Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AJAP1	55966	broad.mit.edu	37	1	4832510	4832510	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:4832510C>T	uc001alm.1	+	4	1469	c.1088C>T	c.(1087-1089)GCA>GTA	p.A363V	AJAP1_uc001aln.2_Missense_Mutation_p.A363V	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	363	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TGCGTCAGGGCATCTGTGCCC	0.587		NA											7	52					0	0	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835290	12835290	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:12835290C>T	uc001aui.2	+	1	307	c.280C>T	c.(280-282)CGC>TGC	p.R94C		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	94										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGAAGGTTCGCCCCAGGTG	0.592		NA											34	94					0	0	0	0
PADI3	51702	broad.mit.edu	37	1	17603133	17603133	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:17603133G>T	uc001bai.2	+	12	1467	c.1427G>T	c.(1426-1428)AGC>ATC	p.S476I		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	476					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GAGTTTCTGAGCTTTGTCCCT	0.607		NA											11	124					2.81e-09	3.07e-09	1	0
RAP1GAP	5909	broad.mit.edu	37	1	21928278	21928278	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:21928278C>T	uc001bex.2	-	20	1809	c.1551G>A	c.(1549-1551)CCG>CCA	p.P517P	RAP1GAP_uc001bev.2_Silent_p.P602P|RAP1GAP_uc001bew.2_Silent_p.P581P|RAP1GAP_uc001bey.2_Silent_p.P543P	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	517					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TCTGACCAGCCGGAGGGCTCT	0.667		NA											26	41					0	0	0	0
SFRS4	6429	broad.mit.edu	37	1	29475408	29475408	+	Silent	SNP	C	C	T	rs145832785		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:29475408C>T	uc001bro.2	-	6	1372	c.999G>A	c.(997-999)CGG>CGA	p.R333R	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	333	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		tgctcctgctccggctccgac	0.01		NA											3	41					0	0	0	0
EPS15	2060	broad.mit.edu	37	1	51822456	51822456	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:51822456C>G	uc001csq.1	-	25	2699	c.2607G>C	c.(2605-2607)CAG>CAC	p.Q869H	EPS15_uc009vyz.1_Missense_Mutation_p.Q735H|EPS15_uc001csp.3_Missense_Mutation_p.Q555H	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	869	UIM 1.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						GGGCAAGCCTCTGCTCTTCCT	0.413		NA	T	MLL	ALL								32	87					0	0	0	0
ZYG11B	79699	broad.mit.edu	37	1	53222179	53222179	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:53222179C>T	uc001cuj.2	+	2	275	c.80C>T	c.(79-81)ACT>ATT	p.T27I	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.T18I	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	27							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AATTTCTTGACTACTCACCTT	0.453		NA											17	152					0	0	0	0
ODF2L	57489	broad.mit.edu	37	1	86852648	86852648	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:86852648T>C	uc001dll.1	-	2	403	c.63A>G	c.(61-63)ATA>ATG	p.I21M	ODF2L_uc001dlm.1_Missense_Mutation_p.I21M|ODF2L_uc001dln.2_Missense_Mutation_p.I21M|ODF2L_uc001dlo.2_Translation_Start_Site|ODF2L_uc001dlp.2_Missense_Mutation_p.I21M|ODF2L_uc010osg.1_Missense_Mutation_p.I21M|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	21						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTTTCTCTGATATAGTTTTAA	0.378		NA											22	131					0	0	0	0
PIAS3	10401	broad.mit.edu	37	1	145581474	145581474	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:145581474C>G	uc001eoc.1	+	9	1146	c.1055C>G	c.(1054-1056)GCC>GGC	p.A352G	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.A21G	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	352	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCGATGCTGCCCTTTATCTA	0.517		NA											23	141					0	0	0	0
ARNT	405	broad.mit.edu	37	1	150784502	150784502	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:150784502C>T	uc001evr.1	-	22	2508	c.2365G>A	c.(2365-2367)GAA>AAA	p.E789K	ARNT_uc010pck.1_Missense_Mutation_p.E277K|ARNT_uc001evs.1_Missense_Mutation_p.E774K|ARNT_uc009wmb.1_Missense_Mutation_p.E775K|ARNT_uc009wmc.1_Missense_Mutation_p.E787K|ARNT_uc009wmd.1_Missense_Mutation_p.E773K	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	789					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TAGTTCTATTCTGAAAAGGGG	0.393		NA	T	ETV6	AML								16	84					0	0	0	0
VANGL2	57216	broad.mit.edu	37	1	160394043	160394043	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:160394043A>T	uc001fwb.1	+	8	1574	c.1275A>T	c.(1273-1275)GAA>GAT	p.E425D	VANGL2_uc001fwc.1_Missense_Mutation_p.E425D	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	425	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCACCTTGAATTCTGCATCA	0.567		NA											17	42					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190068182	190068182	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:190068182T>A	uc001gse.1	-	8	1499	c.1267A>T	c.(1267-1269)ACG>TCG	p.T423S	FAM5C_uc010pot.1_Missense_Mutation_p.T321S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	423						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CACGAGTGCGTCTCTTCTGAA	0.542		NA											11	34					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197074167	197074167	+	Missense_Mutation	SNP	C	C	T	rs143092798		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:197074167C>T	uc001gtu.2	-	18	4471	c.4214G>A	c.(4213-4215)CGT>CAT	p.R1405H	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1405	IQ 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TAAATAAGCACGCCAATGCCT	0.313		NA											25	116					0	0	0	0
CD34	947	broad.mit.edu	37	1	208084367	208084367	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:208084367A>G	uc001hgw.1	-	1	317	c.59T>C	c.(58-60)CTT>CCT	p.L20P	CD34_uc001hgx.1_Missense_Mutation_p.L20P|CD34_uc010psj.1_5'UTR	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	20					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						CAGCAAGCAAAGCGCGGTCCA	0.607		NA											4	11					0	0	0	0
TMEM206	55248	broad.mit.edu	37	1	212560368	212560368	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:212560368G>A	uc001hjc.3	-	3	376	c.208C>T	c.(208-210)CTC>TTC	p.L70F	TMEM206_uc010pte.1_Missense_Mutation_p.L131F	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	70	Helical; (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		ATGAAGATGAGTAGGACCGAG	0.542		NA											22	93					0	0	0	0
NLRP3	114548	broad.mit.edu	37	1	247608112	247608112	+	Silent	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:247608112G>C	uc001icr.2	+	10	3138	c.3000G>C	c.(2998-3000)CTG>CTC	p.L1000L	NLRP3_uc001ics.2_Silent_p.L943L|NLRP3_uc001icu.2_Silent_p.L1000L|NLRP3_uc001icw.2_Silent_p.L943L|NLRP3_uc001icv.2_Silent_p.L886L|NLRP3_uc010pyw.1_Silent_p.L978L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	1000					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCCTCCTGCAGAACCTGG	0.562		NA											12	65					0	0	0	0
OR13G1	441933	broad.mit.edu	37	1	247836069	247836069	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:247836069G>C	uc001idi.1	-	1	275	c.275C>G	c.(274-276)GCA>GGA	p.A92G		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATGCAGCCTGCATATGAAAT	0.483		NA											6	56					0	0	0	0
ZNF672	79894	broad.mit.edu	37	1	249142664	249142664	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:249142664C>T	uc001iex.2	+	4	1886	c.1191C>T	c.(1189-1191)TGC>TGT	p.C397C		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	397	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CAGCGGAGTGCGCAGAGTGCG	0.677		NA											3	14					0	0	0	0
ANKRD26	22852	broad.mit.edu	37	10	27324102	27324102	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:27324102C>T	uc001ith.2	-	24	3446	c.3274G>A	c.(3274-3276)GGT>AGT	p.G1092S	ANKRD26_uc001itg.2_Missense_Mutation_p.G779S|ANKRD26_uc009xku.1_Missense_Mutation_p.G1093S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1092	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CGTTCTAAACCCAAAGTCTTT	0.348		NA											17	226					0	0	0	0
SVIL	6840	broad.mit.edu	37	10	29776096	29776096	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:29776096G>A	uc001iut.1	-	24	5234	c.4481C>T	c.(4480-4482)GCG>GTG	p.A1494V	LOC387647_uc001iuq.1_RNA|SVIL_uc010qdw.1_Missense_Mutation_p.A408V|SVIL_uc001iuu.1_Missense_Mutation_p.A1068V|SVIL_uc009xlc.2_Missense_Mutation_p.A286V	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1494	Gelsolin-like 1.|Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACCAACCTTCGCCTTTTCTAT	0.502		NA											6	29					0	0	0	0
MMRN2	79812	broad.mit.edu	37	10	88696664	88696664	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:88696664G>A	uc001kea.2	-	7	2813	c.2686C>T	c.(2686-2688)CCA>TCA	p.P896S	MMRN2_uc010qmn.1_Missense_Mutation_p.P539S	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	896	C1q.					extracellular space				large_intestine(1)	1						GTACAGACTGGAGTCCGATGG	0.597		NA											29	275					0	0	0	0
GPR120	338557	broad.mit.edu	37	10	95326706	95326706	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:95326706C>A	uc010qnt.1	+	1	285	c.229C>A	c.(229-231)CTG>ATG	p.L77M	GPR120_uc010qnu.1_Missense_Mutation_p.L77M	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	77	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				GACTGCCTGCCTGGTACTCAA	0.677		NA											3	43					0.004672	0.00480346	1	0
TRIM21	6737	broad.mit.edu	37	11	4409647	4409647	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:4409647C>T	uc001lyy.1	-	4	731	c.618G>A	c.(616-618)GAG>GAA	p.E206E		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	206	Potential.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		TTCTCAGCTGCTCCCTCTCAT	0.542		NA											86	204					0	0	0	0
