Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
APITD1	378708	broad.mit.edu	37	1	10494743	10494743	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:10494743G>A	uc001are.2	+	3	621	c.205G>A	c.(205-207)GCA>ACA	p.A69T	APITD1_uc001arf.2_Missense_Mutation_p.A69T|APITD1_uc001arg.2_3'UTR|APITD1_uc001arh.2_Missense_Mutation_p.A30T	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	69					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TGAAATGTTTGCAAGGTGGGT	0.418		NA											8	162					0	0	0	0
EIF4G3	8672	broad.mit.edu	37	1	21220080	21220080	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:21220080G>C	uc001bec.2	-	13	2271	c.2015C>G	c.(2014-2016)CCT>CGT	p.P672R	EIF4G3_uc010odi.1_Missense_Mutation_p.P276R|EIF4G3_uc010odj.1_Missense_Mutation_p.P671R|EIF4G3_uc009vpz.2_Missense_Mutation_p.P392R|EIF4G3_uc001bed.2_Missense_Mutation_p.P672R|EIF4G3_uc001bef.2_Missense_Mutation_p.P671R|EIF4G3_uc001bee.2_Missense_Mutation_p.P678R	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	672					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGGTCCTCGAGGCAAAATTCG	0.463		NA											46	83					0	0	0	0
PPP1R8	5511	broad.mit.edu	37	1	28167531	28167531	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:28167531G>A	uc001bov.1	+	4	332	c.278G>A	c.(277-279)GGC>GAC	p.G93D	PPP1R8_uc001bow.1_5'UTR|PPP1R8_uc001box.1_Intron|PPP1R8_uc009vtc.1_RNA|PPP1R8_uc009vtd.1_Intron	NM_014110	NP_054829	Q12972	PP1R8_HUMAN	protein phosphatase 1 regulatory inhibitor	93	FHA.|Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding				0		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCACACGGCACTTTCTTG	0.468		NA											5	250					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046335	42046335	+	Silent	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:42046335G>A	uc001cgz.3	-	4	5347	c.4134C>T	c.(4132-4134)CCC>CCT	p.P1378P	HIVEP3_uc001cha.3_Silent_p.P1378P|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1378					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CAGAAGGGCCGGGCCCAACCT	0.527		NA											105	134					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169391468	169391468	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:169391468A>T	uc001gga.1	-	3	369	c.201T>A	c.(199-201)GAT>GAA	p.D67E	C1orf114_uc001gfz.1_Missense_Mutation_p.D67E|C1orf114_uc009wvq.1_Missense_Mutation_p.D67E|C1orf114_uc001ggb.2_Missense_Mutation_p.D67E|C1orf114_uc001ggc.1_Missense_Mutation_p.D67E	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	67											0	all_hematologic(923;0.208)					ATTTGTCAGGATCAGAATGCC	0.383		NA											45	83					0	0	0	0
C1orf49	84066	broad.mit.edu	37	1	178491563	178491563	+	Silent	SNP	T	T	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:178491563T>A	uc001glt.1	+	9	802	c.690T>A	c.(688-690)ACT>ACA	p.T230T	C1orf49_uc001glu.1_3'UTR|C1orf49_uc001glv.1_Intron|C1orf49_uc001glw.1_Intron	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	230						microtubule cytoskeleton					0						agtcccagactgagggaaggt	0.04		NA											10	13					0	0	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406952	75406952	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr10:75406952A>G	uc001jut.3	-	4	2610	c.2458T>C	c.(2458-2460)TTT>CTT	p.F820L	SYNPO2L_uc001jus.3_Missense_Mutation_p.F596L	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	820	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					TGGGGGAAAAAGGGAGAGAGC	0.577		NA											3	250					0	0	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7618879	7618879	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:7618879A>G	uc001mfj.3	+	5	849	c.461A>G	c.(460-462)AAT>AGT	p.N154S	PPFIBP2_uc010rbb.1_Missense_Mutation_p.N77S|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.N77S|PPFIBP2_uc010rbd.1_5'UTR|PPFIBP2_uc010rbe.1_Missense_Mutation_p.N42S	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	154	Potential.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GTGAAACTCAATGCTGCTGAA	0.547		NA											16	20					0	0	0	0
