Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CRCT1	54544	broad.mit.edu	37	1	152487926	152487926	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152487926C>T	uc001ezz.2	+	2	140	c.67C>T	c.(67-69)CCG>TCG	p.P23S		NM_019060	NP_061933	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	23											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGccccgctccgtgtcccgc	0.473		NA											19	13					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196227545	196227545	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:196227545C>T	uc001gtd.1	-	26	3050	c.2990G>A	c.(2989-2991)CGC>CAC	p.R997H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R930H|KCNT2_uc001gtf.1_Missense_Mutation_p.R973H|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.R501H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	997	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TGTTGAGTTGCGGTGGTTGCT	0.483		NA											74	100					0	0	0	0
ARMC3	219681	broad.mit.edu	37	10	23270411	23270411	+	Missense_Mutation	SNP	C	C	G	rs146538646		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr10:23270411C>G	uc001irm.3	+	9	1142	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	ARMC3_uc010qcv.1_Missense_Mutation_p.F353L|ARMC3_uc010qcw.1_Missense_Mutation_p.F90L	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	353	ARM 9.						binding				0						AAGATTTTTTCAATAATCAGG	0.363		NA											57	62					0	0	0	0
AP2A2	161	broad.mit.edu	37	11	994108	994108	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:994108C>T	uc001lss.2	+	14	2000	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W	AP2A2_uc001lst.1_Missense_Mutation_p.R608W|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	607					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		ATTCCCGGAGCGGGAGTCCTC	0.622		NA											68	111					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1263410	1263410	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:1263410C>T	uc009ycr.1	+	47	7505	c.7379C>T	c.(7378-7380)ACG>ATG	p.T2460M	MUC5B_uc001ltb.2_Missense_Mutation_p.T1770M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1767	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGACAGAGACGACAATGAGC	0.617		NA											31	41					0	0	0	0
TMEM86A	144110	broad.mit.edu	37	11	18723189	18723189	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:18723189G>T	uc001moz.1	+	3	439	c.356G>T	c.(355-357)CGG>CTG	p.R119L		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	119						integral to membrane				ovary(1)	1						CTGGCTCTTCGGACAGGTCTG	0.612		NA											58	73					2.57e-57	2.94e-57	1	0
DAGLA	747	broad.mit.edu	37	11	61488167	61488167	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:61488167G>A	uc001nsa.2	+	3	223	c.112G>A	c.(112-114)GTG>ATG	p.V38M		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	38	Helical; (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GATCCTGTCCGTGGTGCTCTT	0.637		NA											48	60					0	0	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793355	65793355	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:65793355C>T	uc001ogt.2	-	1	634	c.496G>A	c.(496-498)GTG>ATG	p.V166M		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	166	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding	p.V166M(1)		ovary(2)	2						TGGTGGGGCACGCCAGAGGAA	0.582		NA											71	75					0	0	0	0
PKNOX2	63876	broad.mit.edu	37	11	125301145	125301145	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:125301145G>A	uc001qbu.2	+	13	1590	c.1276G>A	c.(1276-1278)GAT>AAT	p.D426N	PKNOX2_uc010saz.1_Missense_Mutation_p.D397N|PKNOX2_uc010sba.1_Missense_Mutation_p.D397N|PKNOX2_uc010sbb.1_Missense_Mutation_p.D362N|PKNOX2_uc001qbv.2_Missense_Mutation_p.D191N	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	426	Asp/Glu-rich (acidic).					nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		GGCTGCACACGATGACTCATT	0.388		NA											18	29					0	0	0	0
MAP3K12	7786	broad.mit.edu	37	12	53877172	53877172	+	Missense_Mutation	SNP	T	T	C	rs140537763		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:53877172T>C	uc001sdm.1	-	11	1573	c.1475A>G	c.(1474-1476)AAG>AGG	p.K492R	MAP3K12_uc001sdn.1_Missense_Mutation_p.K525R	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	492					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						CACATTCCTCTTCTTGATAAG	0.532		NA											127	162					0	0	0	0