SLC43A1	8501	broad.mit.edu	37	11	57261527	57261527	+	Silent	SNP	G	G	A	rs146290858	byFrequency	TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:57261527G>A	uc001nkk.2	-	8	928	c.810C>T	c.(808-810)GAC>GAT	p.D270D	SLC43A1_uc001nkl.2_Silent_p.D270D	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	270					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						CATCCGAACCGTCCTCCAGGC	0.612		NA									OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	58					0	0	0	0
ZFP91	80829	broad.mit.edu	37	11	58379154	58379154	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:58379154A>T	uc001nmx.3	+	6	968	c.800A>T	c.(799-801)GAG>GTG	p.E267V	ZFP91_uc001nmy.3_Missense_Mutation_p.E266V|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	267	Glu-rich.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				gtggaagtagaggtggaggtg	0.189		NA											5	35					0	0	0	0
MRPL49	740	broad.mit.edu	37	11	64893285	64893285	+	Silent	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:64893285C>A	uc001oda.1	+	4	533	c.442C>A	c.(442-444)CGG>AGG	p.R148R	MRPL49_uc001ocz.1_RNA	NM_004927	NP_004918	Q13405	RM49_HUMAN	mitochondrial ribosomal protein L49	148					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0						AGGTACCCTACGGATCAAGGG	0.567		NA											37	140					3.33e-15	3.82e-15	1	0
ODZ4	26011	broad.mit.edu	37	11	78443447	78443447	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:78443447G>A	uc001ozl.3	-	21	3515	c.3052C>T	c.(3052-3054)CGC>TGC	p.R1018C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1018	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GGGTTGGGGCGGGCAAAATTG	0.552		NA											15	35					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92523277	92523277	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:92523277G>C	uc001pdj.3	+	7	4521	c.4504G>C	c.(4504-4506)GAC>CAC	p.D1502H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1502	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TAGCAGCATCGACTCCATCAG	0.507		NA								TCGA Ovarian(4;0.039)			20	182					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92534060	92534060	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:92534060C>T	uc001pdj.3	+	9	7898	c.7881C>T	c.(7879-7881)CCC>CCT	p.P2627P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2627	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCATAGATCCCGATGATGGAG	0.498		NA								TCGA Ovarian(4;0.039)			9	20					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	99690441	99690441	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:99690441G>A	uc001pga.2	+	4	561	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q	CNTN5_uc009ywv.1_Silent_p.Q74Q|CNTN5_uc001pfz.2_Silent_p.Q74Q|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	74					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GGGCAGCTCAGAATTATTATT	0.363		NA											3	28					0	0	0	0
FAM55A	120400	broad.mit.edu	37	11	114392969	114392969	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:114392969G>A	uc001ppa.2	-	6	1356	c.939C>T	c.(937-939)ATC>ATT	p.I313I	FAM55A_uc010rxd.1_Silent_p.I162I	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	455						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TTTGAACACCGATGGCCCTGC	0.433		NA											10	89					0	0	0	0
PKNOX2	63876	broad.mit.edu	37	11	125301235	125301235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:125301235C>T	uc001qbu.2	+	13	1680	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*	PKNOX2_uc010saz.1_Nonsense_Mutation_p.Q427*|PKNOX2_uc010sba.1_Nonsense_Mutation_p.Q427*|PKNOX2_uc010sbb.1_Nonsense_Mutation_p.Q392*|PKNOX2_uc001qbv.2_Nonsense_Mutation_p.Q221*	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	456						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CGACGAGCTGCAGACGACAAA	0.413		NA											4	41					0	0	0	0
SRPR	6734	broad.mit.edu	37	11	126137475	126137475	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:126137475C>G	uc001qdh.2	-	3	385	c.334G>C	c.(334-336)GAT>CAT	p.D112H	SRPR_uc010sbm.1_Missense_Mutation_p.D84H|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	112					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TTTTGGAAATCAAAAGTGCCA	0.418		NA											10	106					0	0	0	0
IQSEC3	440073	broad.mit.edu	37	12	247993	247993	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:247993C>T	uc001qhw.1	+	1	561	c.555C>T	c.(553-555)GTC>GTT	p.V185V	IQSEC3_uc001qhu.1_Silent_p.V185V|IQSEC3_uc001qht.1_Silent_p.V270V|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	488					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCGGGACGTCACGGTGCAGA	0.587		NA											5	19					0	0	0	0
CACNA1C	775	broad.mit.edu	37	12	2659197	2659197	+	Silent	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:2659197G>T	uc009zdu.1	+	10	1792	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L	CACNA1C_uc009zdv.1_Silent_p.L490L|CACNA1C_uc001qkb.2_Silent_p.L493L|CACNA1C_uc001qkc.2_Silent_p.L493L|CACNA1C_uc001qke.2_Silent_p.L493L|CACNA1C_uc001qkf.2_Silent_p.L493L|CACNA1C_uc001qjz.2_Silent_p.L493L|CACNA1C_uc001qkd.2_Silent_p.L493L|CACNA1C_uc001qkg.2_Silent_p.L493L|CACNA1C_uc009zdw.1_Silent_p.L493L|CACNA1C_uc001qkh.2_Silent_p.L493L|CACNA1C_uc001qkl.2_Silent_p.L493L|CACNA1C_uc001qkn.2_Silent_p.L493L|CACNA1C_uc001qko.2_Silent_p.L493L|CACNA1C_uc001qkp.2_Silent_p.L493L|CACNA1C_uc001qkr.2_Silent_p.L493L|CACNA1C_uc001qku.2_Silent_p.L493L|CACNA1C_uc001qkq.2_Silent_p.L493L|CACNA1C_uc001qks.2_Silent_p.L493L|CACNA1C_uc001qkt.2_Silent_p.L493L|CACNA1C_uc001qka.1_Silent_p.L28L|CACNA1C_uc001qki.1_Silent_p.L229L|CACNA1C_uc001qkj.1_Silent_p.L229L|CACNA1C_uc001qkk.1_Silent_p.L229L|CACNA1C_uc001qkm.1_Silent_p.L229L|CACNA1C_uc009zdy.1_Silent_p.L118L|CACNA1C_uc001qkv.1_Silent_p.L63L	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	493	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGGCCAGGCTGGCGTGAGTAG	0.592		NA											9	10					4.69e-08	5.07e-08	1	0
SLC2A3	6515	broad.mit.edu	37	12	8075605	8075605	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:8075605T>A	uc001qtr.2	-	9	1346	c.1084A>T	c.(1084-1086)ATG>TTG	p.M362L		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	362	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		ACAAAGCTCATCCCATTATAG	0.423		NA											8	40					0	0	0	0
SENP1	29843	broad.mit.edu	37	12	48457609	48457609	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:48457609T>A	uc001rqx.2	-	13	1737	c.1291A>T	c.(1291-1293)ATA>TTA	p.I431L	SENP1_uc001rqw.2_Missense_Mutation_p.I431L|SENP1_uc001rqy.2_Missense_Mutation_p.I232L|SENP1_uc001rqz.2_Missense_Mutation_p.I232L|SENP1_uc009zkx.2_Missense_Mutation_p.I431L	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	431					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ACATTCTTTATTTCTTTCTCC	0.383		NA											10	22					0	0	0	0
STAC3	246329	broad.mit.edu	37	12	57640593	57640593	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:57640593C>G	uc001snp.2	-	6	792	c.597G>C	c.(595-597)AAG>AAC	p.K199N	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Missense_Mutation_p.K160N|STAC3_uc010srm.1_Missense_Mutation_p.K13N	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	199					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TCACATTTTTCTTATCTGCCT	0.498		NA											23	325					0	0	0	0
HELB	92797	broad.mit.edu	37	12	66696407	66696408	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:66696407_66696408GC>TT	uc001sti.2	+	1	52_53	c.24_25GC>TT	c.(22-27)CTGCGC>CTTTGC	p.R9C	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	9					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GTCCGTACCTGCGCCAACTTCA	0.55		NA											17	91					0	0	0	0
NBEA	26960	broad.mit.edu	37	13	36129126	36129126	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:36129126G>A	uc001uvb.2	+	44	7015	c.6809G>A	c.(6808-6810)AGG>AAG	p.R2270K	NBEA_uc010abi.2_Missense_Mutation_p.R926K|NBEA_uc010tee.1_Missense_Mutation_p.R63K|NBEA_uc010tef.1_Missense_Mutation_p.R63K|NBEA_uc010teg.1_Missense_Mutation_p.R63K	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2270						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATTGCTAGGAGGATATCATTG	0.318		NA											6	45					0	0	0	0
CCDC70	83446	broad.mit.edu	37	13	52439668	52439668	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:52439668C>T	uc001vfu.3	+	2	450	c.154C>T	c.(154-156)CGC>TGC	p.R52C	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	52						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AAAGGCTTTTCGCGAAGAGAT	0.517		NA											26	173					0	0	0	0
NEK5	341676	broad.mit.edu	37	13	52660423	52660423	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:52660423C>G	uc001vge.2	-	16	1609	c.1469G>C	c.(1468-1470)AGA>ACA	p.R490T		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	490							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCTGGTTCTCTCCCCATCTT	0.363		NA											17	215					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58207106	58207106	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:58207106G>A	uc001vhq.1	+	1	1318	c.426G>A	c.(424-426)TCG>TCA	p.S142S	PCDH17_uc010aec.1_Silent_p.S142S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	142	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGGACATCTCGGAGAACGCTG	0.617		NA											21	24					0	0	0	0
EFS	10278	broad.mit.edu	37	14	23826643	23826643	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:23826643C>T	uc001wjo.2	-	6	2086	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	EFS_uc001wjp.2_Missense_Mutation_p.R400Q|EFS_uc010tnm.1_Missense_Mutation_p.R324Q	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	493					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGCTGCCAGCCGGCCCAGGGT	0.657		NA											19	42					0	0	0	0
