Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NPHP4	261734	broad.mit.edu	37	1	6038470	6038470	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:6038470C>T	uc001alq.1	-	3	405	c.139G>A	c.(139-141)GTG>ATG	p.V47M	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_Intron	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	47					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTCCAGCACGCCCTAGGAG	0.557		NA											3	16					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16475542	16475542	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:16475542A>C	uc001aya.1	-	3	291	c.154T>G	c.(154-156)TGG>GGG	p.W52G	EPHA2_uc010oca.1_Missense_Mutation_p.W52G	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	52	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ATCAGGTCCCACTGTGGGGGG	0.557		NA											11	58					0	0	0	0
ELTD1	64123	broad.mit.edu	37	1	79383352	79383352	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:79383352C>A	uc001diq.3	-	12	1872	c.1716G>T	c.(1714-1716)TGG>TGT	p.W572C		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	572	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTATAAAACTCCAAATAAAGT	0.279		NA											10	46					3.86e-05	4.21e-05	1	0
STXBP3	6814	broad.mit.edu	37	1	109295688	109295688	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:109295688A>T	uc001dvy.2	+	3	178	c.103A>T	c.(103-105)ATG>TTG	p.M35L	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	35	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTTAAGATAATGCTTTTAGA	0.289		NA											36	110					0	0	0	0
NME7	29922	broad.mit.edu	37	1	169200035	169200035	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:169200035G>C	uc001gfu.2	-	10	1149	c.911C>G	c.(910-912)TCT>TGT	p.S304C	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.S268C	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	304					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					ACAAGGGCCAGAATACATTTC	0.259		NA											29	54					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196205130	196205130	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:196205130C>T	uc001gtd.1	-	27	3342	c.3282G>A	c.(3280-3282)GAG>GAA	p.E1094E	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.E1027E|KCNT2_uc001gtf.1_Silent_p.E1070E|KCNT2_uc001gtg.1_RNA	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1094	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CATCATTCAGCTCTATTCTGG	0.313		NA											89	298					0	0	0	0
MARK1	4139	broad.mit.edu	37	1	220825399	220825399	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:220825399G>T	uc001hmn.3	+	15	2240	c.1643G>T	c.(1642-1644)CGA>CTA	p.R548L	MARK1_uc009xdw.2_Missense_Mutation_p.R548L|MARK1_uc010pun.1_Missense_Mutation_p.R548L|MARK1_uc001hmm.3_Missense_Mutation_p.R526L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	548					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CCCTCAGCACGACCCCGCCAC	0.512		NA											20	116					0.00152264	0.00161374	1	0
C1orf124	83932	broad.mit.edu	37	1	231488769	231488769	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:231488769T>C	uc001hur.2	+	5	1580	c.1132T>C	c.(1132-1134)TCC>CCC	p.S378P	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	378					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TTCTAAGATATCCCTAAGAAA	0.418		NA											25	77					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237870464	237870464	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:237870464A>T	uc001hyl.1	+	68	9916	c.9796A>T	c.(9796-9798)ACA>TCA	p.T3266S	RYR2_uc010pxz.1_Missense_Mutation_p.T221S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3266					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGTGCTGCACAGCCCTGAA	0.478		NA											11	60					0	0	0	0
RASSF4	83937	broad.mit.edu	37	10	45480280	45480280	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:45480280G>A	uc001jbo.2	+	6	527	c.393G>A	c.(391-393)GAG>GAA	p.E131E	RASSF4_uc001jbp.2_Silent_p.E162E|RASSF4_uc009xmn.2_Silent_p.E61E|RASSF4_uc001jbq.2_Silent_p.E28E|RASSF4_uc001jbt.2_Silent_p.E88E	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	131					cell cycle|signal transduction		protein binding			large_intestine(1)	1						AGGAGGCAGAGGAGGCCCCCC	0.667		NA											26	205					0	0	0	0
ANUBL1	93550	broad.mit.edu	37	10	46121636	46121636	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:46121636C>T	uc001jcp.3	-	7	1877	c.1635G>A	c.(1633-1635)GAG>GAA	p.E545E	ANUBL1_uc001jcl.3_Silent_p.E65E|ANUBL1_uc001jcm.3_Silent_p.E545E|ANUBL1_uc009xmu.2_Silent_p.E471E|ANUBL1_uc001jcn.3_Silent_p.E471E|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	545							zinc ion binding				0						TATCCCGAGCCTCAACTTTGG	0.398		NA											45	165					0	0	0	0
BICC1	80114	broad.mit.edu	37	10	60546842	60546842	+	Splice_Site	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:60546842G>C	uc001jki.1	+	5	546	c.546_splice	c.e5+1	p.Q182_splice		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1						multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AAGCAACCAGGTGGTTTGTCT	0.353		NA											5	72					0	0	0	0
BTAF1	9044	broad.mit.edu	37	10	93748998	93748998	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:93748998C>A	uc001khr.2	+	20	2613	c.2515C>A	c.(2515-2517)CAA>AAA	p.Q839K	BTAF1_uc001khs.1_Missense_Mutation_p.Q509K|BTAF1_uc001kht.1_Missense_Mutation_p.Q277K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	839	HEAT 5.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ACAGCAGGTCCAAATGACAGT	0.418		NA											10	78					7.48e-07	8.51e-07	1	0
OR52E4	390081	broad.mit.edu	37	11	5905705	5905705	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:5905705G>T	uc010qzs.1	+	1	183	c.183G>T	c.(181-183)ATG>ATT	p.M61I	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCAGCCCATGTTCTACTTCC	0.433		NA											71	251					4.99e-31	6.49e-31	1	0
CALCA	796	broad.mit.edu	37	11	14989331	14989331	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:14989331G>T	uc001mlt.1	-	4	372	c.297C>A	c.(295-297)AGC>AGA	p.S99R	CALCA_uc001mlu.1_RNA	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	99					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	CCCCTGATCTGCTCAGCAAGC	0.542		NA											27	81					3.01e-09	3.52e-09	1	0
DEPDC7	91614	broad.mit.edu	37	11	33054967	33054967	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:33054967A>T	uc001mub.2	+	9	1594	c.1502A>T	c.(1501-1503)CAC>CTC	p.H501L	DEPDC7_uc001muc.2_Missense_Mutation_p.H492L	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	501					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						TATAAGTGTCACCCAGACATC	0.299		NA											35	108					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40135934	40135934	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:40135934C>G	uc001mxa.1	-	2	3873	c.1909G>C	c.(1909-1911)GAG>CAG	p.E637Q	LRRC4C_uc001mxc.1_Missense_Mutation_p.E633Q|LRRC4C_uc001mxd.1_Missense_Mutation_p.E633Q|LRRC4C_uc001mxb.1_Missense_Mutation_p.E633Q	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	637					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				ATTTGAGTCTCTTGTACATTG	0.259		NA											18	97					0	0	0	0