ACTN1	87	broad.mit.edu	37	14	69349260	69349260	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:69349260G>A	uc001xkl.2	-	16	2178	c.1868C>T	c.(1867-1869)GCC>GTC	p.A623V	ACTN1_uc001xkk.2_Missense_Mutation_p.A219V|ACTN1_uc010ttb.1_Missense_Mutation_p.A558V|ACTN1_uc001xkm.2_Missense_Mutation_p.A623V|ACTN1_uc001xkn.2_Missense_Mutation_p.A623V|ACTN1_uc010ttc.1_Missense_Mutation_p.A208V	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	623	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CTGCTGTCGGGCATGCTCCTC	0.612		NA											5	129					0	0	0	0
TRAF3	7187	broad.mit.edu	37	14	103363706	103363706	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:103363706C>T	uc001ymc.1	+	10	1281	c.928C>T	c.(928-930)CGA>TGA	p.R310*	TRAF3_uc001yme.1_Nonsense_Mutation_p.R285*|TRAF3_uc001ymd.1_Nonsense_Mutation_p.R310*|TRAF3_uc010txy.1_Nonsense_Mutation_p.R227*	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	310	Potential.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GGAAATGCTTCGAAATAATGA	0.378		NA											27	7					0	0	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102895	41102895	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:41102895C>T	uc001zmt.1	+	6	1280	c.766C>T	c.(766-768)CTG>TTG	p.L256L	ZFYVE19_uc001zmu.1_Silent_p.L256L|ZFYVE19_uc001zmv.1_Silent_p.L81L|ZFYVE19_uc001zmw.1_Silent_p.L81L|ZFYVE19_uc001zmx.1_Silent_p.L81L|ZFYVE19_uc010bcc.1_Silent_p.L81L	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	256							zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GACACAGGATCTGCTAACGCA	0.592		NA											2	8					0	0	0	0
ADAL	161823	broad.mit.edu	37	15	43641114	43641114	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:43641114C>T	uc010udo.1	+	10	1136	c.562C>T	c.(562-564)CAA>TAA	p.Q188*	ADAL_uc001zrh.2_Nonsense_Mutation_p.Q215*|ADAL_uc001zri.1_Nonsense_Mutation_p.Q100*	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	215					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GATTCCAAACCAAAAAAAAGA	0.453		NA											36	61					0	0	0	0
ITGAL	3683	broad.mit.edu	37	16	30522385	30522385	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30522385C>G	uc002dyi.3	+	24	2890	c.2714C>G	c.(2713-2715)TCA>TGA	p.S905*	ITGAL_uc002dyj.3_Nonsense_Mutation_p.S821*|ITGAL_uc010vev.1_Nonsense_Mutation_p.S139*	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	905	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AATGAGGACTCAGACCTCCTG	0.567		NA											53	72					0	0	0	0
ITGAL	3683	broad.mit.edu	37	16	30525152	30525152	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30525152C>T	uc002dyi.3	+	25	3023	c.2847C>T	c.(2845-2847)GTC>GTT	p.V949V	ITGAL_uc002dyj.3_Silent_p.V865V|ITGAL_uc010vev.1_Silent_p.V183V	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	949	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TCCACCAAGTCAAGCACATGT	0.507		NA											57	74					0	0	0	0
EFCAB5	374786	broad.mit.edu	37	17	28417554	28417554	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:28417554G>A	uc002het.2	+	20	3991	c.3799G>A	c.(3799-3801)GAT>AAT	p.D1267N	EFCAB5_uc010cse.2_Missense_Mutation_p.D1022N|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1267							calcium ion binding			ovary(1)|skin(1)	2						GGGAGTCCTCGATTTTAACAT	0.428		NA											90	109					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78013852	78013852	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:78013852C>T	uc010dht.2	+	3	362	c.335C>T	c.(334-336)ACG>ATG	p.T112M	CCDC40_uc010wub.1_Missense_Mutation_p.T112M	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	112					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGCAGATACGACTTACCCG	0.483		NA											89	115					0	0	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79966949	79966949	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:79966949G>T	uc002kcx.2	+	8	1067	c.970G>T	c.(970-972)GTG>TTG	p.V324L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.V324L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.V324L|ASPSCR1_uc002kcz.2_Missense_Mutation_p.V218L|ASPSCR1_uc002kda.2_Missense_Mutation_p.V247L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.V247L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	324	Interaction with GLUT4 (By similarity).						protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGAGCCGGTGGTGTGCCACCC	0.721		NA	T	TFE3	alveolar soft part sarcoma								10	3					3.07e-06	3.28e-06	1	0
