Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
RERE	473	broad.mit.edu	37	1	8421855	8421855	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:8421855C>T	uc001ape.2	-	18	2794	c.1984G>A	c.(1984-1986)GAC>AAC	p.D662N	RERE_uc001apf.2_Missense_Mutation_p.D662N|RERE_uc010nzx.1_Missense_Mutation_p.D394N|RERE_uc001apd.2_Missense_Mutation_p.D108N	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	662					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGGTCCTGTCAGCCTCCTCC	0.552		NA											47	107					0	0	0	0
SLC2A5	6518	broad.mit.edu	37	1	9101976	9101976	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:9101976G>C	uc001apo.2	-	5	731	c.439C>G	c.(439-441)CCC>GCC	p.P147A	SLC2A5_uc010nzy.1_Missense_Mutation_p.P88A|SLC2A5_uc010nzz.1_Missense_Mutation_p.P32A|SLC2A5_uc010oaa.1_Missense_Mutation_p.P103A|SLC2A5_uc010oab.1_Missense_Mutation_p.P147A|SLC2A5_uc010oac.1_Missense_Mutation_p.P105R|SLC2A5_uc001app.3_Missense_Mutation_p.P147A	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	147	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTACATGGGGACCACGTTG	0.512		NA											12	39					0	0	0	0
NBPF3	84224	broad.mit.edu	37	1	21808093	21808093	+	Silent	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:21808093C>A	uc001ber.2	+	13	1787	c.1437C>A	c.(1435-1437)CTC>CTA	p.L479L	NBPF3_uc001bes.2_Silent_p.L423L|NBPF3_uc009vqb.2_Silent_p.L467L|NBPF3_uc010odm.1_Silent_p.L409L	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	479	NBPF 4.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTTCCAGGCTCAGCAGAGAGC	0.458		NA											44	106					1.03e-13	1.14e-13	1	0
CELA3B	23436	broad.mit.edu	37	1	22313044	22313044	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:22313044C>T	uc001bfk.2	+	7	778	c.663C>T	c.(661-663)CTC>CTT	p.L221L	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	221	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GAGGACCCCTCAACTGCCCCA	0.572		NA											7	96					0	0	0	0
ZNF436	80818	broad.mit.edu	37	1	23688794	23688795	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:23688794_23688795GC>AA	uc001bgt.2	-	3	1461_1462	c.1080_1081GC>TT	c.(1078-1083)AAGCCA>AATTCA	p.360_361KP>NS	ZNF436_uc001bgu.2_Missense_Mutation_p.360_361KP>NS	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	360_361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CATTCATATGGCTTCTCTCCAG	0.48		NA											121	154					0	0	0	0
NIPAL3	57185	broad.mit.edu	37	1	24766687	24766687	+	Missense_Mutation	SNP	C	C	T	rs143586098		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:24766687C>T	uc001bjh.2	+	3	526	c.119C>T	c.(118-120)GCG>GTG	p.A40V	NIPAL3_uc010oek.1_Missense_Mutation_p.A40V|NIPAL3_uc001bjg.2_Missense_Mutation_p.A40V|NIPAL3_uc009vrc.2_5'UTR	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	40	Helical; (Potential).					integral to membrane					0						GCCCTCTTGGCGATCTTCGGG	0.537		NA											41	108					0	0	0	0
PPIE	10450	broad.mit.edu	37	1	40214724	40214724	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:40214724G>A	uc001cds.1	+	8	701	c.658G>A	c.(658-660)GAT>AAT	p.D220N	PPIE_uc001cdt.1_Missense_Mutation_p.D154N|PPIE_uc010oiy.1_Missense_Mutation_p.D141N|PPIE_uc001cdu.1_RNA|PPIE_uc001cdv.2_Missense_Mutation_p.D220N|PPIE_uc001cdw.2_Missense_Mutation_p.D220N|PPIE_uc001cdx.1_Missense_Mutation_p.D136N	NM_006112	NP_006103	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E isoform 1	220	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding				0	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGAAGTTCGATGATGAAAA	0.552		NA											51	94					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44069435	44069435	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:44069435G>A	uc001cjr.2	+	16	2952	c.2612G>A	c.(2611-2613)GGC>GAC	p.G871D	PTPRF_uc001cjs.2_Missense_Mutation_p.G862D|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.G431D|PTPRF_uc001cjv.2_Missense_Mutation_p.G331D|PTPRF_uc001cjw.2_Missense_Mutation_p.G97D	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	871	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATAGATTTCGGCAAGGATGAC	0.637		NA											35	85					0	0	0	0
MAST2	23139	broad.mit.edu	37	1	46500768	46500768	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:46500768G>T	uc001cov.2	+	29	4710	c.4427G>T	c.(4426-4428)CGG>CTG	p.R1476L	MAST2_uc001cow.2_Missense_Mutation_p.R1475L|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1476					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GCTCCCTCACGGGCCCTAGGC	0.662		NA											21	40					5.26e-13	5.81e-13	1	0
MYSM1	114803	broad.mit.edu	37	1	59147716	59147716	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:59147716C>T	uc009wab.1	-	8	1023	c.1000G>A	c.(1000-1002)GAT>AAT	p.D334N	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	334					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TGCCTGGCATCAACTATTATT	0.348		NA											79	174					0	0	0	0
CACHD1	57685	broad.mit.edu	37	1	65117854	65117854	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:65117854G>A	uc001dbo.1	+	10	1353	c.1248G>A	c.(1246-1248)ATG>ATA	p.M416I	CACHD1_uc001dbp.1_Missense_Mutation_p.M171I|CACHD1_uc001dbq.1_Missense_Mutation_p.M171I	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	467	Extracellular (Potential).|Cache 1.				calcium ion transport	integral to membrane				ovary(2)	2						GTTTGATAATGACTGTGAGTA	0.403		NA											49	113					0	0	0	0
GADD45A	1647	broad.mit.edu	37	1	68153400	68153400	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:68153400C>T	uc001ddz.1	+	4	736	c.441C>T	c.(439-441)TGC>TGT	p.C147C	GADD45A_uc009wbb.1_Silent_p.C113C|GADD45A_uc009wbc.1_RNA|GADD45A_uc009wbd.1_RNA	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	147					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						TTTGTTTTTGCCGGGAAAGTC	0.353		NA											4	239					0	0	0	0
CLCA2	9635	broad.mit.edu	37	1	86919091	86919091	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:86919091G>A	uc001dlr.3	+	13	2357	c.2195G>A	c.(2194-2196)AGA>AAA	p.R732K		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	732	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCAGTAGGCAGAAATGAGGAG	0.453		NA											4	108					0	0	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049934	90049934	+	Silent	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:90049934G>T	uc001dni.2	+	7	2232	c.1725G>T	c.(1723-1725)CTG>CTT	p.L575L	LRRC8B_uc001dnh.2_Silent_p.L575L|LRRC8B_uc001dnj.2_Silent_p.L575L	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	575	LRR 5.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GAAGCAAACTGGTTGTGTTGA	0.463		NA											4	94					0.00909568	0.00942467	1	0
SARS	6301	broad.mit.edu	37	1	109778722	109778722	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:109778722G>T	uc001dwu.1	+	8	1168	c.1093G>T	c.(1093-1095)GTC>TTC	p.V365F	SARS_uc001dwt.1_Missense_Mutation_p.V365F|SARS_uc001dwv.1_Missense_Mutation_p.V365F|SARS_uc001dww.1_Missense_Mutation_p.V298F|SARS_uc001dwx.1_Missense_Mutation_p.V317F|SARS_uc009wfa.1_Missense_Mutation_p.V365F|SARS_uc001dwy.1_Missense_Mutation_p.V190F|SARS_uc001dwz.1_Missense_Mutation_p.V190F	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	365					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGTGAATATTGTCTCAGGTAT	0.507		NA											63	84					1.43e-28	1.65e-28	1	0
ADORA3	140	broad.mit.edu	37	1	112031598	112031598	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:112031598G>A	uc001ebf.2	-	3	1273	c.506C>T	c.(505-507)ACG>ATG	p.T169M	ADORA3_uc001ebg.3_Missense_Mutation_p.T88M	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCAGAAGCCGTGTCCAGCAC	0.398		NA											33	80					0	0	0	0
SYCP1	6847	broad.mit.edu	37	1	115489931	115489931	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:115489931G>A	uc001efr.2	+	27	2521	c.2312G>A	c.(2311-2313)AGA>AAA	p.R771K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.R771K|SYCP1_uc009wgw.2_Intron	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	771	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAATAGAAAGAGAAGAGAAG	0.294		NA											43	116					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118567969	118567969	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:118567969C>A	uc001ehk.2	-	27	3869	c.3801G>T	c.(3799-3801)AAG>AAT	p.K1267N		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1267						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACTCATAGTGCTTCACCCTCT	0.458		NA											71	151					2.73e-36	3.21e-36	1	0
NBPF7	343505	broad.mit.edu	37	1	120384093	120384093	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:120384093C>G	uc010oxk.1	-	3	1090	c.469G>C	c.(469-471)GAC>CAC	p.D157H		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	157						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TGGGAGTTGTCATGCTTATCC	0.577		NA											5	304					0	0	0	0
NBPF9	400818	broad.mit.edu	37	1	144621623	144621623	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:144621623G>T	uc009wig.1	+	9	1031	c.955G>T	c.(955-957)GCC>TCC	p.A319S	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.A319S|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.A250S|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.A250S|NBPF9_uc010oyg.1_Missense_Mutation_p.A284S|NBPF9_uc009wii.1_Missense_Mutation_p.A48S	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	319						cytoplasm					0						AACTCAACTGGCCGGCTTCCT	0.428		NA											5	397					3.6e-05	3.82e-05	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244		NA											4	213					0	0	0	0
