Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	ensembl_gene_id	tier	title	header	normal_ref_reads	normal_var_reads	normal_VAF	tumor_ref_reads	tumor_var_reads	tumor_VAF
PRSS16	0	genome.wustl.edu	37	6	27222852	27222852	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	27222852	27222852	G	A	SNP	PRSS16	ENST00000230582	human	ensembl	74_37	+1	known	missense	c.1418	p.C473Y	0.994	pfam_Peptidase_S28	pfam_Peptidase_S28	-	no_errors	PRSS16	HGNC	ENSG00000112812	tier1	-	-	85	0	0.00	66	14	17.50
AKAP12	0	genome.wustl.edu	37	6	151671939	151671939	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	151671939	151671939	G	A	SNP	AKAP12	ENST00000253332	human	ensembl	74_37	+1	known	missense	c.2413	p.V805I	1.000	pfam_Pkinase-A_anch_WSK-motif	pfam_Pkinase-A_anch_WSK-motif,pfam_RII_binding_1	-	no_errors	AKAP12	HGNC	ENSG00000131016	tier1	-	-	13	0	0.00	15	4	20.00
ENSG00000205745	0	genome.wustl.edu	37	7	36124270	36124270	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	36124270	36124270	G	A	SNP	ENSG00000205745	ENST00000381493	human	ensembl	74_37	+1	novel	nonsense	c.272	p.W91*	0.007	NULL	NULL	-	no_errors	PP13004	Uniprot_gn	ENSG00000205745	tier1	-	-	51	0	0.00	29	13	30.95
IRF9	0	genome.wustl.edu	37	14	24632708	24632708	+	Silent	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	14	24632708	24632708	C	A	SNP	IRF9	ENST00000396864	human	ensembl	74_37	+1	known	silent	c.486	p.S162	0.009	NULL	pfam_Interferon_reg_fact_DNA-bd_dom,pfam_Interferon_reg_factor-3,superfamily_SMAD_FHA_domain,smart_Interferon_reg_fact_DNA-bd_dom,prints_Interferon_reg_fact_DNA-bd_dom	-	no_errors	IRF9	HGNC	ENSG00000213928	tier1	-	-	38	0	0.00	28	6	17.65
FLJ26850	0	genome.wustl.edu	37	19	50569594	50569594	+	RNA	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	50569594	50569594	G	T	SNP	FLJ26850	ENST00000527209	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.998	-	-	-	no_errors	CTD-2126E3.1	Clone_based_vega_gene	ENSG00000204666	tier1	-	-	42	0	0.00	30	10	25.00
PTCHD2	0	genome.wustl.edu	37	1	11579882	11579882	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	11579882	11579882	G	A	SNP	PTCHD2	ENST00000294484	human	ensembl	74_37	+1	known	silent	c.2145	p.E715	1.000	pfam_Patched	pfam_Patched,pfam_MMPL_dom,pfscan_SSD	-	no_errors	PTCHD2	HGNC	ENSG00000204624	tier1	-	-	50	0	0.00	25	14	35.90
ANKMY1	0	genome.wustl.edu	37	2	241420382	241420382	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	241420382	241420382	C	T	SNP	ANKMY1	ENST00000272972	human	ensembl	74_37	-1	known	silent	c.2751	p.K917	0.842	pfam_Znf_MYND,pfscan_Znf_MYND	pfam_Ankyrin_rpt,pfam_MORN,pfam_Znf_MYND,superfamily_Ankyrin_rpt-contain_dom,smart_MORN,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_Znf_MYND	-	no_errors	ANKMY1	HGNC	ENSG00000144504	tier1	-	-	133	0	0.00	119	38	24.20
ASMTL	0	genome.wustl.edu	37	X	1554101	1554101	+	RNA	SNP	T	T	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	1554101	1554101	T	A	SNP	ASMTL	ENST00000463763	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	ASMTL	HGNC	ENSG00000169093	tier1	-	-	38	0	0.00	18	10	34.48
SPRED1	0	genome.wustl.edu	37	15	38641683	38641683	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	38641683	38641683	C	T	SNP	SPRED1	ENST00000299084	human	ensembl	74_37	+1	known	nonsense	c.643	p.Q215*	1.000	NULL	pfam_Sprouty,pfam_WH1/EVH1,smart_WH1/EVH1,pfscan_WH1/EVH1	-	no_errors	SPRED1	HGNC	ENSG00000166068	tier1	rs121434314	-	44	0	0.00	16	11	40.74
OR51F2	0	genome.wustl.edu	37	11	4842933	4842933	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	4842933	4842933	C	T	SNP	OR51F2	ENST00000322110	human	ensembl	74_37	+1	known	silent	c.318	p.I106	0.173	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR51F2	HGNC	ENSG00000176925	tier1	-	-	94	0	0.00	63	6	8.70
CDK5RAP3	0	genome.wustl.edu	37	17	46048622	46048622	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	46048622	46048622	C	G	SNP	CDK5RAP3	ENST00000583363	human	ensembl	74_37	+1	known	missense	c.110	p.P37R	0.001	NULL	NULL	-	no_errors	CDK5RAP3	HGNC	ENSG00000108465	tier1	-	-	95	0	0.00	58	30	34.09
SLC20A1	0	genome.wustl.edu	37	2	113414767	113414767	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	113414767	113414767	G	T	SNP	SLC20A1	ENST00000272542	human	ensembl	74_37	+1	known	missense	c.727	p.A243S	1.000	pfam_Phos_transporter	pfam_Phos_transporter	-	no_errors	SLC20A1	HGNC	ENSG00000144136	tier1	-	-	56	0	0.00	46	4	8.00
TCF19	0	genome.wustl.edu	37	6	31130282	31130282	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	31130282	31130282	C	T	SNP	TCF19	ENST00000376255	human	ensembl	74_37	+1	known	missense	c.826	p.P276S	0.927	superfamily_Znf_FYVE_PHD	pfam_FHA_dom,pfam_Znf_PHD-finger,superfamily_SMAD_FHA_domain,superfamily_Znf_FYVE_PHD,smart_FHA_dom,smart_Znf_PHD,pfscan_FHA_dom	-	no_errors	TCF19	HGNC	ENSG00000137310	tier1	-	-	48	0	0.00	26	7	21.21
MIR205HG	0	genome.wustl.edu	37	1	209605637	209605648	+	RNA	DEL	AGCAGCAGCAGC	AGCAGCAGCAGC	-			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	AGCAGCAGCAGC	AGCAGCAGCAGC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	209605637	209605648	AGCAGCAGCAGC	-	DEL	MIR205HG	ENST00000366437	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.000:0.000:0.000:0.000:0.002:0.000:0.000:0.000:0.000:0.000:0.000	-	-	-	no_errors	MIR205HG	HGNC	ENSG00000230937	tier1			NA	NA	NA	NA	NA	NA
LZTS3	0	genome.wustl.edu	37	20	3146263	3146263	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	20	3146263	3146263	C	T	SNP	LZTS3	ENST00000329152	human	ensembl	74_37	-1	known	silent	c.1203	p.K401	1.000	NULL	NULL	-	no_errors	LZTS3	Uniprot_gn	ENSG00000088899	tier1	-	-	42	0	0.00	12	10	45.45
LIFR	0	genome.wustl.edu	37	5	38530658	38530658	+	Nonsense_Mutation	SNP	G	G	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	38530658	38530658	G	C	SNP	LIFR	ENST00000263409	human	ensembl	74_37	-1	known	nonsense	c.92	p.S31*	0.000	NULL	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	-	no_errors	LIFR	HGNC	ENSG00000113594	tier1	-	-	36	0	0.00	17	11	39.29
PDGFRB	0	genome.wustl.edu	37	5	149500489	149500489	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	149500489	149500489	C	A	SNP	PDGFRB	ENST00000261799	human	ensembl	74_37	-1	known	missense	c.2548	p.D850Y	1.000	pirsf_Tyr_kinase_CSF1/PDGF_rcpt,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pirsf_Tyr_kinase_CSF1/PDGF_rcpt,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_Ig_I-set,pfam_Immunoglobulin,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	PDGFRB	HGNC	ENSG00000113721	tier1	-	-	81	0	0.00	47	9	16.07
CR1	0	genome.wustl.edu	37	1	207787796	207787796	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	207787796	207787796	T	C	SNP	CR1	ENST00000367049	human	ensembl	74_37	+1	known	missense	c.6623	p.M2208T	0.000	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	-	no_errors	CR1	HGNC	ENSG00000203710	tier1	rs61822976	-	139	1	0.71	170	15	8.06