SLC43A3	29015	broad.mit.edu	37	11	57176684	57176684	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:57176684G>A	uc001nkg.2	-	13	1745	c.1335C>T	c.(1333-1335)ACC>ACT	p.T445T	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Silent_p.T445T|SLC43A3_uc010rjr.1_Silent_p.T458T|SLC43A3_uc009yme.2_Silent_p.T445T|SLC43A3_uc001nki.2_Silent_p.T445T	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	445	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)	1						CTTTGATGAGGGTGAAGATGG	0.567		NA											45	168					0	0	0	0
NADSYN1	55191	broad.mit.edu	37	11	71185480	71185480	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:71185480G>T	uc001oqn.2	+	9	832	c.706G>T	c.(706-708)GAC>TAC	p.D236Y	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	236	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGGGTTGTGACGGGGACCG	0.557		NA											18	132					5.46e-16	6.72e-16	1	0
MTNR1B	4544	broad.mit.edu	37	11	92715080	92715080	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:92715080C>T	uc001pdk.1	+	2	794	c.691C>T	c.(691-693)CGC>TGC	p.R231C		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	231	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCTTCAGGCCCGCAGGAAAGC	0.582		NA											21	127					0	0	0	0
BCL9L	283149	broad.mit.edu	37	11	118779003	118779003	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:118779003G>A	uc001pug.2	-	2	1353	c.388C>T	c.(388-390)CCA>TCA	p.P130S	BCL9L_uc009zal.2_Missense_Mutation_p.P125S	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	130					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCCAGGGATGGGGTCCCAGCC	0.592		NA											21	98					0	0	0	0
OR8D4	338662	broad.mit.edu	37	11	123777296	123777296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:123777296G>A	uc010saa.1	+	1	158	c.158G>A	c.(157-159)CGT>CAT	p.R53H		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AGGCTGAATCGTCAACTTCAT	0.408		NA											58	282					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133815961	133815961	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:133815961T>A	uc001qgx.3	-	2	488	c.257A>T	c.(256-258)TAT>TTT	p.Y86F	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	86	Extracellular (Potential).|Ig-like 1.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTTACCTGCATACTCAGGGTC	0.612		NA											4	9					0	0	0	0
SLC6A12	6539	broad.mit.edu	37	12	306025	306025	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:306025A>C	uc001qhz.2	-	12	1642	c.1099T>G	c.(1099-1101)TTC>GTC	p.F367V	SLC6A12_uc001qhx.2_Missense_Mutation_p.F24V|SLC6A12_uc001qhy.2_Intron|SLC6A12_uc001qia.2_Missense_Mutation_p.F367V|SLC6A12_uc001qib.2_Missense_Mutation_p.F367V|SLC6A12_uc009zdh.1_Missense_Mutation_p.F367V	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	367					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GCCTTGGGGAAGGCGATGAAG	0.582		NA											14	73					0	0	0	0
A2M	2	broad.mit.edu	37	12	9256907	9256907	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:9256907G>A	uc001qvk.1	-	11	1307	c.1194C>T	c.(1192-1194)ACC>ACT	p.T398T	A2M_uc009zgk.1_Silent_p.T248T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	398					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTCATCCGTGGTAGCATTGG	0.413		NA											8	31					0	0	0	0
ARID2	196528	broad.mit.edu	37	12	46244170	46244170	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:46244170C>T	uc001ros.1	+	15	2264	c.2264C>T	c.(2263-2265)ACA>ATA	p.T755I	ARID2_uc001ror.2_Missense_Mutation_p.T755I|ARID2_uc009zkg.1_Missense_Mutation_p.T211I|ARID2_uc009zkh.1_Missense_Mutation_p.T382I|ARID2_uc001rou.1_Missense_Mutation_p.T89I	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	755					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CAACCTGTTACAGTTGTGAAT	0.478		NA											20	87					0	0	0	0
LRIG3	121227	broad.mit.edu	37	12	59274631	59274631	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:59274631T>C	uc001sqr.2	-	13	1779	c.1533A>G	c.(1531-1533)ATA>ATG	p.I511M	LRIG3_uc009zqh.2_Missense_Mutation_p.I451M|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	511	Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGGAACCTTTTATTGCCGACT	0.433		NA											69	196					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	73014920	73014920	+	Silent	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:73014920T>C	uc001sxa.2	+	14	2397	c.2367T>C	c.(2365-2367)TAT>TAC	p.Y789Y		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	789	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CAACAACATATATCAAGCTTG	0.313		NA											25	82					0	0	0	0
TCP11L2	255394	broad.mit.edu	37	12	106717343	106717343	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:106717343A>G	uc001tln.2	+	6	865	c.691A>G	c.(691-693)ATG>GTG	p.M231V	TCP11L2_uc001tll.2_Missense_Mutation_p.M231V|TCP11L2_uc001tlm.2_Missense_Mutation_p.M231V	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	231										ovary(3)	3						TTTTACAATTATGAGTCTCAG	0.363		NA											15	79					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112617111	112617111	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:112617111G>A	uc009zwc.2	-	56	9830	c.9812C>T	c.(9811-9813)GCG>GTG	p.A3271V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GATGGGCTTCGCTGGTGTCAG	0.547		NA											7	29					0	0	0	0
TRPC4	7223	broad.mit.edu	37	13	38266248	38266248	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:38266248C>G	uc001uws.2	-	4	1357	c.1122G>C	c.(1120-1122)TTG>TTC	p.L374F	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.L374F|TRPC4_uc010tey.1_Missense_Mutation_p.L374F|TRPC4_uc010abw.2_Missense_Mutation_p.L201F|TRPC4_uc010abx.2_Missense_Mutation_p.L374F|TRPC4_uc010aby.2_Missense_Mutation_p.L374F	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	374	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACAAAAAAGTCAAATAGGAGG	0.483		NA											18	65					0	0	0	0
NALCN	259232	broad.mit.edu	37	13	101763549	101763549	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:101763549C>T	uc001vox.1	-	19	2410	c.2221G>A	c.(2221-2223)GGA>AGA	p.G741R		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	741	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCAAATGATCCGCTCAGCATG	0.493		NA											69	201					0	0	0	0
KLHL28	54813	broad.mit.edu	37	14	45403630	45403630	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:45403630C>A	uc001wvq.2	-	3	1277	c.1031G>T	c.(1030-1032)CGT>CTT	p.R344L	KLHL28_uc001wvr.2_Missense_Mutation_p.R344L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	344	Kelch 2.									ovary(1)	1						GACGCCAGGACGCACATTAGT	0.393		NA											74	98					2.1e-26	2.72e-26	1	0
