Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NPPB	4879	broad.mit.edu	37	1	11918520	11918520	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:11918520G>A	uc001atj.2	-	2	241	c.139C>T	c.(139-141)CGC>TGC	p.R47C		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	47					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	AAATGGTTGCGCTGCTCCTGC	0.637			NA											7	17					0	0	0.001984	0	0
SPEN	23013	broad.mit.edu	37	1	16262465	16262465	+	Missense_Mutation	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:16262465A>C	uc001axk.1	+	11	9934	c.9730A>C	c.(9730-9732)ACC>CCC	p.T3244P	SPEN_uc010obp.1_Missense_Mutation_p.T3203P	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3244	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGCTgcccccacccccacccc	0.418			NA											5	13					0	0	0.006122	0	0
MST1P9	11223	broad.mit.edu	37	1	17085872	17085872	+	Missense_Mutation	SNP	A	A	G	rs1806514	by1000genomes	TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:17085872A>G	uc010ock.1	-	8	949	c.949T>C	c.(949-951)TGG>CGG	p.W317R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TCGAGGTTCCAGCAGAAGTTC	0.662			NA											4	24					0	0	0.009096	0	0
YTHDF2	51441	broad.mit.edu	37	1	29069381	29069381	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:29069381C>T	uc001brc.2	+	4	1096	c.599C>T	c.(598-600)GCA>GTA	p.A200V	YTHDF2_uc001brd.2_Missense_Mutation_p.A197V|YTHDF2_uc010ofx.1_Missense_Mutation_p.A150V|YTHDF2_uc001bre.2_Missense_Mutation_p.A150V	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	200					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGAAGTTGCAAGCAATGTT	0.483			NA											4	26					0	0	0.000602	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237928	33237928	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:33237928C>T	uc001bvv.2	+	6	3107	c.2971C>T	c.(2971-2973)CCT>TCT	p.P991S	KIAA1522_uc001bvu.1_Missense_Mutation_p.P1050S|KIAA1522_uc010ohm.1_Missense_Mutation_p.P1002S|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	991	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCTTACTGCTCCTCCCACCAA	0.652			NA											19	79					0	0	0.00278	0	0
TMEM59	9528	broad.mit.edu	37	1	54509117	54509117	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:54509117C>A	uc001cwp.2	-	4	722	c.472G>T	c.(472-474)GCA>TCA	p.A158S	TMEM59_uc001cwn.2_Missense_Mutation_p.A21S|TMEM59_uc001cwo.2_Missense_Mutation_p.A21S|TMEM59_uc001cwq.2_Missense_Mutation_p.A158S|TMEM59_uc001cwr.2_Missense_Mutation_p.A91S|TMEM59_uc001cws.1_Missense_Mutation_p.A169S	NM_004872	NP_004863	Q9BXS4	TMM59_HUMAN	thymic dendritic cell-derived factor 1	158	Extracellular (Potential).					Golgi membrane|integral to membrane					0						AAGCTCTGTGCGGAGTCCATC	0.393			NA											9	70					2.17888e-05	2.56099e-05	0.006214	1	0
USP1	7398	broad.mit.edu	37	1	62908936	62908936	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:62908936A>G	uc001daj.1	+	5	831	c.503A>G	c.(502-504)GAG>GGG	p.E168G	USP1_uc001dak.1_Missense_Mutation_p.E168G|USP1_uc001dal.1_Missense_Mutation_p.E168G	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	168					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		TTAAATCCAGAGAAATATACT	0.368	Ovarian(122;1846 2315 3982 19504)		NA											4	49					0	0	0.000602	0	0
C1orf173	127254	broad.mit.edu	37	1	75038164	75038164	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:75038164C>T	uc001dgg.2	-	14	3449	c.3230G>A	c.(3229-3231)AGA>AAA	p.R1077K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1077	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CACCTCTTCTCTCTCAGAGTC	0.408			NA											6	168					0	0	0.001984	0	0
FNBP1L	54874	broad.mit.edu	37	1	93998552	93998552	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:93998552G>A	uc001dpw.2	+	8	713	c.713G>A	c.(712-714)CGC>CAC	p.R238H	FNBP1L_uc001dpv.2_Missense_Mutation_p.R238H|FNBP1L_uc010otk.1_Missense_Mutation_p.R58H	NM_001024948	NP_001020119	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like isoform 1	238	Induction of membrane tubulation (By similarity).				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		GACTCAGAACGCAAAGTTATT	0.323			NA											3	66					0	0	0.004672	0	0
WARS2	10352	broad.mit.edu	37	1	119575957	119575957	+	Silent	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:119575957T>A	uc001ehn.2	-	6	688	c.660A>T	c.(658-660)CTA>CTT	p.L220L	WARS2_uc010oxf.1_Silent_p.L126L|WARS2_uc001ehm.2_3'UTR|WARS2_uc010oxg.1_Silent_p.L163L|WARS2_uc010oxh.1_Missense_Mutation_p.T192S	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	220					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AAGGATCACGTAGGGATTTTA	0.428			NA											41	152					0	0	0.01441	0	0
LCE3E	353145	broad.mit.edu	37	1	152538434	152538434	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:152538434C>A	uc001faa.2	-	2	307	c.251G>T	c.(250-252)TGC>TTC	p.C84F		NM_178435	NP_848522	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	84					keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		ACCGTGGCAGCAGCCAGAGCC	0.617			NA											36	129					1.57019e-19	2.26886e-19	0.007835	1	0
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:153907309C>T	uc001fdd.1	-	18	3101	c.2700G>A	c.(2698-2700)CAG>CAA	p.Q900Q	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.468			NA											4	69					0	0	0.009096	0	0
PYGO2	90780	broad.mit.edu	37	1	154931485	154931485	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:154931485C>T	uc001fft.2	-	3	1197	c.991G>A	c.(991-993)GGT>AGT	p.G331S	PBXIP1_uc001ffr.2_5'Flank|PBXIP1_uc001ffs.2_5'Flank|PBXIP1_uc010pep.1_5'Flank	NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	331	PHD-type.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CGACAGGCACCACATGGGTAC	0.642	NSCLC(87;357 1460 1955 21029 23522)		NA											7	51					0	0	0.004482	0	0
CD1A	909	broad.mit.edu	37	1	158225793	158225793	+	Splice_Site	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:158225793G>C	uc001frt.2	+	3	859	c.326_splice	c.e3-1	p.Y109_splice		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor						antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CATAACCCCAGATCCTTTTGA	0.423			NA											6	101					0	0	0.001984	0	0
OR6K2	81448	broad.mit.edu	37	1	158670335	158670335	+	Silent	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:158670335A>T	uc001fsu.1	-	1	108	c.108T>A	c.(106-108)GCT>GCA	p.A36A		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CAACAATGAAAGCATAGATGA	0.448			NA											10	87					0	0	0.006214	0	0
GLUL	2752	broad.mit.edu	37	1	182355392	182355392	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:182355392C>T	uc001gpa.1	-	4	686	c.474G>A	c.(472-474)CAG>CAA	p.Q158Q	GLUL_uc010pnt.1_5'Flank|GLUL_uc001gpb.1_Silent_p.Q158Q|GLUL_uc001gpc.1_Silent_p.Q158Q|GLUL_uc001gpd.1_Silent_p.Q158Q	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	158					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	GAGACTTACCCTGGGGCCCTG	0.552			NA											26	94					0	0	0.004656	0	0
FAM5C	339479	broad.mit.edu	37	1	190234090	190234090	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:190234090C>A	uc001gse.1	-	4	755	c.523G>T	c.(523-525)GAG>TAG	p.E175*	FAM5C_uc010pot.1_Nonsense_Mutation_p.E73*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	175						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGTAGCGTCTCCAGAGTGACC	0.483			NA											8	103					0.000157383	0.000179622	0.00308	1	0
CR1	1378	broad.mit.edu	37	1	207790041	207790041	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:207790041G>A	uc001hfy.2	+	33	5573	c.5433G>A	c.(5431-5433)ATG>ATA	p.M1811I	CR1_uc001hfx.2_Missense_Mutation_p.M2261I	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1811	Sushi 28.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						ACAGAGGGATGACCTTCAACC	0.522			NA											84	127					0	0	0.01441	0	0
PROX1	5629	broad.mit.edu	37	1	214169983	214169983	+	Silent	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:214169983T>C	uc001hkh.2	+	2	377	c.105T>C	c.(103-105)GCT>GCC	p.A35A	PROX1_uc001hkg.1_Silent_p.A35A	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	35					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CATTTTTTGCTAAGGCAAGAG	0.478			NA											6	82					0	0	0.001168	0	0
USH2A	7399	broad.mit.edu	37	1	216380727	216380727	+	Silent	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:216380727A>C	uc001hku.1	-	16	3591	c.3204T>G	c.(3202-3204)TCT>TCG	p.S1068S	USH2A_uc001hkv.2_Silent_p.S1068S	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1068	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GATTGATAGCAGAAGAACTTT	0.418			NA								HNSCC(13;0.011)			7	120					0	0	0.004482	0	0
ACTA1	58	broad.mit.edu	37	1	229567839	229567839	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:229567839G>A	uc001htm.2	-	5	815	c.710C>T	c.(709-711)TCC>TTC	p.S237F		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	237					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	CTTTTCCAGGGAGGAGGAGGA	0.637			NA											3	24					0	0	0.004672	0	0
OR2L2	26246	broad.mit.edu	37	1	248202245	248202245	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248202245C>G	uc001idw.2	+	1	772	c.676C>G	c.(676-678)CGC>GGC	p.R226G	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGCTGTCTACCGCATGCACTC	0.488			NA											23	191					0	0	0.003954	0	0
OR2M5	127059	broad.mit.edu	37	1	248308491	248308491	+	Silent	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248308491C>G	uc010pze.1	+	1	42	c.42C>G	c.(40-42)CTC>CTG	p.L14L		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ACTTCATCCTCCTGGGAATCT	0.438			NA											36	288					0	0	0.01441	0	0
OR2M2	391194	broad.mit.edu	37	1	248344224	248344224	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248344224G>T	uc010pzf.1	+	1	937	c.937G>T	c.(937-939)GAG>TAG	p.E313*		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTCTGAGAGTGAGTTACCTCA	0.388			NA											24	263					1.85244e-09	2.43133e-09	0.00333	1	0
OR2M3	127062	broad.mit.edu	37	1	248366612	248366612	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248366612G>T	uc010pzg.1	+	1	243	c.243G>T	c.(241-243)ATG>ATT	p.M81I		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACCCAAGATGGCCTTCAACT	0.512			NA											138	312					1.27947e-65	1.9011e-65	0.01441	1	0
OR2M3	127062	broad.mit.edu	37	1	248367064	248367064	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248367064A>T	uc010pzg.1	+	1	695	c.695A>T	c.(694-696)GAG>GTG	p.E232V		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGATCTGGAGAGGGTCGTCGC	0.448			NA											6	365					0	0	0.001984	0	0
OR2T12	127064	broad.mit.edu	37	1	248458039	248458039	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr1:248458039G>C	uc010pzj.1	-	1	842	c.842C>G	c.(841-843)CCT>CGT	p.P281R		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTAGTAAAGGGGTGAACAT	0.458			NA											4	176					0	0	0.000602	0	0
IL2RA	3559	broad.mit.edu	37	10	6067883	6067883	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:6067883C>G	uc001iiz.1	-	2	329	c.170G>C	c.(169-171)AGA>ACA	p.R57T	IL2RA_uc009xih.1_Missense_Mutation_p.R57T|IL2RA_uc001ija.1_Missense_Mutation_p.R19T	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	57	Sushi 1.|Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GCTTTTTATTCTGCGGAAACC	0.498			NA											4	83					0	0	0.009096	0	0
CUBN	8029	broad.mit.edu	37	10	16967685	16967685	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:16967685C>A	uc001ioo.2	-	42	6412	c.6360G>T	c.(6358-6360)TGG>TGT	p.W2120C		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2120	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCAGGACGTGCCAAGAACAGT	0.502			NA											15	64					1.67942e-08	2.15925e-08	0.006122	1	0
CUBN	8029	broad.mit.edu	37	10	17110211	17110211	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:17110211G>T	uc001ioo.2	-	21	2912	c.2860C>A	c.(2860-2862)CAC>AAC	p.H954N		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	954	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGATACCGTGGGGGTAGACA	0.368			NA											16	185					5.01169e-05	5.8254e-05	0.00499	1	0
GPR158	57512	broad.mit.edu	37	10	25885651	25885651	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:25885651G>T	uc001isj.2	+	10	2138	c.2078G>T	c.(2077-2079)GGA>GTA	p.G693V	GPR158_uc001isk.2_Missense_Mutation_p.G68V	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	693	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GGCCGATCTGGATCCTACCTG	0.438			NA											4	81					0.00024832	0.000280361	0.009096	1	0
NRP1	8829	broad.mit.edu	37	10	33502610	33502610	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:33502610C>G	uc001iwx.3	-	9	1841	c.1318G>C	c.(1318-1320)GGA>CGA	p.G440R	NRP1_uc001iwv.3_Missense_Mutation_p.G440R|NRP1_uc009xlz.2_Missense_Mutation_p.G440R|NRP1_uc001iww.3_Missense_Mutation_p.G259R|NRP1_uc001iwy.3_Missense_Mutation_p.G440R|NRP1_uc001iwz.2_Missense_Mutation_p.G440R|NRP1_uc001ixa.2_Missense_Mutation_p.G440R|NRP1_uc001ixb.1_Missense_Mutation_p.G440R|NRP1_uc001ixc.1_Missense_Mutation_p.G440R	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	440	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	GAAATAAGTCCAGACACCATA	0.458	Melanoma(104;886 1489 44640 45944 51153)		NA											12	82					0	0	0.00245	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43691988	43691988	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:43691988C>T	uc001jap.1	-	12	1438	c.1357G>A	c.(1357-1359)GTC>ATC	p.V453I	RASGEF1A_uc001jao.1_Missense_Mutation_p.V461I	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	453	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						AAGGAGGCGACGAAGAGAGCT	0.562			NA											10	110					0	0	0.008291	0	0
ZNF487	642819	broad.mit.edu	37	10	43971290	43971290	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:43971290C>T	uc010qfb.1	+	2	259	c.32C>T	c.(31-33)TCA>TTA	p.S11L		NR_026693				SubName: Full=cDNA FLJ52643, weakly similar to Zinc finger protein 11B;												0						CTCCTCCTCTCAGTGGGTAAG	0.458			NA											4	17					0	0	0.009096	0	0