AKAP6	9472	broad.mit.edu	37	14	33147632	33147632	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:33147632A>T	uc001wrq.2	+	8	3016	c.2846A>T	c.(2845-2847)GAT>GTT	p.D949V	AKAP6_uc010aml.2_Missense_Mutation_p.D946V	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	949					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGTTTGCTGATATGTCAAAA	0.413		NA											36	105					0	0	0	0
FRMD6	122786	broad.mit.edu	37	14	52194513	52194513	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:52194513C>T	uc001wzd.2	+	14	1920	c.1635C>T	c.(1633-1635)CTC>CTT	p.L545L	FRMD6_uc001wzb.2_Silent_p.L537L|FRMD6_uc001wzc.2_Silent_p.L537L|FRMD6_uc001wze.2_Silent_p.L468L|FRMD6_uc001wzf.2_Silent_p.L238L|FRMD6_uc001wzg.2_Silent_p.L187L	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	545						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GCTTGAGCCTCGATGACATCA	0.453		NA											10	148					0	0	0	0
PIF1	80119	broad.mit.edu	37	15	65114583	65114583	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:65114583C>T	uc002ant.2	-	4	765	c.699G>A	c.(697-699)GGG>GGA	p.G233G	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Silent_p.G233G|PIF1_uc002anu.2_Missense_Mutation_p.G262E	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	233	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.|ATP (Potential).				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						GATATGACTTCCCTGTTCCTG	0.617		NA											38	72					0	0	0	0
UACA	55075	broad.mit.edu	37	15	70960340	70960340	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:70960340G>C	uc002asr.2	-	16	2787	c.2683C>G	c.(2683-2685)CAG>GAG	p.Q895E	UACA_uc010uke.1_Missense_Mutation_p.Q786E|UACA_uc002asq.2_Missense_Mutation_p.Q882E|UACA_uc010bin.1_Missense_Mutation_p.Q870E	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	895	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						ACAAATTCCTGATTTATATCT	0.308		NA											11	33					0	0	0	0
SEMA7A	8482	broad.mit.edu	37	15	74707066	74707066	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:74707066C>T	uc002axv.2	-	10	1156	c.1116G>A	c.(1114-1116)CCG>CCA	p.P372P	SEMA7A_uc010ulk.1_Silent_p.P207P|SEMA7A_uc010ull.1_Silent_p.P358P	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	372	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						CTGTGGGTATCGGCTGCTGGT	0.652		NA											42	117					0	0	0	0
CTSH	1512	broad.mit.edu	37	15	79231500	79231500	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:79231500G>A	uc002ben.2	-	3	166	c.69C>T	c.(67-69)TTC>TTT	p.F23F	CTSH_uc010unf.1_RNA|CTSH_uc010bll.1_Intron|CTSH_uc010ung.1_Silent_p.F35F	NM_148979	NP_683880	P09668	CATH_HUMAN	cathepsin H isoform b precursor	35					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(2)|large_intestine(1)	3						TCCATGACTTGAAGTGAAACT	0.368		NA											9	60					0	0	0	0
KIAA1199	57214	broad.mit.edu	37	15	81224351	81224351	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:81224351G>A	uc002bfw.1	+	21	3024	c.2764G>A	c.(2764-2766)GTG>ATG	p.V922M	KIAA1199_uc010unn.1_Missense_Mutation_p.V922M	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	922										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CCATAACAACGTGACCGGCAT	0.602		NA											52	217					0	0	0	0
PEX11A	8800	broad.mit.edu	37	15	90229778	90229778	+	Splice_Site	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:90229778C>G	uc002boi.2	-	2	152	c.57_splice	c.e2-1	p.R19_splice	PEX11A_uc010upy.1_Intron	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha						cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGAGTGGCTCTGAAATGGAA	0.378		NA											15	169					0	0	0	0
TUFM	7284	broad.mit.edu	37	16	28856350	28856350	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:28856350G>A	uc002drh.2	-	4	580	c.441C>T	c.(439-441)CTC>CTT	p.L147L	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	144						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						TGCAGCCGTCGAGGGGTGCAG	0.542		NA											18	85					0	0	0	0
NLRC5	84166	broad.mit.edu	37	16	57088721	57088721	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:57088721C>T	uc002ekk.1	+	25	3790	c.3565C>T	c.(3565-3567)CTG>TTG	p.L1189L	NLRC5_uc002ekn.2_Silent_p.L908L|NLRC5_uc002ekl.2_Silent_p.L994L|NLRC5_uc002ekm.2_Silent_p.L964L|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Silent_p.L105L|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Silent_p.L105L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1189					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CACCTTAAGCCTGTGTCCACG	0.577		NA											99	297					0	0	0	0
ZNF319	57567	broad.mit.edu	37	16	58030907	58030907	+	Silent	SNP	G	G	A	rs150126886		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:58030907G>A	uc002emx.1	-	2	1886	c.1263C>T	c.(1261-1263)CCC>CCT	p.P421P		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	421	C2H2-type 11; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGGCCGCGCCGGGCAGGCACT	0.662		NA											7	55					0	0	0	0
DDX19A	55308	broad.mit.edu	37	16	70398481	70398481	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:70398481C>A	uc002eyv.2	+	6	493	c.422C>A	c.(421-423)ACT>AAT	p.T141N	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Missense_Mutation_p.T142N|DDX19A_uc010cfq.1_Intron|DDX19A_uc010cfr.2_Translation_Start_Site|DDX19A_uc010cfs.2_Translation_Start_Site|DDX19A_uc010vlz.1_Missense_Mutation_p.T110N|DDX19A_uc010vma.1_Missense_Mutation_p.T51N	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	141	ATP (By similarity).|Helicase ATP-binding.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				CAGTCTGGCACTGGTAAAACA	0.498		NA											3	81					0.00909568	0.00929129	1	0
PHLPP2	23035	broad.mit.edu	37	16	71710374	71710374	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:71710374G>A	uc002fax.2	-	8	1453	c.1447C>T	c.(1447-1449)CGG>TGG	p.R483W	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.R483W	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	483	LRR 11.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TAGAGGGTCCGAAGGGAAAAG	0.502		NA											7	51					0	0	0	0
SMG6	23293	broad.mit.edu	37	17	2203496	2203496	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:2203496C>T	uc002fub.1	-	2	606	c.551G>A	c.(550-552)GGA>GAA	p.G184E	SMG6_uc002fud.1_Missense_Mutation_p.G153E	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	184	Interaction with telomeric DNA.|Potential.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						CGCAACATTTCCCCTACACTC	0.502		NA											131	582					0	0	0	0
OR1G1	8390	broad.mit.edu	37	17	3030782	3030782	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:3030782C>T	uc002fvc.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTGCTCCTCCAGCTGCTCA	0.493		NA											12	112					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578394	7578394	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	53					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578461	7578461	+	Missense_Mutation	SNP	C	C	A	rs121912654		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7578461C>A	uc002gim.2	-	5	663	c.469G>T	c.(469-471)GTC>TTC	p.V157F	TP53_uc002gig.1_Missense_Mutation_p.V157F|TP53_uc002gih.2_Missense_Mutation_p.V157F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25F|TP53_uc010cng.1_Missense_Mutation_p.V25F|TP53_uc002gii.1_Missense_Mutation_p.V25F|TP53_uc010cnh.1_Missense_Mutation_p.V157F|TP53_uc010cni.1_Missense_Mutation_p.V157F|TP53_uc002gij.2_Missense_Mutation_p.V157F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64F|TP53_uc002gio.2_Missense_Mutation_p.V25F|TP53_uc010vug.1_Missense_Mutation_p.V118F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	63					2.71e-06	2.89e-06	1	0
WRAP53	55135	broad.mit.edu	37	17	7604804	7604804	+	Silent	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7604804G>T	uc010vuh.1	+	6	914	c.759G>T	c.(757-759)CCG>CCT	p.P253P	WRAP53_uc010vui.1_Silent_p.P253P|WRAP53_uc002gip.2_Silent_p.P253P|WRAP53_uc002gir.2_Silent_p.P253P|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Silent_p.P220P|WRAP53_uc010vuj.1_Silent_p.P34P	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	253	WD 2.				positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						GGGAGAACCCGATTCATATCT	0.537		NA											40	119					3.43e-17	3.94e-17	1	0
PER1	5187	broad.mit.edu	37	17	8049769	8049769	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:8049769G>A	uc002gkd.2	-	16	2197	c.1959C>T	c.(1957-1959)TCC>TCT	p.S653S	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.S637S	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	653	Poly-Ser.|CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						AGGAGGAGGAGGAGGCACATT	0.587		NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					41	126					0	0	0	0
C17orf76	388341	broad.mit.edu	37	17	16347302	16347302	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:16347302G>T	uc010cph.1	-	4	811	c.635C>A	c.(634-636)ACA>AAA	p.T212K	C17orf76_uc002gqh.2_Missense_Mutation_p.H173Q|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|C17orf76_uc002gqg.1_3'UTR	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	212	LRR 1.										0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CGTGAGGCCTGTGAAGCCCAG	0.657		NA											18	55					5.01e-05	5.3e-05	1	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305733	39305733	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:39305733C>A	uc002hwb.2	-	1	322	c.287G>T	c.(286-288)TGC>TTC	p.C96F		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	101	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|17.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gctggggcagcagcaggtggt	0.124		NA											14	39					2.35e-11	2.64e-11	1	0