MDGA2	161357	broad.mit.edu	37	14	47426789	47426789	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:47426789A>C	uc001wwj.3	-	9	1866	c.1670T>G	c.(1669-1671)GTC>GGC	p.V557G	MDGA2_uc001wwi.3_Missense_Mutation_p.V328G|MDGA2_uc010ani.2_Missense_Mutation_p.V117G	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	557	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						ACTCATAGTGACACTTCGATC	0.458		NA											28	118					0	0	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890513	23890513	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:23890513T>A	uc001ywj.3	-	1	663	c.568A>T	c.(568-570)ACC>TCC	p.T190S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AACTGGGAGGTAGCTGGGAAG	0.582		NA											19	79					0	0	0	0
MYO5A	4644	broad.mit.edu	37	15	52672048	52672048	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:52672048G>A	uc002aby.2	-	17	2314	c.2070C>T	c.(2068-2070)ATC>ATT	p.I690I	MYO5A_uc002abx.3_Silent_p.I690I|MYO5A_uc010uge.1_Silent_p.I559I	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	690	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CACTGATTCGGATGGTTTCCA	0.473		NA											43	190					0	0	0	0
UNC13C	440279	broad.mit.edu	37	15	54919300	54919300	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:54919300G>T	uc002ack.2	+	31	6634	c.6634G>T	c.(6634-6636)GAG>TAG	p.E2212*	UNC13C_uc002acm.2_Nonsense_Mutation_p.E133*	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2212					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTACTGAAGAGAGTGCTTG	0.353		NA											12	28					1.09e-07	1.25e-07	1	0
VPS33B	26276	broad.mit.edu	37	15	91557072	91557072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:91557072G>A	uc002bqp.1	-	5	673	c.319C>T	c.(319-321)CGA>TGA	p.R107*	VPS33B_uc002bqq.1_Nonsense_Mutation_p.R16*|VPS33B_uc010uqu.1_Nonsense_Mutation_p.R80*	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	107					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTGCGAGTTCGGCCAGCCAAT	0.493		NA											40	146					0	0	0	0
SOLH	6650	broad.mit.edu	37	16	602492	602492	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:602492A>T	uc002chi.2	+	11	3062	c.2699A>T	c.(2698-2700)CAC>CTC	p.H900L	SOLH_uc002chj.2_5'UTR	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	900					proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				GCCTTCAACCACTGGGGGCCG	0.706		NA											8	24					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20554262	20554262	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:20554262T>G	uc002dhj.3	-	13	1693	c.1483A>C	c.(1483-1485)AGC>CGC	p.S495R	ACSM2B_uc002dhk.3_Missense_Mutation_p.S495R|ACSM2B_uc010bwf.1_Missense_Mutation_p.S495R	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	495					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TCTGGGCTGCTGATCACAGCC	0.483		NA											18	92					0	0	0	0
ZNF423	23090	broad.mit.edu	37	16	49671562	49671562	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:49671562C>T	uc002efs.2	-	5	1799	c.1501G>A	c.(1501-1503)GTC>ATC	p.V501I	ZNF423_uc010vgn.1_Missense_Mutation_p.V384I	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	501	C2H2-type 11.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CAGTGGGAGACGCGGATGTGC	0.562		NA											6	75					0	0	0	0
LPCAT2	54947	broad.mit.edu	37	16	55583314	55583314	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:55583314A>G	uc002eie.3	+	10	1242	c.1061A>G	c.(1060-1062)AAA>AGA	p.K354R	LPCAT2_uc002eic.2_Missense_Mutation_p.K84R	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	354	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						CGAAAATTGAAGTAAGTGTAT	0.363		NA											26	99					0	0	0	0
EDC4	23644	broad.mit.edu	37	16	67911296	67911296	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:67911296A>T	uc002eur.2	+	5	794	c.628A>T	c.(628-630)AAT>TAT	p.N210Y	EDC4_uc010cer.2_5'UTR|EDC4_uc010vkg.1_Missense_Mutation_p.N142Y|EDC4_uc010ces.1_Missense_Mutation_p.N53Y|EDC4_uc002eus.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	210	WD 1.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCTCTGGTTAATGGCAAAAT	0.567		NA											25	65					0	0	0	0
FOXC2	2303	broad.mit.edu	37	16	86601397	86601397	+	Silent	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:86601397C>A	uc002fjq.2	+	1	541	c.456C>A	c.(454-456)TCC>TCA	p.S152S		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	152	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						ACCCGGACTCCTACAACATGT	0.627		NA							Late-onset_Hereditary_Lymphedema				30	98					1.75e-11	2.09e-11	1	0
TP53	7157	broad.mit.edu	37	17	7576853	7576853	+	Silent	SNP	C	C	T	rs11575996		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7576853C>T	uc002gim.2	-	9	1187	c.993G>A	c.(991-993)CAG>CAA	p.Q331Q	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Silent_p.Q331Q|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Silent_p.Q199Q|TP53_uc010cng.1_Silent_p.Q199Q|TP53_uc002gii.1_Silent_p.Q199Q|TP53_uc010cnh.1_Silent_p.Q331Q|TP53_uc010cni.1_Silent_p.Q331Q|TP53_uc002gij.2_Silent_p.Q331Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			56	79					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7755572	7755572	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7755572G>A	uc002giw.1	+	19	4762	c.4386G>A	c.(4384-4386)GTG>GTA	p.V1462V	KDM6B_uc002gix.2_Silent_p.V764V|TMEM88_uc002giy.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1462	JmjC.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GAGACCTCGTGTGGATTAATG	0.607		NA									OREG0024145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	106					0	0	0	0
CHD3	1107	broad.mit.edu	37	17	7801355	7801355	+	Silent	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7801355G>T	uc002gje.2	+	12	2136	c.1986G>T	c.(1984-1986)ACG>ACT	p.T662T	CHD3_uc002gjd.2_Silent_p.T721T|CHD3_uc002gjf.2_Silent_p.T662T|CHD3_uc002gjg.1_Silent_p.T490T	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	662	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				ACCAGTCCACGTGGGAGGAAG	0.483		NA											31	169					3.18e-06	3.58e-06	1	0
PIK3R5	23533	broad.mit.edu	37	17	8792082	8792082	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:8792082G>A	uc002glt.2	-	10	1089	c.1022C>T	c.(1021-1023)GCC>GTC	p.A341V	PIK3R5_uc010vuz.1_Missense_Mutation_p.A341V|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.P290S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	341				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ATCTCTCTCGGCACAGTGCCC	0.502		NA											3	36					0	0	0	0
CCL1	6346	broad.mit.edu	37	17	32688914	32688914	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:32688914C>T	uc002hid.1	-	2	150	c.78G>A	c.(76-78)ATG>ATA	p.M26I		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	26					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		AGGGTACCTGCACTAGAAGAG	0.453		NA									OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	130					0	0	0	0
KRT16	3868	broad.mit.edu	37	17	39767694	39767694	+	Missense_Mutation	SNP	C	C	A	rs142812826	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:39767694C>A	uc002hxg.3	-	3	813	c.674G>T	c.(673-675)CGG>CTG	p.R225L	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	225	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				ATCCAACACCCGGCGCAGGCC	0.622		NA											25	101					4.88e-14	5.89e-14	1	0