PRKG1	5592	broad.mit.edu	37	10	52912943	52912944	+	Missense_Mutation	DNP	GA	GA	AT			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:52912943_52912944GA>AT	uc001jjm.2	+	2	480_481	c.286_287GA>AT	c.(286-288)GAA>ATA	p.E96I	PRKG1_uc001jjn.2_Missense_Mutation_p.E111I|PRKG1_uc001jjo.2_Missense_Mutation_p.E111I|PRKG1_uc010qhp.1_Missense_Mutation_p.E96I	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	96	Dimerization.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TCTTATAAAGGAAGCTATCCTT	0.455			NA											42	103					0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55755468	55755468	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:55755468G>T	uc001jju.1	-	21	3204	c.2809C>A	c.(2809-2811)CCG>ACG	p.P937T	PCDH15_uc010qhq.1_Missense_Mutation_p.P942T|PCDH15_uc010qhr.1_Missense_Mutation_p.P937T|PCDH15_uc010qhs.1_Missense_Mutation_p.P949T|PCDH15_uc010qht.1_Missense_Mutation_p.P944T|PCDH15_uc010qhu.1_Missense_Mutation_p.P937T|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P937T|PCDH15_uc010qhw.1_Missense_Mutation_p.P900T|PCDH15_uc010qhx.1_Missense_Mutation_p.P866T|PCDH15_uc010qhy.1_Missense_Mutation_p.P942T|PCDH15_uc010qhz.1_Missense_Mutation_p.P937T|PCDH15_uc010qia.1_Missense_Mutation_p.P915T|PCDH15_uc010qib.1_Missense_Mutation_p.P915T|PCDH15_uc001jjw.2_Missense_Mutation_p.P937T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	937	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTGCATCCGGAGCCACCATC	0.398			NA								HNSCC(58;0.16)			12	86					1.08611e-07	1.35763e-07	0.010729	1	0
ANXA7	310	broad.mit.edu	37	10	75147496	75147496	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:75147496T>C	uc001jtz.2	-	8	723	c.650A>G	c.(649-651)AAT>AGT	p.N217S	ANXA7_uc001jua.2_Missense_Mutation_p.N195S|ANXA7_uc001jub.2_Missense_Mutation_p.N155S|ANXA7_uc010qki.1_Missense_Mutation_p.N105S|ANXA7_uc009xre.2_Missense_Mutation_p.N124S|ANXA7_uc009xrf.1_Missense_Mutation_p.N137S	NM_004034	NP_004025	P20073	ANXA7_HUMAN	annexin VII isoform 2	217	Annexin 1.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CCTCTGATCATTGGAACGGTT	0.463			NA											51	148					0	0	0.01441	0	0
SEC24C	9632	broad.mit.edu	37	10	75510968	75510968	+	Missense_Mutation	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:75510968A>C	uc001juw.2	+	4	454	c.275A>C	c.(274-276)CAG>CCG	p.Q92P	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Intron|SEC24C_uc001jux.2_Missense_Mutation_p.Q92P|SEC24C_uc010qko.1_Intron|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	92					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					GGAGATGTACAGAATGGGCCA	0.448			NA											4	44					0	0	0.009096	0	0
BTAF1	9044	broad.mit.edu	37	10	93757446	93757446	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:93757446G>C	uc001khr.2	+	25	3696	c.3598G>C	c.(3598-3600)GAC>CAC	p.D1200H		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1200	HEAT 8.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TGATCAGACAGACAGTGTGAG	0.378			NA											11	86					0	0	0.010729	0	0
MKI67	4288	broad.mit.edu	37	10	129913773	129913773	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:129913773C>A	uc001lke.2	-	7	1094	c.899G>T	c.(898-900)GGC>GTC	p.G300V	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	300					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CACAGCGTGGCCGCTCCCACC	0.532			NA											5	67					2.0095e-06	2.43458e-06	0.001984	1	0
MGMT	4255	broad.mit.edu	37	10	131334541	131334541	+	Missense_Mutation	SNP	C	C	T	rs141095230	byFrequency	TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr10:131334541C>T	uc001lkh.2	+	2	144	c.118C>T	c.(118-120)CGC>TGC	p.R40C		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	9										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		TGAAATGAAACGCACCACACT	0.458			NA						Direct_reversal_of_damage					25	76					0	0	0.009535	0	0
ANO9	338440	broad.mit.edu	37	11	418979	418979	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:418979C>A	uc001lpi.2	-	21	2030	c.1945G>T	c.(1945-1947)GGC>TGC	p.G649C	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.G342C|ANO9_uc010qvv.1_Missense_Mutation_p.G505C	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	649	Extracellular (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTGACGTAGCCCTTGAGGCAG	0.617			NA											7	148					8.12818e-05	9.41315e-05	0.001984	1	0
MUC6	4588	broad.mit.edu	37	11	1018718	1018718	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:1018718G>A	uc001lsw.2	-	31	4134	c.4083C>T	c.(4081-4083)GGC>GGT	p.G1361G		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1361	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGGACGTGGGCCTGTCGTCT	0.542			NA											13	118					0	0	0.001855	0	0
MUC5B	727897	broad.mit.edu	37	11	1155162	1155162	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:1155162C>A	uc009ycr.1	+	4	296	c.170C>A	c.(169-171)GCG>GAG	p.A57E		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCGTGGGGCGACTGTCTTC	0.672			NA											6	23					0.000157383	0.000179622	0.00308	1	0
IGF2	3481	broad.mit.edu	37	11	2154748	2154748	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:2154748G>A	uc009yde.2	-	3	408	c.305C>T	c.(304-306)CCG>CTG	p.P102L	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.P102L|IGF2_uc009ydf.2_Missense_Mutation_p.P158L|IGF2_uc001lvh.2_Missense_Mutation_p.P102L|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	102					glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GACCCTCACCGGAAGCACGGT	0.642			NA											4	27					0	0	0.009096	0	0
CD81	975	broad.mit.edu	37	11	2398821	2398821	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:2398821C>T	uc001lwf.1	+	1	275	c.42C>T	c.(40-42)CTC>CTT	p.L14L	uc001lwe.2_RNA	NM_004356	NP_004347	P60033	CD81_HUMAN	CD81 antigen	14	Helical; (Potential).				activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding				0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGTACCTGCTCTTCGTCTTCA	0.463			NA											9	29					0	0	0.008291	0	0
ZNF195	7748	broad.mit.edu	37	11	3380678	3380678	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:3380678C>T	uc001lxt.2	-	6	1738	c.1560G>A	c.(1558-1560)AAG>AAA	p.K520K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K497K|ZNF195_uc001lxs.2_Silent_p.K448K|ZNF195_uc010qxr.1_Silent_p.K501K|ZNF195_uc009ydz.2_Silent_p.K475K|ZNF195_uc001lxu.2_Silent_p.K452K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGCTTCTCTCCAG	0.403			NA											5	194					0	0	0.000602	0	0
OR52M1	119772	broad.mit.edu	37	11	4566498	4566498	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:4566498C>G	uc010qyf.1	+	1	78	c.78C>G	c.(76-78)CAC>CAG	p.H26Q		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCCCTACACGTCTGGCTCT	0.537			NA											4	86					0	0	0.001168	0	0
OR52A5	390054	broad.mit.edu	37	11	5153137	5153137	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:5153137C>T	uc010qyx.1	-	1	736	c.736G>A	c.(736-738)GCC>ACC	p.A246T		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAATGTGGGCAATGCATGTA	0.398			NA											18	66					0	0	0.007413	0	0
NLRP10	338322	broad.mit.edu	37	11	7981425	7981425	+	Silent	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:7981425A>T	uc001mfv.1	-	2	1751	c.1734T>A	c.(1732-1734)GGT>GGA	p.G578G		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	578							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCATCTGAATACCTTTTACCA	0.343			NA											8	33					0	0	0.004482	0	0
CKAP5	9793	broad.mit.edu	37	11	46831310	46831310	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:46831310C>A	uc001ndi.1	-	6	855	c.745G>T	c.(745-747)GGT>TGT	p.G249C	CKAP5_uc009ylg.1_Missense_Mutation_p.G135C|CKAP5_uc001ndj.1_Missense_Mutation_p.G249C	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	249					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GCATCTCCACCAGCAGACTGT	0.428	Ovarian(4;85 273 2202 4844 13323)		NA											41	218					1.93748e-29	2.86529e-29	0.01441	1	0
AGBL2	79841	broad.mit.edu	37	11	47681733	47681733	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:47681733A>G	uc001ngg.2	-	18	2801	c.2701T>C	c.(2701-2703)TAC>CAC	p.Y901H	AGBL2_uc001ngf.2_RNA	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	901					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						ACCTACGGGTATGTGTATATG	0.512			NA											19	63					0	0	0.010504	0	0
OR4X2	119764	broad.mit.edu	37	11	48266905	48266905	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:48266905A>G	uc001ngs.1	+	1	250	c.250A>G	c.(250-252)ATA>GTA	p.I84V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGGAAAGTCATATCTTGGTG	0.502			NA											11	124					0	0	0.010729	0	0
OR4A15	81328	broad.mit.edu	37	11	55136267	55136267	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:55136267T>A	uc010rif.1	+	1	908	c.908T>A	c.(907-909)CTA>CAA	p.L303Q		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	303	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACTGTAGTTCTAACTTTTATA	0.383			NA											54	216					0	0	0.01441	0	0
OR5I1	10798	broad.mit.edu	37	11	55703101	55703101	+	Missense_Mutation	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:55703101A>C	uc010ris.1	-	1	776	c.776T>G	c.(775-777)TTT>TGT	p.F259C		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAGTAAATAAAGAGGAGAGT	0.433			NA											5	29					0	0	0.001168	0	0
OR7E5P	219445	broad.mit.edu	37	11	55747330	55747330	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:55747330C>A	uc010riu.1	-	4	682	c.127G>T	c.(127-129)GCC>TCC	p.A43S		NR_027688				SubName: Full=HCG2036849; SubName: Full=Seven transmembrane helix receptor;												0						GGGACCGTGGCCGAGGTGAAA	0.532			NA											7	27					0.000157383	0.000179622	0.00308	1	0
FCHSD2	9873	broad.mit.edu	37	11	72712069	72712069	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:72712069G>A	uc009ytl.2	-	5	574	c.353C>T	c.(352-354)ACA>ATA	p.T118I	FCHSD2_uc010rrg.1_Intron|FCHSD2_uc001oth.3_Missense_Mutation_p.T62I|FCHSD2_uc001oti.2_Missense_Mutation_p.T77I	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	118							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			GCTTCTCACTGTCCTTGCAGG	0.363			NA											6	20					0	0	0.001168	0	0
FZD4	8322	broad.mit.edu	37	11	86662523	86662523	+	Silent	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:86662523T>G	uc001pce.2	-	2	1581	c.1275A>C	c.(1273-1275)ACA>ACC	p.T425T	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	425	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGTCTGTCTTTGTCCCATCCT	0.413			NA											27	109					0	0	0.004656	0	0
TYR	7299	broad.mit.edu	37	11	88911689	88911689	+	Missense_Mutation	SNP	G	G	A	rs61754361		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:88911689G>A	uc001pcs.2	+	1	650	c.568G>A	c.(568-570)GGG>AGG	p.G190R		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	190	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TGCACTGCTTGGGGGATCTGA	0.423			NA							Oculocutaneous_Albinism				13	147					0	0	0.00245	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335702	117335702	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:117335702G>A	uc001prh.1	-	17	3403	c.3401C>T	c.(3400-3402)ACG>ATG	p.T1134M		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1074	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGAGGGCCCCGTGCCAGCCCG	0.622			NA											10	73					0	0	0.010729	0	0
OR8B3	390271	broad.mit.edu	37	11	124266624	124266624	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:124266624C>A	uc010saj.1	-	1	624	c.624G>T	c.(622-624)ATG>ATT	p.M208I	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AACTGGGTACCATGATATTAA	0.418			NA											4	173					0.00909568	0.00974537	0.009096	1	0
SIAE	54414	broad.mit.edu	37	11	124509640	124509640	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr11:124509640T>C	uc001qan.2	-	8	1203	c.1090A>G	c.(1090-1092)ATG>GTG	p.M364V		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	364						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CAGAGATCCATAGCTACAGCC	0.468			NA											14	131					0	0	0.003163	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662435	662435	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:662435A>T	uc001qii.1	+	14	1346	c.1346A>T	c.(1345-1347)AAT>ATT	p.N449I	B4GALNT3_uc001qij.1_Missense_Mutation_p.N352I|B4GALNT3_uc001qik.1_5'UTR	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	449	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AACAACCAGAATGCCAGGATG	0.547			NA											28	188					0	0	0.007291	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1955760	1955760	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:1955760C>T	uc001qjp.2	-	24	2573	c.2342G>A	c.(2341-2343)AGG>AAG	p.R781K	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.R645K|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	781	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCCAACCCACCTGTCGGAGAC	0.662	Colon(2;101 179 21030 23310 28141)		NA											3	14					0	0	0.009096	0	0
VWF	7450	broad.mit.edu	37	12	6103686	6103686	+	Silent	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:6103686T>G	uc001qnn.1	-	36	6401	c.6151A>C	c.(6151-6153)AGA>CGA	p.R2051R	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2051	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TGATTGAATCTGACCTCATGC	0.473			NA											23	129					0	0	0.00333	0	0
PRB3	5544	broad.mit.edu	37	12	11421043	11421043	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:11421043G>A	uc001qzs.2	-	3	178	c.140C>T	c.(139-141)CCC>CTC	p.P47L	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	47	Pro-rich.			PQRTPPP -> SQGPPPR (in Ref. 1; CAA30728).		extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGTACGTTGGGGCTGGTTTCC	0.572			NA											16	219					0	0	0.003163	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061538	13061538	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:13061538C>T	uc001rba.2	+	2	1005	c.355C>T	c.(355-357)CTG>TTG	p.L119L	GPRC5A_uc001raz.2_Silent_p.L119L	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	119	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TGCTGTCAGTCTGACCAAGCT	0.567			NA											6	259					0	0	0.001168	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21196312	21196312	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:21196312T>C	uc010sin.1	+	6	631	c.631T>C	c.(631-633)TGG>CGG	p.W211R	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.W258R	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	211						membrane	transporter activity				0						GGTTGGAGCTTGGTGGCTTGG	0.373			NA											32	152					0	0	0.006999	0	0
ITPR2	3709	broad.mit.edu	37	12	26807047	26807047	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:26807047C>A	uc001rhg.2	-	21	3019	c.2602G>T	c.(2602-2604)GCT>TCT	p.A868S		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	868	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGATTCCGAGCCAAGTGGACC	0.368			NA											13	44					2.68362e-12	3.74044e-12	0.013537	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43846373	43846373	+	Missense_Mutation	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:43846373T>G	uc010skx.1	-	13	1886	c.1886A>C	c.(1885-1887)CAT>CCT	p.H629P		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	629	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GATGTCCAAATGTTTACCATT	0.408			NA											15	37					0	0	0.00499	0	0