ENSG00000225411	0	genome.wustl.edu	37	9	68400455	68400455	+	RNA	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	68400455	68400455	C	T	SNP	ENSG00000225411	ENST00000417843	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.022	-	-	-	no_errors	RP11-764K9.1	Clone_based_vega_gene	ENSG00000225411	tier1	rs200320813	-	14	0	0.00	3	5	62.50
ZNF347	0	genome.wustl.edu	37	19	53645440	53645440	+	Missense_Mutation	SNP	A	A	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	53645440	53645440	A	C	SNP	ZNF347	ENST00000452676	human	ensembl	74_37	-1	known	missense	c.644	p.F215C	0.000	NULL	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF347	HGNC	ENSG00000197937	tier1	-	-	47	0	0.00	32	13	28.89
ABCA8	0	genome.wustl.edu	37	17	66877272	66877272	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	66877272	66877272	T	C	SNP	ABCA8	ENST00000430352	human	ensembl	74_37	-1	known	missense	c.4027	p.T1343A	0.996	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	-	no_errors	ABCA8	HGNC	ENSG00000141338	tier1	-	-	65	0	0.00	38	16	29.63
RGS12	0	genome.wustl.edu	37	4	3318447	3318447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	3318447	3318447	G	T	SNP	RGS12	ENST00000344733	human	ensembl	74_37	+1	known	nonsense	c.550	p.E184*	0.420	NULL	pfam_Raf-like_ras-bd,pfam_RGS_dom,pfam_PDZ,pfam_GoLoco_motif,superfamily_Regulat_G_prot_signal_superfam,superfamily_PDZ,smart_PDZ,smart_PTB/PI_dom,smart_Regulat_G_prot_signal_superfam,smart_Raf-like_ras-bd,smart_GoLoco_motif,pfscan_GoLoco_motif,pfscan_PDZ,pfscan_PTB/PI_dom,pfscan_Raf-like_ras-bd,pfscan_Regulat_G_prot_signal_superfam,prints_RGS_dom	-	no_errors	RGS12	HGNC	ENSG00000159788	tier1	-	-	39	0	0.00	36	4	10.00
DLX6	0	genome.wustl.edu	37	7	96637007	96637007	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	96637007	96637007	A	G	SNP	DLX6	ENST00000518156	human	ensembl	74_37	+1	known	missense	c.494	p.K165R	1.000	superfamily_Homeodomain-like,pfscan_Homeobox_dom	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_HTH_motif,prints_Homeobox_metazoa	-	no_errors	DLX6	HGNC	ENSG00000006377	tier1	-	-	28	0	0.00	13	13	50.00
DPEP1	0	genome.wustl.edu	37	16	89702330	89702330	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	16	89702330	89702330	C	T	SNP	DPEP1	ENST00000261615	human	ensembl	74_37	+1	known	missense	c.119	p.P40L	1.000	pfam_Peptidase_M19	pfam_Peptidase_M19	-	no_errors	DPEP1	HGNC	ENSG00000015413	tier1	-	-	81	0	0.00	37	20	35.09
SPNS3	0	genome.wustl.edu	37	17	4389838	4389838	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	4389838	4389838	C	T	SNP	SPNS3	ENST00000355530	human	ensembl	74_37	+1	known	silent	c.1410	p.Y470	0.998	pfscan_MFS_dom	pfam_MFS,pfam_Sub_transporter,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom	-	no_errors	SPNS3	HGNC	ENSG00000182557	tier1	-	-	46	0	0.00	13	16	55.17
GLTPD2	0	genome.wustl.edu	37	17	4692361	4692361	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	4692361	4692361	C	T	SNP	GLTPD2	ENST00000331264	human	ensembl	74_37	+1	known	missense	c.55	p.P19S	0.009	NULL	pfam_Glycolipid_transfer_prot_dom,superfamily_Glycolipid_transfer_prot_dom	-	no_errors	GLTPD2	HGNC	ENSG00000182327	tier1	-	-	129	1	0.77	64	17	20.99
ENSG00000269939	0	genome.wustl.edu	37	11	82896850	82896850	+	RNA	SNP	T	T	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	82896850	82896850	T	A	SNP	ENSG00000269939	ENST00000602322	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.999	-	-	-	no_errors	RP11-727A23.11	Clone_based_vega_gene	ENSG00000269939	tier1	-	-	56	0	0.00	29	8	21.62
TBC1D29	0	genome.wustl.edu	37	17	28887657	28887657	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	28887657	28887657	G	A	SNP	TBC1D29	ENST00000579181	human	ensembl	74_37	+1	known	missense	c.101	p.C34Y	0.993	superfamily_Rab-GTPase-TBC_dom,pfscan_Rab-GTPase-TBC_dom	superfamily_Rab-GTPase-TBC_dom,pfscan_Rab-GTPase-TBC_dom	-	no_errors	TBC1D29	HGNC	ENSG00000266733	tier1	-	-	131	0	0.00	88	13	12.87
ENSG00000221280	0	genome.wustl.edu	37	12	118604636	118604636	+	RNA	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	118604636	118604636	C	T	SNP	ENSG00000221280	ENST00000408353	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.000	-	-	-	no_errors	AC026366.1	Clone_based_ensembl_gene	ENSG00000221280	tier1	rs61943534	-	13	0	0.00	14	4	22.22
SULF1	0	genome.wustl.edu	37	8	70488399	70488399	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	8	70488399	70488399	C	T	SNP	SULF1	ENST00000260128	human	ensembl	74_37	+1	known	missense	c.367	p.P123S	1.000	pfam_Sulfatase,pfam_Phosphodiest/P_Trfase,superfamily_Alkaline_phosphatase_core,pirsf_Extracellular_sulfatase	pfam_Sulfatase,pfam_Extracellular_sulfatase_C,pfam_Phosphodiest/P_Trfase,superfamily_Alkaline_phosphatase_core,pirsf_Extracellular_sulfatase	-	no_errors	SULF1	HGNC	ENSG00000137573	tier1	-	-	89	0	0.00	28	20	41.67
ATL2	0	genome.wustl.edu	37	2	38536561	38536561	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	38536561	38536561	C	G	SNP	ATL2	ENST00000378954	human	ensembl	74_37	-1	known	missense	c.1031	p.G344A	1.000	pfam_Guanylate-bd_C,superfamily_Guanylate-bd_C	pfam_Guanylate-bd_N,pfam_Guanylate-bd_C,superfamily_P-loop_NTPase,superfamily_Guanylate-bd_C	-	no_errors	ATL2	HGNC	ENSG00000119787	tier1	-	-	27	0	0.00	26	11	29.73
ALK	0	genome.wustl.edu	37	2	29519861	29519861	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	29519861	29519861	C	G	SNP	ALK	ENST00000389048	human	ensembl	74_37	-1	known	missense	c.1710	p.E570D	1.000	pfam_MAM_dom,superfamily_ConA-like_lec_gl_sf,pfscan_MAM_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_MAM_dom,superfamily_Kinase-like_dom,superfamily_ConA-like_lec_gl_sf,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_MAM_dom,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	ALK	HGNC	ENSG00000171094	tier1	-	-	59	0	0.00	35	31	46.97
GLP1R	0	genome.wustl.edu	37	6	39053689	39053689	+	Missense_Mutation	SNP	T	T	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	39053689	39053689	T	A	SNP	GLP1R	ENST00000373256	human	ensembl	74_37	+1	known	missense	c.1232	p.L411Q	0.998	NULL	pfam_GPCR_2_secretin-like,pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like,prints_GPCR_2_GLP1_rcpt,prints_GPCR_2_secretin-like,prints_GPCR_2_GLP1/glucagon_rcpt,prints_GPCR_2_GIP_rcpt	-	no_errors	GLP1R	HGNC	ENSG00000112164	tier1	-	-	74	0	0.00	48	22	31.43
ME1	0	genome.wustl.edu	37	6	83933629	83933629	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	83933629	83933629	G	A	SNP	ME1	ENST00000369705	human	ensembl	74_37	-1	known	silent	c.1299	p.G433	1.000	pfam_Malic_NAD-bd,smart_Malic_NAD-bd	pfam_Malic_NAD-bd,pfam_Malic_N,smart_Malic_NAD-bd,prints_Malic_OxRdtase	-	no_errors	ME1	HGNC	ENSG00000065833	tier1	-	-	20	0	0.00	23	4	14.81
