Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7805922	7805922	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:7805922C>G	uc001aoi.2	+	18	4595	c.4388C>G	c.(4387-4389)CCT>CGT	p.P1463R	CAMTA1_uc001aok.3_Missense_Mutation_p.P506R|CAMTA1_uc001aoj.2_Missense_Mutation_p.P419R|CAMTA1_uc009vmf.2_Intron	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TATAACGAGCCTCTAACCCCT	0.458		NA											40	247					0	0	0	0
GRHL3	57822	broad.mit.edu	37	1	24669215	24669215	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:24669215G>A	uc001biy.2	+	10	1299	c.1253G>A	c.(1252-1254)CGG>CAG	p.R418Q	GRHL3_uc001bix.2_Missense_Mutation_p.R413Q|GRHL3_uc001biz.2_Missense_Mutation_p.R320Q	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	413					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATGACGAGCGGAAGCAGTTC	0.627		NA											16	191					0	0	0	0
RCC1	1104	broad.mit.edu	37	1	28862414	28862414	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:28862414G>A	uc001bqg.1	+	7	778	c.693G>A	c.(691-693)CTG>CTA	p.L231L	SNHG3-RCC1_uc001bqa.1_Silent_p.L231L|SNHG3-RCC1_uc001bqb.1_Silent_p.L231L|SNHG3-RCC1_uc001bqc.1_Silent_p.L231L|RCC1_uc001bqe.1_Silent_p.L248L|RCC1_uc001bqf.1_Silent_p.L262L	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	231	RCC1 4.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GTGTGATGCTGAAATCCAGGG	0.562		NA											24	261					0	0	0	0
NRD1	4898	broad.mit.edu	37	1	52289446	52289446	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:52289446G>A	uc001ctc.3	-	9	1575	c.1253C>T	c.(1252-1254)ACG>ATG	p.T418M	NRD1_uc009vzb.2_Missense_Mutation_p.T113M|NRD1_uc001ctd.3_Missense_Mutation_p.T350M|NRD1_uc001cte.2_Missense_Mutation_p.T286M|NRD1_uc001ctf.2_Missense_Mutation_p.T350M|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.T218M	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	349					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						ATGCTTGAGCGTCTCAGCATT	0.313		NA											6	84					0	0	0	0
LRRC42	115353	broad.mit.edu	37	1	54417937	54417937	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:54417937C>T	uc001cwj.1	+	2	465	c.265C>T	c.(265-267)CTC>TTC	p.L89F	LRRC42_uc001cwl.1_Missense_Mutation_p.L89F|LRRC42_uc001cwk.1_Missense_Mutation_p.L89F|LRRC42_uc009vzm.1_Missense_Mutation_p.L89F	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	89											0						CGCCAAATCCCTCTTCAGCCT	0.483		NA											13	168					0	0	0	0
BCL10	8915	broad.mit.edu	37	1	85733597	85733597	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:85733597C>T	uc001dkz.2	-	4	1120	c.415G>A	c.(415-417)GAT>AAT	p.D139N		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	139					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTACTCTCATCTGAATTTGAT	0.388		NA	T	IGH@	MALT 								28	184					0	0	0	0
UBAP2L	9898	broad.mit.edu	37	1	154199771	154199771	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:154199771A>C	uc001fep.3	+	3	271	c.104A>C	c.(103-105)CAA>CCA	p.Q35P	UBAP2L_uc009wot.2_Missense_Mutation_p.Q35P|UBAP2L_uc010pek.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pel.1_Missense_Mutation_p.Q34P|UBAP2L_uc001fen.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pem.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pen.1_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	35					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACTGCAGAACAAATTAGACTT	0.418		NA											17	187					0	0	0	0
OR10J3	441911	broad.mit.edu	37	1	159283758	159283758	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:159283758G>A	uc010piu.1	-	1	692	c.692C>T	c.(691-693)TCA>TTA	p.S231L		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					ACCTTCAGCTGAGGCAATCTT	0.493		NA											38	138					0	0	0	0
SLAMF8	56833	broad.mit.edu	37	1	159802746	159802746	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:159802746T>A	uc001fue.3	+	3	658	c.448T>A	c.(448-450)TTG>ATG	p.L150M		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	150	Ig-like C2-type.|Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CCAGGTTTTCTTGTCCTGTTG	0.532		NA											15	148					0	0	0	0
BLZF1	8548	broad.mit.edu	37	1	169349768	169349768	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:169349768A>T	uc001gfx.1	+	5	1155	c.718A>T	c.(718-720)AAC>TAC	p.N240Y	BLZF1_uc001gfy.2_Missense_Mutation_p.N240Y|BLZF1_uc009wvp.1_Missense_Mutation_p.N217Y	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	240					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					ACAGCGTCAAAACCGTGATGC	0.393		NA											7	106					0	0	0	0
RD3	343035	broad.mit.edu	37	1	211654485	211654485	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:211654485G>A	uc001him.2	-	2	1437	c.273C>T	c.(271-273)TCC>TCT	p.S91S	RD3_uc001hin.2_RNA|RD3_uc009xda.2_Intron	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	91					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GCCCACAATAGGATGGGTGGA	0.617		NA											17	45					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216348688	216348688	+	Silent	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:216348688A>T	uc001hku.1	-	21	4920	c.4533T>A	c.(4531-4533)GCT>GCA	p.A1511A	USH2A_uc001hkv.2_Silent_p.A1511A	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1511	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTCATCAGAGCTGGTAGAG	0.443		NA								HNSCC(13;0.011)			7	90					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228465484	228465484	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:228465484G>C	uc009xez.1	+	25	6828	c.6784G>C	c.(6784-6786)GTC>CTC	p.V2262L	OBSCN_uc001hsn.2_Missense_Mutation_p.V2262L|OBSCN_uc001hsp.1_5'UTR|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2262					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTACCGGAGAGTCCTGGCGGA	0.622		NA											7	62					0	0	0	0
CAPN9	10753	broad.mit.edu	37	1	230898463	230898463	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:230898463G>A	uc001htz.1	+	4	580	c.467G>A	c.(466-468)CGC>CAC	p.R156H	CAPN9_uc009xfg.1_Missense_Mutation_p.R93H|CAPN9_uc001hua.1_Missense_Mutation_p.R156H	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	156	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TTCAGGGACCGCTTGGTTTTC	0.577		NA											28	87					0	0	0	0
ADARB2	105	broad.mit.edu	37	10	1405308	1405308	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:1405308G>A	uc009xhq.2	-	3	1366	c.992C>T	c.(991-993)GCC>GTC	p.A331V		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	331	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GGCCTGCGCGGCCTGACCCCG	0.751		NA											3	21					0	0	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344239	38344239	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:38344239A>T	uc001izh.2	+	5	1362	c.1184A>T	c.(1183-1185)CAT>CTT	p.H395L	ZNF33A_uc001izg.2_Missense_Mutation_p.H396L|ZNF33A_uc010qev.1_Missense_Mutation_p.H402L|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	395	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GCCTTTAGCCATAAGTCAGCC	0.423		NA											11	138					0	0	0	0
ZNF239	8187	broad.mit.edu	37	10	44053142	44053142	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:44053142G>A	uc001jaw.3	-	2	1039	c.386C>T	c.(385-387)TCG>TTG	p.S129L	ZNF239_uc001jax.3_Missense_Mutation_p.S129L|ZNF239_uc009xmj.2_Missense_Mutation_p.S129L|ZNF239_uc009xmk.2_Missense_Mutation_p.S129L	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						TAACAATGGCGAGGCCAGTTC	0.413		NA											9	239					0	0	0	0
RGR	5995	broad.mit.edu	37	10	86012692	86012692	+	Silent	SNP	C	C	A	rs141356847		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:86012692C>A	uc001kdc.1	+	4	476	c.438C>A	c.(436-438)CCC>CCA	p.P146P	RGR_uc001kdd.1_Silent_p.P150P|RGR_uc001kde.1_Silent_p.P146P	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	146	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CAGCTCTGCCCCTTCTGGGTT	0.607		NA											9	112					5.17e-11	6.46e-11	1	0
