.mit.edu	37	1	183947644	183947644	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:183947644C>A	uc001gqr.2	-	2	646	c.274G>T	c.(274-276)GAT>TAT	p.D92Y	GLT25D2_uc010poj.1_Missense_Mutation_p.D92Y|GLT25D2_uc001gqs.2_5'UTR	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	92					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						ACATTGTGATCAGTGGCTGCC	0.408	Esophageal Squamous(10;42 606 18489 38825)		NA											38	129					3.76114e-14	8.82822e-14	0.004289	1	0
IVNS1ABP	10625	broad.mit.edu	37	1	185270131	185270131	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:185270131C>G	uc001grl.2	-	10	1716	c.1093G>C	c.(1093-1095)GAG>CAG	p.E365Q	IVNS1ABP_uc001gri.2_Missense_Mutation_p.E25Q|IVNS1ABP_uc001grj.2_Missense_Mutation_p.E25Q|IVNS1ABP_uc009wyj.2_Missense_Mutation_p.E147Q|IVNS1ABP_uc009wyk.2_RNA|IVNS1ABP_uc001grm.2_Missense_Mutation_p.E25Q	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	365	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						CCATTCATCTCTGCTGTTCCC	0.423			NA											39	157					0	0	0.002522	0	0
OR2L1P	26247	broad.mit.edu	37	1	248153914	248153914	+	Silent	SNP	A	A	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:248153914A>G	uc001idv.1	+	1	346	c.102A>G	c.(100-102)ACA>ACG	p.T34T	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						TGCTCCTGACATCAATGGCCT	0.443			NA											58	168					0	0	0.00361	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702244	27702244	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:27702244C>A	uc001itu.2	-	1	1054	c.936G>T	c.(934-936)ATG>ATT	p.M312I		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	312	Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTAACTGGCCCATTCCTAGGC	0.602			NA											51	141					2.74695e-27	7.54854e-27	0.00361	1	0
ASAH2	56624	broad.mit.edu	37	10	51978297	51978297	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:51978297C>T	uc001jjd.2	-	7	987	c.987G>A	c.(985-987)GAG>GAA	p.E329E	ASAH2_uc009xos.2_Silent_p.E329E	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	329	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						CTTTGTTCTTCTCTTGCTCAA	0.423			NA											35	106					0	0	0.00361	0	0
MBL2	4153	broad.mit.edu	37	10	54531287	54531287	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:54531287C>A	uc001jjt.2	-	1	174	c.109G>T	c.(109-111)GCC>TCC	p.A37S		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	37	Cys-rich.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						GAGCTACAGGCAATCACTGCA	0.552			NA											45	74					1.51926e-22	4.04337e-22	0.00361	1	0
SORCS1	114815	broad.mit.edu	37	10	108536324	108536324	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:108536324C>T	uc001kym.2	-	4	861	c.853G>A	c.(853-855)GAC>AAC	p.D285N	SORCS1_uc001kyl.2_Missense_Mutation_p.D285N|SORCS1_uc009xxs.2_Missense_Mutation_p.D285N|SORCS1_uc001kyn.1_Missense_Mutation_p.D285N|SORCS1_uc001kyo.2_Missense_Mutation_p.D285N	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	285	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGAATCCAGTCTTCTTGTTTG	0.413			NA											61	145					0	0	0.00361	0	0
SORCS1	114815	broad.mit.edu	37	10	108923969	108923969	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:108923969C>A	uc001kym.2	-	1	324	c.316G>T	c.(316-318)GGC>TGC	p.G106C	SORCS1_uc001kyl.2_Missense_Mutation_p.G106C|SORCS1_uc009xxs.2_Missense_Mutation_p.G106C|SORCS1_uc001kyn.1_Missense_Mutation_p.G106C|SORCS1_uc001kyo.2_Missense_Mutation_p.G106C	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	106	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTCCTCCGGCCGGAGCGTGCA	0.701			NA											21	29					1.96292e-10	4.48289e-10	0.001523	1	0
ADAM12	8038	broad.mit.edu	37	10	127705850	127705850	+	Nonstop_Mutation	SNP	A	A	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr10:127705850A>T	uc001ljk.2	-	23	3141	c.2728T>A	c.(2728-2730)TGA>AGA	p.*910R	ADAM12_uc010qul.1_Nonstop_Mutation_p.*861R|ADAM12_uc001ljj.1_5'Flank	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	910					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TCGGCTTCTCACTTAATATAG	0.403			NA											10	15					0	0	0.000978	0	0
OR51S1	119692	broad.mit.edu	37	11	4870118	4870118	+	Silent	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr11:4870118T>A	uc010qyo.1	-	1	321	c.321A>T	c.(319-321)CTA>CTT	p.L107L		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	107	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAACCATCTGTAGAAGGCAGG	0.542			NA											62	112					0	0	0.00361	0	0
OR52N2	390077	broad.mit.edu	37	11	5842289	5842289	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr11:5842289A>G	uc010qzp.1	+	1	724	c.724A>G	c.(724-726)ACC>GCC	p.T242A	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCCTTCAGCACCTGCACATC	0.418			NA											41	116					0	0	0.00361	0	0
APIP	51074	broad.mit.edu	37	11	34904943	34904943	+	Silent	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr11:34904943T>A	uc001mvs.2	-	6	678	c.570A>T	c.(568-570)GTA>GTT	p.V190V	APIP_uc010reo.1_Silent_p.V207V	NM_015957	NP_057041	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	190					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity				0	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			GTCTGACCAGTACTGCACAGG	0.448			NA											99	212					0	0	0.00361	0	0
SPTBN2	6712	broad.mit.edu	37	11	66455642	66455642	+	Silent	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr11:66455642G>A	uc001ojd.2	-	31	6444	c.6372C>T	c.(6370-6372)GAC>GAT	p.D2124D	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2124					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCTCTCACCCGTCCCAGGTGG	0.637			NA											15	47					0	0	0.00245	0	0
ING4	51147	broad.mit.edu	37	12	6761453	6761453	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr12:6761453C>A	uc001qpw.3	-	6	673	c.632G>T	c.(631-633)GGC>GTC	p.G211V	ING4_uc001qpv.3_Missense_Mutation_p.G210V|ING4_uc001qpy.3_Missense_Mutation_p.G207V|ING4_uc001qpx.3_Missense_Mutation_p.G208V|ING4_uc009zes.2_Intron|ING4_uc009zet.2_Missense_Mutation_p.G187V|ING4_uc009zeu.2_RNA|ING4_uc009zev.2_RNA	NM_001127582	NP_001121054	Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4 isoform 9	211	PHD-type.				apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|ovary(1)	4						GTTGTCACAGCCAATCATCTC	0.507			NA											51	110					3.39706e-21	8.90081e-21	0.00361	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	20					0.00448238	0.00958889	0.004482	1	0
ARID2	196528	broad.mit.edu	37	12	46230571	46230571	+	Nonsense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr12:46230571C>T	uc001ros.1	+	8	820	c.820C>T	c.(820-822)CGA>TGA	p.R274*	ARID2_uc001ror.2_Nonsense_Mutation_p.R274*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	274					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCATCCACCTCGAAAGCTGGG	0.363			NA											30	43					0	0	0.002445	0	0
