Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SLC2A7	155184	broad.mit.edu	37	1	9086388	9086388	+	Missense_Mutation	SNP	G	G	T	rs150973958	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:9086388G>T	uc009vmo.1	-	1	17	c.17C>A	c.(16-18)GCG>GAG	p.A6E		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	6	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		AGGGGTTCCCGCCTCTTTGTT	0.582		NA											7	24					1.07e-07	1.15e-07	1	0
VPS13D	55187	broad.mit.edu	37	1	12423152	12423152	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:12423152A>T	uc001atv.2	+	52	10438	c.10297A>T	c.(10297-10299)ATT>TTT	p.I3433F	VPS13D_uc001atw.2_Missense_Mutation_p.I3408F|VPS13D_uc001atx.2_Missense_Mutation_p.I2620F	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3432					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CGAAGGTTACATTTCCACCCT	0.383		NA											82	204					0	0	0	0
KIAA0467	23334	broad.mit.edu	37	1	43908207	43908207	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:43908207A>T	uc001cjk.1	+	43	5834	c.5372A>T	c.(5371-5373)CAT>CTT	p.H1791L		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2690						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCACGAGCCCATCTCATCTTC	0.587		NA											53	114					0	0	0	0
BEND5	79656	broad.mit.edu	37	1	49202065	49202065	+	Silent	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:49202065G>C	uc001crx.3	-	5	998	c.954C>G	c.(952-954)ACC>ACG	p.T318T	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Silent_p.T149T	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	318	BEN.									skin(1)	1						AATCTCCTTGGGTTACTTGTA	0.468		NA											6	234					0	0	0	0
DIO1	1733	broad.mit.edu	37	1	54370406	54370406	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:54370406G>A	uc010onx.1	+	3	428	c.405G>A	c.(403-405)CAG>CAA	p.Q135Q	DIO1_uc010onw.1_Silent_p.Q71Q|DIO1_uc009vzl.2_Intron|DIO1_uc001cwb.2_Intron|DIO1_uc010ony.1_Silent_p.Q135Q|DIO1_uc001cwd.2_RNA|DIO1_uc001cwe.2_Intron|DIO1_uc001cwf.2_RNA|DIO1_uc001cwg.2_RNA	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	135					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0						AATTTGACCAGTTCAAGAGGC	0.393		NA											102	209					0	0	0	0
LPHN2	23266	broad.mit.edu	37	1	82436053	82436053	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:82436053C>A	uc001dit.3	+	15	2919	c.2738C>A	c.(2737-2739)GCT>GAT	p.A913D	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.A913D|LPHN2_uc001div.2_Missense_Mutation_p.A913D|LPHN2_uc009wcd.2_Missense_Mutation_p.A913D|LPHN2_uc001diw.2_Missense_Mutation_p.A497D|LPHN2_uc009wce.1_5'UTR	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	926	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCAGCTTTTGCTTGGATGTGC	0.358		NA											67	230					6.53e-41	7.42e-41	1	0
ARHGAP29	9411	broad.mit.edu	37	1	94645394	94645394	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:94645394C>G	uc001dqj.3	-	20	2736	c.2367G>C	c.(2365-2367)TGG>TGC	p.W789C	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.W355C	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	789	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ACATATTTGGCCATTTTTTGT	0.308		NA											30	123					0	0	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94697030	94697030	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:94697030C>T	uc001dqj.3	-	2	507	c.138G>A	c.(136-138)AAG>AAA	p.K46K	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.K46K	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	46					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCACCAACTCCTTGATGTAAT	0.388		NA											58	107					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109795731	109795731	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:109795731C>T	uc001dxa.3	+	1	3091	c.3030C>T	c.(3028-3030)CAC>CAT	p.H1010H		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1010	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTACAGTCCACGTCCGCCTCC	0.577		NA											22	112					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118640342	118640342	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:118640342A>T	uc001ehk.2	-	7	1030	c.962T>A	c.(961-963)ATG>AAG	p.M321K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	321						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGCTTTGACCATGTACTCAAG	0.408		NA											33	75					0	0	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145290477	145290477	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:145290477C>G	uc001emo.2	+	5	1053	c.683C>G	c.(682-684)TCA>TGA	p.S228*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001end.3_5'Flank|NBPF10_uc001emq.1_5'Flank	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	Error:Variant_position_missing_in_Q7Z3S9_after_alignment					cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GAAAAGGAATCATACTGCTAA	0.368		NA											13	447					0	0	0	0
BCL9	607	broad.mit.edu	37	1	147086390	147086390	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:147086390G>A	uc001epq.2	+	6	1275	c.535G>A	c.(535-537)GTG>ATG	p.V179M	BCL9_uc010ozr.1_Missense_Mutation_p.V105M	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	179					Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGTGGTGTACGTGTTTTCTAC	0.507		NA	T	IGH@|IGL@	B-ALL								13	52					0	0	0	0
ECM1	1893	broad.mit.edu	37	1	150483454	150483454	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:150483454G>A	uc001eus.2	+	6	687	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	ECM1_uc010pce.1_Missense_Mutation_p.R92Q|ECM1_uc010pcf.1_Missense_Mutation_p.R85Q|ECM1_uc001eut.2_Missense_Mutation_p.R163Q|ECM1_uc001euu.2_Missense_Mutation_p.R192Q|ECM1_uc001euv.2_Missense_Mutation_p.R190Q|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	163	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGGGGCCACCGGCTGGATGGC	0.607		NA											125	189					0	0	0	0
SETDB1	9869	broad.mit.edu	37	1	150935566	150935566	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:150935566A>G	uc001evu.2	+	19	3598	c.3408A>G	c.(3406-3408)ATA>ATG	p.I1136M	SETDB1_uc001evv.2_Missense_Mutation_p.I1136M|SETDB1_uc009wmg.1_Missense_Mutation_p.I1136M	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1136	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCAGACCATATCCTCTGGCT	0.498		NA											26	82					0	0	0	0
DCST2	127579	broad.mit.edu	37	1	155004226	155004226	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:155004226C>T	uc001fgm.2	-	4	643	c.563G>A	c.(562-564)TGG>TAG	p.W188*	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	188	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GAGCCACTGCCACACATTCCG	0.582		NA											6	19					0	0	0	0
OR10X1	128367	broad.mit.edu	37	1	158549182	158549182	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:158549182A>G	uc010pin.1	-	1	508	c.508T>C	c.(508-510)TTT>CTT	p.F170L		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGAGAGATAAAGAAGCCTGCA	0.468		NA											26	64					0	0	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815800	179815800	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:179815800C>T	uc001gnk.2	-	6	1207	c.819G>A	c.(817-819)CTG>CTA	p.L273L	TOR1AIP2_uc001gnl.2_Silent_p.L273L	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	273						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						CTCTCTGCCACAGGAAGGAAC	0.522		NA											28	139					0	0	0	0
XPR1	9213	broad.mit.edu	37	1	180805685	180805685	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:180805685A>G	uc001goi.2	+	11	1526	c.1334A>G	c.(1333-1335)TAT>TGT	p.Y445C	XPR1_uc009wxm.2_Missense_Mutation_p.Y445C|XPR1_uc009wxn.2_Intron	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	445	Cytoplasmic (Potential).|EXS.					integral to plasma membrane	G-protein coupled receptor activity				0						AAATATACATATGGTGTGCGG	0.403		NA											35	91					0	0	0	0
ZBTB41	360023	broad.mit.edu	37	1	197145781	197145781	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:197145781G>A	uc001gtx.1	-	7	1861	c.1792C>T	c.(1792-1794)CAT>TAT	p.H598Y	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TTATCATCATGATGTACTCGT	0.299		NA											38	127					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240493929	240493929	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:240493929G>A	uc010pyd.1	+	11	4689	c.4464G>A	c.(4462-4464)ATG>ATA	p.M1488I	FMN2_uc010pye.1_Missense_Mutation_p.M1492I|FMN2_uc010pyf.1_Missense_Mutation_p.M134I|FMN2_uc010pyg.1_Missense_Mutation_p.M84I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1488	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGGGGTTATGCAGGTTCTAG	0.388		NA											27	106					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243716166	243716166	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:243716166C>A	uc001iab.1	-	10	1109	c.1028G>T	c.(1027-1029)AGG>ATG	p.R343M	AKT3_uc001hzz.1_Missense_Mutation_p.R343M	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	343	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAAAGGTAACCTCCCACACAT	0.383		NA											49	275					1.11e-26	1.25e-26	1	0
KIF5B	3799	broad.mit.edu	37	10	32326241	32326241	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:32326241G>C	uc001iwe.3	-	8	1122	c.652C>G	c.(652-654)CAA>GAA	p.Q218E		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	218	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				TGTTCCGTTTGTGTGTTCTCT	0.313		NA											10	120					0	0	0	0