GRID1	2894	broad.mit.edu	37	10	87614257	87614257	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:87614257C>T	uc001kdl.1	-	8	1330	c.1229G>A	c.(1228-1230)CGC>CAC	p.R410H	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	410	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GCTTACCTTGCGCATGTCTTT	0.512		NA								Multiple Myeloma(13;0.14)			9	65					0	0	0	0
C10orf96	374355	broad.mit.edu	37	10	118100359	118100359	+	Silent	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:118100359C>A	uc001lck.2	+	4	530	c.279C>A	c.(277-279)ACC>ACA	p.T93T		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	93										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		TTCTTCAAACCTTTGTAAGTT	0.284		NA											11	118					0.00010058	0.000116196	1	0
OR52E2	119678	broad.mit.edu	37	11	5080058	5080058	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:5080058C>T	uc010qyw.1	-	1	800	c.800G>A	c.(799-801)CGA>CAA	p.R267Q		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGGCACATTTCGGCCAAAGCG	0.478		NA											4	101					0	0	0	0
OR52A4	390053	broad.mit.edu	37	11	5142432	5142432	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:5142432C>T	uc001lzz.1	-	1	377	c.377G>A	c.(376-378)CGC>CAC	p.R126H	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CGCTACACAGCGGTCCAGAGC	0.473		NA											5	50					0	0	0	0
OR52B2	255725	broad.mit.edu	37	11	6191298	6191298	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:6191298A>C	uc010qzy.1	-	1	259	c.259T>G	c.(259-261)TTT>GTT	p.F87V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGAAGCCAAAAGATGGCTAGG	0.493		NA											16	160					0	0	0	0
SERGEF	26297	broad.mit.edu	37	11	17981067	17981067	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:17981067G>A	uc001mnm.2	-	9	1041	c.961C>T	c.(961-963)CCA>TCA	p.P321S	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Intron|SERGEF_uc010rcz.1_Intron|SERGEF_uc001mno.1_Missense_Mutation_p.P207S	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	321	RCC1 6.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						CTGTTCGGTGGTCTTGAACAG	0.468		NA											11	76					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22296150	22296150	+	Silent	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:22296150C>A	uc001mqi.2	+	20	2588	c.2271C>A	c.(2269-2271)CCC>CCA	p.P757P	ANO5_uc001mqj.2_Silent_p.P756P	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	757	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ACATCATTCCCCGTCTAGTTT	0.358		NA											10	171					0.000978159	0.00110389	1	0
PTPRJ	5795	broad.mit.edu	37	11	48181492	48181492	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:48181492A>T	uc001ngp.3	+	22	3804	c.3449A>T	c.(3448-3450)GAG>GTG	p.E1150V		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1150	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ACCAAATGTGAGGAGTATTGG	0.423		NA											16	148					0	0	0	0
APLNR	187	broad.mit.edu	37	11	57003872	57003872	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:57003872C>G	uc001njo.2	-	1	1056	c.607G>C	c.(607-609)GTC>CTC	p.V203L	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	203	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						GTGGACGAGACCCCAAGGCCC	0.592		NA											8	69					0	0	0	0
ZFP91	80829	broad.mit.edu	37	11	58384739	58384739	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:58384739G>A	uc001nmx.3	+	11	1441	c.1273G>A	c.(1273-1275)GAC>AAC	p.D425N	ZFP91_uc001nmy.3_Missense_Mutation_p.D424N|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	425					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ACATGATGCAGACTCCTTCTA	0.428		NA											11	132					0	0	0	0
MS4A6A	64231	broad.mit.edu	37	11	59943062	59943062	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:59943062C>T	uc001nor.2	-	5	600	c.362G>A	c.(361-363)AGC>AAC	p.S121N	MS4A6A_uc001noq.2_Missense_Mutation_p.S121N|MS4A6A_uc001nos.3_Missense_Mutation_p.S149N|MS4A6A_uc009ymv.2_Missense_Mutation_p.S121N|MS4A6A_uc001not.2_Missense_Mutation_p.S121N|MS4A6A_uc010rla.1_Missense_Mutation_p.S149N|MS4A6A_uc010rlb.1_Missense_Mutation_p.S76N	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	121	Helical; (Potential).					integral to membrane	receptor activity				0						ACTCAGAATGCTTCCAACCAG	0.438		NA											35	84					0	0	0	0
INTS5	80789	broad.mit.edu	37	11	62415548	62415548	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:62415548G>A	uc001nud.2	-	2	2057	c.2004C>T	c.(2002-2004)GCC>GCT	p.A668A	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	668					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GACAGGCTGAGGCCACACCTG	0.612		NA											4	71					0	0	0	0
MAP3K11	4296	broad.mit.edu	37	11	65381159	65381159	+	Silent	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:65381159A>C	uc001oew.2	-	1	562	c.69T>G	c.(67-69)GGT>GGG	p.G23G	MAP3K11_uc010rol.1_5'Flank|PCNXL3_uc001oey.2_5'Flank	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	23	Gly-rich.|Poly-Gly.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						CGCCCCCACCACCCCCGCTGC	0.667		NA											3	13					0	0	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73074856	73074856	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:73074856G>A	uc001otu.2	+	16	5332	c.5311G>A	c.(5311-5313)GCG>ACG	p.A1771T		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1771					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GCTCCAGCATGCGGCCTCTGT	0.582		NA											17	85					0	0	0	0
NARS2	79731	broad.mit.edu	37	11	78176976	78176976	+	Silent	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:78176976T>C	uc001ozi.2	-	11	1486	c.1110A>G	c.(1108-1110)CCA>CCG	p.P370P	NARS2_uc010rsq.1_Silent_p.P143P	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	370					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	TGAGTGTTAATGGATAATTAA	0.428		NA											10	120					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92085715	92085715	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:92085715T>C	uc001pdj.3	+	1	454	c.437T>C	c.(436-438)ATA>ACA	p.I146T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	146	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAAGTGAATATACAGGTTTTA	0.378		NA								TCGA Ovarian(4;0.039)			6	61					0	0	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120352147	120352147	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:120352147C>T	uc001pxl.1	+	39	4423	c.4416C>T	c.(4414-4416)CCC>CCT	p.P1472P	ARHGEF12_uc009zau.1_Silent_p.P1369P	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1472					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CATTCACCCCCGAATTTCTGG	0.532		NA	T	MLL	AML								6	95					0	0	0	0
SIAE	54414	broad.mit.edu	37	11	124524555	124524555	+	Silent	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:124524555G>C	uc001qan.2	-	4	653	c.540C>G	c.(538-540)ACC>ACG	p.T180T		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	180						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		ACATACCTGAGGTGGGCTTAG	0.483		NA											21	234					0	0	0	0
ACAD8	27034	broad.mit.edu	37	11	134131756	134131756	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:134131756A>T	uc001qhk.2	+	9	1125	c.1064A>T	c.(1063-1065)AAG>ATG	p.K355M	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.K278M|ACAD8_uc001qhl.2_Missense_Mutation_p.K228M	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	355					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		TCCATGGCCAAGCTCTTTGCT	0.582		NA											4	54					0	0	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457162	6457162	+	Silent	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:6457162T>C	uc001qnx.2	-	13	2176	c.1887A>G	c.(1885-1887)CCA>CCG	p.P629P	SCNN1A_uc001qnv.2_Silent_p.P329P|SCNN1A_uc001qnw.2_Silent_p.P688P|SCNN1A_uc010sfb.1_Silent_p.P652P	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	629	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	gagcagggcctggctgggaca	0.219		NA											4	14					0	0	0	0