SENP1	29843	broad.mit.edu	37	12	48457499	48457499	+	Silent	SNP	A	A	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr12:48457499A>G	uc001rqx.2	-	13	1847	c.1401T>C	c.(1399-1401)AAT>AAC	p.N467N	SENP1_uc001rqw.2_Silent_p.N467N|SENP1_uc001rqy.2_Silent_p.N268N|SENP1_uc001rqz.2_Silent_p.N268N|SENP1_uc009zkx.2_Silent_p.N467N	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	467	Protease.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TTACCTCATCATTGAGCCAAT	0.308			NA											28	76					0	0	0.00632	0	0
ACTN1	87	broad.mit.edu	37	14	69378902	69378902	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr14:69378902C>A	uc001xkl.2	-	4	708	c.398G>T	c.(397-399)CGC>CTC	p.R133L	ACTN1_uc010ttb.1_Missense_Mutation_p.R68L|ACTN1_uc001xkm.2_Missense_Mutation_p.R133L|ACTN1_uc001xkn.2_Missense_Mutation_p.R133L|ACTN1_uc001xko.1_Missense_Mutation_p.R68L|ACTN1_uc010ttd.1_Missense_Mutation_p.R112L	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	133	CH 1.|Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GATGGCAAAGCGCAGGATGAT	0.552			NA									OREG0022758	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	151					1.95512e-22	5.16274e-22	0.00361	1	0
CPSF2	53981	broad.mit.edu	37	14	92625582	92625582	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr14:92625582G>T	uc001yah.1	+	14	2314	c.2077G>T	c.(2077-2079)GAA>TAA	p.E693*		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	693					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		AACAGGTGAAGAAAGTGAGAT	0.403	Ovarian(78;28 1788 18702 44111)		NA											18	77					2.39187e-15	5.73371e-15	0.008871	1	0
KIAA1409	57578	broad.mit.edu	37	14	94107507	94107507	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr14:94107507C>T	uc001ybv.1	+	32	5552	c.5469C>T	c.(5467-5469)AGC>AGT	p.S1823S	KIAA1409_uc001ybs.1_Silent_p.S1801S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1978						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CCAAATCCAGCCTGCTATCAG	0.522			NA											10	30					0	0	0.008291	0	0
NIPA1	123606	broad.mit.edu	37	15	23048975	23048975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:23048975C>A	uc001yvc.2	-	5	869	c.844G>T	c.(844-846)GAG>TAG	p.E282*	NIPA1_uc001yvd.2_Nonsense_Mutation_p.E112*|NIPA1_uc001yve.2_Nonsense_Mutation_p.E207*	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	282	Extracellular (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		TTGCTCCACTCCCGGAAGAGG	0.577			NA											15	21					4.14922e-12	9.60572e-12	0.004007	1	0
C15orf2	23742	broad.mit.edu	37	15	24923547	24923547	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:24923547G>T	uc001ywo.2	+	1	3007	c.2533G>T	c.(2533-2535)GAG>TAG	p.E845*		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	845					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTCCAGGAAGGAGGAGTACAT	0.498			NA											59	124					1.73933e-33	5.06804e-33	0.00361	1	0
CTDSPL2	51496	broad.mit.edu	37	15	44789292	44789292	+	Silent	SNP	T	T	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:44789292T>C	uc001ztr.2	+	7	1254	c.838T>C	c.(838-840)TTG>CTG	p.L280L	CTDSPL2_uc001zts.2_Silent_p.L280L|CTDSPL2_uc001ztt.2_Silent_p.L280L|CTDSPL2_uc010bdv.2_Silent_p.L208L	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	280							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		TGCTCTTCCGTTGAAAACAAG	0.343			NA											24	73					0	0	0.00632	0	0
UNC13C	440279	broad.mit.edu	37	15	54307911	54307911	+	Silent	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:54307911C>G	uc002ack.2	+	1	2811	c.2811C>G	c.(2809-2811)CCC>CCG	p.P937P		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	937					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGTTAGAACCCTTAAATGAAA	0.403			NA											30	53					0	0	0.00632	0	0
EFTUD1	79631	broad.mit.edu	37	15	82533632	82533632	+	Silent	SNP	A	A	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:82533632A>T	uc002bgt.1	-	5	526	c.357T>A	c.(355-357)GCT>GCA	p.A119A	EFTUD1_uc002bgu.1_Silent_p.A68A	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	119					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						CTCCTTCCACAGCATCTACCA	0.443			NA											31	74					0	0	0.002836	0	0
AGBL1	123624	broad.mit.edu	37	15	86800211	86800211	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:86800211G>C	uc002blz.1	+	7	805	c.725G>C	c.(724-726)GGG>GCG	p.G242A		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	242					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CCGGTCCCCGGGTGCATCACC	0.502			NA											21	40					0	0	0.00278	0	0
LRRK1	79705	broad.mit.edu	37	15	101608898	101608898	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:101608898G>T	uc002bwr.2	+	34	6212	c.5893G>T	c.(5893-5895)GTG>TTG	p.V1965L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1965					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGCTGCCGTGGTGGCAAAGGA	0.597			NA											57	116					6.26901e-30	1.76577e-29	0.00361	1	0
GNG13	51764	broad.mit.edu	37	16	849011	849012	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr16:849011_849012GG>TT	uc002ckh.3	-	2	168_169	c.66_67CC>AA	c.(64-69)TTCCAG>TTAAAG	p.22_23FQ>LK		NM_016541	NP_057625	Q9P2W3	GBG13_HUMAN	guanine nucleotide binding protein (G protein),	22_23					cellular response to glucagon stimulus|energy reserve metabolic process		signal transducer activity				0		Hepatocellular(780;0.00335)				ATCTCCCGCTGGAAGGCCAGCT	0.609			NA											9	34					0	0	0.004672	0	0
SRRM2	23524	broad.mit.edu	37	16	2814911	2814911	+	Missense_Mutation	SNP	G	G	T	rs149555495	byFrequency	TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr16:2814911G>T	uc002crk.2	+	11	4931	c.4382G>T	c.(4381-4383)GGG>GTG	p.G1461V	SRRM2_uc002crj.1_Missense_Mutation_p.G1365V|SRRM2_uc002crl.1_Missense_Mutation_p.G1461V|SRRM2_uc010bsu.1_Missense_Mutation_p.G1365V	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1461	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGCCTGTCTGGGTCCTCTCCT	0.517			NA											68	149					7.93275e-45	2.41556e-44	0.00361	1	0
CORO7	79585	broad.mit.edu	37	16	4408035	4408035	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr16:4408035C>A	uc002cwh.3	-	25	2647	c.2527G>T	c.(2527-2529)GCC>TCC	p.A843S	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.A843S|CORO7_uc002cwg.3_Missense_Mutation_p.A623S|CORO7_uc010uxh.1_Missense_Mutation_p.A825S|CORO7_uc010uxi.1_Missense_Mutation_p.A758S|CORO7_uc002cwi.1_3'UTR	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	843						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TGCAGCCAGGCCTCGGCACTG	0.627			NA											32	84					5.90632e-09	1.31338e-08	0.002445	1	0
MLKL	197259	broad.mit.edu	37	16	74709626	74709626	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr16:74709626T>A	uc002fdb.2	-	8	1516	c.1075A>T	c.(1075-1077)ATG>TTG	p.M359L	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	359	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						CCCAAACTCATGGAAGTCTGT	0.408			NA											38	94					0	0	0.005524	0	0