TMEM132A	54972	broad.mit.edu	37	11	60696185	60696185	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:60696185T>A	uc001nqj.2	+	4	812	c.619T>A	c.(619-621)TAC>AAC	p.Y207N	TMEM132A_uc001nqi.2_Missense_Mutation_p.Y207N|TMEM132A_uc001nqk.2_Missense_Mutation_p.Y220N|TMEM132A_uc001nql.1_Missense_Mutation_p.Y220N	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	207	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CGAGCTGGCCTACACGCTTGA	0.692		NA											28	38					0	0	0	0
DRD2	1813	broad.mit.edu	37	11	113283362	113283362	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:113283362G>A	uc001pnz.2	-	6	1375	c.1054C>T	c.(1054-1056)CGG>TGG	p.R352W	DRD2_uc010rwv.1_Missense_Mutation_p.R351W|DRD2_uc001poa.3_Missense_Mutation_p.R352W|DRD2_uc001pob.3_Missense_Mutation_p.R323W	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	352	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGGGAGGTCCGGGTTTTGCCA	0.567		NA											52	41					0	0	0	0
GRIK4	2900	broad.mit.edu	37	11	120732824	120732824	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:120732824C>T	uc001pxn.2	+	9	1188	c.901C>T	c.(901-903)CCT>TCT	p.P301S	GRIK4_uc009zav.1_Missense_Mutation_p.P301S|GRIK4_uc009zaw.1_Missense_Mutation_p.P301S|GRIK4_uc009zax.1_Missense_Mutation_p.P301S	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	301	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CTTCACTGGGCCTGCGGTAAG	0.562		NA											142	232					0	0	0	0
OPCML	4978	broad.mit.edu	37	11	132527003	132527003	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:132527003G>A	uc001qgs.2	-	2	429	c.379C>T	c.(379-381)CGG>TGG	p.R127W	OPCML_uc001qgu.2_Missense_Mutation_p.R120W|OPCML_uc010sck.1_Missense_Mutation_p.R127W|OPCML_uc001qgt.2_Missense_Mutation_p.R127W|OPCML_uc010scl.1_Missense_Mutation_p.R86W	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	127					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		AGGTGAACCCGGGACGTTTTG	0.502		NA											31	87					0	0	0	0
KRT2	3849	broad.mit.edu	37	12	53039156	53039156	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr12:53039156C>A	uc001sat.2	-	9	1600	c.1567G>T	c.(1567-1569)GGT>TGT	p.G523C		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	523	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GACCCTCTACCTCCAGAACCT	0.552		NA											88	148					7.54e-32	8.8e-32	1	0
HAL	3034	broad.mit.edu	37	12	96379739	96379739	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr12:96379739G>A	uc001tem.1	-	14	1450	c.1153C>T	c.(1153-1155)CAC>TAC	p.H385Y	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.H177Y|HAL_uc010sux.1_Missense_Mutation_p.H385Y	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	385					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CAGAACCTGTGACTCTCTGTG	0.418		NA											33	40					0	0	0	0
SIAH3	283514	broad.mit.edu	37	13	46357874	46357874	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr13:46357874C>T	uc001vap.2	-	2	536	c.454G>A	c.(454-456)GCG>ACG	p.A152T		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	152					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						TCAGCCGGCGCGGGGAGGTGC	0.617		NA											27	19					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64493344	64493344	+	Silent	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr14:64493344C>T	uc001xgm.2	+	42	6530	c.6300C>T	c.(6298-6300)ATC>ATT	p.I2100I	SYNE2_uc001xgl.2_Silent_p.I2100I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2100	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAGAGACCATCATGAAGCAGG	0.448		NA											17	9					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414123	105414123	+	Silent	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr14:105414123A>G	uc010axc.1	-	7	7785	c.7665T>C	c.(7663-7665)CCT>CCC	p.P2555P	AHNAK2_uc001ypx.2_Silent_p.P2455P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2555						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTCCGGCACAGGGCCCTCTG	0.627		NA											4	220					0	0	0	0
