Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MRPL20	55052	broad.mit.edu	37	1	1342362	1342362	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:1342362G>A	uc001afo.3	-	2	221	c.125C>T	c.(124-126)GCG>GTG	p.A42V	MRPL20_uc010nyn.1_Missense_Mutation_p.A42V	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	42							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGTTCTGACCGCCAACCTGTA	0.488		NA											6	422					0	0	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521694	6521694	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:6521694G>A	uc001ane.2	-	10	1142	c.1054C>T	c.(1054-1056)CGC>TGC	p.R352C	TNFRSF25_uc001ana.2_Missense_Mutation_p.R169C|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Missense_Mutation_p.R125C|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.R315C|TNFRSF25_uc001ang.2_Missense_Mutation_p.R307C|TNFRSF25_uc001anh.2_Missense_Mutation_p.R361C	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	352	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCCAGCGTGCGCACGAACTCC	0.687		NA											8	35					0	0	0	0
MYCL1	4610	broad.mit.edu	37	1	40366778	40366778	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:40366778C>T	uc001cer.1	-	2	546	c.329G>A	c.(328-330)AGC>AAC	p.S110N	MYCL1_uc001ces.1_Missense_Mutation_p.S110N|MYCL1_uc001cet.1_Missense_Mutation_p.S110N	NM_001033082	NP_001028254	P12524	MYCL1_HUMAN	l-myc-1 proto-oncogene isoform 1	110						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|liver(1)	2	all_cancers(7;1.73e-14)|all_lung(5;2.77e-17)|all_epithelial(6;6.81e-17)|Lung SC(1;2.85e-13)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.51e-19)|Epithelial(16;3.36e-18)|all cancers(16;8.43e-17)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAGCCGGTCGCTCACAGCTCT	0.726		NA	A		small cell lung 								3	16					0	0	0	0
CRYZ	1429	broad.mit.edu	37	1	75172795	75172795	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:75172795G>A	uc001dgk.2	-	8	1229	c.724C>T	c.(724-726)CGA>TGA	p.R242*	CRYZ_uc001dgj.2_Nonsense_Mutation_p.R242*|CRYZ_uc001dgl.2_Intron|CRYZ_uc001dgm.2_Nonsense_Mutation_p.R105*	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	242					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	ACTATCACTCGTCCTCCATGT	0.274		NA											34	145					0	0	0	0
SNX7	51375	broad.mit.edu	37	1	99161197	99161197	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:99161197A>G	uc010ouc.1	+	5	815	c.763A>G	c.(763-765)AAC>GAC	p.N255D	SNX7_uc001dsa.2_Missense_Mutation_p.N191D|SNX7_uc010oud.1_Missense_Mutation_p.N200D	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	191					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		GGAAATGAATAACTTTATTGA	0.383		NA											23	113					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244		NA											3	171					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152187690	152187690	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152187690T>A	uc001ezt.1	-	3	6491	c.6415A>T	c.(6415-6417)AGA>TGA	p.R2139*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2139					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGATCTAGAGCCGTGT	0.572		NA											17	699					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152191224	152191224	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152191224C>T	uc001ezt.1	-	3	2957	c.2881G>A	c.(2881-2883)GGC>AGC	p.G961S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	961	10				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTAGAGCCGTGTTGTTCG	0.537		NA											102	382					0	0	0	0
OR10T2	128360	broad.mit.edu	37	1	158368907	158368907	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:158368907G>A	uc010pih.1	-	1	350	c.350C>T	c.(349-351)GCT>GTT	p.A117V		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TCCCATCACAGCAATGAGGAG	0.493		NA											4	155					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190423836	190423836	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:190423836T>G	uc001gse.1	-	2	417	c.185A>C	c.(184-186)GAT>GCT	p.D62A	FAM5C_uc010pot.1_Missense_Mutation_p.I24L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	62						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTCCACAAAATCTGTGTATTC	0.468		NA											18	64					0	0	0	0
CACNA1S	779	broad.mit.edu	37	1	201012531	201012531	+	Silent	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:201012531G>T	uc001gvv.2	-	40	5153	c.4926C>A	c.(4924-4926)GTC>GTA	p.V1642V		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1642	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTCCAAGAAGACAGGTGACT	0.542		NA									OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	112					3.11e-16	3.57e-16	1	0
CDC123	8872	broad.mit.edu	37	10	12259436	12259436	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:12259436C>T	uc001ill.2	+	6	694	c.410C>T	c.(409-411)TCC>TTC	p.S137F	CDC123_uc001ilm.2_Missense_Mutation_p.S137F	NM_006023	NP_006014	O75794	CD123_HUMAN	cell division cycle 123	137					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)	1						TTCAAGAGTTCCGATTTCATC	0.368		NA											14	141					0	0	0	0