KIAA1609	57707	broad.mit.edu	37	16	84520279	84520279	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr16:84520279C>A	uc002fib.2	-	5	1023	c.916G>T	c.(916-918)GGG>TGG	p.G306W	KIAA1609_uc010vod.1_Missense_Mutation_p.G279W|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	306	TLD.						protein binding			ovary(2)	2						GAGGCAAACCCACCGAACACA	0.567			NA											23	93					1.85244e-09	4.17417e-09	0.00333	1	0
SHPK	23729	broad.mit.edu	37	17	3539511	3539511	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr17:3539511C>T	uc002fvz.1	-	1	106	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CTNS_uc002fwa.2_5'Flank|CTNS_uc002fwb.2_5'Flank|CTNS_uc010ckj.2_5'Flank|CTNS_uc010vrv.1_5'Flank|CTNS_uc010vrw.1_5'Flank	NM_013276	NP_037408	Q9UHJ6	SHPK_HUMAN	carbohydrate kinase-like	1					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)		GCCGCGCAGCCATTATCTCCC	0.711			NA											17	51					0	0	0.006122	0	0
PIK3R6	146850	broad.mit.edu	37	17	8736345	8736345	+	Silent	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr17:8736345G>T	uc002glq.1	-	9	903	c.663C>A	c.(661-663)ACC>ACA	p.T221T	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_Intron	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	221					platelet activation	cytosol					0						AGTGCTCCAGGGTGCGGCGAG	0.692			NA											11	25					4.68919e-08	1.02919e-07	0.008291	1	0
SOX9	6662	broad.mit.edu	37	17	70117604	70117604	+	Silent	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr17:70117604C>G	uc002jiw.2	+	1	444	c.72C>G	c.(70-72)CCC>CCG	p.P24P	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	24					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CCCCCAGCCCCACCATGTCCG	0.711	Pancreas(42;83 1041 2320 35205 39456)		NA											10	44					0	0	0.000978	0	0
KLHL14	57565	broad.mit.edu	37	18	30257294	30257294	+	Splice_Site	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr18:30257294C>G	uc002kxm.1	-	8	1977	c.1589_splice	c.e8-1	p.G530_splice	KLHL14_uc010dmd.1_Splice_Site_p.G79_splice	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14							cytosol|endoplasmic reticulum membrane				ovary(1)	1						TGGGAGAAACCTAAGTGACAG	0.423			NA											17	47					0	0	0.004007	0	0
SETBP1	26040	broad.mit.edu	37	18	42531491	42531492	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr18:42531491_42531492GG>TT	uc010dni.2	+	4	2482_2483	c.2186_2187GG>TT	c.(2185-2187)AGG>ATT	p.R729I		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	729						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGCGGGGCAGGAAGCCAAGAG	0.574			NA							Schinzel-Giedion_syndrome				21	53					0	0	0.004672	0	0
MYO5B	4645	broad.mit.edu	37	18	47364056	47364056	+	Missense_Mutation	SNP	T	T	C	rs75537257		TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr18:47364056T>C	uc002leb.2	-	37	5257	c.4969A>G	c.(4969-4971)ATC>GTC	p.I1657V	MYO5B_uc002ldz.2_Missense_Mutation_p.I227V|MYO5B_uc002lea.2_Missense_Mutation_p.I772V	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1657	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGGCGGATGATAGCTTCCAGG	0.507			NA											47	84					0	0	0.003214	0	0
STK11	6794	broad.mit.edu	37	19	1221946	1221946	+	Splice_Site	SNP	A	A	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:1221946A>T	uc002lrl.1	+	7	1978	c.863_splice	c.e7-2	p.G288_splice		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11						anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCTCCTCAGGGATGCTTG	0.677			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			4	0					0	0	0.000602	0	0
SLC25A23	79085	broad.mit.edu	37	19	6457519	6457519	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:6457519C>A	uc002mex.1	-	3	508	c.366G>T	c.(364-366)TTG>TTT	p.L122F	SLC25A23_uc002mev.2_RNA|SLC25A23_uc010xjd.1_5'Flank	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	122	EF-hand 3.|Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						CTCACCTGTGCAAAATTTTCT	0.562			NA											25	36					2.70662e-09	6.05853e-09	0.001786	1	0
KEAP1	9817	broad.mit.edu	37	19	10610235	10610235	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:10610235C>G	uc002moq.1	-	2	631	c.475G>C	c.(475-477)GCT>CCT	p.A159P	KEAP1_uc002mor.1_Missense_Mutation_p.A159P	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TACATGACAGCACCGTTCATG	0.582			NA											37	51					0	0	0.006999	0	0
CILP2	148113	broad.mit.edu	37	19	19655215	19655215	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:19655215G>T	uc002nmv.3	+	8	1946	c.1861G>T	c.(1861-1863)GCC>TCC	p.A621S	CILP2_uc002nmw.3_Missense_Mutation_p.A627S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	621						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GGCGGCGTCTGCCCCCAGTGA	0.701			NA											53	74					1.46156e-29	4.0827e-29	0.00361	1	0
PSG4	5672	broad.mit.edu	37	19	43708259	43708259	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:43708259C>G	uc002ovy.2	-	2	311	c.209G>C	c.(208-210)GGG>GCG	p.G70A	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.G70A|PSG4_uc002ovz.2_Missense_Mutation_p.G70A	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	70	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				TGTCATTTGCCCTTTGTACCA	0.423			NA											135	106					0	0	0.00361	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461674	50461674	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:50461674G>T	uc010ybh.1	-	8	1608	c.1517C>A	c.(1516-1518)ACC>AAC	p.T506N	SIGLEC11_uc010ybi.1_Intron	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	506	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TGAGCTGGGGGTGACCTCGAA	0.701			NA											16	35					3.41278e-10	7.74175e-10	0.00499	1	0
ZNF677	342926	broad.mit.edu	37	19	53747009	53747009	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:53747009G>T	uc002qbf.1	-	4	342	c.157C>A	c.(157-159)CCT>ACT	p.P53T	ZNF677_uc002qbg.1_Missense_Mutation_p.P53T|ZNF677_uc002qbh.2_RNA	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TCTTCTGGAGGGATGTTATCC	0.507			NA											55	131					1.82294e-38	5.45269e-38	0.00361	1	0
MYADM	91663	broad.mit.edu	37	19	54377408	54377408	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:54377408G>T	uc002qcl.2	+	3	773	c.625G>T	c.(625-627)GTG>TTG	p.V209L	MYADM_uc002qcm.2_Missense_Mutation_p.V209L|MYADM_uc002qcn.2_Missense_Mutation_p.V209L|MYADM_uc002qco.2_Missense_Mutation_p.V209L|MYADM_uc002qcp.2_Missense_Mutation_p.V209L	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	209	MARVEL 2.|Helical; (Potential).					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		GTGCGTGGCGGTGTACGCCAT	0.627			NA											84	205					1.16668e-32	3.3704e-32	0.00361	1	0