LCA5	0	genome.wustl.edu	37	6	80198915	80198915	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	80198915	80198915	G	A	SNP	LCA5	ENST00000369846	human	ensembl	74_37	-1	known	nonsense	c.1117	p.Q373*	0.000	NULL	NULL	-	no_errors	LCA5	HGNC	ENSG00000135338	tier1	-	-	23	0	0.00	15	13	46.43
ANKLE1	0	genome.wustl.edu	37	19	17397495	17397495	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	17397495	17397495	G	T	SNP	ANKLE1	ENST00000598347	human	ensembl	74_37	+1	putative	missense	c.1765	p.V589L	0.072	NULL	pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,superfamily_Lactate_DH/Glyco_Ohase_4_C,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	-	no_errors	ANKLE1	HGNC	ENSG00000160117	tier1	-	-	16	0	0.00	12	5	29.41
EEF1G	0	genome.wustl.edu	37	11	62339327	62339327	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	62339327	62339327	T	C	SNP	EEF1G	ENST00000378019	human	ensembl	74_37	-1	known	missense	c.368	p.N123S	1.000	pfam_Glutathione_S-Trfase_N,superfamily_Thioredoxin-like_fold	pfam_Transl_elong_EF1_G_con,pfam_Glutathione_S-Trfase_N,pfam_GST_C,superfamily_Transl_elong_EF1_G_con,superfamily_Glutathione-S-Trfase_C-like,superfamily_Thioredoxin-like_fold,pfscan_Transl_elong_EF1_G_con	-	no_errors	EEF1G	HGNC	ENSG00000254772	tier1	-	-	69	0	0.00	30	20	40.00
CYP4F43P	0	genome.wustl.edu	37	2	131187400	131187400	+	RNA	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	131187400	131187400	G	T	SNP	CYP4F43P	ENST00000455215	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.055	-	-	-	no_errors	CYP4F43P	HGNC	ENSG00000239402	tier1	-	-	32	0	0.00	23	6	20.69
SLC4A10	0	genome.wustl.edu	37	2	162735640	162735640	+	Splice_Site	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	162735640	162735640	G	A	SNP	SLC4A10	ENST00000446997	human	ensembl	74_37	+1	known	splice_site	c.949-1	e9-1	1.000	-	-	-	no_errors	SLC4A10	HGNC	ENSG00000144290	tier1	-	-	22	0	0.00	27	12	30.77
SPATA41	0	genome.wustl.edu	37	15	100889473	100889473	+	RNA	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	100889473	100889473	C	G	SNP	SPATA41	ENST00000560282	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	SPATA41	HGNC	ENSG00000189419	tier1	-	-	48	0	0.00	52	11	17.46
CACNA1E	0	genome.wustl.edu	37	1	181686247	181686247	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	181686247	181686247	C	A	SNP	CACNA1E	ENST00000367573	human	ensembl	74_37	+1	known	missense	c.1334	p.A445D	1.000	NULL	pfam_Ion_trans_dom,pfam_VDCC_a1su_IQ,pfam_PKD1_2_channel,pfscan_EF_hand_dom,prints_VDCCAlpha1,prints_VDCC_R_a1su	-	no_errors	CACNA1E	HGNC	ENSG00000198216	tier1	-	-	28	0	0.00	21	14	40.00
NUAK1	0	genome.wustl.edu	37	12	106461409	106461409	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	106461409	106461409	G	T	SNP	NUAK1	ENST00000261402	human	ensembl	74_37	-1	known	missense	c.1157	p.P386H	0.054	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	NUAK1	HGNC	ENSG00000074590	tier1	-	-	45	0	0.00	27	9	25.00
ENTPD8	0	genome.wustl.edu	37	9	140330683	140330683	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	140330683	140330683	A	G	SNP	ENTPD8	ENST00000371506	human	ensembl	74_37	-1	known	missense	c.832	p.Y278H	0.999	pfam_GDA1_CD39_NTPase	pfam_GDA1_CD39_NTPase	-	no_errors	ENTPD8	HGNC	ENSG00000188833	tier1	-	-	103	0	0.00	60	34	36.17
SLC22A20	0	genome.wustl.edu	37	11	65000676	65000676	+	RNA	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	65000676	65000676	C	G	SNP	SLC22A20	ENST00000525437	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.982	-	-	-	no_errors	SLC22A20	HGNC	ENSG00000197847	tier1	-	-	51	0	0.00	46	23	32.86
E2F3	0	genome.wustl.edu	37	6	20481454	20481455	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	20481454	20481455	-	A	INS	E2F3	ENST00000346618	human	ensembl	74_37	+1	known	frame_shift_ins	c.523_524	p.T177fs	1.000:1.000	NULL	pfam_E2F_TDP	-	no_errors	E2F3	HGNC	ENSG00000112242	tier1			30	0	0.00	11	9	45.00
DDX56	0	genome.wustl.edu	37	7	44613318	44613318	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	44613318	44613318	C	T	SNP	DDX56	ENST00000258772	human	ensembl	74_37	-1	known	missense	c.86	p.R29Q	1.000	superfamily_P-loop_NTPase,smart_Helicase_ATP-bd,pfscan_RNA_helicase_DEAD_Q_motif	pfam_DNA/RNA_helicase_DEAD/DEAH_N,pfam_Helicase_C,pfam_Helicase/UvrB_dom,superfamily_P-loop_NTPase,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C,pfscan_RNA_helicase_DEAD_Q_motif	-	no_errors	DDX56	HGNC	ENSG00000136271	tier1	-	-	55	0	0.00	39	14	26.42
TENM4	0	genome.wustl.edu	37	11	78383117	78383117	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	78383117	78383117	G	A	SNP	TENM4	ENST00000278550	human	ensembl	74_37	-1	known	silent	c.5754	p.F1918	0.995	tigrfam_YD	pfam_Ten_N,pfam_EGF_extracell,pfam_YD,superfamily_CarboxyPept-like_regulatory,smart_EG-like_dom,pfscan_EG-like_dom,tigrfam_YD,tigrfam_Rhs_assc_core	-	no_errors	TENM4	HGNC	ENSG00000149256	tier1	-	-	40	0	0.00	28	12	30.00
ZNF469	0	genome.wustl.edu	37	16	88502797	88502797	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	16	88502797	88502797	G	A	SNP	ZNF469	ENST00000437464	human	ensembl	74_37	+1	known	silent	c.8835	p.K2945	0.001	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF469	HGNC	ENSG00000225614	tier1	-	-	89	0	0.00	79	11	12.22
COBL	0	genome.wustl.edu	37	7	51141048	51141048	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	51141048	51141048	C	G	SNP	COBL	ENST00000441453	human	ensembl	74_37	-1	known	missense	c.1131	p.K377N	1.000	NULL	pfam_Cordon-bleu_ubiquitin_domain	-	no_errors	COBL	HGNC	ENSG00000106078	tier1	-	-	24	0	0.00	14	5	26.32
FREM2	0	genome.wustl.edu	37	13	39263070	39263070	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	13	39263070	39263070	A	G	SNP	FREM2	ENST00000280481	human	ensembl	74_37	+1	known	missense	c.1589	p.D530G	1.000	NULL	pfam_Calx_beta,superfamily_Cadherin-like,smart_Calx_beta	-	no_errors	FREM2	HGNC	ENSG00000150893	tier1	-	-	32	0	0.00	16	7	30.43
LOC150776	0	genome.wustl.edu	37	2	132250386	132250386	+	RNA	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	132250386	132250386	T	C	SNP	LOC150776	ENST00000438378	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.004	-	-	-	no_errors	AC093838.4	Clone_based_vega_gene	ENSG00000152117	tier1	-	-	78	0	0.00	58	26	30.95
PHYHIP	0	genome.wustl.edu	37	8	22079120	22079120	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	8	22079120	22079120	C	T	SNP	PHYHIP	ENST00000454243	human	ensembl	74_37	-1	known	missense	c.739	p.D247N	1.000	NULL	superfamily_Fibronectin_type3,pfscan_Fibronectin_type3	-	no_errors	PHYHIP	HGNC	ENSG00000168490	tier1	-	-	46	0	0.00	40	5	11.11