C10orf111	221060	broad.mit.edu	37	10	15138710	15138710	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:15138710C>T	uc001inw.2	-	2	388	c.114G>A	c.(112-114)AAG>AAA	p.K38K	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	38						integral to membrane					0						CTGCCTTTCTCTTTTCGGGCT	0.498		NA											36	268					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63852230	63852230	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:63852230C>T	uc001jlt.1	+	10	3034	c.3008C>T	c.(3007-3009)CCG>CTG	p.P1003L		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1003					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					AAAATGAGCCCGCAGAACATT	0.552		NA											38	207					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69948722	69948722	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:69948722C>T	uc001jnm.3	+	14	2949	c.2764C>T	c.(2764-2766)CGT>TGT	p.R922C	MYPN_uc001jnn.3_Missense_Mutation_p.R647C|MYPN_uc001jno.3_Missense_Mutation_p.R922C|MYPN_uc009xpt.2_Missense_Mutation_p.R922C|MYPN_uc010qit.1_Missense_Mutation_p.R628C|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	922						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TCGCTTGGAACGTACTCCTGT	0.413		NA											15	63					0	0	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81154151	81154151	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:81154151G>A	uc001kak.2	-	3	680	c.493C>T	c.(493-495)CGC>TGC	p.R165C	ZCCHC24_uc010qlr.1_Missense_Mutation_p.A105V|ZCCHC24_uc009xrw.2_RNA	NM_153367	NP_699198	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	165							nucleic acid binding|zinc ion binding			breast(1)	1						CCGAAGCAGCGCTTTTTGCCC	0.567		NA											42	174					0	0	0	0
ZNF518A	9849	broad.mit.edu	37	10	97917661	97917661	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:97917661G>T	uc001klp.2	+	6	2439	c.1582G>T	c.(1582-1584)GAA>TAA	p.E528*	ZNF518A_uc001klo.1_5'UTR|ZNF518A_uc001klq.2_Nonsense_Mutation_p.E528*|ZNF518A_uc001klr.2_Nonsense_Mutation_p.E528*	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGCAAGTTCAGAAAAAGAAAT	0.323		NA											36	223					4.66e-17	5.38e-17	1	0
HMX3	340784	broad.mit.edu	37	10	124896943	124896943	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:124896943G>A	uc010quc.1	+	2	770	c.770G>A	c.(769-771)CGA>CAA	p.R257Q		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	257	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AGCTCGGAGCGAGCCGGCCTG	0.647		NA											12	65					0	0	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7670058	7670058	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:7670058A>T	uc001mfj.3	+	19	2213	c.1825A>T	c.(1825-1827)AGG>TGG	p.R609W	PPFIBP2_uc010rbb.1_Missense_Mutation_p.R532W|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.R543W|PPFIBP2_uc010rbe.1_Missense_Mutation_p.R497W|PPFIBP2_uc001mfl.3_Missense_Mutation_p.R466W|PPFIBP2_uc009yfj.1_Missense_Mutation_p.R253W	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	609	SAM 1.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCCACTCCACAGGAAGAAGCT	0.448		NA											57	233					0	0	0	0
ELP4	26610	broad.mit.edu	37	11	31671745	31671745	+	Silent	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:31671745A>G	uc001mtb.2	+	9	1154	c.1119A>G	c.(1117-1119)TTA>TTG	p.L373L	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.L373L|ELP4_uc010rdz.1_Silent_p.L374L	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	373					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CTTTTAAATTAAAAAGGAAGC	0.259		NA											16	69					0	0	0	0
LRP4	4038	broad.mit.edu	37	11	46903411	46903411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:46903411G>A	uc001ndn.3	-	20	2802	c.2656C>T	c.(2656-2658)CGA>TGA	p.R886*		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	886	Extracellular (Potential).|LDL-receptor class B 8.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATGCCAGCTCGTTCAATCTTG	0.507		NA											25	85					0	0	0	0
KDELC2	143888	broad.mit.edu	37	11	108350193	108350193	+	Silent	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:108350193G>T	uc001pkj.2	-	6	1194	c.1128C>A	c.(1126-1128)ACC>ACA	p.T376T	KDELC2_uc001pki.2_Silent_p.T320T	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	376						endoplasmic reticulum lumen		p.T376T(1)		ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AAGCAGCCACGGTCCCATCCA	0.408		NA											13	72					2.39e-15	2.73e-15	1	0
GLI1	2735	broad.mit.edu	37	12	57862003	57862003	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57862003C>T	uc001snx.2	+	10	1382	c.1304C>T	c.(1303-1305)GCC>GTC	p.A435V	GLI1_uc009zpq.2_Missense_Mutation_p.A307V	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	435					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCAGAGGGTGCCATGGTGAGA	0.582		NA											3	57					0	0	0	0
KIF5A	3798	broad.mit.edu	37	12	57968982	57968982	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57968982T>C	uc001sor.1	+	16	2040	c.1832T>C	c.(1831-1833)CTC>CCC	p.L611P	KIF5A_uc010srr.1_Missense_Mutation_p.L522P	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	611					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTGGAGAACCTCCAGGTGGAG	0.562		NA											10	40					0	0	0	0
KNTC1	9735	broad.mit.edu	37	12	123103082	123103082	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:123103082G>A	uc001ucv.2	+	59	6302	c.6139G>A	c.(6139-6141)GCT>ACT	p.A2047T	KNTC1_uc010taf.1_Missense_Mutation_p.A972T	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	2047					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GAGTCTCATCGCTGTCCTCGA	0.338		NA											19	57					0	0	0	0
FAM101A	144347	broad.mit.edu	37	12	124798975	124798975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:124798975C>A	uc001ugd.1	+	3	555	c.312C>A	c.(310-312)TGC>TGA	p.C104*	FAM101A_uc001uge.1_Nonsense_Mutation_p.C104*	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	185											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCCTGCACTGCAGCCTGGGCC	0.706		NA											11	45					0.000673444	0.000716484	1	0
RIMBP2	23504	broad.mit.edu	37	12	130921701	130921701	+	Missense_Mutation	SNP	C	C	T	rs139344487	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:130921701C>T	uc001uil.2	-	10	1905	c.1741G>A	c.(1741-1743)GTT>ATT	p.V581I	RIMBP2_uc001uim.2_Missense_Mutation_p.V489I|RIMBP2_uc001uin.1_Missense_Mutation_p.V240I	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	581						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGGGGGGAACGGCAGCAACT	0.662		NA											7	8					0	0	0	0