PRPF40B	25766	broad.mit.edu	37	12	50029039	50029039	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:50029039C>A	uc001rur.1	+	12	1157	c.1093C>A	c.(1093-1095)CGC>AGC	p.R365S	PRPF40B_uc001rup.1_Missense_Mutation_p.R387S|PRPF40B_uc001ruq.1_Missense_Mutation_p.R359S|PRPF40B_uc001rus.1_Missense_Mutation_p.R308S	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	365					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CTCCACCACCCGCTACCGGTC	0.592			NA											27	49					3.17567e-06	3.80356e-06	0.008361	1	0
OR6C76	390326	broad.mit.edu	37	12	55820504	55820504	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:55820504C>G	uc010spm.1	+	1	467	c.467C>G	c.(466-468)CCA>CGA	p.P156R		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATTTTTCCACCACTGGCCATG	0.443			NA											7	124					0	0	0.00308	0	0
IL23A	51561	broad.mit.edu	37	12	56733603	56733603	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:56733603C>T	uc001sla.2	+	3	556	c.390C>T	c.(388-390)GGC>GGT	p.G130G		NM_016584	NP_057668	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19 precursor	130					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity				0						CCCTACTGGGCCTCAGCCAAC	0.542			NA											10	88					0	0	0.008291	0	0
GEFT	115557	broad.mit.edu	37	12	58008537	58008537	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:58008537G>T	uc001spb.2	+	9	1342	c.882G>T	c.(880-882)CGG>CGT	p.R294R	GEFT_uc009zpy.2_Silent_p.R333R|GEFT_uc001soz.1_Silent_p.R168R|GEFT_uc001spa.2_Silent_p.R188R|uc001spc.2_Intron|GEFT_uc001spd.2_5'UTR	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	294	Important for binding to Rho GTPases.|DH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					CTGTGCAGCGGATCATGAAAT	0.602			NA											11	17					2.80697e-09	3.66887e-09	0.010729	1	0
RAB3IP	117177	broad.mit.edu	37	12	70149282	70149282	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:70149282G>A	uc001svp.2	+	2	589	c.142G>A	c.(142-144)GAG>AAG	p.E48K	RAB3IP_uc001svl.1_Missense_Mutation_p.E32K|RAB3IP_uc001svm.2_Missense_Mutation_p.E32K|RAB3IP_uc001svn.2_Missense_Mutation_p.E32K|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.E48K|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	48					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGAACTCAAGAGCAGACTAC	0.458			NA											11	244					0	0	0.010729	0	0
RAB3IP	117177	broad.mit.edu	37	12	70150234	70150234	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:70150234G>A	uc001svp.2	+	3	796	c.349G>A	c.(349-351)GGA>AGA	p.G117R	RAB3IP_uc001svl.1_Missense_Mutation_p.G101R|RAB3IP_uc001svm.2_Missense_Mutation_p.G101R|RAB3IP_uc001svn.2_Missense_Mutation_p.G101R|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.G117R|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	117					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			AGTCACAGCTGGATTAACTAA	0.408			NA											17	284					0	0	0.004007	0	0
ERP29	10961	broad.mit.edu	37	12	112460060	112460060	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr12:112460060C>T	uc001ttk.1	+	3	508	c.390C>T	c.(388-390)GTC>GTT	p.V130V	ERP29_uc001ttl.1_3'UTR	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	130					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0						AGAACCCAGTCCCATACACTG	0.552			NA											4	34					0	0	0.009096	0	0
BRCA2	675	broad.mit.edu	37	13	32914937	32914937	+	Missense_Mutation	SNP	A	A	G	rs80359592		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr13:32914937A>G	uc001uub.1	+	11	6672	c.6445A>G	c.(6445-6447)ATT>GTT	p.I2149V		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2149					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TAATCACTCTATTAAAGTTTC	0.318	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			4	24					0	0	0.001168	0	0
LHFP	10186	broad.mit.edu	37	13	40175151	40175151	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr13:40175151C>T	uc001uxf.2	-	2	714	c.203G>A	c.(202-204)TGT>TAT	p.C68Y		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	68						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		ATAGCGCCCACATTCCTCCAC	0.602			NA	T	HMGA2	lipoma								45	160					0	0	0.01441	0	0
DGKH	160851	broad.mit.edu	37	13	42795487	42795487	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr13:42795487T>C	uc001uyl.1	+	29	3551	c.3530T>C	c.(3529-3531)ATC>ACC	p.I1177T	DGKH_uc010tfh.1_Intron|DGKH_uc001uym.1_Intron|DGKH_uc010tfi.1_Intron|DGKH_uc010tfj.1_Missense_Mutation_p.I1032T|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.I1032T|DGKH_uc001uyp.2_Intron	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	1177	SAM.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CGTCATGACATCAGAGGGGCT	0.413			NA											13	115					0	0	0.00245	0	0
FAM155A	728215	broad.mit.edu	37	13	107862936	107862936	+	Silent	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr13:107862936A>G	uc001vql.2	-	2	1599	c.1083T>C	c.(1081-1083)TGT>TGC	p.C361C		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	361						integral to membrane	binding			skin(1)	1						CTGTACCTGTACAGATGAAAC	0.458			NA											7	48					0	0	0.004482	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216160	20216160	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:20216160G>T	uc010tkt.1	+	1	574	c.574G>T	c.(574-576)GAC>TAC	p.D192Y		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCCTGCATGGACACCTATGT	0.488			NA											8	102					3.09899e-07	3.82816e-07	0.004482	1	0
AKAP6	9472	broad.mit.edu	37	14	33016066	33016066	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:33016066A>T	uc001wrq.2	+	4	2377	c.2207A>T	c.(2206-2208)TAT>TTT	p.Y736F	AKAP6_uc010aml.2_Missense_Mutation_p.Y733F	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	736					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATGAAAAAGTATGCTGATGAG	0.443	Melanoma(49;821 1200 7288 13647 42351)		NA											9	89					0	0	0.004482	0	0
MIA2	117153	broad.mit.edu	37	14	39721990	39721990	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:39721990G>A	uc001wux.2	+	5	1800	c.1606G>A	c.(1606-1608)GAA>AAA	p.E536K		NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	145						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GAGAATTCACGAAGAAGTATA	0.378			NA											10	141					0	0	0.001855	0	0
FSCB	84075	broad.mit.edu	37	14	44975456	44975456	+	Missense_Mutation	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:44975456T>G	uc001wvn.2	-	1	1044	c.735A>C	c.(733-735)GAA>GAC	p.E245D		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	245						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CAGCAGAACCTTCTTGTACAA	0.413			NA											10	148					0	0	0.006214	0	0
KLHL28	54813	broad.mit.edu	37	14	45414803	45414803	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45414803G>A	uc001wvq.2	-	2	575	c.329C>T	c.(328-330)CCA>CTA	p.P110L	KLHL28_uc001wvr.2_Missense_Mutation_p.P110L|KLHL28_uc001wvt.3_Missense_Mutation_p.P110L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	110										ovary(1)	1						GTTTGCTGCTGGCAGGAGAGA	0.408			NA											4	140					0	0	0.008871	0	0
KLHL28	54813	broad.mit.edu	37	14	45414807	45414807	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45414807G>A	uc001wvq.2	-	2	571	c.325C>T	c.(325-327)CTG>TTG	p.L109L	KLHL28_uc001wvr.2_Silent_p.L109L|KLHL28_uc001wvt.3_Silent_p.L109L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	109										ovary(1)	1						GCTGCTGGCAGGAGAGATTCA	0.418			NA											5	145					0	0	0.012319	0	0
KLHL28	54813	broad.mit.edu	37	14	45414812	45414812	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45414812G>A	uc001wvq.2	-	2	566	c.320C>T	c.(319-321)TCT>TTT	p.S107F	KLHL28_uc001wvr.2_Missense_Mutation_p.S107F|KLHL28_uc001wvt.3_Missense_Mutation_p.S107F	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	107										ovary(1)	1						TGGCAGGAGAGATTCAACTGT	0.413			NA											5	147					0	0	0.014323	0	0
KLHL28	54813	broad.mit.edu	37	14	45415021	45415021	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45415021G>A	uc001wvq.2	-	2	357	c.111C>T	c.(109-111)ATC>ATT	p.I37I	KLHL28_uc001wvr.2_Silent_p.I37I|KLHL28_uc001wvt.3_Silent_p.I37I	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	37	BTB.									ovary(1)	1						CTCGAAGAATGATGTCACAGA	0.443			NA											18	120					0	0	0.007413	0	0
KLHL28	54813	broad.mit.edu	37	14	45415118	45415118	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45415118G>A	uc001wvq.2	-	2	260	c.14C>T	c.(13-15)TCC>TTC	p.S5F	KLHL28_uc001wvr.2_Missense_Mutation_p.S5F|KLHL28_uc001wvt.3_Missense_Mutation_p.S5F	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	5										ovary(1)	1						GTAGGTCGGGGATGTGTGGTC	0.378			NA											19	91					0	0	0.006122	0	0
KLHL28	54813	broad.mit.edu	37	14	45415125	45415125	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45415125G>A	uc001wvq.2	-	2	253	c.7C>T	c.(7-9)CAC>TAC	p.H3Y	KLHL28_uc001wvr.2_Missense_Mutation_p.H3Y|KLHL28_uc001wvt.3_Missense_Mutation_p.H3Y	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	3										ovary(1)	1						GGGGATGTGTGGTCCATCTAC	0.373			NA											19	87					0	0	0.007413	0	0
FANCM	57697	broad.mit.edu	37	14	45633573	45633573	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:45633573G>T	uc001wwd.3	+	10	1692	c.1593G>T	c.(1591-1593)CAG>CAT	p.Q531H	FANCM_uc001wwc.2_Missense_Mutation_p.Q531H|FANCM_uc010anf.2_Missense_Mutation_p.Q505H|FANCM_uc001wwe.3_Intron	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	531	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TAGTGAAACAGTTTCGTGACG	0.353			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				23	68					2.44723e-14	3.44142e-14	0.004656	1	0
PPIL5	122769	broad.mit.edu	37	14	50081137	50081137	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:50081137G>T	uc001wwn.2	+	4	1492	c.1168G>T	c.(1168-1170)GGT>TGT	p.G390C	SDCCAG1_uc010anj.1_Intron|PPIL5_uc001wwo.2_3'UTR|PPIL5_uc010ank.2_Missense_Mutation_p.G331C|PPIL5_uc001wwp.2_RNA	NM_152329	NP_689542	Q96L50	LLR1_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 5	390											0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AGATAATTTGGGTGGTACTGA	0.373			NA											3	72					0.004672	0.00507476	0.004672	1	0
BMP4	652	broad.mit.edu	37	14	54417079	54417079	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:54417079G>A	uc001xal.3	-	3	1085	c.898C>T	c.(898-900)CGG>TGG	p.R300W	BMP4_uc010aoh.2_Missense_Mutation_p.R300W|BMP4_uc001xao.3_Missense_Mutation_p.R300W|BMP4_uc001xan.3_Missense_Mutation_p.R300W	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	300					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						TTCCTGGCCCGCTGTGAGTGA	0.627			NA											3	44					0	0	0.004672	0	0
DAAM1	23002	broad.mit.edu	37	14	59835440	59835440	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:59835440G>T	uc001xdz.1	+	26	3225	c.3100G>T	c.(3100-3102)GAT>TAT	p.D1034Y	DAAM1_uc001xea.1_Missense_Mutation_p.D1024Y|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	1034	DAD.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CGGAGAGTTTGATGACCTTGT	0.388			NA											4	67					0.00909568	0.00974537	0.009096	1	0
ALDH6A1	4329	broad.mit.edu	37	14	74533589	74533589	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr14:74533589C>T	uc001xpo.2	-	9	1142	c.1043G>A	c.(1042-1044)GGA>GAA	p.G348E	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_Missense_Mutation_p.G193E|ALDH6A1_uc010tuq.1_Missense_Mutation_p.G335E	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	348						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	AGGCTGATCTCCTGTAAAACA	0.368			NA											10	23					0	0	0.008291	0	0
GABRB3	2562	broad.mit.edu	37	15	26825499	26825499	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:26825499G>T	uc001zaz.2	-	6	791	c.649C>A	c.(649-651)CGT>AGT	p.R217S	GABRB3_uc010uae.1_Missense_Mutation_p.R132S|GABRB3_uc001zba.2_Missense_Mutation_p.R217S|GABRB3_uc001zbb.2_Missense_Mutation_p.R273S	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	217	Extracellular (Probable).		R -> H (in insomnia; functional analysis reveals a slower rate of the fast phase of desensitization compared with alpha1beta3gamma2S GABA(A) receptors; current deactivation is faster in the mutated receptors).		synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAGACCAGACGGTGCTCCACG	0.562			NA											15	85					5.03518e-11	6.89601e-11	0.007413	1	0
GABRB3	2562	broad.mit.edu	37	15	26825521	26825521	+	Silent	SNP	C	C	A	rs146431931		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:26825521C>A	uc001zaz.2	-	6	769	c.627G>T	c.(625-627)CCG>CCT	p.P209P	GABRB3_uc010uae.1_Silent_p.P124P|GABRB3_uc001zba.2_Silent_p.P209P|GABRB3_uc001zbb.2_Silent_p.P265P	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	209	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGGAGAACTGCGGGAGCTCAA	0.562			NA											15	82					0.000219431	0.000249534	0.00245	1	0
GABRB3	2562	broad.mit.edu	37	15	26866463	26866463	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:26866463G>A	uc001zaz.2	-	4	601	c.459C>T	c.(457-459)CTC>CTT	p.L153L	GABRB3_uc010uae.1_Silent_p.L68L|GABRB3_uc001zba.2_Silent_p.L153L|GABRB3_uc001zbb.2_Silent_p.L209L|GABRB3_uc001zbc.2_RNA	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	153	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACACAGACCTGAGCCCATACA	0.438			NA											13	64					0	0	0.00245	0	0
FMN1	342184	broad.mit.edu	37	15	33359339	33359339	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:33359339C>A	uc001zhf.3	-	1	747	c.747G>T	c.(745-747)CAG>CAT	p.Q249H	FMN1_uc001zhg.2_Missense_Mutation_p.Q249H	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CACTCGAATTCTGGTTTGTTA	0.512			NA											11	89					2.27111e-07	2.81653e-07	0.013537	1	0
RPAP1	26015	broad.mit.edu	37	15	41829206	41829206	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:41829206C>A	uc001zod.2	-	2	242	c.118G>T	c.(118-120)GGT>TGT	p.G40C		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	40						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCATCACCACCGCCCCTATTT	0.587			NA											11	127					7.03913e-09	9.12479e-09	0.013537	1	0
C15orf42	90381	broad.mit.edu	37	15	90168095	90168095	+	Silent	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:90168095T>A	uc002boe.2	+	20	4554	c.4554T>A	c.(4552-4554)CCT>CCA	p.P1518P	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1518					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGGCTCTCCTCTGATGCCTT	0.577			NA											57	54					0	0	0.01441	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100649223	100649223	+	Missense_Mutation	SNP	T	T	C	rs76569625		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr15:100649223T>C	uc002bvv.1	-	14	2066	c.1987A>G	c.(1987-1989)ACT>GCT	p.T663A	ADAMTS17_uc002bvx.1_Missense_Mutation_p.T420A	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	663	Cys-rich.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CAGAGATCAGTCTCGTAGGGC	0.617			NA											25	65					0	0	0.00632	0	0