RIMKLB	57494	broad.mit.edu	37	12	8926168	8926168	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:8926168T>C	uc001quu.2	+	6	1200	c.949T>C	c.(949-951)TCC>CCC	p.S317P	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.S317P|RIMKLB_uc010sgl.1_Missense_Mutation_p.S317P|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	317					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CCGGCGTATGTCCCTGCTCTC	0.562		NA											29	108					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944862	43944862	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:43944862G>A	uc010skx.1	-	2	303	c.303C>T	c.(301-303)GCC>GCT	p.A101A		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	101						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGTAGCCGGCGGCCAGAAAGG	0.682		NA											8	18					0	0	0	0
ENOX1	55068	broad.mit.edu	37	13	43918857	43918857	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:43918857C>T	uc001uza.3	-	9	1153	c.853G>A	c.(853-855)GTG>ATG	p.V285M	ENOX1_uc001uzb.3_Missense_Mutation_p.V285M|ENOX1_uc001uzc.3_Missense_Mutation_p.V285M|ENOX1_uc001uyz.3_Translation_Start_Site|ENOX1_uc010tfm.1_Missense_Mutation_p.V98M	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	285					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GAAAGCAGCACTGTGATAGCC	0.468		NA											8	85					0	0	0	0
KLHL1	57626	broad.mit.edu	37	13	70456501	70456501	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:70456501T>A	uc001vip.2	-	5	1935	c.1141A>T	c.(1141-1143)ATG>TTG	p.M381L	KLHL1_uc010thm.1_Missense_Mutation_p.M320L	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	381					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGACCCACATCATCAATGCA	0.443		NA											27	110					0	0	0	0
DACH1	1602	broad.mit.edu	37	13	72204713	72204713	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:72204713T>A	uc010thn.1	-	4	1524	c.1101A>T	c.(1099-1101)GAA>GAT	p.E367D	DACH1_uc010tho.1_Missense_Mutation_p.E367D|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	367	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGTCCCCGTTTTCAGAGTCTG	0.333		NA											46	473					0	0	0	0
OR4K1	79544	broad.mit.edu	37	14	20404174	20404174	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:20404174G>T	uc001vwj.1	+	1	349	c.349G>T	c.(349-351)GCT>TCT	p.A117S		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTTGCTTGTAGCTATGGCATA	0.418		NA											16	163					0.000422831	0.000483393	1	0
SDCCAG1	9147	broad.mit.edu	37	14	50312960	50312960	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:50312960C>T	uc001wxc.2	-	4	323	c.255G>A	c.(253-255)CGG>CGA	p.R85R	SDCCAG1_uc010anj.1_Silent_p.R85R|SDCCAG1_uc010tqi.1_Silent_p.R85R|SDCCAG1_uc001wxe.2_Intron|SDCCAG1_uc010anq.1_5'UTR	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	85						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TGACTAATCTCCGACTCTTCA	0.343		NA											5	115					0	0	0	0
EXOC5	10640	broad.mit.edu	37	14	57676773	57676773	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:57676773T>G	uc001xct.2	-	16	1871	c.1620A>C	c.(1618-1620)TTA>TTC	p.L540F	EXOC5_uc001xcs.2_Missense_Mutation_p.L219F|EXOC5_uc010trg.1_Missense_Mutation_p.L485F|EXOC5_uc010trh.1_Missense_Mutation_p.L475F	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	540					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						TCATACAATTTAATGTCCTAG	0.269		NA											6	30					0	0	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256577	69256577	+	Silent	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:69256577A>T	uc001xkh.1	-	2	820	c.690T>A	c.(688-690)CCT>CCA	p.P230P	ZFP36L1_uc001xki.1_Silent_p.P230P	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	230					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGCTCAGAATAGGGGGTGGGG	0.532		NA									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	197					0	0	0	0
MKRN3	7681	broad.mit.edu	37	15	23811027	23811027	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:23811027C>T	uc001ywh.3	+	1	574	c.98C>T	c.(97-99)CCC>CTC	p.P33L	MKRN3_uc001ywi.2_Missense_Mutation_p.P33L|MKRN3_uc010ayi.1_Missense_Mutation_p.P33L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	33						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding	p.P33P(1)		lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CCGGACCTTCCCGTCTGTGAG	0.682		NA											8	91					0	0	0	0
RPUSD2	27079	broad.mit.edu	37	15	40866110	40866110	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:40866110C>A	uc001zmd.1	+	3	1288	c.1288C>A	c.(1288-1290)CTC>ATC	p.L430I		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	430					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TGTGCTAGATCTCTGTGAGGG	0.597		NA											16	123					1.16e-05	1.37e-05	1	0
RASGRF1	5923	broad.mit.edu	37	15	79254558	79254558	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:79254558G>T	uc002beq.2	-	28	4125	c.3750C>A	c.(3748-3750)GAC>GAA	p.D1250E	RASGRF1_uc002bep.2_Missense_Mutation_p.D1234E|RASGRF1_uc002beo.2_Missense_Mutation_p.D466E	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1252	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CAAAAGATTGGTCCAGTAAAT	0.463		NA											5	21					1.07e-07	1.3e-07	1	0
MTHFS	10588	broad.mit.edu	37	15	80181668	80181668	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:80181668G>A	uc002bex.3	-	2	186	c.146C>T	c.(145-147)TCC>TTC	p.S49F		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	49					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		AATTCTTTTGGACTTTTGATA	0.378		NA											8	179					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81592045	81592045	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:81592045G>A	uc002bgh.3	+	14	2754	c.2378G>A	c.(2377-2379)CGC>CAC	p.R793H	IL16_uc010blq.1_Missense_Mutation_p.R747H|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.R835H|IL16_uc002bgg.2_Missense_Mutation_p.R793H|IL16_uc002bgi.1_Missense_Mutation_p.R183H|IL16_uc002bgj.2_Missense_Mutation_p.R287H|IL16_uc002bgk.2_Missense_Mutation_p.R92H|IL16_uc002bgl.1_Missense_Mutation_p.R92H|IL16_uc010unq.1_Missense_Mutation_p.R92H	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	793					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GCCTGGTTTCGCCAAAGCTTG	0.562		NA											6	134					0	0	0	0
RHBDF1	64285	broad.mit.edu	37	16	110495	110495	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:110495C>T	uc002cfl.3	-	15	1748	c.1600G>A	c.(1600-1602)GCC>ACC	p.A534T		NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	534	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				AGCTCTGGGGCGCTGGGATGG	0.632		NA											11	113					0	0	0	0
ABAT	18	broad.mit.edu	37	16	8866736	8866736	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:8866736G>A	uc002czc.3	+	12	1082	c.916G>A	c.(916-918)GAT>AAT	p.D306N	ABAT_uc002czd.3_Missense_Mutation_p.D306N|ABAT_uc010buh.2_Missense_Mutation_p.D248N|ABAT_uc010bui.2_Missense_Mutation_p.D306N	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	306					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCACGCATCCGATGACTTCTT	0.552		NA											5	56					0	0	0	0
ABCC1	4363	broad.mit.edu	37	16	16101762	16101762	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:16101762C>T	uc010bvi.2	+	2	313	c.138C>T	c.(136-138)CTC>CTT	p.L46L	ABCC1_uc010bvj.2_Silent_p.L46L|ABCC1_uc010bvk.2_Silent_p.L46L|ABCC1_uc010bvl.2_Silent_p.L46L|ABCC1_uc010bvm.2_Silent_p.L46L|ABCC1_uc002del.3_5'Flank	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	46	Helical; Name=1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTTTTTACCTCTGGGCCTGTT	0.507		NA											16	201					0	0	0	0
PRKCB	5579	broad.mit.edu	37	16	24192240	24192240	+	Silent	SNP	C	C	A	rs17847876		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:24192240C>A	uc002dmd.2	+	13	1721	c.1524C>A	c.(1522-1524)ATC>ATA	p.I508I	PRKCB_uc002dme.2_Silent_p.I508I	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	508	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CAGACTACATCGCCCCCGAGG	0.542		NA											15	130					7.93e-07	9.52e-07	1	0