PTEN	5728	broad.mit.edu	37	10	89711893	89711893	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:89711893C>T	uc001kfb.2	+	7	1542	c.511C>T	c.(511-513)CAG>TAG	p.Q171*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	171	Phosphatase tensin-type.			Q->A,E: 75% reduction in phosphatase activity towards PtdIns(3,4,5)P3.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Q171*(9)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.Y27_N212>Y(2)|p.Q171P(2)|p.Y27fs*1(2)|p.Q171E(2)|p.V166fs*10(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.Q171H(1)|p.S170fs*8(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATTCCCAGTCAGAGGCGCTA	0.353		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			70	105					0	0	0	0
TIAL1	7073	broad.mit.edu	37	10	121336662	121336662	+	Missense_Mutation	SNP	G	G	A	rs148932828	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:121336662G>A	uc001lei.1	-	10	1355	c.791C>T	c.(790-792)ACG>ATG	p.T264M	TIAL1_uc001leh.1_Missense_Mutation_p.T242M|TIAL1_uc001lej.1_Missense_Mutation_p.T281M|TIAL1_uc001lek.1_Missense_Mutation_p.T141M|TIAL1_uc009xzi.1_Missense_Mutation_p.T133M|TIAL1_uc010qtb.1_Missense_Mutation_p.T141M	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	264	RRM 3.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		TCCTTCAATCGTAGTACCGTT	0.348		NA											36	34					0	0	0	0
LRRC27	80313	broad.mit.edu	37	10	134188714	134188714	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:134188714G>A	uc010quw.1	+	11	1756	c.1561G>A	c.(1561-1563)GGA>AGA	p.G521R	LRRC27_uc001llg.2_RNA|LRRC27_uc001lli.2_Missense_Mutation_p.G521R|LRRC27_uc001llj.2_Missense_Mutation_p.G459R	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a	521										ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CACAAAATATGGAGAATCAGG	0.522		NA											20	25					0	0	0	0
PKP3	11187	broad.mit.edu	37	11	404005	404005	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:404005C>T	uc001lpc.2	+	11	2216	c.2140C>T	c.(2140-2142)CCA>TCA	p.P714S		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	714	ARM 8.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAAGTCGCCCCCAGCCGAGGT	0.627		NA											24	70					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1155707	1155707	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:1155707C>T	uc009ycr.1	+	5	521	c.395C>T	c.(394-396)ACG>ATG	p.T132M		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCGGCCCCCACGCTGAGCAGG	0.632		NA											13	28					0	0	0	0
OR51B2	79345	broad.mit.edu	37	11	5344959	5344959	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:5344959A>C	uc001mao.1	-	1	624	c.569T>G	c.(568-570)ATA>AGA	p.I190R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTGAAAGTTATGTCAGCACA	0.353		NA											25	48					0	0	0	0
OR56A3	390083	broad.mit.edu	37	11	5969347	5969347	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:5969347C>T	uc010qzt.1	+	1	771	c.771C>T	c.(769-771)ACC>ACT	p.T257T		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTCAGCACCATCCTTCTGG	0.527		NA											65	227					0	0	0	0
PAX6	5080	broad.mit.edu	37	11	31816281	31816281	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:31816281G>A	uc001mtd.3	-	7	1469	c.579C>T	c.(577-579)AAC>AAT	p.N193N	PAX6_uc001mte.3_Silent_p.N193N|PAX6_uc001mtg.3_Silent_p.N207N|PAX6_uc001mtf.3_Silent_p.N193N|PAX6_uc001mth.3_Silent_p.N193N|PAX6_uc009yjr.2_Silent_p.N193N	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	193	Gln/Gly-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					AATCTTCTCCGTTGGAACTGA	0.453		NA							Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				34	101					0	0	0	0
OR4C46	119749	broad.mit.edu	37	11	51515476	51515476	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:51515476C>T	uc010ric.1	+	1	195	c.195C>T	c.(193-195)TCC>TCT	p.S65S		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTATCTCTCCTTTATTGATG	0.478		NA											87	287					0	0	0	0
RTN4RL2	349667	broad.mit.edu	37	11	57243919	57243919	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:57243919C>G	uc010rjt.1	+	3	798	c.798C>G	c.(796-798)GAC>GAG	p.D266E		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	266	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity				0						GGGCGTGCGACTGCCGCGCGC	0.741		NA											4	17					0	0	0	0
KDM2A	22992	broad.mit.edu	37	11	66985219	66985219	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:66985219C>T	uc001ojw.2	+	9	1569	c.705C>T	c.(703-705)CCC>CCT	p.P235P	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Intron	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	235	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						GGCTCATCCCCCCTACAGCCC	0.483		NA											5	39					0	0	0	0
ANO1	55107	broad.mit.edu	37	11	70028647	70028647	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:70028647C>T	uc001opj.2	+	24	2748	c.2443C>T	c.(2443-2445)CTG>TTG	p.L815L	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Silent_p.L524L|ANO1_uc010rql.1_5'UTR	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	815	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CATCCCGCGCCTGGTGTACCT	0.617		NA											23	322					0	0	0	0
STARD10	10809	broad.mit.edu	37	11	72468875	72468875	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:72468875G>A	uc001osy.2	-	5	805	c.514C>T	c.(514-516)CTC>TTC	p.L172F	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.L172F|STARD10_uc001ota.2_Missense_Mutation_p.L126F|STARD10_uc001otb.2_Missense_Mutation_p.L172F	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	172	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			CTCTGGATGAGGTAGCCCGTC	0.612		NA											35	47					0	0	0	0
KDM4DL	390245	broad.mit.edu	37	11	94759470	94759470	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:94759470T>C	uc010ruf.1	+	1	1049	c.749T>C	c.(748-750)GTT>GCT	p.V250A		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	250	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TCGCCTACAGTTCTCAAGGAA	0.567		NA											16	19					0	0	0	0
SLC6A12	6539	broad.mit.edu	37	12	301770	301770	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:301770G>A	uc001qhz.2	-	16	2118	c.1575C>T	c.(1573-1575)TAC>TAT	p.Y525Y	SLC6A12_uc001qhx.2_Silent_p.Y182Y|SLC6A12_uc001qhy.2_Silent_p.Y81Y|SLC6A12_uc001qia.2_Silent_p.Y525Y|SLC6A12_uc001qib.2_Silent_p.Y525Y|SLC6A12_uc009zdh.1_Silent_p.Y525Y	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	525					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			AGACGTTGTTGTACTTGAGGG	0.572		NA											41	110					0	0	0	0
CHD4	1108	broad.mit.edu	37	12	6690898	6690898	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:6690898G>A	uc001qpo.2	-	31	4762	c.4598C>T	c.(4597-4599)CCA>CTA	p.P1533L	CHD4_uc001qpn.2_Missense_Mutation_p.P1526L|CHD4_uc001qpp.2_Missense_Mutation_p.P1558L|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1533					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGGTGACCCTGGCTGGGACAT	0.562		NA											66	154					0	0	0	0
FAM90A1	55138	broad.mit.edu	37	12	8376719	8376719	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:8376719G>C	uc001qui.2	-	5	775	c.216C>G	c.(214-216)AAC>AAG	p.N72K	FAM90A1_uc001quh.2_Missense_Mutation_p.N72K	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	72							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TTTCCCCAAAGTTCGGTGGAA	0.547		NA											79	164					0	0	0	0
PRB1	5542	broad.mit.edu	37	12	11506685	11506685	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:11506685G>C	uc001qzw.1	-	3	389	c.352C>G	c.(352-354)CCA>GCA	p.P118A	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	179	7.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGTCCTTGTGGCTTTCCTGGA	0.612		NA											55	762					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49420409	49420409	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:49420409G>A	uc001rta.3	-	48	15340	c.15340C>T	c.(15340-15342)CAT>TAT	p.H5114Y		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5114	RING-type 4; degenerate.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAAGCAAAATGGTAGACATTG	0.557		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			35	90					0	0	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037938	50037938	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:50037938G>A	uc001rur.1	+	25	2643	c.2579G>A	c.(2578-2580)CGG>CAG	p.R860Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001ruq.1_Missense_Mutation_p.R847Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R802Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	860					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GAGAGGCGGCGGCGGACACTC	0.607		NA									OREG0021798	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	62					0	0	0	0
GNPTAB	79158	broad.mit.edu	37	12	102151077	102151077	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:102151077A>G	uc001tit.2	-	18	3526	c.3347T>C	c.(3346-3348)ATG>ACG	p.M1116T		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	1116					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						TTCTTCTCCCATGATTTCAAA	0.284		NA											7	45					0	0	0	0
DRAM1	55332	broad.mit.edu	37	12	102295157	102295157	+	Silent	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:102295157T>C	uc001tix.2	+	3	751	c.288T>C	c.(286-288)TCT>TCC	p.S96S	DRAM1_uc010svv.1_Silent_p.S96S	NM_018370	NP_060840	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	96	Helical; (Potential).				apoptosis|autophagy	integral to membrane|lysosomal membrane				ovary(1)	1						ACTTGGTGTCTTTAGTGCTTG	0.408		NA											23	85					0	0	0	0
RAD9B	144715	broad.mit.edu	37	12	110968353	110968353	+	Silent	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:110968353A>G	uc001trf.3	+	11	1287	c.1149A>G	c.(1147-1149)GCA>GCG	p.A383A	RAD9B_uc001trg.3_Silent_p.A383A|RAD9B_uc010sya.1_Intron|RAD9B_uc001tre.3_Silent_p.A311A|RAD9B_uc001trd.3_Silent_p.A225A	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	380					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						TCTTTGGAGCAGTTTCTTCTG	0.433		NA											36	127					0	0	0	0