ERN2	10595	broad.mit.edu	37	16	23713534	23713534	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:23713534C>T	uc002dma.3	-	11	1455	c.1286G>A	c.(1285-1287)GGG>GAG	p.G429E	ERN2_uc010bxp.2_Missense_Mutation_p.G429E|ERN2_uc010bxq.1_Missense_Mutation_p.G237E	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	381	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGTTCCACTCCCCAGGGTGGG	0.617		NA											112	190					0	0	0	0
CYLD	1540	broad.mit.edu	37	16	50820854	50820854	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:50820854A>T	uc002egp.1	+	13	2453	c.2038A>T	c.(2038-2040)AAA>TAA	p.K680*	CYLD_uc010cbs.1_Nonsense_Mutation_p.K677*|CYLD_uc002egq.1_Nonsense_Mutation_p.K677*|CYLD_uc002egr.1_Nonsense_Mutation_p.K677*|CYLD_uc002egs.1_Nonsense_Mutation_p.K677*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	680					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				CTCTGAAGAAAAAGGTGACCA	0.358		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				37	26					0	0	0	0
IRX6	79190	broad.mit.edu	37	16	55361590	55361590	+	Missense_Mutation	SNP	G	G	A	rs139251893	by1000genomes	TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:55361590G>A	uc002ehy.2	+	4	1039	c.506G>A	c.(505-507)CGC>CAC	p.R169H	IRX6_uc002ehx.2_Missense_Mutation_p.R169H|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	169	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AACGAGCACCGCAAAAACCCC	0.612		NA											3	56					0	0	0	0
CDH3	1001	broad.mit.edu	37	16	68729271	68729271	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:68729271G>A	uc002ewf.2	+	14	3248	c.2116G>A	c.(2116-2118)GGT>AGT	p.G706S	CDH3_uc010vli.1_Missense_Mutation_p.G651S	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CGAAGAGGGGGGTGGCGAAGA	0.587		NA											14	6					0	0	0	0
SHBG	6462	broad.mit.edu	37	17	7533791	7533791	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr17:7533791G>A	uc002gie.2	+	2	207	c.169G>A	c.(169-171)GCT>ACT	p.A57T	SHBG_uc010cmo.2_5'UTR|SHBG_uc010cmp.2_5'UTR|SHBG_uc010cmq.2_5'UTR|SHBG_uc010cmr.2_5'UTR|SHBG_uc010cms.2_5'UTR|SHBG_uc010cmt.2_5'UTR|SHBG_uc010cmu.2_5'UTR|SAT2_uc002gib.1_5'Flank|SAT2_uc002gic.2_5'Flank|SHBG_uc010cmz.2_5'UTR|SHBG_uc010cmv.2_5'UTR|SHBG_uc010cmw.2_5'UTR|SHBG_uc010cmx.2_5'UTR|SHBG_uc010cmy.2_5'UTR|SHBG_uc002gid.3_5'UTR|SHBG_uc010cnd.2_Missense_Mutation_p.A57T|SHBG_uc010cna.2_Missense_Mutation_p.A57T|SHBG_uc010vue.1_Missense_Mutation_p.A57T|SHBG_uc010vuf.1_Missense_Mutation_p.A57T|SHBG_uc010cnb.2_Missense_Mutation_p.A57T|SHBG_uc010cnc.2_Missense_Mutation_p.A57T	NM_001040	NP_001031	P04278	SHBG_HUMAN	sex hormone-binding globulin isoform 1	57	Laminin G-like 1.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.?(1)			0		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	AGAGCCTATCGCTGTCATGAC	0.537		NA											58	108					0	0	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79954516	79954516	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr17:79954516G>C	uc002kcx.2	+	7	824	c.727G>C	c.(727-729)GTT>CTT	p.V243L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.V243L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.V243L|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Missense_Mutation_p.V166L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.V166L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	243							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TGCCCCCTTTGTTCCTTTCTC	0.657		NA	T	TFE3	alveolar soft part sarcoma								20	42					0	0	0	0
CHMP1B	57132	broad.mit.edu	37	18	11851812	11851812	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:11851812C>T	uc002kqe.2	+	1	424	c.302C>T	c.(301-303)GCG>GTG	p.A101V	GNAL_uc002kqc.2_Intron|GNAL_uc010dkz.2_Intron|GNAL_uc002kqd.2_Intron	NM_020412	NP_065145	Q7LBR1	CHM1B_HUMAN	chromatin modifying protein 1B	101					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding				0						TCGATGGATGCGACATTGAAG	0.532		NA											4	194					0	0	0	0
C18orf1	753	broad.mit.edu	37	18	13645458	13645458	+	Silent	SNP	C	C	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:13645458C>G	uc002ksa.2	+	7	1391	c.723C>G	c.(721-723)ACC>ACG	p.T241T	C18orf1_uc002ksb.2_Silent_p.T223T|C18orf1_uc002kse.2_Silent_p.T204T|C18orf1_uc002ksf.2_Silent_p.T186T|C18orf1_uc002ksg.1_Silent_p.T164T|C18orf1_uc002ksh.1_Silent_p.T183T|C18orf1_uc002ksi.1_Silent_p.T165T	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	241	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GTGCAAGCACCTGCAGCAGTA	0.582		NA											67	86					0	0	0	0