WNK4	65266	broad.mit.edu	37	17	40948502	40948502	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:40948502T>A	uc002ibj.2	+	18	3656	c.3635T>A	c.(3634-3636)ATC>AAC	p.I1212N	WNK4_uc010wgx.1_Missense_Mutation_p.I876N|CCDC56_uc010wgz.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1212					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTCCCAGGCATCATGCGAAGG	0.647		NA											22	67					0	0	0	0
POLI	11201	broad.mit.edu	37	18	51800403	51800403	+	Missense_Mutation	SNP	G	G	T	rs142974796	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:51800403G>T	uc002lfj.3	+	3	417	c.349G>T	c.(349-351)GTA>TTA	p.V117L	POLI_uc010xds.1_Missense_Mutation_p.V117L|POLI_uc002lfk.3_Missense_Mutation_p.V14L|POLI_uc002lfl.1_Missense_Mutation_p.V49L	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	117	UmuC.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TCCACAGTTGGTATTAGTTAA	0.348		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					11	27					3.04e-14	3.69e-14	1	0
ZNF236	7776	broad.mit.edu	37	18	74671751	74671751	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:74671751C>G	uc002lmi.2	+	29	5413	c.5215C>G	c.(5215-5217)CGC>GGC	p.R1739G	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1739	C2H2-type 28.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCAGCTGGAGCGCCACAGCCG	0.502		NA											14	65					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	30936347	30936347	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:30936347G>A	uc002nsu.1	+	2	2016	c.1878G>A	c.(1876-1878)ATG>ATA	p.M626I	ZNF536_uc010edd.1_Missense_Mutation_p.M626I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGGGAACATGAAGGAGAAGC	0.597		NA											58	222					0	0	0	0
ZNF83	55769	broad.mit.edu	37	19	53116711	53116711	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:53116711A>G	uc002pzu.3	-	2	2351	c.1107T>C	c.(1105-1107)GGT>GGC	p.G369G	ZNF83_uc002pzv.3_Silent_p.G369G|ZNF83_uc010eps.2_Silent_p.G341G|ZNF83_uc010ept.2_Silent_p.G369G|ZNF83_uc010epu.2_Silent_p.G369G|ZNF83_uc010epv.2_Silent_p.G369G|ZNF83_uc010epw.2_Silent_p.G369G|ZNF83_uc010epx.2_Silent_p.G341G|ZNF83_uc010epy.2_Silent_p.G369G|ZNF83_uc010epz.2_Silent_p.G341G	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	369						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		AAGGTTTCTCACCGGCATGAA	0.393		NA											57	199					0	0	0	0
LILRB2	10288	broad.mit.edu	37	19	54780728	54780728	+	Silent	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:54780728C>G	uc002qfb.2	-	10	1682	c.1416G>C	c.(1414-1416)CTG>CTC	p.L472L	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.L472L|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.L471L|LILRB2_uc010yet.1_Silent_p.L356L	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	472	Helical; (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggaggaggagcagtaggaCGA	0.453		NA											36	124					0	0	0	0
ZIK1	284307	broad.mit.edu	37	19	58102416	58102416	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58102416G>A	uc002qpg.2	+	4	1334	c.1237G>A	c.(1237-1239)GGG>AGG	p.G413R	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.G358R|ZIK1_uc002qpi.2_Missense_Mutation_p.G400R|ZIK1_uc002qpj.2_Missense_Mutation_p.G310R	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	413	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGTGACTGTGGGAAATCCTT	0.458		NA											16	77					0	0	0	0
ZNF418	147686	broad.mit.edu	37	19	58438767	58438767	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58438767C>A	uc002qqs.1	-	4	1074	c.782G>T	c.(781-783)GGA>GTA	p.G261V	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.G176V	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	261	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCCACATTCTCCACATTCATA	0.418		NA											15	210					1.36e-06	1.54e-06	1	0
EML4	27436	broad.mit.edu	37	2	42557100	42557100	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:42557100C>G	uc002rsi.2	+	23	2961	c.2699C>G	c.(2698-2700)CCG>CGG	p.P900R	EML4_uc010fap.2_Missense_Mutation_p.P842R|EML4_uc002rsj.2_Missense_Mutation_p.P589R|EML4_uc010faq.2_Missense_Mutation_p.P245R|EML4_uc010ynv.1_Missense_Mutation_p.P164R	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	900					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						ACTCCCACACCGCCTCCTTCT	0.473		NA	T	ALK	NSCLC								33	133					0	0	0	0
NMS	129521	broad.mit.edu	37	2	101087010	101087010	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:101087010A>G	uc002tan.1	+	1	67	c.60A>G	c.(58-60)CTA>CTG	p.L20L		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	20					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TCTGCATGCTACAGATTCCCT	0.537		NA											34	153					0	0	0	0
BCL2L11	10018	broad.mit.edu	37	2	111907687	111907687	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:111907687G>T	uc002tgv.1	+	3	749	c.461G>T	c.(460-462)CGT>CTT	p.R154L	BCL2L11_uc002tgu.1_Missense_Mutation_p.R94L|BCL2L11_uc002tgw.1_RNA|BCL2L11_uc002tgx.1_RNA|BCL2L11_uc010fkd.1_RNA|BCL2L11_uc002tgy.1_Intron|BCL2L11_uc002tgz.1_Missense_Mutation_p.R64L|BCL2L11_uc010fke.1_Intron|BCL2L11_uc002tha.1_Intron|BCL2L11_uc002thb.1_RNA|BCL2L11_uc002thc.1_RNA|BCL2L11_uc002thd.1_Intron	NM_138621	NP_619527	O43521	B2L11_HUMAN	BCL2-like 11 isoform 1	154	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding|protein binding				0						GAGTTGCGGCGTATTGGAGAC	0.448		NA											11	45					2.1e-16	2.6e-16	1	0
STEAP3	55240	broad.mit.edu	37	2	120003448	120003448	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:120003448C>T	uc002tlp.2	+	3	533	c.376C>T	c.(376-378)CGT>TGT	p.R126C	STEAP3_uc002tlq.2_Missense_Mutation_p.R136C|STEAP3_uc002tlr.2_Missense_Mutation_p.R126C|STEAP3_uc010fle.2_Missense_Mutation_p.R126C	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	126	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						CCTTCAGCATCGTGAGTCCAA	0.582		NA											7	136					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141283518	141283518	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:141283518T>A	uc002tvj.1	-	49	8893	c.7921A>T	c.(7921-7923)ACA>TCA	p.T2641S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2641	Extracellular (Potential).|LDL-receptor class A 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGAACCCTGTGGTTTTCACT	0.383		NA								TSP Lung(27;0.18)			22	64					0	0	0	0