SLC4A1	6521	broad.mit.edu	37	17	42335957	42335957	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:42335957C>G	uc002igf.3	-	10	1060	c.911G>C	c.(910-912)CGA>CCA	p.R304P	SLC4A1_uc002igg.3_Missense_Mutation_p.R304P	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	304	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CAGCTCCCCTCGGCTCTGAGC	0.647		NA											5	27					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78321813	78321813	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:78321813C>T	uc002jyh.1	+	4	4120	c.3897C>T	c.(3895-3897)TGC>TGT	p.C1299C		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CGGACGCCTGCGCGTCTGTGG	0.562		NA											6	30					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14513734	14513734	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:14513734C>T	uc010dln.2	-	10	1914	c.1460G>A	c.(1459-1461)GGA>GAA	p.G487E	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	487										skin(3)	3						TTGTGATATTCCAGTGTTCTG	0.323		NA											5	109					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18534783	18534783	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:18534783G>T	uc002kte.2	-	31	4755	c.3814C>A	c.(3814-3816)CAC>AAC	p.H1272N		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1272	PH.|Auto-inhibitory.|Phorbol-ester/DAG-type.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TTATCTAAGTGATCTCTGTGG	0.393		NA											11	195					1.15e-07	1.24e-07	1	0
CCDC102B	79839	broad.mit.edu	37	18	66541993	66541993	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:66541993G>A	uc002lkk.2	+	7	1247	c.1024G>A	c.(1024-1026)GAC>AAC	p.D342N	CCDC102B_uc002lki.2_Missense_Mutation_p.D342N|CCDC102B_uc002lkj.1_Missense_Mutation_p.D342N	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	342										ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAACAGCAAAGACAGAGTGAT	0.333		NA											9	87					0	0	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564499	66564499	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:66564499G>T	uc002lkk.2	+	8	1320	c.1097G>T	c.(1096-1098)AGG>ATG	p.R366M	CCDC102B_uc002lki.2_Missense_Mutation_p.R366M|CCDC102B_uc002lkj.1_Missense_Mutation_p.R366M	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	366	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TGGGACAAGAGGGAAATACTT	0.403		NA											24	105					1.66e-10	1.84e-10	1	0
TSHZ1	10194	broad.mit.edu	37	18	72999255	72999255	+	Silent	SNP	G	G	A	rs145239521		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:72999255G>A	uc002lly.2	+	2	2321	c.1758G>A	c.(1756-1758)CCG>CCA	p.P586P		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	631						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CGCCCCCACCGCACAAGAGCA	0.632		NA											3	60					0	0	0	0
ISYNA1	51477	broad.mit.edu	37	19	18546863	18546863	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:18546863G>T	uc002njd.1	-	7	1004	c.954C>A	c.(952-954)TTC>TTA	p.F318L	ISYNA1_uc002nja.1_Missense_Mutation_p.F190L|ISYNA1_uc002njb.1_Missense_Mutation_p.F236L|ISYNA1_uc002njc.1_Missense_Mutation_p.F168L|ISYNA1_uc010xqh.1_Missense_Mutation_p.F116L|ISYNA1_uc002nje.1_Missense_Mutation_p.F264L|ISYNA1_uc002njf.1_Missense_Mutation_p.F168L	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	318					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						AGCCAATGAGGAAGTCCACAA	0.652		NA											12	35					7.04e-09	7.63e-09	1	0
ZNF708	7562	broad.mit.edu	37	19	21476477	21476477	+	Missense_Mutation	SNP	T	T	C	rs149009596		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:21476477T>C	uc002npq.1	-	4	1489	c.1291A>G	c.(1291-1293)ATA>GTA	p.I431V	ZNF708_uc002npr.1_Missense_Mutation_p.I367V|ZNF708_uc010ecs.1_Missense_Mutation_p.I367V	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	431	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ATTGAGAATATACTAAAGGCT	0.328		NA											20	70					0	0	0	0
ZBTB32	27033	broad.mit.edu	37	19	36207617	36207617	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:36207617C>T	uc002oay.2	+	6	1637	c.1427C>T	c.(1426-1428)TCG>TTG	p.S476L	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	476					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCGGCCCTCGACCTCTCCC	0.632		NA									OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	158					0	0	0	0
ZFP82	284406	broad.mit.edu	37	19	36883703	36883703	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:36883703C>T	uc002ody.1	-	5	1774	c.1539G>A	c.(1537-1539)AAG>AAA	p.K513K		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	513	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GCCTAAAGGCCTTCTTACATT	0.338		NA											19	79					0	0	0	0
HKR1	284459	broad.mit.edu	37	19	37853704	37853704	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:37853704G>A	uc002ogb.2	+	6	1276	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q	HKR1_uc002ofx.2_Missense_Mutation_p.R52Q|HKR1_uc002ofy.2_Missense_Mutation_p.R52Q|HKR1_uc002oga.2_Missense_Mutation_p.R318Q|HKR1_uc010xto.1_Missense_Mutation_p.R318Q|HKR1_uc002ogc.2_Missense_Mutation_p.R317Q|HKR1_uc010xtp.1_Missense_Mutation_p.R275Q|HKR1_uc002ogd.2_Missense_Mutation_p.R275Q	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	336	C2H2-type 2.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATTGTGGACGAGGCTTTACT	0.507		NA											14	118					0	0	0	0
HNRNPL	3191	broad.mit.edu	37	19	39340525	39340525	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:39340525G>C	uc010xul.1	-	1	93	c.82C>G	c.(82-84)CGG>GGG	p.R28G	HNRNPL_uc010xum.1_Intron	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	28					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GCTCCCGACCGCCTCCGCTGC	0.512		NA											3	1					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40357679	40357679	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:40357679C>G	uc002omp.3	-	34	15642	c.15634G>C	c.(15634-15636)GGC>CGC	p.G5212R		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5212	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGTGGGCAGCCAGCTGCCTGG	0.622		NA											19	72					0	0	0	0
GIPR	2696	broad.mit.edu	37	19	46185005	46185005	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:46185005C>G	uc002pcu.1	+	14	1312	c.1213C>G	c.(1213-1215)CGT>GGT	p.R405G	GIPR_uc002pct.1_3'UTR|GIPR_uc010xxp.1_Missense_Mutation_p.R369G|GIPR_uc010xxq.1_RNA	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	405	Cytoplasmic (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		GGAGATCCGCCGTGGCTGGCA	0.776		NA											7	7					0	0	0	0
DMPK	1760	broad.mit.edu	37	19	46281829	46281829	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:46281829G>A	uc002pdd.1	-	4	1077	c.533C>T	c.(532-534)CCG>CTG	p.P178L	DMPK_uc010xxs.1_Missense_Mutation_p.P79L|DMPK_uc002pde.1_Missense_Mutation_p.P178L|DMPK_uc002pdf.1_Missense_Mutation_p.P168L|DMPK_uc002pdg.1_Missense_Mutation_p.P168L|DMPK_uc002pdh.1_Missense_Mutation_p.P168L|DMPK_uc002pdi.1_Missense_Mutation_p.P194L|DMPK_uc010xxt.1_Missense_Mutation_p.P168L|DMPK_uc010xxu.1_3'UTR	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	178	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CATCTCGGCCGGAATCCGCTC	0.612		NA											3	66					0	0	0	0
ZNF264	9422	broad.mit.edu	37	19	57724189	57724189	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:57724189C>A	uc002qob.2	+	4	2137	c.1724C>A	c.(1723-1725)CCT>CAT	p.P575H		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GTGGGAAGACCTTTTACAAGT	0.443		NA											32	129					1.63e-12	1.84e-12	1	0
ZNF547	284306	broad.mit.edu	37	19	57889289	57889289	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:57889289G>C	uc002qol.2	+	4	1138	c.945G>C	c.(943-945)CAG>CAC	p.Q315H	ZNF547_uc002qpm.3_Missense_Mutation_p.Q241H|ZNF547_uc010ygx.1_Missense_Mutation_p.Q315H	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	315	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTAGACATCAGAGAGTTCACA	0.413		NA											17	142					0	0	0	0
ZNF544	27300	broad.mit.edu	37	19	58772562	58772562	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:58772562A>G	uc010euo.2	+	7	1064	c.590A>G	c.(589-591)AAT>AGT	p.N197S	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.N169S|ZNF544_uc010yhy.1_Missense_Mutation_p.N169S|ZNF544_uc002qrt.3_Missense_Mutation_p.N55S|ZNF544_uc002qru.3_Missense_Mutation_p.N55S|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TTGAAACAAAATTCAGCTTTC	0.383		NA											17	88					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25468890	25468890	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:25468890C>G	uc002rgc.2	-	12	1730	c.1473G>C	c.(1471-1473)GAG>GAC	p.E491D	DNMT3A_uc002rgd.2_Missense_Mutation_p.E491D|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.E302D	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	491	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAACTTACCCTCAATGTTCC	0.607		NA	Mis|F|N|S		AML								11	79					0	0	0	0
FAM179A	165186	broad.mit.edu	37	2	29249763	29249763	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:29249763C>G	uc010ezl.2	+	14	2249	c.1898C>G	c.(1897-1899)TCA>TGA	p.S633*	FAM179A_uc010ymm.1_Nonsense_Mutation_p.S578*|FAM179A_uc002rmr.3_Nonsense_Mutation_p.S160*	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	633							binding			ovary(3)|skin(1)	4						GAGCACCTCTCAGCTGTGCTG	0.597		NA											4	10					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32664671	32664671	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:32664671G>T	uc010ezu.2	+	16	3861	c.3727G>T	c.(3727-3729)GTA>TTA	p.V1243L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1243					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TATGCGTCCTGTAGTAAGGCT	0.413		NA											3	65					0.00909568	0.00929129	1	0
CYP26B1	56603	broad.mit.edu	37	2	72361996	72361996	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:72361996C>T	uc002sih.1	-	4	755	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	CYP26B1_uc010yra.1_Missense_Mutation_p.R235Q|CYP26B1_uc010yrb.1_Missense_Mutation_p.R177Q	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	252					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CAGCTTCTCCCGGATGGCCTT	0.602		NA											18	70					0	0	0	0