LILRA6	79168	broad.mit.edu	37	19	54745554	54745554	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:54745554C>T	uc002qeu.1	-	4	680	c.556G>A	c.(556-558)GTG>ATG	p.V186M	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Missense_Mutation_p.V186M|LILRA6_uc002qek.1_Missense_Mutation_p.V186M|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.V186M|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.V186M|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.V186M|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.V186M|LILRA6_uc010yep.1_Missense_Mutation_p.V186M|LILRA6_uc010yeq.1_Missense_Mutation_p.V186M|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.V47M	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	186	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGGGGGTCACGGGGCCCACA	0.602			NA											32	91					0	0	0.002852	0	0
LILRA5	353514	broad.mit.edu	37	19	54823398	54823398	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:54823398G>T	uc002qfe.2	-	4	265	c.145C>A	c.(145-147)CTC>ATC	p.L49I	LILRA5_uc002qff.2_Missense_Mutation_p.L37I|LILRA5_uc010yev.1_Missense_Mutation_p.L49I|LILRA5_uc010yew.1_Missense_Mutation_p.L37I|LILRA5_uc002qfh.1_Missense_Mutation_p.L37I|LILRA5_uc002qfg.1_Missense_Mutation_p.L49I	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	49	Extracellular (Potential).				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCAGCCCAGAGGGTGGCTTTG	0.622			NA											36	96					1.36161e-19	3.48656e-19	0.004289	1	0
SAPS1	22870	broad.mit.edu	37	19	55753857	55753857	+	Splice_Site	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:55753857C>G	uc002qjw.3	-	6	861	c.619_splice	c.e6-1	p.Q207_splice	SAPS1_uc002qjv.2_Splice_Site_p.Q269_splice	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1						regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TGGAATGTTGCTGGAACGGGG	0.622			NA											32	72					0	0	0.001786	0	0
ZNF543	125919	broad.mit.edu	37	19	57835140	57835140	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:57835140G>T	uc002qoi.1	+	2	454	c.109G>T	c.(109-111)GTG>TTG	p.V37L		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTATCAGGAGGTGATGCTGGA	0.532			NA											55	151					1.10885e-35	3.28764e-35	0.00361	1	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358			NA											3	7					0	0	0.004672	0	0
NRXN1	9378	broad.mit.edu	37	2	50779780	50779780	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:50779780C>A	uc010fbq.2	-	9	3301	c.1824G>T	c.(1822-1824)AAG>AAT	p.K608N	NRXN1_uc002rxb.3_Missense_Mutation_p.K240N|NRXN1_uc002rxe.3_Missense_Mutation_p.K568N|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATTCACTTTCTTCAACAGGG	0.443			NA											58	169					1.08141e-31	3.09759e-31	0.00361	1	0
XPO1	7514	broad.mit.edu	37	2	61706009	61706009	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:61706009C>A	uc002sbj.2	-	25	3890	c.3162G>T	c.(3160-3162)ATG>ATT	p.M1054I	XPO1_uc010fcl.2_Missense_Mutation_p.M1050I|XPO1_uc010ypn.1_Missense_Mutation_p.M1050I|XPO1_uc002sbk.2_Missense_Mutation_p.M615I|XPO1_uc002sbg.2_Missense_Mutation_p.M251I|XPO1_uc002sbh.2_Missense_Mutation_p.M701I	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	1054					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			CAGGGACAGACATTTGACGTT	0.393			NA											25	89					7.92952e-12	1.82325e-11	0.003954	1	0
XPO1	7514	broad.mit.edu	37	2	61729132	61729132	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:61729132T>A	uc002sbj.2	-	6	1135	c.407A>T	c.(406-408)CAG>CTG	p.Q136L	XPO1_uc010fcl.2_Missense_Mutation_p.Q132L|XPO1_uc010ypn.1_Missense_Mutation_p.Q132L|XPO1_uc002sbk.2_5'UTR	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	136	Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AAAGCTTACCTGAACAAGGAT	0.269			NA											12	43					0	0	0.000978	0	0
NEB	4703	broad.mit.edu	37	2	152383524	152383524	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:152383524G>T	uc010fnx.2	-	120	16941	c.16750C>A	c.(16750-16752)CTG>ATG	p.L5584M	NEB_uc002txr.2_Missense_Mutation_p.L2007M|NEB_uc002txt.3_Missense_Mutation_p.L89M	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5584	Nebulin 152.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCCGGTCCAGCTTATATTCA	0.453			NA											6	24					2.7689e-08	6.11691e-08	0.001984	1	0
NEB	4703	broad.mit.edu	37	2	152432670	152432670	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:152432670T>C	uc010fnx.2	-	78	11991	c.11800A>G	c.(11800-11802)AGT>GGT	p.S3934G	NEB_uc002txr.2_Missense_Mutation_p.S357G	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3934	Nebulin 107.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCACAATACTAATATTTTCA	0.308			NA											12	33					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179594055	179594055	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:179594055T>A	uc010zfg.1	-	61	15320	c.15096A>T	c.(15094-15096)GAA>GAT	p.E5032D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1693D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5959							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTGCCGCCTTCATTGGATA	0.413			NA											73	156					0	0	0.00361	0	0
FAM117B	150864	broad.mit.edu	37	2	203591005	203591005	+	Missense_Mutation	SNP	T	T	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:203591005T>A	uc010zhx.1	+	4	889	c.879T>A	c.(877-879)AGT>AGA	p.S293R		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	293										ovary(1)	1						TGCAGAGAAGTAAACACAGCA	0.408			NA											64	153					0	0	0.00361	0	0
ERBB4	2066	broad.mit.edu	37	2	212589824	212589824	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:212589824C>A	uc002veg.1	-	6	816	c.718G>T	c.(718-720)GGA>TGA	p.G240*	ERBB4_uc002veh.1_Nonsense_Mutation_p.G240*|ERBB4_uc010zji.1_Nonsense_Mutation_p.G240*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.G240*|ERBB4_uc010fut.1_Nonsense_Mutation_p.G240*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	240	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCTTAGGTCCTGAGCAGCCT	0.478			NA								TSP Lung(8;0.080)			55	95					3.07002e-29	8.50546e-29	0.00361	1	0
SLC11A1	6556	broad.mit.edu	37	2	219249006	219249006	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr2:219249006C>T	uc002vhv.2	+	3	531	c.191C>T	c.(190-192)CCT>CTT	p.P64L	SLC11A1_uc010zkb.1_Missense_Mutation_p.P64L|SLC11A1_uc010fvp.1_Missense_Mutation_p.P64L|SLC11A1_uc010fvq.1_5'UTR|SLC11A1_uc010zkc.1_5'UTR|SLC11A1_uc002vhu.1_Intron|SLC11A1_uc002vhw.2_5'UTR|SLC11A1_uc010fvr.2_5'Flank	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	64	Helical; (Potential).|Pro/Ser-rich.				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCACGGGGCCTGGCTTCCTC	0.597			NA											74	217					0	0	0.00361	0	0
CST4	1472	broad.mit.edu	37	20	23666557	23666557	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr20:23666557C>G	uc002wto.1	-	3	456	c.400G>C	c.(400-402)GTG>CTG	p.V134L		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	134						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CTGGAATTCACCAGGGACATT	0.557			NA											23	66					0	0	0.00632	0	0