MARCH7	64844	broad.mit.edu	37	2	160604745	160604745	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:160604745A>T	uc002uax.2	+	5	1066	c.944A>T	c.(943-945)TAC>TTC	p.Y315F	MARCH7_uc010foq.2_Missense_Mutation_p.Y315F|MARCH7_uc010zcn.1_Missense_Mutation_p.Y259F|MARCH7_uc010for.2_Missense_Mutation_p.Y277F|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	315	Ser-rich.						ligase activity|zinc ion binding				0						GAAAATTCTTACGTTTCTCCA	0.398		NA											26	94					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228173694	228173694	+	Silent	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:228173694A>T	uc002vom.1	+	49	4704	c.4542A>T	c.(4540-4542)GCA>GCT	p.A1514A	COL4A3_uc002von.1_Silent_p.A1514A|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1514	Required for the anti-angiogenic activity of tumstatin.|Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GTAATTTTGCATCTCGAAATG	0.433		NA											35	106					0	0	0	0
SIRPD	128646	broad.mit.edu	37	20	1532406	1532406	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr20:1532406C>T	uc002wfi.2	-	2	396	c.352G>A	c.(352-354)GTG>ATG	p.V118M		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	118	Ig-like V-type.					extracellular region				ovary(1)|kidney(1)|skin(1)	3						ATGAACTTCACGCAGTAATAG	0.488		NA											22	100					0	0	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31798152	31798152	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:31798152C>A	uc002yob.1	-	1	79	c.79G>T	c.(79-81)GGC>TGC	p.G27C		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	27						intermediate filament				ovary(1)|lung(1)	2						TAGGAAGAGCCACAGGAGGAG	0.567		NA											34	136					2.2e-14	2.69e-14	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072997	17072997	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:17072997G>A	uc002zlp.1	-	1	704	c.444C>T	c.(442-444)CCC>CCT	p.P148P		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	148					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGCCAGGGAGGGCAGTGTGG	0.637		NA											8	48					0	0	0	0
C22orf31	25770	broad.mit.edu	37	22	29454807	29454807	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:29454807A>C	uc003aej.1	-	3	923	c.796T>G	c.(796-798)TTC>GTC	p.F266V		NM_015370	NP_056185	O95567	CV031_HUMAN	hypothetical protein LOC25770	266											0						CTGCCAGGGAACCGGTCCCTC	0.522		NA											17	154					0	0	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39385564	39385564	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39385564C>A	uc003awo.1	+	5	726	c.672C>A	c.(670-672)GAC>GAA	p.D224E	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.D224E|APOBEC3B_uc003awq.1_Intron|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	224					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					AGCGCCTGGACAATGGCACCT	0.562		NA											17	70					1.68e-08	1.95e-08	1	0
APOBEC3D	140564	broad.mit.edu	37	22	39427930	39427930	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39427930T>C	uc011aoe.1	+	6	1048	c.994T>C	c.(994-996)TGC>CGC	p.C332R	APOBEC3D_uc011aof.1_Missense_Mutation_p.C148R|APOBEC3D_uc003awu.3_Missense_Mutation_p.C148R|APOBEC3D_uc003awt.3_Missense_Mutation_p.C332R|APOBEC3D_uc010gxu.2_Missense_Mutation_p.C128R	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	332					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					GGAGGGGCTCTGCAGCCTGAG	0.617		NA											11	139					0	0	0	0
SCUBE1	80274	broad.mit.edu	37	22	43617226	43617226	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:43617226G>C	uc003bdt.1	-	13	1590	c.1502C>G	c.(1501-1503)CCC>CGC	p.P501R		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	501					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CTGGCTGTGGGGCCGGAGGTG	0.642		NA											18	56					0	0	0	0
IL17RC	84818	broad.mit.edu	37	3	9970113	9970113	+	Silent	SNP	T	T	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:9970113T>G	uc003bua.2	+	11	1451	c.1215T>G	c.(1213-1215)GGT>GGG	p.G405G	CIDEC_uc003bto.2_Intron|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Silent_p.G309G|IL17RC_uc003btz.2_Silent_p.G334G|IL17RC_uc011atp.1_Silent_p.G190G|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Silent_p.G319G|IL17RC_uc010hct.2_Silent_p.G334G|IL17RC_uc010hcu.2_Silent_p.G334G|IL17RC_uc010hcv.2_Silent_p.G319G|IL17RC_uc011atq.1_Silent_p.G319G|IL17RC_uc003buc.2_5'UTR|IL17RC_uc003bue.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	405	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GGGCTCCGGGTGGGGACCCCT	0.682		NA											11	57					0	0	0	0
RFT1	91869	broad.mit.edu	37	3	53156407	53156407	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53156407T>C	uc003dgj.2	-	4	493	c.439A>G	c.(439-441)ATG>GTG	p.M147V	RFT1_uc003dgk.2_Missense_Mutation_p.M108V	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	147					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TTCACAAACATATGTGCTTGT	0.443		NA											44	93					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53699745	53699745	+	Silent	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53699745C>A	uc003dgv.3	+	6	988	c.825C>A	c.(823-825)GCC>GCA	p.A275A	CACNA1D_uc003dgu.3_Silent_p.A275A|CACNA1D_uc003dgy.3_Silent_p.A275A|CACNA1D_uc003dgw.3_5'Flank	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	275	Helical; Name=S5 of repeat I; (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCACATAGCCCTTTTGGTAT	0.353		NA											36	148					1.05e-18	1.32e-18	1	0
NPHP3	27031	broad.mit.edu	37	3	132413714	132413714	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:132413714C>A	uc003epe.1	-	16	2344	c.2267G>T	c.(2266-2268)CGG>CTG	p.R756L	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	756					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CATGGACTCCCGGATAGAGTG	0.373		NA											31	157					8.89e-20	1.13e-19	1	0
PLSCR2	57047	broad.mit.edu	37	3	146171942	146171942	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:146171942G>A	uc003evv.1	-	6	663	c.330C>T	c.(328-330)ATC>ATT	p.I110I	PLSCR2_uc003evw.1_Silent_p.I179I	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	110	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						GAGGAGCTTGGATTTCTATCT	0.264		NA											14	56					0	0	0	0
IL12A	3592	broad.mit.edu	37	3	159710911	159710911	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:159710911A>T	uc003fcx.2	+	3	592	c.377A>T	c.(376-378)AAG>ATG	p.K126M	uc003fcw.1_Intron	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	92					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAATTAACCAAGGTATAAAGG	0.383		NA											24	99					0	0	0	0
SERPINI1	5274	broad.mit.edu	37	3	167525118	167525118	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:167525118C>A	uc003ffa.3	+	6	1166	c.968C>A	c.(967-969)ACA>AAA	p.T323K	SERPINI1_uc003ffb.3_Missense_Mutation_p.T323K	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	323					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						GCAAATTTGACAGGCCTCTCT	0.303		NA											26	129					1.85e-09	2.18e-09	1	0
SPATA16	83893	broad.mit.edu	37	3	172835423	172835423	+	Silent	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:172835423G>C	uc003fin.3	-	2	257	c.99C>G	c.(97-99)ACC>ACG	p.T33T		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	33					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GGTGCGCTAAGGTGGACATTT	0.403		NA											207	423					0	0	0	0
