Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRDM2	7799	broad.mit.edu	37	1	14108768	14108768	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:14108768C>T	uc001avi.2	+	8	5334	c.4478C>T	c.(4477-4479)TCA>TTA	p.S1493L	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1493L|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S1292L|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1493						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTTTCTCATTCATCTAAGAAA	0.448		NA											56	161					0	0	0	0
CROCC	9696	broad.mit.edu	37	1	17275397	17275397	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:17275397C>T	uc001azt.2	+	19	2881	c.2812C>T	c.(2812-2814)CTG>TTG	p.L938L	CROCC_uc009voz.1_Intron|CROCC_uc001azu.2_Silent_p.L241L	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	938	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCAGGCCCTGCTGCTGGCCAA	0.677		NA											5	67					0	0	0	0
DOCK7	85440	broad.mit.edu	37	1	63027299	63027299	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:63027299T>C	uc001daq.2	-	19	2222	c.2188A>G	c.(2188-2190)ATC>GTC	p.I730V	DOCK7_uc001dan.2_Missense_Mutation_p.I622V|DOCK7_uc001dao.2_Missense_Mutation_p.I622V|DOCK7_uc001dap.2_Missense_Mutation_p.I730V	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	730	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TGTGTATGGATAGACGAAACA	0.294		NA											39	66					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103474059	103474059	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:103474059G>T	uc001dul.2	-	15	1961	c.1643C>A	c.(1642-1644)TCA>TAA	p.S548*	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Nonsense_Mutation_p.S560*|COL11A1_uc001dun.2_Nonsense_Mutation_p.S509*|COL11A1_uc009weh.2_Nonsense_Mutation_p.S432*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	548	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCCAGATGAACCAGGCCC	0.299		NA											14	36					1.36e-06	1.67e-06	1	0
ATP1A1	476	broad.mit.edu	37	1	116927412	116927412	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:116927412A>G	uc001ege.2	+	3	470	c.131A>G	c.(130-132)CAT>CGT	p.H44R	ATP1A1_uc010owv.1_Missense_Mutation_p.H13R|ATP1A1_uc001egd.2_Missense_Mutation_p.H44R|ATP1A1_uc010oww.1_Missense_Mutation_p.H44R|ATP1A1_uc010owx.1_Missense_Mutation_p.H13R	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	44	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TAGGATGATCATAAACTTAGC	0.313		NA											22	39					0	0	0	0
SMG5	23381	broad.mit.edu	37	1	156243195	156243195	+	Silent	SNP	G	G	A	rs151161240	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:156243195G>A	uc001foc.3	-	6	740	c.591C>T	c.(589-591)GCC>GCT	p.A197A		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	197					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					AAAATCTCTCGGCTAGCAGCT	0.468		NA											19	32					0	0	0	0
GORAB	92344	broad.mit.edu	37	1	170508524	170508524	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170508524C>A	uc001gha.2	+	2	337	c.310C>A	c.(310-312)CCT>ACT	p.P104T	GORAB_uc009wvw.2_3'UTR|GORAB_uc001ggz.3_Missense_Mutation_p.P104T|GORAB_uc009wvx.2_5'UTR|GORAB_uc001ghb.2_5'UTR|GORAB_uc001ghc.2_5'UTR	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	104						Golgi apparatus|nucleus					0						TCAAAAACCACCTTTTTCTTC	0.473		NA											16	43					0.000308642	0.000362379	1	0
C1orf129	80133	broad.mit.edu	37	1	170965783	170965783	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170965783T>C	uc001ghg.2	+	14	1603	c.1473T>C	c.(1471-1473)GCT>GCC	p.A491A	C1orf129_uc009wvy.2_Silent_p.A298A|C1orf129_uc010plz.1_Silent_p.A491A	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	491							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTTTATTGCTAAGTAAGAAC	0.428		NA											4	136					0	0	0	0
STX6	10228	broad.mit.edu	37	1	180959168	180959168	+	Silent	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:180959168G>C	uc010pnq.1	-	5	678	c.441C>G	c.(439-441)CTC>CTG	p.L147L	STX6_uc001goo.2_Silent_p.L147L|STX6_uc010pnr.1_Silent_p.L46L	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	147	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1						TGGCTCTCTGGAGCTCTCGGT	0.557		NA											48	66					0	0	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306715	205306715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:205306715G>A	uc001hcf.1	-	6	1433	c.865C>T	c.(865-867)CAA>TAA	p.Q289*	KLHDC8A_uc010prg.1_Nonsense_Mutation_p.Q176*|KLHDC8A_uc001hcg.1_Nonsense_Mutation_p.Q289*	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	289	Kelch 7.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGTGGGTTGATTCCCTGAA	0.587		NA											45	51					0	0	0	0
INTS7	25896	broad.mit.edu	37	1	212120048	212120048	+	Splice_Site	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:212120048C>T	uc001hiw.1	-	18	2422	c.2317_splice	c.e18-1	p.H773_splice	INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Splice_Site_p.H649_splice|INTS7_uc001hiy.1_Splice_Site_p.H759_splice|INTS7_uc010pta.1_Splice_Site_p.H724_splice	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7						snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ATGCTGTGTGCTGGGGGAAAA	0.348		NA											3	58					0	0	0	0
SPHAR	10638	broad.mit.edu	37	1	229440922	229440922	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:229440922A>G	uc001htk.3	+	1	794	c.41A>G	c.(40-42)TAT>TGT	p.Y14C		NM_006542	NP_006533	Q15513	SPHAR_HUMAN	S-phase response (cyclin-related)	14					DNA replication						0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)				TGTTTTAGATATTTTGAGTTT	0.299		NA											26	32					0	0	0	0
OR2G3	81469	broad.mit.edu	37	1	247769130	247769130	+	Silent	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:247769130C>G	uc010pyz.1	+	1	243	c.243C>G	c.(241-243)ACC>ACG	p.T81T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCCTCAGACCTTAGTTAACT	0.458		NA											120	194					0	0	0	0
OR2G6	391211	broad.mit.edu	37	1	248684984	248684984	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:248684984C>G	uc001ien.1	+	1	37	c.37C>G	c.(37-39)CTT>GTT	p.L13V		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAGGGATTTCTTCTCCTGGG	0.423		NA											44	75					0	0	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249107242	249107242	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:249107242G>A	uc001iew.1	-	6	1209	c.657C>T	c.(655-657)ATC>ATT	p.I219I	SH3BP5L_uc010pzp.1_Silent_p.I112I|SH3BP5L_uc010pzq.1_Silent_p.I187I|SH3BP5L_uc001iev.1_Silent_p.I100I	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	219	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCTCTTGCCGATGGCCCTCC	0.652		NA											25	43					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55568819	55568819	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:55568819C>G	uc010qhs.1	-	37	5401	c.5006G>C	c.(5005-5007)AGA>ACA	p.R1669T	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.R1662T|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CATGGGCCTTCTTCTTGCAAG	0.348		NA								HNSCC(58;0.16)			11	25					0	0	0	0
LCOR	84458	broad.mit.edu	37	10	98714920	98714920	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:98714920G>C	uc001kms.1	+	8	1064	c.543G>C	c.(541-543)CAG>CAC	p.Q181H	LCOR_uc001kmr.2_Missense_Mutation_p.Q181H|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.Q181H|LCOR_uc001kmu.1_Missense_Mutation_p.Q181H	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	181						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTGGATTACAGAATCATGGAC	0.478		NA											24	34					0	0	0	0
OR51G1	79324	broad.mit.edu	37	11	4945555	4945555	+	Silent	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:4945555A>C	uc010qyr.1	-	1	15	c.15T>G	c.(13-15)CTT>CTG	p.L5L		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCTGCTATTAAGAAGAATTG	0.438		NA											31	12					0	0	0	0
HPX	3263	broad.mit.edu	37	11	6453230	6453230	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:6453230G>C	uc001mdg.2	-	8	914	c.853C>G	c.(853-855)CTG>GTG	p.L285V	HPX_uc001mdf.2_Missense_Mutation_p.L31V|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	285	Hemopexin-like 4.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CTGGTGTCCAGACGCCAGTAG	0.567		NA											66	31					0	0	0	0
GTF2H1	2965	broad.mit.edu	37	11	18369136	18369136	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:18369136G>T	uc001moi.2	+	9	1533	c.839G>T	c.(838-840)GGC>GTC	p.G280V	GTF2H1_uc001moh.2_Missense_Mutation_p.G280V|GTF2H1_uc009yhm.2_Missense_Mutation_p.G164V|GTF2H1_uc001moj.2_5'UTR	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	280					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						ttCTCACAGGGCTATGGCATT	0.343		NA						NER					10	23					7.48e-07	9.2e-07	1	0
LRP4	4038	broad.mit.edu	37	11	46900527	46900527	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:46900527G>C	uc001ndn.3	-	22	3213	c.3067C>G	c.(3067-3069)CCA>GCA	p.P1023A		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1023	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AATCCGCTTGGATTTGGGGAC	0.537		NA											117	125					0	0	0	0
OR5W2	390148	broad.mit.edu	37	11	55681486	55681486	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:55681486A>T	uc010rir.1	-	1	573	c.573T>A	c.(571-573)GAT>GAA	p.D191E		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGACCTGTGTATCTGAGCGAG	0.383		NA											10	68					0	0	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310543	57310543	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:57310543A>T	uc009ymh.1	+	2	482	c.482A>T	c.(481-483)GAG>GTG	p.E161V		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	143										ovary(1)	1						GAGGAGAAAGAGGCCAAACCT	0.532		NA											4	18					0	0	0	0
C11orf84	144097	broad.mit.edu	37	11	63594564	63594564	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:63594564T>G	uc001nxt.2	+	6	1335	c.1099T>G	c.(1099-1101)TCC>GCC	p.S367A	C11orf84_uc001nxu.1_RNA	NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	367											0						TCTGTCAGAATCCAGCACCAC	0.617		NA											11	44					0	0	0	0
RELA	5970	broad.mit.edu	37	11	65425831	65425831	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65425831G>A	uc001ofg.2	-	8	944	c.804C>T	c.(802-804)GTC>GTT	p.V268V	RELA_uc001ofh.2_Silent_p.V265V|RELA_uc010ron.1_Silent_p.V279V|RELA_uc009yqr.2_Silent_p.V215V|RELA_uc001ofe.2_Silent_p.V268V|RELA_uc001off.2_Silent_p.V268V|RELA_uc009yqs.1_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	268	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						GCTGCATGGAGACACGCACAG	0.627		NA											25	43					0	0	0	0