ETS2	2114	broad.mit.edu	37	21	40194699	40194699	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr21:40194699G>T	uc002yxg.2	+	10	1492	c.1296G>T	c.(1294-1296)AAG>AAT	p.K432N	ETS2_uc002yxf.2_Missense_Mutation_p.K572N	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	432	ETS.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCATCCACAAGACGTCGGGGA	0.587			NA											28	64					4.92203e-23	1.32035e-22	0.00623	1	0
COL18A1	80781	broad.mit.edu	37	21	46917542	46917542	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr21:46917542G>A	uc011afs.1	+	31	3916	c.3895G>A	c.(3895-3897)GCC>ACC	p.A1299T	COL18A1_uc002zhg.2_Missense_Mutation_p.A884T|COL18A1_uc002zhi.2_Missense_Mutation_p.A1064T	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1299	Triple-helical region 7 (COL7).			A -> P (in Ref. 5; AAA51864).	cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		ACCCAAGGGCGCCAAAGGAGA	0.652			NA											3	6					0	0	0.000248	0	0
LZTR1	8216	broad.mit.edu	37	22	21336817	21336817	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr22:21336817C>T	uc002zto.2	+	1	260	c.157C>T	c.(157-159)CGC>TGC	p.R53C	LZTR1_uc002ztn.2_Intron|LZTR1_uc011ahy.1_Missense_Mutation_p.R53C	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	53					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AACAGTGCATCGCTGGCGGCG	0.662			NA											14	32					0	0	0.003163	0	0
C3orf20	84077	broad.mit.edu	37	3	14755649	14755649	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr3:14755649C>A	uc003byy.2	+	8	1700	c.1296C>A	c.(1294-1296)CAC>CAA	p.H432Q	C3orf20_uc003byz.2_Missense_Mutation_p.H310Q|C3orf20_uc003bza.2_Missense_Mutation_p.H310Q|C3orf20_uc003bzb.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	432						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GCTGTGTTCACTACAACCTAA	0.517			NA											27	53					3.6726e-16	8.86671e-16	0.003954	1	0
SLC9A10	285335	broad.mit.edu	37	3	111958724	111958724	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr3:111958724A>T	uc003dyu.2	-	12	1631	c.1409T>A	c.(1408-1410)ATG>AAG	p.M470K	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.M422K	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	470					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TTTCTCAATCATGTTCCAATC	0.338			NA											13	61					0	0	0.001855	0	0
ESYT3	83850	broad.mit.edu	37	3	138191512	138191514	+	Missense_Mutation	TNP	AGA	AGA	GTC			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	AGA	AGA	-	-	AGA	AGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr3:138191512_138191514AGA>GTC	uc003esk.2	+	18	2274_2276	c.2048_2050AGA>GTC	c.(2047-2052)AAGAGT>AGTCGT	p.683_684KS>SR	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	683_684						integral to membrane|plasma membrane					0						GGGGAGAAGAAGAGTCCAGCCAC	0.596			NA											29	114					0	0	0.004672	0	0
SI	6476	broad.mit.edu	37	3	164792419	164792419	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr3:164792419C>T	uc003fei.2	-	3	217	c.155G>A	c.(154-156)CGT>CAT	p.R52H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	52	Ser/Thr-rich.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTAGTCACACGAGTAGTAGC	0.338			NA								HNSCC(35;0.089)			25	109					0	0	0.007291	0	0
TP63	8626	broad.mit.edu	37	3	189526252	189526252	+	Silent	SNP	A	A	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr3:189526252A>G	uc003fry.2	+	4	605	c.516A>G	c.(514-516)CCA>CCG	p.P172P	TP63_uc003frx.2_Silent_p.P172P|TP63_uc003frz.2_Silent_p.P172P|TP63_uc010hzc.1_Silent_p.P172P|TP63_uc003fsa.2_Silent_p.P78P|TP63_uc003fsb.2_Silent_p.P78P|TP63_uc003fsc.2_Silent_p.P78P|TP63_uc003fsd.2_Silent_p.P78P|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Silent_p.P53P	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	172					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCGACTACCCAGGCCCGCACA	0.652			NA							Hay-Wells_syndrome	HNSCC(45;0.13)			31	83					0	0	0.008361	0	0
KIAA1109	84162	broad.mit.edu	37	4	123171706	123171706	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr4:123171706G>A	uc003ieh.2	+	35	5945	c.5900G>A	c.(5899-5901)GGA>GAA	p.G1967E	KIAA1109_uc003iek.2_Missense_Mutation_p.G586E	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1967					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GACTTAAATGGAAATTCTGTT	0.338			NA											39	75					0	0	0.00874	0	0
RASGRF2	5924	broad.mit.edu	37	5	80419539	80419539	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:80419539G>T	uc003kha.1	+	16	2549	c.2549G>T	c.(2548-2550)TGC>TTC	p.C850F	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	850					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CTTTCACCTTGCAGATCCCCC	0.517			NA											29	81					1.88708e-17	4.65573e-17	0.008361	1	0
GIN1	54826	broad.mit.edu	37	5	102432325	102432325	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:102432325C>T	uc003koa.1	-	7	1296	c.1214G>A	c.(1213-1215)AGA>AAA	p.R405K	GIN1_uc003kob.1_Missense_Mutation_p.R258K|GIN1_uc003koc.1_Intron	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	405					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		AGTGTTGTCTCTCAGGACAGC	0.418			NA											99	240					0	0	0.00361	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362939	128362939	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:128362939G>T	uc003kuy.2	+	8	1765	c.1369G>T	c.(1369-1371)GAT>TAT	p.D457Y	SLC27A6_uc003kuz.2_Missense_Mutation_p.D457Y	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	457					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TAAGAAGGGAGATGTTTACCT	0.378			NA											58	117					9.72345e-25	2.65042e-24	0.00361	1	0
CTNNA1	1495	broad.mit.edu	37	5	138266210	138266210	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:138266210C>G	uc003ldh.2	+	15	2154	c.2059C>G	c.(2059-2061)CAG>GAG	p.Q687E	CTNNA1_uc011cyx.1_Missense_Mutation_p.Q584E|CTNNA1_uc011cyy.1_Missense_Mutation_p.Q564E|CTNNA1_uc003ldi.2_Missense_Mutation_p.Q385E|CTNNA1_uc003ldj.2_Missense_Mutation_p.Q687E|CTNNA1_uc003ldl.2_Missense_Mutation_p.Q317E	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	687					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GATTGCGGAACAGGTGGCCAG	0.483			NA											44	103					0	0	0.00874	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559724	140559724	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:140559724C>T	uc011dai.1	+	1	2295	c.2109C>T	c.(2107-2109)CTC>CTT	p.L703L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	703	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTCTTCCTCTTCTCGGTGC	0.677			NA											92	217					0	0	0.00361	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595072	140595072	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr5:140595072C>A	uc003lja.1	+	1	1564	c.1377C>A	c.(1375-1377)TTC>TTA	p.F459L		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	459	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.602			NA											92	224					4.64247e-43	1.40103e-42	0.00361	1	0