RCBTB2	1102	broad.mit.edu	37	13	49076887	49076887	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:49076887C>T	uc001vch.2	-	11	1461	c.1090G>A	c.(1090-1092)GCC>ACC	p.A364T	RCBTB2_uc010tgg.1_Missense_Mutation_p.A369T|RCBTB2_uc001vci.2_Missense_Mutation_p.A340T|RCBTB2_uc010tgh.1_Missense_Mutation_p.A90T|RCBTB2_uc001vcj.2_Missense_Mutation_p.A316T|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_3'UTR	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	364	RCC1 6.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACGTGACGGCGGGCGTGGCA	0.592		NA											27	119					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99554563	99554563	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:99554563G>A	uc001vnt.2	-	12	1417	c.1362C>T	c.(1360-1362)GCC>GCT	p.A454A	DOCK9_uc001vnw.2_Silent_p.A453A|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.A454A|DOCK9_uc010tis.1_Silent_p.A453A|DOCK9_uc010tit.1_Silent_p.A454A|DOCK9_uc010afu.1_Silent_p.A269A	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	454					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGCATGGCGGCTTCATGAA	0.532		NA											15	49					0	0	0	0
RAB2B	84932	broad.mit.edu	37	14	21936559	21936559	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:21936559G>A	uc010tlt.1	-	5	420	c.319C>T	c.(319-321)CAC>TAC	p.H107Y	RAB2B_uc010tls.1_Missense_Mutation_p.H61Y|RAB2B_uc001wax.2_Missense_Mutation_p.H42Y|RAB2B_uc010ain.2_Intron	NM_032846	NP_116235	Q8WUD1	RAB2B_HUMAN	RAB2B protein isoform 1	107					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			ovary(1)	1	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		GAACTAGAGTGCTGCCGGGCA	0.423		NA											10	49					0	0	0	0
TTC7B	145567	broad.mit.edu	37	14	91142993	91142993	+	Silent	SNP	G	G	A	rs149388931		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:91142993G>A	uc001xyp.2	-	9	1148	c.1026C>T	c.(1024-1026)GAC>GAT	p.D342D	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	342							binding			ovary(2)	2		Melanoma(154;0.222)				TCAGCACAGCGTCCCGGTTGG	0.532		NA											17	98					0	0	0	0
RASGRP1	10125	broad.mit.edu	37	15	38808519	38808519	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:38808519T>C	uc001zke.3	-	6	732	c.554A>G	c.(553-555)CAA>CGA	p.Q185R	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.Q47R|RASGRP1_uc010bbg.2_Missense_Mutation_p.Q47R|RASGRP1_uc001zkd.3_Missense_Mutation_p.Q185R	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	185					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTTTATCCTTTGAGTAAGTTT	0.443		NA											19	111					0	0	0	0
VPS13C	54832	broad.mit.edu	37	15	62299547	62299547	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:62299547G>A	uc002agz.2	-	15	1324	c.1250C>T	c.(1249-1251)ACA>ATA	p.T417I	VPS13C_uc002aha.2_Missense_Mutation_p.T374I|VPS13C_uc002ahb.1_Missense_Mutation_p.T417I|VPS13C_uc002ahc.1_Missense_Mutation_p.T374I	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	417					protein localization					ovary(2)	2						TTTAGACTGTGTTAACTTGTT	0.313		NA											11	73					0	0	0	0
MAP2K1	5604	broad.mit.edu	37	15	66727455	66727455	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:66727455G>T	uc010bhq.2	+	2	646	c.171G>T	c.(169-171)AAG>AAT	p.K57N	MAP2K1_uc010ujp.1_Missense_Mutation_p.K35N	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	57					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TTACCCAGAAGCAGAAGGTGG	0.542		NA							Cardiofaciocutaneous_syndrome				47	286					4.19e-23	4.87e-23	1	0
PLIN1	5346	broad.mit.edu	37	15	90213327	90213327	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:90213327G>A	uc010upx.1	-	5	592	c.482C>T	c.(481-483)GCG>GTG	p.A161V	PLIN1_uc002boh.2_Missense_Mutation_p.A161V	NM_001145311	NP_001138783	O60240	PLIN1_HUMAN	perilipin 1	161					triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2						AGCAAATTCCGCAGTGTCTCT	0.627		NA											9	37					0	0	0	0
OR4F15	390649	broad.mit.edu	37	15	102358822	102358822	+	Silent	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:102358822T>C	uc010uts.1	+	1	433	c.433T>C	c.(433-435)TTA>CTA	p.L145L		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTATACTTTTTAGCCACTTC	0.408		NA											36	241					0	0	0	0
TAOK2	9344	broad.mit.edu	37	16	29990752	29990752	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:29990752T>G	uc002dva.1	+	8	1361	c.578T>G	c.(577-579)GTG>GGG	p.V193G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.V193G|TAOK2_uc002dvc.1_Missense_Mutation_p.V193G|TAOK2_uc010bzm.1_Missense_Mutation_p.V193G|TAOK2_uc002dvd.1_5'Flank	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	193	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCACCCGAGGTGATCCTGGCC	0.582		NA											5	37					0	0	0	0
ITGAL	3683	broad.mit.edu	37	16	30510407	30510407	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:30510407G>A	uc002dyi.3	+	16	2021	c.1845G>A	c.(1843-1845)GTG>GTA	p.V615V	ITGAL_uc002dyj.3_Silent_p.V532V|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	615	FG-GAP 7.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CCCGGCCCGTGGTGGATATGG	0.567		NA											11	49					0	0	0	0
ABCC12	94160	broad.mit.edu	37	16	48149471	48149471	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:48149471C>T	uc002efc.1	-	13	2190	c.1844G>A	c.(1843-1845)CGC>CAC	p.R615H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	615	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GTAGACAGCGCGGGCCAGGCT	0.632		NA											21	61					0	0	0	0
FHOD1	29109	broad.mit.edu	37	16	67272317	67272317	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67272317C>T	uc002esl.2	-	4	519	c.407G>A	c.(406-408)CGC>CAC	p.R136H	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	136	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GAGGGAGCGGCGGAGCTCAGG	0.542		NA											13	39					0	0	0	0