SFRS8	6433	broad.mit.edu	37	12	132237706	132237706	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:132237706C>T	uc001uja.1	+	8	1260	c.1120C>T	c.(1120-1122)CCG>TCG	p.P374S	SFRS8_uc010tbn.1_Missense_Mutation_p.P374S|SFRS8_uc001ujb.1_Missense_Mutation_p.P167S|SFRS8_uc001uiz.1_Missense_Mutation_p.P248S	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	374					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		CTACATGCTACCGGACGGCAC	0.612		NA											56	119					0	0	0	0
ZMYM2	7750	broad.mit.edu	37	13	20656229	20656229	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:20656229A>G	uc001umr.2	+	23	3825	c.3527A>G	c.(3526-3528)AAT>AGT	p.N1176S	ZMYM2_uc001ums.2_Missense_Mutation_p.N1176S|ZMYM2_uc001umt.2_Missense_Mutation_p.N1176S|ZMYM2_uc001umv.2_Missense_Mutation_p.N556S|ZMYM2_uc001umw.2_Missense_Mutation_p.N629S	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAGAATTGAATAAAATACTG	0.328		NA											16	15					0	0	0	0
KATNAL1	84056	broad.mit.edu	37	13	30801627	30801627	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:30801627C>T	uc001uss.2	-	9	1170	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	KATNAL1_uc001ust.2_Missense_Mutation_p.A357T	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	357						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		AAATTAGTAGCAGCCAATACC	0.378		NA											20	43					0	0	0	0
KLHL1	57626	broad.mit.edu	37	13	70535475	70535475	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:70535475T>A	uc001vip.2	-	3	1576	c.782A>T	c.(781-783)AAT>ATT	p.N261I	KLHL1_uc010thm.1_Missense_Mutation_p.N200I	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	261	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCAGAGAGCATTGGGGTCTAT	0.383		NA											44	55					0	0	0	0
SUPT16H	11198	broad.mit.edu	37	14	21831284	21831284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:21831284G>A	uc001wao.2	-	13	1759	c.1420C>T	c.(1420-1422)CGA>TGA	p.R474*		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	474	Potential.				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGTGCTCTTCGCTTCTCTTCT	0.398		NA											58	171					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23884668	23884668	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:23884668G>A	uc001wjx.2	-	36	5311	c.5205C>T	c.(5203-5205)TCC>TCT	p.S1735S		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1735	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTGGAGCTGGGACAGGTCAG	0.557		NA											46	125					0	0	0	0
GPR137C	283554	broad.mit.edu	37	14	53098999	53098999	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:53098999A>C	uc001wzu.3	+	4	839	c.839A>C	c.(838-840)AAT>ACT	p.N280T	GPR137C_uc001wzt.3_Missense_Mutation_p.N296T	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	280	Extracellular (Potential).					integral to membrane					0	Breast(41;0.0716)					AGTCCATTTAATTATGGCTGG	0.388		NA											30	69					0	0	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68008608	68008608	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:68008608G>A	uc001xjl.1	+	2	166	c.24G>A	c.(22-24)GCG>GCA	p.A8A		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	8						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGGTGGAGGCGCCGGCCAGCG	0.537		NA											3	10					0	0	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68249583	68249583	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:68249583G>A	uc001xka.2	-	21	4425	c.4286C>T	c.(4285-4287)GCC>GTC	p.A1429V	ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.3_Missense_Mutation_p.A1429V	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1429					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GAGCTGAAGGGCCCGGGACCA	0.532		NA											80	226					0	0	0	0
C14orf169	79697	broad.mit.edu	37	14	73957815	73957815	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:73957815C>T	uc001xok.1	+	1	172	c.93C>T	c.(91-93)GCC>GCT	p.A31A	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	31					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		CGGTCCTGGCCCTGCCCTTGA	0.677		NA											15	27					0	0	0	0
PNMA1	9240	broad.mit.edu	37	14	74179621	74179621	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:74179621T>C	uc001xor.1	-	1	1508	c.722A>G	c.(721-723)GAG>GGG	p.E241G		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		cctagagctctcaacgctccc	0		NA											41	115					0	0	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91338426	91338426	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:91338426C>T	uc001xys.2	-	17	2616	c.2401G>A	c.(2401-2403)GTA>ATA	p.V801I	RPS6KA5_uc010twi.1_Missense_Mutation_p.V722I	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	801				VA -> ELRHGRSDQ (in Ref. 3; AAC69577).	axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GCCTAAGCTACTGAGTCCGAG	0.483		NA											54	128					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24921512	24921512	+	Silent	SNP	G	G	A	rs35737140	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:24921512G>A	uc001ywo.2	+	1	972	c.498G>A	c.(496-498)CCG>CCA	p.P166P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	166					cell differentiation|multicellular organismal development|spermatogenesis			p.P166P(1)		ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ATGAGGATCCGGTGCAGATCG	0.627		NA											3	74					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24922597	24922597	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:24922597C>T	uc001ywo.2	+	1	2057	c.1583C>T	c.(1582-1584)TCC>TTC	p.S528F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	528	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCCTCTTTCCTTCCTGACT	0.532		NA											99	293					0	0	0	0
MNS1	55329	broad.mit.edu	37	15	56748614	56748614	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:56748614T>C	uc002adr.2	-	3	496	c.331A>G	c.(331-333)AGG>GGG	p.R111G	MNS1_uc010bfo.2_5'UTR	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	111	Potential.|Glu-rich.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		ACTTGTTGCCTCATCTTTTCG	0.333		NA											3	95					0	0	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1812698	1812698	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:1812698G>A	uc002cmk.2	+	15	1810	c.1690G>A	c.(1690-1692)GTC>ATC	p.V564I	MAPK8IP3_uc002cml.2_Missense_Mutation_p.V558I|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.V565I	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	564					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GCACCCATCCGTCCAGGAGAA	0.662		NA											81	165					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3786099	3786099	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:3786099G>C	uc002cvv.2	-	28	4870	c.4666C>G	c.(4666-4668)CTA>GTA	p.L1556V	CREBBP_uc002cvw.2_Missense_Mutation_p.L1518V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1556	Poly-Glu.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCTTGTTCTAGTTCCTTAATG	0.478		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				50	107					0	0	0	0
ANKS3	124401	broad.mit.edu	37	16	4747373	4747373	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:4747373C>T	uc002cxj.1	-	16	2150	c.1855G>A	c.(1855-1857)GAG>AAG	p.E619K	ANKS3_uc010uxr.1_Missense_Mutation_p.E142K|ANKS3_uc002cxh.1_RNA|ANKS3_uc002cxi.1_Missense_Mutation_p.E546K|ANKS3_uc002cxk.2_Missense_Mutation_p.E490K|ANKS3_uc002cxl.2_Missense_Mutation_p.E446K|ANKS3_uc010uxs.1_Missense_Mutation_p.E546K	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	619											0						CCCGAGAGCTCGGGGAGGCTC	0.657		NA											48	119					0	0	0	0
SEPT12	124404	broad.mit.edu	37	16	4833975	4833975	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:4833975G>A	uc002cxq.2	-	5	610	c.469C>T	c.(469-471)CGG>TGG	p.R157W	SEPT12_uc002cxr.2_Intron|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	157					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CAGTGCACCCGGGTGTCTGGG	0.637		NA											49	133					0	0	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24971270	24971270	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:24971270T>G	uc002dnb.2	-	8	697	c.604A>C	c.(604-606)ATG>CTG	p.M202L	ARHGAP17_uc002dna.2_5'Flank|ARHGAP17_uc002dnc.2_Missense_Mutation_p.M202L|ARHGAP17_uc010vcf.1_Missense_Mutation_p.M23L|ARHGAP17_uc002dnf.2_Missense_Mutation_p.M110L|ARHGAP17_uc002dng.1_Missense_Mutation_p.M202L	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	202	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TCTTTGGCCATAAAGTTGTAC	0.363		NA											35	106					0	0	0	0
E2F4	1874	broad.mit.edu	37	16	67228755	67228755	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:67228755C>T	uc002erz.2	+	6	743	c.680C>T	c.(679-681)CCT>CTT	p.P227L		NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	227					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		ACACCTCCACCTCTGCCCAAG	0.597		NA											48	95					0	0	0	0
CDH1	999	broad.mit.edu	37	16	68853291	68853291	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:68853291C>A	uc002ewg.1	+	11	1798	c.1674C>A	c.(1672-1674)AAC>AAA	p.N558K	CDH1_uc010vlj.1_Intron|CDH1_uc010cfg.1_Missense_Mutation_p.N497K	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	558	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACGTGAAGAACAGCACGTACA	0.537		NA	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				4	101					0.00909568	0.00931271	1	0