GPAT2	150763	broad.mit.edu	37	2	96690176	96690176	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:96690176G>A	uc002svf.2	-	15	1891	c.1668C>T	c.(1666-1668)GGC>GGT	p.G556G	GPAT2_uc002svd.2_Silent_p.G375G|GPAT2_uc002sve.2_Silent_p.G358G|GPAT2_uc002svg.2_Silent_p.G435G|GPAT2_uc010yuh.1_Silent_p.G485G|GPAT2_uc002svh.2_Silent_p.G556G	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	556					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						AAGACTCACCGCCCACAGCCT	0.632		NA											9	61					0	0	0	0
NCK2	8440	broad.mit.edu	37	2	106497993	106497993	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:106497993G>A	uc002tdg.2	+	4	878	c.436G>A	c.(436-438)GAC>AAC	p.D146N	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.D146N	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	146	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GAAGTGCAGCGACGGTTGGTG	0.637		NA											23	40					0	0	0	0
GCC2	9648	broad.mit.edu	37	2	109085540	109085540	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:109085540G>C	uc002tec.2	+	5	475	c.321G>C	c.(319-321)GAG>GAC	p.E107D	GCC2_uc002ted.2_Missense_Mutation_p.E6D	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	107					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGAGGTTGAGGTAAGTCAAT	0.303		NA											19	97					0	0	0	0
IL1F9	56300	broad.mit.edu	37	2	113737637	113737637	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:113737637G>C	uc002tio.1	+	4	281	c.212G>C	c.(211-213)AGA>ACA	p.R71T	IL1F9_uc010fkr.1_Missense_Mutation_p.R36T	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	71					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						GAGCAAGGCAGAGGGGATCCC	0.423		NA											13	93					0	0	0	0
BIN1	274	broad.mit.edu	37	2	127821184	127821184	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:127821184G>A	uc002tns.1	-	9	1082	c.737C>T	c.(736-738)GCG>GTG	p.A246V	BIN1_uc010yzf.1_Missense_Mutation_p.A191V|BIN1_uc010yzg.1_Missense_Mutation_p.A246V|BIN1_uc002tnu.1_Missense_Mutation_p.A215V|BIN1_uc002toa.1_Missense_Mutation_p.A215V|BIN1_uc002tnt.1_Missense_Mutation_p.A215V|BIN1_uc002tnv.1_Missense_Mutation_p.A246V|BIN1_uc002tnw.1_Missense_Mutation_p.A215V|BIN1_uc002tnx.1_Missense_Mutation_p.A215V|BIN1_uc002tny.1_Missense_Mutation_p.A246V|BIN1_uc002tnz.1_Missense_Mutation_p.A215V|BIN1_uc002tob.1_Missense_Mutation_p.A215V|BIN1_uc002toc.1_Missense_Mutation_p.A215V	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	246	BAR.|Potential.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTCCAGGCCCGCGATGCTCTG	0.602		NA											9	28					0	0	0	0
AMMECR1L	83607	broad.mit.edu	37	2	128631411	128631411	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:128631411T>C	uc002tpl.2	-	3	649	c.398A>G	c.(397-399)AAT>AGT	p.N133S	AMMECR1L_uc002tpm.2_Missense_Mutation_p.N133S	NM_031445	NP_113633	Q6DCA0	AMERL_HUMAN	AMME chromosomal region gene 1-like	133	AMMECR1.									central_nervous_system(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		CTAGGGGTCATTGGTGAATCT	0.507		NA											21	264					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141533692	141533692	+	Silent	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:141533692T>C	uc002tvj.1	-	33	6447	c.5475A>G	c.(5473-5475)AAA>AAG	p.K1825K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1825	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATCATAGACTTTCATATGAA	0.418		NA								TSP Lung(27;0.18)			42	108					0	0	0	0
SP5	389058	broad.mit.edu	37	2	171573747	171573747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:171573747C>T	uc002uge.2	+	2	1196	c.1030C>T	c.(1030-1032)CAG>TAG	p.Q344*		NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	344	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGACGAGCTGCAGCGGCACCT	0.667		NA											6	22					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179411014	179411014	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179411014C>G	uc010zfg.1	-	291	87564	c.87340G>C	c.(87340-87342)GAC>CAC	p.D29114H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22809H|TTN_uc010zfi.1_Missense_Mutation_p.D22742H|TTN_uc010zfj.1_Missense_Mutation_p.D22617H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30041							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCACTGTCACTTCTGTCA	0.448		NA											62	234					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179442069	179442069	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179442069G>A	uc010zfg.1	-	273	61513	c.61289C>T	c.(61288-61290)TCA>TTA	p.S20430L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S14125L|TTN_uc010zfi.1_Missense_Mutation_p.S14058L|TTN_uc010zfj.1_Missense_Mutation_p.S13933L|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21357							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTGGGGTTGAAGTTATCTG	0.423		NA											5	76					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212589879	212589879	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:212589879G>A	uc002veg.1	-	6	761	c.663C>T	c.(661-663)TGC>TGT	p.C221C	ERBB4_uc002veh.1_Silent_p.C221C|ERBB4_uc010zji.1_Silent_p.C221C|ERBB4_uc010zjj.1_Silent_p.C221C|ERBB4_uc010fut.1_Silent_p.C221C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	221	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AAGGTCCGTAGCATCTGCCGT	0.498		NA								TSP Lung(8;0.080)			30	114					0	0	0	0
FAM124B	79843	broad.mit.edu	37	2	225266461	225266461	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:225266461C>T	uc002vnx.2	-	1	251	c.25G>A	c.(25-27)GCC>ACC	p.A9T	FAM124B_uc002vnw.2_Missense_Mutation_p.A9T	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	9							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		ACAGTCATGGCCAGAGGCCCC	0.542		NA											17	63					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228153932	228153933	+	Missense_Mutation	DNP	TC	TC	AG			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:228153932_228153933TC>AG	uc002vom.1	+	35	3110_3111	c.2948_2949TC>AG	c.(2947-2949)CTC>CAG	p.L983Q	COL4A3_uc002von.1_Missense_Mutation_p.L983Q|COL4A3_uc002voo.1_Missense_Mutation_p.L983Q|COL4A3_uc002vop.1_Missense_Mutation_p.L983Q|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	983	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTAAAGGGCCTCAAAGGACTAC	0.416		NA											3	36					0	0	0	0
SEPT2	4735	broad.mit.edu	37	2	242277151	242277151	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:242277151C>T	uc002wbc.2	+	8	961	c.540C>T	c.(538-540)GTC>GTT	p.V180V	SEPT2_uc002wbd.2_Silent_p.V180V|SEPT2_uc002wbf.2_Silent_p.V180V|SEPT2_uc002wbg.2_Silent_p.V180V|SEPT2_uc002wbh.2_Silent_p.V190V|SEPT2_uc010zop.1_Silent_p.V215V	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	180					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		TTGTGCCTGTCATTGCAAAAG	0.463		NA											25	120					0	0	0	0
RBCK1	10616	broad.mit.edu	37	20	398254	398254	+	Silent	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr20:398254C>G	uc002wdp.3	+	3	945	c.252C>G	c.(250-252)CTC>CTG	p.L84L	RBCK1_uc010zpl.1_Silent_p.L84L|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Silent_p.L42L|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_5'UTR	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	84	Interaction with IRF3.|Ubiquitin-like.|Interaction with RNF31.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				TGGCGTCTCTCAAGGACATGG	0.443		NA											4	73					0	0	0	0
RNF160	26046	broad.mit.edu	37	21	30339459	30339459	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:30339459G>T	uc002ymr.2	-	10	1505	c.1492C>A	c.(1492-1494)CAA>AAA	p.Q498K	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	452							ligase activity|zinc ion binding				0						TGCCCATGTTGCAATCCTGGG	0.323		NA											23	93					2.32e-17	2.67e-17	1	0
GCFC1	94104	broad.mit.edu	37	21	34123488	34123488	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:34123488C>A	uc002yqn.2	-	9	1739	c.1549G>T	c.(1549-1551)GAT>TAT	p.D517Y	GCFC1_uc002yql.2_Missense_Mutation_p.D26Y|GCFC1_uc002yqm.2_Missense_Mutation_p.D11Y|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D517Y	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	517						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AGTGCCCGATCGCGTCCAAAG	0.463		NA											35	113					3.76e-14	4.27e-14	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20127356	20127356	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:20127356C>T	uc002zrq.2	+	4	604	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ZDHHC8_uc002zrr.1_Silent_p.F166F|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	166	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TCGTGGCCTTCGGCCTGGTCT	0.602		NA											10	67					0	0	0	0
SMARCB1	6598	broad.mit.edu	37	22	24135759	24135759	+	Silent	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:24135759G>T	uc002zyb.2	+	3	453	c.246G>T	c.(244-246)ACG>ACT	p.T82T	SMARCB1_uc002zyg.2_Silent_p.T82T|SMARCB1_uc011ajb.1_Silent_p.T73T|SMARCB1_uc002zya.2_Silent_p.T82T|SMARCB1_uc002zyc.2_Silent_p.T73T|SMARCB1_uc002zyd.2_Silent_p.T73T|SMARCB1_uc002zye.1_Silent_p.T45T|SMARCB1_uc002zyf.1_RNA|SMARCB1_uc010gue.1_Intron	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	82					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				ACGGATACACGACTCTAGCCA	0.532		NA	D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				53	179					1.46e-29	1.69e-29	1	0
CRYBA4	1413	broad.mit.edu	37	22	27024279	27024279	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:27024279T>A	uc003acz.3	+	5	363	c.328T>A	c.(328-330)TTC>ATC	p.F110I		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	110	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GCTGACAATCTTCGAGCAAGA	0.562		NA											4	85					0	0	0	0