SV2A	9900	broad.mit.edu	37	1	149879361	149879361	+	Silent	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:149879361T>C	uc001etg.2	-	10	2060	c.1569A>G	c.(1567-1569)TCA>TCG	p.S523S	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.S523S	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	523	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAAAGGACACTGACTTGAGCC	0.488		NA											29	113					0	0	0	0
ECM1	1893	broad.mit.edu	37	1	150484939	150484939	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150484939C>T	uc001eus.2	+	8	1394	c.1195C>T	c.(1195-1197)CGG>TGG	p.R399W	ECM1_uc001eut.2_Missense_Mutation_p.R274W|ECM1_uc001euu.2_Missense_Mutation_p.R428W|ECM1_uc001euv.2_Missense_Mutation_p.R426W|ECM1_uc009wlu.2_Missense_Mutation_p.R159W	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	399	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTTGCCCGTCGGGCTCCTTA	0.567		NA											59	173					0	0	0	0
LASS2	29956	broad.mit.edu	37	1	150940906	150940906	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150940906G>A	uc001evy.2	-	3	643	c.256C>T	c.(256-258)CAT>TAT	p.H86Y	LASS2_uc001evz.2_Missense_Mutation_p.H86Y|LASS2_uc009wmh.2_5'UTR	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	86	Cytoplasmic (Potential).|Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGTAGAAATGTTCCAAGGTG	0.572		NA											42	89					0	0	0	0
OR10K1	391109	broad.mit.edu	37	1	158436255	158436255	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:158436255C>G	uc010pij.1	+	1	904	c.904C>G	c.(904-906)CGA>GGA	p.R302G		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATCAGCCCTACGAAGAACAAT	0.264		NA											46	135					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196712640	196712640	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:196712640G>A	uc001gtj.3	+	20	3432	c.3192G>A	c.(3190-3192)ATG>ATA	p.M1064I		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1064	Sushi 18.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CGAGACAGATGAGTAAATATC	0.403		NA											68	189					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197112028	197112028	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:197112028C>G	uc001gtu.2	-	3	1611	c.1354G>C	c.(1354-1356)GAA>CAA	p.E452Q	ASPM_uc001gtv.2_Missense_Mutation_p.E452Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	452					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACTAGTTCTTCAAAAATAGCT	0.338		NA											6	289					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198721488	198721488	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:198721488G>A	uc001gur.1	+	30	3492	c.3312G>A	c.(3310-3312)CTG>CTA	p.L1104L	PTPRC_uc001gus.1_Silent_p.L1056L|PTPRC_uc001gut.1_Silent_p.L943L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1104	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TCTTTGAACTGAGACATTCCA	0.378		NA											19	148					0	0	0	0
AGAP4	119016	broad.mit.edu	37	10	46322371	46322371	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:46322371G>A	uc001jcx.3	-	7	1110	c.984C>T	c.(982-984)GCC>GCT	p.A328A	AGAP4_uc010qfl.1_Silent_p.A351A|AGAP4_uc001jcy.3_Silent_p.A243A	NM_133446	NP_597703	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	328	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TGGGTGTGCAGGCCGATGTGG	0.488		NA											72	216					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63851964	63851964	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:63851964G>A	uc001jlt.1	+	10	2768	c.2742G>A	c.(2740-2742)CCG>CCA	p.P914P		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	914					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CCAAGAACCCGCACAAACCTA	0.572		NA											5	255					0	0	0	0
KIAA1274	27143	broad.mit.edu	37	10	72324152	72324152	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:72324152G>A	uc001jrd.3	+	19	2576	c.2295G>A	c.(2293-2295)CGG>CGA	p.R765R	KIAA1274_uc001jre.3_Silent_p.R56R	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	765										ovary(2)|central_nervous_system(1)	3						AAGAAATGCGGAGGCTGCAGC	0.617		NA											31	131					0	0	0	0
UNC5B	219699	broad.mit.edu	37	10	73050857	73050857	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:73050857G>A	uc001jro.2	+	9	1730	c.1285G>A	c.(1285-1287)GCA>ACA	p.A429T	UNC5B_uc001jrp.2_Missense_Mutation_p.A418T	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	429	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CTTTAAGACGGCAAGGCCCAG	0.597		NA											6	451					0	0	0	0
SCD	6319	broad.mit.edu	37	10	102114253	102114253	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:102114253C>A	uc001kqy.2	+	4	1001	c.511C>A	c.(511-513)CAT>AAT	p.H171N		NM_005063	NP_005054	O00767	ACOD_HUMAN	stearoyl-CoA desaturase 1	171	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity				0		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TGCTGATCCTCATAATTCCCG	0.502		NA											69	163					3.31e-33	3.87e-33	1	0
FBXW4	6468	broad.mit.edu	37	10	103432746	103432746	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:103432746G>A	uc001kto.2	-	4	947	c.601C>T	c.(601-603)CAT>TAT	p.H201Y		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	201	WD 2.				ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCTGTTCATGAGCCGAGTAC	0.507		NA											42	74					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117704253	117704253	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:117704253G>T	uc001lcg.2	+	29	4489	c.4103G>T	c.(4102-4104)CGA>CTA	p.R1368L	ATRNL1_uc010qsm.1_Missense_Mutation_p.R497L|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1368	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTCCGGAATCGAAAACACCTT	0.418		NA											69	142					1.78e-30	2.06e-30	1	0
SYT8	90019	broad.mit.edu	37	11	1858221	1858221	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:1858221G>A	uc001lue.1	+	8	995	c.867G>A	c.(865-867)CAG>CAA	p.Q289Q	SYT8_uc001lud.2_Silent_p.Q289Q|SYT8_uc001luf.1_Silent_p.Q275Q|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	289	C2 2.|Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCTGAACCAGAGGAAGTGGA	0.627		NA											8	89					0	0	0	0
TSPAN32	10077	broad.mit.edu	37	11	2335794	2335794	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:2335794C>T	uc001lvy.1	+	6	673	c.536C>T	c.(535-537)GCG>GTG	p.A179V	TSPAN32_uc001lvx.1_3'UTR|TSPAN32_uc009ydk.1_Missense_Mutation_p.A189V|TSPAN32_uc010qxk.1_Missense_Mutation_p.A214V|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Missense_Mutation_p.A149V|TSPAN32_uc001lwb.1_Missense_Mutation_p.A149V|TSPAN32_uc001lwc.1_Missense_Mutation_p.A124V|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	179					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GAGGAGGCGGCGAGAGAGGTG	0.652		NA											9	7					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30032952	30032952	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:30032952T>A	uc001msk.2	-	2	2426	c.1274A>T	c.(1273-1275)CAG>CTG	p.Q425L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	425						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCCTGTTGCTGGGCCAGGTC	0.507		NA											57	44					0	0	0	0
OR4C16	219428	broad.mit.edu	37	11	55340373	55340373	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:55340373C>A	uc010rih.1	+	1	770	c.770C>A	c.(769-771)ACA>AAA	p.T257K		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	257	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TTTATGTACACATGCCTTGCA	0.398		NA											53	109					3.77e-23	4.29e-23	1	0
OR5M10	390167	broad.mit.edu	37	11	56344940	56344940	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:56344940G>A	uc001niz.1	-	1	258	c.258C>T	c.(256-258)CTC>CTT	p.L86L		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTGTTCTGAGAGGAAATTGT	0.438		NA											44	86					0	0	0	0
PCNXL3	399909	broad.mit.edu	37	11	65383829	65383829	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:65383829C>T	uc001oey.2	+	1	47	c.47C>T	c.(46-48)TCG>TTG	p.S16L	MAP3K11_uc001oew.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	16						integral to membrane					0						GTGTGGGCCTCGCTCACCGGC	0.667		NA											9	9					0	0	0	0
NUDT8	254552	broad.mit.edu	37	11	67395614	67395615	+	Missense_Mutation	DNP	GG	GG	TA			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:67395614_67395615GG>TA	uc001omo.1	-	4	532_533	c.513_514CC>TA	c.(511-516)TTCCTG>TTTATG	p.L172M	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	172	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding				0						GGTCCATGCAGGAAGACGGGTA	0.639		NA											28	132					0	0	0	0
FOLR1	2348	broad.mit.edu	37	11	71906662	71906662	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:71906662C>T	uc001orz.1	+	5	502	c.364C>T	c.(364-366)CAG>TAG	p.Q122*	FOLR1_uc001osa.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osb.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osc.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osd.1_Nonsense_Mutation_p.Q122*	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	122					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						CCAGGTGGATCAGAGCTGGCG	0.542		NA											28	199					0	0	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021005	73021005	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:73021005G>A	uc001otu.2	+	1	1343	c.1322G>A	c.(1321-1323)GGC>GAC	p.G441D		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	441					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGACCTGGAGGCACCTCTAGG	0.607		NA											37	29					0	0	0	0
TYR	7299	broad.mit.edu	37	11	88911535	88911535	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:88911535C>T	uc001pcs.2	+	1	496	c.414C>T	c.(412-414)CTC>CTT	p.L138L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	138	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TTGCCTACCTCACTTTAGCAA	0.438		NA							Oculocutaneous_Albinism				13	136					0	0	0	0