AES	166	broad.mit.edu	37	19	3054133	3054133	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:3054133C>T	uc002lwy.1	-	6	530	c.357G>A	c.(355-357)CTG>CTA	p.L119L	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Silent_p.L119L|AES_uc002lxa.1_Silent_p.L63L|AES_uc002lxb.1_Silent_p.L186L|AES_uc002lxc.2_Silent_p.L186L	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	119	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGATAGAGTTCAGCTCGGGAG	0.657		NA											14	17					0	0	0	0
ACER1	125981	broad.mit.edu	37	19	6309770	6309770	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:6309770G>A	uc002mel.2	-	4	504	c.426C>T	c.(424-426)AAC>AAT	p.N142N		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	142	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GGGCGTAGGCGTTGACCGTGG	0.607		NA											81	109					0	0	0	0
DMWD	1762	broad.mit.edu	37	19	46289911	46289911	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:46289911C>T	uc002pdj.1	-	3	889	c.843G>A	c.(841-843)GCG>GCA	p.A281A	DMWD_uc002pdk.1_Silent_p.A281A|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	281					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCTCACCCACCGCCCACTTGG	0.677		NA											41	54					0	0	0	0
ZIM2	23619	broad.mit.edu	37	19	57286109	57286109	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:57286109G>T	uc002qnr.2	-	11	1913	c.1531C>A	c.(1531-1533)CAA>AAA	p.Q511K	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.Q307K|ZIM2_uc010ygr.1_Missense_Mutation_p.Q307K|ZIM2_uc002qnq.2_Missense_Mutation_p.Q511K|ZIM2_uc010etp.2_Missense_Mutation_p.Q511K|ZIM2_uc010ygs.1_Missense_Mutation_p.Q511K	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	511	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		TGATAATGTTGAGTGAGGTAT	0.423		NA											64	66					4.84e-39	5.39e-39	1	0
COL3A1	1281	broad.mit.edu	37	2	189854843	189854843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr2:189854843C>T	uc002uqj.1	+	9	829	c.712C>T	c.(712-714)CGA>TGA	p.R238*	COL3A1_uc010frw.1_5'Flank	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383		NA											35	73					0	0	0	0
STK35	140901	broad.mit.edu	37	20	2097996	2097996	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr20:2097996G>A	uc010gak.2	+	3	1577	c.1577G>A	c.(1576-1578)AGA>AAA	p.R526K	STK35_uc010zpu.1_Intron|STK35_uc002wfw.3_Missense_Mutation_p.R393K	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	526	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CTTGAAACCAGAATGGACCAG	0.428		NA											65	10					0	0	0	0
RIPK4	54101	broad.mit.edu	37	21	43161351	43161351	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43161351A>G	uc002yzn.1	-	8	2050	c.2002T>C	c.(2002-2004)TCA>CCA	p.S668P		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	668						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TAGCCGTCTGAGGTCATGGCC	0.687		NA											82	78					0	0	0	0
ABCG1	9619	broad.mit.edu	37	21	43704767	43704767	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43704767G>A	uc002zaq.2	+	7	938	c.832G>A	c.(832-834)GCC>ACC	p.A278T	ABCG1_uc002zan.2_Missense_Mutation_p.A280T|ABCG1_uc002zam.2_Missense_Mutation_p.A256T|ABCG1_uc002zao.2_Missense_Mutation_p.A275T|ABCG1_uc002zap.2_Missense_Mutation_p.A278T|ABCG1_uc002zar.2_Missense_Mutation_p.A289T|ABCG1_uc011aev.1_Missense_Mutation_p.A289T|ABCG1_uc010gpb.1_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	278	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCAGCCCAGCGCCAAACTCTT	0.637		NA											7	209					0	0	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446410	29446410	+	Silent	SNP	T	T	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr22:29446410T>G	uc003aeg.2	+	8	2106	c.1941T>G	c.(1939-1941)GGT>GGG	p.G647G	ZNRF3_uc003aeh.1_Silent_p.G647G	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	747	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						GCCCGGCGGGTGGGGAGCCCC	0.692		NA											9	43					0	0	0	0
AP1B1	162	broad.mit.edu	37	22	29747175	29747175	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr22:29747175G>A	uc003afj.2	-	9	1324	c.1140C>T	c.(1138-1140)TGC>TGT	p.C380C	AP1B1_uc003afi.2_Silent_p.C380C|AP1B1_uc003afk.2_Silent_p.C380C|AP1B1_uc003afl.2_Silent_p.C380C|AP1B1_uc011ako.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	380					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCTTGATGGCGCAGCGGCCAA	0.547		NA											13	482					0	0	0	0
IFRD2	7866	broad.mit.edu	37	3	50326114	50326114	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:50326114C>T	uc011bdp.1	-	10	1373	c.1244G>A	c.(1243-1245)CGC>CAC	p.R415H	IFRD2_uc003czb.2_Missense_Mutation_p.R517H	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	415							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAAGCCGAAGCGCACTATCTC	0.597		NA											18	2					0	0	0	0