CPN2	1370	broad.mit.edu	37	3	194062541	194062541	+	Silent	SNP	G	G	A	rs140809499	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:194062541G>A	uc003fts.2	-	2	981	c.891C>T	c.(889-891)ACC>ACT	p.T297T		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	297	LRR 9.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCTGGTTATGGGTCAGAGACA	0.587		NA											25	64					0	0	0	0
WHSC1	7468	broad.mit.edu	37	4	1957915	1957915	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:1957915G>T	uc003gdz.3	+	15	3057	c.2881G>T	c.(2881-2883)GCA>TCA	p.A961S	WHSC1_uc003geb.3_Missense_Mutation_p.A961S|WHSC1_uc003gec.3_Missense_Mutation_p.A961S|WHSC1_uc003ged.3_Missense_Mutation_p.A961S|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.A180S|WHSC1_uc011bvh.1_Missense_Mutation_p.A22S|WHSC1_uc010icf.2_Missense_Mutation_p.A309S	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	961					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTCAAAAACGGTACGGAGAT	0.463		NA	T	IGH@	MM								15	138					2.32e-05	2.56e-05	1	0
YIPF7	285525	broad.mit.edu	37	4	44626759	44626759	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:44626759G>T	uc010ifx.1	-	5	556	c.539C>A	c.(538-540)GCC>GAC	p.A180D		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	180	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						GCAGCCAATGGCACTCATGCC	0.507		NA											3	15					1.24e-05	1.38e-05	1	0
CXCL10	3627	broad.mit.edu	37	4	76943875	76943875	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:76943875C>G	uc003hjl.3	-	2	227	c.157G>C	c.(157-159)GCA>CCA	p.A53P	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_001565	NP_001556	P02778	CXL10_HUMAN	small inducible cytokine B10 precursor	53					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AATTGGCTTGCAGGAATAATT	0.363		NA											17	103					0	0	0	0
SEC31A	22872	broad.mit.edu	37	4	83770026	83770026	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:83770026C>A	uc003hnf.2	-	20	2597	c.2433G>T	c.(2431-2433)AAG>AAT	p.K811N	SEC31A_uc003hne.2_Missense_Mutation_p.K544N|SEC31A_uc011ccl.1_Missense_Mutation_p.K772N|SEC31A_uc003hnl.2_Missense_Mutation_p.K772N|SEC31A_uc003hng.2_Missense_Mutation_p.K811N|SEC31A_uc003hnh.2_Missense_Mutation_p.K811N|SEC31A_uc003hni.2_Missense_Mutation_p.K811N|SEC31A_uc003hnj.2_Missense_Mutation_p.K772N|SEC31A_uc011ccm.1_Missense_Mutation_p.K806N|SEC31A_uc011ccn.1_Missense_Mutation_p.K811N|SEC31A_uc003hnk.2_Missense_Mutation_p.K772N|SEC31A_uc003hnm.2_Missense_Mutation_p.K811N|SEC31A_uc003hnn.1_Missense_Mutation_p.K811N	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	811	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				CAGGCCTGCCCTTGGGGAGCT	0.488		NA											28	118					1.89e-17	2.36e-17	1	0
ALPK1	80216	broad.mit.edu	37	4	113359713	113359713	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:113359713G>C	uc003iap.3	+	13	3541	c.3262G>C	c.(3262-3264)GCA>CCA	p.A1088P	ALPK1_uc003ian.3_Missense_Mutation_p.A1088P|ALPK1_uc011cfx.1_Missense_Mutation_p.A1010P|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.A916P	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1088	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ACAGATGACCGCACAGCACTA	0.428		NA											39	151					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134071805	134071805	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:134071805C>T	uc003iha.2	+	1	1336	c.510C>T	c.(508-510)GAC>GAT	p.D170D	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.D170D	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	170	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCTCCCTGGACGTGCAGACCC	0.637		NA											20	101					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26988326	26988326	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:26988326C>G	uc003jgs.1	-	2	284	c.115G>C	c.(115-117)GGT>CGT	p.G39R	CDH9_uc010iug.2_Missense_Mutation_p.G39R	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	39					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTGTCAGACCCGCTATCTTT	0.393		NA											32	73					0	0	0	0
ISL1	3670	broad.mit.edu	37	5	50687247	50687247	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:50687247A>T	uc003jor.2	+	5	1453	c.905A>T	c.(904-906)GAC>GTC	p.D302V		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	302	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				TTGCAGAGTGACATAGATCAG	0.498		NA											25	77					0	0	0	0
ESM1	11082	broad.mit.edu	37	5	54275232	54275232	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:54275232A>G	uc003jpk.2	-	3	552	c.483T>C	c.(481-483)ATT>ATC	p.I161I	ESM1_uc010ivt.2_Silent_p.I111I	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	161					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			CTTCTCTCACAATATTGCCAT	0.433		NA											19	134					0	0	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604627	140604627	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:140604627G>C	uc003ljb.2	+	1	1550	c.1550G>C	c.(1549-1551)AGG>ACG	p.R517T	PCDHB14_uc011dal.1_Missense_Mutation_p.R364T	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	517	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCCCTCAGGTCGCTGGAC	0.682		NA											20	153					0	0	0	0
C5orf54	63920	broad.mit.edu	37	5	159821393	159821393	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159821393C>A	uc003lye.1	-	2	1569	c.1105G>T	c.(1105-1107)GAG>TAG	p.E369*	C5orf54_uc003lyf.1_Nonsense_Mutation_p.E369*	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	369										pancreas(1)	1						attttaaactctttattttca	0		NA											20	80					3.52e-12	4.23e-12	1	0
ATP10B	23120	broad.mit.edu	37	5	159992486	159992486	+	Silent	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159992486G>T	uc003lym.1	-	26	5207	c.4360C>A	c.(4360-4362)CGA>AGA	p.R1454R	ATP10B_uc010jit.1_Silent_p.R704R	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1454	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTGGGATCGGCGATGGCTG	0.527		NA											37	100					1.42e-22	1.81e-22	1	0
GRM6	2916	broad.mit.edu	37	5	178413301	178413301	+	Missense_Mutation	SNP	C	C	T	rs150850494		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:178413301C>T	uc003mjr.2	-	8	2133	c.1954G>A	c.(1954-1956)GCC>ACC	p.A652T	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Missense_Mutation_p.A235T|GRM6_uc003mjs.1_Missense_Mutation_p.A272T	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	652	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGCCTGCGGGCGGCACAGACC	0.642		NA											4	21					0	0	0	0
MDC1	9656	broad.mit.edu	37	6	30680344	30680344	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:30680344C>T	uc003nrg.3	-	5	1815	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	MDC1_uc003nrf.3_Missense_Mutation_p.E113K|MDC1_uc011dmp.1_Missense_Mutation_p.E331K|MDC1_uc003nrh.1_Missense_Mutation_p.E331K|MDC1_uc003nri.2_Missense_Mutation_p.E459K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	459	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						AGCTCTTCCTCCTCCACGTCT	0.493		NA						Other_conserved_DNA_damage_response_genes					35	133					0	0	0	0