CATSPER1	117144	broad.mit.edu	37	11	65792826	65792826	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65792826G>T	uc001ogt.2	-	1	1163	c.1025C>A	c.(1024-1026)GCT>GAT	p.A342D		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	342	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						ACGAGAAGCAGCAGGGCCGGG	0.587		NA											30	44					1.31e-18	1.7e-18	1	0
SHANK2	22941	broad.mit.edu	37	11	70333469	70333469	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:70333469A>C	uc001oqc.2	-	21	3007	c.2929T>G	c.(2929-2931)TTC>GTC	p.F977V	SHANK2_uc010rqn.1_Missense_Mutation_p.F389V|SHANK2_uc001opz.2_Missense_Mutation_p.F382V|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	598					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTGCGGAAGTTGGCTTGC	0.587		NA											46	724					0	0	0	0
ARAP1	116985	broad.mit.edu	37	11	72415374	72415374	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:72415374G>C	uc001osu.2	-	14	2004	c.1815C>G	c.(1813-1815)TTC>TTG	p.F605L	ARAP1_uc001osv.2_Missense_Mutation_p.F605L|ARAP1_uc001osr.2_Missense_Mutation_p.F365L|ARAP1_uc001oss.2_Missense_Mutation_p.F360L|ARAP1_uc009yth.2_Intron|ARAP1_uc010rre.1_Missense_Mutation_p.F360L|ARAP1_uc001osw.1_5'Flank	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	605	Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCAGCTGTAAGAAGAGCTGTG	0.667		NA											11	56					0	0	0	0
PCF11	51585	broad.mit.edu	37	11	82878338	82878338	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:82878338A>G	uc001ozx.3	+	6	2334	c.1989A>G	c.(1987-1989)GAA>GAG	p.E663E	PCF11_uc010rsu.1_Silent_p.E663E	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	663					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GCAAAAGAGAATTACTTCAAA	0.313		NA											12	35					0	0	0	0
PICALM	8301	broad.mit.edu	37	11	85718613	85718613	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:85718613T>C	uc001pbm.2	-	8	1065	c.779A>G	c.(778-780)GAC>GGC	p.D260G	PICALM_uc001pbl.2_Missense_Mutation_p.D260G|PICALM_uc001pbn.2_Missense_Mutation_p.D260G|PICALM_uc010rtl.1_Missense_Mutation_p.D209G|PICALM_uc001pbo.1_5'UTR	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	260					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				ATCACCTCTGTCAATTCCAAC	0.289		NA	T	MLLT10|MLL	TALL|AML|								3	96					0	0	0	0
TAF1D	79101	broad.mit.edu	37	11	93472441	93472441	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:93472441G>C	uc001ped.2	-	2	232	c.30C>G	c.(28-30)GAC>GAG	p.D10E	TAF1D_uc001pdz.2_RNA|TAF1D_uc001pea.1_RNA|C11orf54_uc001pee.1_5'Flank|C11orf54_uc001pef.2_5'Flank|C11orf54_uc009ywi.2_5'Flank|C11orf54_uc001peg.2_5'Flank|C11orf54_uc001peh.2_5'Flank|C11orf54_uc001pei.2_5'Flank	NM_024116	NP_077021	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						ATGTCACATGGTCAAGAGAAT	0.308		NA											14	69					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	99715973	99715973	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:99715973G>C	uc001pga.2	+	6	895	c.556G>C	c.(556-558)GAA>CAA	p.E186Q	CNTN5_uc009ywv.1_Missense_Mutation_p.E186Q|CNTN5_uc001pfz.2_Missense_Mutation_p.E186Q|CNTN5_uc001pgb.2_Missense_Mutation_p.E112Q	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	186	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCTTAGTAGAGAAGCTACACT	0.338		NA											38	362					0	0	0	0
PDGFD	80310	broad.mit.edu	37	11	103870957	103870957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:103870957G>A	uc001phq.2	-	2	523	c.151C>T	c.(151-153)CGA>TGA	p.R51*	PDGFD_uc001php.2_Nonsense_Mutation_p.R45*	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	51					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TCATCTCTTCGGTACAAGTCT	0.458		NA											25	353					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117387378	117387378	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:117387378G>A	uc001prh.1	-	8	1769	c.1767C>T	c.(1765-1767)ATC>ATT	p.I589I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	529	Extracellular (Potential).|Ig-like C2-type 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGATAGCCGATGACCCTGC	0.592		NA											7	23					0	0	0	0
TECTA	7007	broad.mit.edu	37	11	121000847	121000847	+	Silent	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:121000847T>G	uc010rzo.1	+	9	2868	c.2868T>G	c.(2866-2868)TCT>TCG	p.S956S		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	956					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTGTGACTCTGTGGCCCGGT	0.602		NA											21	43					0	0	0	0
SOX5	6660	broad.mit.edu	37	12	23716248	23716248	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:23716248C>G	uc001rfw.2	-	11	1534	c.1432G>C	c.(1432-1434)GAT>CAT	p.D478H	SOX5_uc001rfx.2_Missense_Mutation_p.D465H|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.D92H|SOX5_uc010siv.1_Missense_Mutation_p.D465H|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.D430H	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	478	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ACCTTCCCATCAAGCACCTGT	0.418		NA											38	49					0	0	0	0
TMEM117	84216	broad.mit.edu	37	12	44537363	44537363	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:44537363A>G	uc001rod.2	+	4	512	c.446A>G	c.(445-447)AAT>AGT	p.N149S	TMEM117_uc001roe.2_Intron|TMEM117_uc009zkc.2_Missense_Mutation_p.N149S	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	149						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GGCATCCGAAATGAAAGTTTC	0.408		NA											20	36					0	0	0	0
CCT2	10576	broad.mit.edu	37	12	69986801	69986801	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:69986801G>C	uc001svb.1	+	9	890	c.796G>C	c.(796-798)GAA>CAA	p.E266Q	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.E266Q|CCT2_uc010stl.1_Missense_Mutation_p.E219Q	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	266					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAAGGTTGCAGAAATAGAACA	0.328		NA											13	35					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72667201	72667201	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:72667201C>A	uc001sxa.2	+	1	673	c.643C>A	c.(643-645)CAG>AAG	p.Q215K	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	215	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCCGCAAACCCAGGTCTTAGT	0.572		NA											28	34					1.75e-13	2.25e-13	1	0
SLC6A15	55117	broad.mit.edu	37	12	85266514	85266514	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:85266514G>A	uc001szv.2	-	8	1662	c.1169C>T	c.(1168-1170)CCC>CTC	p.P390L	SLC6A15_uc010sul.1_Missense_Mutation_p.P283L|SLC6A15_uc001szw.1_Missense_Mutation_p.P98L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	390	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GATATGATGGGGAATAATATC	0.323		NA											3	37					0	0	0	0
KIAA1033	23325	broad.mit.edu	37	12	105556620	105556620	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:105556620A>G	uc001tld.2	+	30	3241	c.3154A>G	c.(3154-3156)ATG>GTG	p.M1052V	KIAA1033_uc010swr.1_Missense_Mutation_p.M1053V|KIAA1033_uc010sws.1_Missense_Mutation_p.M864V	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1052					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TGGCTTTGCCATGGGTAAGCT	0.308		NA											4	16					0	0	0	0
SH2B3	10019	broad.mit.edu	37	12	111886081	111886081	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:111886081T>C	uc001tse.2	+	8	2060	c.1703T>C	c.(1702-1704)ATA>ACA	p.I568T	SH2B3_uc010syf.1_Missense_Mutation_p.I568T|SH2B3_uc001tsf.2_Missense_Mutation_p.I569T|SH2B3_uc010syg.1_Missense_Mutation_p.I366T	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	568					blood coagulation	cytosol	signal transducer activity			ovary(1)	1						CTGCGGGCCATAGACAATCAG	0.562		NA											6	10					0	0	0	0
TAOK3	51347	broad.mit.edu	37	12	118650751	118650751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:118650751G>A	uc001twx.2	-	11	1082	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	TAOK3_uc001tww.2_Nonsense_Mutation_p.Q93*|TAOK3_uc001twy.3_Nonsense_Mutation_p.Q263*	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	263	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCTTTCCTGAGGTATTTTC	0.348		NA											17	12					0	0	0	0
NCOR2	9612	broad.mit.edu	37	12	124821412	124821412	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:124821412G>C	uc010tay.1	-	40	6188	c.6032C>G	c.(6031-6033)CCT>CGT	p.P2011R	NCOR2_uc010taz.1_Missense_Mutation_p.P1995R|NCOR2_uc010tax.1_Missense_Mutation_p.P122R	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2012					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCGTGGTGAGGTGCGAGGTT	0.687		NA											18	16					0	0	0	0
NHLRC3	387921	broad.mit.edu	37	13	39621219	39621219	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:39621219G>A	uc001uxc.2	+	6	1043	c.721G>A	c.(721-723)GAT>AAT	p.D241N	NHLRC3_uc001uxd.2_Missense_Mutation_p.D174N|NHLRC3_uc001uxe.2_Missense_Mutation_p.D44N	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	241	NHL 3.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		CCAAGTATTTGATAAAGACAC	0.363		NA											53	25					0	0	0	0
KIAA0564	23078	broad.mit.edu	37	13	42293870	42293870	+	Silent	SNP	C	C	T	rs140209374		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:42293870C>T	uc001uyj.2	-	26	3043	c.2973G>A	c.(2971-2973)CCG>CCA	p.P991P	KIAA0564_uc001uyk.2_Silent_p.P991P	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	991						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GACCTTCAGTCGGAAATTTCT	0.303		NA											28	14					0	0	0	0
ACIN1	22985	broad.mit.edu	37	14	23547373	23547373	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:23547373T>C	uc001wit.3	-	8	2612	c.2284A>G	c.(2284-2286)ATT>GTT	p.I762V	ACIN1_uc001wis.3_Missense_Mutation_p.I444V|ACIN1_uc010akg.2_Missense_Mutation_p.I762V	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	762					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTGTGATGAATTCTTTCTGAT	0.493		NA											68	106					0	0	0	0