HLA-J	3137	broad.mit.edu	37	6	29977327	29977327	+	Silent	SNP	T	T	C	rs143365191	by1000genomes	TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:29977327T>C	uc003rtl.3	+	5	708	c.346T>C	c.(346-348)TTG>CTG	p.L116L	HLA-G_uc011dmb.1_3'UTR|NCRNA00171_uc011dme.1_Intron|HLA-J_uc003nou.3_RNA|HLA-J_uc003nov.3_RNA					Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:4694038).												0						GACAGCTGCCTTGTGTGGGAC	0.438			NA											3	105					0	0	0.004672	0	0
EYS	346007	broad.mit.edu	37	6	66115164	66115164	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:66115164C>G	uc011dxu.1	-	6	1497	c.959G>C	c.(958-960)TGC>TCC	p.C320S	EYS_uc003peq.2_Missense_Mutation_p.C320S|EYS_uc003per.1_Missense_Mutation_p.C320S	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	320					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TCCTTTTGGGCATTCATAAGT	0.383			NA											58	144					0	0	0.00361	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094060	143094060	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:143094060C>A	uc003qjd.2	-	5	2559	c.1816G>T	c.(1816-1818)GTG>TTG	p.V606L		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCGACTTCCACGTGGCCCTCC	0.532	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											53	74					9.16383e-17	2.24448e-16	0.00361	1	0
MAP3K4	4216	broad.mit.edu	37	6	161508846	161508846	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:161508846G>T	uc003qtn.2	+	10	2825	c.2683G>T	c.(2683-2685)GTA>TTA	p.V895L	MAP3K4_uc010kkc.1_Missense_Mutation_p.V895L|MAP3K4_uc003qto.2_Missense_Mutation_p.V895L|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.V348L	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	895					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TTCAGATGACGTACTCATCGA	0.493			NA											47	54					1.61004e-24	4.35354e-24	0.00361	1	0
THBS2	7058	broad.mit.edu	37	6	169634978	169634978	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:169634978G>C	uc003qwt.2	-	11	1750	c.1502C>G	c.(1501-1503)TCC>TGC	p.S501C		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	501	TSP type-1 3.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGACCACGGGGACCAGGGGCT	0.677	Esophageal Squamous(91;219 1934 18562 44706)		NA											3	75					0	0	0.004672	0	0
ABCB5	340273	broad.mit.edu	37	7	20778674	20778674	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:20778674C>G	uc003suw.3	+	15	2147	c.1601C>G	c.(1600-1602)TCC>TGC	p.S534C	ABCB5_uc010kuh.2_Missense_Mutation_p.S979C	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	534	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CCTGAATATTCCAAAGCCAAA	0.428			NA											16	35					0	0	0.004007	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23358808	23358808	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:23358808C>G	uc003swg.2	-	11	1535	c.1269G>C	c.(1267-1269)AAG>AAC	p.K423N	IGF2BP3_uc003swf.2_Missense_Mutation_p.K42N	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	423	KH 3.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						GCTGGCCCTGCTTGCCGATGA	0.458			NA											43	117					0	0	0.007835	0	0
HECW1	23072	broad.mit.edu	37	7	43360233	43360233	+	Splice_Site	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:43360233G>A	uc003tid.1	+	5	958	c.353_splice	c.e5-1	p.D118_splice	HECW1_uc011kbi.1_Splice_Site_p.D118_splice|HECW1_uc003tie.1_Splice_Site_p.D150_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TGGGAATATAGATGAGGTCTT	0.428			NA											24	59					0	0	0.00333	0	0
ANKIB1	54467	broad.mit.edu	37	7	91980320	91980320	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:91980320A>T	uc003ulw.2	+	8	1518	c.1142A>T	c.(1141-1143)TAT>TTT	p.Y381F		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	381	RING-type 1; atypical.						protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGCCCTGCATATGATTGCTTC	0.348			NA											13	35					0	0	0.001855	0	0
RELN	5649	broad.mit.edu	37	7	103202009	103202009	+	Silent	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:103202009G>T	uc003vca.2	-	36	5659	c.5499C>A	c.(5497-5499)ATC>ATA	p.I1833I	RELN_uc010liz.2_Silent_p.I1833I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1833					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCAGATTTGATGGTTTCAC	0.408	NSCLC(146;835 1944 15585 22231 52158)		NA											35	96					1.60099e-16	3.89304e-16	0.004878	1	0
SH2D4A	63898	broad.mit.edu	37	8	19221702	19221702	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:19221702C>A	uc003wzb.2	+	7	1162	c.826C>A	c.(826-828)CCC>ACC	p.P276T	SH2D4A_uc011kym.1_Missense_Mutation_p.P231T|SH2D4A_uc003wzc.2_Missense_Mutation_p.P276T	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	276						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		GCTGCAAAGCCCCTTGCGTGT	0.527			NA											30	90					9.04072e-19	2.29757e-18	0.003271	1	0
NRG1	3084	broad.mit.edu	37	8	32611924	32611924	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:32611924C>T	uc003xiv.2	+	8	1252	c.735C>T	c.(733-735)ACC>ACT	p.T245T	NRG1_uc011lbf.1_Silent_p.T242T|NRG1_uc010lvo.2_Silent_p.T242T|NRG1_uc003xiu.2_Silent_p.T250T|NRG1_uc003xiw.2_Silent_p.T242T|NRG1_uc003xit.2_Silent_p.T245T|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Silent_p.T199T|NRG1_uc010lvq.2_Silent_p.T182T|NRG1_uc011lbg.1_Silent_p.T91T|NRG1_uc011lbh.1_Silent_p.T88T|NRG1_uc003xiz.1_RNA|NRG1_uc003xja.2_Silent_p.T56T	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	245	Helical; Note=Internal signal sequence; (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GAGTGCTGACCATAACCGGCA	0.522			NA											28	83					0	0	0.00632	0	0
FAM110B	90362	broad.mit.edu	37	8	59059008	59059008	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:59059008G>C	uc003xtj.1	+	5	1099	c.219G>C	c.(217-219)GAG>GAC	p.E73D		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	73						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CCAAGCAGGAGCCCGTGAAGC	0.677			NA											30	61					0	0	0.002836	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767692	77767693	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:77767692_77767693GG>TT	uc003yav.2	+	10	8787_8788	c.8400_8401GG>TT	c.(8398-8403)CTGGAT>CTTTAT	p.D2801Y	ZFHX4_uc003yau.1_Missense_Mutation_p.D2846Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.D2801Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2801						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAAACTCTGGATACTCTGCC	0.49			NA								HNSCC(33;0.089)			35	66					0	0	0.004672	0	0
FAM135B	51059	broad.mit.edu	37	8	139164870	139164870	+	Silent	SNP	A	A	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:139164870A>G	uc003yuy.2	-	13	2019	c.1848T>C	c.(1846-1848)AGT>AGC	p.S616S	FAM135B_uc003yux.2_Silent_p.S517S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.S178S|FAM135B_uc003yvb.2_Silent_p.S178S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	616										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCCTAGAGTACTTAATTCAT	0.463			NA								HNSCC(54;0.14)			59	154					0	0	0.00361	0	0