HEPN1	641654	broad.mit.edu	37	11	124789685	124789685	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:124789685T>A	uc001qbj.1	+	1	540	c.39T>A	c.(37-39)GAT>GAA	p.D13E	HEPACAM_uc009zbj.2_3'UTR|HEPACAM_uc001qbk.2_3'UTR	NM_001037558	NP_001032647	Q6WQI6	HEPN1_HUMAN	HEPACAM opposite strand 1	13						cytoplasm					0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		CATGGGTTGATGGCGAATCAG	0.517		NA											39	37					0	0	0	0
CACNA1C	775	broad.mit.edu	37	12	2595407	2595407	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:2595407T>C	uc009zdu.1	+	6	1208	c.895T>C	c.(895-897)TAC>CAC	p.Y299H	CACNA1C_uc009zdv.1_Missense_Mutation_p.Y299H|CACNA1C_uc001qkb.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkc.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qke.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkf.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qjz.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkd.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkg.2_Missense_Mutation_p.Y299H|CACNA1C_uc009zdw.1_Missense_Mutation_p.Y299H|CACNA1C_uc001qkh.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkl.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkn.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qko.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkp.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkr.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qku.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkq.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qks.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkt.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkj.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkk.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkm.1_Missense_Mutation_p.Y35H	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	299	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAAGACCTGCTACAACCAGGA	0.602		NA											16	61					0	0	0	0
CLEC4E	26253	broad.mit.edu	37	12	8689784	8689784	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:8689784G>A	uc001quo.1	-	4	464	c.299C>T	c.(298-300)TCC>TTC	p.S100F		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	100	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TAACGCCCAGGAAATGGTGTC	0.463		NA											47	77					0	0	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577111	14577111	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:14577111T>C	uc001rbw.2	+	2	420	c.262T>C	c.(262-264)TGG>CGG	p.W88R	ATF7IP_uc010shs.1_Missense_Mutation_p.W88R|ATF7IP_uc001rbu.2_Missense_Mutation_p.W88R|ATF7IP_uc001rbv.1_Missense_Mutation_p.W88R|ATF7IP_uc001rbx.2_Missense_Mutation_p.W88R|ATF7IP_uc010sht.1_Missense_Mutation_p.W88R|ATF7IP_uc001rby.3_Missense_Mutation_p.W88R|ATF7IP_uc001rbz.1_Missense_Mutation_p.W88R|ATF7IP_uc001rca.2_Missense_Mutation_p.W88R|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	88					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TAAAGCAGAATGGAAGGAAAC	0.378		NA											34	67					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49445126	49445126	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:49445126G>T	uc001rta.3	-	10	2340	c.2340C>A	c.(2338-2340)TGC>TGA	p.C780*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	780	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGGCACAGCGCATAGGCATG	0.667		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			27	39					1.3e-26	1.5e-26	1	0
HOXC9	3225	broad.mit.edu	37	12	54396297	54396297	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:54396297G>A	uc001sep.2	+	3	720	c.622G>A	c.(622-624)GAG>AAG	p.E208K	HOXC9_uc001seq.2_Missense_Mutation_p.E208K	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	208	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						GCTGGAACTGGAGAAGGAGTT	0.557		NA											62	119					0	0	0	0
R3HDM2	22864	broad.mit.edu	37	12	57648863	57648863	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:57648863G>A	uc009zpm.1	-	22	2659	c.2624C>T	c.(2623-2625)CCT>CTT	p.P875L	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Missense_Mutation_p.P570L|R3HDM2_uc001snr.2_Missense_Mutation_p.P602L|R3HDM2_uc001sns.2_Missense_Mutation_p.P875L|R3HDM2_uc001snt.2_Missense_Mutation_p.P889L|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	875						nucleus	nucleic acid binding			ovary(2)	2						GATGCCCTCAGGGAGATCTGT	0.602		NA											48	91					0	0	0	0
SLC26A10	65012	broad.mit.edu	37	12	58018675	58018675	+	Silent	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:58018675C>A	uc001spe.2	+	10	1565	c.1254C>A	c.(1252-1254)ATC>ATA	p.I418I	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	418	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					GGCTCTGCATCCTGAGCTATC	0.577		NA											78	165					7.68e-34	9e-34	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184678	130184678	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:130184678G>A	uc009zyl.1	-	2	973	c.645C>T	c.(643-645)TCC>TCT	p.S215S		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	215	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGGTCCACGGACTTCCTCC	0.692		NA											40	79					0	0	0	0
ZNF10	7556	broad.mit.edu	37	12	133732286	133732286	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:133732286T>G	uc009zzb.2	+	5	901	c.454T>G	c.(454-456)TTC>GTC	p.F152V	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.F152V	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	152				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GCAAGTGGCATTCACCCAAAA	0.413		NA											43	64					0	0	0	0
RIPK3	11035	broad.mit.edu	37	14	24808260	24808260	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:24808260C>T	uc001wpb.2	-	3	642	c.432G>A	c.(430-432)AAG>AAA	p.K144K	RIPK3_uc001wpa.2_5'UTR|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Silent_p.K144K	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	144	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CGTTGGATGGCTTGAGGTCCC	0.627		NA											30	34					0	0	0	0
MIA2	117153	broad.mit.edu	37	14	39716525	39716525	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:39716525C>T	uc001wux.2	+	4	941	c.747C>T	c.(745-747)AGC>AGT	p.S249S	MIA2_uc010amy.1_Silent_p.S180S	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	249						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TACAAGAAAGCTCATTTCGGA	0.403		NA											46	25					0	0	0	0
PTGER2	5732	broad.mit.edu	37	14	52781581	52781581	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:52781581G>A	uc001wzr.2	+	1	566	c.315G>A	c.(313-315)GAG>GAA	p.E105E		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	105	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGGCGCCCGAGAGCCGCGCGT	0.647		NA											26	63					0	0	0	0
C14orf169	79697	broad.mit.edu	37	14	73959252	73959252	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:73959252C>T	uc001xok.1	+	3	1610	c.1531C>T	c.(1531-1533)CCC>TCC	p.P511S	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	511					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		CGATTCTCTGCCCCCTGTTTT	0.562		NA											39	16					0	0	0	0
FBLN5	10516	broad.mit.edu	37	14	92357640	92357640	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:92357640C>T	uc001xzx.3	-	6	1017	c.544G>A	c.(544-546)GCG>ACG	p.A182T	FBLN5_uc010aud.2_Missense_Mutation_p.A187T|FBLN5_uc010aue.2_Missense_Mutation_p.A223T	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	182	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GGAACATTCGCACAGAGCTGC	0.473		NA											79	29					0	0	0	0
FMN1	342184	broad.mit.edu	37	15	33359987	33359987	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:33359987G>A	uc001zhf.3	-	1	99	c.99C>T	c.(97-99)TTC>TTT	p.F33F	FMN1_uc001zhg.2_Silent_p.F33F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		ATTTCATAGAGAACTTACTCA	0.428		NA											42	68					0	0	0	0
THBS1	7057	broad.mit.edu	37	15	39876366	39876366	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:39876366T>C	uc001zkh.2	+	5	1060	c.881T>C	c.(880-882)CTG>CCG	p.L294P		NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	294					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTGACCACGCTGCAGGACAGC	0.557		NA											19	42					0	0	0	0
MAPK6	5597	broad.mit.edu	37	15	52339091	52339091	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:52339091C>G	uc002abp.2	+	2	1228	c.434C>G	c.(433-435)TCT>TGT	p.S145C		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	145	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		TATATTCACTCTGCAAATGTA	0.468		NA											71	96					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2376444	2376444	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:2376444C>T	uc002cpy.1	-	4	736	c.24G>A	c.(22-24)GCG>GCA	p.A8A	ABCA3_uc010bsk.1_Silent_p.A8A|ABCA3_uc010bsl.1_Silent_p.A8A|ABCA3_uc002cpz.1_Silent_p.A8A	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	8					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGAGGAGGAGCGCCAGCTGCC	0.602		NA											15	37					0	0	0	0
TOX3	27324	broad.mit.edu	37	16	52497888	52497888	+	Silent	SNP	G	G	A	rs147213203	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:52497888G>A	uc002egw.2	-	3	537	c.366C>T	c.(364-366)CTC>CTT	p.L122L	TOX3_uc010vgt.1_Silent_p.L117L|TOX3_uc010vgu.1_Silent_p.L122L	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	122					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						CTTGTTCCACGAGATTTCTTG	0.433		NA											58	118					0	0	0	0