BTBD9	114781	broad.mit.edu	37	6	38256211	38256211	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:38256211C>A	uc003ooa.3	-	9	1867	c.1291G>T	c.(1291-1293)GCT>TCT	p.A431S	BTBD9_uc003ony.3_Missense_Mutation_p.A363S|BTBD9_uc010jwv.2_Missense_Mutation_p.A392S|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.A431S	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	431					cell adhesion						0						GCACAATCAGCAATTGTTGCA	0.428		NA											18	75					5.35e-07	6.13e-07	1	0
TTK	7272	broad.mit.edu	37	6	80720550	80720550	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:80720550A>G	uc003pjc.2	+	5	563	c.489A>G	c.(487-489)AAA>AAG	p.K163K	TTK_uc003pjb.3_Silent_p.K163K	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	163					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AAAAAAGTAAACAACTTCTTC	0.398		NA											21	51					0	0	0	0
MICAL1	64780	broad.mit.edu	37	6	109773738	109773738	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:109773738C>T	uc003ptj.2	-	4	906	c.652G>A	c.(652-654)GCA>ACA	p.A218T	MICAL1_uc003ptk.2_Missense_Mutation_p.A218T|MICAL1_uc010kdr.2_Missense_Mutation_p.A218T|MICAL1_uc011eaq.1_Missense_Mutation_p.A237T	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	218					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TTACCTCCTGCAGCCGAGATA	0.557		NA											15	43					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146755141	146755141	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:146755141C>A	uc010khw.1	+	9	3264	c.2794C>A	c.(2794-2796)CCC>ACC	p.P932T	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	932	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGTCATCAAGCCCCTCACTAA	0.557		NA											33	136					7.11e-15	8.7e-15	1	0
ZNF12	7559	broad.mit.edu	37	7	6731084	6731084	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:6731084C>A	uc003sqt.1	-	5	2043	c.1489G>T	c.(1489-1491)GAA>TAA	p.E497*	ZNF12_uc011jxa.1_Nonsense_Mutation_p.E335*|ZNF12_uc003sqs.1_Nonsense_Mutation_p.E459*	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	497	C2H2-type 9.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TTTCCACATTCATTACATTCG	0.398		NA											48	180					2.66e-33	3.47e-33	1	0
ABCA13	154664	broad.mit.edu	37	7	48413965	48413965	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:48413965T>G	uc003toq.2	+	34	11180	c.11155T>G	c.(11155-11157)TTT>GTT	p.F3719V	ABCA13_uc010kys.1_Missense_Mutation_p.F793V|ABCA13_uc003tos.1_Missense_Mutation_p.F545V|ABCA13_uc010kyt.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3719	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GACAACCGCCTTTGGACAAGG	0.413		NA											5	19					0	0	0	0
EPHB4	2050	broad.mit.edu	37	7	100414856	100414856	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:100414856C>T	uc003uwn.1	-	8	2037	c.1546G>A	c.(1546-1548)GGG>AGG	p.G516R	EPHB4_uc003uwm.1_Missense_Mutation_p.G423R|EPHB4_uc010lhj.1_Missense_Mutation_p.G516R|EPHB4_uc011kkf.1_Intron|EPHB4_uc011kkg.1_3'UTR	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	516	Extracellular (Potential).|Fibronectin type-III 2.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCGAAGGGCCCGTAGCCGGCC	0.657		NA											7	31					0	0	0	0
IMMP2L	83943	broad.mit.edu	37	7	110303688	110303688	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:110303688C>A	uc003vfq.1	-	6	941	c.498G>T	c.(496-498)GAG>GAT	p.E166D	IMMP2L_uc010ljr.1_Missense_Mutation_p.E166D	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	166					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CTGGTAAGCGCTCTGGAGGAA	0.493		NA											33	110					2.08e-15	2.56e-15	1	0
AHCYL2	23382	broad.mit.edu	37	7	129053482	129053482	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:129053482A>G	uc011kov.1	+	12	1468	c.1414A>G	c.(1414-1416)AGC>GGC	p.S472G	AHCYL2_uc003vot.2_Missense_Mutation_p.S471G|AHCYL2_uc003vov.2_Missense_Mutation_p.S369G|AHCYL2_uc011kow.1_Missense_Mutation_p.S370G|AHCYL2_uc011kox.1_Missense_Mutation_p.S369G	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	472					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						TATGAAGAATAGCTGCATCGT	0.403		NA											23	104					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	69028102	69028102	+	Silent	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:69028102T>C	uc003xxv.1	+	26	3288	c.3261T>C	c.(3259-3261)TTT>TTC	p.F1087F		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1087					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGGTATGTTTTAATGTAGCAG	0.383		NA											33	163					0	0	0	0
SDC2	6383	broad.mit.edu	37	8	97614673	97614673	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:97614673C>T	uc003yhv.1	+	3	841	c.223C>T	c.(223-225)CCA>TCA	p.P75S	SDC2_uc011lgu.1_Missense_Mutation_p.P46S	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	75	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	TCGACCACTTCCAAAGATACT	0.448		NA											36	148					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	114111056	114111056	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:114111056T>C	uc003ynu.2	-	5	1005	c.846A>G	c.(844-846)ATA>ATG	p.I282M	CSMD3_uc003ynt.2_Missense_Mutation_p.I242M|CSMD3_uc011lhx.1_Missense_Mutation_p.I282M|CSMD3_uc010mcx.1_Missense_Mutation_p.I282M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	282	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATCAGTAAATATGAGTGAAA	0.383		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	118					0	0	0	0
ADCY8	114	broad.mit.edu	37	8	131793033	131793033	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:131793033C>T	uc003ytd.3	-	18	3615	c.3359G>A	c.(3358-3360)CGA>CAA	p.R1120Q	ADCY8_uc010mds.2_Missense_Mutation_p.R989Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1120	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCTGTCCATTCGGCTTGCCAG	0.567		NA								HNSCC(32;0.087)			64	304					0	0	0	0
TMEM71	137835	broad.mit.edu	37	8	133764056	133764056	+	Missense_Mutation	SNP	C	C	A	rs111461300	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:133764056C>A	uc003ytp.2	-	4	518	c.289G>T	c.(289-291)GTT>TTT	p.V97F	TMEM71_uc003ytn.2_Missense_Mutation_p.V97F|TMEM71_uc003yto.2_Missense_Mutation_p.V97F	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	97						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTATACATAACGCTGGTCTGG	0.388		NA											54	233					3.22e-24	4.13e-24	1	0
FAM135B	51059	broad.mit.edu	37	8	139164635	139164635	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:139164635C>A	uc003yuy.2	-	13	2254	c.2083G>T	c.(2083-2085)GTC>TTC	p.V695F	FAM135B_uc003yux.2_Missense_Mutation_p.V596F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.V257F|FAM135B_uc003yvb.2_Missense_Mutation_p.V257F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	695										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACCAGGCGACGGAGCTTGGC	0.552		NA								HNSCC(54;0.14)			30	97					1.32e-22	1.69e-22	1	0