ELFN2	114794	broad.mit.edu	37	22	37770534	37770534	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:37770534C>T	uc003asq.3	-	3	1827	c.1041G>A	c.(1039-1041)ACG>ACA	p.T347T		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	347	Fibronectin type-III.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GTTTGTCCAGCGTCACGATCT	0.572		NA											53	141					0	0	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41623203	41623203	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:41623203C>T	uc003azo.2	+	14	1752	c.1698C>T	c.(1696-1698)CTC>CTT	p.L566L	L3MBTL2_uc010gyi.1_Silent_p.L475L|L3MBTL2_uc003azn.2_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	566	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						ATCGGCTCCTCAGCATCCACT	0.627		NA											3	28					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39227663	39227663	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:39227663C>A	uc003cjk.1	-	2	3495	c.3274G>T	c.(3274-3276)GGT>TGT	p.G1092C	XIRP1_uc003cji.2_Missense_Mutation_p.G1092C|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1092							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TTCCGAAGACCGTCCTGGATG	0.602		NA											15	86					1.03e-11	1.16e-11	1	0
OR5AC2	81050	broad.mit.edu	37	3	97806283	97806283	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:97806283C>T	uc011bgs.1	+	1	267	c.267C>T	c.(265-267)GAC>GAT	p.D89D		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATTTCTTAGACAAGACTGCAA	0.428		NA											58	354					0	0	0	0
ITGB5	3693	broad.mit.edu	37	3	124515329	124515329	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:124515329G>A	uc003eho.2	-	10	1896	c.1599C>T	c.(1597-1599)TGC>TGT	p.C533C	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	533	Extracellular (Potential).|II.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		CGAAGCAGGAGCACTGGTTGC	0.597		NA											36	133					0	0	0	0
C3orf37	56941	broad.mit.edu	37	3	129020915	129020915	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:129020915C>G	uc003elt.2	+	6	846	c.758C>G	c.(757-759)TCT>TGT	p.S253C	C3orf37_uc003elu.2_Missense_Mutation_p.S211C|C3orf37_uc003elv.2_Missense_Mutation_p.S253C|C3orf37_uc003elw.2_Missense_Mutation_p.S253C	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	253										ovary(1)	1						CATGCAGTCTCTTCTGTGGTG	0.483		NA											15	205					0	0	0	0
TRIM42	287015	broad.mit.edu	37	3	140406816	140406816	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:140406816A>T	uc003eto.1	+	3	1483	c.1292A>T	c.(1291-1293)AAG>ATG	p.K431M		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	431						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						GCCTACTCCAAGGAAGCCCTG	0.502		NA											7	75					0	0	0	0
ZIC4	84107	broad.mit.edu	37	3	147108849	147108849	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:147108849C>T	uc003ewd.1	-	4	1146	c.873G>A	c.(871-873)TCG>TCA	p.S291S	ZIC4_uc003ewc.1_Silent_p.S221S|ZIC4_uc011bno.1_Silent_p.S341S	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	291						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TGGGCGGCGGCGAGCGCCCGT	0.672		NA											14	55					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	151105633	151105633	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:151105633G>A	uc003eyp.2	+	35	5057	c.5019G>A	c.(5017-5019)CCG>CCA	p.P1673P	MED12L_uc011bnz.1_Silent_p.P1533P|MED12L_uc003eyy.1_Silent_p.P836P	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1673					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGTGTCCCCGTGGGACTTGT	0.532		NA											15	119					0	0	0	0
PSMD2	5708	broad.mit.edu	37	3	184018206	184018206	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:184018206G>C	uc003fnn.1	+	3	364	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	PSMD2_uc011brj.1_5'Flank|PSMD2_uc011brk.1_5'Flank	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	111					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GGAAATCTATGAGAACATGGC	0.458		NA											12	117					0	0	0	0
IL1RAP	3556	broad.mit.edu	37	3	190362143	190362143	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:190362143C>T	uc003fsm.1	+	10	1364	c.1158C>T	c.(1156-1158)GTC>GTT	p.V386V	IL1RAP_uc010hzg.1_Silent_p.V386V|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.V386V|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Silent_p.V386V	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	386	Helical; (Potential).				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TAGAGATGGTCCTATTTTACC	0.398		NA											17	87					0	0	0	0
RNF168	165918	broad.mit.edu	37	3	196198801	196198801	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:196198801C>T	uc003fwq.2	-	6	2143	c.1605G>A	c.(1603-1605)AAG>AAA	p.K535K	RNF168_uc010iah.2_Silent_p.K368K|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	535					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		AATTTGGCATCTTTCTTCTAT	0.398		NA											11	450					0	0	0	0
RBPJ	3516	broad.mit.edu	37	4	26422343	26422343	+	Silent	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:26422343T>C	uc003grx.1	+	6	767	c.531T>C	c.(529-531)GCT>GCC	p.A177A	RBPJ_uc003gry.1_Silent_p.A162A|RBPJ_uc003grz.1_Silent_p.A177A|RBPJ_uc011bxt.1_Silent_p.A177A|RBPJ_uc003gsa.1_Silent_p.A163A|RBPJ_uc003gsb.1_Silent_p.A164A|RBPJ_uc003gsc.1_Silent_p.A163A	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	177					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				TGAAAAATGCTGACTGTATGT	0.353		NA											43	31					0	0	0	0
N4BP2	55728	broad.mit.edu	37	4	40123657	40123657	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:40123657T>C	uc003guy.3	+	9	4264	c.3926T>C	c.(3925-3927)CTT>CCT	p.L1309P	N4BP2_uc010ifq.2_Missense_Mutation_p.L1229P|N4BP2_uc010ifr.2_Missense_Mutation_p.L1229P	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1309						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						ACTGATTCTCTTGAAATAAAG	0.259		NA											3	34					0	0	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182127	57182127	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:57182127C>T	uc003hbk.2	+	8	2850	c.2459C>T	c.(2458-2460)TCG>TTG	p.S820L	KIAA1211_uc010iha.2_Missense_Mutation_p.S813L|KIAA1211_uc011bzz.1_Missense_Mutation_p.S730L|KIAA1211_uc003hbm.1_Missense_Mutation_p.S706L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	820										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ACGACCTCGTCGGACAGCGAG	0.532		NA											20	98					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73963824	73963824	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:73963824C>G	uc003hgp.2	-	26	5104	c.4987G>C	c.(4987-4989)GAG>CAG	p.E1663Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.E1550Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.E1412Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.E1662Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1663	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GATTTTCTCTCTTCCTTTGGA	0.363		NA											16	182					0	0	0	0
NHEDC2	133308	broad.mit.edu	37	4	103949913	103949913	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:103949913G>A	uc003hwx.3	-	11	2255	c.1383C>T	c.(1381-1383)GCC>GCT	p.A461A	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Silent_p.A461A|NHEDC2_uc011cew.1_Silent_p.A404A|NHEDC2_uc011cex.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	461					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CCTGAACTGTGGCCTTTGGAA	0.338		NA											10	66					0	0	0	0
NHEDC2	133308	broad.mit.edu	37	4	103949935	103949935	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:103949935G>C	uc003hwx.3	-	11	2233	c.1361C>G	c.(1360-1362)TCT>TGT	p.S454C	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Missense_Mutation_p.S454C|NHEDC2_uc011cew.1_Missense_Mutation_p.S397C|NHEDC2_uc011cex.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	454					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CCATGCAAAAGAAATAAATAT	0.363		NA											9	75					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126336921	126336921	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:126336921T>C	uc003ifj.3	+	5	6803	c.6803T>C	c.(6802-6804)GTC>GCC	p.V2268A	FAT4_uc011cgp.1_Missense_Mutation_p.V566A	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2268	Extracellular (Potential).|Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTGTAAATGTCCCTGAGAAT	0.368		NA											10	81					0	0	0	0
GRIA2	2891	broad.mit.edu	37	4	158284089	158284089	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:158284089G>T	uc003ipm.3	+	15	3004	c.2545G>T	c.(2545-2547)GCA>TCA	p.A849S	GRIA2_uc011cit.1_Missense_Mutation_p.A802S|GRIA2_uc003ipl.3_Missense_Mutation_p.A849S|GRIA2_uc003ipk.3_Missense_Mutation_p.A802S|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	849	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AATGAAGGTGGCAAAGAATGC	0.433		NA											24	102					2.89e-11	3.23e-11	1	0
SEMA5A	9037	broad.mit.edu	37	5	9108255	9108255	+	Silent	SNP	A	A	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:9108255A>G	uc003jek.2	-	16	2782	c.2070T>C	c.(2068-2070)AAT>AAC	p.N690N		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	690	TSP type-1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TACTCACCACATTGCAGCCTG	0.542		NA											13	52					0	0	0	0
MARCH6	10299	broad.mit.edu	37	5	10414543	10414543	+	Splice_Site	SNP	A	A	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:10414543A>T	uc003jet.1	+	20	2080	c.1897_splice	c.e20-2	p.I633_splice	MARCH6_uc011cmu.1_Splice_Site_p.I585_splice|MARCH6_uc003jeu.1_Splice_Site_p.I331_splice|MARCH6_uc011cmv.1_Splice_Site_p.I528_splice	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TTTACTTTGCAGATATTTCTG	0.348		NA											64	112					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24593422	24593422	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:24593422G>C	uc003jgr.1	-	2	510	c.178C>G	c.(178-180)CAA>GAA	p.Q60E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	60	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AAGAAAAATTGATTCCACATC	0.383		NA								HNSCC(23;0.051)			6	236					0	0	0	0