TLE4	0	genome.wustl.edu	37	9	82308573	82308575	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	GTT	GTT					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	82308573	82308575	GTT	-	DEL	TLE4	ENST00000376520	human	ensembl	74_37	+1	known	in_frame_del	c.617_619	p.SL206in_frame_delI	0.000:0.000:0.000	NULL	pfam_Groucho/TLE_N,pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,prints_Groucho_enhance	-	no_errors	TLE4	HGNC	ENSG00000106829	tier1			45	0	0.00	34	18	34.62
CBLB	0	genome.wustl.edu	37	3	105421207	105421207	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	105421207	105421207	G	A	SNP	CBLB	ENST00000264122	human	ensembl	74_37	-1	known	missense	c.1690	p.P564S	0.992	NULL	pfam_Adaptor_Cbl_N_hlx,pfam_Adaptor_Cbl_SH2-like,pfam_Adaptor_Cbl_EF_hand-like,pfam_Znf_C3HC4_RING-type,pfam_UBA/Ts_N,superfamily_Adaptor_Cbl_N_hlx,superfamily_UBA-like,smart_Znf_RING,smart_UBA/transl_elong_EF1B_N_euk,pfscan_UBA/transl_elong_EF1B_N_euk,pfscan_Znf_RING	-	no_errors	CBLB	HGNC	ENSG00000114423	tier1	-	-	74	0	0.00	17	12	41.38
GAPDH	0	genome.wustl.edu	37	12	6647317	6647317	+	Missense_Mutation	SNP	A	A	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	6647317	6647317	A	C	SNP	GAPDH	ENST00000229239	human	ensembl	74_37	+1	known	missense	c.989	p.H330P	1.000	pirsf_GlycerAld/Erythrose_P_DH	pfam_GlycerAld_3-P_DH_cat,pfam_GlycerAld_3-P_DH_NAD(P)-bd,smart_GlycerAld_3-P_DH_NAD(P)-bd,pirsf_GlycerAld/Erythrose_P_DH,prints_GlycerAld/Erythrose_P_DH,tigrfam_Glyceraldehyde-3-P_DH_1	-	no_errors	GAPDH	HGNC	ENSG00000111640	tier1	-	-	25	0	0.00	32	9	21.95
TSSK6	0	genome.wustl.edu	37	19	19626029	19626029	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	19626029	19626029	G	A	SNP	TSSK6	ENST00000360913	human	ensembl	74_37	-1	known	missense	c.208	p.P70S	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	TSSK6	HGNC	ENSG00000178093	tier1	-	-	39	0	0.00	34	15	30.61
UGT3A2	0	genome.wustl.edu	37	5	36039667	36039667	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	36039667	36039667	C	T	SNP	UGT3A2	ENST00000282507	human	ensembl	74_37	-1	known	nonsense	c.987	p.W329*	0.976	pfam_UDP_glucos_trans	pfam_UDP_glucos_trans,pfam_Glyco_trans_28_C	-	no_errors	UGT3A2	HGNC	ENSG00000168671	tier1	-	-	60	0	0.00	56	10	15.15
PHF17	0	genome.wustl.edu	37	4	129792902	129792902	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	129792902	129792902	G	A	SNP	PHF17	ENST00000226319	human	ensembl	74_37	+1	known	missense	c.2014	p.D672N	0.989	NULL	pfam_Enhancer_polycomb-like_N,pfam_Znf_PHD-finger,superfamily_Znf_FYVE_PHD,smart_Znf_PHD,pfscan_Znf_PHD-finger	-	no_errors	PHF17	HGNC	ENSG00000077684	tier1	-	-	22	0	0.00	16	5	23.81
WDR3	0	genome.wustl.edu	37	1	118483749	118483749	+	Silent	SNP	A	A	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	118483749	118483749	A	C	SNP	WDR3	ENST00000349139	human	ensembl	74_37	+1	known	silent	c.792	p.R264	0.292	superfamily_WD40_repeat_dom,pfscan_WD40_repeat_dom	pfam_WD40_repeat,pfam_SSU_processome_Utp12,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,prints_G-protein_beta_WD-40_rep	-	no_errors	WDR3	HGNC	ENSG00000065183	tier1	-	-	31	0	0.00	30	13	30.23
UNC13C	0	genome.wustl.edu	37	15	54630676	54630676	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	54630676	54630676	C	G	SNP	UNC13C	ENST00000260323	human	ensembl	74_37	+1	known	missense	c.4702	p.L1568V	1.000	pfam_Ca-dep_secretion_activator	pfam_Munc13_subgr_dom-2,pfam_Ca-dep_secretion_activator,pfam_C2_dom,pfam_Prot_Kinase_C-like_PE/DAG-bd,superfamily_C2_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_C2_dom,pfscan_C2_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd,prints_C2_dom	-	no_errors	UNC13C	HGNC	ENSG00000137766	tier1	-	-	43	0	0.00	4	21	84.00
DPCR1	0	genome.wustl.edu	37	6	30916955	30916955	+	Missense_Mutation	SNP	G	G	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	30916955	30916955	G	C	SNP	DPCR1	ENST00000462446	human	ensembl	74_37	+1	novel	missense	c.714	p.K238N	0.000	NULL	NULL	-	no_errors	DPCR1	HGNC	ENSG00000168631	tier1	-	-	21	0	0.00	15	4	21.05
ZNF268	0	genome.wustl.edu	37	12	133779947	133779947	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	133779947	133779947	C	A	SNP	ZNF268	ENST00000228289	human	ensembl	74_37	+1	known	missense	c.1675	p.H559N	0.000	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF268	HGNC	ENSG00000090612	tier1	-	-	11	0	0.00	10	11	52.38
HERC2P3	0	genome.wustl.edu	37	15	20644374	20644374	+	RNA	SNP	A	A	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	20644374	20644374	A	T	SNP	HERC2P3	ENST00000426501	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.999	-	-	-	no_errors	HERC2P3	HGNC	ENSG00000180229	tier1	-	-	82	0	0.00	50	19	27.54
MBD3	0	genome.wustl.edu	37	19	1584657	1584657	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	1584657	1584657	G	A	SNP	MBD3	ENST00000156825	human	ensembl	74_37	-1	known	missense	c.290	p.T97M	1.000	superfamily_DNA-bd_dom	pfam_Methyl_CpG_DNA-bd,superfamily_DNA-bd_dom,superfamily_ARM-type_fold,smart_Methyl_CpG_DNA-bd,pfscan_Methyl_CpG_DNA-bd	-	no_errors	MBD3	HGNC	ENSG00000071655	tier1	-	-	49	0	0.00	17	17	50.00
OTOF	0	genome.wustl.edu	37	2	26698260	26698260	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	26698260	26698260	G	A	SNP	OTOF	ENST00000272371	human	ensembl	74_37	-1	known	silent	c.3093	p.I1031	1.000	pfam_C2_dom,superfamily_C2_dom,smart_C2_dom,pfscan_C2_dom	pfam_C2_dom,pfam_Ferlin_B-domain,pfam_FerIin-domain,superfamily_C2_dom,smart_C2_dom,pfscan_C2_dom	-	no_errors	OTOF	HGNC	ENSG00000115155	tier1	-	-	57	0	0.00	46	25	35.21
OTOF	0	genome.wustl.edu	37	2	26698230	26698230	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	26698230	26698230	G	A	SNP	OTOF	ENST00000272371	human	ensembl	74_37	-1	known	silent	c.3123	p.S1041	0.999	pfam_C2_dom,superfamily_C2_dom,smart_C2_dom,pfscan_C2_dom	pfam_C2_dom,pfam_Ferlin_B-domain,pfam_FerIin-domain,superfamily_C2_dom,smart_C2_dom,pfscan_C2_dom	-	no_errors	OTOF	HGNC	ENSG00000115155	tier1	-	-	56	0	0.00	46	37	44.58
ZAK	0	genome.wustl.edu	37	2	174131048	174131048	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	174131048	174131048	G	A	SNP	ZAK	ENST00000375213	human	ensembl	74_37	+1	known	missense	c.1973	p.G658D	1.000	NULL	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_SAM_type1,pfam_SAM_2,superfamily_Kinase-like_dom,superfamily_SAM/pointed,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_SAM,pfscan_SAM,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	MLTK	Uniprot_gn	ENSG00000091436	tier1	-	-	29	0	0.00	31	7	18.42
FOXK2	0	genome.wustl.edu	37	17	80540673	80540673	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	80540673	80540673	C	T	SNP	FOXK2	ENST00000335255	human	ensembl	74_37	+1	known	silent	c.966	p.S322	1.000	pfam_TF_fork_head,smart_TF_fork_head,pfscan_TF_fork_head	pfam_TF_fork_head,pfam_FHA_dom,superfamily_SMAD_FHA_domain,smart_FHA_dom,smart_TF_fork_head,pfscan_FHA_dom,pfscan_TF_fork_head,prints_TF_fork_head	-	no_errors	FOXK2	HGNC	ENSG00000141568	tier1	-	-	30	0	0.00	25	11	30.56