NOVA1	4857	broad.mit.edu	37	14	26949229	26949229	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:26949229C>A	uc001wpy.2	-	3	719	c.401G>T	c.(400-402)AGC>ATC	p.S134I	NOVA1_uc001wpz.2_Missense_Mutation_p.S134I|NOVA1_uc001wqa.2_Missense_Mutation_p.S12I|NOVA1_uc001wqb.2_Missense_Mutation_p.S134I	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	137					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TTGTAGAATGCTGACTGGTTC	0.418		NA											48	86					6.91e-35	9.14e-35	1	0
SYNE2	23224	broad.mit.edu	37	14	64494410	64494410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:64494410C>T	uc001xgm.2	+	43	6843	c.6613C>T	c.(6613-6615)CAG>TAG	p.Q2205*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q2205*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2205	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTTAAAATCTCAGGGAAACTA	0.403		NA											25	38					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415528	105415528	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:105415528T>C	uc010axc.1	-	7	6380	c.6260A>G	c.(6259-6261)AAG>AGG	p.K2087R	AHNAK2_uc001ypx.2_Missense_Mutation_p.K1987R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2087						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGGCCCTTGAGGTCCAC	0.612		NA											127	200					0	0	0	0
TRPM1	4308	broad.mit.edu	37	15	31294736	31294736	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:31294736T>C	uc001zfm.2	-	27	4229	c.4101A>G	c.(4099-4101)AGA>AGG	p.R1367R	TRPM1_uc010azy.2_Silent_p.R1274R|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1367	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGTCTGTCTGTCTTTCATCAT	0.378		NA											64	66					0	0	0	0
DUOX1	53905	broad.mit.edu	37	15	45434285	45434285	+	Silent	SNP	C	C	T	rs140249290	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:45434285C>T	uc001zus.1	+	16	2143	c.1797C>T	c.(1795-1797)ATC>ATT	p.I599I	DUOX1_uc001zut.1_Silent_p.I599I|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	599	Helical; (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GGGTCACCATCGGGACCCTCT	0.557		NA											7	95					0	0	0	0
RASL12	51285	broad.mit.edu	37	15	65347288	65347288	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:65347288G>T	uc002aoi.1	-	5	965	c.750C>A	c.(748-750)AGC>AGA	p.S250R	RASL12_uc002aoj.1_Missense_Mutation_p.S231R|RASL12_uc010uir.1_Missense_Mutation_p.S239R	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	250					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						CCTTGCGCTTGCTCTGGGCCC	0.627		NA									OREG0023189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	15					2.23e-06	2.71e-06	1	0
SH2D7	646892	broad.mit.edu	37	15	78390796	78390796	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:78390796C>T	uc010blb.1	+	4	503	c.503C>T	c.(502-504)CCA>CTA	p.P168L		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	168											0						CCAGAAAACCCACCTGCCACG	0.607		NA											15	24					0	0	0	0
AEN	64782	broad.mit.edu	37	15	89173493	89173493	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:89173493G>T	uc002bmt.2	+	4	1097	c.946G>T	c.(946-948)GGA>TGA	p.G316*	AEN_uc010bnm.1_Intron	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	316					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						CAGCAGAGGAGGAGCCAGGGA	0.647		NA											8	9					0.00448238	0.00517047	1	0
ADCY9	115	broad.mit.edu	37	16	4165167	4165167	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4165167G>A	uc002cvx.2	-	2	816	c.277C>T	c.(277-279)CCC>TCC	p.P93S		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	93	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TCGAACTTGGGGTCCCACCAG	0.706		NA											12	42					0	0	0	0
TFAP4	7023	broad.mit.edu	37	16	4308235	4308235	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4308235C>T	uc010uxg.1	-	7	1092	c.838G>A	c.(838-840)GAG>AAG	p.E280K		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	280					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGGGTGCCCTCGATGTGCTGG	0.657		NA											18	30					0	0	0	0
GPRC5B	51704	broad.mit.edu	37	16	19871853	19871853	+	Missense_Mutation	SNP	G	G	A	rs147744945		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:19871853G>A	uc002dgt.2	-	4	1289	c.1181C>T	c.(1180-1182)CCG>CTG	p.P394L	GPRC5B_uc010vav.1_Missense_Mutation_p.P420L	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	394	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						GTGACTTGGCGGAGCAGTTGG	0.448		NA											14	23					0	0	0	0
TNRC6A	27327	broad.mit.edu	37	16	24800634	24800634	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:24800634A>T	uc002dmm.2	+	6	785	c.671A>T	c.(670-672)AAC>ATC	p.N224I	TNRC6A_uc010bxs.2_5'UTR|TNRC6A_uc010vcc.1_5'UTR|TNRC6A_uc002dmn.2_5'UTR|TNRC6A_uc002dmo.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	224	Ser-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TCTAGCACAAACTGTAAGAAT	0.448		NA											47	62					0	0	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29906732	29906732	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29906732C>T	uc002duq.3	-	5	941	c.701G>A	c.(700-702)GGT>GAT	p.G234D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.G164D|SEZ6L2_uc002dur.3_Missense_Mutation_p.G164D|SEZ6L2_uc002dus.3_Intron|SEZ6L2_uc010vec.1_Missense_Mutation_p.G234D|SEZ6L2_uc010ved.1_Missense_Mutation_p.G190D	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	234	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGATCCCCCACCAGCCAGCAC	0.622		NA											34	50					0	0	0	0
TMEM219	124446	broad.mit.edu	37	16	29979372	29979372	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29979372A>T	uc002duw.2	+	4	549	c.382A>T	c.(382-384)ATC>TTC	p.I128F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TMEM219_uc002duy.2_Missense_Mutation_p.I128F|TMEM219_uc010bzk.1_Missense_Mutation_p.I128F|TMEM219_uc002duz.2_Missense_Mutation_p.I128F|TMEM219_uc010bzl.1_RNA	NM_194280	NP_919256	Q86XT9	TM219_HUMAN	transmembrane protein 219	128						integral to membrane					0						ACTGGTCCTTATCACAGCCAG	0.507		NA											61	101					0	0	0	0
ABCC12	94160	broad.mit.edu	37	16	48138167	48138167	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:48138167T>G	uc002efc.1	-	20	3132	c.2786A>C	c.(2785-2787)AAC>ACC	p.N929T	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	929	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTGCAGAAAGTTCTCTGCGTG	0.493		NA											15	310					0	0	0	0
DHX38	9785	broad.mit.edu	37	16	72143370	72143370	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:72143370C>T	uc002fcb.2	+	25	3793	c.3438C>T	c.(3436-3438)CCC>CCT	p.P1146P	DHX38_uc010vmp.1_Silent_p.P458P	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1146					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				AGCTGGGCCCCATGTTCTATA	0.637		NA											8	23					0	0	0	0
CLEC18B	497190	broad.mit.edu	37	16	74455117	74455117	+	Silent	SNP	G	G	A	rs141907838	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:74455117G>A	uc002fct.2	-	1	252	c.52C>T	c.(52-54)CTG>TTG	p.L18L	CLEC18B_uc002fcu.2_Silent_p.L18L|CLEC18B_uc010vmu.1_Silent_p.L18L|CLEC18B_uc010vmw.1_Silent_p.L18L	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	18						extracellular region	sugar binding				0						AGGAGGGCCAGGAGCACAGCC	0.682		NA											24	99					0	0	0	0
CTU2	348180	broad.mit.edu	37	16	88780121	88780121	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:88780121G>A	uc002flm.2	+	9	988	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CTU2_uc002fln.2_Missense_Mutation_p.E314K|CTU2_uc010chz.2_Missense_Mutation_p.E385K|CTU2_uc010cia.2_Missense_Mutation_p.E227K	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	314					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1						CACCCTGAAGGAGGTCGCTTT	0.637		NA											44	106					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578268	7578268	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:7578268A>G	uc002gim.2	-	6	775	c.581T>C	c.(580-582)CTT>CCT	p.L194P	TP53_uc002gig.1_Missense_Mutation_p.L194P|TP53_uc002gih.2_Missense_Mutation_p.L194P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L62P|TP53_uc010cng.1_Missense_Mutation_p.L62P|TP53_uc002gii.1_Missense_Mutation_p.L62P|TP53_uc010cnh.1_Missense_Mutation_p.L194P|TP53_uc010cni.1_Missense_Mutation_p.L194P|TP53_uc002gij.2_Missense_Mutation_p.L194P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.L101P|TP53_uc002gio.2_Missense_Mutation_p.L62P|TP53_uc010vug.1_Missense_Mutation_p.L155P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.A189fs*53(1)|p.L194V(1)|p.L194fs*14(1)|p.P191fs*6(1)|p.I195fs*52(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194I(1)|p.L194fs*52(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	12					0	0	0	0
VTN	7448	broad.mit.edu	37	17	26696658	26696658	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26696658C>G	uc002hbc.2	-	3	548	c.399G>C	c.(397-399)GAG>GAC	p.E133D	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	133					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	AGTCTATCCCCTCAGGCTTAG	0.622		NA											17	21					0	0	0	0
KIAA0100	9703	broad.mit.edu	37	17	26962035	26962035	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26962035G>T	uc002hbu.2	-	16	2669	c.2570C>A	c.(2569-2571)GCT>GAT	p.A857D		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	857						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGGCCCAAGCACGAGTCCC	0.483		NA											85	106					3.62e-53	4.83e-53	1	0
TIAF1	9220	broad.mit.edu	37	17	27400997	27400997	+	Missense_Mutation	SNP	T	T	C	rs115510379	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:27400997T>C	uc002hdv.1	-	1	1631	c.221A>G	c.(220-222)AAT>AGT	p.N74S	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	74					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAATAGGTCATTGCACATAAC	0.552		NA											25	74					0	0	0	0
RFFL	117584	broad.mit.edu	37	17	33348470	33348470	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:33348470G>T	uc002hin.1	-	3	684	c.511C>A	c.(511-513)CCA>ACA	p.P171T	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.P171T|RFFL_uc010cti.1_Missense_Mutation_p.P177T|RFFL_uc002hip.1_Missense_Mutation_p.P171T|RFFL_uc002hio.1_Missense_Mutation_p.P171T	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	171					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GAGGTAGGTGGAACCATGCTG	0.587		NA											13	19					2.27e-07	2.82e-07	1	0