ITGA2	3673	broad.mit.edu	37	5	52347333	52347333	+	Silent	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:52347333G>A	uc003joy.2	+	7	866	c.723G>A	c.(721-723)CAG>CAA	p.Q241Q	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.Q165Q|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	241	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CAACATCCCAGACATCCCAAT	0.373		NA											43	80					0	0	0	0
PIK3R1	5295	broad.mit.edu	37	5	67591278	67591279	+	Nonsense_Mutation	DNP	GA	GA	CT			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:67591278_67591279GA>CT	uc003jva.2	+	14	2336_2337	c.1776_1777GA>CT	c.(1774-1779)AAGAAG>AACTAG	p.592_593KK>N*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.592_593KK>N*|PIK3R1_uc003jvc.2_Nonsense_Mutation_p.292_293KK>N*|PIK3R1_uc003jvd.2_Nonsense_Mutation_p.322_323KK>N*|PIK3R1_uc003jve.2_Nonsense_Mutation_p.271_272KK>N*|PIK3R1_uc011crb.1_Nonsense_Mutation_p.262_263KK>N*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	592_593					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTCGGCAAAAGAAGTTGAACGA	0.361		NA	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			5	73					0	0	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308890	140308890	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:140308890C>A	uc003lih.2	+	1	2589	c.2413C>A	c.(2413-2415)CAC>AAC	p.H805N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.H805N	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	805	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAGGGGATCACGCTAATGT	0.453		NA											22	162					2.45e-14	2.79e-14	1	0
GABRB2	2561	broad.mit.edu	37	5	160973412	160973412	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:160973412C>A	uc003lys.1	-	3	303	c.85G>T	c.(85-87)GAC>TAC	p.D29Y	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Missense_Mutation_p.D29Y|GABRB2_uc003lyt.1_Missense_Mutation_p.D29Y|GABRB2_uc010jiu.1_Intron|GABRB2_uc011dei.1_Missense_Mutation_p.D29Y	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	29	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTACTAGGGTCATTGACACTA	0.443		NA											14	48					2.32e-09	2.55e-09	1	0
CCDC99	54908	broad.mit.edu	37	5	169031117	169031117	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:169031117C>G	uc003mae.3	+	12	2003	c.1724C>G	c.(1723-1725)TCA>TGA	p.S575*	CCDC99_uc011deq.1_Nonsense_Mutation_p.S392*|CCDC99_uc010jjk.2_Nonsense_Mutation_p.S301*	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	575					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAGAAACTTCAAGCAAATTG	0.363		NA											32	81					0	0	0	0
KDM1B	221656	broad.mit.edu	37	6	18207751	18207751	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:18207751C>T	uc003nco.1	+	9	1248	c.1173C>T	c.(1171-1173)CTC>CTT	p.L391L	KDM1B_uc003ncn.1_Silent_p.L362L	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	594					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						ACATTCAACTCAAATCTCCAG	0.517		NA											29	70					0	0	0	0
SKIV2L	6499	broad.mit.edu	37	6	31931233	31931233	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:31931233C>T	uc003nyn.1	+	14	1836	c.1447C>T	c.(1447-1449)CGC>TGC	p.R483C	SKIV2L_uc011dou.1_Missense_Mutation_p.R325C|SKIV2L_uc011dov.1_Missense_Mutation_p.R290C	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	483						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CACTGTAACCCGCCCCGTGCC	0.562		NA											21	89					0	0	0	0
B3GALT4	8705	broad.mit.edu	37	6	33245570	33245570	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:33245570G>T	uc003odr.2	+	1	654	c.374G>T	c.(373-375)GGG>GTG	p.G125V		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	125	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						GGTTCCCAGGGGAGTGACCTG	0.672		NA											44	207					5.2e-24	6e-24	1	0
CUL9	23113	broad.mit.edu	37	6	43155036	43155037	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:43155036_43155037CC>TT	uc003ouk.2	+	6	1515_1516	c.1440_1441CC>TT	c.(1438-1443)TACCTC>TATTTC	p.L481F	CUL9_uc003ouj.1_Intron|CUL9_uc003oul.2_Missense_Mutation_p.L481F|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_Intron	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	481					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CTTTGCCGTACCTCCAGCCCGA	0.54		NA											43	219					0	0	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90572083	90572083	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:90572083G>A	uc003pnr.2	+	7	851	c.655G>A	c.(655-657)GAG>AAG	p.E219K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E219K|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E219K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	219					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TACATCTGTTGAGAAACACTG	0.388		NA											31	231					0	0	0	0
GJA10	84694	broad.mit.edu	37	6	90605064	90605064	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:90605064C>G	uc011eaa.1	+	1	877	c.877C>G	c.(877-879)CGA>GGA	p.R293G		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	293	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GCAAGTCATTCGAGTTAATGT	0.433		NA											10	77					0	0	0	0
EIF3B	8662	broad.mit.edu	37	7	2415133	2415133	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:2415133G>A	uc003slx.2	+	14	2082	c.1999G>A	c.(1999-2001)GTC>ATC	p.V667I	EIF3B_uc003sly.2_Missense_Mutation_p.V667I|EIF3B_uc003sma.2_Missense_Mutation_p.V395I|EIF3B_uc003smb.2_5'Flank	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	667	WD 5.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GCGCTACGTCGTCACCTCTGT	0.562		NA											24	84					0	0	0	0
GHRHR	2692	broad.mit.edu	37	7	31008504	31008504	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:31008504A>G	uc003tbx.2	+	2	161	c.113A>G	c.(112-114)GAG>GGG	p.E38G	GHRHR_uc003tbw.1_Missense_Mutation_p.E38G|GHRHR_uc003tby.2_5'Flank|GHRHR_uc003tbz.2_5'Flank	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	38	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	AGAGAGGATGAGAGTGCCTGT	0.537		NA											11	51					0	0	0	0
MAGI2	9863	broad.mit.edu	37	7	78130931	78130931	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:78130931T>A	uc003ugx.2	-	5	1182	c.928A>T	c.(928-930)ATG>TTG	p.M310L	MAGI2_uc003ugy.2_Missense_Mutation_p.M310L|MAGI2_uc011kgr.1_Missense_Mutation_p.M142L|MAGI2_uc011kgs.1_Missense_Mutation_p.M147L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	310	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GTATAGGCCATTTCCCAGTTA	0.448		NA											23	179					0	0	0	0
SAMD9	54809	broad.mit.edu	37	7	92733477	92733477	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:92733477T>A	uc003umf.2	-	3	2190	c.1934A>T	c.(1933-1935)GAA>GTA	p.E645V	SAMD9_uc003umg.2_Missense_Mutation_p.E645V	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	645						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GATATCTTCTTCCTTTTTCAG	0.353		NA											23	192					0	0	0	0
NPTX2	4885	broad.mit.edu	37	7	98248963	98248963	+	Silent	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:98248963C>G	uc003upl.2	+	2	612	c.435C>G	c.(433-435)CTC>CTG	p.L145L		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	145					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AGCACCAGCTCAGAGCAAACG	0.607		NA											57	135					0	0	0	0
OR2A7	401427	broad.mit.edu	37	7	143956646	143956646	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:143956646G>A	uc011kuc.1	-	1	76	c.76C>T	c.(76-78)CTC>TTC	p.L26F	OR2A9P_uc003wec.1_Intron|OR2A7_uc003wef.2_3'UTR	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					AGCCCAAAGAGGAGCATCTGA	0.527		NA											10	73					0	0	0	0
EFHA2	286097	broad.mit.edu	37	8	16956031	16956031	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:16956031C>T	uc003wxd.2	+	9	995	c.953C>T	c.(952-954)ACA>ATA	p.T318I		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	318						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		AGACGTAACACAAGCCAAGCA	0.383		NA											53	140					0	0	0	0
UNC5D	137970	broad.mit.edu	37	8	35608198	35608198	+	Silent	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:35608198C>A	uc003xjr.1	+	13	2362	c.2034C>A	c.(2032-2034)CTC>CTA	p.L678L	UNC5D_uc003xjs.1_Silent_p.L673L|UNC5D_uc003xju.1_Silent_p.L254L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	678	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCTATGCGCTCACTGGAGAGC	0.498		NA											45	284					1.97e-11	2.22e-11	1	0
KIAA0146	23514	broad.mit.edu	37	8	48309175	48309175	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:48309175G>C	uc003xqd.2	+	6	774	c.765G>C	c.(763-765)AAG>AAC	p.K255N	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Missense_Mutation_p.K255N|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.K185N|KIAA0146_uc011ldd.1_Missense_Mutation_p.K195N|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	255											0		Lung NSC(58;0.175)				CAGCAAAGAAGAAGCTTTTAA	0.313		NA											88	174					0	0	0	0
XKR4	114786	broad.mit.edu	37	8	56015448	56015448	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:56015448G>A	uc003xsf.2	+	1	432	c.400G>A	c.(400-402)GTG>ATG	p.V134M		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	134	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CTGGCTCGCCGTGGACTACTA	0.662		NA											7	118					0	0	0	0