ZNF516	9658	broad.mit.edu	37	18	74091731	74091731	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:74091731C>T	uc010dqx.1	-	3	2574	c.2339G>A	c.(2338-2340)CGC>CAC	p.R780H	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	780	C2H2-type 9; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GTGCCAGATGCGTTTGTGCAT	0.572		NA											13	30					0	0	0	0
GNA15	2769	broad.mit.edu	37	19	3148739	3148739	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:3148739G>A	uc002lxf.2	+	2	554	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	GNA15_uc010xhf.1_Missense_Mutation_p.R99Q	NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	99					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		GCCATGGAGCGGCTGCAGATT	0.692		NA											7	1					0	0	0	0
DENND1C	79958	broad.mit.edu	37	19	6477435	6477435	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:6477435A>G	uc002mfe.2	-	7	493	c.401T>C	c.(400-402)TTT>TCT	p.F134S	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.F90S	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	134	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GGACTGCTGAAACAGATTTTG	0.627		NA											19	19					0	0	0	0
ZNF429	353088	broad.mit.edu	37	19	21719158	21719158	+	Silent	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:21719158G>A	uc002nqd.1	+	4	440	c.303G>A	c.(301-303)AGG>AGA	p.R101R	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGACACTGAGGAGATATGATA	0.328		NA											5	45					0	0	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73316366	73316366	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:73316366C>T	uc002siu.3	-	2	750	c.509G>A	c.(508-510)CGC>CAC	p.R170H	RAB11FIP5_uc002sit.3_Missense_Mutation_p.R92H	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	170					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CAGGTTGTTGCGCGTGAACTG	0.532		NA											6	586					0	0	0	0
SEMA4F	10505	broad.mit.edu	37	2	74883774	74883774	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:74883774G>A	uc002sna.1	+	2	370	c.259G>A	c.(259-261)GCT>ACT	p.A87T	SEMA4F_uc010ysb.1_Missense_Mutation_p.A87T|SEMA4F_uc010ffq.1_Missense_Mutation_p.A87T|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.A87T	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	87	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CACCATCTTCGCTTTATCCCT	0.527		NA											68	131					0	0	0	0
C2orf68	388969	broad.mit.edu	37	2	85836569	85836569	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:85836569T>A	uc002sqc.2	-	3	439	c.367A>T	c.(367-369)ATC>TTC	p.I123F	USP39_uc002sqb.2_Intron|USP39_uc010ysu.1_5'Flank|USP39_uc010ysv.1_5'Flank	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	123										central_nervous_system(1)	1						TGATAGACGATAACTGATGTG	0.542		NA											170	299					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179568957	179568957	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:179568957A>G	uc010zfg.1	-	103	26632	c.26408T>C	c.(26407-26409)ATT>ACT	p.I8803T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I5464T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9730							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATCTGCAATGGTCAATTT	0.413		NA											91	181					0	0	0	0
MARS2	92935	broad.mit.edu	37	2	198571571	198571571	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:198571571G>A	uc002uuq.2	+	1	1485	c.1442G>A	c.(1441-1443)CGG>CAG	p.R481Q	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	481					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	AGCTGTGTCCGGCAAACTAAT	0.542		NA											4	261					0	0	0	0
AGFG1	3267	broad.mit.edu	37	2	228416677	228416677	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:228416677G>A	uc002vpc.2	+	11	1631	c.1381G>A	c.(1381-1383)GCA>ACA	p.A461T	AGFG1_uc002vpd.2_Missense_Mutation_p.A485T|AGFG1_uc002vpe.2_Missense_Mutation_p.A461T|AGFG1_uc002vpf.2_Missense_Mutation_p.A421T	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	461					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TCTGTCAGCGGCAACCTTTGG	0.458		NA											4	231					0	0	0	0