HYDIN	54768	broad.mit.edu	37	16	70913521	70913521	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:70913521C>G	uc002ezr.2	-	61	10479	c.10351G>C	c.(10351-10353)GAT>CAT	p.D3451H		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3452										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GGCAAGCCATCCAAGGTAGCC	0.577		NA											18	83					0	0	0	0
CBFA2T3	863	broad.mit.edu	37	16	88968004	88968004	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:88968004G>A	uc002fmm.1	-	2	398	c.212C>T	c.(211-213)ACG>ATG	p.T71M	CBFA2T3_uc002fml.1_Missense_Mutation_p.T10M|CBFA2T3_uc010cif.1_Missense_Mutation_p.T10M|CBFA2T3_uc002fmn.1_Missense_Mutation_p.T71M	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	71	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCGGGGCTGCGTCTTCACCTC	0.667		NA	T	RUNX1	AML								23	46					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577570	7577570	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:7577570C>T	uc002gim.2	-	7	905	c.711G>A	c.(709-711)ATG>ATA	p.M237I	TP53_uc002gig.1_Missense_Mutation_p.M237I|TP53_uc002gih.2_Missense_Mutation_p.M237I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M105I|TP53_uc010cng.1_Missense_Mutation_p.M105I|TP53_uc002gii.1_Missense_Mutation_p.M105I|TP53_uc010cnh.1_Missense_Mutation_p.M237I|TP53_uc010cni.1_Missense_Mutation_p.M237I|TP53_uc002gij.2_Missense_Mutation_p.M237I|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M144I|TP53_uc002gio.2_Missense_Mutation_p.M105I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	237	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(99)|p.M237K(8)|p.0?(7)|p.M237V(6)|p.M237fs*10(4)|p.M237R(3)|p.M237T(2)|p.M237L(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.M237_N239delMCN(1)|p.H233fs*6(1)|p.M144I(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.M237fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	21					0	0	0	0
MYO18A	399687	broad.mit.edu	37	17	27493807	27493807	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:27493807G>A	uc002hdt.1	-	2	310	c.152C>T	c.(151-153)TCC>TTC	p.S51F	MYO18A_uc010csa.1_Missense_Mutation_p.S51F|MYO18A_uc002hdu.1_Missense_Mutation_p.S51F	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	51					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACGCTTGGAGGAGCGGTTCAG	0.517		NA											11	16					0	0	0	0
HNF1B	6928	broad.mit.edu	37	17	36064935	36064935	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:36064935G>C	uc002hok.3	-	6	1549	c.1328C>G	c.(1327-1329)GCA>GGA	p.A443G	HNF1B_uc010wdi.1_Missense_Mutation_p.A417G	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	443					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TTGTGCAATTGCCATGACTCC	0.463		NA							Hereditary_Prostate_Cancer				56	141					0	0	0	0
KRT33B	3884	broad.mit.edu	37	17	39522833	39522833	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:39522833G>A	uc002hwl.2	-	3	522	c.477C>T	c.(475-477)ATC>ATT	p.I159I		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	159	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GCAGGCTGTTGATGTCGGACT	0.562		NA											40	82					0	0	0	0
PPY	5539	broad.mit.edu	37	17	42018893	42018893	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:42018893C>T	uc002iep.2	-	2	175	c.130G>A	c.(130-132)GAG>AAG	p.E44K		NM_002722	NP_002713	P01298	PAHO_HUMAN	pancreatic polypeptide preproprotein	44					digestion|protein secretion	extracellular region	hormone activity				0		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCCATCTGCTCTGGTGTGGCA	0.607		NA											44	107					0	0	0	0
SCN4A	6329	broad.mit.edu	37	17	62034533	62034533	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:62034533C>T	uc002jds.1	-	13	2442	c.2365G>A	c.(2365-2367)GGC>AGC	p.G789S		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	789	II.|Helical; Name=S6 of repeat II; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	ACAAGATTGCCGATGACCATG	0.582		NA											17	43					0	0	0	0
FBF1	85302	broad.mit.edu	37	17	73915956	73915956	+	Splice_Site	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:73915956C>T	uc002jqc.2	-	19	2161	c.1887_splice	c.e19-1	p.R629_splice	FBF1_uc002jqa.1_Splice_Site|FBF1_uc010wsp.1_Splice_Site_p.R620_splice|FBF1_uc002jqd.1_Splice_Site_p.R630_splice|FBF1_uc002jqb.2_Splice_Site|FBF1_uc010dgr.1_Splice_Site	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1												0						GATGCGGCTTCTGCCAACAGA	0.602		NA											37	57					0	0	0	0
AANAT	15	broad.mit.edu	37	17	74465350	74465350	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:74465350G>A	uc002jro.2	+	3	493	c.259G>A	c.(259-261)GAG>AAG	p.E87K	AANAT_uc010wte.1_RNA	NM_001088	NP_001079	Q16613	SNAT_HUMAN	arylalkylamine N-acetyltransferase	87	N-acetyltransferase.				circadian rhythm|melatonin biosynthetic process	cytosol	aralkylamine N-acetyltransferase activity				0						CTGGTTCGAGGAGGGCTGCCT	0.627		NA											113	232					0	0	0	0
SYNGR2	9144	broad.mit.edu	37	17	76167595	76167595	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:76167595C>T	uc002juu.1	+	3	369	c.342C>T	c.(340-342)CTC>CTT	p.L114L	SYNGR2_uc002jut.2_Silent_p.L114L|SYNGR2_uc002juv.1_Intron|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	114	MARVEL.|Helical; (Potential).					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			CCCCAGCTCTCTGGACCTTCC	0.637		NA											34	71					0	0	0	0
SPIRE1	56907	broad.mit.edu	37	18	12453101	12453101	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:12453101A>G	uc002kre.2	-	14	1860	c.1813T>C	c.(1813-1815)TTC>CTC	p.F605L	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.F471L|SPIRE1_uc010wzx.1_Missense_Mutation_p.F394L|SPIRE1_uc010wzy.1_Missense_Mutation_p.F591L	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	605						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						GACCAAGTGAAGAAGGAAAAC	0.328		NA											4	79					0	0	0	0
NETO1	81832	broad.mit.edu	37	18	70461640	70461640	+	Splice_Site	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:70461640C>G	uc002lkw.2	-	5	754	c.470_splice	c.e5-1	p.D157_splice	NETO1_uc002lkx.1_Splice_Site_p.D156_splice|NETO1_uc002lky.1_Splice_Site_p.D157_splice	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3						memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AAGTCAGGATCTTAAAAATTG	0.294		NA											82	61					0	0	0	0
FBXO15	201456	broad.mit.edu	37	18	71797839	71797839	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:71797839C>T	uc002lle.2	-	4	495	c.159G>A	c.(157-159)TGG>TGA	p.W53*	FBXO15_uc002llf.2_Nonsense_Mutation_p.W129*	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	53										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AATTAAATTTCCAATTTGATC	0.348		NA											4	40					0	0	0	0
TICAM1	148022	broad.mit.edu	37	19	4817884	4817884	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:4817884G>T	uc002mbi.2	-	2	757	c.506C>A	c.(505-507)TCG>TAG	p.S169*		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	169					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGGCAAAGCCGAGGATGGTGG	0.652		NA											7	176					0.00198382	0.00207322	1	0
KANK2	25959	broad.mit.edu	37	19	11283762	11283762	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:11283762G>A	uc010dxv.2	-	12	2664	c.2106C>T	c.(2104-2106)TAC>TAT	p.Y702Y	KANK2_uc002mqm.2_Silent_p.Y710Y|KANK2_uc002mqo.3_Silent_p.Y702Y|KANK2_uc002mqp.1_Silent_p.Y511Y	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	702	ANK 2.										0						TAATAGGGCTGTAGCCAGCAC	0.567		NA											77	110					0	0	0	0
MAST1	22983	broad.mit.edu	37	19	12976159	12976159	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:12976159C>T	uc002mvm.2	+	15	1796	c.1668C>T	c.(1666-1668)CCC>CCT	p.P556P		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	556	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						ACATCGCGCCCGAGGTCATCC	0.657		NA											64	76					0	0	0	0
ZNF253	56242	broad.mit.edu	37	19	20003119	20003119	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:20003119C>T	uc002noj.2	+	4	1155	c.1063C>T	c.(1063-1065)CTT>TTT	p.L355F	ZNF253_uc002nok.2_Missense_Mutation_p.L279F|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	355	C2H2-type 7.			Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCCTCACACCTTACTACACA	0.388		NA											41	45					0	0	0	0
ZNF714	148206	broad.mit.edu	37	19	21300358	21300358	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:21300358C>T	uc002npo.3	+	6	1251	c.891C>T	c.(889-891)TTC>TTT	p.F297F	ZNF714_uc002npl.2_Silent_p.F142F|ZNF714_uc010ecp.1_Silent_p.F248F|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	297	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTAACCGATTCTCATACCTTA	0.348		NA											3	17					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22170088	22170088	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:22170088C>T	uc002nqp.2	-	3	305	c.156G>A	c.(154-156)CTG>CTA	p.L52L	ZNF208_uc002nqo.1_Silent_p.L52L|ZNF208_uc002nqq.2_RNA	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAAAAATGATCAGGTCTGGCT	0.398		NA											29	69					0	0	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580552	40580552	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:40580552T>G	uc002omy.2	-	6	2022	c.1797A>C	c.(1795-1797)CAA>CAC	p.Q599H	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.Q599H|ZNF780A_uc010xvh.1_Missense_Mutation_p.Q600H	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	599	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTCGAATAAGTTGCATATGAA	0.403		NA											4	325					0	0	0	0
RELB	5971	broad.mit.edu	37	19	45528913	45528913	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:45528913C>T	uc002paj.1	+	8	930	c.804C>T	c.(802-804)ATC>ATT	p.I268I		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	268	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TGGTGAGGATCTGCTTCCAGG	0.567		NA											93	141					0	0	0	0