MRPL3	11222	broad.mit.edu	37	3	131190031	131190031	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:131190031C>A	uc003eoh.2	-	7	886	c.722G>T	c.(721-723)GGA>GTA	p.G241V	MRPL3_uc011blo.1_Missense_Mutation_p.G136V|MRPL3_uc011blp.1_Missense_Mutation_p.G268V	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	241					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TGCAACAGCTCCAGGTCTCCT	0.423		NA											8	148					0.00307968	0.00318098	1	0
TBC1D14	57533	broad.mit.edu	37	4	7016236	7016236	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:7016236C>T	uc011bwg.1	+	12	1788	c.1709C>T	c.(1708-1710)GCG>GTG	p.A570V	TBC1D14_uc003gjs.3_Missense_Mutation_p.A570V|TBC1D14_uc010idh.2_Missense_Mutation_p.A290V|TBC1D14_uc011bwh.1_Missense_Mutation_p.A217V|TBC1D14_uc003gju.3_Missense_Mutation_p.A61V	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	570	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						AAATTATTTGCGCATTTCAAG	0.358		NA											3	66					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126372965	126372965	+	Silent	SNP	A	A	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:126372965A>G	uc003ifj.3	+	9	10794	c.10794A>G	c.(10792-10794)GGA>GGG	p.G3598G	FAT4_uc011cgp.1_Silent_p.G1896G|FAT4_uc003ifi.1_Silent_p.G1076G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3598	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTCCACAGGAACTGTGCATA	0.428		NA											125	155					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	rs149680468		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								100	120					0	0	0	0
HMGCR	3156	broad.mit.edu	37	5	74651207	74651207	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:74651207C>A	uc003kdp.2	+	14	1896	c.1740C>A	c.(1738-1740)AGC>AGA	p.S580R	HMGCR_uc011cst.1_Missense_Mutation_p.S600R|HMGCR_uc003kdq.2_Missense_Mutation_p.S527R	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	580	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GAGGTGCCAGCAGCCGAGTCC	0.493		NA											94	160					8.45e-40	9.48e-40	1	0
PCDHA3	56145	broad.mit.edu	37	5	140181621	140181621	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:140181621C>G	uc003lhf.2	+	1	839	c.839C>G	c.(838-840)TCT>TGT	p.S280C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.S280C	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	280	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGCGTATTCTTTCAATACG	0.388		NA											69	78					0	0	0	0
PIM1	5292	broad.mit.edu	37	6	37140830	37140830	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:37140830G>A	uc003onk.2	+	5	1096	c.666G>A	c.(664-666)TCG>TCA	p.S222S	PIM1_uc011dtw.1_Missense_Mutation_p.R91Q	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	313	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	ATGGCAGGTCGGCGGCAGTCT	0.522		NA	T	BCL6	NHL								65	97					0	0	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86324547	86324547	+	Missense_Mutation	SNP	T	T	A	rs147197492		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:86324547T>A	uc003pla.2	-	11	2340	c.1799A>T	c.(1798-1800)CAT>CTT	p.H600L	SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Missense_Mutation_p.H565L	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	600					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GTTACCAGAATGATCACCACC	0.478		NA											90	113					0	0	0	0
C6orf174	387104	broad.mit.edu	37	6	127796906	127796906	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:127796906G>A	uc003qbd.2	-	6	3130	c.2265C>T	c.(2263-2265)AGC>AGT	p.S755S	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	755						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TGCCCGCGTCGCTCTCGGCGT	0.692		NA											94	99					0	0	0	0
FNDC1	84624	broad.mit.edu	37	6	159653589	159653589	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:159653589G>A	uc010kjv.2	+	11	2245	c.2045G>A	c.(2044-2046)CGC>CAC	p.R682H	FNDC1_uc010kjw.1_Missense_Mutation_p.R567H	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	682	Ser-rich.					extracellular region		p.R682H(1)		large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCGTTCTCCGCGACAGAAGC	0.716		NA											19	21					0	0	0	0
PLG	5340	broad.mit.edu	37	6	161155067	161155067	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:161155067G>A	uc003qtm.3	+	13	1691	c.1628G>A	c.(1627-1629)TGC>TAC	p.C543Y		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	543	Kringle 5.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGTCCCTGGTGCTACACGACA	0.473		NA											30	31					0	0	0	0