ERCC4	2072	broad.mit.edu	37	16	14015970	14015970	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr16:14015970G>T	uc002dce.2	+	2	299	c.290G>T	c.(289-291)CGC>CTC	p.R97L	ERCC4_uc010bva.2_Missense_Mutation_p.R97L	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	97					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						AGCAACAGTCGCTATGAAGTT	0.373			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	39					2.0095e-06	2.43458e-06	0.001984	1	0
Unknown	0	broad.mit.edu	37	16	90161578	90161578	+	Silent	SNP	G	G	A	rs13337896	by1000genomes	TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr16:90161578G>A	uc002fqp.2	+	3	931	c.453G>A	c.(451-453)ACG>ACA	p.T151T	uc002fqq.2_Silent_p.T168T					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.												NA						GCCAAGGGACGCTACACCGAA	0.587			NA											3	54					0	0	0.004672	0	0
CLDN7	1366	broad.mit.edu	37	17	7163726	7163726	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:7163726G>A	uc002gfm.3	-	4	1036	c.603C>T	c.(601-603)TAC>TAT	p.Y201Y	CLDN7_uc010cmc.2_3'UTR|CLDN7_uc002gfn.3_Silent_p.Y201Y	NM_001307	NP_001298	O95471	CLD7_HUMAN	claudin 7	201	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						TGGACTTAGGGTAAGAGCGGG	0.592			NA											11	84					0	0	0.001855	0	0
Unknown	0	broad.mit.edu	37	17	21731278	21731278	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:21731278G>T	uc002gyy.3	+	2	705	c.580G>T	c.(580-582)GGC>TGC	p.G194C						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GATCAGCAGAGGCTCATCTTT	0.547			NA											8	65					1.12685e-05	1.33443e-05	0.004482	1	0
PIGW	284098	broad.mit.edu	37	17	34894132	34894132	+	Silent	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:34894132T>A	uc002hmy.1	+	2	1225	c.1182T>A	c.(1180-1182)ATT>ATA	p.I394I	MYO19_uc010wcy.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.I394I	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	394					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTGATATAATTTTGAGTTTTG	0.343			NA											10	54					0	0	0.008291	0	0
KRT40	125115	broad.mit.edu	37	17	39135199	39135199	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:39135199G>A	uc010cxh.1	-	8	1214	c.1053C>T	c.(1051-1053)ATC>ATT	p.I351I	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	351	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				CCAGGTTATCGATCAGACACT	0.547			NA											4	152					0	0	0.001168	0	0
DNAJC7	7266	broad.mit.edu	37	17	40139846	40139846	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:40139846C>A	uc002hyo.2	-	9	1238	c.1001G>T	c.(1000-1002)AGA>ATA	p.R334I	DNAJC7_uc010cxu.2_Missense_Mutation_p.R278I|DNAJC7_uc010cxv.2_Missense_Mutation_p.R278I|DNAJC7_uc010wgb.1_Missense_Mutation_p.R278I|DNAJC7_uc010wgc.1_Missense_Mutation_p.R192I|DNAJC7_uc002hyp.2_Missense_Mutation_p.R278I|DNAJC7_uc010cxw.2_RNA	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	334	TPR 9.				chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				CCACTGAGCTCTTCTCAAGTA	0.478	Colon(63;618 1117 8600 10857 19751)		NA											3	14					0.00909568	0.00974537	0.009096	1	0
SLC16A5	9121	broad.mit.edu	37	17	73102069	73102069	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:73102069T>C	uc002jmr.2	+	7	1831	c.1459T>C	c.(1459-1461)TGG>CGG	p.W487R	SLC16A5_uc002jmt.2_Missense_Mutation_p.W487R|SLC16A5_uc002jmu.2_Missense_Mutation_p.W487R	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	487	Cytoplasmic (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GTGGCTCTTATGGCCAAAGGC	0.383			NA									OREG0024726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	20					0	0	0.004672	0	0
CBX2	84733	broad.mit.edu	37	17	77758731	77758731	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr17:77758731C>A	uc002jxc.2	+	5	1531	c.1489C>A	c.(1489-1491)CGC>AGC	p.R497S		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	497					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GAAGCCCACCCGCAGCCTCAT	0.622			NA											9	36					0.000274275	0.000305289	0.004482	1	0
ADCYAP1	116	broad.mit.edu	37	18	905469	905469	+	Missense_Mutation	SNP	G	G	T	rs8192594		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr18:905469G>T	uc010dkg.2	+	2	201	c.82G>T	c.(82-84)GCC>TCC	p.A28S	ADCYAP1_uc010dkh.2_Missense_Mutation_p.A28S	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	28					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						CTCACCTGCCGCCGCCGGACT	0.632			NA											13	89					2.27111e-07	2.81653e-07	0.013537	1	0
ASXL3	80816	broad.mit.edu	37	18	31323630	31323630	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr18:31323630C>T	uc010dmg.1	+	12	3873	c.3818C>T	c.(3817-3819)ACA>ATA	p.T1273I	ASXL3_uc002kxq.2_Missense_Mutation_p.T980I	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1273	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCAAACACTACAATTTCTGCT	0.388			NA											7	46					0	0	0.00308	0	0
FHOD3	80206	broad.mit.edu	37	18	34298333	34298333	+	Silent	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr18:34298333A>C	uc002kzt.1	+	15	2593	c.2496A>C	c.(2494-2496)CCA>CCC	p.P832P	FHOD3_uc002kzs.1_Silent_p.P849P|FHOD3_uc010dmz.1_Silent_p.P564P|FHOD3_uc010dna.1_Silent_p.P152P	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	832	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACCTCCCCCACCCCCACCCA	0.607			NA											3	22					0	0	0.001855	0	0
C18orf54	162681	broad.mit.edu	37	18	51887198	51887198	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr18:51887198T>A	uc002lfn.3	+	2	372	c.256T>A	c.(256-258)TGC>AGC	p.C86S	C18orf54_uc002lfo.3_Missense_Mutation_p.C86S	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	86						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		GTCACAGTTCTGCAACTATAT	0.323			NA											11	100					0	0	0.010729	0	0
CDH7	1005	broad.mit.edu	37	18	63526255	63526255	+	Silent	SNP	C	C	T	rs147764044		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr18:63526255C>T	uc002ljz.2	+	9	1792	c.1467C>T	c.(1465-1467)ACC>ACT	p.T489T	CDH7_uc002lka.2_Silent_p.T489T|CDH7_uc002lkb.2_Silent_p.T489T	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	489	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATGAGACCACCGTCTGTGAAA	0.433			NA											8	65					0	0	0.006214	0	0
ITGB1BP3	27231	broad.mit.edu	37	19	3942134	3942134	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:3942134G>A	uc002lyz.3	+	8	846	c.556G>A	c.(556-558)GAC>AAC	p.D186N	ITGB1BP3_uc010xia.1_Missense_Mutation_p.D191N	NM_170678	NP_733778	Q9NPI5	NRK2_HUMAN	integrin beta 1 binding protein 3	186					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|protein binding|ribosylnicotinamide kinase activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCTGGAAGACATTCAGAA	0.637			NA											4	58					0	0	0.009096	0	0
C3	718	broad.mit.edu	37	19	6680180	6680180	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:6680180T>C	uc002mfm.2	-	36	4507	c.4445A>G	c.(4444-4446)TAT>TGT	p.Y1482C	C3_uc002mfl.2_Missense_Mutation_p.Y218C	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1482					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAGGTTGTAATAGGCGTAGAC	0.498			NA											8	61					0	0	0.004482	0	0
ZNF317	57693	broad.mit.edu	37	19	9271460	9271460	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:9271460A>G	uc002mku.2	+	7	1414	c.1139A>G	c.(1138-1140)CAC>CGC	p.H380R	ZNF317_uc002mkv.2_Missense_Mutation_p.H239R|ZNF317_uc002mkw.2_Missense_Mutation_p.H348R|ZNF317_uc002mkx.2_Missense_Mutation_p.H295R|ZNF317_uc002mky.2_Missense_Mutation_p.H263R	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	380	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTAATTTGCACAAGAAGAAC	0.522			NA											8	11					0	0	0.00308	0	0
ELAVL3	1995	broad.mit.edu	37	19	11565613	11565613	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:11565613C>A	uc002mry.1	-	7	1212	c.832G>T	c.(832-834)GGC>TGC	p.G278C	ELAVL3_uc002mrx.1_Missense_Mutation_p.G271C	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	278					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3						cccgccgcgccccccgACAGG	0.567			NA											39	43					9.85521e-28	1.45065e-27	0.00623	1	0
ZNF563	147837	broad.mit.edu	37	19	12429554	12429554	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:12429554C>T	uc002mtp.2	-	4	1523	c.1285G>A	c.(1285-1287)GCG>ACG	p.A429T		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	429	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGATAACGCTTTCCCACAC	0.428	GBM(39;623 795 5132 29510 31476)		NA											4	149					0	0	0.009096	0	0
SYCE2	256126	broad.mit.edu	37	19	13015425	13015425	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:13015425G>A	uc002mvr.2	-	3	202	c.187C>T	c.(187-189)CTG>TTG	p.L63L		NM_001105578	NP_001099048	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	63	Potential.				cell division	central element					0						CTTGAGTCCAGAGAGGAGAAG	0.532			NA											6	133					0	0	0.00308	0	0
C19orf42	79086	broad.mit.edu	37	19	16764904	16764904	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:16764904T>C	uc002ner.2	-	4	201	c.154A>G	c.(154-156)AGA>GGA	p.R52G	C19orf42_uc002neo.1_RNA|C19orf42_uc002nep.1_Intron	NM_024104	NP_077009	Q9BQ49	CS042_HUMAN	hypothetical protein LOC79086 precursor	52	Extracellular (Potential).					integral to membrane					0						CGAAAGTATCTGAGGCTCAGC	0.483			NA											3	47					0	0	0.009096	0	0
TMEM59L	25789	broad.mit.edu	37	19	18731311	18731311	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:18731311C>A	uc002njy.3	+	8	1081	c.994C>A	c.(994-996)CCC>ACC	p.P332T		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	332						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CAGCCTACCACCCTACAAGCT	0.657			NA											14	56					2.31682e-05	2.71301e-05	0.003163	1	0
ZNF208	7757	broad.mit.edu	37	19	22155891	22155891	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:22155891C>A	uc002nqp.2	-	5	1794	c.1645G>T	c.(1645-1647)GTC>TTC	p.V549F	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGGGTTGAGACCTTAATAAAG	0.388			NA											27	71					5.61819e-17	8.04422e-17	0.005443	1	0
ZNF829	374899	broad.mit.edu	37	19	37406057	37406057	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:37406057G>A	uc002ofa.1	-	2	375	c.13C>T	c.(13-15)CCT>TCT	p.P5S	ZNF568_uc010efg.2_5'Flank|ZNF568_uc010xtn.1_5'Flank|ZNF829_uc002ofb.2_Missense_Mutation_p.P5S|ZNF568_uc002ofc.2_5'Flank|ZNF568_uc002ofd.2_5'Flank|ZNF568_uc010efe.2_5'Flank|ZNF568_uc010eff.1_5'Flank	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGATCAGAGGAGAATGGGGC	0.498			NA											6	41					0	0	0.001984	0	0
ZNF578	147660	broad.mit.edu	37	19	53014565	53014565	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:53014565G>A	uc002pzp.3	+	6	1175	c.931G>A	c.(931-933)GGT>AGT	p.G311S		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATGTCACACTGGTGAGAAACC	0.418			NA											5	83					0	0	0.000602	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55341578	55341578	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:55341578G>T	uc002qhk.3	+	9	1246	c.1183G>T	c.(1183-1185)GAG>TAG	p.E395*	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Nonsense_Mutation_p.E320*|KIR3DL1_uc010esf.2_Nonsense_Mutation_p.E300*|KIR3DL1_uc010yfo.1_Nonsense_Mutation_p.E337*|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	395	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AGACCCTGAGGAGGTGACATA	0.512			NA											42	254					8.72198e-27	1.27787e-26	0.01441	1	0
NLRP2	55655	broad.mit.edu	37	19	55493791	55493791	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr19:55493791C>A	uc002qij.2	+	6	811	c.725C>A	c.(724-726)GCG>GAG	p.A242E	NLRP2_uc010yfp.1_Missense_Mutation_p.A219E|NLRP2_uc010esn.2_Missense_Mutation_p.A218E|NLRP2_uc010eso.2_Missense_Mutation_p.A239E|NLRP2_uc010esp.2_Missense_Mutation_p.A220E	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	242	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TTCAAATATGCGTTCTACCTC	0.552			NA											13	9					0.000151284	0.000174559	0.001855	1	0
XDH	7498	broad.mit.edu	37	2	31571173	31571173	+	Silent	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:31571173C>A	uc002rnv.1	-	28	3187	c.3108G>T	c.(3106-3108)GGG>GGT	p.G1036G		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1036					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCATCTCAGTCCCCCCGTGGG	0.483	Colon(66;682 1445 30109 40147)		NA											19	47					0.000229342	0.000259866	0.012319	1	0
VIT	5212	broad.mit.edu	37	2	37035904	37035904	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:37035904T>C	uc002rpl.2	+	15	1900	c.1679T>C	c.(1678-1680)CTG>CCG	p.L560P	VIT_uc002rpm.2_Missense_Mutation_p.L538P|VIT_uc010ezv.2_Missense_Mutation_p.L516P|VIT_uc010ezw.2_Missense_Mutation_p.L517P	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	545	VWFA 2.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GAACAGCGGCTGGAGTTTGGG	0.592			NA											3	83					0	0	0.009096	0	0
PNPT1	87178	broad.mit.edu	37	2	55874559	55874559	+	Missense_Mutation	SNP	C	C	G	rs146571352	byFrequency	TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:55874559C>G	uc002rzf.2	-	19	1578	c.1525G>C	c.(1525-1527)GTA>CTA	p.V509L	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	509					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CCTATTGCTACGCCTGCAACA	0.373			NA											13	83					0	0	0.003163	0	0
NAGK	55577	broad.mit.edu	37	2	71299832	71299832	+	Silent	SNP	C	C	T	rs150661812		TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:71299832C>T	uc002shp.3	+	5	823	c.417C>T	c.(415-417)TCC>TCT	p.S139S	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_5'UTR|NAGK_uc002shr.2_Silent_p.S88S	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	139					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	CTGATGGCTCCGAGAGTGGCT	0.602			NA											4	51					0	0	0.009096	0	0
ALMS1	7840	broad.mit.edu	37	2	73635838	73635838	+	Missense_Mutation	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:73635838T>G	uc002sje.1	+	3	527	c.416T>G	c.(415-417)TTG>TGG	p.L139W	ALMS1_uc002sjf.1_Intron	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	138					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GTGGTCTGTTTGGAAACAACA	0.368			NA											3	156					0	0	0.009096	0	0
REG3A	5068	broad.mit.edu	37	2	79385459	79385459	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:79385459G>C	uc002sod.1	-	3	581	c.326C>G	c.(325-327)CCC>CGC	p.P109R	REG3A_uc002soe.1_Missense_Mutation_p.P109R|REG3A_uc002sof.1_Missense_Mutation_p.P109R	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	109	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						CACCTGTGTGGGGTCATGGAG	0.567			NA											5	65					0	0	0.001168	0	0