MFSD3	113655	broad.mit.edu	37	8	145735371	145735371	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr8:145735371G>C	uc003zdi.1	+	1	820	c.655G>C	c.(655-657)GCA>CCA	p.A219P		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	219	Leu-rich.|Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CGTGTGGACGGCAGGCTTTGT	0.687			NA									OREG0019059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	0.006214	0	0
KDM4C	23081	broad.mit.edu	37	9	6986603	6986603	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr9:6986603C>T	uc003zkh.2	+	11	2194	c.1614C>T	c.(1612-1614)GGC>GGT	p.G538G	KDM4C_uc010mhu.2_Silent_p.G560G|KDM4C_uc011lmi.1_Silent_p.G538G|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.G538G|KDM4C_uc011lmk.1_Intron|KDM4C_uc011lml.1_Silent_p.G225G	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	538					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						ATGGGAATGGCCTTGAACCTG	0.468			NA											27	49					0	0	0.005443	0	0
POMT1	10585	broad.mit.edu	37	9	134385140	134385140	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr9:134385140C>T	uc004cav.2	+	7	752	c.550C>T	c.(550-552)CTG>TTG	p.L184L	POMT1_uc011mci.1_Silent_p.L146L|POMT1_uc004cax.2_Silent_p.L184L|POMT1_uc011mcj.1_Intron|POMT1_uc004cau.2_Silent_p.L184L|POMT1_uc004caw.2_Silent_p.L130L|POMT1_uc011mck.1_Silent_p.L67L|POMT1_uc011mcl.1_Silent_p.L32L|POMT1_uc011mcm.1_Silent_p.L154L|POMT1_uc011mcn.1_5'Flank	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	184	Helical; (Potential).				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		CCCTTTTTCTCTGAGCTGGTG	0.483			NA											61	148					0	0	0.00361	0	0
MXRA5	25878	broad.mit.edu	37	X	3240968	3240968	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:3240968G>C	uc004crg.3	-	5	2915	c.2758C>G	c.(2758-2760)CCA>GCA	p.P920A		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	920						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTAGGAGATGGTTCATAAGGC	0.493			NA											61	135					0	0	0.00361	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766230	27766230	+	Silent	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:27766230C>G	uc011mjy.1	+	1	1305	c.1218C>G	c.(1216-1218)GGC>GGG	p.G406G		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						AAAACAATGGCGTGCTCAAGA	0.438			NA											31	66					0	0	0.008361	0	0
FAM47B	170062	broad.mit.edu	37	X	34961951	34961951	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:34961951C>A	uc004ddi.1	+	1	1021	c.1003C>A	c.(1003-1005)CCT>ACT	p.P335T		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	335										ovary(3)|breast(1)	4						CTGCCTGGAACCTCCCAACAC	0.592			NA											39	89					6.5261e-18	1.62193e-17	0.00874	1	0
PRICKLE3	4007	broad.mit.edu	37	X	49035674	49035674	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:49035674G>A	uc004dmy.1	-	5	516	c.490C>T	c.(490-492)CGG>TGG	p.R164W	PRICKLE3_uc011mmv.1_Missense_Mutation_p.R96W|PRICKLE3_uc011mmw.1_Missense_Mutation_p.R83W|PRICKLE3_uc011mmx.1_Missense_Mutation_p.R126W|PRICKLE3_uc011mmy.1_Missense_Mutation_p.R151W	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	164	PET.						protein binding|zinc ion binding			breast(1)	1						TCCCGCTTCCGCTGCTGGCTA	0.612			NA											13	34					0	0	0.001855	0	0
SYP	6855	broad.mit.edu	37	X	49047923	49047923	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:49047923C>T	uc004dmz.1	-	6	929	c.913G>A	c.(913-915)GCA>ACA	p.A305T	SYP_uc011mmz.1_Missense_Mutation_p.A187T|SYP_uc004dna.1_Missense_Mutation_p.A299T	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	305	Cytoplasmic (Potential).|Repeats, Gly-rich.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				GAGGTGGGTGCACCCTGCGGG	0.647			NA											12	38					0	0	0.001855	0	0
CLCN5	1184	broad.mit.edu	37	X	49840596	49840596	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:49840596G>A	uc004dos.1	+	4	600	c.352G>A	c.(352-354)GAG>AAG	p.E118K	CLCN5_uc004dor.1_Missense_Mutation_p.E188K|CLCN5_uc004doq.1_Missense_Mutation_p.E188K|CLCN5_uc004dot.1_Missense_Mutation_p.E118K	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	118					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					CAAATGTCCAGAGTGGAATAG	0.388			NA											31	75					0	0	0.008361	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783622	54783622	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:54783622G>T	uc004dtj.2	-	8	2915	c.2885C>A	c.(2884-2886)CCA>CAA	p.P962Q		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	962	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						TGGAACTCCTGGCCTAGATGG	0.577			NA											44	68					1.31131e-34	3.8541e-34	0.003214	1	0
OGT	8473	broad.mit.edu	37	X	70782790	70782790	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:70782790C>A	uc004eaa.1	+	16	2288	c.2071C>A	c.(2071-2073)CAG>AAG	p.Q691K	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.Q681K|OGT_uc004eac.2_Missense_Mutation_p.Q552K|OGT_uc004ead.2_Missense_Mutation_p.Q310K	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	691					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					AGTTGCTGAGCAGTATTCCGA	0.438			NA											48	132					7.05377e-20	1.81998e-19	0.00361	1	0
FAM199X	139231	broad.mit.edu	37	X	103411604	103411604	+	Silent	SNP	C	C	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:103411604C>T	uc004elw.2	+	1	304	c.138C>T	c.(136-138)TTC>TTT	p.F46F		NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	46										ovary(1)	1						TCAGCGACTTCGGCTGCCAGC	0.657			NA											12	46					0	0	0.00499	0	0
COL4A5	1287	broad.mit.edu	37	X	107869498	107869498	+	Silent	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:107869498C>G	uc004enz.1	+	36	3367	c.3165C>G	c.(3163-3165)TCC>TCG	p.S1055S	COL4A5_uc011mso.1_Silent_p.S1055S|COL4A5_uc004eob.1_Silent_p.S663S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1055	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AACCTGGCTCCCCAGGATTAC	0.458			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				46	125					0	0	0.00361	0	0
UTP14A	10813	broad.mit.edu	37	X	129055497	129055497	+	Silent	SNP	C	C	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:129055497C>A	uc004euz.2	+	11	1310	c.1282C>A	c.(1282-1284)CGA>AGA	p.R428R	UTP14A_uc011mup.1_Silent_p.R376R|UTP14A_uc011muq.1_Silent_p.R374R|UTP14A_uc004eva.1_Silent_p.R134R	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	428					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TGAGGAAAGGCGATCCCTTAG	0.463			NA											34	82					9.65021e-13	2.2495e-12	0.002096	1	0
ATP11C	286410	broad.mit.edu	37	X	138871610	138871610	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:138871610G>T	uc004faz.2	-	13	1352	c.1253C>A	c.(1252-1254)ACT>AAT	p.T418N	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.T418N	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	418	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					GCTGTTTTCAGTGAGTGTTCC	0.343			NA											25	79					5.45024e-15	1.28824e-14	0.00333	1	0