NAE1	8883	broad.mit.edu	37	16	66837006	66837006	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:66837006T>C	uc002eqf.2	-	20	1588	c.1511A>G	c.(1510-1512)GAG>GGG	p.E504G	NAE1_uc002eqe.2_Missense_Mutation_p.E498G|NAE1_uc002eqg.2_Missense_Mutation_p.E415G|NAE1_uc010cdv.2_Missense_Mutation_p.E507G|CCDC79_uc010viv.1_5'Flank|CCDC79_uc002eqc.1_5'Flank|CCDC79_uc002eqd.1_5'Flank	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	504					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TTTGATGACCTCTTGAGCAGC	0.328		NA											7	63					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578247	7578247	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:7578247A>T	uc002gim.2	-	6	796	c.602T>A	c.(601-603)TTG>TAG	p.L201*	TP53_uc002gig.1_Nonsense_Mutation_p.L201*|TP53_uc002gih.2_Nonsense_Mutation_p.L201*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.L69*|TP53_uc010cng.1_Nonsense_Mutation_p.L69*|TP53_uc002gii.1_Nonsense_Mutation_p.L69*|TP53_uc010cnh.1_Nonsense_Mutation_p.L201*|TP53_uc010cni.1_Nonsense_Mutation_p.L201*|TP53_uc002gij.2_Nonsense_Mutation_p.L201*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.L108*|TP53_uc002gio.2_Nonsense_Mutation_p.L69*|TP53_uc010vug.1_Nonsense_Mutation_p.L162*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	201	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> S (in a sporadic cancer; somatic mutation).|LR -> FC (in a sporadic cancer; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L201F(7)|p.L201fs*46(4)|p.K164_P219del(1)|p.E198_L201>V(1)|p.N200fs*4(1)|p.L201P(1)|p.L201S(1)|p.E198fs*7(1)|p.L201fs*8(1)|p.P191fs*6(1)|p.L201_R202>FC(1)|p.L201L(1)|p.G199fs*42(1)|p.L201*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCCACACGCAAATTTCCTTC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	64					0	0	0	0
PFAS	5198	broad.mit.edu	37	17	8170877	8170877	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:8170877C>T	uc002gkr.2	+	26	3417	c.3276C>T	c.(3274-3276)GAC>GAT	p.D1092D	PFAS_uc010vuv.1_Silent_p.D668D|PFAS_uc002gks.2_Silent_p.D171D	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1092	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGGTATGGGACGTGACCATGC	0.637		NA											18	155					0	0	0	0
CDRT1	374286	broad.mit.edu	37	17	15522822	15522822	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:15522822T>C	uc002gov.3	-	1	197	c.5A>G	c.(4-6)GAA>GGA	p.E2G	TRIM16_uc002gor.1_Intron	NM_006382	NP_006373	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	2											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		TTCCAGGTTTTCCATGATCCT	0.498		NA											10	486					0	0	0	0
SEBOX	645832	broad.mit.edu	37	17	26691847	26691847	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:26691847C>T	uc010wai.1	-	2	254	c.240G>A	c.(238-240)TGG>TGA	p.W80*	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_Nonsense_Mutation_p.W79*|SARM1_uc010waj.1_Intron	NM_001080837	NP_001074306	Q9HB31	SEBOX_HUMAN	SEBOX homeobox isoform 1	80	Homeobox.				cell differentiation|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GGCAAGTGACCCAGGCCAGGT	0.607		NA											4	53					0	0	0	0
FOXN1	8456	broad.mit.edu	37	17	26862068	26862068	+	Silent	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:26862068G>T	uc010crm.2	+	8	1677	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L	FOXN1_uc002hbj.2_Silent_p.L493L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	493					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					ACTCGCCTCTGCCTGCCCACA	0.692		NA											25	68					1.18e-14	1.51e-14	1	0
SLFN13	146857	broad.mit.edu	37	17	33767957	33767957	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:33767957G>T	uc002hjk.1	-	4	2681	c.2351C>A	c.(2350-2352)ACT>AAT	p.T784N	SLFN13_uc010wch.1_Missense_Mutation_p.T784N|SLFN13_uc002hjl.2_Missense_Mutation_p.T784N|SLFN13_uc010ctt.2_Missense_Mutation_p.T466N|SLFN13_uc002hjm.2_Missense_Mutation_p.T453N	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	784						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTGCTCCAAAGTAAAGTTTTT	0.443		NA											34	103					1.62e-16	2.09e-16	1	0
TAF15	8148	broad.mit.edu	37	17	34171147	34171147	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:34171147G>T	uc002hkd.2	+	13	1159	c.1073G>T	c.(1072-1074)TGG>TTG	p.W358L	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Missense_Mutation_p.W355L	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	358	RanBP2-type.|Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGTGGGGATTGGGTTTGCCCT	0.527		NA	T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								17	212					1.45e-14	1.85e-14	1	0
GRN	2896	broad.mit.edu	37	17	42428419	42428419	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:42428419C>T	uc002igp.1	+	8	942	c.723C>T	c.(721-723)TCC>TCT	p.S241S	GRN_uc002igr.1_Silent_p.S35S	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	241					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCTGCTGCTCCGATCACCTGC	0.607		NA									OREG0024459	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	116					0	0	0	0
HOXB1	3211	broad.mit.edu	37	17	46607812	46607812	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:46607812A>C	uc002ink.1	-	1	461	c.455T>G	c.(454-456)TTT>TGT	p.F152C		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	152						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCCGGTGCAAAGCTCGCGGT	0.622		NA											9	85					0	0	0	0
HOXB6	3216	broad.mit.edu	37	17	46673816	46673816	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:46673816G>A	uc002ins.1	-	4	959	c.634C>T	c.(634-636)CAG>TAG	p.Q212*	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Nonsense_Mutation_p.Q212*|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	212					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCACTGAGCTGAGACGCGCTG	0.602		NA											7	391					0	0	0	0
CSHL1	1444	broad.mit.edu	37	17	61987866	61987866	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:61987866A>C	uc002jda.1	-	3	282	c.220T>G	c.(220-222)TCA>GCA	p.S74A	CSHL1_uc002jcz.1_Intron|CSHL1_uc002jdb.1_Translation_Start_Site|CSHL1_uc002jdc.1_Intron|CSHL1_uc002jdd.1_Intron|CSHL1_uc002jde.2_Missense_Mutation_p.I171M|CSHL1_uc002jdf.2_Intron|CSHL1_uc002jdg.2_Missense_Mutation_p.I143M|CSHL1_uc002jdh.2_Translation_Start_Site	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	74						extracellular region	hormone activity|metal ion binding				0						TGCAGGAATGAATACTTCTGT	0.507		NA											15	248					0	0	0	0
ERN1	2081	broad.mit.edu	37	17	62144284	62144284	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:62144284G>C	uc002jdz.2	-	8	702	c.589C>G	c.(589-591)CAC>GAC	p.H197D		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	197	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						GACACAAAGTGGGACATCTCT	0.502		NA											3	39					0	0	0	0
ZNF519	162655	broad.mit.edu	37	18	14105333	14105333	+	Silent	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:14105333T>C	uc002kst.1	-	3	1359	c.1206A>G	c.(1204-1206)AAA>AAG	p.K402K	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTTGAAAGGTTTCTCTCCAG	0.403		NA											6	216					0	0	0	0
DSG2	1829	broad.mit.edu	37	18	29110982	29110982	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:29110982C>T	uc002kwu.3	+	9	1235	c.1047C>T	c.(1045-1047)GAC>GAT	p.D349D		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	349	Extracellular (Potential).|Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGAATCTTGACTTCAGTGTTA	0.343		NA											40	110					0	0	0	0
AES	166	broad.mit.edu	37	19	3055690	3055690	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:3055690G>C	uc002lwy.1	-	5	442	c.269C>G	c.(268-270)GCC>GGC	p.A90G	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.A90G|AES_uc002lxa.1_Missense_Mutation_p.A34G|AES_uc002lxb.1_Missense_Mutation_p.A157G|AES_uc002lxc.2_Missense_Mutation_p.A157G	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	90	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACCTGGGCACAAATCCC	0.637		NA											9	114					0	0	0	0