ZNF778	197320	broad.mit.edu	37	16	89293174	89293174	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:89293174C>T	uc002fmv.2	+	6	733	c.394C>T	c.(394-396)CTC>TTC	p.L132F	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.L90F|ZNF778_uc010vpg.1_5'UTR	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	132	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		ACACTCAGGCCTCAGCACACA	0.463		NA											15	37					0	0	0	0
NUP88	4927	broad.mit.edu	37	17	5312067	5312067	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:5312067G>A	uc002gbo.1	-	5	869	c.843C>T	c.(841-843)ATC>ATT	p.I281I	NUP88_uc010vsx.1_Silent_p.I281I|NUP88_uc010cle.1_Silent_p.I280I|NUP88_uc010vsy.1_Silent_p.I281I	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	281					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						GTAACAGACTGATGTATGTCA	0.438		NA											86	64					0	0	0	0
PHF23	79142	broad.mit.edu	37	17	7139299	7139299	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7139299G>A	uc002gfa.2	-	4	1174	c.947C>T	c.(946-948)TCC>TTC	p.S316F	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Missense_Mutation_p.S249F|PHF23_uc010cma.2_Missense_Mutation_p.S186F	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	316							zinc ion binding				0						GCCTTCACTGGAGCTGGCATC	0.587		NA											416	274					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577507	7577507	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7577507T>A	uc002gim.2	-	7	968	c.774A>T	c.(772-774)GAA>GAT	p.E258D	TP53_uc002gig.1_Missense_Mutation_p.E258D|TP53_uc002gih.2_Missense_Mutation_p.E258D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E126D|TP53_uc010cng.1_Missense_Mutation_p.E126D|TP53_uc002gii.1_Missense_Mutation_p.E126D|TP53_uc010cnh.1_Missense_Mutation_p.E258D|TP53_uc010cni.1_Missense_Mutation_p.E258D|TP53_uc002gij.2_Missense_Mutation_p.E258D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E165D|TP53_uc002gio.2_Missense_Mutation_p.E126D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	258	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> Q (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E258K(37)|p.E258*(12)|p.E258Q(8)|p.E258D(8)|p.0?(7)|p.E258G(7)|p.E258V(5)|p.E258A(5)|p.D259fs*5(1)|p.?(1)|p.E258fs*85(1)|p.E258>XX(1)|p.E258fs*71(1)|p.D259fs*86(1)|p.E258fs*2(1)|p.E258_S260delEDS(1)|p.E258del(1)|p.E258L(1)|p.E258fs*87(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCTGGAGTCTTCCAGTGTGA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	31					0	0	0	0
CNTROB	116840	broad.mit.edu	37	17	7836476	7836476	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7836476C>T	uc002gjq.2	+	2	998	c.79C>T	c.(79-81)CTC>TTC	p.L27F	TRAPPC1_uc002gjo.1_5'Flank|CNTROB_uc002gjp.2_Missense_Mutation_p.L27F|CNTROB_uc002gjr.2_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	27					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				ACCCCCTGGGCTCAACCAAGT	0.597		NA											163	127					0	0	0	0
STX8	9482	broad.mit.edu	37	17	9395196	9395196	+	Missense_Mutation	SNP	C	C	T	rs143935601		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:9395196C>T	uc002glx.2	-	6	641	c.491G>A	c.(490-492)CGC>CAC	p.R164H		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8	164	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						TTGTTTTTGGCGACTTATGAT	0.363		NA											109	117					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10356164	10356164	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:10356164G>A	uc002gmn.2	-	25	3308	c.3197C>T	c.(3196-3198)GCC>GTC	p.A1066V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1066	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGATTCTTGGGCCAATTTTAG	0.363		NA											143	145					0	0	0	0
MPP2	4355	broad.mit.edu	37	17	41958711	41958711	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:41958711G>A	uc010wip.1	-	8	1012	c.955C>T	c.(955-957)CAT>TAT	p.H319Y	MPP2_uc002ien.1_Missense_Mutation_p.H291Y|MPP2_uc010wim.1_Missense_Mutation_p.H263Y|MPP2_uc002ieo.1_Missense_Mutation_p.H274Y|MPP2_uc010win.1_Missense_Mutation_p.H135Y|MPP2_uc010wio.1_Missense_Mutation_p.H263Y	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	298	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CCTTCGACATGGCATGCCTAA	0.597		NA									OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	111	59					0	0	0	0
FTSJ3	117246	broad.mit.edu	37	17	61903471	61903471	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:61903471G>A	uc002jbz.2	-	4	323	c.245C>T	c.(244-246)CCT>CTT	p.P82L	FTSJ3_uc002jca.2_Missense_Mutation_p.P82L|PSMC5_uc002jcb.2_5'Flank|PSMC5_uc010ddy.2_5'Flank|PSMC5_uc010ddz.2_5'Flank|PSMC5_uc002jcc.2_5'Flank|PSMC5_uc002jcd.2_5'Flank	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	82					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						ATTGGGGAGAGGCTTGATTGG	0.468		NA											130	98					0	0	0	0
METRNL	284207	broad.mit.edu	37	17	81043036	81043036	+	Silent	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:81043036A>G	uc002kgh.2	+	2	518	c.393A>G	c.(391-393)GTA>GTG	p.V131V	METRNL_uc002kgi.2_Silent_p.V49V	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	131						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			GACTGCTGGTACCAGACGGGG	0.632		NA											72	42					0	0	0	0
CDH2	1000	broad.mit.edu	37	18	25585828	25585828	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:25585828C>G	uc002kwg.2	-	6	1291	c.832G>C	c.(832-834)GAG>CAG	p.E278Q	CDH2_uc010xbn.1_Missense_Mutation_p.E247Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	278	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTTGATCCCTCAGGAACTGTC	0.388		NA											48	116					0	0	0	0
PIGN	23556	broad.mit.edu	37	18	59777191	59777191	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:59777191G>A	uc002lii.3	-	18	1898	c.1450C>T	c.(1450-1452)CTG>TTG	p.L484L	PIGN_uc002lij.3_Silent_p.L484L	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	484	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				CTACAAGGCAGGAGATGGCTT	0.343		NA											3	66					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64239355	64239355	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:64239355C>G	uc002lkc.1	-	2	225	c.87G>C	c.(85-87)AAG>AAC	p.K29N	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.K29N|CDH19_uc002lkd.2_Missense_Mutation_p.K29N	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	29					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GCTTGACTTTCTTTGTTTGAG	0.428		NA											19	39					0	0	0	0
NETO1	81832	broad.mit.edu	37	18	70423379	70423379	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:70423379G>T	uc002lkw.2	-	8	1156	c.872C>A	c.(871-873)CCT>CAT	p.P291H	NETO1_uc002lkx.1_Missense_Mutation_p.P290H|NETO1_uc002lky.1_Missense_Mutation_p.P291H	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	291	LDL-receptor class A.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GCCTTCACAAGGAGCTAAAAA	0.333		NA											29	50					4.88e-14	5.41e-14	1	0
ZNF236	7776	broad.mit.edu	37	18	74631933	74631933	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:74631933C>T	uc002lmi.2	+	20	3668	c.3470C>T	c.(3469-3471)GCG>GTG	p.A1157V	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1157					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GACAAGCAGGCGGAGCTGCAG	0.627		NA											13	24					0	0	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600302	3600302	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:3600302C>T	uc002lyg.1	-	2	545	c.331G>A	c.(331-333)GTC>ATC	p.V111I	TBXA2R_uc002lye.1_Missense_Mutation_p.V111I	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	111	Helical; Name=3; (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	AAGATCATGACGACGCCCATG	0.692		NA											13	23					0	0	0	0
ACSBG2	81616	broad.mit.edu	37	19	6187796	6187796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:6187796C>T	uc002mef.1	+	13	2094	c.1867C>T	c.(1867-1869)CAG>TAG	p.Q623*	ACSBG2_uc002mee.1_Nonsense_Mutation_p.Q436*|ACSBG2_uc002meg.1_Nonsense_Mutation_p.Q623*|ACSBG2_uc002meh.1_Nonsense_Mutation_p.Q623*|ACSBG2_uc002mei.1_Nonsense_Mutation_p.Q573*|ACSBG2_uc010xiz.1_Nonsense_Mutation_p.Q595*	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	623					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						GAACAATGCACAGAGGATTGA	0.507		NA											54	159					0	0	0	0
ZNF266	10781	broad.mit.edu	37	19	9524051	9524051	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:9524051T>C	uc002mll.2	-	4	1816	c.1550A>G	c.(1549-1551)GAG>GGG	p.E517G	ZNF266_uc002mlm.2_Missense_Mutation_p.E517G|ZNF266_uc002mln.2_Missense_Mutation_p.E517G|ZNF266_uc002mlo.2_Missense_Mutation_p.E517G|ZNF266_uc010dwp.2_Missense_Mutation_p.E517G|ZNF266_uc010dwq.2_Missense_Mutation_p.E517G	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAGGGTTTCTCTCCAGTGTG	0.438		NA											47	116					0	0	0	0
PODNL1	79883	broad.mit.edu	37	19	14044707	14044707	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:14044707C>G	uc002mxr.2	-	7	1046	c.772G>C	c.(772-774)GAT>CAT	p.D258H	PODNL1_uc010xni.1_Missense_Mutation_p.D176H|PODNL1_uc010xnj.1_Missense_Mutation_p.D256H|PODNL1_uc002mxs.2_Missense_Mutation_p.D167H	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	258	Leu-rich.|LRR 8.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			GTGGTGGCATCCAGGCCACTG	0.612		NA											3	17					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363783	22363783	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:22363783T>C	uc002nqs.1	-	3	1054	c.736A>G	c.(736-738)ATT>GTT	p.I246V		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	246	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCAGTATGAATTATCTTATGT	0.358		NA											17	194					0	0	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594389	41594389	+	Missense_Mutation	SNP	G	G	A	rs71579358		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:41594389G>A	uc002opt.2	+	1	22	c.13G>A	c.(13-15)GGG>AGG	p.G5R		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	5					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding	p.G5E(1)		ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GCTGGCCTCAGGGCTGCTTCT	0.557		NA											17	52					0	0	0	0