C16orf48	84080	broad.mit.edu	37	16	67700071	67700071	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67700071G>A	uc002etw.1	-	2	466	c.183C>T	c.(181-183)CCC>CCT	p.P61P	C16orf48_uc002etv.1_5'Flank|C16orf48_uc010cem.1_Silent_p.P61P|C16orf86_uc002etx.1_5'Flank|C16orf86_uc002ety.2_5'Flank|C16orf86_uc002etz.2_5'Flank	NM_032140	NP_115516	Q9H0I2	CP048_HUMAN	hypothetical protein LOC84080	61						microtubule cytoskeleton	protein binding				0		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCGGCACCGGGACCGATGC	0.682		NA											30	110					0	0	0	0
DLG4	1742	broad.mit.edu	37	17	7099547	7099547	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7099547G>A	uc002get.3	-	13	2623	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Silent_p.F371F|DLG4_uc010cly.2_Silent_p.F428F|DLG4_uc010vto.1_Silent_p.F471F	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	431	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						ACCTGATGTAGAAACCCCTTT	0.642		NA											5	85					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578503	7578503	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7578503C>T	uc002gim.2	-	5	621	c.427G>A	c.(427-429)GTG>ATG	p.V143M	TP53_uc002gig.1_Missense_Mutation_p.V143M|TP53_uc002gih.2_Missense_Mutation_p.V143M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V11M|TP53_uc010cng.1_Missense_Mutation_p.V11M|TP53_uc002gii.1_Missense_Mutation_p.V11M|TP53_uc010cnh.1_Missense_Mutation_p.V143M|TP53_uc010cni.1_Missense_Mutation_p.V143M|TP53_uc002gij.2_Missense_Mutation_p.V143M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V50M|TP53_uc002gio.2_Missense_Mutation_p.V11M|TP53_uc010vug.1_Missense_Mutation_p.V104M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(16)|p.V143A(14)|p.0?(7)|p.V143E(4)|p.V143L(4)|p.V143V(2)|p.V143fs*27(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACAGCTGCACAGGGCAGGTC	0.587		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	47					0	0	0	0
STAC2	342667	broad.mit.edu	37	17	37368614	37368614	+	Silent	SNP	G	G	A	rs147042988		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:37368614G>A	uc002hrs.2	-	11	1386	c.1167C>T	c.(1165-1167)GAC>GAT	p.D389D	STAC2_uc010cvt.2_Silent_p.D247D	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	389					intracellular signal transduction		metal ion binding			pancreas(1)	1						GGATGAAGCCGTCAGCATCCT	0.637		NA											5	33					0	0	0	0
STAT3	6774	broad.mit.edu	37	17	40474419	40474419	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:40474419T>A	uc002hzl.1	-	21	2222	c.1982A>T	c.(1981-1983)GAT>GTT	p.D661V	STAT3_uc002hzk.1_Missense_Mutation_p.D661V|STAT3_uc002hzm.1_Missense_Mutation_p.D661V|STAT3_uc010wgh.1_Missense_Mutation_p.D563V|STAT3_uc002hzn.1_Missense_Mutation_p.D661V	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	661	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		ATTGGTAGCATCCATGATCTT	0.483		NA							Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				59	230					0	0	0	0
ITGB3	3690	broad.mit.edu	37	17	45367599	45367599	+	Missense_Mutation	SNP	G	G	T	rs150029332	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:45367599G>T	uc002ilj.2	+	8	1104	c.1084G>T	c.(1084-1086)GAT>TAT	p.D362Y	ITGB3_uc002ili.1_Missense_Mutation_p.D362Y|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	362	VWFA.|Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	TCTGTCCATGGATTCCAGCAA	0.493		NA											49	205					1.11e-26	1.3e-26	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48913362	48913362	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:48913362C>G	uc002isv.3	+	1	758	c.64C>G	c.(64-66)CTG>GTG	p.L22V	WFIKKN2_uc010dbu.2_Intron	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	22						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			gctgctgctgctgctgctact	0.602		NA											2	13					0	0	0	0
RPTOR	57521	broad.mit.edu	37	17	78899184	78899184	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:78899184G>A	uc002jyt.1	+	24	3628	c.2823G>A	c.(2821-2823)GCG>GCA	p.A941A	RPTOR_uc010wug.1_Silent_p.A783A	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	941					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CGGACGACGCGGACGATGCTG	0.572		NA											14	65					0	0	0	0
ANKRD12	23253	broad.mit.edu	37	18	9204522	9204522	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr18:9204522C>G	uc002knv.2	+	4	541	c.284C>G	c.(283-285)TCT>TGT	p.S95C	ANKRD12_uc010wzn.1_Missense_Mutation_p.S95C|ANKRD12_uc002knw.2_Intron|ANKRD12_uc002knx.2_Intron	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	95						nucleus				ovary(2)|central_nervous_system(1)	3						AGACTTATATCTTCTTACAGG	0.373		NA											41	126					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9088876	9088876	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:9088876G>A	uc002mkp.2	-	1	3143	c.2939C>T	c.(2938-2940)TCA>TTA	p.S980L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	980	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTTGTTGCTGAAGGTAACCC	0.458		NA											86	307					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132522	11132522	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:11132522C>T	uc002mqf.3	+	19	3022	c.2738C>T	c.(2737-2739)CCG>CTG	p.P913L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqg.1_Missense_Mutation_p.P913L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P913L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxt.1_Missense_Mutation_p.P133L|SMARCA4_uc002mqh.3_Missense_Mutation_p.P36L|SMARCA4_uc002mqi.1_Missense_Mutation_p.P116L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				8	44					0	0	0	0
MLL4	9757	broad.mit.edu	37	19	36214909	36214909	+	Splice_Site	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:36214909G>T	uc010eei.2	+	9	3334	c.3334_splice	c.e9+1	p.E1112_splice		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4						chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGAGAAAATGGTGCGAACTGC	0.552		NA											5	41					2.01e-06	2.19e-06	1	0