TJP3	27134	broad.mit.edu	37	19	3735583	3735583	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:3735583C>T	uc010xhv.1	+	8	1105	c.1105C>T	c.(1105-1107)CGG>TGG	p.R369W	TJP3_uc010xhs.1_Missense_Mutation_p.R336W|TJP3_uc010xht.1_Missense_Mutation_p.R300W|TJP3_uc010xhu.1_Missense_Mutation_p.R345W|TJP3_uc010xhw.1_Missense_Mutation_p.R355W	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	350						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGCTTCGGCGGGAAAGTTC	0.493		NA											21	206					0	0	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292705	4292705	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:4292705C>A	uc002lzx.1	-	5	786	c.740G>T	c.(739-741)TGC>TTC	p.C247F	TMIGD2_uc010dtv.1_Missense_Mutation_p.C243F	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	247	Pro-rich.|Cytoplasmic (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ggggctggggcagggtctcgg	0.493		NA											7	88					0.00307968	0.00342273	1	0
LRRC8E	80131	broad.mit.edu	37	19	7964965	7964965	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:7964965C>T	uc002mir.2	+	3	1659	c.1558C>T	c.(1558-1560)CAG>TAG	p.Q520*		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	520	LRR 1.					integral to membrane				lung(1)|pancreas(1)	2						GCTTTTCCCCCAGGAGCTAGC	0.657		NA											5	32					0	0	0	0
LASS4	79603	broad.mit.edu	37	19	8321168	8321168	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:8321168C>A	uc002mjg.2	+	7	837	c.517C>A	c.(517-519)CAG>AAG	p.Q173K	LASS4_uc002mjh.2_Missense_Mutation_p.Q122K|LASS4_uc002mji.2_Missense_Mutation_p.Q9K|LASS4_uc010dvz.2_Missense_Mutation_p.Q173K	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	173	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						GTACCCAAACCAGGTGAGTGG	0.572		NA											5	31					3.6e-05	4.21e-05	1	0
ANGPTL4	51129	broad.mit.edu	37	19	8436298	8436298	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:8436298C>A	uc002mjq.1	+	6	1126	c.931C>A	c.(931-933)CAG>AAG	p.Q311K	ANGPTL4_uc002mjr.1_Missense_Mutation_p.Q273K|ANGPTL4_uc010xkc.1_Missense_Mutation_p.Q144K	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	311	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						CGTGGCCGGCCAGCTGGGCGC	0.672		NA											6	55					8.13e-05	9.41e-05	1	0
KEAP1	9817	broad.mit.edu	37	19	10602764	10602764	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:10602764G>A	uc002moq.1	-	3	970	c.814C>T	c.(814-816)CGC>TGC	p.R272C	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.R272C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	272	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GAGTGGCAGCGCACGGCCCGC	0.617		NA											10	60					0	0	0	0
QTRT1	81890	broad.mit.edu	37	19	10822906	10822906	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:10822906T>G	uc002mpr.2	+	6	741	c.716T>G	c.(715-717)TTC>TGC	p.F239C	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	239					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			AAGTCGCAGTTCTGGCGGATG	0.622		NA											10	107					0	0	0	0
DNAJB1	3337	broad.mit.edu	37	19	14627517	14627517	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:14627517T>C	uc002myz.1	-	2	593	c.553A>G	c.(553-555)ATC>GTC	p.I185V	DNAJB1_uc010xnr.1_Missense_Mutation_p.I85V	NM_006145	NP_006136	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	185					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(1328;0.0476)		TTGTGGGAGATTTTCATCTTC	0.502		NA											30	341					0	0	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728598	20728598	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:20728598C>G	uc002npa.2	-	4	591	c.411G>C	c.(409-411)TTG>TTC	p.L137F		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	137					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GAGTAGTTGTCAAATATTGGT	0.299		NA											8	47					0	0	0	0
CCDC123	84902	broad.mit.edu	37	19	33370188	33370188	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:33370188G>A	uc002nty.2	-	19	2321	c.2232C>T	c.(2230-2232)GGC>GGT	p.G744G	CCDC123_uc002ntx.2_Silent_p.G497G|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	744						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TGTCCTGCACGCCTGTCCTCG	0.537		NA											21	255					0	0	0	0
CYP2S1	29785	broad.mit.edu	37	19	41712380	41712380	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:41712380C>G	uc002opw.2	+	9	1557	c.1502C>G	c.(1501-1503)ACG>AGG	p.T501R	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Missense_Mutation_p.T226R	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	501					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						CACTCCACCACGCAGACCAGA	0.602		NA											17	207					0	0	0	0
ZNF229	7772	broad.mit.edu	37	19	44933099	44933099	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:44933099C>A	uc002oze.1	-	6	2291	c.1857G>T	c.(1855-1857)CAG>CAT	p.Q619H	ZNF229_uc010ejk.1_Missense_Mutation_p.Q273H|ZNF229_uc010ejl.1_Missense_Mutation_p.Q613H	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	619	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TGTGGACCCTCTGATGGATAA	0.547		NA											11	156					3.86e-05	4.51e-05	1	0
TTYH1	57348	broad.mit.edu	37	19	54946764	54946764	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:54946764G>A	uc002qfq.2	+	11	1260	c.1168G>A	c.(1168-1170)GAA>AAA	p.E390K	TTYH1_uc010yey.1_Missense_Mutation_p.G420E|TTYH1_uc002qfr.2_Missense_Mutation_p.E390K|TTYH1_uc002qft.2_Missense_Mutation_p.E390K	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	390	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGACGCCCTGGAAGGCCTGCT	0.687		NA											8	87					0	0	0	0
LILRA1	11024	broad.mit.edu	37	19	55105660	55105660	+	Splice_Site	SNP	A	A	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:55105660A>T	uc002qgh.1	+	2	135	c.-47_splice	c.e2-2		LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_5'Flank	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,						cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGTCCTGCCAGCACCGAGGG	0.582		NA											11	94					0	0	0	0
BRSK1	84446	broad.mit.edu	37	19	55815119	55815119	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:55815119G>A	uc002qkg.2	+	12	1488	c.1211G>A	c.(1210-1212)AGC>AAC	p.S404N	BRSK1_uc002qkf.2_Missense_Mutation_p.S420N|BRSK1_uc002qkh.2_Missense_Mutation_p.S99N	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	404					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GAAGTCCTGAGCATCACCGAT	0.662		NA											11	158					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57641043	57641043	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57641043C>A	uc002qny.2	+	4	1356	c.1000C>A	c.(1000-1002)CAG>AAG	p.Q334K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	334					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GACCTTGACCCAGCTGCTTGC	0.378		NA											19	198					7.45e-12	9.4e-12	1	0
ZNF772	400720	broad.mit.edu	37	19	57985605	57985605	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57985605C>T	uc002qot.2	-	5	768	c.507G>A	c.(505-507)CAG>CAA	p.Q169Q	ZNF547_uc002qpm.3_Intron|ZNF772_uc010ygy.1_Silent_p.Q128Q|ZNF772_uc010ygz.1_Silent_p.Q57Q|ZNF772_uc010yha.1_Silent_p.Q115Q|ZNF772_uc002qou.2_Silent_p.Q57Q	NM_001024596	NP_001019767	Q68DY9	ZN772_HUMAN	zinc finger protein 772 isoform 1	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)|Lung(386;0.174)		TGTATGGTTTCTGCCCTGGGT	0.507		NA											12	176					0	0	0	0