CCDC9	26093	broad.mit.edu	37	19	47763905	47763905	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:47763905A>T	uc010xym.1	+	5	478	c.271A>T	c.(271-273)AAG>TAG	p.K91*		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	91	Gly-rich.										0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGGGCCAGCAAGGGGGGCCG	0.706		NA											28	96					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50785002	50785002	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:50785002G>A	uc002prr.1	+	31	4366	c.4319G>A	c.(4318-4320)CGC>CAC	p.R1440H	MYH14_uc010enu.1_Missense_Mutation_p.R1481H|MYH14_uc002prq.1_Missense_Mutation_p.R1448H|MYH14_uc010ycb.1_Intron	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1440	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CGGGGCCGCCGCCGGCTGCAG	0.701		NA											5	15					0	0	0	0
C19orf75	284369	broad.mit.edu	37	19	51768727	51768727	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:51768727G>A	uc002pwb.1	+	3	509	c.128G>A	c.(127-129)GGA>GAA	p.G43E	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	43						integral to membrane				ovary(1)|pancreas(1)	2						TGGATGGGAGGAGTCCCCGTG	0.577		NA											46	85					0	0	0	0
ZNF578	147660	broad.mit.edu	37	19	53015012	53015012	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:53015012T>G	uc002pzp.3	+	6	1622	c.1378T>G	c.(1378-1380)TGT>GGT	p.C460G		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	235	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATGTGAAGAATGTGACAGAGT	0.378		NA											24	77					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54327177	54327177	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:54327177G>A	uc002qch.3	-	1	472	c.252C>T	c.(250-252)GAC>GAT	p.D84D	NLRP12_uc002qci.3_Silent_p.D84D|NLRP12_uc002qcj.3_Silent_p.D84D|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.D84D	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	84	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCCCACAGGTCCTTCCTGT	0.532		NA											94	216					0	0	0	0
LAIR2	3904	broad.mit.edu	37	19	55020273	55020273	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:55020273C>A	uc002qgc.2	+	4	515	c.393C>A	c.(391-393)GAC>GAA	p.D131E	LAIR2_uc002qgd.2_Intron|LAIR2_uc010erl.2_Missense_Mutation_p.T100K	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	131						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		ACTCCCCGGACACAGAGCCCG	0.632		NA											20	53					1.43e-11	1.58e-11	1	0
FIZ1	84922	broad.mit.edu	37	19	56104586	56104586	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:56104586C>A	uc002qli.3	-	3	811	c.721G>T	c.(721-723)GCG>TCG	p.A241S	FIZ1_uc002qlj.3_Missense_Mutation_p.A241S	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	241	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TCCAGCAGCGCGGGCGCGTTG	0.582		NA											8	10					1.13e-05	1.19e-05	1	0
NLRP13	126204	broad.mit.edu	37	19	56422072	56422072	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:56422072G>A	uc010ygg.1	-	6	2164	c.2139C>T	c.(2137-2139)CAC>CAT	p.H713H		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	713							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTTCCATGCGTGCATCCTGG	0.463		NA											44	129					0	0	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358		NA											2	11					0	0	0	0
NCOA1	8648	broad.mit.edu	37	2	24905933	24905933	+	Silent	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:24905933C>G	uc002rfk.2	+	6	726	c.468C>G	c.(466-468)GTC>GTG	p.V156V	NCOA1_uc010eye.2_Silent_p.V156V|NCOA1_uc002rfi.2_Silent_p.V5V|NCOA1_uc002rfj.2_Silent_p.V156V|NCOA1_uc002rfl.2_Silent_p.V156V	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	156	PAS.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACGAGCGTCTACAGCATAC	0.373		NA	T	PAX3	alveolar rhadomyosarcoma								27	84					0	0	0	0
IFT172	26160	broad.mit.edu	37	2	27668659	27668659	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:27668659T>C	uc002rku.2	-	45	4918	c.4867A>G	c.(4867-4869)ACA>GCA	p.T1623A	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1623					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GGAATGTCTGTATCCTGAAAA	0.542		NA											48	118					0	0	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43980883	43980883	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:43980883C>T	uc010yny.1	+	25	3862	c.3779C>T	c.(3778-3780)GCA>GTA	p.A1260V		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1260	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTAGAAATGGCAGCTCTTTTA	0.299		NA											58	86					0	0	0	0
REL	5966	broad.mit.edu	37	2	61118932	61118932	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:61118932A>T	uc002sam.1	+	2	349	c.125A>T	c.(124-126)GAC>GTC	p.D42V	REL_uc002san.1_Missense_Mutation_p.D42V	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	42	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			CACAGCACAGACAACAACCGA	0.413		NA	A		Hodgkin Lymphoma								50	139					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97779626	97779626	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:97779626C>G	uc010yva.1	+	1	394	c.150C>G	c.(148-150)TAC>TAG	p.Y50*	ANKRD36_uc002sxn.2_Nonsense_Mutation_p.Y50*|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Nonsense_Mutation_p.Y50*|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	50	ANK 1.										0						AACTGAAGTACCTTCTGCTCA	0.517		NA											29	56					0	0	0	0
TBC1D8	11138	broad.mit.edu	37	2	101627939	101627939	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:101627939C>G	uc010fiv.2	-	18	2977	c.2846G>C	c.(2845-2847)AGA>ACA	p.R949T	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.R706T	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	949					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						AACCAGGGGTCTCGATGTTGA	0.483		NA											42	79					0	0	0	0
PCDP1	200373	broad.mit.edu	37	2	120388230	120388230	+	Silent	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:120388230C>A	uc002tmb.2	+	19	2050	c.958C>A	c.(958-960)CGA>AGA	p.R320R	PCDP1_uc010yyq.1_Silent_p.R450R	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	606						cilium	calmodulin binding				0	Colorectal(110;0.196)					AAAGCTTGCCCGAGCCCTAAA	0.448		NA											26	60					7.88e-20	8.86e-20	1	0
LRP1B	53353	broad.mit.edu	37	2	141083449	141083449	+	Splice_Site	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:141083449T>A	uc002tvj.1	-	80	13196	c.12224_splice	c.e80-1	p.G4075_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGCCAAACCTGCAAAATCAA	0.348		NA								TSP Lung(27;0.18)			19	35					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141777529	141777529	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:141777529C>A	uc002tvj.1	-	12	2904	c.1932G>T	c.(1930-1932)ATG>ATT	p.M644I	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	644	Extracellular (Potential).|LDL-receptor class B 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGGATGAGACATTTCACCCT	0.368		NA								TSP Lung(27;0.18)			35	113					9.89e-21	1.11e-20	1	0
TNFAIP6	7130	broad.mit.edu	37	2	152235971	152235971	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:152235971C>T	uc002txk.2	+	6	834	c.758C>T	c.(757-759)TCC>TTC	p.S253F		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	253					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GTATCCAAATCCAGTCAAGGA	0.338		NA											62	165					0	0	0	0
PPP1R1C	151242	broad.mit.edu	37	2	182852607	182852607	+	Silent	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:182852607C>G	uc002uoo.2	+	2	410	c.123C>G	c.(121-123)CTC>CTG	p.L41L	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Silent_p.L41L|PPP1R1C_uc010frm.1_Silent_p.L48L|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	41					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			TTGTGATTCTCAATGAGCATA	0.408		NA											86	189					0	0	0	0
ALS2CR4	65062	broad.mit.edu	37	2	202492078	202492078	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:202492078G>A	uc002uyh.1	-	12	1104	c.1003C>T	c.(1003-1005)CTT>TTT	p.L335F	ALS2CR4_uc002uyg.1_Missense_Mutation_p.L327F|ALS2CR4_uc010zho.1_Missense_Mutation_p.L130F	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	359						integral to membrane	protein binding				0						GGTGTGTAAAGGTGGATTCTG	0.333		NA											3	15					0	0	0	0
WDR12	55759	broad.mit.edu	37	2	203760839	203760839	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:203760839T>A	uc002uzl.2	-	6	1308	c.558A>T	c.(556-558)AGA>AGT	p.R186S	WDR12_uc010ftt.2_Missense_Mutation_p.R186S	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	186	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CAGCATGACCTCTACAGCAGT	0.378		NA											53	129					0	0	0	0
ABCA12	26154	broad.mit.edu	37	2	215976352	215976352	+	Missense_Mutation	SNP	C	C	T	rs113648834		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:215976352C>T	uc002vew.2	-	2	351	c.131G>A	c.(130-132)CGG>CAG	p.R44Q	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	44					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAATTTGGTCCGAGTAATAGC	0.299		NA											29	89					0	0	0	0