THSD7B	80731	broad.mit.edu	37	2	137814712	137814712	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:137814712C>G	uc002tva.1	+	2	769	c.769C>G	c.(769-771)CAT>GAT	p.H257D	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.H147D	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAAAGCACATCATCATTCGAA	0.383			NA											7	45					0	0	0.00308	0	0
RIF1	55183	broad.mit.edu	37	2	152319779	152319779	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:152319779G>C	uc002txm.2	+	30	3875	c.3745G>C	c.(3745-3747)GTG>CTG	p.V1249L	RIF1_uc002txl.2_Missense_Mutation_p.V1249L|RIF1_uc002txn.2_Missense_Mutation_p.V1249L|RIF1_uc002txo.2_Missense_Mutation_p.V1249L|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1249					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AACTGTTACAGTGAAAAATAA	0.333			NA											10	75					0	0	0.008291	0	0
ITGB6	3694	broad.mit.edu	37	2	161025799	161025799	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:161025799T>C	uc002ubh.2	-	7	957	c.941A>G	c.(940-942)CAA>CGA	p.Q314R	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Missense_Mutation_p.Q314R|ITGB6_uc010zcq.1_Missense_Mutation_p.Q272R|ITGB6_uc010fov.1_Missense_Mutation_p.Q314R	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	314	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						ATCAATGAGTTGTCCAATTGT	0.274			NA											15	95					0	0	0.007413	0	0
SCN1A	6323	broad.mit.edu	37	2	166892607	166892607	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:166892607A>G	uc010zcz.1	-	16	3365	c.3347T>C	c.(3346-3348)TTA>TCA	p.L1116S	SCN1A_uc002udo.3_Missense_Mutation_p.L996S|SCN1A_uc010fpk.2_Missense_Mutation_p.L968S	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1127						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTCCGTGTTTAAATTTTCAAA	0.323			NA											8	169					0	0	0.006214	0	0
ATF2	1386	broad.mit.edu	37	2	175939413	175939413	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:175939413G>A	uc002ujl.2	-	14	1704	c.1442C>T	c.(1441-1443)GCG>GTG	p.A481V	ATF2_uc010fqv.2_Missense_Mutation_p.A432V|ATF2_uc002ujv.2_Missense_Mutation_p.A228V|ATF2_uc002ujm.2_Missense_Mutation_p.A423V|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Missense_Mutation_p.A120V|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Missense_Mutation_p.A481V|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Missense_Mutation_p.A463V|ATF2_uc002ujs.2_Missense_Mutation_p.A423V|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_3'UTR|ATF2_uc002ujx.1_RNA|uc002ujk.2_5'Flank	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	481					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			ACTCTGGTCCGCCATCTGGGT	0.498	Pancreas(17;87 705 4534 15538 30988)		NA											3	42					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179395519	179395519	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179395519C>T	uc010zfg.1	-	307	98343	c.98119G>A	c.(98119-98121)GAG>AAG	p.E32707K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E26402K|TTN_uc010zfi.1_Missense_Mutation_p.E26335K|TTN_uc010zfj.1_Missense_Mutation_p.E26210K|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33634							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAACTTTCTCTGTTGGTGTT	0.468			NA											4	44					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179403902	179403902	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179403902C>T	uc010zfg.1	-	302	91280	c.91056G>A	c.(91054-91056)CGG>CGA	p.R30352R	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R24047R|TTN_uc010zfi.1_Silent_p.R23980R|TTN_uc010zfj.1_Silent_p.R23855R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31279							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTTGGGCCGGGACCAGG	0.473			NA											7	52					0	0	0.00308	0	0
TTN	7273	broad.mit.edu	37	2	179439116	179439116	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179439116G>T	uc010zfg.1	-	275	64263	c.64039C>A	c.(64039-64041)CCA>ACA	p.P21347T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P15042T|TTN_uc010zfi.1_Missense_Mutation_p.P14975T|TTN_uc010zfj.1_Missense_Mutation_p.P14850T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22274							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTCTGATGGCTTGCTTGGC	0.438			NA											10	178					1.33987e-11	1.85114e-11	0.008291	1	0
TTN	7273	broad.mit.edu	37	2	179474087	179474087	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179474087G>T	uc010zfg.1	-	222	44470	c.44246C>A	c.(44245-44247)CCT>CAT	p.P14749H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P8444H|TTN_uc010zfi.1_Missense_Mutation_p.P8377H|TTN_uc010zfj.1_Missense_Mutation_p.P8252H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15676							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGTCAGAGGCAGGACAAA	0.448			NA											8	42					9.70103e-10	1.28938e-09	0.008291	1	0
TTN	7273	broad.mit.edu	37	2	179554545	179554545	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179554545G>T	uc010zfg.1	-	119	28333	c.28109C>A	c.(28108-28110)GCT>GAT	p.A9370D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A6031D|TTN_uc010fre.1_Missense_Mutation_p.A481D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10297							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTACCTTTAGCTGGGGGAGC	0.368			NA											16	142					6.94344e-10	9.34694e-10	0.006122	1	0
TTN	7273	broad.mit.edu	37	2	179599266	179599266	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:179599266C>A	uc010zfg.1	-	49	11777	c.11553G>T	c.(11551-11553)CAG>CAT	p.Q3851H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q512H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4778							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGACTTCACACTGAAGTAGAG	0.378			NA											14	75					3.27435e-08	4.12568e-08	0.00245	1	0
COL5A2	1290	broad.mit.edu	37	2	189918906	189918906	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:189918906C>T	uc002uqk.2	-	36	2699	c.2424G>A	c.(2422-2424)CCG>CCA	p.P808P	COL5A2_uc010frx.2_Silent_p.P384P	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	808					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TAGGACCTGCCGGACCTGGAG	0.398			NA											4	99					0	0	0.009096	0	0
ERBB4	2066	broad.mit.edu	37	2	212989572	212989572	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:212989572G>C	uc002veg.1	-	2	237	c.139C>G	c.(139-141)CGA>GGA	p.R47G	ERBB4_uc002veh.1_Missense_Mutation_p.R47G|ERBB4_uc010zji.1_Missense_Mutation_p.R47G|ERBB4_uc010zjj.1_Missense_Mutation_p.R47G|ERBB4_uc010fut.1_Missense_Mutation_p.R47G	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	47	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGCAAGGCTCGGTACTGCTGT	0.473			NA								TSP Lung(8;0.080)			5	49					0	0	0.000602	0	0
DNAJB2	3300	broad.mit.edu	37	2	220146664	220146664	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:220146664C>T	uc002vkx.1	+	5	470	c.233C>T	c.(232-234)ACT>ATT	p.T78I	DNAJB2_uc010zla.1_Missense_Mutation_p.T78I|DNAJB2_uc002vkw.1_Missense_Mutation_p.T78I|DNAJB2_uc002vky.2_5'Flank|DNAJB2_uc010zlb.1_5'Flank	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	78					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTCCAGGAACTGGCCCATCT	0.622			NA											4	46					0	0	0.009096	0	0
PTPRN	5798	broad.mit.edu	37	2	220167119	220167119	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:220167119C>T	uc002vkz.2	-	6	823	c.734G>A	c.(733-735)AGC>AAC	p.S245N	PTPRN_uc010zlc.1_Missense_Mutation_p.S155N|PTPRN_uc002vla.2_Missense_Mutation_p.S245N	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	245	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GGCAGTTCTGCTGAAGAGGGC	0.632			NA											6	20					0	0	0.001984	0	0
SPEG	10290	broad.mit.edu	37	2	220313108	220313108	+	Nonsense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:220313108C>T	uc010fwg.2	+	4	1228	c.1228C>T	c.(1228-1230)CGA>TGA	p.R410*	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR|SPEG_uc002vlp.1_5'Flank	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	410					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTTCGAGGAGCGACGGCGCAG	0.736			NA											2	2					0	0	0.004672	0	0
GIGYF2	26058	broad.mit.edu	37	2	233651927	233651927	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:233651927A>T	uc002vti.3	+	11	937	c.600A>T	c.(598-600)GAA>GAT	p.E200D	GIGYF2_uc010zmj.1_Missense_Mutation_p.E200D|GIGYF2_uc002vtg.2_Missense_Mutation_p.E200D|GIGYF2_uc002vtj.3_Missense_Mutation_p.E222D|GIGYF2_uc002vtk.3_Missense_Mutation_p.E200D|GIGYF2_uc002vth.3_Missense_Mutation_p.E200D|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.E31D	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	200	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TACGCTCAGAAAGTGAAAATT	0.423			NA											25	50					0	0	0.009535	0	0
CXCR7	57007	broad.mit.edu	37	2	237489437	237489437	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:237489437G>C	uc010fyq.2	+	3	559	c.329G>C	c.(328-330)TGG>TCG	p.W110S	CXCR7_uc002vwd.2_Missense_Mutation_p.W110S	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	110	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		CACAACCAGTGGCCCATGGGC	0.562			NA											11	124					0	0	0.013537	0	0
ANO7	50636	broad.mit.edu	37	2	242138778	242138778	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:242138778C>A	uc002wax.2	+	5	622	c.519C>A	c.(517-519)AGC>AGA	p.S173R		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	173	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCCTCCTCAGCGCCTCCTGGG	0.652			NA											7	70					5.18039e-06	6.18115e-06	0.00308	1	0
D2HGDH	728294	broad.mit.edu	37	2	242690764	242690764	+	Silent	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr2:242690764G>C	uc002wce.1	+	8	1274	c.1101G>C	c.(1099-1101)GTG>GTC	p.V367V	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Silent_p.V233V|D2HGDH_uc002wcg.1_Intron|D2HGDH_uc002wch.2_Intron|D2HGDH_uc002wci.2_Silent_p.V66V	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	367					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CCGGCCTGGTGACCGATGGGA	0.627			NA											7	36					0	0	0.004482	0	0
PLCB1	23236	broad.mit.edu	37	20	8745793	8745793	+	Missense_Mutation	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:8745793A>C	uc002wnb.2	+	26	2721	c.2718A>C	c.(2716-2718)GAA>GAC	p.E906D	PLCB1_uc010zrb.1_Missense_Mutation_p.E805D|PLCB1_uc002wna.2_Missense_Mutation_p.E906D|PLCB1_uc002wnc.1_Missense_Mutation_p.E805D|PLCB1_uc002wnd.1_Missense_Mutation_p.E483D	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	906					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CAGAAGTGGAAGCACAGACCA	0.408			NA											7	28					0	0	0.004482	0	0
SNAP25	6616	broad.mit.edu	37	20	10273857	10273857	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:10273857T>A	uc002wnq.1	+	5	424	c.212T>A	c.(211-213)ATG>AAG	p.M71K	SNAP25_uc002wnr.1_Intron|SNAP25_uc002wns.1_Missense_Mutation_p.M8K|SNAP25_uc010gca.1_Intron|SNAP25_uc010gcb.1_Missense_Mutation_p.M8K|SNAP25_uc010gcc.1_Intron	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	71	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	AATAAGGACATGAAAGAAGCA	0.438			NA											19	74					0	0	0.012319	0	0
HCK	3055	broad.mit.edu	37	20	30689307	30689307	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:30689307C>A	uc002wxh.2	+	13	1737	c.1566C>A	c.(1564-1566)TAC>TAA	p.Y522*	HCK_uc010gdy.2_Nonsense_Mutation_p.Y501*|HCK_uc002wxi.2_Nonsense_Mutation_p.Y500*	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	522					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAGCCAGTACCAACAGCAGC	0.632			NA											3	23					0.004672	0.00507476	0.004672	1	0
CTSA	5476	broad.mit.edu	37	20	44527020	44527020	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:44527020G>T	uc002xqj.3	+	15	1848	c.1374G>T	c.(1372-1374)ATG>ATT	p.M458I	CTSA_uc002xqh.2_Missense_Mutation_p.M476I|CTSA_uc002xqi.2_RNA|CTSA_uc010zxi.1_Missense_Mutation_p.M459I|CTSA_uc002xqk.3_Missense_Mutation_p.M458I	NM_001127695	NP_001121167	P10619	PPGB_HUMAN	cathepsin A isoform b precursor	458					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCGGCCACATGGTTCCCACCG	0.592			NA											5	51					1.23904e-05	1.46179e-05	0.000602	1	0
BCAS4	55653	broad.mit.edu	37	20	49493042	49493042	+	Silent	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:49493042C>A	uc002xvq.2	+	6	670	c.606C>A	c.(604-606)GCC>GCA	p.A202A	BCAS4_uc002xvr.2_Missense_Mutation_p.P170H|BCAS4_uc002xvs.2_Missense_Mutation_p.P125H	NM_017843	NP_060313	Q8TDM0	BCAS4_HUMAN	breast carcinoma amplified sequence 4 isoform a	202						cytoplasm					0						GCACCGGTGCCCGTGACGTAC	0.562			NA											6	206					0.00198382	0.00217736	0.001984	1	0
ATP9A	10079	broad.mit.edu	37	20	50234086	50234086	+	Silent	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:50234086T>A	uc002xwg.1	-	22	2358	c.2358A>T	c.(2356-2358)GGA>GGT	p.G786G	ATP9A_uc010gih.1_Silent_p.G650G|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	786	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						CGTCATTGCCTCCGTCCCCTG	0.507			NA											5	36					0	0	0.000602	0	0
ZNF512B	57473	broad.mit.edu	37	20	62592756	62592756	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr20:62592756G>T	uc002yhl.1	-	16	2387	c.2333C>A	c.(2332-2334)GCC>GAC	p.A778D		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	778					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGCCAGGTGGGCCCCCTGCAA	0.597			NA											13	228					9.31168e-06	1.10686e-05	0.001855	1	0
SGOL1	151648	broad.mit.edu	37	3	20215786	20215786	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:20215786C>T	uc003cbs.2	-	6	1424	c.1237G>A	c.(1237-1239)GAT>AAT	p.D413N	SGOL1_uc003cbr.2_Intron|SGOL1_uc010hfa.2_Intron|SGOL1_uc003cbt.2_Intron|SGOL1_uc003cbu.2_Missense_Mutation_p.D413N|SGOL1_uc003cbv.2_Intron|SGOL1_uc003cbw.2_Intron|SGOL1_uc003cbx.2_Intron|SGOL1_uc003cby.2_Intron|SGOL1_uc003cbz.2_Missense_Mutation_p.D413N|SGOL1_uc003cca.2_Missense_Mutation_p.D413N|SGOL1_uc003ccb.2_Intron|SGOL1_uc003ccc.2_Intron	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	413					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						TCTTTTTCATCTGTGTATTTC	0.408			NA											29	109					0	0	0.010818	0	0
RARB	5915	broad.mit.edu	37	3	25502745	25502745	+	Silent	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:25502745T>C	uc011awl.1	+	2	306	c.240T>C	c.(238-240)CCT>CCC	p.P80P	RARB_uc003cdi.1_5'UTR|RARB_uc003cdh.2_Silent_p.P73P	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	80	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CTCCACTTCCTCCCCCTCGAG	0.507			NA											3	122					0	0	0.004672	0	0