PM20D1	0	genome.wustl.edu	37	1	205811878	205811878	+	Silent	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	205811878	205811878	A	G	SNP	PM20D1	ENST00000367136	human	ensembl	74_37	-1	known	silent	c.829	p.L277	1.000	pfam_Peptidase_M20,pfam_Peptidase_M20_dimer,superfamily_Peptidase_M20_dimer	pfam_Peptidase_M20,pfam_Peptidase_M20_dimer,superfamily_Peptidase_M20_dimer	-	no_errors	PM20D1	HGNC	ENSG00000162877	tier1	-	-	46	0	0.00	33	15	31.25
TUBB4B	0	genome.wustl.edu	37	9	140137556	140137556	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	140137556	140137556	G	A	SNP	TUBB4B	ENST00000340384	human	ensembl	74_37	+1	known	missense	c.886	p.A296T	1.000	pfam_Tubulin/FtsZ_2-layer-sand-dom,superfamily_Tub_FtsZ_C,smart_Tubulin/FtsZ_2-layer-sand-dom,prints_Gamma_tubulin	pfam_Tubulin_FtsZ_GTPase,pfam_Tubulin/FtsZ_2-layer-sand-dom,pfam_Misato_II_tubulin-like,superfamily_Tubulin_FtsZ_GTPase,superfamily_Tub_FtsZ_C,smart_Tubulin_FtsZ_GTPase,smart_Tubulin/FtsZ_2-layer-sand-dom,prints_Beta_tubulin,prints_Tubulin,prints_Epsilon_tubulin,prints_Gamma_tubulin,prints_Delta_tubulin,prints_Alpha_tubulin	-	no_errors	TUBB4B	HGNC	ENSG00000188229	tier1	-	-	136	0	0.00	89	8	8.25
SLC6A7	0	genome.wustl.edu	37	5	149582250	149582250	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	149582250	149582250	C	G	SNP	SLC6A7	ENST00000230671	human	ensembl	74_37	+1	known	missense	c.1071	p.D357E	1.000	pfam_Na/ntran_symport,pfscan_Na/ntran_symport	pfam_Na/ntran_symport,pfscan_Na/ntran_symport,prints_Na/ntran_symport	-	no_errors	SLC6A7	HGNC	ENSG00000011083	tier1	-	-	46	0	0.00	27	12	30.77
PHLDB1	0	genome.wustl.edu	37	11	118513087	118513087	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	118513087	118513087	C	T	SNP	PHLDB1	ENST00000361417	human	ensembl	74_37	+1	known	missense	c.2852	p.P951L	0.998	NULL	pfam_Pleckstrin_homology,superfamily_SMAD_FHA_domain,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	-	no_errors	PHLDB1	HGNC	ENSG00000019144	tier1	-	-	96	0	0.00	64	34	34.69
ZNF733P	0	genome.wustl.edu	37	7	62752551	62752551	+	RNA	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	62752551	62752551	G	A	SNP	ZNF733P	ENST00000331425	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.970	-	-	-	no_errors	ZNF733P	HGNC	ENSG00000185037	tier1	-	-	51	0	0.00	32	6	15.79
CXorf64	0	genome.wustl.edu	37	X	125955076	125955076	+	Missense_Mutation	SNP	A	A	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	125955076	125955076	A	T	SNP	CXorf64	ENST00000371125	human	ensembl	74_37	+1	known	missense	c.455	p.E152V	0.065	NULL	NULL	-	no_errors	CXorf64	HGNC	ENSG00000183631	tier1	-	-	100	0	0.00	79	7	8.14
OPA1	0	genome.wustl.edu	37	3	193372786	193372786	+	Silent	SNP	T	T	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	193372786	193372786	T	A	SNP	OPA1	ENST00000361510	human	ensembl	74_37	+1	known	silent	c.2148	p.T716	1.000	NULL	pfam_Dynamin_GTPase,superfamily_P-loop_NTPase,smart_Dynamin_GTPase,prints_Dynamin_SF	-	no_errors	OPA1	HGNC	ENSG00000198836	tier1	-	-	36	0	0.00	24	10	29.41
UTP3	0	genome.wustl.edu	37	4	71555634	71555634	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	71555634	71555634	C	T	SNP	UTP3	ENST00000254803	human	ensembl	74_37	+1	known	nonsense	c.1240	p.Q414*	1.000	pfam_Sas10_C_dom	pfam_Sas10_C_dom,pfam_Sas10/Utp3/C1D	-	no_errors	UTP3	HGNC	ENSG00000132467	tier1	-	-	21	0	0.00	10	8	42.11
FAM220A	0	genome.wustl.edu	37	7	6370316	6370316	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	6370316	6370316	C	T	SNP	FAM220A	ENST00000313324	human	ensembl	74_37	-1	known	missense	c.470	p.R157H	0.000	NULL	NULL	-	no_errors	FAM220A	HGNC	ENSG00000178397	tier1	-	-	74	0	0.00	30	25	45.45
DGCR2	0	genome.wustl.edu	37	22	19050736	19050736	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	22	19050736	19050736	G	A	SNP	DGCR2	ENST00000263196	human	ensembl	74_37	-1	known	missense	c.604	p.R202C	1.000	superfamily_C-type_lectin_fold,smart_C-type_lectin,pfscan_C-type_lectin	pfam_LDrepeatLR_classA_rpt,superfamily_C-type_lectin_fold,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,smart_C-type_lectin,smart_VWF_C,pfscan_LDrepeatLR_classA_rpt,pfscan_C-type_lectin	-	no_errors	DGCR2	HGNC	ENSG00000070413	tier1	-	-	27	0	0.00	18	15	45.45
BMP8B	0	genome.wustl.edu	37	1	40230633	40230633	+	Missense_Mutation	SNP	T	T	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	40230633	40230633	T	A	SNP	BMP8B	ENST00000397360	human	ensembl	74_37	-1	known	missense	c.721	p.M241L	0.658	NULL	pfam_TGF-b_N	-	no_errors	BMP8B	HGNC	ENSG00000116985	tier1	-	-	43	0	0.00	23	4	14.81
SPACA1	0	genome.wustl.edu	37	6	88768470	88768470	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	88768470	88768470	G	A	SNP	SPACA1	ENST00000237201	human	ensembl	74_37	+1	known	missense	c.404	p.R135K	0.059	NULL	NULL	-	no_errors	SPACA1	HGNC	ENSG00000118434	tier1	-	-	13	0	0.00	18	4	18.18
GCOM1	0	genome.wustl.edu	37	15	57924644	57924644	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	57924644	57924644	C	A	SNP	GCOM1	ENST00000380569	human	ensembl	74_37	+1	known	missense	c.691	p.Q231K	1.000	NULL	NULL	-	no_errors	GCOM1	HGNC	ENSG00000137878	tier1	-	-	189	1	0.53	62	77	55.40
ENSG00000221741	0	genome.wustl.edu	37	5	167297559	167297560	+	RNA	INS	-	-	AT			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	167297559	167297560	-	AT	INS	ENSG00000221741	ENST00000408814	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.001:0.001	-	-	-	no_errors	AC093304.1	Clone_based_ensembl_gene	ENSG00000221741	tier1			9	0	0.00	6	3	33.33
MAGED1	0	genome.wustl.edu	37	X	51640322	51640322	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	51640322	51640322	T	C	SNP	MAGED1	ENST00000375695	human	ensembl	74_37	+1	known	missense	c.1609	p.Y537H	0.998	pfam_MAGE,pfscan_MAGE	pfam_MAGE,pfscan_MAGE	-	no_errors	MAGED1	HGNC	ENSG00000179222	tier1	-	-	43	0	0.00	38	7	15.56
DAGLA	0	genome.wustl.edu	37	11	61504767	61504767	+	Missense_Mutation	SNP	T	T	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	61504767	61504767	T	G	SNP	DAGLA	ENST00000257215	human	ensembl	74_37	+1	known	missense	c.1485	p.F495L	0.999	pfam_Lipase_3	pfam_Lipase_3	-	no_errors	DAGLA	HGNC	ENSG00000134780	tier1	-	-	83	0	0.00	64	31	32.63
MKI67	0	genome.wustl.edu	37	10	129910594	129910594	+	Missense_Mutation	SNP	G	G	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	10	129910594	129910594	G	C	SNP	MKI67	ENST00000368654	human	ensembl	74_37	-1	known	missense	c.1772	p.A591G	0.001	NULL	pfam_K167R,pfam_FHA_dom,superfamily_SMAD_FHA_domain,smart_FHA_dom,pfscan_FHA_dom	-	no_errors	MKI67	HGNC	ENSG00000148773	tier1	-	-	67	0	0.00	16	17	51.52