TULP2	7288	broad.mit.edu	37	19	49398650	49398650	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:49398650C>T	uc002pkz.2	-	5	473	c.322G>A	c.(322-324)GGC>AGC	p.G108S		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	108					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GTCGGGAGGCCGCGCTCGCCC	0.488		NA											80	126					0	0	0	0
CD33	945	broad.mit.edu	37	19	51742808	51742808	+	Silent	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:51742808T>A	uc002pwa.2	+	7	1000	c.960T>A	c.(958-960)ACT>ACA	p.T320T	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Silent_p.T193T|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	320	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	ATGGCCCCACTGAAACCTCAA	0.522		NA											31	50					0	0	0	0
ZNF610	162963	broad.mit.edu	37	19	52856995	52856995	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52856995G>C	uc002pyx.3	+	4	530	c.124G>C	c.(124-126)GAC>CAC	p.D42H	ZNF610_uc002pyy.3_Missense_Mutation_p.D42H|ZNF610_uc002pyz.3_Missense_Mutation_p.D42H|ZNF610_uc002pza.2_Missense_Mutation_p.D42H	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GAAATCCCTGGACCCTGGACA	0.493		NA											70	117					0	0	0	0
ZNF880	400713	broad.mit.edu	37	19	52887510	52887510	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52887510A>T	uc002pzc.2	+	4	726	c.677A>T	c.(676-678)AAC>ATC	p.N226I		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	226	C2H2-type 2.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AACAGTTCAAACCTTGTACAA	0.388		NA											7	22					0	0	0	0
MBOAT7	79143	broad.mit.edu	37	19	54692109	54692109	+	Silent	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:54692109G>C	uc002qdq.2	-	4	434	c.168C>G	c.(166-168)ACC>ACG	p.T56T	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.T38T|MBOAT7_uc002qdr.2_Silent_p.T56T|MBOAT7_uc002qds.2_Missense_Mutation_p.H26D|MBOAT7_uc010yen.1_Missense_Mutation_p.H26D|MBOAT7_uc002qdt.3_Silent_p.T56T|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	56	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCCCGAGGATGGTGACCAGAG	0.637		NA											70	108					0	0	0	0
BRSK1	84446	broad.mit.edu	37	19	55805389	55805389	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:55805389A>G	uc002qkg.2	+	5	740	c.463A>G	c.(463-465)AGA>GGA	p.R155G	BRSK1_uc002qkf.2_Missense_Mutation_p.R171G	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	155	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TCTCAGCCACAGAGACCTAAA	0.577		NA											110	229					0	0	0	0
DNAJC27	51277	broad.mit.edu	37	2	25186283	25186283	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:25186283G>T	uc002rft.1	-	3	282	c.231C>A	c.(229-231)TTC>TTA	p.F77L	DNAJC27_uc010ykn.1_Missense_Mutation_p.F6L|DNAJC27_uc002rfu.1_RNA|DNAJC27_uc010eyg.1_Missense_Mutation_p.F77L	NM_016544	NP_057628	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	77					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1						CCTCATAGAAGAAGGGATGTC	0.368		NA											22	50					1.56e-14	1.74e-14	1	0
SLC4A1AP	22950	broad.mit.edu	37	2	27887203	27887203	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:27887203C>G	uc002rlk.3	+	1	866	c.584C>G	c.(583-585)TCT>TGT	p.S195C	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	195	FHA.					cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGGAGGCTGTCTGGCTGCGAC	0.632		NA											32	56					0	0	0	0
GPR75	10936	broad.mit.edu	37	2	54080671	54080671	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:54080671C>T	uc002rxo.3	-	2	1494	c.1223G>A	c.(1222-1224)CGA>CAA	p.R408Q	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	408	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCCATGGCTCGAAGTCGAGT	0.448		NA											94	183					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56419779	56419779	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:56419779G>A	uc002rzn.2	+	2	946	c.444G>A	c.(442-444)CTG>CTA	p.L148L		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	148	Potential.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGCAGAAGCTGAAAGACCTGG	0.572		NA											39	56					0	0	0	0
ACTR2	10097	broad.mit.edu	37	2	65473816	65473816	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:65473816A>T	uc002sdq.2	+	3	533	c.318A>T	c.(316-318)AAA>AAT	p.K106N	ACTR2_uc010yqf.1_Missense_Mutation_p.K51N|ACTR2_uc002sdp.2_Missense_Mutation_p.K111N|ACTR2_uc010yqg.1_Missense_Mutation_p.K54N	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	106					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0						GAAATTGTAAAATCTTACTCA	0.368		NA											72	154					0	0	0	0
APLF	200558	broad.mit.edu	37	2	68765290	68765290	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:68765290C>T	uc002sep.2	+	7	1264	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.S340L|APLF_uc002ser.1_Missense_Mutation_p.S95L	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	364					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GCAACTGATTCAGTTCTACAA	0.443		NA											64	88					0	0	0	0
EXOC6B	23233	broad.mit.edu	37	2	72945308	72945308	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:72945308G>A	uc010fep.2	-	6	731	c.593C>T	c.(592-594)TCT>TTT	p.S198F	EXOC6B_uc002sij.2_Missense_Mutation_p.S198F	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	198					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						ATCGGACATAGAAACATCTTT	0.438		NA											56	104					0	0	0	0
YSK4	80122	broad.mit.edu	37	2	135745305	135745305	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:135745305G>A	uc002tue.1	-	7	1168	c.1137C>T	c.(1135-1137)AAC>AAT	p.N379N	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.N266N|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Silent_p.N107N|YSK4_uc002tui.3_Silent_p.N396N	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	379							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTGTTCATAGTTTTTGGCTA	0.378		NA											56	99					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141072662	141072662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:141072662G>T	uc002tvj.1	-	83	13619	c.12647C>A	c.(12646-12648)TCA>TAA	p.S4216*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4216	Extracellular (Potential).|EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAACTTACATGAATCATCTGT	0.303		NA								TSP Lung(27;0.18)			27	62					3.29e-13	3.64e-13	1	0
CERKL	375298	broad.mit.edu	37	2	182468677	182468677	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:182468677A>T	uc002unx.2	-	2	469	c.368T>A	c.(367-369)TTC>TAC	p.F123Y	CERKL_uc002uny.2_Missense_Mutation_p.F123Y|CERKL_uc010zfm.1_Missense_Mutation_p.F123Y|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Missense_Mutation_p.F123Y|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Missense_Mutation_p.F123Y|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_5'UTR|CERKL_uc002uoe.2_Missense_Mutation_p.F123Y	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	123					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAAGCAGATGAAGAGTGTGAT	0.333		NA											11	60					0	0	0	0
FAM171B	165215	broad.mit.edu	37	2	187626381	187626381	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:187626381C>T	uc002ups.2	+	8	1424	c.1312C>T	c.(1312-1314)CAG>TAG	p.Q438*	FAM171B_uc002upr.1_Intron|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	438	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						ATATAGTCCTCAGAAAAAGGA	0.348		NA											41	91					0	0	0	0
MARS2	92935	broad.mit.edu	37	2	198570720	198570720	+	Silent	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:198570720C>G	uc002uuq.2	+	1	634	c.591C>G	c.(589-591)CTC>CTG	p.L197L	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	197					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	CTGTATCTCTCGAGAGCGGGC	0.587		NA											57	119					0	0	0	0
CHPF	79586	broad.mit.edu	37	2	220404983	220404983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:220404983G>A	uc002vmc.3	-	4	1677	c.1450C>T	c.(1450-1452)CGA>TGA	p.R484*	CHPF_uc010zlh.1_Nonsense_Mutation_p.R322*	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	484	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCTGCACTCGGCGAGTGAGG	0.667		NA											14	32					0	0	0	0
CAPN10	11132	broad.mit.edu	37	2	241535795	241535795	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:241535795C>T	uc002vzk.1	+	8	1522	c.1338C>T	c.(1336-1338)ACC>ACT	p.T446T	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.T318T|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	446	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TGGCTGGCACCGCGTGCCATG	0.667		NA											4	193					0	0	0	0
TRIB3	57761	broad.mit.edu	37	20	377164	377164	+	Silent	SNP	C	C	A	rs139447354		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:377164C>A	uc002wdm.2	+	4	1413	c.907C>A	c.(907-909)CGG>AGG	p.R303R	TRIB3_uc002wdn.2_Silent_p.R330R	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	303	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCAGCTGAACGGCTCACAGC	0.687		NA											69	120					5.26e-25	6.03e-25	1	0
SNRPB	6628	broad.mit.edu	37	20	2443871	2443871	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:2443871C>T	uc002wfz.1	-	5	586	c.423G>A	c.(421-423)GTG>GTA	p.V141V	SNRPB_uc002wga.1_Silent_p.V141V|SNRPB_uc010zpv.1_Silent_p.V62V|SNRPB_uc002wgb.2_Silent_p.V141V|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	141					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						GTGGGGTCATCACCTAAGAGG	0.552		NA											8	68					0	0	0	0