TOP2B	7155	broad.mit.edu	37	3	25675377	25675377	+	Silent	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:25675377T>C	uc011awn.1	-	8	1024	c.981A>G	c.(979-981)AAA>AAG	p.K327K	TOP2B_uc003cdj.2_Silent_p.K322K	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	327					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCTGGAATCCTTTTTCACTCA	0.348			NA											3	175					0	0	0.001168	0	0
ARPP21	10777	broad.mit.edu	37	3	35770882	35770882	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:35770882T>C	uc003cgb.2	+	15	1577	c.1313T>C	c.(1312-1314)GTG>GCG	p.V438A	ARPP21_uc003cga.2_Missense_Mutation_p.V384A|ARPP21_uc011axy.1_Missense_Mutation_p.V404A|ARPP21_uc003cgf.2_Missense_Mutation_p.V239A|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	438						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GTCTCAGGTGTGGCAGCTGGC	0.592			NA											17	65					0	0	0.007413	0	0
GOLGA4	2803	broad.mit.edu	37	3	37379191	37379191	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:37379191A>T	uc003cgv.2	+	19	6666	c.6362A>T	c.(6361-6363)GAT>GTT	p.D2121V	GOLGA4_uc003cgw.2_Missense_Mutation_p.D2136V|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.D2002V	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2121	Potential.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTAATCAGTGATTCGAAATTG	0.378			NA											16	47					0	0	0.006122	0	0
SCN10A	6336	broad.mit.edu	37	3	38764951	38764951	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:38764951G>T	uc003ciq.2	-	18	3322	c.3322C>A	c.(3322-3324)CTG>ATG	p.L1108M		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1108					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGTTCTTCCAGGTCATCTGCC	0.473			NA											11	38					3.07112e-06	3.69237e-06	0.010729	1	0
ALS2CL	259173	broad.mit.edu	37	3	46712527	46712527	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:46712527C>T	uc003cqa.1	-	26	2999	c.2809G>A	c.(2809-2811)GAC>AAC	p.D937N	ALS2CL_uc003cpx.1_Missense_Mutation_p.D284N|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.D452N|ALS2CL_uc003cqb.1_Missense_Mutation_p.D937N|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	937	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGCCTCATGTCTTCTTTCTGG	0.592			NA											4	143					0	0	0.009096	0	0
SCAP	22937	broad.mit.edu	37	3	47468957	47468957	+	Missense_Mutation	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:47468957T>G	uc003crh.1	-	5	866	c.611A>C	c.(610-612)CAG>CCG	p.Q204P	SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	204	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GGCTGAAGTCTGCAGGGTTTT	0.527	Pancreas(149;978 1908 29304 37806 46700)		NA											3	139					0	0	0.009096	0	0
AMIGO3	386724	broad.mit.edu	37	3	49756821	49756821	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:49756821G>A	uc003cxj.2	-	1	418	c.78C>T	c.(76-78)TTC>TTT	p.F26F	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	26	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CACGGGGCGGGAAACCCTCGG	0.642			NA									OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	85					0	0	0.000602	0	0
IP6K1	9807	broad.mit.edu	37	3	49764843	49764843	+	Silent	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:49764843A>T	uc003cxm.1	-	6	1353	c.1038T>A	c.(1036-1038)GCT>GCA	p.A346A	IP6K1_uc003cxn.1_Silent_p.A181A|IP6K1_uc011bcv.1_Silent_p.A181A|IP6K1_uc003cxo.2_3'UTR	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	346					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						GGCAGGACTCAGCCCGGCACT	0.627			NA											10	37					0	0	0.008291	0	0
RBM5	10181	broad.mit.edu	37	3	50147085	50147085	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:50147085G>A	uc003cyg.2	+	15	1390	c.1242G>A	c.(1240-1242)CAG>CAA	p.Q414Q	RBM5_uc011bdj.1_Silent_p.Q358Q|RBM5_uc011bdk.1_Silent_p.Q242Q	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	414	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAGTCCTCAGCTGTATAATC	0.488			NA											56	131					0	0	0.01441	0	0
ACY1	95	broad.mit.edu	37	3	52022801	52022801	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:52022801G>C	uc003dcp.2	+	14	1082	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	ACY1_uc011bea.1_Missense_Mutation_p.E431Q|ACY1_uc003dcq.2_Missense_Mutation_p.E341Q	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	341					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	TCTGGAGCCTGAGATCATGCC	0.408			NA											12	328					0	0	0.00499	0	0
CACNA1D	776	broad.mit.edu	37	3	53808688	53808688	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:53808688G>T	uc003dgv.3	+	34	4348	c.4185G>T	c.(4183-4185)GCG>GCT	p.A1395A	CACNA1D_uc003dgu.3_Silent_p.A1415A|CACNA1D_uc003dgy.3_Silent_p.A1380A|CACNA1D_uc003dgw.3_Silent_p.A1062A|CACNA1D_uc003dgx.1_Silent_p.A571A	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1395	IV.|Extracellular (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCCCCAGGCGGTGCTGCTGC	0.542			NA											13	50					1.37285e-15	1.93923e-15	0.004007	1	0
CBLB	868	broad.mit.edu	37	3	105439010	105439010	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:105439010C>T	uc003dwc.2	-	10	1610	c.1288G>A	c.(1288-1290)GAT>AAT	p.D430N	CBLB_uc011bhi.1_Missense_Mutation_p.D452N|CBLB_uc003dwd.1_Missense_Mutation_p.D430N|CBLB_uc003dwe.1_Missense_Mutation_p.D430N|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	430					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						GAGCCTTCATCTCTTGGATCA	0.483	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								3	20					0	0	0.009096	0	0
ATP6V1A	523	broad.mit.edu	37	3	113517288	113517288	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:113517288G>T	uc003eao.2	+	12	1555	c.1489G>T	c.(1489-1491)GGA>TGA	p.G497*	ATP6V1A_uc011bik.1_Nonsense_Mutation_p.G464*	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	497					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						ACAGCTTGTGGGAAAGGTGAG	0.428			NA											12	59					1.5842e-08	2.04518e-08	0.001855	1	0
SLITRK3	22865	broad.mit.edu	37	3	164908563	164908563	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:164908563A>T	uc003fej.3	-	2	500	c.56T>A	c.(55-57)CTT>CAT	p.L19H	SLITRK3_uc003fek.2_Missense_Mutation_p.L19H	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	19						integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TGTGCTTAGAAGAATTATCCA	0.418			NA								HNSCC(40;0.11)			24	44					0	0	0.003954	0	0
PRKCI	5584	broad.mit.edu	37	3	169998966	169998966	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr3:169998966G>A	uc003fgs.2	+	10	1133	c.895G>A	c.(895-897)GTA>ATA	p.V299I		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	299	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TATTGATTGGGTACAGACAGA	0.368			NA											3	117					0	0	0.009096	0	0
PROM1	8842	broad.mit.edu	37	4	16025961	16025961	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:16025961G>T	uc003goo.2	-	6	863	c.651C>A	c.(649-651)GCC>GCA	p.A217A	PROM1_uc003gor.2_Silent_p.A217A|PROM1_uc003gos.2_Silent_p.A208A|PROM1_uc003got.2_Silent_p.A217A|PROM1_uc003gou.2_Silent_p.A208A|PROM1_uc003gop.2_Silent_p.A208A|PROM1_uc003goq.3_Silent_p.A208A|PROM1_uc010iec.1_Silent_p.A95A	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	217	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						TGTTGTACTGGGCCAATATAT	0.358			NA											7	58					9.70103e-10	1.28938e-09	0.008291	1	0
UCHL1	7345	broad.mit.edu	37	4	41270013	41270013	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:41270013A>G	uc003gvo.2	+	9	691	c.595A>G	c.(595-597)AAG>GAG	p.K199E	UCHL1_uc003gvp.2_Missense_Mutation_p.K118E|UCHL1_uc003gvq.2_Missense_Mutation_p.K118E|UCHL1_uc003gvr.2_Missense_Mutation_p.K118E|UCHL1_uc003gvs.2_Missense_Mutation_p.K118E	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	199					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|skin(1)	2						GGACGCTGCCAAGGTCTGCAG	0.493			NA											7	36					0	0	0.001984	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895397	42895397	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:42895397G>T	uc003gwt.2	+	1	114	c.114G>T	c.(112-114)CCG>CCT	p.P38P		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	38			P -> L (in DFNB25).		cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						ATGGGCAACCGTCAGGCTCTC	0.517			NA											18	181					2.94398e-08	3.75447e-08	0.007413	1	0
SMR3A	26952	broad.mit.edu	37	4	71232466	71232466	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:71232466C>G	uc003hfg.1	+	3	241	c.160C>G	c.(160-162)CAT>GAT	p.H54D	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	54	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				TCCACCACCCCATCCTCCACC	0.572			NA											50	118					0	0	0.01441	0	0
MUC7	4589	broad.mit.edu	37	4	71347185	71347185	+	Missense_Mutation	SNP	T	T	C	rs79807294	by1000genomes	TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:71347185T>C	uc011cat.1	+	4	1012	c.724T>C	c.(724-726)TCT>CCT	p.S242P	MUC7_uc011cau.1_Missense_Mutation_p.S242P|MUC7_uc003hfj.2_Missense_Mutation_p.S242P|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	242	Thr-rich.|4.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.592			NA											12	223					0	0	0.003163	0	0
CDS1	1040	broad.mit.edu	37	4	85566417	85566417	+	Silent	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:85566417A>C	uc011ccv.1	+	12	1693	c.1195A>C	c.(1195-1197)AGA>CGA	p.R399R	CDS1_uc010ike.1_Silent_p.R163R	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	399					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GATAATGGACAGATTTGATTG	0.299			NA											30	76					0	0	0.004289	0	0
PTPN13	5783	broad.mit.edu	37	4	87694047	87694047	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:87694047C>G	uc003hpz.2	+	32	5765	c.5285C>G	c.(5284-5286)ACT>AGT	p.T1762S	PTPN13_uc003hpy.2_Missense_Mutation_p.T1767S|PTPN13_uc003hqa.2_Missense_Mutation_p.T1743S|PTPN13_uc003hqb.2_Missense_Mutation_p.T1571S|PTPN13_uc003hqc.1_Missense_Mutation_p.T128S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1762						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCTGAACCAACTAGACAAGAA	0.373			NA											12	38					0	0	0.013537	0	0
C4orf37	285555	broad.mit.edu	37	4	98480259	98480259	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:98480259C>G	uc003htt.1	-	11	1420	c.1330G>C	c.(1330-1332)GAG>CAG	p.E444Q		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	444											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		TTCTTTTTCTCCTGGGATATC	0.274			NA											10	88					0	0	0.010729	0	0
ADH1A	124	broad.mit.edu	37	4	100208053	100208053	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:100208053G>T	uc003hur.1	-	3	284	c.213C>A	c.(211-213)GCC>GCA	p.A71A	uc003hum.1_RNA|ADH1A_uc011ceg.1_Silent_p.A71A|ADH1A_uc010ilf.1_5'Flank|ADH1A_uc010ilg.1_Silent_p.A71A	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	71					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCACGATGCCGGCTGCCTCAT	0.507			NA											37	173					4.92203e-23	7.17795e-23	0.00623	1	0
DKK2	27123	broad.mit.edu	37	4	107845352	107845352	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:107845352C>G	uc003hyi.2	-	4	1244	c.539G>C	c.(538-540)GGA>GCA	p.G180A	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	180					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GCAGGGGTCTCCTTCATGCCC	0.423			NA											3	31					0	0	0.009096	0	0
ANK2	287	broad.mit.edu	37	4	114275689	114275689	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:114275689A>T	uc003ibe.3	+	38	6015	c.5915A>T	c.(5914-5916)CAA>CTA	p.Q1972L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.Q1987L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1939	Repeat-rich region.|Repeat A.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACAGAAAAGCAACCACCTGTA	0.498			NA											6	139					0	0	0.001168	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590612	125590612	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:125590612C>G	uc003ifg.3	-	3	4086	c.3820G>C	c.(3820-3822)GAA>CAA	p.E1274Q	ANKRD50_uc011cgo.1_Missense_Mutation_p.E1095Q|ANKRD50_uc010inw.2_Missense_Mutation_p.E1274Q	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1274	Ser-rich.									central_nervous_system(1)	1						GCAGAATTTTCTGATTTCCCC	0.388			NA											54	217					0	0	0.01441	0	0
C4orf27	54969	broad.mit.edu	37	4	170674954	170674954	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr4:170674954T>A	uc003isl.3	-	2	146	c.81A>T	c.(79-81)AAA>AAT	p.K27N		NM_017867	NP_060337	Q9NWY4	CD027_HUMAN	hypothetical protein LOC54969	27						nucleus				ovary(1)|pancreas(1)	2		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		CTTCACAGAATTTACTTTTCT	0.348			NA											4	47					0	0	0.000602	0	0
ADCY2	108	broad.mit.edu	37	5	7724663	7724663	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:7724663G>C	uc003jdz.1	+	13	1776	c.1709G>C	c.(1708-1710)TGG>TCG	p.W570S	ADCY2_uc011cmo.1_Missense_Mutation_p.W390S	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	570	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TCCAGGCAATGGCTCAAGTCT	0.333			NA											6	72					0	0	0.00308	0	0
PRDM9	56979	broad.mit.edu	37	5	23509169	23509169	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:23509169G>T	uc003jgo.2	+	2	209	c.27G>T	c.(25-27)GAG>GAT	p.E9D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	9					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCCAAGAGGAGAGCCCAGAAG	0.567			NA								HNSCC(3;0.000094)			15	38					1.50039e-11	2.06386e-11	0.012319	1	0
TTC33	23548	broad.mit.edu	37	5	40730380	40730380	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:40730380T>A	uc003jma.2	-	3	435	c.287A>T	c.(286-288)TAC>TTC	p.Y96F	TTC33_uc011cpm.1_Intron|TTC33_uc010ivg.2_Intron	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	96	TPR 2.						binding			ovary(1)	1						TTTCATCTCGTATAGGGTAGC	0.358			NA											5	86					0	0	0.000602	0	0
FST	10468	broad.mit.edu	37	5	52779494	52779494	+	Silent	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:52779494A>G	uc003jpd.2	+	3	465	c.438A>G	c.(436-438)CTA>CTG	p.L146L	FST_uc003jpc.2_Silent_p.L146L	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	146	Kazal-like 1.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				GTGCACTCCTAAAGGCAAGAT	0.542			NA											9	46					0	0	0.008291	0	0
MAST4	375449	broad.mit.edu	37	5	66462786	66462786	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:66462786C>T	uc003jut.1	+	28	7280	c.7212C>T	c.(7210-7212)CGC>CGT	p.R2404R	MAST4_uc003juw.2_Silent_p.R2332R|MAST4_uc003jux.2_Silent_p.R157R	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	2596						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		ACACTGACCGCCCCATCTCTC	0.587			NA											3	31					0	0	0.004672	0	0