HEXIM1	10614	broad.mit.edu	37	17	43226879	43226879	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:43226879G>C	uc002iig.2	+	1	2196	c.322G>C	c.(322-324)GAA>CAA	p.E108Q		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	108					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GCCGCCGGCAGAAGTGGAACC	0.677		NA									OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	5					0	0	0	0
PPM1D	8493	broad.mit.edu	37	17	58678140	58678140	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:58678140G>T	uc002iyt.1	+	1	587	c.365G>T	c.(364-366)GGT>GTT	p.G122V	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	122	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			CACTTGTGGGGTTTCATCAAG	0.637		NA											7	35					1.26e-09	1.6e-09	1	0
BPTF	2186	broad.mit.edu	37	17	65905793	65905793	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:65905793G>A	uc002jgf.2	+	10	2969	c.2908G>A	c.(2908-2910)GAT>AAT	p.D970N	BPTF_uc002jge.2_Missense_Mutation_p.D1096N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1096					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTCTGAAAAAGATGAGGTAAA	0.343		NA											11	43					0	0	0	0
CCDC57	284001	broad.mit.edu	37	17	80156247	80156247	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:80156247T>C	uc002kdz.1	-	4	814	c.459A>G	c.(457-459)AAA>AAG	p.K153K	CCDC57_uc002kdx.1_Silent_p.K153K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	153	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CCAGTGTCCATTTTAGATTTT	0.478		NA											3	34					0	0	0	0
FHOD3	80206	broad.mit.edu	37	18	34298136	34298136	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:34298136G>C	uc002kzt.1	+	15	2396	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	FHOD3_uc002kzs.1_Missense_Mutation_p.E784Q|FHOD3_uc010dmz.1_Missense_Mutation_p.E499Q|FHOD3_uc010dna.1_Missense_Mutation_p.E87Q	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	767					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCCTGATGCTGAGCCCAATGA	0.542		NA											41	249					0	0	0	0
PIK3C3	5289	broad.mit.edu	37	18	39629561	39629561	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:39629561C>G	uc002lap.2	+	21	2313	c.2255C>G	c.(2254-2256)ACA>AGA	p.T752R	PIK3C3_uc010xcl.1_Missense_Mutation_p.T689R|PIK3C3_uc002laq.2_Missense_Mutation_p.T237R|PIK3C3_uc002lar.1_Missense_Mutation_p.T136R	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	752	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CTTTTGCTAACAAAAACAGGT	0.353		NA								TSP Lung(28;0.18)			34	19					0	0	0	0
MED16	10025	broad.mit.edu	37	19	885883	885883	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:885883C>T	uc002lqd.1	-	5	917	c.766G>A	c.(766-768)GAC>AAC	p.D256N	MED16_uc010drw.1_Missense_Mutation_p.D81N|MED16_uc002lqe.2_Missense_Mutation_p.D245N|MED16_uc002lqf.2_Missense_Mutation_p.D245N|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.D245N|MED16_uc010xfx.1_Intron|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	256					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCCGTGTCGATACGGCAC	0.647		NA											4	66					0	0	0	0
FUT5	2527	broad.mit.edu	37	19	5867283	5867283	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:5867283A>G	uc002mdo.3	-	2	542	c.454T>C	c.(454-456)TCC>CCC	p.S152P	FUT5_uc010duo.2_Missense_Mutation_p.S152P	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	152	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTGCTGGGGGACTCCATGCTG	0.627		NA											7	30					0	0	0	0
RAVER1	125950	broad.mit.edu	37	19	10434234	10434234	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:10434234G>A	uc002moa.2	-	4	896	c.816C>T	c.(814-816)TGC>TGT	p.C272C		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CATCCTGGCCGCACGCCAGCT	0.667		NA											7	26					0	0	0	0
JAK3	3718	broad.mit.edu	37	19	17948809	17948809	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:17948809C>G	uc002nhn.3	-	12	1733	c.1633G>C	c.(1633-1635)GAT>CAT	p.D545H	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.D545H	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	545	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GCCTCCCCATCCACCACCTCA	0.567		2	Mis		acute megakaryocytic leukemia|								67	95					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22942464	22942464	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:22942464G>C	uc010xrh.1	-	4	310	c.310C>G	c.(310-312)CAA>GAA	p.Q104E		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CAAAAGTCTTGTGTAAAATGA	0.279		NA											16	17					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23544197	23544197	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544197T>C	uc002nre.2	-	4	1697	c.1584A>G	c.(1582-1584)AGA>AGG	p.R528R	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Silent_p.R496R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	528	C2H2-type 14; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTAAGGATTGTCTAAAAGCTT	0.343		NA											9	20					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23544264	23544264	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544264G>T	uc002nre.2	-	4	1630	c.1517C>A	c.(1516-1518)ACT>AAT	p.T506N	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.T474N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	506	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTTATGTTTAGTAAGGGTTGA	0.363		NA											9	31					5.49e-09	6.9e-09	1	0
ZNF91	7644	broad.mit.edu	37	19	23544273	23544273	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544273G>A	uc002nre.2	-	4	1621	c.1508C>T	c.(1507-1509)TCA>TTA	p.S503L	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.S471L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	503	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTAAGGGTTGAGGATTGCCT	0.368		NA											11	31					0	0	0	0
SLC7A10	56301	broad.mit.edu	37	19	33699842	33699842	+	Silent	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:33699842T>G	uc002num.2	-	11	1674	c.1527A>C	c.(1525-1527)CCA>CCC	p.P509P	SLC7A10_uc002nul.2_Silent_p.P356P	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	509					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GCAGGGAGGGTGGGCAGGGGC	0.547		NA											10	70					0	0	0	0
NPHS1	4868	broad.mit.edu	37	19	36335330	36335330	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:36335330C>T	uc002oby.2	-	15	1962	c.1962G>A	c.(1960-1962)CTG>CTA	p.L654L		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	654	Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGTCACCACCAGCACCTGCT	0.537		NA											3	3					0	0	0	0
CYP2F1	1572	broad.mit.edu	37	19	41630665	41630665	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:41630665C>T	uc002opu.1	+	8	1062	c.1006C>T	c.(1006-1008)CGG>TGG	p.R336W	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Silent_p.R316R|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	336					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GGGACGCGCGCGGCTGCCGGC	0.677		NA											10	6					0	0	0	0
MAMSTR	284358	broad.mit.edu	37	19	49216571	49216571	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:49216571C>G	uc002pkg.2	-	10	1263	c.1201G>C	c.(1201-1203)GAC>CAC	p.D401H	MAMSTR_uc002pkf.2_Missense_Mutation_p.D298H	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	401	Ser-rich.|Transcription activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						CTGCTGGAGTCAGATAAGTCA	0.617		NA									OREG0025608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	17					0	0	0	0
LILRB4	11006	broad.mit.edu	37	19	55179342	55179342	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:55179342C>T	uc002qgp.2	+	12	1581	c.1219C>T	c.(1219-1221)CCC>TCC	p.P407S	LILRB4_uc002qgq.2_Missense_Mutation_p.P406S|LILRB4_uc002qgr.2_Missense_Mutation_p.P449S|LILRB4_uc010ert.2_Missense_Mutation_p.P448S|LILRB4_uc010eru.2_Missense_Mutation_p.P437S	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	407	Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		ATCTGAAGCCCCCCAGGATGT	0.647		NA											4	98					0	0	0	0
ZNF446	55663	broad.mit.edu	37	19	58988810	58988810	+	Silent	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:58988810G>C	uc002qsz.2	+	2	342	c.225G>C	c.(223-225)CTG>CTC	p.L75L	ZNF446_uc002qta.2_Silent_p.L75L|ZNF446_uc010eur.2_Silent_p.L75L	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCAGTTCCTGGGCACACTGC	0.662		NA											28	45					0	0	0	0
TTC27	55622	broad.mit.edu	37	2	32927945	32927945	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:32927945A>G	uc002rom.2	+	10	1422	c.1191A>G	c.(1189-1191)AAA>AAG	p.K397K	TTC27_uc010ymx.1_Silent_p.K347K	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	397							protein binding			central_nervous_system(1)	1						AACTTGAGAAAGGAAGTACTC	0.438		NA											50	102					0	0	0	0
CEBPZ	10153	broad.mit.edu	37	2	37455847	37455847	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:37455847T>C	uc002rpz.2	-	2	519	c.489A>G	c.(487-489)AAA>AAG	p.K163K	C2orf56_uc010ynj.1_5'Flank|C2orf56_uc002rqa.3_5'Flank|C2orf56_uc002rqc.3_5'Flank|C2orf56_uc010ynk.1_5'Flank|C2orf56_uc010ynl.1_5'Flank	NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	163					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				AGATGTTCTGTTTATCTTTCT	0.373		NA											50	70					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44079515	44079515	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:44079515T>C	uc002rtq.2	+	5	674	c.584T>C	c.(583-585)CTG>CCG	p.L195P	ABCG8_uc010yoa.1_Missense_Mutation_p.L195P	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	195	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATCGCGGAGCTGCGGCTTAGG	0.637		NA											24	31					0	0	0	0
OTX1	5013	broad.mit.edu	37	2	63283274	63283274	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:63283274T>C	uc002scd.2	+	5	1136	c.888T>C	c.(886-888)CAT>CAC	p.H296H	OTX1_uc010ypt.1_Silent_p.H230H	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	296	His-rich.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					accaccaccatcaccaccacc	0.537		NA											3	61					0	0	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98165918	98165918	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:98165918C>G	uc010yvc.1	-	20	1721	c.1441G>C	c.(1441-1443)GCC>CCC	p.A481P	ANKRD36B_uc010yve.1_RNA	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	481											0						TTTTCTCTGGCTATATTCAAA	0.303		NA											3	36					0	0	0	0