RYR1	6261	broad.mit.edu	37	19	38939326	38939326	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:38939326G>A	uc002oit.2	+	11	1125	c.995G>A	c.(994-996)GGC>GAC	p.G332D	RYR1_uc002oiu.2_Missense_Mutation_p.G332D	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	332	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GATGTGGAGGGCATGGGCCCC	0.637		NA											41	164					0	0	0	0
ZNF610	162963	broad.mit.edu	37	19	52856994	52856994	+	Silent	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:52856994G>C	uc002pyx.3	+	4	529	c.123G>C	c.(121-123)CTG>CTC	p.L41L	ZNF610_uc002pyy.3_Silent_p.L41L|ZNF610_uc002pyz.3_Silent_p.L41L|ZNF610_uc002pza.2_Silent_p.L41L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGAAATCCCTGGACCCTGGAC	0.493		NA											32	140					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54327166	54327166	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:54327166C>G	uc002qch.3	-	1	483	c.263G>C	c.(262-264)AGA>ACA	p.R88T	NLRP12_uc002qci.3_Missense_Mutation_p.R88T|NLRP12_uc002qcj.3_Missense_Mutation_p.R88T|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.R88T	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	88	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCTGTCCTCTCTCCCACAG	0.488		NA											65	224					0	0	0	0
LILRA6	79168	broad.mit.edu	37	19	54745723	54745723	+	Silent	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:54745723C>A	uc002qeu.1	-	4	511	c.387G>T	c.(385-387)CTG>CTT	p.L129L	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Silent_p.L129L|LILRA6_uc002qek.1_Silent_p.L129L|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.L129L|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.L129L|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.L129L|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.L129L|LILRA6_uc010yep.1_Silent_p.L129L|LILRA6_uc010yeq.1_Silent_p.L129L|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_5'UTR	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	129	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGGGCTGGGCAGGGCTGAGA	0.562		NA											16	412					2.46e-09	2.74e-09	1	0
PXDN	7837	broad.mit.edu	37	2	1667514	1667514	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:1667514C>T	uc002qxa.2	-	12	1494	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	PXDN_uc002qxb.1_Missense_Mutation_p.R477Q	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	477	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CAGGTGCCGCCGGTCCACGGA	0.602		NA											5	139					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80101317	80101317	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80101317C>T	uc010ysh.1	+	5	706	c.701C>T	c.(700-702)GCC>GTC	p.A234V	CTNNA2_uc010yse.1_Missense_Mutation_p.A234V|CTNNA2_uc010ysf.1_Missense_Mutation_p.A234V|CTNNA2_uc010ysg.1_Missense_Mutation_p.A234V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	234					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCAGATGTCGCCGCTACGAGA	0.582		NA											38	78					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80620359	80620359	+	Silent	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80620359T>C	uc010ysh.1	+	7	1085	c.1080T>C	c.(1078-1080)GAT>GAC	p.D360D	CTNNA2_uc010yse.1_Silent_p.D360D|CTNNA2_uc010ysf.1_Silent_p.D360D|CTNNA2_uc010ysg.1_Silent_p.D360D|CTNNA2_uc010ysi.1_5'UTR	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	360					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AAAAAGGAGATCCTCTCAACA	0.284		NA											63	118					0	0	0	0
GPR45	11250	broad.mit.edu	37	2	105858997	105858997	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:105858997C>T	uc002tco.1	+	1	798	c.682C>T	c.(682-684)CGC>TGC	p.R228C		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	228	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GAACGCCGTGCGCGTGCACAA	0.652		NA											5	150					0	0	0	0
MARCH7	64844	broad.mit.edu	37	2	160585576	160585576	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:160585576C>T	uc002uax.2	+	2	165	c.43C>T	c.(43-45)CAA>TAA	p.Q15*	MARCH7_uc010foq.2_Nonsense_Mutation_p.Q15*|MARCH7_uc010zcn.1_Nonsense_Mutation_p.Q15*	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	15	Ser-rich.						ligase activity|zinc ion binding				0						AATTTCTGTTCAACCTTCCAG	0.343		NA											34	70					0	0	0	0
SESTD1	91404	broad.mit.edu	37	2	179979882	179979882	+	Silent	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:179979882C>A	uc002uni.3	-	16	1899	c.1749G>T	c.(1747-1749)CTG>CTT	p.L583L	SESTD1_uc002unh.3_Silent_p.L86L	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	583	Spectrin 3.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATACTCTGTTCAGTCGAGGAA	0.433		NA											21	66					4.97e-08	5.49e-08	1	0
SSFA2	6744	broad.mit.edu	37	2	182767033	182767033	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:182767033A>G	uc002uoi.2	+	8	1575	c.1253A>G	c.(1252-1254)GAT>GGT	p.D418G	SSFA2_uc002uoh.2_Missense_Mutation_p.D418G|SSFA2_uc002uoj.2_Missense_Mutation_p.D418G|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.D265G|SSFA2_uc002uol.2_Missense_Mutation_p.D265G	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	418						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCCAAATTAGATAGTGATTTC	0.383		NA											15	84					0	0	0	0
BTBD3	22903	broad.mit.edu	37	20	11903288	11903288	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:11903288C>G	uc002wnz.2	+	4	902	c.543C>G	c.(541-543)ATC>ATG	p.I181M	BTBD3_uc002wny.2_Missense_Mutation_p.I120M|BTBD3_uc002woa.2_Missense_Mutation_p.I120M|BTBD3_uc010zrf.1_Missense_Mutation_p.I30M|BTBD3_uc010zrg.1_Missense_Mutation_p.I30M|BTBD3_uc010zrh.1_Missense_Mutation_p.I30M	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	181	BTB.									ovary(2)|central_nervous_system(1)	3						ACAGATATATCTATTGTGATG	0.388		NA											27	132					0	0	0	0