XKR4	114786	broad.mit.edu	37	8	56015674	56015674	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:56015674C>A	uc003xsf.2	+	1	658	c.626C>A	c.(625-627)CCT>CAT	p.P209H		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	209						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			GAGGCTCGTCCTTCCACGCCG	0.692		NA											22	38					2.89e-11	3.23e-11	1	0
GSDMC	56169	broad.mit.edu	37	8	130789715	130789715	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:130789715C>T	uc003ysr.2	-	2	1001	c.119G>A	c.(118-120)CGA>CAA	p.R40Q		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	40						mitochondrion				ovary(2)|skin(1)	3						CTTCTTCTTTCGTAATATAAC	0.398		NA											30	174					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139180196	139180196	+	Silent	SNP	G	G	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:139180196G>T	uc003yuy.2	-	12	1371	c.1200C>A	c.(1198-1200)GGC>GGA	p.G400G	FAM135B_uc003yux.2_Silent_p.G301G|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	400										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGTTCCAATCGCCGTCGATGT	0.552		NA								HNSCC(54;0.14)			60	159					5.11e-33	5.93e-33	1	0
NTRK2	4915	broad.mit.edu	37	9	87339210	87339210	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:87339210C>G	uc004aoa.1	+	10	1730	c.792C>G	c.(790-792)ATC>ATG	p.I264M	NTRK2_uc004anv.1_Missense_Mutation_p.I264M|NTRK2_uc004any.1_Missense_Mutation_p.I264M|NTRK2_uc004anz.1_Missense_Mutation_p.I264M|NTRK2_uc011lsz.1_Missense_Mutation_p.I264M|NTRK2_uc011lta.1_Missense_Mutation_p.I264M|NTRK2_uc004aob.1_Missense_Mutation_p.I264M|NTRK2_uc011ltb.1_Missense_Mutation_p.I108M	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	264	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						GGAAGCAGATCTCTTGTGTGG	0.393		NA								TSP Lung(25;0.17)			12	249					0	0	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111745497	111745497	+	Silent	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:111745497C>T	uc004bdo.1	-	6	870	c.828G>A	c.(826-828)GTG>GTA	p.V276V	CTNNAL1_uc010mts.1_Silent_p.V12V|CTNNAL1_uc010mtt.1_Silent_p.V276V|CTNNAL1_uc004bdp.1_Silent_p.V276V	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	276					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		TACAGTCAGTCACAATTTCAA	0.353		NA											6	64					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139402755	139402755	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:139402755C>T	uc004chz.2	-	20	3254	c.3254G>A	c.(3253-3255)TGC>TAC	p.C1085Y	NOTCH1_uc004cia.1_Missense_Mutation_p.C315Y	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1085	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCGCTGGGGCACTCGCAGCG	0.647		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			33	58					0	0	0	0
BEND2	139105	broad.mit.edu	37	X	18234753	18234753	+	Silent	SNP	T	T	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:18234753T>A	uc004cyj.3	-	2	280	c.126A>T	c.(124-126)ATA>ATT	p.I42I	BEND2_uc010nfb.2_Silent_p.I42I	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	42										ovary(3)|kidney(1)|central_nervous_system(1)	5						AATCATCTGCTATGTCATTAG	0.418		NA											26	33					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32482777	32482777	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:32482777C>T	uc004dda.1	-	24	3446	c.3202G>A	c.(3202-3204)GAT>AAT	p.D1068N	DMD_uc004dcz.2_Missense_Mutation_p.D945N|DMD_uc004dcy.1_Missense_Mutation_p.D1064N|DMD_uc004ddb.1_Missense_Mutation_p.D1060N|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1068	Spectrin 7.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGAAAAACATCAACTTCAGCC	0.388		NA											12	84					0	0	0	0
TFE3	7030	broad.mit.edu	37	X	48888064	48888064	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:48888064G>C	uc004dmb.3	-	10	1571	c.1333C>G	c.(1333-1335)CCA>GCA	p.P445A	TFE3_uc004dmc.3_Missense_Mutation_p.P340A	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	445					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						AGCAGCCCTGGAGTGGGAGGT	0.577		NA	T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								13	29					0	0	0	0
TFE3	7030	broad.mit.edu	37	X	48888088	48888088	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:48888088G>A	uc004dmb.3	-	10	1547	c.1309C>T	c.(1309-1311)CAT>TAT	p.H437Y	TFE3_uc004dmc.3_Missense_Mutation_p.H332Y	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	437					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						GGCAGGCCATGGATCTGGGCC	0.547		NA	T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								10	32					0	0	0	0
HDX	139324	broad.mit.edu	37	X	83723928	83723928	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:83723928A>G	uc004eek.1	-	3	912	c.803T>C	c.(802-804)TTG>TCG	p.L268S	HDX_uc011mqv.1_Missense_Mutation_p.L268S|HDX_uc004eel.1_Missense_Mutation_p.L210S	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCTAACTGCCAATGAAAACAC	0.453		NA											51	74					0	0	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413786	61413788	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:61413786_61413788delCTT	uc010qig.1	-	5	1445_1447	c.996_998delAAG	c.(994-999)AGAAGT>AGT	p.R332del		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	332	Cytoplasmic (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						CACGTTTGAACTTCTTGCTACAT	0.365		NA											11	99	---	---	---	---	NA	NA	NA	NA
TCP11L1	55346	broad.mit.edu	37	11	33079527	33079527	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:33079527delG	uc001mud.2	+	5	880	c.480delG	c.(478-480)TTGfs	p.L160fs	TCP11L1_uc009yju.2_5'UTR|TCP11L1_uc010rei.1_Frame_Shift_Del_p.L160fs|TCP11L1_uc001mue.2_Frame_Shift_Del_p.L160fs|TCP11L1_uc001muf.1_5'Flank	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	160											0						CAGAAGTCTTGGATCTGGATC	0.433		NA											12	68	---	---	---	---	NA	NA	NA	NA
CNTNAP5	129684	broad.mit.edu	37	2	125284919	125284921	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:125284919_125284921delGCT	uc002tno.2	+	10	1896_1898	c.1532_1534delGCT	c.(1531-1536)GGCTGC>GGC	p.C512del	CNTNAP5_uc010flu.2_In_Frame_Del_p.C513del	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	512	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCTTTCCAAGGCTGCATGAGGCT	0.433		NA											12	101	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179600777	179600778	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179600777_179600778delGA	uc010zfg.1	-	47	10887_10888	c.10663_10664delTC	c.(10663-10665)TCCfs	p.S3555fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.S216fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4482							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTAGGTCTGGAGAGAAAGGTT	0.431		NA											29	92	---	---	---	---	NA	NA	NA	NA
SATB2	23314	broad.mit.edu	37	2	200213543	200213544	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:200213543_200213544insT	uc002uuy.1	-	7	1870_1871	c.1053_1054insA	c.(1051-1056)CCAGAGfs	p.P351fs	SATB2_uc010fsq.1_Frame_Shift_Ins_p.P233fs|SATB2_uc002uuz.1_Frame_Shift_Ins_p.P351fs|SATB2_uc002uva.1_Frame_Shift_Ins_p.P351fs|SATB2_uc002uvb.1_Frame_Shift_Ins_p.P94fs	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	351_352	CUT 1.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGGTTGGCTCTGGCTTAACTG	0.54		NA											59	181	---	---	---	---	NA	NA	NA	NA
PRDM15	63977	broad.mit.edu	37	21	43221744	43221745	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:43221744_43221745insA	uc002yzq.1	-	31	4290_4291	c.4179_4180insT	c.(4177-4182)CTTACCfs	p.L1393fs	PRDM15_uc002yzo.2_Frame_Shift_Ins_p.L1064fs|PRDM15_uc002yzp.2_Frame_Shift_Ins_p.L1084fs|PRDM15_uc002yzr.1_Frame_Shift_Ins_p.L1084fs	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1393_1394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAGGGGTGGTAAGGTGCCCCA	0.579		NA											15	38	---	---	---	---	NA	NA	NA	NA
APOL4	80832	broad.mit.edu	37	22	36595382	36595392	+	Frame_Shift_Del	DEL	ACTGTCCAGCC	ACTGTCCAGCC	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:36595382_36595392delACTGTCCAGCC	uc003aox.2	-	3	300_310	c.75_85delGGCTGGACAGT	c.(73-87)GTGGCTGGACAGTTCfs	p.V25fs	APOL4_uc003aow.2_Frame_Shift_Del_p.V22fs|APOL4_uc010gww.2_5'UTR|APOL4_uc003aoy.2_RNA	NM_145660	NP_663693	Q9BPW4	APOL4_HUMAN	apolipoprotein L4 isoform 2 precursor	25_29					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding				0						TTACCTTGGAACTGTCCAGCCACTGTCCAGC	0.54		NA											7	75	---	---	---	---	NA	NA	NA	NA
SENP6	26054	broad.mit.edu	37	6	76412714	76412714	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:76412714delC	uc003pid.3	+	19	3261	c.2642delC	c.(2641-2643)TCCfs	p.S881fs	SENP6_uc003pie.3_Frame_Shift_Del_p.S874fs|SENP6_uc010kbf.2_Intron	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	881	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GAATCTACATCCCAGAAAGTT	0.328		NA											60	282	---	---	---	---	NA	NA	NA	NA
ABP1	26	broad.mit.edu	37	7	150553769	150553780	+	In_Frame_Del	DEL	CTCATCGAGATG	CTCATCGAGATG	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:150553769_150553780delCTCATCGAGATG	uc003why.1	+	3	4429_4440	c.211_222delCTCATCGAGATG	c.(211-222)CTCATCGAGATGdel	p.LIEM71del	ABP1_uc003whz.1_In_Frame_Del_p.LIEM71del|ABP1_uc003wia.1_In_Frame_Del_p.LIEM71del	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	71_74					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CACCGTGTTTCTCATCGAGATGCTGCTGCCCA	0.557		NA											14	161	---	---	---	---	NA	NA	NA	NA
PIWIL2	55124	broad.mit.edu	37	8	22172591	22172591	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:22172591delC	uc003xbn.2	+	18	2289	c.2141delC	c.(2140-2142)GCCfs	p.A714fs	PIWIL2_uc011kzf.1_Frame_Shift_Del_p.A714fs|PIWIL2_uc010ltv.2_Frame_Shift_Del_p.A714fs	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	714	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CGGAGTGTGGCCCAGAAGATT	0.483		NA											29	89	---	---	---	---	NA	NA	NA	NA