KCNK15	60598	broad.mit.edu	37	20	43378887	43378887	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr20:43378887C>T	uc002xmr.2	+	2	465	c.401C>T	c.(400-402)GCG>GTG	p.A134V		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	134	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				CGGCTGAACGCGGTGGTGCGG	0.682		NA											3	18					0	0	0	0
MYH9	4627	broad.mit.edu	37	22	36685234	36685234	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr22:36685234A>G	uc003apg.2	-	32	4685	c.4454T>C	c.(4453-4455)CTG>CCG	p.L1485P		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1485	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GGCTTCCTCCAGGGCCCGGGC	0.627		NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				24	47					0	0	0	0
PHF5A	84844	broad.mit.edu	37	22	41863565	41863565	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr22:41863565G>A	uc003bab.2	-	3	181	c.130C>T	c.(130-132)CGC>TGC	p.R44C	ACO2_uc003bac.2_5'Flank|ACO2_uc003bad.2_5'Flank	NM_032758	NP_116147	Q7RTV0	PHF5A_HUMAN	PHD-finger 5A	44					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent	nuclear speck|U12-type spliceosomal complex|U2 snRNP	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCACATATGCGCACCAGAGTG	0.493		NA											43	60					0	0	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432939	111432939	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:111432939G>T	uc003dya.2	+	3	1416	c.830G>T	c.(829-831)GGC>GTC	p.G277V	PLCXD2_uc003dyb.2_Missense_Mutation_p.G277V|PLCXD2_uc003dxz.2_Missense_Mutation_p.G277V	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	277					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ATTGCCCGGGGCTTGGTTGGG	0.502		NA											6	173					3.6e-05	4.12e-05	1	0
MYLK	4638	broad.mit.edu	37	3	123385193	123385193	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:123385193G>A	uc003ego.2	-	22	3986	c.3704C>T	c.(3703-3705)GCA>GTA	p.A1235V	MYLK_uc010hrr.2_5'Flank|MYLK_uc011bjv.1_Missense_Mutation_p.A35V|MYLK_uc011bjw.1_Missense_Mutation_p.A1235V|MYLK_uc003egp.2_Missense_Mutation_p.A1166V|MYLK_uc003egq.2_Missense_Mutation_p.A1235V|MYLK_uc003egr.2_Missense_Mutation_p.A1166V|MYLK_uc003egs.2_Missense_Mutation_p.A1059V	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1235	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGGGGCATTGCTGAGGGAGG	0.557		NA											42	166					0	0	0	0
SMC4	10051	broad.mit.edu	37	3	160150245	160150245	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:160150245G>A	uc003fdh.2	+	22	3585	c.3472G>A	c.(3472-3474)GAC>AAC	p.D1158N	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D1133N|SMC4_uc003fdj.2_Missense_Mutation_p.D1158N|SMC4_uc010hwd.2_Missense_Mutation_p.D1100N|SMC4_uc003fdl.2_Missense_Mutation_p.D861N	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1158					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTTGGGAGGGGACGCCGAACT	0.363		NA											8	89					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505835	195505835	+	Missense_Mutation	SNP	C	C	T	rs58500707	by1000genomes	TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:195505835C>T	uc011bto.1	-	3	12692	c.12232G>A	c.(12232-12234)GCC>ACC	p.A4078T	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAGGGGTGGCGTGACCTGTG	0.597		NA											8	16					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505838	195505838	+	Missense_Mutation	SNP	G	G	C	rs59101491		TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:195505838G>C	uc011bto.1	-	3	12689	c.12229C>G	c.(12229-12231)CAC>GAC	p.H4077D	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGCGTGACCTGTGGAT	0.597		NA											8	16					0	0	0	0
FRYL	285527	broad.mit.edu	37	4	48529997	48529997	+	Silent	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr4:48529997C>T	uc003gyh.1	-	52	7736	c.7131G>A	c.(7129-7131)AAG>AAA	p.K2377K	FRYL_uc003gyg.1_Silent_p.K1073K|FRYL_uc003gyi.1_Silent_p.K1265K|FRYL_uc003gyj.1_Silent_p.K672K	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2377					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTGATGGGTTCTTTGGGAGGC	0.373		NA											5	152					0	0	0	0