AKAP3	0	genome.wustl.edu	37	12	4737038	4737038	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	4737038	4737038	C	T	SNP	AKAP3	ENST00000228850	human	ensembl	74_37	-1	known	missense	c.1030	p.V344I	0.915	pfam_AKAP_110_C,smart_AKAP_110	pfam_AKAP_110_C,pfam_RII_binding_1,smart_AKAP_110	-	no_errors	AKAP3	HGNC	ENSG00000111254	tier1	-	-	32	0	0.00	22	32	59.26
SPINK8	0	genome.wustl.edu	37	3	48369805	48369805	+	Silent	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	48369805	48369805	G	T	SNP	SPINK8	ENST00000434006	human	ensembl	74_37	-1	known	silent	c.27	p.I9	0.002	NULL	pfam_Kazal_dom,smart_Kazal_dom	-	no_errors	SPINK8	HGNC	ENSG00000229453	tier1	-	-	52	0	0.00	11	18	62.07
ANKMY1	0	genome.wustl.edu	37	2	241420515	241420515	+	Splice_Site	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	241420515	241420515	C	T	SNP	ANKMY1	ENST00000272972	human	ensembl	74_37	-1	known	splice_site	c.2619-1	e15-1	0.828	-	-	-	no_errors	ANKMY1	HGNC	ENSG00000144504	tier1	-	-	76	0	0.00	83	27	24.55
SERTAD2	0	genome.wustl.edu	37	2	64863377	64863377	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	64863377	64863377	C	T	SNP	SERTAD2	ENST00000313349	human	ensembl	74_37	-1	known	missense	c.629	p.G210D	0.935	NULL	pfam_SERTA,pfscan_SERTA	-	no_errors	SERTAD2	HGNC	ENSG00000179833	tier1	-	-	27	0	0.00	35	5	12.50
TEX11	0	genome.wustl.edu	37	X	69843849	69843849	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	69843849	69843849	G	A	SNP	TEX11	ENST00000344304	human	ensembl	74_37	-1	known	missense	c.1747	p.L583F	0.008	NULL	pfam_Meiosis_specific_SPO22,smart_TPR_repeat	-	no_errors	TEX11	HGNC	ENSG00000120498	tier1	-	-	58	0	0.00	38	4	9.52
ALS2CR11	0	genome.wustl.edu	37	2	202358884	202358884	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	202358884	202358884	T	C	SNP	ALS2CR11	ENST00000439140	human	ensembl	74_37	-1	novel	missense	c.2180	p.E727G	0.000	NULL	superfamily_C2_dom	-	no_errors	ALS2CR11	HGNC	ENSG00000155754	tier1	-	-	35	0	0.00	22	7	24.14
ZSCAN20	0	genome.wustl.edu	37	1	33956909	33956909	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	33956909	33956909	C	G	SNP	ZSCAN20	ENST00000361328	human	ensembl	74_37	+1	known	missense	c.1051	p.H351D	1.000	smart_SANT/Myb	pfam_Znf_C2H2,pfam_Tscrpt_reg_SCAN,superfamily_Retrov_capsid_C,smart_Tscrpt_reg_SCAN,smart_SANT/Myb,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Tscrpt_reg_SCAN	-	no_errors	ZSCAN20	HGNC	ENSG00000121903	tier1	-	-	45	0	0.00	17	18	51.43
MUC16	0	genome.wustl.edu	37	19	9085355	9085355	+	Missense_Mutation	SNP	A	A	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	9085355	9085355	A	T	SNP	MUC16	ENST00000397910	human	ensembl	74_37	-1	known	missense	c.6460	p.S2154T	0.019	NULL	pfam_SEA_dom,smart_SEA_dom,pfscan_SEA_dom	-	no_errors	MUC16	HGNC	ENSG00000181143	tier1	-	-	52	0	0.00	29	18	38.30
ANKMY1	0	genome.wustl.edu	37	2	241420409	241420409	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	241420409	241420409	C	G	SNP	ANKMY1	ENST00000272972	human	ensembl	74_37	-1	known	missense	c.2724	p.K908N	0.899	pfam_Znf_MYND,pfscan_Znf_MYND	pfam_Ankyrin_rpt,pfam_MORN,pfam_Znf_MYND,superfamily_Ankyrin_rpt-contain_dom,smart_MORN,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_Znf_MYND	-	no_errors	ANKMY1	HGNC	ENSG00000144504	tier1	-	-	135	0	0.00	135	43	24.02
PRRC2C	0	genome.wustl.edu	37	1	171519345	171519345	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	1	171519345	171519345	A	G	SNP	PRRC2C	ENST00000392078	human	ensembl	74_37	+1	known	missense	c.5093	p.E1698G	1.000	NULL	pfam_BAT2_N	-	no_errors	PRRC2C	HGNC	ENSG00000117523	tier1	-	-	63	0	0.00	36	18	33.33
PIGG	0	genome.wustl.edu	37	4	515060	515060	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	515060	515060	G	T	SNP	PIGG	ENST00000453061	human	ensembl	74_37	+1	known	nonsense	c.1330	p.E444*	1.000	NULL	pfam_Phosphodiest/P_Trfase,superfamily_Alkaline_phosphatase_core	-	no_errors	PIGG	HGNC	ENSG00000174227	tier1	-	-	28	0	0.00	27	4	12.90
MYLK2	0	genome.wustl.edu	37	20	30421644	30421644	+	RNA	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	20	30421644	30421644	G	A	SNP	MYLK2	ENST00000468730	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.003	-	-	-	no_errors	MYLK2	HGNC	ENSG00000101306	tier1	-	-	23	0	0.00	20	12	37.50
ZIC4	0	genome.wustl.edu	37	3	147111638	147111638	+	RNA	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	147111638	147111638	C	T	SNP	ZIC4	ENST00000464502	human	ensembl	74_37	-1	putative	rna	NULL	NULL	0.000	-	-	-	no_errors	ZIC4	HGNC	ENSG00000174963	tier1	-	-	32	0	0.00	8	13	61.90
CLDN4	0	genome.wustl.edu	37	7	73245579	73245579	+	Silent	SNP	G	G	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	73245579	73245579	G	C	SNP	CLDN4	ENST00000340958	human	ensembl	74_37	+1	known	silent	c.48	p.L16	1.000	pfam_PMP22/EMP/MP20/Claudin	pfam_PMP22/EMP/MP20/Claudin,prints_Claudin,prints_Claudin4	-	no_errors	CLDN4	HGNC	ENSG00000189143	tier1	-	-	138	0	0.00	109	23	17.42
NHLRC2	0	genome.wustl.edu	37	10	115661629	115661629	+	Silent	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	10	115661629	115661629	C	T	SNP	NHLRC2	ENST00000369301	human	ensembl	74_37	+1	known	silent	c.1344	p.H448	1.000	NULL	pfam_NHL_repeat,superfamily_Thioredoxin-like_fold,pfscan_NHL_repeat_subgr	-	no_errors	NHLRC2	HGNC	ENSG00000196865	tier1	-	-	35	0	0.00	13	4	23.53
LRFN1	0	genome.wustl.edu	37	19	39799115	39799115	+	Missense_Mutation	SNP	A	A	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	39799115	39799115	A	C	SNP	LRFN1	ENST00000248668	human	ensembl	74_37	-1	known	missense	c.1474	p.C492G	1.000	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Leu-rich_rpt_typical-subtyp,smart_Cys-rich_flank_reg_C,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	LRFN1	HGNC	ENSG00000128011	tier1	-	-	21	0	0.00	16	6	27.27
PCDH10	0	genome.wustl.edu	37	4	134073855	134073855	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	134073855	134073855	G	A	SNP	PCDH10	ENST00000264360	human	ensembl	74_37	+1	known	missense	c.2560	p.G854R	1.000	NULL	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	PCDH10	HGNC	ENSG00000138650	tier1	-	-	39	0	0.00	38	13	25.49
MRPL44	0	genome.wustl.edu	37	2	224831683	224831683	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	2	224831683	224831683	A	G	SNP	MRPL44	ENST00000258383	human	ensembl	74_37	+1	known	missense	c.931	p.R311G	0.682	NULL	superfamily_RNase_III_dom,pfscan_dsRNA-bd_dom	-	no_errors	MRPL44	HGNC	ENSG00000135900	tier1	-	-	38	0	0.00	10	15	60.00
KMT2D	0	genome.wustl.edu	37	12	49446096	49446096	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	12	49446096	49446096	G	A	SNP	KMT2D	ENST00000301067	human	ensembl	74_37	-1	known	missense	c.1370	p.P457L	0.990	NULL	pfam_Znf_PHD-finger,pfam_SET_dom,pfam_FYrich_C,pfam_FYrich_N,superfamily_Znf_FYVE_PHD,superfamily_HMG_box_dom,smart_Znf_PHD,smart_Znf_RING,smart_HMG_box_dom,smart_FYrich_N,smart_FYrich_C,smart_SET_dom,smart_Post-SET_dom,pfscan_SET_dom,pfscan_Post-SET_dom,pfscan_Znf_PHD-finger,pfscan_Znf_RING	-	no_errors	KMT2D	HGNC	ENSG00000167548	tier1	-	-	44	0	0.00	30	8	21.05