KIAA0406	9675	broad.mit.edu	37	20	36631033	36631033	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:36631033C>T	uc002xhl.2	-	5	2858	c.2649G>A	c.(2647-2649)CTG>CTA	p.L883L	KIAA0406_uc002xhm.2_Silent_p.L883L	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	883							binding				0		Myeloproliferative disorder(115;0.00874)				CACTGACCTTCAGGCGGATTT	0.532		NA											29	116					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	40743859	40743859	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:40743859G>A	uc002xkg.2	-	22	3263	c.3079C>T	c.(3079-3081)CGC>TGC	p.R1027C	PTPRT_uc010ggj.2_Missense_Mutation_p.R1046C|PTPRT_uc010ggi.2_Missense_Mutation_p.R230C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1027	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTGAAGGTGCGTATGACGTAT	0.458		NA											31	133					0	0	0	0
CLDN17	26285	broad.mit.edu	37	21	31538657	31538657	+	Silent	SNP	G	G	A	rs138854149		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:31538657G>A	uc011acv.1	-	1	279	c.279C>T	c.(277-279)ATC>ATT	p.I93I		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	93	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						TAAGCAGGGCGATCAAGGAGA	0.557		NA											32	105					0	0	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993723	45993723	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:45993723G>A	uc002zfk.1	+	1	118	c.88G>A	c.(88-90)GAC>AAC	p.D30N	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	30						keratin filament					0						CTGGCAGGTGGACGACTGCCC	0.682		NA											27	99					0	0	0	0
GRM7	2917	broad.mit.edu	37	3	6903213	6903213	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:6903213G>A	uc003bqm.2	+	1	412	c.138G>A	c.(136-138)GAG>GAA	p.E46E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.E46E|GRM7_uc003bql.2_Silent_p.E46E	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	46	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TCCGGATCGAGGGGGACGTCA	0.692		NA											3	12					0	0	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119084258	119084258	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:119084258C>T	uc003ecj.3	+	2	728	c.196C>T	c.(196-198)CGG>TGG	p.R66W		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	66	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						AAACATACAACGGCTAAGGTA	0.438		NA											17	100					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708596	126708596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:126708596G>A	uc003ejg.2	+	1	1095	c.1091G>A	c.(1090-1092)TGG>TAG	p.W364*		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	387	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TCCCTGCCGTGGCTGCTCAAC	0.642		NA											32	91					0	0	0	0
FAIM	55179	broad.mit.edu	37	3	138351800	138351800	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:138351800C>A	uc003esr.2	+	5	679	c.419C>A	c.(418-420)ACT>AAT	p.T140N	FAIM_uc003esp.2_Missense_Mutation_p.T174N|FAIM_uc003esq.2_Missense_Mutation_p.T162N|FAIM_uc003ess.2_Missense_Mutation_p.T140N	NM_001033032	NP_001028204	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule isoform c	140					apoptosis	cytoplasm					0						GGGACTGAAACTCACTTCAGT	0.413		NA											68	123					1.93e-29	2.28e-29	1	0
XRN1	54464	broad.mit.edu	37	3	142098954	142098954	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:142098954G>A	uc003eus.2	-	23	2752	c.2685C>T	c.(2683-2685)CCC>CCT	p.P895P	XRN1_uc010huu.2_Silent_p.P361P|XRN1_uc003eut.2_Silent_p.P895P|XRN1_uc003euu.2_Silent_p.P895P|XRN1_uc003euv.1_Silent_p.P756P	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	895					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CATCAAGATTGGGTTCACATG	0.328		NA											19	79					0	0	0	0
CHRD	8646	broad.mit.edu	37	3	184101432	184101432	+	Splice_Site	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:184101432T>C	uc003fov.2	+	12	1686	c.1440_splice	c.e12+2	p.T480_splice	CHRD_uc003fow.2_Splice_Site_p.T110_splice|CHRD_uc003fox.2_Splice_Site_p.T480_splice|CHRD_uc003foy.2_Splice_Site_p.T110_splice|CHRD_uc010hyc.2_Intron|CHRD_uc011brr.1_Splice_Site_p.T110_splice	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGACACACGGTGAGGGCTCCA	0.607		NA											10	87					0	0	0	0
CPN2	1370	broad.mit.edu	37	3	194062951	194062951	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:194062951G>C	uc003fts.2	-	2	571	c.481C>G	c.(481-483)CCC>GCC	p.P161A		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	161	LRR 3.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AGCCTCCTGGGCAGGGCCTGG	0.637		NA											11	93					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111430849	111430849	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr4:111430849G>A	uc003iab.3	+	5	1422	c.1080G>A	c.(1078-1080)GAG>GAA	p.E360E		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	360	Substrate binding (By similarity).|Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GTGCCATGGAGAACTGGGGAC	0.443		NA											25	132					0	0	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741347	140741347	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:140741347C>T	uc003ljs.1	+	1	1645	c.1645C>T	c.(1645-1647)CGC>TGC	p.R549C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.R549C|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	549	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGAGCCTGCGCGTGTTAGT	0.697		NA											21	103					0	0	0	0
HAVCR1	26762	broad.mit.edu	37	5	156456763	156456763	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:156456763C>T	uc010jij.1	-	9	1261	c.1076G>A	c.(1075-1077)AGT>AAT	p.S359N	HAVCR1_uc011ddl.1_Missense_Mutation_p.V179I|HAVCR1_uc003lwi.2_Missense_Mutation_p.S359N	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	354	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCATAAAGACTATTCTCAAT	0.408		NA											15	61					0	0	0	0
GABRG2	2566	broad.mit.edu	37	5	161524781	161524781	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:161524781C>T	uc003lyz.3	+	4	823	c.465C>T	c.(463-465)TCC>TCT	p.S155S	GABRG2_uc010jjc.2_Silent_p.S155S|GABRG2_uc003lyy.3_Silent_p.S155S|GABRG2_uc011dej.1_Silent_p.S60S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	155	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TCAGAAATTCCAAAAAAGCTG	0.428		NA											38	165					0	0	0	0