UGT2B10	7365	broad.mit.edu	37	4	69870669	69870669	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr4:69870669C>A	uc011cao.1	-	9	1517	c.1381G>T	c.(1381-1383)GCT>TCT	p.A461S	UGT2B10_uc011can.1_Missense_Mutation_p.A377S			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	498	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCCACACAGGCCAGCAGGAAC	0.448		NA											11	205					5.51e-06	6.34e-06	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480302	140480302	+	Silent	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr5:140480302G>A	uc003lio.2	+	1	69	c.69G>A	c.(67-69)GGG>GGA	p.G23G	uc003lin.2_RNA	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	23					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTGGGAGGGTCTCTGGCTG	0.498		NA											27	75					0	0	0	0
SLC26A2	1836	broad.mit.edu	37	5	149357868	149357868	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr5:149357868C>T	uc003lrh.2	+	2	921	c.653C>T	c.(652-654)GCA>GTA	p.A218V		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	218	Extracellular (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGTTGCTATGCAATTATGGTT	0.363		NA											50	134					0	0	0	0
OR2W1	26692	broad.mit.edu	37	6	29012436	29012436	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:29012436T>C	uc003nlw.2	-	1	517	c.517A>G	c.(517-519)ATT>GTT	p.I173V		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGATCCAGAATGTTGTTTCCA	0.378		NA											62	105					0	0	0	0
NEU1	4758	broad.mit.edu	37	6	31828219	31828219	+	Silent	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:31828219G>A	uc003nxq.3	-	4	951	c.795C>T	c.(793-795)TGC>TGT	p.C265C	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Silent_p.C96C|NEU1_uc003nxs.3_Silent_p.C265C	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	265						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	TCCTGACCTGGCATTCATCAG	0.557		NA											4	163					0	0	0	0
KCNK5	8645	broad.mit.edu	37	6	39159524	39159524	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:39159524G>T	uc003oon.2	-	5	1006	c.642C>A	c.(640-642)AAC>AAA	p.N214K		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	214					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TGGCGCTGGGGTTCACACCTG	0.587		NA											65	121					4.39e-42	5.15e-42	1	0
CHPF2	54480	broad.mit.edu	37	7	150934838	150934838	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr7:150934838C>T	uc003wjr.1	+	4	2903	c.1390C>T	c.(1390-1392)CGC>TGC	p.R464C	CHPF2_uc003wjq.1_Missense_Mutation_p.R456C|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	464	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						GGCCCTGGCTCGCAGGGTCAG	0.652		NA											27	58					0	0	0	0
FAM86B2	653333	broad.mit.edu	37	8	12285220	12285220	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:12285220C>T	uc003wvt.3	-	7	838	c.838G>A	c.(838-840)GTG>ATG	p.V280M	FAM66D_uc011kxp.1_Intron|uc003wvm.1_Intron|uc011kxs.1_5'Flank|uc003wvp.1_5'Flank|FAM86B2_uc003wvq.3_RNA|FAM86B2_uc003wvr.3_Missense_Mutation_p.V103M|FAM86B2_uc003wvs.3_Missense_Mutation_p.V180M|FAM86B2_uc010lsn.2_RNA|FAM86B2_uc003wvu.3_Missense_Mutation_p.V89M|FAM86B2_uc010lso.2_RNA|FAM86B2_uc011kxt.1_Missense_Mutation_p.V52M|FAM86B2_uc011kxu.1_RNA|FAM86B2_uc010lsl.2_RNA	NM_001137610	NP_001131082	P0C5J1	F86B2_HUMAN	hypothetical protein LOC653333	280											0						GTAAAGGCCACGTAGACCTCA	0.652		NA											7	41					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55534066	55534066	+	Silent	SNP	C	C	T			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:55534066C>T	uc003xsd.1	+	2	688	c.540C>T	c.(538-540)TTC>TTT	p.F180F	RP1_uc011ldy.1_Silent_p.F180F	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	180	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCCAGAGCTTCGAGGCATTTC	0.637		NA											99	157					0	0	0	0