RASA1	5921	broad.mit.edu	37	5	86645175	86645175	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:86645175A>G	uc003kiw.2	+	8	1365	c.1247A>G	c.(1246-1248)TAT>TGT	p.Y416C	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.Y239C|RASA1_uc011ctv.1_Missense_Mutation_p.Y249C|RASA1_uc011ctw.1_Missense_Mutation_p.Y250C|RASA1_uc010jaw.2_Missense_Mutation_p.Y238C	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	416	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GGCCGGTATTATAACAGGTAA	0.303			NA											3	68					0	0	0.004672	0	0
CAMK4	814	broad.mit.edu	37	5	110819868	110819868	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:110819868G>C	uc011cvj.1	+	12	1225	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	CAMK4_uc003kpf.2_Missense_Mutation_p.E376Q|CAMK4_uc010jbv.2_Missense_Mutation_p.E179Q|CAMK4_uc003kpg.2_Missense_Mutation_p.E67Q	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	376					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TCCAGAAGGAGAGAAAATTCA	0.522			NA											8	83					0	0	0.004482	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202891	140202891	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:140202891G>T	uc003lhl.2	+	1	1531	c.1531G>T	c.(1531-1533)GCG>TCG	p.A511S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A511S|PCDHA5_uc003lhj.1_Missense_Mutation_p.A511S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	511	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGGTGCACGCGGAGAGCGG	0.706			NA											13	120					1.05317e-09	1.38807e-09	0.00245	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140710575	140710575	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:140710575C>G	uc003lji.1	+	1	324	c.324C>G	c.(322-324)ATC>ATG	p.I108M	PCDHGA1_uc011dan.1_Missense_Mutation_p.I108M	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	108	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTAATATCCTTGTTGAGG	0.443			NA											19	144					0	0	0.012319	0	0
PRELID2	153768	broad.mit.edu	37	5	145176111	145176111	+	Splice_Site	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:145176111C>A	uc003lnp.1	-	6	458	c.405_splice	c.e6-1	p.W135_splice	PRELID2_uc003lnq.1_Splice_Site_p.W123_splice|PRELID2_uc003lno.1_Splice_Site_p.W94_splice|PRELID2_uc003lnr.1_Intron	NM_182960	NP_892005	Q8N945	PRLD2_HUMAN	PRELI domain containing 2 isoform a												0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAACTCTGTCCTGCAAAAAAA	0.368			NA											10	87					1.76689e-08	2.26249e-08	0.006214	1	0
MED7	9443	broad.mit.edu	37	5	156566362	156566362	+	Missense_Mutation	SNP	T	T	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:156566362T>A	uc010jik.2	-	2	473	c.81A>T	c.(79-81)CAA>CAT	p.Q27H	MED7_uc003lwm.3_Missense_Mutation_p.Q27H	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	27					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTAAGCCTTCTTGAATATTTT	0.428			NA											7	78					0	0	0.00308	0	0
SLIT3	6586	broad.mit.edu	37	5	168244397	168244397	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr5:168244397C>A	uc003mab.2	-	8	1121	c.701G>T	c.(700-702)CGG>CTG	p.R234L	SLIT3_uc010jjg.2_Missense_Mutation_p.R234L|SLIT3_uc010jji.2_Missense_Mutation_p.R234L|SLIT3_uc003mac.1_Missense_Mutation_p.R31L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	234	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCAACTGTCCGTCGCTGTCG	0.612	Ovarian(29;311 847 10864 17279 24903)		NA											4	60					5.9392e-07	7.308e-07	0.001168	1	0
FOXQ1	94234	broad.mit.edu	37	6	1313369	1313369	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:1313369G>A	uc003mtl.3	+	1	695	c.430G>A	c.(430-432)GAG>AAG	p.E144K		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	144	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		GACGCTGGCGGAGATCAACGA	0.642			NA											6	49					0	0	0.001984	0	0
GMPR	2766	broad.mit.edu	37	6	16254832	16254832	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:16254832G>A	uc003nbs.2	+	4	445	c.331G>A	c.(331-333)GAA>AAA	p.E111K		NM_006877	NP_006868	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	111	NADP (By similarity).				nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				GAATGATCTGGAAAAGATGAC	0.453			NA											53	91					0	0	0.01441	0	0
HIST1H2BO	8348	broad.mit.edu	37	6	27861512	27861512	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:27861512C>A	uc003nkc.1	+	1	310	c.272C>A	c.(271-273)ACC>AAC	p.T91N	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	91					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCGACCATCACCTCCAGGGAG	0.627			NA											10	115					9.70103e-10	1.28938e-09	0.008291	1	0
B3GAT2	135152	broad.mit.edu	37	6	71665781	71665781	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:71665781C>A	uc003pfv.2	-	1	1008	c.352G>T	c.(352-354)GAC>TAC	p.D118Y	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.D118Y	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	118	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GCCGCCGCGTCCTCCACCAGG	0.731			NA											5	31					0.000602214	0.000667949	0.000602	1	0
ME1	4199	broad.mit.edu	37	6	83963432	83963432	+	Missense_Mutation	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:83963432A>C	uc003pjy.2	-	7	836	c.730T>G	c.(730-732)TTT>GTT	p.F244V	ME1_uc011dzb.1_Missense_Mutation_p.F169V|ME1_uc011dzc.1_Missense_Mutation_p.F78V	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	244					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAATCTTCAAACTGAATAAGG	0.308			NA											14	95					0	0	0.003163	0	0
SCML4	256380	broad.mit.edu	37	6	108066250	108066250	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:108066250G>T	uc010kdf.2	-	5	836	c.585C>A	c.(583-585)AGC>AGA	p.S195R	SCML4_uc003prz.3_Missense_Mutation_p.S137R|SCML4_uc011eam.1_Missense_Mutation_p.S195R|SCML4_uc003psa.3_Missense_Mutation_p.S166R	NM_198081	NP_932347	Q8N228	SCML4_HUMAN	sex comb on midleg-like 4	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		CGCACAGGAGGCTTCGGCACA	0.592			NA											9	46					0.000274275	0.000305289	0.004482	1	0
NKAIN2	154215	broad.mit.edu	37	6	124979407	124979407	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:124979407G>C	uc003pzo.2	+	4	626	c.349G>C	c.(349-351)GTG>CTG	p.V117L	NKAIN2_uc003pzn.1_Missense_Mutation_p.V117L|NKAIN2_uc003pzp.2_Missense_Mutation_p.V116L|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Missense_Mutation_p.V27L	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	117						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		AGGATGTACGGTGACGTCAGT	0.493			NA											8	73					0	0	0.004482	0	0
MYB	4602	broad.mit.edu	37	6	135515583	135515583	+	Silent	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:135515583A>T	uc003qfc.2	+	8	1132	c.933A>T	c.(931-933)GGA>GGT	p.G311G	MYB_uc003qfh.2_Silent_p.G311G|MYB_uc003qfi.2_Silent_p.G311G|MYB_uc010kgi.2_Silent_p.G311G|MYB_uc003qfq.2_Silent_p.G311G|MYB_uc010kgj.2_Intron|MYB_uc003qfo.2_Silent_p.G311G|MYB_uc003qfu.2_Silent_p.G311G|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Silent_p.G123G|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Silent_p.G311G|MYB_uc003qgd.1_Silent_p.G123G|MYB_uc003qge.1_5'Flank	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	311	Transcriptional activation domain.				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		AGCTAAAAGGACAGCAGGTGC	0.408			NA	T	NFIB	adenoid cystic carcinoma								4	51					0	0	0.009096	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599520	136599520	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:136599520T>C	uc003qgx.1	-	4	752	c.499A>G	c.(499-501)AAA>GAA	p.K167E	BCLAF1_uc003qgw.1_Missense_Mutation_p.K167E|BCLAF1_uc003qgy.1_Missense_Mutation_p.K165E|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.K165E	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	167					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCAGCTTTTTTGGTTTGTTTT	0.423	Colon(142;1534 1789 5427 7063 28491)		NA											7	198					0	0	0.00308	0	0
NMBR	4829	broad.mit.edu	37	6	142399902	142399902	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:142399902G>T	uc003qiu.2	-	2	702	c.561C>A	c.(559-561)ATC>ATA	p.I187I		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	187	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CCAAGCTACTGATGCGAGCCA	0.488			NA											8	165					0.00448238	0.0049026	0.004482	1	0
STXBP5	134957	broad.mit.edu	37	6	147581767	147581767	+	Silent	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:147581767C>T	uc003qlz.2	+	5	609	c.448C>T	c.(448-450)CTG>TTG	p.L150L	STXBP5_uc010khz.1_Silent_p.L150L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_5'UTR	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	150	WD 3.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ATTTTGCCATCTGCCTTTCCA	0.363			NA											4	74					0	0	0.000602	0	0
TAB2	23118	broad.mit.edu	37	6	149699976	149699976	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr6:149699976C>G	uc003qmj.2	+	3	1103	c.925C>G	c.(925-927)CAT>GAT	p.H309D	TAB2_uc011eec.1_Missense_Mutation_p.H277D|TAB2_uc010kia.1_Missense_Mutation_p.H309D|TAB2_uc010kib.1_Missense_Mutation_p.H309D|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	309					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						GTCTTCTGCCCATAGCCAATA	0.418			NA											18	80					0	0	0.008871	0	0
UNCX	340260	broad.mit.edu	37	7	1275566	1275566	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:1275566C>A	uc011jvw.1	+	3	549	c.549C>A	c.(547-549)AGC>AGA	p.S183R		NM_001080461	NP_001073930	A6NJT0	UNC4_HUMAN	UNC homeobox	183					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CCACGTGCAGCGGCGAGCCCA	0.637			NA											4	20					0.00909568	0.00974537	0.009096	1	0
MEOX2	4223	broad.mit.edu	37	7	15652018	15652018	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:15652018G>A	uc003stc.2	-	3	1190	c.909C>T	c.(907-909)CAC>CAT	p.H303H	MEOX2_uc011jxw.1_Silent_p.H303H	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	303					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TATATCATAAGTGCGCATGCT	0.483	Esophageal Squamous(140;197 1769 16409 18257 29929)		NA											29	65					0	0	0.012213	0	0
GBAS	2631	broad.mit.edu	37	7	56045919	56045919	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:56045919C>G	uc003tre.1	+	2	201	c.193C>G	c.(193-195)CTA>GTA	p.L65V	GBAS_uc003trf.1_Missense_Mutation_p.L65V	NM_001483	NP_001474	O75323	NIPS2_HUMAN	nipsnap homolog 2	65						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			central_nervous_system(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCCAATCTCCTAGCCAAAAA	0.398			NA											7	114					0	0	0.006214	0	0
PCLO	27445	broad.mit.edu	37	7	82546079	82546079	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:82546079G>T	uc003uhx.2	-	7	11512	c.11223C>A	c.(11221-11223)AGC>AGA	p.S3741R	PCLO_uc003uhv.2_Missense_Mutation_p.S3741R|PCLO_uc010lec.2_Missense_Mutation_p.S706R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3672					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGCCCATTGTGCTGAATGTGG	0.468			NA											9	77					0.000274275	0.000305289	0.004482	1	0
CLDN12	9069	broad.mit.edu	37	7	90042108	90042108	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:90042108A>T	uc003ukp.2	+	5	754	c.118A>T	c.(118-120)ACA>TCA	p.T40S	CLDN12_uc003ukq.2_Missense_Mutation_p.T40S|CLDN12_uc010leq.2_Missense_Mutation_p.T40S|CLDN12_uc003ukr.2_Missense_Mutation_p.T40S|CLDN12_uc003uks.2_Missense_Mutation_p.T40S	NM_012129	NP_036261	P56749	CLD12_HUMAN	claudin 12	40	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						ACGATTGATCACATTCAACAG	0.517			NA											4	43					0	0	0.009096	0	0
CPSF4	10898	broad.mit.edu	37	7	99051639	99051639	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:99051639G>A	uc003uqj.2	+	7	764	c.621G>A	c.(619-621)ACG>ACA	p.T207T	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Intron|CPSF4_uc003uqk.2_Intron|CPSF4_uc011kix.1_Intron	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	207					modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TCCAGTTAACGAGTCAGAACT	0.537			NA											9	290					0	0	0.008291	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:114270000G>A	uc003vhb.2	+	5	911	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.Q204Q|FOXP2_uc003vha.2_Silent_p.Q87Q|FOXP2_uc011kmu.1_Silent_p.Q196Q|FOXP2_uc011kmv.1_Silent_p.Q179Q|FOXP2_uc010ljz.1_Silent_p.Q87Q|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Silent_p.Q179Q|FOXP2_uc003vgx.2_Silent_p.Q179Q|FOXP2_uc003vhd.2_Silent_p.Q179Q|FOXP2_uc003vhc.2_Silent_p.Q204Q	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						agcaacaacagcagcagcagc	0.159			NA											3	32					0	0	0.004672	0	0
CFTR	1080	broad.mit.edu	37	7	117267754	117267754	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:117267754C>A	uc003vjd.2	+	22	3779	c.3647C>A	c.(3646-3648)ACA>AAA	p.T1216K	CFTR_uc011knq.1_Missense_Mutation_p.T622K	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1216	Cytoplasmic (Potential).|ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAAGATCTCACAGCAAAATAC	0.423			NA							Cystic_Fibrosis				3	59					2.56e-06	3.08966e-06	0.009096	1	0
TMEM139	135932	broad.mit.edu	37	7	142983074	142983074	+	Silent	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:142983074G>C	uc010lov.2	+	3	163	c.24G>C	c.(22-24)GGG>GGC	p.G8G	CASP2_uc003wco.2_5'Flank|CASP2_uc003wcp.2_5'Flank|CASP2_uc011kta.1_5'Flank|TMEM139_uc003wck.3_Silent_p.G8G|TMEM139_uc003wcl.2_Silent_p.G8G|TMEM139_uc003wcm.2_Silent_p.G8G|TMEM139_uc003wcn.2_Intron	NM_153345	NP_699176	Q8IV31	TM139_HUMAN	transmembrane protein 139 precursor	8						integral to membrane					0	Melanoma(164;0.059)					ACTTACTGGGGAGACTGGAGA	0.552			NA											8	54					0	0	0.00308	0	0
CTAGE4	100128553	broad.mit.edu	37	7	143882715	143882715	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:143882715C>A	uc010lpc.2	+	1	2168	c.2119C>A	c.(2119-2121)CCA>ACA	p.P707T		NM_198495	NP_940897	Q8IX94	CTGE4_HUMAN	CTAGE family, member 4	707	Pro-rich.					integral to membrane					0						TCCATTGTTTCCAGTGGATAC	0.502			NA											9	359					1.08611e-07	1.35763e-07	0.010729	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146536856	146536856	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:146536856G>C	uc003weu.1	+	3	778	c.262G>C	c.(262-264)GAC>CAC	p.D88H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	88	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTTCAGGTTGACTTTGGCAA	0.483			NA								HNSCC(39;0.1)			10	48					0	0	0.010729	0	0
ASB10	136371	broad.mit.edu	37	7	150883748	150883748	+	Splice_Site	SNP	T	T	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:150883748T>G	uc003wjm.1	-	2	578	c.452_splice	c.e2-1	p.R151_splice	ASB10_uc003wjl.1_Splice_Site_p.R151_splice|ASB10_uc003wjn.1_Splice_Site_p.G91_splice	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10						intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCAGAGTCCTAGGGAGGGGA	0.652			NA											4	20					0	0	0.000602	0	0