ZNF226	0	genome.wustl.edu	37	19	44680347	44680347	+	Missense_Mutation	SNP	A	A	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	19	44680347	44680347	A	T	SNP	ZNF226	ENST00000337433	human	ensembl	74_37	+1	known	missense	c.932	p.E311V	0.017	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF226	HGNC	ENSG00000167380	tier1	-	-	41	0	0.00	26	14	35.00
PARP14	0	genome.wustl.edu	37	3	122437331	122437331	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	122437331	122437331	T	C	SNP	PARP14	ENST00000474629	human	ensembl	74_37	+1	known	missense	c.4333	p.W1445R	0.099	NULL	pfam_Macro_dom,pfam_Poly(ADP-ribose)pol_cat_dom,pfam_WWE-dom,smart_Macro_dom,pfscan_Macro_dom,pfscan_WWE-dom,pfscan_Poly(ADP-ribose)pol_cat_dom	-	no_errors	PARP14	HGNC	ENSG00000173193	tier1	-	-	23	0	0.00	16	10	38.46
PCDHGA10	0	genome.wustl.edu	37	5	140793419	140793419	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	140793419	140793419	G	T	SNP	PCDHGA10	ENST00000398610	human	ensembl	74_37	+1	known	missense	c.677	p.R226L	0.000	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	PCDHGA10	HGNC	ENSG00000253846	tier1	-	-	75	0	0.00	51	21	29.17
OR4A47	0	genome.wustl.edu	37	11	48510756	48510756	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	48510756	48510756	G	A	SNP	OR4A47	ENST00000446524	human	ensembl	74_37	+1	known	missense	c.412	p.V138M	0.011	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4A47	HGNC	ENSG00000237388	tier1	-	-	24	0	0.00	33	4	10.81
EFCAB3	0	genome.wustl.edu	37	17	60493435	60493435	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	60493435	60493435	G	A	SNP	EFCAB3	ENST00000450662	human	ensembl	74_37	+1	known	nonsense	c.1218	p.W406*	1.000	NULL	pfscan_EF_hand_dom	-	no_errors	EFCAB3	HGNC	ENSG00000172421	tier1	-	-	42	0	0.00	44	4	8.33
ERAS	0	genome.wustl.edu	37	X	48688009	48688009	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	48688009	48688009	C	G	SNP	ERAS	ENST00000338270	human	ensembl	74_37	+1	known	missense	c.476	p.A159G	0.003	pfam_Small_GTPase,pfam_Small_GTPase_ARF/SAR,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,tigrfam_Small_GTP-bd_dom	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	-	no_errors	ERAS	HGNC	ENSG00000187682	tier1	-	-	67	0	0.00	50	18	26.47
MMRN2	0	genome.wustl.edu	37	10	88704031	88704031	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	10	88704031	88704031	G	A	SNP	MMRN2	ENST00000372027	human	ensembl	74_37	-1	known	nonsense	c.643	p.Q215*	0.001	NULL	pfam_C1q,pfam_EMI_domain,superfamily_Tumour_necrosis_fac-like_dom,superfamily_tRNA-bd_arm,smart_C1q,prints_C1q,pfscan_C1q,pfscan_EMI_domain	-	no_errors	MMRN2	HGNC	ENSG00000173269	tier1	-	-	58	0	0.00	31	5	13.89
LCORL	0	genome.wustl.edu	37	4	17885560	17885560	+	Missense_Mutation	SNP	T	T	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	4	17885560	17885560	T	G	SNP	LCORL	ENST00000382226	human	ensembl	74_37	-1	known	missense	c.1592	p.E531A	1.000	pfam_HTH_Psq,superfamily_Homeodomain-like,pfscan_HTH_Psq	pfam_HTH_Psq,superfamily_Homeodomain-like,pfscan_HTH_Psq	-	no_errors	LCORL	HGNC	ENSG00000178177	tier1	-	-	47	0	0.00	36	8	18.18
NTRK2	0	genome.wustl.edu	37	9	87563475	87563475	+	Silent	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	87563475	87563475	C	A	SNP	NTRK2	ENST00000277120	human	ensembl	74_37	+1	known	silent	c.1863	p.G621	0.012	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_Ig_I-set,pfam_LRR-contain_N,superfamily_Kinase-like_dom,smart_LRR-contain_N,smart_Cys-rich_flank_reg_C,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,prints_Ser-Thr/Tyr_kinase_cat_dom,prints_Tyr_kinase_NGF_rcpt,prints_Tyr_kin_neurotrophic_rcpt_2	-	no_errors	NTRK2	HGNC	ENSG00000148053	tier1	-	-	73	0	0.00	44	21	32.31
MEX3C	0	genome.wustl.edu	37	18	48723146	48723154	+	In_Frame_Del	DEL	GCCGCCGCG	GCCGCCGCG	-			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	GCCGCCGCG	GCCGCCGCG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	18	48723146	48723154	GCCGCCGCG	-	DEL	MEX3C	ENST00000406189	human	ensembl	74_37	-1	known	in_frame_del	c.545_537	p.AAA182in_frame_del	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.997	NULL	pfam_KH_dom_type_1,smart_KH_dom,smart_Znf_RING,pfscan_Znf_RING,pfscan_KH_dom_type_1	-	no_errors	MEX3C	HGNC	ENSG00000176624	tier1			NA	NA	NA	NA	NA	NA
MED14	0	genome.wustl.edu	37	X	40573854	40573854	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	40573854	40573854	C	T	SNP	MED14	ENST00000324817	human	ensembl	74_37	-1	known	missense	c.457	p.A153T	1.000	pfam_Mediator_Med14	pfam_Mediator_Med14	-	no_errors	MED14	HGNC	ENSG00000180182	tier1	-	-	53	0	0.00	37	11	22.92
OR4C15	0	genome.wustl.edu	37	11	55321796	55321796	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	11	55321796	55321796	C	A	SNP	OR4C15	ENST00000314644	human	ensembl	74_37	+1	known	missense	c.14	p.T5K	0.000	NULL	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4C15	HGNC	ENSG00000181939	tier1	-	-	37	0	0.00	24	15	38.46
ATP9A	0	genome.wustl.edu	37	20	50255956	50255956	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	20	50255956	50255956	G	A	SNP	ATP9A	ENST00000338821	human	ensembl	74_37	-1	known	nonsense	c.1594	p.Q532*	1.000	pfam_HAD-like_dom,superfamily_HAD-like_dom,superfamily_ATPase_P-typ_cyto_domN,tigrfam_ATPase_P-typ_Plipid-transp	pfam_ATPase_P-typ_transduc_dom_A,pfam_HAD-like_dom,superfamily_HAD-like_dom,superfamily_ATPase_P-typ_cyto_domN,prints_Cation_transp_P_typ_ATPase,tigrfam_ATPase_P-typ_Plipid-transp,tigrfam_Cation_transp_P_typ_ATPase	-	no_errors	ATP9A	HGNC	ENSG00000054793	tier1	-	-	53	0	0.00	31	25	44.64
GPR123	0	genome.wustl.edu	37	10	134885552	134885552	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	10	134885552	134885552	T	C	SNP	GPR123	ENST00000607359	human	ensembl	74_37	+1	putative	missense	c.311	p.V104A	0.002	NULL	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like	-	no_errors	GPR123	HGNC	ENSG00000197177	tier1	-	-	150	0	0.00	85	9	9.57
ENSG00000216020	0	genome.wustl.edu	37	3	191693744	191693749	+	RNA	DEL	GTGTGT	GTGTGT	-			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	GTGTGT	GTGTGT					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	191693744	191693749	GTGTGT	-	DEL	ENSG00000216020	ENST00000401201	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.000:0.000:0.000:0.000:0.000:0.000	-	-	-	no_errors	AC026320.1	Clone_based_ensembl_gene	ENSG00000216020	tier1			NA	NA	NA	NA	NA	NA
HTR3E	0	genome.wustl.edu	37	3	183818417	183818417	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	3	183818417	183818417	C	T	SNP	HTR3E	ENST00000335304	human	ensembl	74_37	+1	known	missense	c.257	p.A86V	0.940	pfam_Neur_chan_lig-bd,superfamily_Neur_chan_lig-bd	pfam_Neur_chan_lig-bd,pfam_Neurotrans-gated_channel_TM,superfamily_Neur_chan_lig-bd,superfamily_Neurotrans-gated_channel_TM,prints_Neur_channel	-	no_errors	HTR3E	HGNC	ENSG00000186038	tier1	-	-	93	0	0.00	89	12	11.88