ZIK1	284307	broad.mit.edu	37	19	58101682	58101682	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:58101682G>A	uc002qpg.2	+	4	600	c.503G>A	c.(502-504)CGC>CAC	p.R168H	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.R113H|ZIK1_uc002qpi.2_Missense_Mutation_p.R155H|ZIK1_uc002qpj.2_Missense_Mutation_p.R65H	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGCCCTTTCGCAAATGGGAG	0.502		NA											5	81					0	0	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358		NA											2	7					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24432687	24432687	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:24432687C>T	uc002rfe.2	-	35	4731	c.4473G>A	c.(4471-4473)ACG>ACA	p.T1491T	ITSN2_uc002rff.2_Silent_p.T1464T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1491	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATACTCACCGTTTTATACA	0.502		NA											5	108					0	0	0	0
RASGRP3	25780	broad.mit.edu	37	2	33784037	33784037	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:33784037C>T	uc002rox.2	+	18	2631	c.2004C>T	c.(2002-2004)GAC>GAT	p.D668D	RASGRP3_uc010ync.1_Silent_p.D668D|RASGRP3_uc002roy.2_Silent_p.D667D	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	668					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATGTTGTAGACCGGGGCACGG	0.483		NA											9	36					0	0	0	0
RHOQ	23433	broad.mit.edu	37	2	46803235	46803235	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:46803235G>A	uc002rva.2	+	3	530	c.211G>A	c.(211-213)GAC>AAC	p.D71N	uc002rvb.2_Intron	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	71					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGAAGACTATGACCGTCTGAG	0.373		NA											11	113					0	0	0	0
EPCAM	4072	broad.mit.edu	37	2	47602414	47602414	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:47602414C>A	uc002rvx.2	+	4	825	c.467C>A	c.(466-468)CCT>CAT	p.P156H	EPCAM_uc002rvw.2_Missense_Mutation_p.P184H|MIR559_hsa-mir-559|MI0003565_5'Flank	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	156	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						AGAGAAAAACCTTATGATAGT	0.348		NA							Lynch_syndrome				15	56					3.52e-12	4.45e-12	1	0
ACTG2	72	broad.mit.edu	37	2	74129609	74129609	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:74129609G>A	uc002sjw.2	+	3	371	c.249G>A	c.(247-249)ATG>ATA	p.M83I	ACTG2_uc010fex.1_Missense_Mutation_p.M83I|ACTG2_uc010fey.2_Missense_Mutation_p.M83I|ACTG2_uc010yrn.1_Intron	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	83					muscle contraction	cytoskeleton|cytosol	ATP binding				0						GGGATGACATGGAGAAGGTAT	0.453		NA											11	61					0	0	0	0
MGAT4A	11320	broad.mit.edu	37	2	99279521	99279521	+	Silent	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:99279521G>T	uc002sze.2	-	5	839	c.525C>A	c.(523-525)GTC>GTA	p.V175V	MGAT4A_uc010yvm.1_Silent_p.V47V|MGAT4A_uc010fil.2_5'UTR|MGAT4A_uc010fim.1_Silent_p.V47V	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	175	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						CTCCTATGAAGACTACTATAA	0.303		NA											29	268					0.000184323	0.000211827	1	0
LRP1B	53353	broad.mit.edu	37	2	141081587	141081587	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:141081587C>T	uc002tvj.1	-	81	13361	c.12389G>A	c.(12388-12390)GGA>GAA	p.G4130E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4130	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGTCCTGCTCCATATATATA	0.299		NA								TSP Lung(27;0.18)			8	150					0	0	0	0
RIF1	55183	broad.mit.edu	37	2	152324520	152324520	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:152324520C>T	uc002txm.2	+	31	6737	c.6607C>T	c.(6607-6609)CGT>TGT	p.R2203C	RIF1_uc002txl.2_Missense_Mutation_p.R2203C|RIF1_uc002txn.2_Missense_Mutation_p.R2203C|RIF1_uc002txo.2_Missense_Mutation_p.R2203C|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2203	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAGGTTCGCCGTGTCTCCTT	0.358		NA											25	165					0	0	0	0
WIPF1	7456	broad.mit.edu	37	2	175450340	175450340	+	Splice_Site	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:175450340C>T	uc002uiy.2	-	3	295	c.-37_splice	c.e3-1		uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Splice_Site|WIPF1_uc010fqt.1_Splice_Site|WIPF1_uc002ujc.1_Splice_Site|WIPF1_uc002uiz.2_Splice_Site|WIPF1_uc002ujb.1_Splice_Site|WIPF1_uc010zep.1_Splice_Site	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1						actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GCTGATAAATCTGGAAAAACA	0.493		NA											8	57					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179638332	179638332	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:179638332T>G	uc010zfg.1	-	32	7675	c.7451A>C	c.(7450-7452)CAA>CCA	p.Q2484P	TTN_uc010zfh.1_Missense_Mutation_p.Q2438P|TTN_uc010zfi.1_Missense_Mutation_p.Q2438P|TTN_uc010zfj.1_Missense_Mutation_p.Q2438P|TTN_uc002unb.2_Missense_Mutation_p.Q2484P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCTTGATTTGTTCATCATT	0.428		NA											14	185					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179650801	179650801	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:179650801C>G	uc010zfg.1	-	14	2368	c.2144G>C	c.(2143-2145)AGA>ACA	p.R715T	TTN_uc010zfh.1_Missense_Mutation_p.R669T|TTN_uc010zfi.1_Missense_Mutation_p.R669T|TTN_uc010zfj.1_Missense_Mutation_p.R669T|TTN_uc002unb.2_Missense_Mutation_p.R715T|TTN_uc010frg.1_Missense_Mutation_p.R297T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	715							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGGCTCTCTGACTCGGGC	0.502		NA											8	85					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803488	185803488	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:185803488T>A	uc002uph.2	+	4	3959	c.3365T>A	c.(3364-3366)TTT>TAT	p.F1122Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1122						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gcagGAACCTTTAAAGTGCTT	0.348		NA											7	70					0	0	0	0
BTBD3	22903	broad.mit.edu	37	20	11903518	11903518	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:11903518C>A	uc002wnz.2	+	4	1132	c.773C>A	c.(772-774)TCT>TAT	p.S258Y	BTBD3_uc002wny.2_Missense_Mutation_p.S197Y|BTBD3_uc002woa.2_Missense_Mutation_p.S197Y|BTBD3_uc010zrf.1_Missense_Mutation_p.S107Y|BTBD3_uc010zrg.1_Missense_Mutation_p.S107Y|BTBD3_uc010zrh.1_Missense_Mutation_p.S107Y	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	258										ovary(2)|central_nervous_system(1)	3						GCTCTCAAGTCTGAGGGATTC	0.517		NA											13	117					1.5e-05	1.76e-05	1	0
KIF16B	55614	broad.mit.edu	37	20	16359952	16359952	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:16359952C>T	uc002wpg.1	-	19	2853	c.2695G>A	c.(2695-2697)GAG>AAG	p.E899K	KIF16B_uc002wpe.1_Missense_Mutation_p.E281K|KIF16B_uc002wpf.1_Missense_Mutation_p.E281K|KIF16B_uc010gch.1_Missense_Mutation_p.E899K|KIF16B_uc010gci.1_Missense_Mutation_p.E899K|KIF16B_uc010gcj.1_Missense_Mutation_p.E910K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	899	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						AGCCTGTACTCCACTGGCTTT	0.413		NA											16	217					0	0	0	0
ENTPD6	955	broad.mit.edu	37	20	25205950	25205950	+	Silent	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:25205950G>T	uc002wuj.2	+	14	1533	c.1353G>T	c.(1351-1353)CTG>CTT	p.L451L	ENTPD6_uc010zsz.1_Silent_p.L233L|ENTPD6_uc002wum.2_Silent_p.L434L|ENTPD6_uc010zta.1_Nonsense_Mutation_p.E466*|ENTPD6_uc002wun.2_Nonsense_Mutation_p.E432*|ENTPD6_uc002wuk.2_Silent_p.L450L|ENTPD6_uc002wul.2_Nonsense_Mutation_p.E465*|ENTPD6_uc010ztb.1_Nonsense_Mutation_p.E438*|ENTPD6_uc010ztc.1_Silent_p.L423L|ENTPD6_uc002wuo.2_Silent_p.L203L|ENTPD6_uc010ztd.1_Silent_p.L199L|ENTPD6_uc010gdk.1_RNA|ENTPD6_uc010gdl.1_RNA	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	451	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GCAAAGTGCTGAAGGTAAGGG	0.612		NA											9	41					0.000673444	0.000763933	1	0
PTPRT	11122	broad.mit.edu	37	20	40739003	40739003	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:40739003G>A	uc002xkg.2	-	23	3408	c.3224C>T	c.(3223-3225)CCG>CTG	p.P1075L	PTPRT_uc010ggj.2_Missense_Mutation_p.P1094L|PTPRT_uc010ggi.2_Missense_Mutation_p.P278L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1075	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCAGCTTCCGGGGGGTTGAG	0.453		NA											22	72					0	0	0	0