C20orf194	25943	broad.mit.edu	37	20	3297377	3297377	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:3297377G>A	uc002wii.2	-	18	1583	c.1532C>T	c.(1531-1533)TCC>TTC	p.S511F	C20orf194_uc002wij.3_Missense_Mutation_p.S250F|C20orf194_uc002wik.2_Missense_Mutation_p.S185F	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	511											0						AACCAGCCAGGAGCAGAATCT	0.527		NA											21	42					0	0	0	0
UQCC	55245	broad.mit.edu	37	20	33999835	33999835	+	Splice_Site	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:33999835C>T	uc002xcd.2	-	1	1	c.-66_splice	c.e1-1		UQCC_uc010zuz.1_Splice_Site|UQCC_uc010zva.1_Splice_Site|UQCC_uc002xce.2_Splice_Site|UQCC_uc002xcg.2_Splice_Site|UQCC_uc010gfb.2_Splice_Site|UQCC_uc010zvb.1_Splice_Site|UQCC_uc002xcf.2_Splice_Site|GDF5_uc010gfc.1_Intron|UQCC_uc010gfd.1_Splice_Site	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform							cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTCCTTTTGCCGGCGAAAGA	0.597		NA											3	65					0	0	0	0
ACTR5	79913	broad.mit.edu	37	20	37400305	37400305	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:37400305A>T	uc002xjd.2	+	9	1695	c.1670A>T	c.(1669-1671)TAT>TTT	p.Y557F		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	557					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				AGGAAAGAGTATGAAGAAAAG	0.547		NA											59	84					0	0	0	0
CD40	958	broad.mit.edu	37	20	44756820	44756820	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:44756820C>G	uc002xrg.1	+	7	680	c.603C>G	c.(601-603)ATC>ATG	p.I201M	CD40_uc002xrh.1_Missense_Mutation_p.L181V|CD40_uc002xri.1_Missense_Mutation_p.L215V|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	201	Helical; (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCCCATCATCTTCGGGATCC	0.567		NA							Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	144					0	0	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19651350	19651350	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:19651350C>T	uc002ykw.2	-	23	2726	c.2695G>A	c.(2695-2697)GAA>AAA	p.E899K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	899	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TGATTTTCTTCCGGTAAACAA	0.323		NA											32	62					0	0	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338490	28338490	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:28338490A>C	uc002ymg.2	-	1	950	c.221T>G	c.(220-222)GTG>GGG	p.V74G		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	74					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GATGTTCTGCACCAGCCCCTT	0.726		NA											9	101					0	0	0	0
ITSN1	6453	broad.mit.edu	37	21	35166729	35166729	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:35166729C>G	uc002yta.1	+	17	2177	c.1909C>G	c.(1909-1911)CGA>GGA	p.R637G	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.R637G|ITSN1_uc010gmg.2_Missense_Mutation_p.R600G|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.R637G|ITSN1_uc010gmi.2_Missense_Mutation_p.R600G|ITSN1_uc010gmj.2_Missense_Mutation_p.R521G|ITSN1_uc002ysy.2_Missense_Mutation_p.R637G|ITSN1_uc002ysx.2_Missense_Mutation_p.R600G|ITSN1_uc002ytb.1_Missense_Mutation_p.R637G|ITSN1_uc002ytc.1_Missense_Mutation_p.R637G|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.R600G|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.R637G|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.R571G	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	637	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGAACAAGAACGAAAGATCAT	0.373		NA											48	84					0	0	0	0
LCA5L	150082	broad.mit.edu	37	21	40778524	40778524	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:40778524C>T	uc002yxu.2	-	10	1610	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	LCA5L_uc002yxv.2_Missense_Mutation_p.E433K	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	433	Potential.										0		Prostate(19;1.2e-06)				AAATGTTTCTCTTCCCCTGAT	0.333		NA											59	132					0	0	0	0
PCNT	5116	broad.mit.edu	37	21	47851584	47851584	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47851584G>T	uc002zji.3	+	38	8313	c.8206G>T	c.(8206-8208)GAG>TAG	p.E2736*	PCNT_uc002zjj.2_Nonsense_Mutation_p.E2618*	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2736	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCTGGCTCAGGAGCGGAGCCA	0.637		NA											18	53					1.56e-12	1.72e-12	1	0
PCNT	5116	broad.mit.edu	37	21	47852115	47852115	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47852115G>C	uc002zji.3	+	38	8844	c.8737G>C	c.(8737-8739)GAC>CAC	p.D2913H	PCNT_uc002zjj.2_Intron	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2913	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTGGCAGAGAGACAAGGAGAA	0.602		NA											6	7					0	0	0	0
ISX	91464	broad.mit.edu	37	22	35481475	35481475	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:35481475G>A	uc003anj.2	+	4	1478	c.527G>A	c.(526-528)CGC>CAC	p.R176H	ISX_uc011amg.1_Missense_Mutation_p.R164H	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						ACTGCTCTGCGCAGGCTGGCT	0.617		NA											5	261					0	0	0	0
TNRC6B	23112	broad.mit.edu	37	22	40697290	40697290	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:40697290G>A	uc011aor.1	+	15	4284	c.4073G>A	c.(4072-4074)GGG>GAG	p.G1358E	TNRC6B_uc003aym.2_Missense_Mutation_p.G554E|TNRC6B_uc003ayn.3_Missense_Mutation_p.G1248E|TNRC6B_uc003ayo.2_Missense_Mutation_p.G1105E	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1358					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TTGAATGTGGGGCTCCCAGAC	0.423		NA											12	17					0	0	0	0
TCF20	6942	broad.mit.edu	37	22	42610152	42610152	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:42610152G>A	uc003bcj.1	-	1	1294	c.1160C>T	c.(1159-1161)TCT>TTT	p.S387F	TCF20_uc003bck.1_Missense_Mutation_p.S387F|TCF20_uc003bnt.2_Missense_Mutation_p.S387F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CATGAGAGGAGATGGGGTAGA	0.512		NA											62	147					0	0	0	0
GRM7	2917	broad.mit.edu	37	3	7188164	7188164	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:7188164C>T	uc003bqm.2	+	2	819	c.545C>T	c.(544-546)ACG>ATG	p.T182M	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.T182M|GRM7_uc003bql.2_Missense_Mutation_p.T182M	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	182	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TATGCATCAACGGCACCCGAG	0.502		NA											64	56					0	0	0	0
RAB5A	5868	broad.mit.edu	37	3	20025262	20025262	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:20025262G>A	uc003cbn.2	+	6	1130	c.595G>A	c.(595-597)GTA>ATA	p.V199I	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.V185I|C3orf48_uc010hez.2_Intron	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	199					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						AGGAAGAGGAGTAGACCTTAC	0.368		NA											9	16					0	0	0	0
UBP1	7342	broad.mit.edu	37	3	33481236	33481236	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:33481236G>A	uc003cfq.3	-	1	635	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y	UBP1_uc003cfr.3_Silent_p.Y35Y|UBP1_uc010hga.2_Silent_p.Y35Y	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	35					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						ACCTCATGCTGTAAGCGCCGG	0.667		NA											33	27					0	0	0	0
SCN11A	11280	broad.mit.edu	37	3	38888755	38888755	+	Silent	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:38888755C>A	uc011ays.1	-	26	5005	c.4806G>T	c.(4804-4806)GTG>GTT	p.V1602V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1602	IV.|Helical; Name=S6 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTCTAAAATCACAGCAATGT	0.413		NA											4	148					0.00024832	0.000262325	1	0
ULK4	54986	broad.mit.edu	37	3	41877374	41877374	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:41877374G>C	uc003ckv.3	-	18	1947	c.1746C>G	c.(1744-1746)ATC>ATG	p.I582M	ULK4_uc003ckw.2_Missense_Mutation_p.I582M	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	582							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTACAAGATAGATCAGCTCCC	0.393		NA											4	166					0	0	0	0
PDE12	201626	broad.mit.edu	37	3	57543358	57543358	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:57543358C>G	uc003diw.3	+	1	1378	c.1252C>G	c.(1252-1254)CTA>GTA	p.L418V	PDE12_uc003div.2_Missense_Mutation_p.L418V	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	418							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GCTGGAGAAACTAGTTTTGTA	0.468		NA											50	41					0	0	0	0
STXBP5L	9515	broad.mit.edu	37	3	121100262	121100262	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:121100262A>G	uc003eec.3	+	23	2682	c.2542A>G	c.(2542-2544)ACC>GCC	p.T848A	STXBP5L_uc011bji.1_Missense_Mutation_p.T824A	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	848	WD 11.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAATGACTCTACCATCTCTCC	0.408		NA											108	263					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	151148153	151148153	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:151148153C>G	uc003eyp.2	+	42	6408	c.6370C>G	c.(6370-6372)CAG>GAG	p.Q2124E	MED12L_uc011bnz.1_Missense_Mutation_p.Q1788E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2124	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCGGCAGCTCCAGAAGCAGCT	0.537		NA											47	150					0	0	0	0
P2RY1	5028	broad.mit.edu	37	3	152554038	152554038	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554038C>T	uc003ezq.2	+	1	1303	c.467C>T	c.(466-468)CCC>CTC	p.P156L		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	156	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			GTGGTGTACCCCCTCAAGTCC	0.527		NA											31	135					0	0	0	0