MRPS9	64965	broad.mit.edu	37	2	105696507	105696507	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:105696507A>T	uc002tcn.3	+	5	544	c.476A>T	c.(475-477)TAT>TTT	p.Y159F		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	159					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CAGTCATACTATTCATTAATG	0.333		NA											38	60					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141128783	141128783	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141128783T>A	uc002tvj.1	-	70	11812	c.10840A>T	c.(10840-10842)AAT>TAT	p.N3614Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3614	Extracellular (Potential).|LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTCTCCATTACATTTCAAA	0.294		NA								TSP Lung(27;0.18)			17	21					0	0	0	0
TANC1	85461	broad.mit.edu	37	2	160053172	160053172	+	Silent	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160053172G>T	uc002uag.2	+	18	3307	c.3033G>T	c.(3031-3033)CGG>CGT	p.R1011R	TANC1_uc010zcm.1_Silent_p.R1003R|TANC1_uc010fom.1_Silent_p.R817R|TANC1_uc010fon.2_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1011	ANK 4.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GTGCCCTACGGGGCCACGGTG	0.622		NA											25	53					2.24e-21	2.93e-21	1	0
WDSUB1	151525	broad.mit.edu	37	2	160139519	160139519	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160139519G>C	uc002uaj.3	-	2	211	c.62C>G	c.(61-63)TCC>TGC	p.S21C	WDSUB1_uc002uak.3_Missense_Mutation_p.S21C|WDSUB1_uc002ual.3_Missense_Mutation_p.S21C|WDSUB1_uc002uam.3_Missense_Mutation_p.S21C|WDSUB1_uc010foo.2_Missense_Mutation_p.S21C	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	21	WD 1.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						GAGGGAAAAGGAGAAGGCACA	0.413		NA											38	42					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170129520	170129520	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170129520T>C	uc002ues.2	-	15	2246	c.2033A>G	c.(2032-2034)CAC>CGC	p.H678R	LRP2_uc010zdf.1_Missense_Mutation_p.H609R	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	678	EGF-like 3.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCTGTTCTGTGGCTGAGGAC	0.453		NA											57	100					0	0	0	0
FASTKD1	79675	broad.mit.edu	37	2	170428349	170428349	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170428349G>C	uc002uev.3	-	2	579	c.191C>G	c.(190-192)TCA>TGA	p.S64*	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Nonsense_Mutation_p.S50*|FASTKD1_uc002uey.2_Nonsense_Mutation_p.S50*	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	64					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TTGCTTTTCTGAAAGTATGGC	0.378		NA											30	46					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227924929	227924929	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:227924929G>T	uc010zlt.1	-	27	2741	c.2087C>A	c.(2086-2088)GCC>GAC	p.A696D		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	696	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CAGCCCAGGGGCACCTTGGGG	0.428		NA											36	88					2.1e-21	2.75e-21	1	0
DIS3L2	129563	broad.mit.edu	37	2	233075076	233075076	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:233075076G>T	uc010fxz.2	+	10	1441	c.1165G>T	c.(1165-1167)GAC>TAC	p.D389Y	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	389							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AACCGCCCGAGACCTCGATGA	0.478		NA											16	75					6.5e-13	8.32e-13	1	0
CDC25B	994	broad.mit.edu	37	20	3782640	3782640	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:3782640C>G	uc002wjn.2	+	10	1769	c.991C>G	c.(991-993)CCC>GCC	p.P331A	CDC25B_uc010zqk.1_Missense_Mutation_p.P267A|CDC25B_uc010zql.1_Missense_Mutation_p.P253A|CDC25B_uc010zqm.1_Missense_Mutation_p.P240A|CDC25B_uc002wjl.2_Missense_Mutation_p.P219A|CDC25B_uc002wjm.2_Missense_Mutation_p.P219A|CDC25B_uc002wjo.2_Missense_Mutation_p.P317A|CDC25B_uc002wjp.2_Missense_Mutation_p.P290A|CDC25B_uc002wjq.2_Missense_Mutation_p.P131A|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	331					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						CGTGATCCGGCCCATCCTCAA	0.652		NA											3	12					0	0	0	0
AHCY	191	broad.mit.edu	37	20	32879320	32879320	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:32879320C>T	uc002xai.2	-	5	602	c.463G>A	c.(463-465)GAG>AAG	p.E155K	AHCY_uc002xaj.2_Missense_Mutation_p.E127K	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	155					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0						GTGGTCTCCTCAGAGATGCCT	0.468		NA											30	88					0	0	0	0
PCIF1	63935	broad.mit.edu	37	20	44571864	44571864	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:44571864A>G	uc002xqs.2	+	8	1116	c.802A>G	c.(802-804)ATG>GTG	p.M268V	PCIF1_uc002xqt.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	268						nucleus				skin(1)	1						TCGTGAAATCATGAACGACAT	0.537		NA											24	128					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10933918	10933918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:10933918C>A	uc002yip.1	-	17	1329	c.961G>T	c.(961-963)GAA>TAA	p.E321*	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Nonsense_Mutation_p.E303*|TPTE_uc002yir.1_Nonsense_Mutation_p.E283*|TPTE_uc010gkv.1_Nonsense_Mutation_p.E183*	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	321	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATTTACTTCCTTGGTGAAA	0.333		NA											51	315					1.48e-19	1.93e-19	1	0
PCNT	5116	broad.mit.edu	37	21	47817314	47817314	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:47817314G>A	uc002zji.3	+	22	4459	c.4352G>A	c.(4351-4353)CGC>CAC	p.R1451H	PCNT_uc002zjj.2_Missense_Mutation_p.R1333H	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1451	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TCTCAGCATCGCGGGTGTGCC	0.567		NA											29	23					0	0	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843615	22843615	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:22843615G>T	uc002zwc.1	-	4	885	c.109C>A	c.(109-111)CAT>AAT	p.H37N	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TCATTTACATGTTCCACACCA	0.418		NA											31	68					3.8e-20	4.97e-20	1	0
SLC2A11	66035	broad.mit.edu	37	22	24224830	24224830	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:24224830C>T	uc002zyn.3	+	7	969	c.870C>T	c.(868-870)GAC>GAT	p.D290D	SLC2A11_uc002zyl.1_Silent_p.D297D|SLC2A11_uc002zym.3_Silent_p.D297D|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Silent_p.D297D|SLC2A11_uc002zyp.3_Silent_p.D293D	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	290	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GCGGGAATGACTCGGTGAGAC	0.687		NA											4	15					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26159338	26159338	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26159338C>T	uc003abz.1	+	3	430	c.180C>T	c.(178-180)GTC>GTT	p.V60V	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	60						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGTTAGCTGTCGCCTCTCCAG	0.512		NA											13	13					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26423316	26423316	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26423316G>C	uc003abz.1	+	43	7626	c.7376G>C	c.(7375-7377)GGA>GCA	p.G2459A	MYO18B_uc003aca.1_Missense_Mutation_p.G2340A|MYO18B_uc010guy.1_Missense_Mutation_p.G2341A|MYO18B_uc010guz.1_Missense_Mutation_p.G2339A|MYO18B_uc011aka.1_Missense_Mutation_p.G1613A|MYO18B_uc011akb.1_Missense_Mutation_p.G1972A|MYO18B_uc010gva.1_Missense_Mutation_p.G442A|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2459						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCCTTGGCTGGATCAGCCAAA	0.532		NA											56	83					0	0	0	0
MIOX	55586	broad.mit.edu	37	22	50926457	50926457	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:50926457G>A	uc003bll.1	+	4	434	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	MIOX_uc003blm.1_Missense_Mutation_p.R107Q|MIOX_uc003bln.1_Missense_Mutation_p.R107Q	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	107					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGGCATCCGGAAGGCCCAC	0.652		NA											15	46					0	0	0	0
OGG1	4968	broad.mit.edu	37	3	9798304	9798304	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:9798304G>A	uc003bsi.2	+	5	1240	c.897G>A	c.(895-897)CTG>CTA	p.L299L	OGG1_uc003bsh.2_Silent_p.L299L|OGG1_uc003bsj.2_Silent_p.L299L|OGG1_uc003bsk.2_Silent_p.L299L|OGG1_uc003bsl.2_Silent_p.L299L|OGG1_uc003bsm.2_Silent_p.L299L|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Silent_p.L64L|OGG1_uc010hcm.1_Intron|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Silent_p.L64L	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	299					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					ACAAGGAACTGGGTGAGGAAA	0.582		NA						BER_DNA_glycosylases					27	8					0	0	0	0
IMPDH2	3615	broad.mit.edu	37	3	49064207	49064207	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:49064207C>T	uc003cvt.2	-	7	824	c.732G>A	c.(730-732)CTG>CTA	p.L244L		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	244					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCCCACACAGCAGCTGTTTCT	0.517		NA											113	40					0	0	0	0
EPHA6	285220	broad.mit.edu	37	3	97202882	97202882	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:97202882A>T	uc010how.1	+	10	2222	c.2179A>T	c.(2179-2181)ATT>TTT	p.I727F	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.I93F|EPHA6_uc003drs.3_Missense_Mutation_p.I119F|EPHA6_uc003drr.3_Missense_Mutation_p.I119F|EPHA6_uc003drt.2_Missense_Mutation_p.I119F|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	632	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						AAGAATTCGTATTGAGAGAGT	0.264		NA											21	20					0	0	0	0
POLQ	10721	broad.mit.edu	37	3	121202255	121202255	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:121202255T>A	uc003eee.3	-	18	6077	c.5948A>T	c.(5947-5949)GAG>GTG	p.E1983V	POLQ_uc003eed.2_Missense_Mutation_p.E1155V	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1983					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ATAACTTTGCTCCAAGGAGAT	0.303		NA						DNA_polymerases_(catalytic_subunits)					27	30					0	0	0	0