SLITRK4	139065	broad.mit.edu	37	X	142718322	142718322	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:142718322G>T	uc004fbx.2	-	2	979	c.603C>A	c.(601-603)CAC>CAA	p.H201Q	SLITRK4_uc004fby.2_Missense_Mutation_p.H201Q	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	201	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGCCAATGTGTTCCAGAA	0.438			NA											51	117					6.08268e-21	1.5815e-20	0.00361	1	0
BCAP31	10134	broad.mit.edu	37	X	152967486	152967486	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:152967486C>G	uc011myz.1	-	7	834	c.678G>C	c.(676-678)TTG>TTC	p.L226F	BCAP31_uc011myy.1_Missense_Mutation_p.L138F|BCAP31_uc004fid.2_Missense_Mutation_p.L293F|BCAP31_uc011mza.1_Missense_Mutation_p.L226F|BCAP31_uc004fie.2_Missense_Mutation_p.L226F	NM_001139441	NP_001132913	P51572	BAP31_HUMAN	B-cell receptor-associated protein 31 isoform b	226	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|immune response|intracellular protein transport|vesicle-mediated transport	cytosol|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to plasma membrane	receptor binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTCCTCCAGCAAGCGGTCGT	0.587			NA											21	59					0	0	0.001882	0	0
MECP2	4204	broad.mit.edu	37	X	153296461	153296461	+	Missense_Mutation	SNP	C	C	A	rs61750242		TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chrX:153296461C>A	uc004fjv.2	-	4	1044	c.818G>T	c.(817-819)GGG>GTG	p.G273V	MECP2_uc004fjw.2_Missense_Mutation_p.G285V	NM_004992	NP_004983	P51608	MECP2_HUMAN	methyl CpG binding protein 2 isoform 1	273	A.T hook 2.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCACACTCCCCGGCTTTCG	0.607			NA											80	189					3.26865e-45	1.00437e-44	0.00361	1	0
RPL5	6125	broad.mit.edu	37	1	93306104	93306126	+	Splice_Site	DEL	TCAGATGGAGGAGATGTATAAGA	TCAGATGGAGGAGATGTATAAGA	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	TCAGATGGAGGAGATGTATAAGA	TCAGATGGAGGAGATGTATAAGA	-	-	TCAGATGGAGGAGATGTATAAGA	TCAGATGGAGGAGATGTATAAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr1:93306104_93306126delTCAGATGGAGGAGATGTATAAGA	uc001doz.2	+	7	784	c.706_splice	c.e7-1	p.M236_splice	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_Splice_Site|RPL5_uc001dpb.2_Splice_Site_p.M186_splice|RPL5_uc001dpd.2_Splice_Site_p.M37_splice|SNORA66_uc009wdi.1_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TTCCTTTGTTTCAGATGGAGGAGATGTATAAGAAAGCTCATGC	0.363			NA											11	162	---	---	---	---	NA	NA	NA	NA	NA
SLC22A12	116085	broad.mit.edu	37	11	64360272	64360273	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr11:64360272_64360273insA	uc001oam.1	+	2	1171_1172	c.424_425insA	c.(424-426)CATfs	p.H142fs	SLC22A12_uc009ypr.1_Frame_Shift_Ins_p.H142fs|SLC22A12_uc001oal.1_Translation_Start_Site|SLC22A12_uc009yps.1_Frame_Shift_Ins_p.H142fs|SLC22A12_uc001oan.1_Frame_Shift_Ins_p.H142fs|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	142					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GTGTGACTCTCATGCTCTGAAG	0.634			NA											85	224	---	---	---	---	NA	NA	NA	NA	NA
FMN1	342184	broad.mit.edu	37	15	33261122	33261123	+	In_Frame_Ins	INS	-	-	CAA			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr15:33261122_33261123insCAA	uc001zhf.3	-	4	2110_2111	c.2110_2111insTTG	c.(2110-2112)CCA>CTTGCA	p.704_704P>LA		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	927	FH1.|Pro-rich.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AAgtgggggtgggggtgggggt	0.421			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
SLC8A2	6543	broad.mit.edu	37	19	47935681	47935683	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr19:47935681_47935683delTCC	uc002pgx.2	-	9	2408_2410	c.2130_2132delGGA	c.(2128-2133)GAGGAC>GAC	p.E710del	SLC8A2_uc010xyq.1_In_Frame_Del_p.E466del|SLC8A2_uc010xyr.1_In_Frame_Del_p.E173del|SLC8A2_uc010ele.2_In_Frame_Del_p.E710del	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	710	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCGGGACCCGTCCTCCTCCTCCT	0.616			NA											7	244	---	---	---	---	NA	NA	NA	NA	NA
BBS7	55212	broad.mit.edu	37	4	122749557	122749557	+	Frame_Shift_Del	DEL	T	T	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr4:122749557delT	uc003ied.2	-	17	2064	c.1890delA	c.(1888-1890)AAAfs	p.K630fs	BBS7_uc003iee.1_Frame_Shift_Del_p.K630fs	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	630					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						ATGTACTTACTTTTAAAGCAT	0.323			NA							Bardet-Biedl_syndrome				35	102	---	---	---	---	NA	NA	NA	NA	NA
PHACTR2	9749	broad.mit.edu	37	6	144081695	144081696	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr6:144081695_144081696insA	uc003qjq.3	+	5	709_710	c.579_580insA	c.(577-582)ATTAAAfs	p.I193fs	PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Frame_Shift_Ins_p.I204fs|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	193_194							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGCCTCCCATTAAAAAAAATAC	0.569	Pancreas(12;292 433 7358 48260 52635)|Ovarian(20;501 618 3485 36581 49208)		NA											8	113	---	---	---	---	NA	NA	NA	NA	NA
C7orf25	79020	broad.mit.edu	37	7	42950377	42950377	+	Frame_Shift_Del	DEL	T	T	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr7:42950377delT	uc003thw.2	-	2	587	c.123delA	c.(121-123)AAAfs	p.K41fs	C7orf25_uc010kxq.2_Frame_Shift_Del_p.K41fs|C7orf25_uc003thx.3_Frame_Shift_Del_p.K99fs|C7orf25_uc010kxr.2_Frame_Shift_Del_p.K99fs	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	41										skin(1)	1						CTGCCTTCAATTTGCTGCACA	0.423			NA											108	253	---	---	---	---	NA	NA	NA	NA	NA
TBC1D2	55357	broad.mit.edu	37	9	100965613	100965614	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	AT	AT	-	-	AT	AT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr9:100965613_100965614delAT	uc011lvb.1	-	10	2407_2408	c.2227_2228delAT	c.(2227-2229)ATCfs	p.I743fs	TBC1D2_uc004ayp.2_Frame_Shift_Del_p.I283fs|TBC1D2_uc004ayq.2_Frame_Shift_Del_p.I743fs|TBC1D2_uc004ayr.2_Frame_Shift_Del_p.I525fs|TBC1D2_uc004ayo.3_Frame_Shift_Del_p.I743fs	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	743	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGCGGGCATGATGGTCTCCACA	0.614			NA											78	205	---	---	---	---	NA	NA	NA	NA	NA
TLR4	7099	broad.mit.edu	37	9	120476595	120476595	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6849-01A-11D-1945-08	TCGA-91-6849-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e35f07c4-bc27-4f85-bc74-acb00e8445bd	21fa02d1-a56c-4fe0-80eb-780083e6a889	g.chr9:120476595delG	uc004bjz.2	+	3	2480	c.2189delG	c.(2188-2190)AGCfs	p.S730fs	TLR4_uc004bka.2_Frame_Shift_Del_p.S690fs|TLR4_uc004bkb.2_Frame_Shift_Del_p.S530fs	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	730	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTCCATAAAAGCCGAAAGGTG	0.493			NA											52	139	---	---	---	---	NA	NA	NA	NA	NA