SPEG	10290	broad.mit.edu	37	2	220354645	220354645	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:220354645C>T	uc010fwg.2	+	36	8905	c.8905C>T	c.(8905-8907)CTG>TTG	p.L2969L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2969	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTACACCTTCCTGGAGGAGAA	0.612		NA											19	55					0	0	0	0
HJURP	55355	broad.mit.edu	37	2	234749404	234749404	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:234749404C>T	uc002vvg.2	-	8	2088	c.2022G>A	c.(2020-2022)AGG>AGA	p.R674R	HJURP_uc010znd.1_Silent_p.R613R|HJURP_uc010zne.1_Silent_p.R582R	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	674					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACTGATGGTCCCTCGTGCCAT	0.577		NA											48	107					0	0	0	0
TNFRSF6B	8771	broad.mit.edu	37	20	62329691	62329691	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr20:62329691C>G	uc002yfy.2	+	7	1112	c.678C>G	c.(676-678)ATC>ATG	p.I226M	RTEL1_uc002yfw.2_RNA|TNFRSF6B_uc002yfz.2_Missense_Mutation_p.I226M	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	226					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			ACATCTCCATCAAGAGGCTGC	0.672		NA											11	43					0	0	0	0
TRPM2	7226	broad.mit.edu	37	21	45837865	45837865	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:45837865C>T	uc002zet.1	+	22	3415	c.3202C>T	c.(3202-3204)CAT>TAT	p.H1068Y	TRPM2_uc002zeu.1_Missense_Mutation_p.H1068Y|TRPM2_uc002zew.1_Missense_Mutation_p.H1068Y|TRPM2_uc010gpt.1_Missense_Mutation_p.H1068Y|TRPM2_uc002zex.1_Missense_Mutation_p.H854Y|TRPM2_uc002zey.1_Missense_Mutation_p.H581Y|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1068	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTCCAGCGCCATGACCTGAT	0.488		NA											34	77					0	0	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057446	46057446	+	Silent	SNP	T	T	C	rs444891	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:46057446T>C	uc002zfq.2	+	1	174	c.112T>C	c.(112-114)TTG>CTG	p.L38L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	38	15 X 5 AA repeats of C-C-X(3).					keratin filament					0						AGCCCCCAGCTTGACCCTGGT	0.662		NA											4	73					0	0	0	0
COL6A1	1291	broad.mit.edu	37	21	47410318	47410318	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:47410318C>T	uc002zhu.1	+	13	1086	c.984C>T	c.(982-984)GAC>GAT	p.D328D		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	328	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GTGGCATCGACGGGGTGGACG	0.438		NA											19	56					0	0	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41736067	41736067	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr22:41736067C>T	uc003azw.2	+	10	1280	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	371					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CTGCCGTACTCGGAGACCCGG	0.652		NA											20	61					0	0	0	0
PARP9	83666	broad.mit.edu	37	3	122269638	122269638	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:122269638A>C	uc010hri.2	-	6	1369	c.1224T>G	c.(1222-1224)CAT>CAG	p.H408Q	PARP9_uc003eff.3_Missense_Mutation_p.H373Q|PARP9_uc011bjs.1_Missense_Mutation_p.H373Q|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.H373Q|PARP9_uc003efh.2_Missense_Mutation_p.H408Q|PARP9_uc003efj.2_Missense_Mutation_p.H373Q	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	408	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		CCTTCATTGCATGTTTTAATA	0.378		NA											23	64					0	0	0	0
ROPN1	54763	broad.mit.edu	37	3	123695771	123695771	+	Silent	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:123695771T>C	uc003eha.2	-	4	515	c.174A>G	c.(172-174)CGA>CGG	p.R58R		NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	58					signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		ACAAAGCGACTCGCTCAGACC	0.517		NA											44	106					0	0	0	0
SNX4	8723	broad.mit.edu	37	3	125176125	125176125	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:125176125C>T	uc003eib.2	-	11	1071	c.1029G>A	c.(1027-1029)GAG>GAA	p.E343E	SNX4_uc011bkf.1_Silent_p.E198E	NM_003794	NP_003785	O95219	SNX4_HUMAN	sorting nexin 4	343					cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4						TTACCAGTTCCTCACACTGCT	0.458		NA											39	111					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130289727	130289727	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:130289727G>C	uc010htl.2	+	6	2498	c.2467G>C	c.(2467-2469)GAT>CAT	p.D823H		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	823	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TATTGACTATGATGAGTATAA	0.398		NA											30	84					0	0	0	0
TM4SF1	4071	broad.mit.edu	37	3	149089577	149089577	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:149089577G>A	uc003exb.1	-	4	725	c.491C>T	c.(490-492)TCT>TTT	p.S164F	TM4SF1_uc003exc.1_Missense_Mutation_p.S75F	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	164	Helical; (Probable).					integral to plasma membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CAAGAGGATAGAAAACAGAGA	0.433		NA											46	90					0	0	0	0
ACTL6A	86	broad.mit.edu	37	3	179291189	179291189	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:179291189G>A	uc003fjw.2	+	4	483	c.310G>A	c.(310-312)GAT>AAT	p.D104N	ACTL6A_uc003fjx.2_Missense_Mutation_p.D62N|ACTL6A_uc003fjy.2_Missense_Mutation_p.D62N	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	104					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			AGCTATTTTGGATCATACCTA	0.358		NA											40	98					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193220338	193220338	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:193220338G>C	uc003ftd.2	-	3	433	c.325C>G	c.(325-327)CTC>GTC	p.L109V	ATP13A4_uc003fte.1_Missense_Mutation_p.L109V|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	109	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TCTGTCATGAGAGGGTGGTCA	0.398		NA											60	122					0	0	0	0
ADD1	118	broad.mit.edu	37	4	2896318	2896318	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:2896318A>C	uc003gfr.2	+	6	789	c.601A>C	c.(601-603)AAT>CAT	p.N201H	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.N201H|ADD1_uc003gfo.2_Missense_Mutation_p.N201H|ADD1_uc003gfp.2_Missense_Mutation_p.N201H|ADD1_uc003gfq.2_Missense_Mutation_p.N201H|ADD1_uc003gfs.2_Missense_Mutation_p.N201H|ADD1_uc003gft.3_Missense_Mutation_p.N201H|ADD1_uc003gfu.2_5'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	201					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGTTAAGATCAATCTACAAGG	0.313		NA											16	30					0	0	0	0
NPFFR2	10886	broad.mit.edu	37	4	73012714	73012714	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:73012714C>A	uc003hgg.2	+	4	852	c.754C>A	c.(754-756)CCT>ACT	p.P252T	NPFFR2_uc010iig.1_Missense_Mutation_p.P34T|NPFFR2_uc003hgi.2_Missense_Mutation_p.P153T|NPFFR2_uc003hgh.2_Missense_Mutation_p.P150T|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	252	Cytoplasmic (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TGTGGTCTACCCTTTTAAACC	0.378		NA											98	280					3.78e-48	4.31e-48	1	0
RAP1GDS1	5910	broad.mit.edu	37	4	99358174	99358174	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:99358174A>G	uc003htx.3	+	14	1841	c.1651A>G	c.(1651-1653)ATC>GTC	p.I551V	RAP1GDS1_uc003htw.3_Missense_Mutation_p.I552V|RAP1GDS1_uc003htv.3_Missense_Mutation_p.I551V|RAP1GDS1_uc003htz.3_Missense_Mutation_p.I502V|RAP1GDS1_uc003hty.3_Missense_Mutation_p.I503V|RAP1GDS1_uc003hua.3_Missense_Mutation_p.I460V	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	551							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TGCTCCTGAAATCAAATATAA	0.343		NA	T	NUP98	T-ALL								37	59					0	0	0	0
FBXO8	26269	broad.mit.edu	37	4	175160279	175160279	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:175160279G>A	uc003itp.2	-	5	1488	c.638C>T	c.(637-639)GCA>GTA	p.A213V	FBXO8_uc003itq.2_Missense_Mutation_p.A172V	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	213	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		TTCTCTCAGTGCATTTGGCAA	0.378		NA											17	80					0	0	0	0
WDR17	116966	broad.mit.edu	37	4	177067239	177067239	+	Silent	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:177067239T>C	uc003iuj.2	+	13	1851	c.1695T>C	c.(1693-1695)CAT>CAC	p.H565H	WDR17_uc003iuk.2_Silent_p.H541H|WDR17_uc003ium.3_Silent_p.H541H|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	565	WD 10.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTAGTGGGCATACAGCAAAAG	0.388		NA											40	166					0	0	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	171356	171356	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:171356A>G	uc003jak.2	+	14	2829	c.2779A>G	c.(2779-2781)ATG>GTG	p.M927V		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	927	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGGTGACAAAATGGACCTGGC	0.697		NA											46	19					0	0	0	0
FASTKD3	79072	broad.mit.edu	37	5	7867445	7867445	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:7867445A>T	uc003jeb.2	-	2	889	c.752T>A	c.(751-753)TTT>TAT	p.F251Y	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	251					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CTCCGGGGTAAATGTTTCCAA	0.363		NA											43	296					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24498538	24498538	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:24498538G>T	uc003jgr.1	-	9	1816	c.1484C>A	c.(1483-1485)ACT>AAT	p.T495N	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	495	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACATACAAAAGTGTCATAGAA	0.393		NA								HNSCC(23;0.051)			27	232					4.23e-11	4.66e-11	1	0