PIK3R4	30849	broad.mit.edu	37	3	130452572	130452572	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:130452572G>A	uc003enj.2	-	4	1851	c.1270C>T	c.(1270-1272)CAT>TAT	p.H424Y		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	424	HEAT 1.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTGCTGAAATGCAAAAGATAT	0.413		NA											43	45					0	0	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135863925	135863925	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:135863925G>C	uc003eqv.1	+	14	3935	c.3370G>C	c.(3370-3372)GAA>CAA	p.E1124Q	PPP2R3A_uc011blz.1_Missense_Mutation_p.E388Q|PPP2R3A_uc003eqw.1_Missense_Mutation_p.E503Q	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	1124					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CTCTCCCTCTGAATTTGGAAA	0.358		NA											3	44					0	0	0	0
XRN1	54464	broad.mit.edu	37	3	142048418	142048418	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:142048418T>C	uc003eus.2	-	37	4326	c.4259A>G	c.(4258-4260)CAT>CGT	p.H1420R	XRN1_uc010huu.2_Missense_Mutation_p.H887R|XRN1_uc003eut.2_Missense_Mutation_p.H1420R|XRN1_uc003euu.2_Missense_Mutation_p.H1421R	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1420					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CTGAACATTATGGTACTCATT	0.383		NA											26	26					0	0	0	0
SPATA18	132671	broad.mit.edu	37	4	52943055	52943055	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:52943055G>T	uc003gzl.2	+	7	1147	c.869G>T	c.(868-870)CGC>CTC	p.R290L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.R258L|SPATA18_uc003gzk.1_Missense_Mutation_p.R290L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	290	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCCCAAACCGCTCCAAGCTG	0.682		NA											15	28					0.000566183	0.000663279	1	0
PRDM8	56978	broad.mit.edu	37	4	81123531	81123531	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81123531C>T	uc010ijo.2	+	8	1754	c.915C>T	c.(913-915)ATC>ATT	p.I305I	PRDM8_uc003hmb.3_Silent_p.I305I|PRDM8_uc003hmc.3_Silent_p.I305I	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	305	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCGACGGCATCGCCACGGGCG	0.607		NA									OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0	0	0	0
FGF5	2250	broad.mit.edu	37	4	81188009	81188009	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81188009T>C	uc003hmd.2	+	1	268	c.31T>C	c.(31-33)TTC>CTC	p.F11L	FGF5_uc003hme.2_Missense_Mutation_p.F11L	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	11					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						CCTCCTCTTCTTCAGCCACCT	0.622		NA											32	42					0	0	0	0
HNRPDL	9987	broad.mit.edu	37	4	83350560	83350560	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:83350560A>G	uc003hmr.2	-	1	819	c.284T>C	c.(283-285)ATA>ACA	p.I95T	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.I95T	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	95					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				GGAGCGTTGTATGGAGCTGGA	0.667		NA											19	50					0	0	0	0
C4orf36	132989	broad.mit.edu	37	4	87809368	87809368	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:87809368G>C	uc003hqe.3	-	3	439	c.126C>G	c.(124-126)ATC>ATG	p.I42M		NM_144645	NP_653246	Q96KX1	CD036_HUMAN	hypothetical protein LOC132989	42											0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00141)		AAGGCAACTTGATATTGGCTA	0.378		NA											24	29					0	0	0	0
MAML3	55534	broad.mit.edu	37	4	140811147	140811147	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:140811147G>A	uc003ihz.1	-	2	2195	c.1443C>T	c.(1441-1443)CTC>CTT	p.L481L	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	481	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					tctgctgcATGAGTTTGGCCC	0.313		NA											13	24					0	0	0	0
INPP4B	8821	broad.mit.edu	37	4	143094803	143094803	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:143094803T>G	uc003iix.3	-	17	1936	c.1341A>C	c.(1339-1341)TTA>TTC	p.L447F	INPP4B_uc003iiw.3_Missense_Mutation_p.L447F|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.L262F|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.L318F	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	447					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					AAAGCATCTTTAAAGAATTCT	0.388		NA											26	60					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247297	153247297	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:153247297G>A	uc003ims.2	-	10	1654	c.1505C>T	c.(1504-1506)GCA>GTA	p.A502V	FBXW7_uc011cii.1_Missense_Mutation_p.A502V|FBXW7_uc003imt.2_Missense_Mutation_p.A502V|FBXW7_uc011cih.1_Missense_Mutation_p.A326V|FBXW7_uc003imq.2_Missense_Mutation_p.A422V|FBXW7_uc003imr.2_Missense_Mutation_p.A384V	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	502	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GCGGACTGCTGCAACATGACC	0.468		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								41	53					0	0	0	0
STOX2	56977	broad.mit.edu	37	4	184931650	184931650	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:184931650G>T	uc003ivz.1	+	3	3094	c.1659G>T	c.(1657-1659)GAG>GAT	p.E553D	STOX2_uc003iwa.1_Missense_Mutation_p.E242D	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	553					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		GCTATAAAGAGGTGTGTATTC	0.522		NA											18	15					3.53e-06	4.28e-06	1	0
TLR3	7098	broad.mit.edu	37	4	187004613	187004613	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187004613C>T	uc003iyq.2	+	4	1874	c.1773C>T	c.(1771-1773)ATC>ATT	p.I591I	TLR3_uc011ckz.1_Silent_p.I314I|TLR3_uc003iyr.2_Silent_p.I314I	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	591	LRR 21.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TAAAGATCATCGATTTAGGAT	0.388		NA											30	45					0	0	0	0
TLR3	7098	broad.mit.edu	37	4	187006008	187006008	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187006008C>G	uc003iyq.2	+	5	2797	c.2696C>G	c.(2695-2697)TCC>TGC	p.S899C	TLR3_uc011ckz.1_Missense_Mutation_p.S622C|TLR3_uc003iyr.2_Missense_Mutation_p.S622C	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	899	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GCACTTGGATCCAAAAACTCT	0.328		NA											26	26					0	0	0	0
ZFP42	132625	broad.mit.edu	37	4	188924382	188924382	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:188924382C>G	uc003izg.1	+	3	666	c.421C>G	c.(421-423)CTT>GTT	p.L141V	ZFP42_uc003izh.1_Missense_Mutation_p.L141V|ZFP42_uc003izi.1_Missense_Mutation_p.L141V	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	141					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGAGAATTCGCTTGAGTATTC	0.418		NA											50	88					0	0	0	0
ZDHHC11	79844	broad.mit.edu	37	5	837492	837492	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:837492T>C	uc011cma.1	-	6	1272	c.888A>G	c.(886-888)AAA>AAG	p.K296K	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	296						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGAGAACTCCTTTGTCCATTT	0.478		NA											9	301					0	0	0	0
SLC45A2	51151	broad.mit.edu	37	5	33984637	33984637	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:33984637C>G	uc003jid.2	-	1	144	c.52G>C	c.(52-54)GAT>CAT	p.D18H	SLC45A2_uc003jie.2_Missense_Mutation_p.D18H|SLC45A2_uc003jif.3_Missense_Mutation_p.D18H|SLC45A2_uc011coe.1_Missense_Mutation_p.D18H	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	18	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGGCCATCATCAGCTAGGGAT	0.582		NA											18	58					0	0	0	0
POLK	51426	broad.mit.edu	37	5	74865317	74865317	+	Silent	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:74865317G>T	uc003kdw.2	+	4	504	c.408G>T	c.(406-408)CTG>CTT	p.L136L	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kdz.2_Silent_p.L136L|POLK_uc003kea.2_Silent_p.L136L|POLK_uc003keb.2_Silent_p.L136L|POLK_uc010izq.2_Silent_p.L136L|POLK_uc003kec.2_Silent_p.L46L|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Silent_p.L46L|POLK_uc003kee.2_Silent_p.L136L|POLK_uc003kef.2_Silent_p.L46L	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	136	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGAGTATGCTGGTAAGTAAAG	0.328		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					16	11					1.34e-09	1.69e-09	1	0
CMYA5	202333	broad.mit.edu	37	5	79033128	79033128	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:79033128C>G	uc003kgc.2	+	2	8612	c.8540C>G	c.(8539-8541)ACA>AGA	p.T2847R		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2847						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAAGGCATACAGTTCATACT	0.423		NA											41	25					0	0	0	0
RGMB	285704	broad.mit.edu	37	5	98129212	98129212	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:98129212C>G	uc003knc.2	+	5	1594	c.1192C>G	c.(1192-1194)CAA>GAA	p.Q398E		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	357					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TGCCAACACTCAATGCCATGA	0.587		NA											9	11					0	0	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574507	140574507	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140574507C>T	uc003lix.2	+	1	2556	c.2382C>T	c.(2380-2382)AGC>AGT	p.S794S		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	794	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGAAATAGCTTTGGATTTA	0.368		NA											17	36					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580775	140580775	+	Silent	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140580775A>C	uc003liy.2	+	1	1428	c.1428A>C	c.(1426-1428)ACA>ACC	p.T476T	PCDHB11_uc011daj.1_Silent_p.T111T	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	476	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGCGCTACAGACAGAGACT	0.617		NA											41	207					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719966	140719966	+	Silent	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140719966C>A	uc003ljk.1	+	1	1613	c.1428C>A	c.(1426-1428)GCC>GCA	p.A476A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.A476A	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	476	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGACGGCCCATGACCCCG	0.542		NA											21	86					4.43e-23	5.83e-23	1	0
ARAP3	64411	broad.mit.edu	37	5	141059694	141059694	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:141059694G>A	uc003llm.2	-	2	438	c.360C>T	c.(358-360)CTC>CTT	p.L120L	ARAP3_uc003lln.2_Silent_p.L42L|ARAP3_uc003llo.1_Silent_p.L120L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	120	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTGGTCCCCCGAGGGCTGGGC	0.652		NA											105	41					0	0	0	0