SNAI3	0	genome.wustl.edu	37	16	88747687	88747687	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	16	88747687	88747687	C	T	SNP	SNAI3	ENST00000332281	human	ensembl	74_37	-1	known	missense	c.512	p.R171Q	1.000	smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	SNAI3	HGNC	ENSG00000185669	tier1	-	-	72	0	0.00	49	25	33.78
SPACA1	0	genome.wustl.edu	37	6	88769229	88769229	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	6	88769229	88769229	C	T	SNP	SPACA1	ENST00000237201	human	ensembl	74_37	+1	known	missense	c.533	p.P178L	0.470	NULL	NULL	-	no_errors	SPACA1	HGNC	ENSG00000118434	tier1	-	-	15	0	0.00	12	5	29.41
ENSG00000259455	0	genome.wustl.edu	37	15	23406924	23406924	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	23406924	23406924	G	T	SNP	ENSG00000259455	ENST00000558241	human	ensembl	74_37	-1	novel	missense	c.1912	p.Q638K	0.078	NULL	superfamily_Ribosomal_L7/12_C/ClpS-like,prints_Tropomyosin	-	no_errors	RP11-467N20.5	Clone_based_vega_gene	ENSG00000259455	tier1	-	-	85	0	0.00	68	15	18.07
ZBTB1	0	genome.wustl.edu	37	14	64990324	64990324	+	Missense_Mutation	SNP	T	T	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	14	64990324	64990324	T	G	SNP	ZBTB1	ENST00000394712	human	ensembl	74_37	+1	known	missense	c.2102	p.M701R	1.000	smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_BTB_POZ,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,smart_Znf_C2H2-like,pfscan_BTB/POZ-like,pfscan_Znf_C2H2	-	no_errors	ZBTB1	HGNC	ENSG00000126804	tier1	-	-	18	0	0.00	3	7	70.00
SPRED1	0	genome.wustl.edu	37	15	38641682	38641682	+	Silent	SNP	G	G	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	15	38641682	38641682	G	T	SNP	SPRED1	ENST00000299084	human	ensembl	74_37	+1	known	silent	c.642	p.R214	0.996	NULL	pfam_Sprouty,pfam_WH1/EVH1,smart_WH1/EVH1,pfscan_WH1/EVH1	-	no_errors	SPRED1	HGNC	ENSG00000166068	tier1	-	-	45	0	0.00	16	11	40.74
BRCA2	0	genome.wustl.edu	37	13	32913902	32913902	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	13	32913902	32913902	G	A	SNP	BRCA2	ENST00000380152	human	ensembl	74_37	+1	known	missense	c.5410	p.V1804I	0.000	pirsf_BRCA2	pfam_DNA_recomb/repair_BRCA2_hlx,pfam_BRCA2_repeat,pfam_BRCA2_OB_3,pfam_BRCA2_OB_1,pfam_Tower,superfamily_DNA_recomb/repair_BRCA2_hlx,superfamily_NA-bd_OB-fold,pirsf_BRCA2,pfscan_BRCA2_repeat	-	no_errors	BRCA2	HGNC	ENSG00000139618	tier1	-	-	21	0	0.00	8	9	52.94
LRRC30	0	genome.wustl.edu	37	18	7232042	7232042	+	Nonstop_Mutation	SNP	A	A	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	18	7232042	7232042	A	T	SNP	LRRC30	ENST00000383467	human	ensembl	74_37	+1	known	nonstop	c.906	p.*302C	0.911	NULL	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	LRRC30	HGNC	ENSG00000206422	tier1	-	-	26	0	0.00	4	10	71.43
ALPK2	0	genome.wustl.edu	37	18	56204388	56204402	+	In_Frame_Del	DEL	CAGTTGATGTGTCCT	CAGTTGATGTGTCCT	-			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	CAGTTGATGTGTCCT	CAGTTGATGTGTCCT					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	18	56204388	56204402	CAGTTGATGTGTCCT	-	DEL	ALPK2	ENST00000361673	human	ensembl	74_37	-1	known	in_frame_del	c.3031_3017	p.EDTST1006in_frame_del	0.000:0.000:0.001:0.000:0.000:0.000:0.000:0.000:0.000:0.000:0.000:0.000:0.001:0.001:0.002	NULL	pfam_MHCK_EF2_kinase,pfam_Ig_I-set,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_MHCK_EF2_kinase,pfscan_MHCK_EF2_kinase,pfscan_Ig-like_dom	-	no_errors	ALPK2	HGNC	ENSG00000198796	tier1			NA	NA	NA	NA	NA	NA
DRP2	0	genome.wustl.edu	37	X	100515140	100515140	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	X	100515140	100515140	C	G	SNP	DRP2	ENST00000395209	human	ensembl	74_37	+1	known	missense	c.2731	p.P911A	1.000	pirsf_Dystrophin-related_2	pfam_EF-hand_dom_typ1,pfam_EF-hand_dom_typ2,pfam_Znf_ZZ,pfam_Spectrin_repeat,pfam_WW_dom,superfamily_WW_dom,smart_Spectrin/alpha-actinin,smart_WW_dom,smart_Znf_ZZ,pirsf_Dystrophin-related_2,pfscan_WW_dom,pfscan_Znf_ZZ	-	no_errors	DRP2	HGNC	ENSG00000102385	tier1	-	-	84	0	0.00	75	32	29.91
TBC1D3P1-DHX40P1	0	genome.wustl.edu	37	17	58085530	58085530	+	RNA	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	58085530	58085530	T	C	SNP	TBC1D3P1-DHX40P1	ENST00000407042	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.068	-	-	-	no_errors	TBC1D3P1-DHX40P1	HGNC	ENSG00000267104	tier1	-	-	21	0	0.00	13	4	23.53
CELP	0	genome.wustl.edu	37	9	135962508	135962509	+	RNA	INS	-	-	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	9	135962508	135962509	-	A	INS	CELP	ENST00000411440	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002:0.005	-	-	-	no_errors	CELP	HGNC	ENSG00000170827	tier1			16	0	0.00	6	3	33.33
TP53	0	genome.wustl.edu	37	17	7576897	7576897	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	17	7576897	7576897	G	A	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	nonsense	c.949	p.Q317*	0.012	NULL	pfam_p53_DNA-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_DNA-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	73	0	0.00	32	27	45.76
SNCB	0	genome.wustl.edu	37	5	176048272	176048272	+	Silent	SNP	T	T	C			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	5	176048272	176048272	T	C	SNP	SNCB	ENST00000310112	human	ensembl	74_37	-1	known	silent	c.315	p.E105	0.990	pfam_Synuclein,prints_Synuclein_beta	pfam_Synuclein,prints_Synuclein,prints_Synuclein_beta	-	no_errors	SNCB	HGNC	ENSG00000074317	tier1	-	-	66	0	0.00	55	11	16.67
NOS3	0	genome.wustl.edu	37	7	150696416	150696416	+	Silent	SNP	G	G	A			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	7	150696416	150696416	G	A	SNP	NOS3	ENST00000297494	human	ensembl	74_37	+1	known	silent	c.1095	p.R365	0.997	pfam_NO_synthase_oxygenase_dom,superfamily_NO_synthase_oxygenase_dom,pirsf_NOS_euk	pfam_NO_synthase_oxygenase_dom,pfam_FAD-binding_1,pfam_Flavodoxin/NO_synth,pfam_OxRdtase_FAD/NAD-bd,superfamily_NO_synthase_oxygenase_dom,superfamily_Riboflavin_synthase-like_b-brl,pirsf_NOS_euk,pfscan_Flavodoxin/NO_synth,prints_Flavoprot_Pyr_Nucl_cyt_Rdtase,prints_Flavdoxin	-	no_errors	NOS3	HGNC	ENSG00000164867	tier1	-	-	21	0	0.00	17	12	41.38
ZNF831	0	genome.wustl.edu	37	20	57829403	57829403	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3K7-01A-11D-A21Q-09	TCGA-IS-A3K7-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	afee5b10-3dff-4e50-9575-bc9fe20c5dea	71896be3-fce7-4266-b6d8-3e20e38337fd	20	57829403	57829403	C	T	SNP	ZNF831	ENST00000371030	human	ensembl	74_37	+1	novel	missense	c.4639	p.P1547S	0.000	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF831	HGNC	ENSG00000124203	tier1	-	-	25	0	0.00	16	4	20.00