CDH10	1008	broad.mit.edu	37	5	24498580	24498580	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:24498580T>A	uc003jgr.1	-	9	1774	c.1442A>T	c.(1441-1443)GAT>GTT	p.D481V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	481	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTCATTAACATCCAAAATTCT	0.408		NA								HNSCC(23;0.051)			33	238					0	0	0	0
PDZD2	23037	broad.mit.edu	37	5	32058193	32058193	+	Silent	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:32058193A>G	uc003jhl.2	+	12	2572	c.2184A>G	c.(2182-2184)GAA>GAG	p.E728E	PDZD2_uc003jhm.2_Silent_p.E728E|PDZD2_uc011cnx.1_Silent_p.E554E	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	728	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TCGTCATGGAAGTAACACTCA	0.468		NA											10	102					0	0	0	0
TRPC7	57113	broad.mit.edu	37	5	135587503	135587503	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:135587503C>T	uc003lbn.1	-	5	1413	c.1410G>A	c.(1408-1410)TGG>TGA	p.W470*	TRPC7_uc010jef.1_Nonsense_Mutation_p.W407*|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Nonsense_Mutation_p.W401*|TRPC7_uc010jei.1_Nonsense_Mutation_p.W346*|TRPC7_uc010jej.1_Nonsense_Mutation_p.W22*	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	471	Helical; (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTAGCAGGTTCCACAAGTGCA	0.567		NA											32	47					0	0	0	0
HIVEP1	3096	broad.mit.edu	37	6	12015862	12015862	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:12015862A>T	uc003nac.2	+	2	180	c.1A>T	c.(1-3)ATG>TTG	p.M1L		NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTCAAAGAAGATGCCTCGAAC	0.358		NA											33	103					0	0	0	0
MCM3	4172	broad.mit.edu	37	6	52129395	52129395	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:52129395G>T	uc003pan.1	-	17	2528	c.2418C>A	c.(2416-2418)TTC>TTA	p.F806L	MCM3_uc011dwu.1_Missense_Mutation_p.F760L	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	806					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CTCAGATGAGGAAGATGATGC	0.542		NA											36	112					3.63e-18	4.05e-18	1	0
BAI3	577	broad.mit.edu	37	6	69703805	69703805	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:69703805C>A	uc003pev.3	+	11	2328	c.1880C>A	c.(1879-1881)ACA>AAA	p.T627K	BAI3_uc010kak.2_Missense_Mutation_p.T627K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	627	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGAAATGTGACAGACACATTT	0.443		NA											46	122					1.17e-09	1.28e-09	1	0
ZNF292	23036	broad.mit.edu	37	6	87969654	87969654	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:87969654G>C	uc003plm.3	+	8	6348	c.6307G>C	c.(6307-6309)GAG>CAG	p.E2103Q		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CCAATCCCTTGAGTTTCCAAC	0.413		NA											29	89					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90385185	90385185	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:90385185G>A	uc003pnn.1	-	78	12875	c.12759C>T	c.(12757-12759)CTC>CTT	p.L4253L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4253					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCTGATACCTGAGGATGATCC	0.527		NA											29	69					0	0	0	0
ASCC3	10973	broad.mit.edu	37	6	101037629	101037629	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:101037629C>T	uc003pqk.2	-	36	5760	c.5431G>A	c.(5431-5433)GAA>AAA	p.E1811K		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GTTAGAGGTTCAATGCTGCGA	0.343		NA											61	160					0	0	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111913273	111913273	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:111913273G>A	uc011ebc.1	-	3	632	c.17C>T	c.(16-18)CCT>CTT	p.P6L	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.P6L|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.P6L|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.P6L|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.P6L	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	15					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AACCTCCACAGGAATGCTTCG	0.423		NA											48	125					0	0	0	0
PAPOLB	56903	broad.mit.edu	37	7	4900071	4900071	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:4900071G>A	uc003snk.2	-	1	1555	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	456					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TATCATAGGTGAGATCAATGC	0.363		NA											92	122					0	0	0	0
POU6F2	11281	broad.mit.edu	37	7	39247047	39247047	+	Silent	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:39247047C>A	uc003thb.1	+	4	381	c.339C>A	c.(337-339)GGC>GGA	p.G113G	POU6F2_uc010kxo.2_Silent_p.G105G	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	113					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TGCCGGGAGGCCCCCCAGCCC	0.577		NA											79	200					1.32e-37	1.5e-37	1	0
STX1A	6804	broad.mit.edu	37	7	73115164	73115164	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:73115164T>A	uc003tyx.2	-	9	712	c.685A>T	c.(685-687)ATG>TTG	p.M229L	WBSCR22_uc003tyw.1_Intron|STX1A_uc003tyy.2_Intron|STX1A_uc010lbj.1_Missense_Mutation_p.D259V	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1	229	Cytoplasmic (Potential).|t-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTGTCAATCATCTCTCCCTGC	0.627		NA											13	23					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82784471	82784471	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:82784471A>G	uc003uhx.2	-	2	1775	c.1486T>C	c.(1486-1488)TCA>CCA	p.S496P	PCLO_uc003uhv.2_Missense_Mutation_p.S496P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTTTGCTGAGCCAGGCTGT	0.607		NA											10	157					0	0	0	0
MFHAS1	9258	broad.mit.edu	37	8	8750418	8750418	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:8750418G>A	uc003wsj.1	-	1	714	c.151C>T	c.(151-153)CCC>TCC	p.P51S		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	51											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GGGGAGGCGGGGGACTCGAGC	0.587		NA											3	6					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68102908	68102908	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:68102908G>A	uc003xxi.2	+	29	3365	c.3334G>A	c.(3334-3336)GCC>ACC	p.A1112T	ARFGEF1_uc003xxl.1_Intron|CSPP1_uc003xxj.2_Missense_Mutation_p.A1077T|CSPP1_uc003xxk.2_Missense_Mutation_p.A732T|CSPP1_uc010lyw.2_Missense_Mutation_p.A172T	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1112						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GACATATCCTGCCATTGAAGA	0.483		NA											38	81					0	0	0	0
TERF1	7013	broad.mit.edu	37	8	73926133	73926133	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:73926133T>G	uc003xzd.2	+	2	348	c.323T>G	c.(322-324)ATT>AGT	p.I108S	TERF1_uc003xzc.2_RNA|TERF1_uc003xze.2_Missense_Mutation_p.I108S	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	108	TRFH dimerization.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			TTTTTAGCTATTATTCATGGA	0.323		NA											39	94					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617964	77617964	+	Silent	SNP	T	T	C	rs74886598		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:77617964T>C	uc003yav.2	+	2	2028	c.1641T>C	c.(1639-1641)AGT>AGC	p.S547S	ZFHX4_uc003yat.1_Silent_p.S547S|ZFHX4_uc003yau.1_Silent_p.S547S|ZFHX4_uc003yaw.1_Silent_p.S547S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	547						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGTGGCAGTGTTGCTAGTA	0.488		NA								HNSCC(33;0.089)			6	31					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92972691	92972691	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:92972691C>A	uc003yfd.2	-	11	1678	c.1594G>T	c.(1594-1596)GCC>TCC	p.A532S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.A505S|RUNX1T1_uc003yfe.1_Missense_Mutation_p.A495S|RUNX1T1_uc010mao.2_Missense_Mutation_p.A505S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.A543S|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Missense_Mutation_p.A157S|RUNX1T1_uc003yfb.1_Missense_Mutation_p.A495S	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	532	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGTATCGGGCTGTGTTACAG	0.522		NA											16	49					0.000422831	0.000441541	1	0
CSMD3	114788	broad.mit.edu	37	8	113697694	113697694	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:113697694C>T	uc003ynu.2	-	15	2582	c.2423G>A	c.(2422-2424)CGA>CAA	p.R808Q	CSMD3_uc003yns.2_Missense_Mutation_p.R80Q|CSMD3_uc003ynt.2_Missense_Mutation_p.R768Q|CSMD3_uc011lhx.1_Missense_Mutation_p.R704Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	808	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATTCCAATCGCAGTATGTG	0.408		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	97					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77397710	77397710	+	Silent	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:77397710C>T	uc004ajl.1	-	22	3217	c.2979G>A	c.(2977-2979)GTG>GTA	p.V993V	TRPM6_uc004ajk.1_Silent_p.V988V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Silent_p.V279V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	993	Helical; (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CCTTGCGTGCCACTCCAAAGC	0.438		NA											33	33					0	0	0	0
OR13C9	286362	broad.mit.edu	37	9	107380278	107380278	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:107380278C>A	uc011lvr.1	-	1	208	c.208G>T	c.(208-210)GAC>TAC	p.D70Y		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAGCAGATGTCCAAGAAGGAG	0.478		NA											48	124					4.45e-29	5.03e-29	1	0
TNC	3371	broad.mit.edu	37	9	117848842	117848842	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:117848842C>T	uc004bjj.3	-	3	1530	c.1168G>A	c.(1168-1170)GGG>AGG	p.G390R	TNC_uc010mvf.2_Missense_Mutation_p.G390R	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	390	EGF-like 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCACACCGCCCGTCTACACAG	0.587		NA											33	104					0	0	0	0