GNB2	2783	broad.mit.edu	37	7	100275401	100275401	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr7:100275401G>A	uc003uwb.2	+	7	730	c.457G>A	c.(457-459)GAT>AAT	p.D153N	GNB2_uc003uwc.2_Missense_Mutation_p.D109N|GNB2_uc010lhd.2_Missense_Mutation_p.D109N|GNB2_uc010lhe.2_Missense_Mutation_p.D109N|GNB2_uc003uwd.2_Missense_Mutation_p.D53N|GNB2_uc010lhf.2_Missense_Mutation_p.D53N|GNB2_uc003uwe.2_Missense_Mutation_p.D153N|GNB2_uc003uwf.2_Missense_Mutation_p.D53N	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	153	WD 3.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				CCGCTTCCTGGATGACAACCA	0.627		NA											46	42					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3245095	3245095	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:3245095C>T	uc011kwk.1	-	18	3096	c.2706G>A	c.(2704-2706)CCG>CCA	p.P902P	CSMD1_uc011kwj.1_Silent_p.P294P|CSMD1_uc003wqe.2_Silent_p.P58P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	902	Extracellular (Potential).|Sushi 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGTGTACCCCGGGTCACAGC	0.607		NA											14	18					0	0	0	0
FZD3	7976	broad.mit.edu	37	8	28384970	28384970	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:28384970C>A	uc003xgx.2	+	5	1171	c.693C>A	c.(691-693)TTC>TTA	p.F231L	FZD3_uc010lvb.2_Missense_Mutation_p.F231L	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	231	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TCACAAGATTCCGTTATCCTG	0.353		NA											86	280					5.72e-32	6.33e-32	1	0
ADAM2	2515	broad.mit.edu	37	8	39624556	39624556	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:39624556A>T	uc003xnj.2	-	14	1393	c.1318T>A	c.(1318-1320)TCA>ACA	p.S440T	ADAM2_uc003xnk.2_Missense_Mutation_p.S421T|ADAM2_uc011lck.1_Missense_Mutation_p.S440T|ADAM2_uc003xnl.2_Missense_Mutation_p.S314T	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	440	Extracellular (Potential).|Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTTCTTTTGACATAAACTGA	0.343		NA											331	117					0	0	0	0
PEX2	5828	broad.mit.edu	37	8	77896111	77896111	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:77896111G>T	uc003yax.2	-	4	762	c.304C>A	c.(304-306)CAA>AAA	p.Q102K	PEX2_uc003yay.2_Missense_Mutation_p.Q102K|PEX2_uc003yaz.2_Missense_Mutation_p.Q102K	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	102					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						CAGATTTTTTGATTTTTACTG	0.373		NA											115	57					4.36e-55	4.96e-55	1	0
RENBP	5973	broad.mit.edu	37	X	153209359	153209359	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chrX:153209359C>T	uc004fjo.1	-	4	447	c.277G>A	c.(277-279)GCA>ACA	p.A93T	RENBP_uc011mzh.1_Missense_Mutation_p.A93T	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	93					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GCTTTTGCTGCGTCCAGAAGC	0.577		NA											6	0					0	0	0	0
SLC16A4	9122	broad.mit.edu	37	1	110906426	110906427	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:110906426_110906427insA	uc001dzo.1	-	9	1607_1608	c.1425_1426insT	c.(1423-1428)TTTGTAfs	p.F475fs	SLC16A4_uc009wfs.1_Frame_Shift_Ins_p.F427fs|SLC16A4_uc001dzp.1_Frame_Shift_Ins_p.F307fs|SLC16A4_uc010ovy.1_Frame_Shift_Ins_p.F413fs|SLC16A4_uc001dzq.1_Frame_Shift_Ins_p.F245fs|SLC16A4_uc010ovz.1_Frame_Shift_Ins_p.L372fs	NM_004696	NP_004687	O15374	MOT5_HUMAN	solute carrier family 16, member 4	475_476	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			ovary(3)	3		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	GCCAATGGTACAAAAAAAAAGG	0.391		NA											10	182	---	---	---	---	NA	NA	NA	NA
KPRP	448834	broad.mit.edu	37	1	152732518	152732520	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152732518_152732520delAAC	uc001fal.1	+	2	512_514	c.454_456delAAC	c.(454-456)AACdel	p.N152del		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	152	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCAGTCCAGAACTATGTACCCT	0.507		NA											96	129	---	---	---	---	NA	NA	NA	NA
IRF2BP2	359948	broad.mit.edu	37	1	234743346	234743348	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:234743346_234743348delTTG	uc001hwg.2	-	2	1330_1332	c.1299_1301delCAA	c.(1297-1302)GACAAT>GAT	p.N434del	IRF2BP2_uc009xfw.2_In_Frame_Del_p.N44del|IRF2BP2_uc001hwf.2_In_Frame_Del_p.N418del	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GCCCCCTGCATTGTCTGCTACTA	0.581		NA											100	182	---	---	---	---	NA	NA	NA	NA