PDE7A	5150	broad.mit.edu	37	8	66691967	66691967	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:66691967G>A	uc003xvq.2	-	3	283	c.271C>T	c.(271-273)CGT>TGT	p.R91C	PDE7A_uc003xvr.2_Missense_Mutation_p.R91C|PDE7A_uc003xvp.2_Missense_Mutation_p.R65C	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	91						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	TGGAAAATACGAAAATCAATA	0.353		NA											8	191					0	0	0	0
ASAP1	50807	broad.mit.edu	37	8	131130883	131130883	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:131130883T>G	uc003yta.1	-	18	1674	c.1646A>C	c.(1645-1647)GAT>GCT	p.D549A	ASAP1_uc003ysz.1_Missense_Mutation_p.D360A|ASAP1_uc011liw.1_Missense_Mutation_p.D542A	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	549	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AAACCTATGATCTACATACTT	0.333		NA											35	32					0	0	0	0
RECK	8434	broad.mit.edu	37	9	36110017	36110017	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:36110017G>A	uc003zyv.2	+	15	1915	c.1829G>A	c.(1828-1830)TGC>TAC	p.C610Y	RECK_uc003zyw.2_Missense_Mutation_p.C482Y|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	610						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			AATTTGGTGTGCTCTACCCGC	0.463		NA											118	193					0	0	0	0
C9orf5	23731	broad.mit.edu	37	9	111795700	111795700	+	Silent	SNP	A	A	G			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:111795700A>G	uc004bdt.3	-	17	2513	c.2481T>C	c.(2479-2481)CCT>CCC	p.P827P	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Silent_p.P819P	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	827	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		AGAGAAGAATAGGACCGATGA	0.527		NA											3	186					0	0	0	0
SPTAN1	6709	broad.mit.edu	37	9	131388129	131388129	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:131388129G>A	uc004bvl.3	+	47	6249	c.6136G>A	c.(6136-6138)GCC>ACC	p.A2046T	SPTAN1_uc004bvm.3_Missense_Mutation_p.A2051T|SPTAN1_uc004bvn.3_Missense_Mutation_p.A2026T|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2046	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCTTCTCGCCGCCAAACACGT	0.582		NA											6	314					0	0	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240782	39240796	+	In_Frame_Del	DEL	CTGCTGCCGCCCCAG	CTGCTGCCGCCCCAG	-	rs11650261	by1000genomes	TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr17:39240782_39240796delCTGCTGCCGCCCCAG	uc010wfn.1	+	1	324_338	c.324_338delCTGCTGCCGCCCCAG	c.(322-339)ACCTGCTGCCGCCCCAGC>ACC	p.CCRPS109del		NM_033061	NP_149050			keratin associated protein 4-7												0						gccagcccacctgctgccgccccagctgctgccgc	0.228		NA											8	61	---	---	---	---	NA	NA	NA	NA
PHC3	80012	broad.mit.edu	37	3	169896635	169896637	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:169896635_169896637delTGG	uc010hws.1	-	2	132_134	c.68_70delCCA	c.(67-72)ACCATC>ATC	p.T23del	PHC3_uc003fgl.2_In_Frame_Del_p.T35del|PHC3_uc011bpq.1_In_Frame_Del_p.T35del|PHC3_uc011bpr.1_In_Frame_Del_p.T35del|PHC3_uc003fgm.2_In_Frame_Del_p.T35del|PHC3_uc003fgo.1_In_Frame_Del_p.T23del|PHC3_uc003fgp.3_In_Frame_Del_p.T35del|PHC3_uc003fgq.3_In_Frame_Del_p.T35del|PHC3_uc003fgr.1_RNA	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	23	Poly-Thr.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAAgtggtgatggtggtggtggt	0.424		NA											8	852	---	---	---	---	NA	NA	NA	NA
MUC20	200958	broad.mit.edu	37	3	195452996	195452997	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:195452996_195452997delAG	uc010hzo.2	+	3	1135_1136	c.1009_1010delAG	c.(1009-1011)AGAfs	p.R337fs	MUC20_uc010hzp.2_Frame_Shift_Del_p.R302fs|MUC20_uc011bte.1_RNA	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	508	Involved in oligomerization.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CGCCACAGAAAGAGAAGTGACA	0.604		NA											14	126	---	---	---	---	NA	NA	NA	NA
NOV	4856	broad.mit.edu	37	8	120428777	120428778	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:120428777_120428778delAG	uc003yoq.2	+	1	226_227	c.5_6delAG	c.(4-6)CAGfs	p.Q2fs		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	2					regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGAGCATGCAGAGTGTGCAGA	0.55		NA									OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	41	---	---	---	---	NA	NA	NA	NA