EYA2	2139	broad.mit.edu	37	20	45725801	45725801	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:45725801C>T	uc002xsm.2	+	9	1256	c.882C>T	c.(880-882)TAC>TAT	p.Y294Y	EYA2_uc010ghp.2_Silent_p.Y294Y|EYA2_uc002xsn.2_Silent_p.Y299Y|EYA2_uc002xso.2_Silent_p.Y294Y|EYA2_uc002xsp.2_Silent_p.Y294Y|EYA2_uc002xsq.2_Silent_p.Y294Y	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	294					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				CATCCAGATACGGGAAGGTAA	0.423		NA											29	275					0	0	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296445	28296446	+	Missense_Mutation	DNP	CG	CG	TT	rs75336666		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr21:28296445_28296446CG>TT	uc002ymg.2	-	8	3448_3449	c.2719_2720CG>AA	c.(2719-2721)CGG>AAG	p.R907K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	907	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TGCTAACTTCCGGTTTCCATCC	0.53		NA											13	103					0	0	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380094	30380094	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr21:30380094T>A	uc002yms.2	-	4	800	c.713A>T	c.(712-714)GAA>GTA	p.E238V	RWDD2B_uc002ymt.2_Missense_Mutation_p.E209V|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.E158V	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	238											0						TGACCAGAATTCTTCACAGGC	0.338		NA											37	96					0	0	0	0
SEC14L3	266629	broad.mit.edu	37	22	30858091	30858091	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr22:30858091G>C	uc003ahy.2	-	9	842	c.753C>G	c.(751-753)AAC>AAG	p.N251K	SEC14L3_uc003ahz.2_Missense_Mutation_p.N174K|SEC14L3_uc003aia.2_Missense_Mutation_p.N192K|SEC14L3_uc003aib.2_Missense_Mutation_p.N192K	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	251						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	AACATTTGGGGTTCCCATCTG	0.473		NA											8	37					0	0	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120563	38120563	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr22:38120563T>C	uc003atr.2	+	7	2271	c.2000T>C	c.(1999-2001)ATC>ACC	p.I667T	TRIOBP_uc003atu.2_Missense_Mutation_p.I495T|TRIOBP_uc003atq.1_Missense_Mutation_p.I667T|TRIOBP_uc003ats.1_Missense_Mutation_p.I495T	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	667					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AACAGAACCATCCAACAAGAG	0.572		NA											3	96					0	0	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806357	97806357	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:97806357G>T	uc011bgs.1	+	1	341	c.341G>T	c.(340-342)TGC>TTC	p.C114F		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACTACAGAATGCTTCCTCCTG	0.448		NA											23	380					9.63e-23	1.25e-22	1	0
PRR23A	729627	broad.mit.edu	37	3	138724783	138724783	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:138724783C>T	uc011bms.1	-	1	328	c.328G>A	c.(328-330)GAA>AAA	p.E110K		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	110											0						CCTGAGCGTTCGTCGACAGAG	0.617		NA											6	42					0	0	0	0
HPS3	84343	broad.mit.edu	37	3	148880620	148880620	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:148880620G>C	uc003ewu.1	+	13	2576	c.2436G>C	c.(2434-2436)AAG>AAC	p.K812N	CP_uc011bnr.1_RNA|HPS3_uc011bnq.1_Missense_Mutation_p.K647N|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	812						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GATTGTCTAAGAGGCAGCCTC	0.423		NA							Hermansky-Pudlak_syndrome				22	152					0	0	0	0
DHX36	170506	broad.mit.edu	37	3	154022955	154022955	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:154022955C>T	uc003ezy.3	-	7	977	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	DHX36_uc010hvq.2_Missense_Mutation_p.R299Q|DHX36_uc003ezz.3_Missense_Mutation_p.R299Q	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	299	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CCTTGGCAACCGACTGTGAAT	0.353		NA											4	79					0	0	0	0
NCEH1	57552	broad.mit.edu	37	3	172365794	172365794	+	Silent	SNP	G	G	C	rs141870427	byFrequency	TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:172365794G>C	uc011bpx.1	-	2	483	c.345C>G	c.(343-345)ACC>ACG	p.T115T	NCEH1_uc003fig.2_Silent_p.T115T|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	83	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						AGTCTGTGTCGGTCACCTTCA	0.512		NA											4	124					0	0	0	0
CLCN2	1181	broad.mit.edu	37	3	184071144	184071144	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:184071144C>T	uc003foi.2	-	17	2046	c.1922G>A	c.(1921-1923)AGC>AAC	p.S641N	CLCN2_uc003foh.2_Missense_Mutation_p.S165N|CLCN2_uc010hya.1_Missense_Mutation_p.S624N|CLCN2_uc011brl.1_Missense_Mutation_p.S641N|CLCN2_uc011brm.1_Missense_Mutation_p.S597N	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	641	Cytoplasmic (By similarity).|CBS 1.					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCGGGCTGGGCTCAGCTGGGC	0.627		NA											16	79					0	0	0	0
ATP13A3	79572	broad.mit.edu	37	3	194182898	194182898	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:194182898T>C	uc003fty.3	-	2	424	c.22A>G	c.(22-24)ACC>GCC	p.T8A		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	8					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGATTGATGGTCTTCCTTTCT	0.408		NA											10	138					0	0	0	0
BST1	683	broad.mit.edu	37	4	15716972	15716972	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:15716972A>G	uc003goh.3	+	5	794	c.599A>G	c.(598-600)TAT>TGT	p.Y200C	BST1_uc003goi.2_Missense_Mutation_p.Y11C	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	200					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						ACAGGAGCCTATCCCATCAAA	0.368		NA											13	76					0	0	0	0
UGT2B10	7365	broad.mit.edu	37	4	69885646	69885646	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:69885646A>C	uc011cao.1	-	4	479	c.343T>G	c.(343-345)TAT>GAT	p.Y115D	UGT2B10_uc011can.1_Missense_Mutation_p.Y115D			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	152					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						CAGGGTAAATAAGCATCTGCA	0.378		NA											13	147					0	0	0	0
SULT1E1	6783	broad.mit.edu	37	4	70713474	70713474	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:70713474C>G	uc003heo.2	-	6	646	c.533G>C	c.(532-534)TGG>TCG	p.W178S		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	178					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						CTTTTCCCACCAAGATTTTAC	0.373		NA											50	129					0	0	0	0
GRID2	2895	broad.mit.edu	37	4	94006200	94006200	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:94006200C>T	uc011cdt.1	+	3	557	c.299C>T	c.(298-300)ACG>ATG	p.T100M	GRID2_uc010ikx.2_Missense_Mutation_p.T100M|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	100	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGGCTGCACGTCAGCAGGA	0.522		NA											6	99					0	0	0	0
ADH1B	125	broad.mit.edu	37	4	100232742	100232742	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:100232742C>T	uc003hus.3	-	7	984	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Silent_p.Q260Q|ADH1B_uc011ceh.1_Silent_p.Q145Q|ADH1B_uc011cei.1_Silent_p.Q260Q	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	300					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTGAGAGGTTCTGGGAAGCAG	0.463		NA											19	260					0	0	0	0
TBCK	93627	broad.mit.edu	37	4	107016640	107016640	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:107016640T>A	uc010ilv.2	-	25	2935	c.2570A>T	c.(2569-2571)GAG>GTG	p.E857V	TBCK_uc003hyb.2_Missense_Mutation_p.E600V|TBCK_uc003hye.2_Missense_Mutation_p.E818V|TBCK_uc003hyc.2_Missense_Mutation_p.E794V|TBCK_uc003hyd.2_Missense_Mutation_p.E685V|TBCK_uc003hyf.2_Missense_Mutation_p.E857V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	857	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TATACTTACCTCAGCTGTGTG	0.428		NA											19	90					0	0	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972591	110972591	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:110972591C>A	uc003hzz.2	-	5	827	c.701G>T	c.(700-702)TGG>TTG	p.W234L	ELOVL6_uc003iaa.2_Missense_Mutation_p.W234L	NM_001130721	NP_001124193	Q9H5J4	ELOV6_HUMAN	elongation of very long chain fatty acids-like	234	Helical; (Potential).				fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GAGTGAGGACCAGAAGATGTT	0.473		NA											13	152					0.00185496	0.00207208	1	0