P2RY1	5028	broad.mit.edu	37	3	152554042	152554042	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554042C>T	uc003ezq.2	+	1	1307	c.471C>T	c.(469-471)CTC>CTT	p.L157L		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	157	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGTACCCCCTCAAGTCCCTGG	0.532		NA											31	138					0	0	0	0
P2RY1	5028	broad.mit.edu	37	3	152554482	152554482	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554482C>T	uc003ezq.2	+	1	1747	c.911C>T	c.(910-912)GCC>GTC	p.A304V		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	304	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AGGGTTTATGCCACGTATCAG	0.478		NA											5	264					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	156979086	156979086	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:156979086C>A	uc003fbj.1	-	14	2656	c.2339G>T	c.(2338-2340)AGG>ATG	p.R780M	VEPH1_uc003fbk.1_Missense_Mutation_p.R780M|VEPH1_uc010hvu.1_Missense_Mutation_p.R735M	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	780	PH.					plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			AGAGCGGTCCCTGCGTTTCTT	0.483		NA											4	226					0.000602214	0.000633431	1	0
SERPINI2	5276	broad.mit.edu	37	3	167167167	167167167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:167167167G>A	uc003fer.1	-	6	1046	c.988C>T	c.(988-990)CAA>TAA	p.Q330*	SERPINI2_uc003fes.1_Nonsense_Mutation_p.Q340*|SERPINI2_uc003fet.1_Nonsense_Mutation_p.Q330*	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	330					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TGCGTCACTTGGGAAACATAC	0.338		NA											3	89					0	0	0	0
KLHL6	89857	broad.mit.edu	37	3	183225976	183225976	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:183225976G>A	uc003flr.2	-	3	838	c.780C>T	c.(778-780)AAC>AAT	p.N260N	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.N258N	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	260	BACK.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTAAGCGCACGTTCTCGAGGA	0.522		NA											89	217					0	0	0	0
BOD1L	259282	broad.mit.edu	37	4	13602595	13602595	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:13602595C>G	uc003gmz.1	-	10	6046	c.5929G>C	c.(5929-5931)GGT>CGT	p.G1977R	BOD1L_uc010idr.1_Missense_Mutation_p.G1314R	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1977							DNA binding			ovary(5)|breast(1)	6						GTCATAGGACCCTCACAACCT	0.483		NA											44	51					0	0	0	0
REST	5978	broad.mit.edu	37	4	57785989	57785989	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:57785989C>G	uc003hch.2	+	3	1282	c.935C>G	c.(934-936)TCA>TGA	p.S312*	REST_uc003hci.2_Nonsense_Mutation_p.S312*|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	312	C2H2-type 5.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					TGTCCTTACTCAAGTTCTCAG	0.328		NA											40	44					0	0	0	0
CENPE	1062	broad.mit.edu	37	4	104068527	104068527	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:104068527C>T	uc003hxb.1	-	29	4210	c.4120G>A	c.(4120-4122)GAA>AAA	p.E1374K	CENPE_uc003hxc.1_Missense_Mutation_p.E1349K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1374	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GCCAAAGTTTCTCTAATATGT	0.323		NA											7	100					0	0	0	0
IRX4	50805	broad.mit.edu	37	5	1879734	1879734	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:1879734G>T	uc003jcz.2	-	4	739	c.620C>A	c.(619-621)ACG>AAG	p.T207K	IRX4_uc011cmf.1_Missense_Mutation_p.T68K	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	207					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		CGGCGGCCACGTCATCTTGTT	0.478		NA											35	73					1.07e-15	1.2e-15	1	0
ADCY2	108	broad.mit.edu	37	5	7802384	7802384	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:7802384G>A	uc003jdz.1	+	21	2749	c.2682G>A	c.(2680-2682)CCG>CCA	p.P894P	ADCY2_uc011cmo.1_Silent_p.P714P|ADCY2_uc010itm.1_Silent_p.P90P	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	894	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CCTCCATTCCGGATTTCAAAG	0.473		NA											32	53					0	0	0	0
FBXL7	23194	broad.mit.edu	37	5	15928296	15928296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:15928296G>A	uc003jfn.1	+	3	906	c.425G>A	c.(424-426)CGC>CAC	p.R142H		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	142	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CGAGTGTGCCGCCGCTGGTAC	0.672		NA											9	15					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24509693	24509693	+	Missense_Mutation	SNP	G	G	C	rs1395027		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:24509693G>C	uc003jgr.1	-	7	1570	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	413	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCTGGAAATAGAATCTGGGTC	0.294		NA								HNSCC(23;0.051)			43	75					0	0	0	0
MRPS30	10884	broad.mit.edu	37	5	44813211	44813211	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:44813211C>T	uc003joh.2	+	4	895	c.857C>T	c.(856-858)TCA>TTA	p.S286L		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	286					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TCTTCAGGCTCAAAAACTGCA	0.373		NA											21	128					0	0	0	0
PDE4D	5144	broad.mit.edu	37	5	59284492	59284492	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:59284492C>T	uc003jsb.2	-	3	308	c.95G>A	c.(94-96)GGA>GAA	p.G32E	PDE4D_uc010iwj.1_Missense_Mutation_p.G32E|PDE4D_uc003jse.1_Missense_Mutation_p.G44E	NM_006203	NP_006194	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 2	Error:Variant_position_missing_in_Q08499_after_alignment					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GGGTTCCATTCCGCGGAAAGG	0.428		NA											56	126					0	0	0	0
SV2C	22987	broad.mit.edu	37	5	75621244	75621244	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:75621244A>C	uc003kei.1	+	13	2190	c.2056A>C	c.(2056-2058)AAC>CAC	p.N686H		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	686	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CGTCCTGGGAAACTTAATATT	0.522		NA											82	138					0	0	0	0
KCNN2	3781	broad.mit.edu	37	5	113831873	113831873	+	Silent	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:113831873T>C	uc003kqo.2	+	8	2191	c.1734T>C	c.(1732-1734)AGT>AGC	p.S578S	KCNN2_uc003kqp.2_Silent_p.S230S|KCNN2_uc010jcg.2_RNA|uc003kqr.1_RNA	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	578						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CATCAGAGAGTAGCTAGAAGA	0.458		NA											3	192					0	0	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630361	131630361	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630361C>G	uc003kwq.2	+	1	217	c.52C>G	c.(52-54)CAG>GAG	p.Q18E	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	18	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GGGGCCCTTCCAGCGCCTCAT	0.617		NA											26	58					0	0	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630460	131630460	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630460C>G	uc003kwq.2	+	1	316	c.151C>G	c.(151-153)CGA>GGA	p.R51G	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	51	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCACCGCTGTCGAGTGCCGGA	0.672		NA											24	47					0	0	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481978	140481978	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:140481978C>T	uc003lio.2	+	1	1745	c.1745C>T	c.(1744-1746)CCG>CTG	p.P582L	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	582	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCTGAGCCGGGCTACCTG	0.701		NA											63	115					0	0	0	0
C6orf146	222826	broad.mit.edu	37	6	4069240	4069240	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:4069240G>C	uc003mvx.2	-	7	1557	c.1217C>G	c.(1216-1218)TCT>TGT	p.S406C	C6orf146_uc010jnq.1_Intron|C6orf146_uc003mvy.2_Missense_Mutation_p.S343C	NM_173563	NP_775834	Q8IXS0	CF146_HUMAN	hypothetical protein LOC222826	406										ovary(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				ACTTAAAATAGAACTTTTGGG	0.368		NA											74	50					0	0	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570125	22570125	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:22570125G>A	uc003nds.2	+	1	448	c.321G>A	c.(319-321)CCG>CCA	p.P107P		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	107											0	Ovarian(93;0.163)					GGCCTTGGCCGGAGCCCGAGG	0.687		NA											2	3					0	0	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33402927	33402927	+	Splice_Site	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:33402927A>T	uc011dri.1	+	6	705	c.510_splice	c.e6-2	p.R170_splice	SYNGAP1_uc003oeo.1_Splice_Site_p.R155_splice|SYNGAP1_uc010juy.2_Splice_Site_p.R155_splice|SYNGAP1_uc010juz.2_5'Flank	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CCTGCCTGCCAGGGCCCGGCT	0.403		NA											4	158					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82582957	82582957	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:82582957G>A	uc003uhx.2	-	5	7601	c.7312C>T	c.(7312-7314)CTT>TTT	p.L2438F	PCLO_uc003uhv.2_Missense_Mutation_p.L2438F|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2369	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTTTAGGAAGAATAGTTGGT	0.249		NA											13	11					0	0	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99757768	99757768	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:99757768T>C	uc003utt.2	-	3	2261	c.1244A>G	c.(1243-1245)GAC>GGC	p.D415G	C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.D415G|GAL3ST4_uc010lgq.2_Missense_Mutation_p.D353G	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	415	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTATTTGGGGTCAGAAGCCTC	0.587		NA											75	343					0	0	0	0