RPL26L1	51121	broad.mit.edu	37	5	172386987	172386987	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:172386987G>C	uc003mcc.2	+	2	153	c.111G>C	c.(109-111)GAG>GAC	p.E37D	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	37					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCCAAGGAGCTGCGGCAGA	0.602		NA											37	180					0	0	0	0
RNF44	22838	broad.mit.edu	37	5	175958006	175958006	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:175958006G>C	uc003mek.1	-	5	1007	c.482C>G	c.(481-483)ACC>AGC	p.T161S	RNF44_uc011dfo.1_Missense_Mutation_p.T69S|RNF44_uc003mel.1_5'Flank	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	161	Pro-rich.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCTGCATGGTGCACGCCTG	0.667		NA											7	20					0	0	0	0
GPLD1	2822	broad.mit.edu	37	6	24437400	24437400	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:24437400C>T	uc003ned.1	-	21	2249	c.2138G>A	c.(2137-2139)CGC>CAC	p.R713H		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	713	FG-GAP 6.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GGAGAAGCGGCGGTCTCCGCT	0.562		NA											22	116					0	0	0	0
MAS1L	116511	broad.mit.edu	37	6	29455445	29455445	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:29455445C>A	uc011dlq.1	-	1	235	c.235G>T	c.(235-237)GCC>TCC	p.A79S		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	79	Helical; Name=1; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GCCTTGGGGGCAATGATATTC	0.512		NA											24	67					3.08e-08	3.42e-08	1	0
TULP1	7287	broad.mit.edu	37	6	35467758	35467758	+	Missense_Mutation	SNP	G	G	A	rs138772407	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:35467758G>A	uc003okv.3	-	14	1507	c.1495C>T	c.(1495-1497)CCC>TCC	p.P499S	TEAD3_uc003oku.3_5'Flank|TEAD3_uc010jvx.2_5'Flank|TULP1_uc003okw.3_Missense_Mutation_p.P446S	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	499					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGGTACTCACGGTCATCAGCG	0.587		NA											71	107					0	0	0	0
DST	667	broad.mit.edu	37	6	56489977	56489977	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:56489977G>T	uc003pdf.2	-	34	4737	c.4709C>A	c.(4708-4710)TCA>TAA	p.S1570*	DST_uc003pcz.3_Nonsense_Mutation_p.S1392*|DST_uc011dxj.1_Nonsense_Mutation_p.S1421*|DST_uc011dxk.1_Nonsense_Mutation_p.S1432*|DST_uc003pcy.3_Nonsense_Mutation_p.S1066*|DST_uc003pdb.2_Nonsense_Mutation_p.S1066*|DST_uc003pdc.3_Nonsense_Mutation_p.S1066*|DST_uc003pdd.3_Nonsense_Mutation_p.S1066*	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1392					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGATCTGCTGAACTCTGCAT	0.353		NA											63	273					4.6e-24	5.38e-24	1	0
PRDM1	639	broad.mit.edu	37	6	106552717	106552717	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:106552717C>T	uc003prd.2	+	5	916	c.682C>T	c.(682-684)CTA>TTA	p.L228L	PRDM1_uc003pre.2_Silent_p.L94L	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	228					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACAGAGCAGTCTAAAGCAACC	0.448		NA	D|N|Mis|F|S		DLBCL								70	332					0	0	0	0
ARID1B	57492	broad.mit.edu	37	6	157528080	157528080	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:157528080G>A	uc003qqn.2	+	20	5903	c.5751G>A	c.(5749-5751)GCG>GCA	p.A1917A	ARID1B_uc003qqo.2_Silent_p.A1877A|ARID1B_uc003qqp.2_Silent_p.A1864A	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1922					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTACCATCGCGCACTGGCAGG	0.537		NA											37	147					0	0	0	0
COBL	23242	broad.mit.edu	37	7	51203960	51203960	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:51203960C>T	uc003tpr.3	-	6	1037	c.852G>A	c.(850-852)TCG>TCA	p.S284S	COBL_uc003tps.2_Silent_p.S284S|COBL_uc011kcl.1_Silent_p.S284S|COBL_uc010kzc.2_Silent_p.S284S|COBL_uc003tpt.2_Silent_p.S284S|COBL_uc003tpp.3_Silent_p.S13S|COBL_uc003tpq.3_Silent_p.S225S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	284										skin(3)|ovary(2)	5	Glioma(55;0.08)					TGCTGCCCAGCGAGAGGGATG	0.577		NA											14	69					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100696279	100696279	+	Silent	SNP	G	G	A	rs146965923		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:100696279G>A	uc003uxp.1	+	10	13169	c.13116G>A	c.(13114-13116)ACG>ACA	p.T4372T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4372	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCGTGACCACGGAAACTCACT	0.602		NA											19	102					0	0	0	0
SLC26A4	5172	broad.mit.edu	37	7	107330644	107330644	+	Missense_Mutation	SNP	C	C	T	rs147952620	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:107330644C>T	uc003vep.2	+	10	1449	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	SLC26A4_uc011kmb.1_5'Flank|SLC26A4_uc011kmc.1_5'Flank	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	409	Extracellular (Potential).		R -> H (in PDS).|R -> P (in DFNB4).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TGCTCTTTCCCGCACGGCCGT	0.493		NA							Pendred_syndrome				42	145					0	0	0	0
GCC1	79571	broad.mit.edu	37	7	127222240	127222240	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:127222240T>C	uc003vma.2	-	2	2574	c.2156A>G	c.(2155-2157)AAT>AGT	p.N719S		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	719	Potential.|GRIP.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GTACTCCAGATTGGCTCCCTC	0.567		NA											43	173					0	0	0	0
SSPO	23145	broad.mit.edu	37	7	149510810	149510810	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:149510810C>T	uc010lpk.2	+	72	10095	c.10095C>T	c.(10093-10095)TGC>TGT	p.C3365C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3365	TIL 5.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGGGTCACTGCAGCTGCCTGG	0.697		NA											13	39					0	0	0	0