HFE	3077	broad.mit.edu	37	6	26091716	26091716	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:26091716A>G	uc003nfx.1	+	3	675	c.515A>G	c.(514-516)CAC>CGC	p.H172R	HFE_uc003nfy.1_Missense_Mutation_p.H149R|HFE_uc010jqe.1_Missense_Mutation_p.H172R|HFE_uc003nfz.1_Missense_Mutation_p.H84R|HFE_uc003ngd.1_Missense_Mutation_p.H84R|HFE_uc003nga.1_Missense_Mutation_p.H172R|HFE_uc003ngb.1_Intron|HFE_uc003ngc.1_Intron|HFE_uc003nge.1_Intron|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	172	Alpha-2.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						TGGGAAAGGCACAAGATTCGG	0.597		NA							Hemochromatosis				12	33					0	0	0	0
RGL2	5863	broad.mit.edu	37	6	33264552	33264552	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:33264552A>C	uc003odv.2	-	4	375	c.242T>G	c.(241-243)GTC>GGC	p.V81G	RGL2_uc003odu.2_5'Flank|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_5'UTR|RGL2_uc011drb.1_5'UTR	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	81					Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						AGGCATAGGGACCTGGAGAAC	0.562		NA											21	31					0	0	0	0
MRPS10	55173	broad.mit.edu	37	6	42179587	42179587	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:42179587C>G	uc003osa.3	-	4	301	c.255G>C	c.(253-255)AAG>AAC	p.K85N	MRPS10_uc011dup.1_Missense_Mutation_p.K44N	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	85					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CCAATACAGCCTTATCGTGAC	0.388		NA											11	31					0	0	0	0
TDRD6	221400	broad.mit.edu	37	6	46658086	46658086	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:46658086A>G	uc003oyj.2	+	1	2221	c.2221A>G	c.(2221-2223)AAA>GAA	p.K741E	TDRD6_uc010jze.2_Missense_Mutation_p.K735E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	741					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TGTGCAGGAAAAAGTGAAAAG	0.393		NA											10	12					0	0	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791426	50791426	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:50791426C>A	uc003pag.2	+	2	554	c.388C>A	c.(388-390)CCC>ACC	p.P130T		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	130	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GGCCGCCTTGCCCCAGCTCTC	0.721		NA											7	5					0.00307968	0.00356809	1	0
LYRM2	57226	broad.mit.edu	37	6	90347471	90347471	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90347471G>A	uc003pnm.2	-	2	215	c.176C>T	c.(175-177)GCC>GTC	p.A59V	LYRM2_uc010kce.1_RNA|LYRM2_uc003png.2_RNA|LYRM2_uc010kcf.1_RNA|LYRM2_uc010kcg.2_RNA|LYRM2_uc003pnl.3_RNA	NM_020466	NP_065199	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	59											0		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		CTCTTCGGTGGCACTTTTGTT	0.363		NA											5	221					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90409446	90409446	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90409446T>A	uc003pnn.1	-	58	8987	c.8871A>T	c.(8869-8871)AGA>AGT	p.R2957S		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2957					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTGCTGCATCTGTTCCAAA	0.408		NA											31	38					0	0	0	0
RSPH4A	345895	broad.mit.edu	37	6	116953560	116953560	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:116953560G>A	uc003pxe.2	+	6	2252	c.2107G>A	c.(2107-2109)GAA>AAA	p.E703K	RSPH4A_uc010kee.2_3'UTR	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	703					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						AGCTGAGAATGAAGAATCTGA	0.428		NA							Kartagener_syndrome				13	24					0	0	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597187	136597187	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:136597187T>C	uc003qgx.1	-	5	1729	c.1476A>G	c.(1474-1476)AAA>AAG	p.K492K	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Silent_p.K490K|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.K490K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	492					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ACTGAGTTTCTTTCTTTACTG	0.378		NA											31	201					0	0	0	0
ARID1B	57492	broad.mit.edu	37	6	157522507	157522507	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:157522507C>T	uc003qqn.2	+	18	4877	c.4725C>T	c.(4723-4725)ACC>ACT	p.T1575T	ARID1B_uc003qqo.2_Silent_p.T1535T|ARID1B_uc003qqp.2_Silent_p.T1522T	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1580	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCAGGTCACCGGGCCACCAC	0.547		NA											45	130					0	0	0	0
CDK13	8621	broad.mit.edu	37	7	40027286	40027286	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:40027286C>T	uc003thh.3	+	2	1582	c.1300C>T	c.(1300-1302)CGT>TGT	p.R434C	CDK13_uc003thi.3_Missense_Mutation_p.R434C|CDK13_uc011kbf.1_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	434					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						ATCCAGAAGTCGTCATTCTAG	0.378		NA											25	33					0	0	0	0
STEAP2	261729	broad.mit.edu	37	7	89859238	89859238	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:89859238A>G	uc003ujz.2	+	4	1466	c.1073A>G	c.(1072-1074)GAA>GGA	p.E358G	STEAP2_uc010len.2_Missense_Mutation_p.E358G|STEAP2_uc003uka.2_Missense_Mutation_p.E358G|STEAP2_uc003ukb.2_Missense_Mutation_p.E358G|STEAP2_uc003ukc.2_Missense_Mutation_p.E358G|STEAP2_uc003ukd.2_Missense_Mutation_p.E358G	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	358	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					TGGAGAATTGAAATGTATATC	0.373		NA											3	126					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100348484	100348484	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:100348484G>A	uc003uwj.2	+	12	1651	c.1486G>A	c.(1486-1488)GTC>ATC	p.V496I	ZAN_uc003uwk.2_Missense_Mutation_p.V496I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	496	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAACACCTCCGTCACCGTCCC	0.632		NA											13	64					0	0	0	0
TRYX3	136541	broad.mit.edu	37	7	141955074	141955074	+	Silent	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:141955074C>A	uc003vxb.2	-	3	557	c.237G>T	c.(235-237)CTG>CTT	p.L79L	TRYX3_uc003vxc.3_Silent_p.L79L	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					CAATCACTTGCAGATGCTTTT	0.413		NA											36	16					3.76e-14	4.86e-14	1	0
MLL3	58508	broad.mit.edu	37	7	151921619	151921619	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:151921619C>A	uc003wla.2	-	19	3278	c.3059G>T	c.(3058-3060)GGA>GTA	p.G1020V	MLL3_uc003wkz.2_Missense_Mutation_p.G81V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1020	PHD-type 5.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAGGAGTCTTCCTGGGTCAGT	0.488		NA	N		medulloblastoma								13	13					0.00400662	0.00463183	1	0
PRKDC	5591	broad.mit.edu	37	8	48697813	48697813	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:48697813G>A	uc003xqi.2	-	78	11025	c.10968C>T	c.(10966-10968)CTC>CTT	p.L3656L	PRKDC_uc003xqj.2_Silent_p.L3656L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3656					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGAAGTCACTGAGCTTCATTC	0.363		NA						NHEJ					12	33					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73480238	73480238	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:73480238A>G	uc003xzb.2	+	2	857	c.269A>G	c.(268-270)GAT>GGT	p.D90G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	90	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TATTTCTTTGATCGGCATCCA	0.493		NA											33	91					0	0	0	0
JPH1	56704	broad.mit.edu	37	8	75233253	75233253	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:75233253G>C	uc003yae.2	-	1	310	c.270C>G	c.(268-270)TTC>TTG	p.F90L	JPH1_uc003yaf.2_Missense_Mutation_p.F90L|JPH1_uc003yag.1_Intron	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	90	Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGCGCCCCTTGAAACCATGTG	0.667		NA											9	52					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764911	77764911	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:77764911T>C	uc003yav.2	+	10	6006	c.5619T>C	c.(5617-5619)TTT>TTC	p.F1873F	ZFHX4_uc003yau.1_Silent_p.F1918F|ZFHX4_uc003yaw.1_Silent_p.F1873F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1873						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTTGGTTTTGAACTGGTCA	0.448		NA								HNSCC(33;0.089)			13	47					0	0	0	0
WWP1	11059	broad.mit.edu	37	8	87414410	87414410	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:87414410A>G	uc003ydt.2	+	8	982	c.702A>G	c.(700-702)GCA>GCG	p.A234A	WWP1_uc010mai.2_Intron	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	234					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						AACCACTCGCATCTGAGCCTG	0.448		NA											15	27					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92983007	92983007	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:92983007C>T	uc003yfd.2	-	10	1502	c.1418G>A	c.(1417-1419)CGG>CAG	p.R473Q	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R446Q|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R436Q|RUNX1T1_uc010mao.2_Missense_Mutation_p.R446Q|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R484Q|RUNX1T1_uc010man.1_Missense_Mutation_p.R98Q|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R436Q	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	473					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTGGGCTTTCCGCTCCGCCTC	0.617		NA											27	29					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110416786	110416786	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:110416786C>G	uc003yne.2	+	15	1481	c.1377C>G	c.(1375-1377)TAC>TAG	p.Y459*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	459	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTCCAGATACTATATTGAAA	0.299		NA								HNSCC(38;0.096)			9	16					0	0	0	0
ENPP2	5168	broad.mit.edu	37	8	120596204	120596204	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:120596204G>A	uc003yot.1	-	16	1539	c.1453C>T	c.(1453-1455)CAG>TAG	p.Q485*	ENPP2_uc011lic.1_Nonsense_Mutation_p.Q2*|ENPP2_uc003yor.1_Nonsense_Mutation_p.Q124*|ENPP2_uc003yos.1_Nonsense_Mutation_p.Q537*|ENPP2_uc010mdd.1_Nonsense_Mutation_p.Q485*	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	485					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATCATACCTGCATGCTGTTG	0.363		NA											81	249					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139160898	139160898	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:139160898C>G	uc003yuy.2	-	14	3484	c.3313G>C	c.(3313-3315)GAA>CAA	p.E1105Q	FAM135B_uc003yux.2_Missense_Mutation_p.E1006Q|FAM135B_uc003yuz.2_Intron|FAM135B_uc003yva.2_Missense_Mutation_p.E667Q|FAM135B_uc003yvb.2_Intron	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1105										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCTTCAGTTCTTTTTTAAAT	0.368		NA								HNSCC(54;0.14)			10	55					0	0	0	0