NCAPG2	54892	broad.mit.edu	37	7	158449054	158449054	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr7:158449054G>A	uc003wnv.1	-	19	2431	c.2286C>T	c.(2284-2286)GTC>GTT	p.V762V	NCAPG2_uc010lqu.1_Silent_p.V554V|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.V762V|NCAPG2_uc011kwe.1_Silent_p.V762V|NCAPG2_uc011kwc.1_Silent_p.V263V|NCAPG2_uc011kwd.1_Silent_p.V205V	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	762					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		ACTCAATGTAGACCAATGCCA	0.453			NA											9	75					0	0	0.008291	0	0
PLEKHA2	59339	broad.mit.edu	37	8	38810885	38810885	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:38810885G>T	uc003xmi.3	+	9	1007	c.773G>T	c.(772-774)GGT>GTT	p.G258V	PLEKHA2_uc011lce.1_Missense_Mutation_p.G208V	NM_021623	NP_067636	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A	258	PH 2.				positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding				0		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)			GTCAAGTCTGGGTAATTGTGT	0.428			NA											12	141					1.05317e-09	1.38807e-09	0.00245	1	0
IKBKB	3551	broad.mit.edu	37	8	42183567	42183567	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:42183567C>G	uc003xow.1	+	20	2243	c.2066C>G	c.(2065-2067)TCT>TGT	p.S689C	IKBKB_uc010lxj.1_Missense_Mutation_p.S466C|IKBKB_uc003xox.1_Missense_Mutation_p.S410C|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.S687C|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.S630C	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	689					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	CAGCTGATGTCTCAGCCCTCC	0.562			NA											27	29					0	0	0.005443	0	0
NCOA2	10499	broad.mit.edu	37	8	71068640	71068640	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:71068640G>C	uc003xyn.1	-	11	2122	c.1960C>G	c.(1960-1962)CCC>GCC	p.P654A		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	654					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AAGGGCGAGGGCTCCATCTGA	0.547			NA	T	RUNXBP2	AML								38	61					0	0	0.007835	0	0
EYA1	2138	broad.mit.edu	37	8	72211347	72211347	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:72211347G>T	uc003xys.3	-	8	1048	c.761C>A	c.(760-762)GCC>GAC	p.A254D	EYA1_uc003xyr.3_Missense_Mutation_p.A249D|EYA1_uc003xyt.3_Missense_Mutation_p.A221D|EYA1_uc010lzf.2_Missense_Mutation_p.A181D|EYA1_uc003xyu.2_Missense_Mutation_p.A254D|EYA1_uc011lfe.1_Missense_Mutation_p.A248D|EYA1_uc003xyv.2_Missense_Mutation_p.A132D	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	254					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGGTAAGTGGCATTGGTGGA	0.483			NA											10	232					4.36969e-10	5.93298e-10	0.001855	1	0
HNF4G	3174	broad.mit.edu	37	8	76470800	76470800	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:76470800C>T	uc003yaq.2	+	8	910	c.640C>T	c.(640-642)CGT>TGT	p.R214C	HNF4G_uc003yar.2_Missense_Mutation_p.R251C	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	214					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TGAGATTAGCCGTGTGGCCAA	0.358			NA											23	757					0	0	0.00333	0	0
ADCY8	114	broad.mit.edu	37	8	131792846	131792846	+	Silent	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:131792846G>T	uc003ytd.3	-	18	3802	c.3546C>A	c.(3544-3546)CCC>CCA	p.P1182P	ADCY8_uc010mds.2_Silent_p.P1051P	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1182	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTCTTCTTGGGGGCAAGATGA	0.512			NA								HNSCC(32;0.087)			6	133					3.59834e-05	4.19806e-05	0.001168	1	0
EPPK1	83481	broad.mit.edu	37	8	144946569	144946569	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr8:144946569C>T	uc003zaa.1	-	1	866	c.853G>A	c.(853-855)GGC>AGC	p.G285S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	285	Plectin 6.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCACGCTGCCGGTACCCTCC	0.682			NA											5	68					0	0	0.000602	0	0
KANK1	23189	broad.mit.edu	37	9	732477	732477	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:732477G>A	uc003zgl.1	+	10	3754	c.3105G>A	c.(3103-3105)GAG>GAA	p.E1035E	KANK1_uc003zgm.2_3'UTR|KANK1_uc003zgn.1_Silent_p.E1035E|KANK1_uc003zgs.1_Silent_p.E877E|KANK1_uc010mgx.1_5'UTR|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1035					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTGAAGAAGAGGAGGAGGAGG	0.468			NA											4	117					0	0	0.000602	0	0
BNC2	54796	broad.mit.edu	37	9	16738407	16738407	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:16738407G>T	uc003zml.2	-	2	220	c.80C>A	c.(79-81)CCA>CAA	p.P27Q	BNC2_uc011lmw.1_Intron|BNC2_uc003zmm.2_Intron|BNC2_uc003zmq.1_Missense_Mutation_p.P41Q|BNC2_uc003zmr.1_Missense_Mutation_p.P27Q|BNC2_uc003zmp.1_Missense_Mutation_p.P27Q|BNC2_uc010mij.1_Intron|BNC2_uc003zmu.1_RNA|BNC2_uc010mim.1_Intron|BNC2_uc010min.1_Intron	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GAAATATGCTGGCCAGTCTTG	0.443			NA											6	40					0.00116845	0.00128692	0.001168	1	0
RPS6	6194	broad.mit.edu	37	9	19379600	19379600	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:19379600G>A	uc003znv.1	-	2	65	c.23C>T	c.(22-24)CCA>CTA	p.P8L	RPS6_uc003znu.1_5'UTR|RPS6_uc003znw.1_5'UTR	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	8					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		GCCAGTGGCTGGGAAGGAGAT	0.443			NA											5	118					0	0	0.00308	0	0
IFNB1	3456	broad.mit.edu	37	9	21077496	21077496	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:21077496C>A	uc003zok.2	-	1	448	c.373G>T	c.(373-375)GAA>TAA	p.E125*		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	125					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	TCCAGTTTTTCTTCCAGGACT	0.433			NA											47	156					5.82388e-19	8.37682e-19	0.01441	1	0
C9orf24	84688	broad.mit.edu	37	9	34379708	34379708	+	Missense_Mutation	SNP	G	G	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:34379708G>C	uc003zuh.1	-	6	943	c.725C>G	c.(724-726)CCG>CGG	p.P242R	KIAA1161_uc003zue.3_5'Flank|C9orf24_uc003zug.1_Missense_Mutation_p.P107R|C9orf24_uc003zuf.1_Missense_Mutation_p.R56G|C9orf24_uc003zui.1_3'UTR	NM_032596	NP_115985	Q8NCR6	CI024_HUMAN	testes development-related NYD-SP22 isoform 1	242										ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		ATTCCGGGCCGGTGCTCGTAG	0.567			NA									OREG0019150	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	96					0	0	0.004482	0	0
UBQLN1	29979	broad.mit.edu	37	9	86294696	86294696	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:86294696C>T	uc004amv.2	-	4	1279	c.705G>A	c.(703-705)ATG>ATA	p.M235I	UBQLN1_uc004amw.2_Missense_Mutation_p.M235I	NM_013438	NP_038466	Q9UMX0	UBQL1_HUMAN	ubiquilin 1 isoform 1	235					apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0						ATACTTGTCTCATTATATCTG	0.323	Melanoma(186;1284 2073 12755 14558 18426)		NA											11	54					0	0	0.008291	0	0
FAM75C1	441452	broad.mit.edu	37	9	90535394	90535394	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:90535394C>T	uc010mqi.2	+	4	601	c.572C>T	c.(571-573)TCC>TTC	p.S191F	FAM75C1_uc004apq.3_Missense_Mutation_p.S174F	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACCTCAGTCTCCTCCCTAAGT	0.612			NA											21	193					0	0	0.010818	0	0
ECM2	1842	broad.mit.edu	37	9	95264875	95264875	+	Silent	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:95264875G>A	uc004ash.2	-	8	1589	c.1524C>T	c.(1522-1524)ACC>ACT	p.T508T	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Silent_p.T486T|ECM2_uc011lty.1_Silent_p.T508T|ECM2_uc004asg.2_Silent_p.T486T|ECM2_uc010mqz.1_Intron	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	508					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						TGATCTTTCTGGTATGATTGA	0.274			NA											6	25					0	0	0.001168	0	0
PTCH1	5727	broad.mit.edu	37	9	98220516	98220516	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:98220516C>T	uc004avk.3	-	18	3135	c.2947G>A	c.(2947-2949)GAC>AAC	p.D983N	PTCH1_uc010mro.2_Missense_Mutation_p.D832N|PTCH1_uc010mrp.2_Missense_Mutation_p.D832N|PTCH1_uc010mrq.2_Missense_Mutation_p.D832N|PTCH1_uc004avl.3_Missense_Mutation_p.D832N|PTCH1_uc010mrr.2_Missense_Mutation_p.D917N|PTCH1_uc004avm.3_Missense_Mutation_p.D982N	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	983	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.I963fs*2(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TCTGAGGTGTCCCGCAAGCCG	0.567			NA							Basal_Cell_Nevus_syndrome				5	22					0	0	0.000602	0	0
NCBP1	4686	broad.mit.edu	37	9	100433388	100433388	+	Missense_Mutation	SNP	G	G	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:100433388G>T	uc004axq.2	+	23	2739	c.2280G>T	c.(2278-2280)CAG>CAT	p.Q760H		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	760					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TAATCCAGCAGTACATGGTGA	0.483	Ovarian(36;879 898 2893 44212 50307)		NA											9	72					1.61879e-10	2.20744e-10	0.013537	1	0
TBC1D2	55357	broad.mit.edu	37	9	101014085	101014085	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:101014085C>T	uc011lvb.1	-	2	673	c.493G>A	c.(493-495)GTC>ATC	p.V165I	TBC1D2_uc004ayq.2_Missense_Mutation_p.V165I|TBC1D2_uc004ayr.2_Intron|TBC1D2_uc004ayo.3_Missense_Mutation_p.V165I	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	165	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGGTGCAGGACGGGCCCATTC	0.637			NA											31	48					0	0	0.012213	0	0
OR13C9	286362	broad.mit.edu	37	9	107380196	107380196	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:107380196C>G	uc011lvr.1	-	1	290	c.290G>C	c.(289-291)TGT>TCT	p.C97S		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGCACTGCACAGCCAGAAAA	0.517			NA											19	111					0	0	0.008871	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136310829	136310829	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:136310829A>G	uc004cdv.3	+	21	3064	c.2620A>G	c.(2620-2622)ACC>GCC	p.T874A	ADAMTS13_uc004cdp.3_Missense_Mutation_p.T101A|ADAMTS13_uc004cdt.1_Missense_Mutation_p.T874A|ADAMTS13_uc004cdu.1_Missense_Mutation_p.T843A|ADAMTS13_uc004cdw.3_Missense_Mutation_p.T874A|ADAMTS13_uc004cdx.3_Missense_Mutation_p.T843A|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Missense_Mutation_p.T544A|ADAMTS13_uc004cds.1_Missense_Mutation_p.T399A|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	874					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GCTGGATGCCACCTCTGCAGG	0.647			NA											12	19					0	0	0.010729	0	0
LCN1	3933	broad.mit.edu	37	9	138413352	138413352	+	Silent	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:138413352C>G	uc004cfz.1	+	1	67	c.9C>G	c.(7-9)CCC>CCG	p.P3P	LCN1_uc004cga.1_Silent_p.P3P	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	3					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		AGATGAAGCCCCTGCTCCTGG	0.652			NA											6	20					0	0	0.004482	0	0
QSOX2	169714	broad.mit.edu	37	9	139110934	139110934	+	Missense_Mutation	SNP	G	G	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chr9:139110934G>A	uc010nbi.2	-	7	936	c.898C>T	c.(898-900)CCT>TCT	p.P300S		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	300					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GGCTTTTCAGGCAAGGGAAGC	0.488			NA											21	30					0	0	0.012319	0	0
RAI2	10742	broad.mit.edu	37	X	17820044	17820044	+	Missense_Mutation	SNP	C	C	A			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:17820044C>A	uc004cyf.2	-	3	657	c.87G>T	c.(85-87)ATG>ATT	p.M29I	RAI2_uc004cyg.2_Missense_Mutation_p.M29I|RAI2_uc010nfa.2_Missense_Mutation_p.M29I|RAI2_uc004cyh.3_Missense_Mutation_p.M29I|RAI2_uc011miy.1_Missense_Mutation_p.M29I	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	29					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					TCAGCTGAGCCATGCCATTCT	0.567			NA											27	89					1.08312e-15	1.53686e-15	0.009535	1	0
HUWE1	10075	broad.mit.edu	37	X	53612061	53612061	+	Missense_Mutation	SNP	T	T	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:53612061T>C	uc004dsp.2	-	40	5314	c.4912A>G	c.(4912-4914)ATT>GTT	p.I1638V	HUWE1_uc004dsn.2_Missense_Mutation_p.I463V	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1638	WWE.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCAGAATCAATAGTGCTATTG	0.473			NA											24	95					0	0	0.00278	0	0
RLIM	51132	broad.mit.edu	37	X	73815767	73815767	+	Missense_Mutation	SNP	C	C	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:73815767C>T	uc004ebu.2	-	3	336	c.46G>A	c.(46-48)GCA>ACA	p.A16T	RLIM_uc004ebw.2_Missense_Mutation_p.A16T	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	16					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CGCTGTGCTGCAGACTGATCA	0.378	Esophageal Squamous(169;1899 1923 14997 18818 32118)		NA											9	31					0	0	0.013537	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912743	77912743	+	Missense_Mutation	SNP	A	A	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:77912743A>G	uc004edc.1	-	2	1471	c.1175T>C	c.(1174-1176)CTG>CCG	p.L392P		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	392							nucleic acid binding|zinc ion binding			ovary(1)	1						CTTCTCTTCCAGGCTGATGCA	0.493			NA											15	58					0	0	0.00499	0	0
GPR174	84636	broad.mit.edu	37	X	78427266	78427266	+	Missense_Mutation	SNP	C	C	G			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:78427266C>G	uc004edg.1	+	1	798	c.762C>G	c.(760-762)TTC>TTG	p.F254L		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	254	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CTTTAGATTTCCTGGTGAAGT	0.388			NA								HNSCC(63;0.18)			9	35					0	0	0.006214	0	0
COL4A6	1288	broad.mit.edu	37	X	107404937	107404937	+	Silent	SNP	A	A	C			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrX:107404937A>C	uc004enw.3	-	42	4351	c.4248T>G	c.(4246-4248)GGT>GGG	p.G1416G	COL4A6_uc004env.3_Silent_p.G1415G|COL4A6_uc011msn.1_Silent_p.G1391G|COL4A6_uc010npk.2_Silent_p.G1358G|COL4A6_uc011msm.1_5'Flank|COL4A6_uc010npj.2_Intron	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1416	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GGCCATCTTTACCGGGGATGC	0.597	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				2	13					0	0	0.004672	0	0
ZFY	7544	broad.mit.edu	37	Y	2829423	2829423	+	Missense_Mutation	SNP	A	A	T			TCGA-91-7771-01A-11D-2167-08	TCGA-91-7771-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	969b8cc9-2632-4be2-9358-681312a36c34	36de470c-ab00-4a9b-8ce8-c3751ef9278e	g.chrY:2829423A>T	uc004fqj.2	+	3	691	c.370A>T	c.(370-372)ATT>TTT	p.I124F	ZFY_uc010nwd.1_Missense_Mutation_p.I124F|ZFY_uc011nan.1_Intron|ZFY_uc010nwe.2_Missense_Mutation_p.I98F	NM_003411	NP_003402	P08048	ZFY_HUMAN	zinc finger protein, Y-linked isoform 1	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCTTCTGACATTACTTCAAC	0.403			NA											24	132					0	0	0.007291	0	0