GAPVD1	26130	broad.mit.edu	37	9	128112629	128112629	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:128112629C>T	uc010mwx.2	+	22	3735	c.3409C>T	c.(3409-3411)CCA>TCA	p.P1137S	GAPVD1_uc004bpp.2_Missense_Mutation_p.P1146S|GAPVD1_uc004bpq.2_Missense_Mutation_p.P1119S|GAPVD1_uc004bpr.2_Missense_Mutation_p.P1098S|GAPVD1_uc004bps.2_Missense_Mutation_p.P1092S|GAPVD1_uc004bpt.2_Missense_Mutation_p.P152S	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1137					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TGTTGCCTTCCCAGTGCTGAC	0.383		NA											99	87					0	0	0	0
ST6GALNAC6	30815	broad.mit.edu	37	9	130652958	130652958	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:130652958C>T	uc004bso.1	-	5	781	c.662G>A	c.(661-663)CGG>CAG	p.R221Q	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.R187Q|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.R221Q|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.R187Q|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.R187Q|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	221	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						GTCAAATTGCCGCATGCGGCC	0.642		NA											69	54					0	0	0	0
SEC16A	9919	broad.mit.edu	37	9	139339534	139339534	+	Silent	SNP	T	T	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:139339534T>C	uc004chx.2	-	30	7206	c.6897A>G	c.(6895-6897)TTA>TTG	p.L2299L	SEC16A_uc004chp.2_Intron|SEC16A_uc004chq.2_Intron|SEC16A_uc011mea.1_Intron|SEC16A_uc004chr.2_Silent_p.L327L|SEC16A_uc004chs.2_Silent_p.L139L|SEC16A_uc004cht.2_Silent_p.L349L|SEC16A_uc004chu.2_Silent_p.L506L|SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Silent_p.L2274L|SEC16A_uc010nbn.2_Intron	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	2121	Required for interaction with SEC23A.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTTCACGTGATAATGAACTCA	0.498		NA											7	9					0	0	0	0
MAN1B1	11253	broad.mit.edu	37	9	139990685	139990687	+	Splice_Site	TNP	ACA	ACA	TAC			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:139990685_139990687ACA>TAC	uc004cld.2	+	4	501	c.466_splice	c.e4-2	p.K156_splice	MAN1B1_uc004clc.2_Splice_Site_p.K57_splice|MAN1B1_uc011meo.1_Splice_Site_p.K57_splice|MAN1B1_uc011mep.1_Splice_Site_p.K156_splice|MAN1B1_uc010ncc.2_Splice_Site	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase						oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CAATTTCTCTACAGAAGACACAA	0.567		NA											9	23					0	0	0	0
MRPL41	64975	broad.mit.edu	37	9	140446898	140446898	+	Missense_Mutation	SNP	C	C	A	rs3210506		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:140446898C>A	uc004cnh.3	+	2	495	c.365C>A	c.(364-366)ACA>AAA	p.T122K	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	122					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		TTCGAGCCCACACAGGAGGGA	0.592		NA											4	76					0.00024832	0.000259883	1	0
WDR85	92715	broad.mit.edu	37	9	140473185	140473185	+	Silent	SNP	G	G	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:140473185G>A	uc004cnk.1	-	1	203	c.45C>T	c.(43-45)ACC>ACT	p.T15T	WDR85_uc004cnl.1_5'UTR|WDR85_uc004cnm.1_5'UTR|WDR85_uc004cnn.1_5'UTR	NM_138778	NP_620133	Q9BTV6	WDR85_HUMAN	WD repeat domain 85	15					peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)		CCGAGTCCGCGGTCAGCTCGG	0.746		NA											7	2					0	0	0	0
FAM47A	158724	broad.mit.edu	37	X	34149589	34149589	+	Silent	SNP	A	A	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:34149589A>C	uc004ddg.2	-	1	840	c.807T>G	c.(805-807)TCT>TCG	p.S269S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	269										ovary(4)|central_nervous_system(1)	5						GCTTCCTCTCAGAATCCAGTT	0.587		NA											22	26					0	0	0	0
SRPX	8406	broad.mit.edu	37	X	38024064	38024064	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:38024064T>A	uc004ddy.1	-	5	697	c.611A>T	c.(610-612)GAG>GTG	p.E204V	SRPX_uc004ddz.1_Missense_Mutation_p.E184V|SRPX_uc011mkh.1_Missense_Mutation_p.E145V|SRPX_uc011mki.1_Missense_Mutation_p.E204V	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	204	HYR.				cell adhesion	cell surface|membrane					0						TTCGGGTGTCTCCCAGGACAC	0.433		NA											5	34					0	0	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450134	105450134	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:105450134G>T	uc004emf.1	+	4	1358	c.709G>T	c.(709-711)GCT>TCT	p.A237S	MUM1L1_uc004emg.1_Missense_Mutation_p.A237S	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	237										ovary(2)|pancreas(1)|skin(1)	4						TGAAAAGTTTGCTCCACCTTT	0.418		NA											15	10					2.23e-06	2.38e-06	1	0
ODZ1	10178	broad.mit.edu	37	X	123699280	123699280	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:123699280G>T	uc004euj.2	-	12	2272	c.2208C>A	c.(2206-2208)TGC>TGA	p.C736*	ODZ1_uc011muj.1_Nonsense_Mutation_p.C735*|ODZ1_uc010nqy.2_Nonsense_Mutation_p.C736*	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	736	EGF-like 7.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTCCATCTTTGCATTGGCCAT	0.468		NA											4	56					0.00909568	0.00931271	1	0
FAF1	11124	broad.mit.edu	37	1	51050366	51050367	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:51050366_51050367insT	uc009vyx.1	-	11	1020_1021	c.957_958insA	c.(955-960)AAATCTfs	p.K319fs	FAF1_uc009vyw.1_Intron|FAF1_uc001cse.1_Frame_Shift_Ins_p.K319fs|FAF1_uc010onc.1_Frame_Shift_Ins_p.K77fs	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	319_320					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		CTCATTGGAGATTTTCTCAAGG	0.376		NA											45	143	---	---	---	---	NA	NA	NA	NA
PPAP2B	8613	broad.mit.edu	37	1	56990179	56990179	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:56990179delC	uc001cyj.1	-	4	846	c.345delG	c.(343-345)CGGfs	p.R115fs		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	115	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						GAATCGTCGACCGCGACTTCT	0.483		NA											30	100	---	---	---	---	NA	NA	NA	NA
OR5P2	120065	broad.mit.edu	37	11	7817968	7817969	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:7817968_7817969insA	uc001mfp.1	-	1	521_522	c.521_522insT	c.(520-522)TTCfs	p.F174fs		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGAAATCACAGAAAAAATGATT	0.386		NA											31	73	---	---	---	---	NA	NA	NA	NA
RASGRP1	10125	broad.mit.edu	37	15	38794593	38794594	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:38794593_38794594insT	uc001zke.3	-	12	1635_1636	c.1457_1458insA	c.(1456-1458)CAGfs	p.Q486fs	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Frame_Shift_Ins_p.Q313fs|RASGRP1_uc010bbg.2_Frame_Shift_Ins_p.Q313fs|RASGRP1_uc001zkd.3_Frame_Shift_Ins_p.Q451fs	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	486	1 (Potential).|EF-hand 1.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGTATCCATCCTGGTCGTGATC	0.391		NA											17	29	---	---	---	---	NA	NA	NA	NA
ACSF2	80221	broad.mit.edu	37	17	48540530	48540531	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:48540530_48540531insC	uc002iqu.2	+	7	910_911	c.806_807insC	c.(805-807)AGCfs	p.S269fs	ACSF2_uc010wml.1_Frame_Shift_Ins_p.S226fs|ACSF2_uc010wmm.1_Frame_Shift_Ins_p.S294fs|ACSF2_uc010wmn.1_Frame_Shift_Ins_p.S256fs|ACSF2_uc010wmo.1_Frame_Shift_Ins_p.S109fs	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	269	ATP (By similarity).				fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			ACAACAGGCAGCCCCAAGGGGG	0.53		NA											36	326	---	---	---	---	NA	NA	NA	NA
UGT1A1	54658	broad.mit.edu	37	2	234669681	234669682	+	Frame_Shift_Ins	INS	-	-	GGACAGTCAC	rs57307513	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:234669681_234669682insGGACAGTCAC	uc002vvb.2	+	1	763_764	c.748_749insGGACAGTCAC	c.(748-750)TCTfs	p.S250fs	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Frame_Shift_Ins_p.S250fs	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	250					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCTATTGAGCTCTGCATCTGTC	0.47		NA											24	280	---	---	---	---	NA	NA	NA	NA
SLC39A7	7922	broad.mit.edu	37	6	33171561	33171562	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:33171561_33171562insT	uc003odf.2	+	8	1498_1499	c.1381_1382insT	c.(1381-1383)ATGfs	p.M461fs	RXRB_uc011dqr.1_5'Flank|SLC39A7_uc003odg.2_Frame_Shift_Ins_p.M461fs|SLC39A7_uc011dqv.1_Frame_Shift_Ins_p.M336fs|SLC39A7_uc003odh.2_Frame_Shift_Ins_p.M109fs|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	461				CALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLP ELLREASPLQSLLEVLGLLGGVIMMVLIAHLE -> VPFSL KEEQWTVKLQVVQVLAGSCHLLQVALST (in Ref. 1; BAA11528 and 2; AAD12305).		endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						GGGAGTTATCATGATGGTGCTG	0.569		NA											23	114	---	---	---	---	NA	NA	NA	NA
GPR115	221393	broad.mit.edu	37	6	47682289	47682290	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:47682289_47682290insT	uc003oza.1	+	6	1566_1567	c.1308_1309insT	c.(1306-1311)TCATACfs	p.S436fs	GPR115_uc003oyz.1_Frame_Shift_Ins_p.S493fs|GPR115_uc003ozb.1_Frame_Shift_Ins_p.S434fs	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	436_437	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CGGAGATATCATACATGCGTCA	0.485		NA											89	241	---	---	---	---	NA	NA	NA	NA
KLHL31	401265	broad.mit.edu	37	6	53516534	53516534	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:53516534delG	uc003pcb.3	-	3	1908	c.1767delC	c.(1765-1767)CCCfs	p.P589fs	uc003pcc.1_5'UTR	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	589	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CGTTGAGCTCGGGGCTGAAGC	0.652		NA									OREG0017507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	97	---	---	---	---	NA	NA	NA	NA