TPD52L3	89882	broad.mit.edu	37	9	6330998	6330998	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:6330998G>A	uc003zjx.1	+	2	611	c.390G>A	c.(388-390)ACG>ACA	p.T130T		NM_001001874	NP_001001874	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 2	Error:Variant_position_missing_in_Q96J77_after_alignment							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		ATAAATACACGTTAAATCAAG	0.313		NA											23	118					0	0	0	0
CNTLN	54875	broad.mit.edu	37	9	17236462	17236462	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:17236462A>T	uc003zmz.2	+	5	751	c.725A>T	c.(724-726)AAT>ATT	p.N242I	CNTLN_uc003zmx.3_Missense_Mutation_p.N242I|CNTLN_uc003zmy.2_Missense_Mutation_p.N242I|CNTLN_uc010mio.2_5'UTR	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	242						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GTTATAAAAAATCTGGAGGAG	0.378		NA											30	142					0	0	0	0
C9orf135	138255	broad.mit.edu	37	9	72472845	72472845	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:72472845C>T	uc004ahl.2	+	4	466	c.401C>T	c.(400-402)ACA>ATA	p.T134I	C9orf135_uc011lrw.1_Missense_Mutation_p.T26I|C9orf135_uc010moq.2_Missense_Mutation_p.T26I|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Missense_Mutation_p.T134I	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	134	Helical; (Potential).					integral to membrane				ovary(1)	1						TTGCCTGCCACAGGTTTTGGA	0.368		NA											71	129					0	0	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617803	111617803	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:111617803G>A	uc004bdi.2	-	1	473	c.408C>T	c.(406-408)ACC>ACT	p.T136T		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	136						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCTTCATGGCGGTGCGGAAGA	0.622		NA											32	60					0	0	0	0
SCAI	286205	broad.mit.edu	37	9	127765428	127765428	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:127765428T>A	uc004bpe.2	-	11	1111	c.1030A>T	c.(1030-1032)AGC>TGC	p.S344C	SCAI_uc004bpd.2_Missense_Mutation_p.S367C|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	344					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TATAGCTGGCTGAAGGTTGGT	0.383		NA											193	340					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139401756	139401756	+	Splice_Site	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:139401756C>T	uc004chz.2	-	22	3643	c.3643_splice	c.e22+1	p.G1215_splice	NOTCH1_uc004cia.1_Splice_Site_p.G445_splice	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGGCCCTTACCCTGAGTGCC	0.692		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			24	49					0	0	0	0
KDM6A	7403	broad.mit.edu	37	X	44929602	44929602	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:44929602G>T	uc004dge.3	+	17	3077	c.2702G>T	c.(2701-2703)AGG>ATG	p.R901M	KDM6A_uc010nhk.2_Missense_Mutation_p.R867M|KDM6A_uc011mkz.1_Missense_Mutation_p.R953M|KDM6A_uc011mla.1_Missense_Mutation_p.R856M|KDM6A_uc011mlb.1_Missense_Mutation_p.R908M|KDM6A_uc011mlc.1_Missense_Mutation_p.R605M|KDM6A_uc011mld.1_Missense_Mutation_p.R540M	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	901					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAGGCATGCAGGTTAGTGTGG	0.418		NA	D|N|F|S		renal|oesophageal SCC|MM								9	13					4.69e-08	5.4e-08	1	0
COL24A1	255631	broad.mit.edu	37	1	86591796	86591796	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:86591796delC	uc001dlj.2	-	3	265	c.223delG	c.(223-225)GTCfs	p.V75fs	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Frame_Shift_Del_p.V75fs	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	75	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTTAAATGGACCCCCTGAGGT	0.428		NA											7	101	---	---	---	---	NA	NA	NA	NA
USP35	57558	broad.mit.edu	37	11	77921387	77921388	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:77921387_77921388insC	uc009yva.1	+	10	2732_2733	c.2486_2487insC	c.(2485-2487)ATCfs	p.I829fs	USP35_uc001oze.2_Frame_Shift_Ins_p.I585fs|USP35_uc001ozc.2_Frame_Shift_Ins_p.I397fs|USP35_uc010rsp.1_Frame_Shift_Ins_p.I261fs|USP35_uc001ozd.2_Frame_Shift_Ins_p.I440fs|USP35_uc001ozf.2_Frame_Shift_Ins_p.I560fs	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	829					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GACGTCTCCATCCCCCTGCTGC	0.634		NA											18	171	---	---	---	---	NA	NA	NA	NA
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:43969653_43969655delAGC	uc002owl.1	-	1	177_179	c.69_71delGCT	c.(67-72)CTGCTT>CTT	p.23_24LL>L	LYPD3_uc002owm.2_In_Frame_Del_p.23_24LL>L	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	23_24						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675		NA											7	226	---	---	---	---	NA	NA	NA	NA
NR4A2	4929	broad.mit.edu	37	2	157182714	157182715	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:157182714_157182715insA	uc002tyz.3	-	7	1909_1910	c.1487_1488insT	c.(1486-1488)ATGfs	p.M496fs	NR4A2_uc002tyx.3_Frame_Shift_Ins_p.M433fs|NR4A2_uc010zcf.1_Frame_Shift_Ins_p.M496fs|NR4A2_uc010zcg.1_Frame_Shift_Ins_p.*78fs	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	496					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TGTCGATGTTCATATTCTGCAA	0.515		NA											22	71	---	---	---	---	NA	NA	NA	NA
ZNF295	49854	broad.mit.edu	37	21	43413874	43413875	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:43413874_43413875insC	uc002zab.3	-	3	544_545	c.330_331insG	c.(328-333)GGGATTfs	p.G110fs	ZNF295_uc002yzz.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc002yzy.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc002zaa.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc010gov.1_Frame_Shift_Ins_p.G110fs|ZNF295_uc002zac.2_Frame_Shift_Ins_p.G110fs	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	110_111					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGAAAGGAAATCCCAAGACTAT	0.376		NA											16	50	---	---	---	---	NA	NA	NA	NA
RUNX1T1	862	broad.mit.edu	37	8	93017415	93017415	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:93017415delG	uc003yfd.2	-	5	753	c.669delC	c.(667-669)ACCfs	p.T223fs	RUNX1T1_uc003yfc.1_Frame_Shift_Del_p.T196fs|RUNX1T1_uc003yfe.1_Frame_Shift_Del_p.T186fs|RUNX1T1_uc010mao.2_Frame_Shift_Del_p.T196fs|RUNX1T1_uc011lgi.1_Frame_Shift_Del_p.T234fs|RUNX1T1_uc003yfb.1_Frame_Shift_Del_p.T186fs|RUNX1T1_uc003yff.1_Frame_Shift_Del_p.T186fs	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	223					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGGTGAGGTGGTGCTGGCAT	0.592		NA											41	197	---	---	---	---	NA	NA	NA	NA
SLITRK4	139065	broad.mit.edu	37	X	142718162	142718163	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:142718162_142718163insT	uc004fbx.2	-	2	1138_1139	c.762_763insA	c.(760-765)AAAGAAfs	p.K254fs	SLITRK4_uc004fby.2_Frame_Shift_Ins_p.K254fs	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	254_255	Extracellular (Potential).|LRRCT 1.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTTGGTTTCTTTTAAAAGCC	0.45		NA											19	47	---	---	---	---	NA	NA	NA	NA