NAPRT1	93100	broad.mit.edu	37	8	144658617	144658617	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:144658617C>T	uc003yym.3	-	7	1032	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q	NAPRT1_uc003yyn.3_Missense_Mutation_p.R336Q|NAPRT1_uc011lkh.1_Missense_Mutation_p.R336Q|NAPRT1_uc003yyo.3_Missense_Mutation_p.R336Q	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	336					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGCAGCAGCTCGGAAGACCTT	0.652		NA											18	40					0	0	0	0
KIFC2	90990	broad.mit.edu	37	8	145698668	145698668	+	Silent	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:145698668G>T	uc003zcz.2	+	17	2417	c.2352G>T	c.(2350-2352)CCG>CCT	p.P784P	KIFC2_uc003zda.2_Silent_p.P172P	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	784	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TCCGCTCACCGGGACCCCCTG	0.741		NA											7	16					0.000157383	0.000186031	1	0
KIAA1432	57589	broad.mit.edu	37	9	5774097	5774097	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:5774097G>A	uc003zji.2	+	25	3979	c.3886G>A	c.(3886-3888)GAG>AAG	p.E1296K	KIAA1432_uc003zjl.3_Missense_Mutation_p.E1259K|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1375						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCCCCGGGCAGAGGAGAGCAG	0.557		NA											19	19					0	0	0	0
DENND1A	57706	broad.mit.edu	37	9	126414381	126414381	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:126414381C>G	uc004bnz.1	-	9	762	c.529G>C	c.(529-531)GTG>CTG	p.V177L	DENND1A_uc011lzl.1_5'UTR|DENND1A_uc004bny.1_5'UTR|DENND1A_uc011lzm.1_Missense_Mutation_p.V145L|DENND1A_uc004boa.1_Missense_Mutation_p.V177L|DENND1A_uc004bob.1_Missense_Mutation_p.V147L|DENND1A_uc004boc.2_Missense_Mutation_p.V145L	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	177	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCACAGCCACAAAATATTCT	0.398		NA											16	45					0	0	0	0
GTF3C4	9329	broad.mit.edu	37	9	135546192	135546192	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:135546192G>A	uc010mzv.2	+	1	465	c.207G>A	c.(205-207)CCG>CCA	p.P69P	DDX31_uc004cbq.1_5'Flank|DDX31_uc010mzu.1_5'Flank|DDX31_uc004cbr.1_5'Flank|DDX31_uc004cbs.1_5'Flank|GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	69					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCCTGGAACCGCTGGCTTGGT	0.706		NA											4	4					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412684	139412684	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:139412684C>T	uc004chz.2	-	7	1160	c.1160G>A	c.(1159-1161)TGC>TAC	p.C387Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	387	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTTGGTGTCGCAGTTGGAGCC	0.672		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	1					0	0	0	0
MRPL41	64975	broad.mit.edu	37	9	140446808	140446808	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:140446808T>G	uc004cnh.3	+	2	405	c.275T>G	c.(274-276)TTC>TGC	p.F92C	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	92					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGCAGCTCTTCAGCGAAGCC	0.622		NA											13	29					0	0	0	0
MXRA5	25878	broad.mit.edu	37	X	3241328	3241328	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:3241328C>T	uc004crg.3	-	5	2555	c.2398G>A	c.(2398-2400)GAA>AAA	p.E800K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	800						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGGGTACTTCTGTGCCCTTA	0.468		NA											27	16					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12701691	12701691	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:12701691C>T	uc004cuz.1	+	6	1064	c.558C>T	c.(556-558)ATC>ATT	p.I186I	FRMPD4_uc011mij.1_Silent_p.I178I	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	186					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGTCATCATCAACGGCCAAG	0.443		NA											19	8					0	0	0	0
GPR64	10149	broad.mit.edu	37	X	19022962	19022962	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:19022962C>A	uc004cyx.2	-	23	2039	c.1875G>T	c.(1873-1875)ATG>ATT	p.M625I	GPR64_uc004cyy.2_Missense_Mutation_p.M622I|GPR64_uc004cyz.2_Missense_Mutation_p.M611I|GPR64_uc004czb.2_Missense_Mutation_p.M625I|GPR64_uc004czc.2_Missense_Mutation_p.M609I|GPR64_uc004czd.2_Missense_Mutation_p.M601I|GPR64_uc004cze.2_Missense_Mutation_p.M595I|GPR64_uc004czf.2_Missense_Mutation_p.M587I|GPR64_uc004cza.2_Missense_Mutation_p.M603I|GPR64_uc004cyw.2_Missense_Mutation_p.M609I|GPR64_uc010nfj.2_Missense_Mutation_p.M506I	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	625	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TCAGAGCCATCATTTGAGCAG	0.333		NA											84	31					1.8e-35	2.38e-35	1	0
P2RY10	27334	broad.mit.edu	37	X	78216656	78216656	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:78216656C>T	uc004ede.2	+	4	1008	c.639C>T	c.(637-639)ATC>ATT	p.I213I	P2RY10_uc004edf.2_Silent_p.I213I	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	213	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAGTGATCATCATCGCATGGT	0.478		NA											38	13					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107977584	107977584	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:107977584G>A	uc004eoc.2	-	1	2024	c.1991C>T	c.(1990-1992)ACG>ATG	p.T664M		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	664						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCATTCTTTCGTGGCTCCTCT	0.512		NA											219	77					0	0	0	0
ZMYM6	9204	broad.mit.edu	37	1	35452758	35452759	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:35452758_35452759insA	uc001byh.2	-	16	4152_4153	c.3924_3925insT	c.(3922-3927)CTTGCAfs	p.L1308fs	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Frame_Shift_Ins_p.L1211fs	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1308_1309					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GATGTGACTGCAAGTCTTAGGG	0.366		NA											27	55	---	---	---	---	NA	NA	NA	NA
HEATR5A	25938	broad.mit.edu	37	14	31819914	31819915	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:31819914_31819915insA	uc001wrf.3	-	11	1618_1619	c.1541_1542insT	c.(1540-1542)ATAfs	p.I514fs	HEATR5A_uc010ami.2_Frame_Shift_Ins_p.I412fs|HEATR5A_uc001wrg.1_Frame_Shift_Ins_p.I396fs|HEATR5A_uc010tpk.1_Frame_Shift_Ins_p.I807fs	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	801							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GCTGTTCCAATATAAGAAGCCT	0.272		NA											6	10	---	---	---	---	NA	NA	NA	NA
CLK3	1198	broad.mit.edu	37	15	74919886	74919888	+	In_Frame_Del	DEL	GAG	GAG	-	rs149199059		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:74919886_74919888delGAG	uc010uln.1	+	9	1824_1826	c.1363_1365delGAG	c.(1363-1365)GAGdel	p.E456del	CLK3_uc002ayg.3_In_Frame_Del_p.E308del|CLK3_uc002ayh.3_In_Frame_Del_p.E87del|CLK3_uc002ayj.3_In_Frame_Del_p.E285del|CLK3_uc002ayk.3_In_Frame_Del_p.E235del|CLK3_uc002ayl.3_In_Frame_Del_p.E141del	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	456	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						TCAGAGCTGTGAGGAGAAGTCAG	0.576		NA											54	54	---	---	---	---	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	141122323	141122323	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141122323delG	uc002tvj.1	-	72	12010	c.11038delC	c.(11038-11040)CTTfs	p.L3680fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3680	Extracellular (Potential).|LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTGCAAAGGAACTCATCA	0.403		NA								TSP Lung(27;0.18)			46	112	---	---	---	---	NA	NA	NA	NA
C20orf103	24141	broad.mit.edu	37	20	9496163	9496180	+	In_Frame_Del	DEL	CTGAAAAAGATATATTTG	CTGAAAAAGATATATTTG	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:9496163_9496180delCTGAAAAAGATATATTTG	uc002wni.1	+	2	357_374	c.128_145delCTGAAAAAGATATATTTG	c.(127-147)CCTGAAAAAGATATATTTGTG>CTG	p.43_49PEKDIFV>L	C20orf103_uc010zrc.1_In_Frame_Del_p.43_49PEKDIFV>L	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	43_49	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			TCCACTAACCCTGAAAAAGATATATTTGTGGTGCGGGA	0.436		NA											24	96	---	---	---	---	NA	NA	NA	NA
SHROOM1	134549	broad.mit.edu	37	5	132161695	132161695	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:132161695delG	uc003kxx.2	-	4	943	c.138delC	c.(136-138)CGCfs	p.R46fs	SHROOM1_uc003kxy.1_Frame_Shift_Del_p.R46fs	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	46					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCGACTGCGTGCGCGGCTCGG	0.572		NA											2	4	---	---	---	---	NA	NA	NA	NA
HLA-A	3105	broad.mit.edu	37	6	29911958	29911959	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:29911958_29911959insGC	uc003nol.2	+	4	679_680	c.679_680insGC	c.(679-681)TGCfs	p.C227fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc003nok.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc003non.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc003noo.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc010jrr.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc003nom.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc010klp.2_Frame_Shift_Ins_p.C199fs|HLA-A_uc011dmc.1_Frame_Shift_Ins_p.C106fs|HLA-A_uc011dmd.1_Frame_Shift_Ins_p.C106fs	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	227	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CACCCTGAGGTGCTGGGCCCTG	0.604		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			37	120	---	---	---	---	NA	NA	NA	NA
PLEKHG1	57480	broad.mit.edu	37	6	151162005	151162006	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:151162005_151162006delGT	uc003qny.1	+	17	4443_4444	c.4131_4132delGT	c.(4129-4134)CAGTGTfs	p.Q1377fs	PLEKHG1_uc011eem.1_Frame_Shift_Del_p.Q1436fs	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1377_1378					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AAAAATTTCAGTGTCTCAGTTC	0.366		NA											13	94	---	---	---	---	NA	NA	NA	NA