USP17L2	377630	broad.mit.edu	37	8	11996046	11996046	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:11996046G>A	uc003wvc.1	-	1	224	c.224C>T	c.(223-225)CCT>CTT	p.P75L	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	75					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						CACCGCAGCAGGTCTCCTGCT	0.572		NA											15	346					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104955091	104955091	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:104955091C>A	uc003yls.2	+	12	2213	c.1972C>A	c.(1972-1974)CAC>AAC	p.H658N	RIMS2_uc003ylp.2_Missense_Mutation_p.H880N|RIMS2_uc003ylw.2_Missense_Mutation_p.H672N|RIMS2_uc003ylq.2_Missense_Mutation_p.H672N|RIMS2_uc003ylr.2_Missense_Mutation_p.H719N|RIMS2_uc003ylt.2_Missense_Mutation_p.H265N	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	942					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.Y658S(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCCACTTCCCCACCCTTCTCC	0.388		NA								HNSCC(12;0.0054)			22	130					5.45e-15	6.19e-15	1	0
FAM83H	286077	broad.mit.edu	37	8	144810795	144810795	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:144810795G>A	uc003yzk.2	-	5	905	c.836C>T	c.(835-837)GCG>GTG	p.A279V	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	279					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCGGACTGCGCGAAGAGGAT	0.672		NA											4	44					0	0	0	0
SHB	6461	broad.mit.edu	37	9	37919970	37919970	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:37919970C>T	uc004aax.2	-	6	1946	c.1378G>A	c.(1378-1380)GCC>ACC	p.A460T		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	460	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TTGGTTTTGGCCAGTTTCATG	0.502		NA											5	161					0	0	0	0
GADD45G	10912	broad.mit.edu	37	9	92220945	92220945	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:92220945A>C	uc004aqq.2	+	4	541	c.431A>C	c.(430-432)GAG>GCG	p.E144A	GADD45G_uc004aqr.2_Missense_Mutation_p.E126A	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	144					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						TTTTGCGAGGAGAGCCGCAGC	0.682		NA											4	30					0	0	0	0
KIAA1529	57653	broad.mit.edu	37	9	100075586	100075586	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100075586G>A	uc011lut.1	+	17	1740	c.967G>A	c.(967-969)GCT>ACT	p.A323T	KIAA1529_uc004axe.1_Missense_Mutation_p.A323T|KIAA1529_uc004axg.1_Missense_Mutation_p.A184T|KIAA1529_uc011lus.1_Missense_Mutation_p.A184T|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.A184T|KIAA1529_uc011luv.1_Missense_Mutation_p.A184T	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CTACGAGAGCGCTCTGGCCAG	0.542		NA											18	135					0	0	0	0
NCBP1	4686	broad.mit.edu	37	9	100424349	100424349	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100424349G>A	uc004axq.2	+	17	2085	c.1626G>A	c.(1624-1626)TTG>TTA	p.L542L		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	542					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TTAACCCATTGAAAATAGAAG	0.373		NA											12	96					0	0	0	0
KIAA1210	57481	broad.mit.edu	37	X	118217058	118217058	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chrX:118217058T>C	uc004era.3	-	13	4874	c.4874A>G	c.(4873-4875)CAA>CGA	p.Q1625R		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1625										ovary(4)|skin(1)	5						CTTTTTAGGTTGGTTTTCATT	0.388		NA											34	61					0	0	0	0
CTCF	10664	broad.mit.edu	37	16	67645241	67645242	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67645241_67645242insG	uc002etl.2	+	3	796_797	c.506_507insG	c.(505-507)GTGfs	p.V169fs	CTCF_uc010cek.2_Intron	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	169					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GTGGTTAAAGTGGGGGCCAATG	0.505		NA											19	122	---	---	---	---	NA	NA	NA	NA
CASP8	841	broad.mit.edu	37	2	202149679	202149688	+	Frame_Shift_Del	DEL	CTCTCCCATG	CTCTCCCATG	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:202149679_202149688delCTCTCCCATG	uc002uxr.1	+	9	1152_1161	c.943_952delCTCTCCCATG	c.(943-954)CTCTCCCATGGAfs	p.L315fs	CASP8_uc002uxp.1_Frame_Shift_Del_p.L332fs|CASP8_uc002uxq.1_Frame_Shift_Del_p.L300fs|CASP8_uc002uxt.1_Frame_Shift_Del_p.L374fs|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Frame_Shift_Del_p.L300fs|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Frame_Shift_Del_p.L231fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	315_318					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTGCTGTATCCTCTCCCATGGAGACAAGGG	0.486		NA								HNSCC(4;0.00038)			41	199	---	---	---	---	NA	NA	NA	NA
NPPC	4880	broad.mit.edu	37	2	232790411	232790412	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:232790411_232790412insG	uc002vsl.1	-	2	104_105	c.104_105insC	c.(103-105)CCGfs	p.P35fs		NM_024409	NP_077720	P23582	ANFC_HUMAN	natriuretic peptide precursor C precursor	35					cGMP biosynthetic process|growth plate cartilage chondrocyte differentiation|growth plate cartilage chondrocyte proliferation|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vasoconstriction		hormone activity				0		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;9.35e-14)|BRCA - Breast invasive adenocarcinoma(100;0.00119)|LUSC - Lung squamous cell carcinoma(224;0.00746)|Lung(119;0.00834)		CCTCTGCCGGCGGGGTTCGCGG	0.743		NA											7	8	---	---	---	---	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113662425	113662425	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:113662425delT	uc003ynu.2	-	19	3317	c.3158delA	c.(3157-3159)AACfs	p.N1053fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.N325fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.N1013fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.N949fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1053	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCACCAGTGGTTTTTTTCGCA	0.378		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	318	---	---	---	---	NA	NA	NA	NA