NAPEPLD	222236	broad.mit.edu	37	7	102743965	102743965	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102743965G>C	uc003vbc.2	-	5	1421	c.1093C>G	c.(1093-1095)CTA>GTA	p.L365V	NAPEPLD_uc003vbd.2_Missense_Mutation_p.L365V|NAPEPLD_uc011klj.1_Missense_Mutation_p.L438V|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	365					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						TATCTCTCTAGAGCTTCATTC	0.333		NA											51	185					0	0	0	0
DNAJC2	27000	broad.mit.edu	37	7	102953456	102953456	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102953456A>G	uc003vbo.2	-	16	1980	c.1729T>C	c.(1729-1731)TGG>CGG	p.W577R	PMPCB_uc003vbl.2_3'UTR|PMPCB_uc003vbm.2_3'UTR|PMPCB_uc010liv.2_3'UTR|PMPCB_uc010liw.2_3'UTR|PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Missense_Mutation_p.W202R|DNAJC2_uc010lix.2_Missense_Mutation_p.W524R|DNAJC2_uc003vbp.2_Missense_Mutation_p.W202R	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	577	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						ATTTTTTCCCATCTTTCAGGT	0.398		NA											141	667					0	0	0	0
PSMC2	5701	broad.mit.edu	37	7	102988177	102988178	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102988177_102988178GC>TT	uc003vbs.2	+	1	89_90	c.19_20GC>TT	c.(19-21)GCC>TTC	p.A7F	DNAJC2_uc003vbo.2_5'Flank|DNAJC2_uc010lix.2_5'Flank|DNAJC2_uc003vbp.2_5'Flank|DNAJC2_uc003vbq.1_5'Flank|DNAJC2_uc003vbr.1_5'Flank|PSMC2_uc011kln.1_Missense_Mutation_p.A7F|PSMC2_uc011klo.1_5'UTR	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	7					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTACCTCGGTGCCGATCAGCGG	0.579		NA											35	270					0	0	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748457	8748457	+	Silent	SNP	G	G	A	rs150651778		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748457G>A	uc003wsj.1	-	1	2675	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	704											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCAGGTAGGAGAGGGCACTCT	0.627		NA											26	40					0	0	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748738	8748738	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748738G>C	uc003wsj.1	-	1	2394	c.1831C>G	c.(1831-1833)CAA>GAA	p.Q611E		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	611	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AGCAGGTATTGAAAATGGGCC	0.627		NA											49	97					0	0	0	0
SCARA5	286133	broad.mit.edu	37	8	27737157	27737157	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:27737157C>T	uc003xgj.2	-	8	1720	c.1280G>A	c.(1279-1281)GGA>GAA	p.G427E	SCARA5_uc010luz.2_Missense_Mutation_p.G202E	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	427	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACCACGTCTCCGTCCTTCTT	0.637		NA											74	151					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113267588	113267588	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:113267588A>G	uc003ynu.2	-	62	10090	c.9931T>C	c.(9931-9933)TCA>CCA	p.S3311P	CSMD3_uc003yns.2_Missense_Mutation_p.S2513P|CSMD3_uc003ynt.2_Missense_Mutation_p.S3271P|CSMD3_uc011lhx.1_Missense_Mutation_p.S3142P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3311	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAAACCTCTGACTGGTATATA	0.413		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	88					0	0	0	0
FAM83H	286077	broad.mit.edu	37	8	144812752	144812752	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:144812752T>C	uc003yzk.2	-	2	70	c.1A>G	c.(1-3)ATG>GTG	p.M1V	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGACGGGCCATGTTGGGGCCA	0.657		NA											12	25					0	0	0	0
SMARCA2	6595	broad.mit.edu	37	9	2097460	2097460	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:2097460C>A	uc003zhc.2	+	21	3166	c.3067C>A	c.(3067-3069)CAG>AAG	p.Q1023K	SMARCA2_uc003zhd.2_Missense_Mutation_p.Q1023K|SMARCA2_uc010mha.2_Missense_Mutation_p.Q956K	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1023					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATATATGTTTCAGCACATTGA	0.353		NA											64	50					2.1e-13	2.33e-13	1	0
BAT2L1	84726	broad.mit.edu	37	9	134350562	134350562	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:134350562G>A	uc004can.3	+	15	3101	c.3046G>A	c.(3046-3048)GAG>AAG	p.E1016K	BAT2L1_uc010mzj.1_Missense_Mutation_p.E599K|BAT2L1_uc004cao.3_Missense_Mutation_p.E374K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1016							protein binding				0						TTTTGGCCGCGAGGCCACCAA	0.562		NA											20	10					0	0	0	0
UBAC1	10422	broad.mit.edu	37	9	138825301	138825301	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:138825301G>A	uc004cgt.2	-	10	1381	c.1163C>T	c.(1162-1164)ACG>ATG	p.T388M	UBAC1_uc004cgs.1_Intron|UBAC1_uc004cgu.2_RNA	NM_016172	NP_057256	Q9BSL1	UBAC1_HUMAN	ubiquitin associated domain containing 1	388	STI1.					Golgi apparatus|plasma membrane	protein binding			skin(2)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.1e-06)|Epithelial(140;7.79e-06)		GACAGGCCCCGTTTCTGGATC	0.562		NA											86	62					0	0	0	0
EHMT1	79813	broad.mit.edu	37	9	140708936	140708936	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:140708936C>T	uc011mfc.1	+	22	3271	c.3234C>T	c.(3232-3234)CTC>CTT	p.L1078L	EHMT1_uc004coe.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1078	Pre-SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCGGCCAGCTCAGCATGCGCT	0.642		NA											48	32					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821254	5821254	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:5821254G>T	uc010ndh.2	-	5	1966	c.1465C>A	c.(1465-1467)CAT>AAT	p.H489N	NLGN4X_uc004crp.2_Missense_Mutation_p.H509N|NLGN4X_uc004crq.2_Missense_Mutation_p.H489N|NLGN4X_uc010ndi.2_Missense_Mutation_p.H526N|NLGN4X_uc004crr.2_Missense_Mutation_p.H489N|NLGN4X_uc010ndj.2_Missense_Mutation_p.H489N	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	489	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCATCACCATGGGCCGAATCT	0.572		NA											51	16					2.14e-21	2.43e-21	1	0
FAM47C	442444	broad.mit.edu	37	X	37028587	37028587	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:37028587C>T	uc004ddl.1	+	1	2118	c.2104C>T	c.(2104-2106)CTC>TTC	p.L702F		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	702										ovary(3)	3						AGTGTCCCGTCTCCACCCAGA	0.642		NA											61	33					0	0	0	0
DUSP21	63904	broad.mit.edu	37	X	44703874	44703874	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:44703874G>T	uc004dgd.2	+	1	626	c.496G>T	c.(496-498)GTG>TTG	p.V166L		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	166						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TAACAACACCGTGCGCATGAT	0.507		NA											37	19					7.53e-24	8.59e-24	1	0
TBX22	50945	broad.mit.edu	37	X	79281105	79281105	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:79281105C>T	uc010nmg.1	+	5	596	c.462C>T	c.(460-462)TAC>TAT	p.Y154Y	TBX22_uc004edi.1_Silent_p.Y34Y|TBX22_uc004edj.1_Silent_p.Y154Y	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	154	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TTTTCAGGTACGTCTATCACA	0.502		NA											25	23					0	0	0	0
PABPC5	140886	broad.mit.edu	37	X	90690655	90690656	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:90690655_90690656CC>AA	uc004efg.2	+	2	519_520	c.79_80CC>AA	c.(79-81)CCA>AAA	p.P27K	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	27	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TGACTTGGACCCAGATGTCACC	0.594		NA											21	7					0	0	0	0
CNGA2	1260	broad.mit.edu	37	X	150911736	150911736	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:150911736C>T	uc004fey.1	+	7	985	c.761C>T	c.(760-762)GCC>GTC	p.A254V		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	254	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCACTTTGCCCGCATGTTT	0.522		NA											4	126					0	0	0	0
RPL10	6134	broad.mit.edu	37	X	153628938	153628938	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:153628938G>A	uc004fkm.2	+	6	651	c.463G>A	c.(463-465)GCC>ACC	p.A155T	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Intron|RPL10_uc004fkn.1_Missense_Mutation_p.A155T|RPL10_uc004fkp.1_3'UTR|RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Missense_Mutation_p.A80T	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	155					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGCGCAGGGCCAAGTTCAA	0.582		NA											4	114					0	0	0	0
SLC16A12	387700	broad.mit.edu	37	10	91203593	91203605	+	Frame_Shift_Del	DEL	TCCACAAAAAAAA	TCCACAAAAAAAA	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:91203593_91203605delTCCACAAAAAAAA	uc001kgm.2	-	4	513_525	c.122_134delTTTTTTTTGTGGA	c.(121-135)ATTTTTTTTGTGGAGfs	p.I41fs		NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	41_45	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						TGTCTGGAACTCCACAAAAAAAATTGAGATACA	0.371		NA											12	73	---	---	---	---	NA	NA	NA	NA
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:35940788_35940790delCTG	uc002nzg.2	+	2	252_254	c.172_174delCTG	c.(172-174)CTGdel	p.L62del	FFAR2_uc010eea.2_In_Frame_Del_p.L62del	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	62	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645		NA											8	90	---	---	---	---	NA	NA	NA	NA
SIGLEC8	27181	broad.mit.edu	37	19	51961617	51961619	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:51961617_51961619delGCA	uc002pwt.2	-	1	90_92	c.23_25delTGC	c.(22-27)CTGCCC>CCC	p.L8del	SIGLEC8_uc010yda.1_In_Frame_Del_p.L8del|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_In_Frame_Del_p.L8del	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	8					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAGagcaggggcagcagcagcag	0.493		NA											7	140	---	---	---	---	NA	NA	NA	NA