ANK2	287	broad.mit.edu	37	4	114209630	114209630	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:114209630C>T	uc003ibe.3	+	20	2365	c.2265C>T	c.(2263-2265)AAC>AAT	p.N755N	ANK2_uc003ibd.3_Silent_p.N734N|ANK2_uc003ibf.3_Silent_p.N755N|ANK2_uc003ibc.2_Silent_p.N731N|ANK2_uc011cgb.1_Silent_p.N770N	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	755	ANK 22.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAATGTTAACGCAAAAACCA	0.373		NA											15	68					0	0	0	0
USP53	54532	broad.mit.edu	37	4	120190943	120190943	+	Silent	SNP	A	A	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:120190943A>G	uc003ics.3	+	14	2452	c.1386A>G	c.(1384-1386)CAA>CAG	p.Q462Q	USP53_uc003icr.3_Silent_p.Q462Q|USP53_uc003icu.3_Silent_p.Q85Q|USP53_uc003ict.2_Silent_p.Q85Q	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	462					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						TTTCTTCACAAAGGAAAGATT	0.318		NA											9	163					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123147888	123147888	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:123147888G>C	uc003ieh.2	+	22	2865	c.2820G>C	c.(2818-2820)CAG>CAC	p.Q940H	KIAA1109_uc003iei.1_Missense_Mutation_p.Q693H|KIAA1109_uc010ins.1_Missense_Mutation_p.Q283H|KIAA1109_uc003iej.1_3'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	940					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTGGGGACAGACATTTGTTT	0.413		NA											20	294					0	0	0	0
FSTL5	56884	broad.mit.edu	37	4	162307204	162307204	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:162307204A>G	uc003iqh.2	-	16	2675	c.2239T>C	c.(2239-2241)TCC>CCC	p.S747P	FSTL5_uc003iqi.2_Missense_Mutation_p.S746P|FSTL5_uc010iqv.2_Missense_Mutation_p.S737P|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	747						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCAGTAAAGGATGGTTGAAAT	0.408		NA											17	142					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187541443	187541443	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:187541443G>A	uc003izf.2	-	10	6485	c.6297C>T	c.(6295-6297)GTC>GTT	p.V2099V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2099	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATAGCGAATGACATGGCCCA	0.473		NA								HNSCC(5;0.00058)			30	255					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11364871	11364871	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:11364871G>T	uc003jfa.1	-	8	1454	c.1309C>A	c.(1309-1311)CTC>ATC	p.L437I	CTNND2_uc010itt.2_Missense_Mutation_p.L346I|CTNND2_uc011cmy.1_Missense_Mutation_p.L100I|CTNND2_uc011cmz.1_Missense_Mutation_p.L4I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.L4I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	437	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCTGGCTGAGACTCCTCATA	0.627		NA											6	66					4.1e-09	5.07e-09	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576465	33576465	+	Silent	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:33576465G>T	uc003jia.1	-	19	3829	c.3666C>A	c.(3664-3666)CCC>CCA	p.P1222P	ADAMTS12_uc010iuq.1_Silent_p.P1137P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1222	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCCTTTGGCTGGGGAGCAGTC	0.557		NA								HNSCC(64;0.19)			43	140					1.69e-10	2.1e-10	1	0
LIFR	3977	broad.mit.edu	37	5	38510706	38510706	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:38510706T>C	uc010ive.1	-	7	1183	c.851A>G	c.(850-852)CAT>CGT	p.H284R	LIFR_uc003jli.2_Missense_Mutation_p.H284R	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	284	Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GCAGTTTGTATGGCCAATCAG	0.368		NA	T	PLAG1	salivary adenoma								6	117					0	0	0	0
ZNF366	167465	broad.mit.edu	37	5	71756160	71756160	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:71756160C>T	uc003kce.1	-	2	1350	c.1164G>A	c.(1162-1164)CGG>CGA	p.R388R		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGATGGGGCCCCGGTGCGTGG	0.612		NA											8	57					0	0	0	0
PAM	5066	broad.mit.edu	37	5	102363940	102363940	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:102363940G>C	uc003knw.2	+	24	3114	c.2741G>C	c.(2740-2742)AGA>ACA	p.R914T	PAM_uc003kns.2_Missense_Mutation_p.R807T|PAM_uc003knt.2_Missense_Mutation_p.R915T|PAM_uc003knu.2_Missense_Mutation_p.R846T|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Missense_Mutation_p.R816T|PAM_uc003knz.2_Intron	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	914	Cytoplasmic (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GGAAGATTTAGAGGTATGCCT	0.373		NA											22	146					0	0	0	0
MAN2A1	4124	broad.mit.edu	37	5	109153015	109153015	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:109153015C>T	uc003kou.1	+	13	2948	c.1985C>T	c.(1984-1986)TCG>TTG	p.S662L		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	662	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GACCGAATCTCGTTGGTCTCA	0.403		NA											15	183					0	0	0	0
SHROOM1	134549	broad.mit.edu	37	5	132158993	132158993	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:132158993G>A	uc003kxx.2	-	9	2980	c.2175C>T	c.(2173-2175)CGC>CGT	p.R725R	SHROOM1_uc003kxy.1_Silent_p.R725R	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	725	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGCGGCGCACGCGCGCCAGGC	0.692		NA											6	70					0	0	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710445	140710445	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:140710445G>A	uc003lji.1	+	1	194	c.194G>A	c.(193-195)CGC>CAC	p.R65H	PCDHGA1_uc011dan.1_Missense_Mutation_p.R65H	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGAGTCCGCATCGTCTCC	0.592		NA											5	223					0	0	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779873	140779873	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:140779873C>T	uc003lkf.1	+	1	2179	c.2179C>T	c.(2179-2181)CTC>TTC	p.L727F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.L727F|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	727	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAACCTGGTCTCTGTGTCAA	0.567		NA											35	374					0	0	0	0
UBLCP1	134510	broad.mit.edu	37	5	158710239	158710239	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:158710239C>T	uc003lxq.2	+	10	1147	c.821C>T	c.(820-822)GCG>GTG	p.A274V		NM_145049	NP_659486	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase	274	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTATGAAAGCGCACCTAAAT	0.299		NA											16	120					0	0	0	0
GABRA6	2559	broad.mit.edu	37	5	161116008	161116008	+	Silent	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:161116008G>A	uc003lyu.2	+	4	617	c.279G>A	c.(277-279)AAG>AAA	p.K93K	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	93	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGAGGTTGAAGTTTGGGGGGC	0.408		NA								TCGA Ovarian(5;0.080)			15	190					0	0	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310010	178310010	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:178310010C>T	uc003mjl.2	+	5	783	c.557C>T	c.(556-558)TCA>TTA	p.S186L	ZNF354B_uc003mjm.2_Missense_Mutation_p.S186L	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAACTCCATCAAAATGTGAA	0.308		NA											11	87					0	0	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271590	26271590	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:26271590G>A	uc003nhi.2	-	1	23	c.23C>T	c.(22-24)GCA>GTA	p.A8V	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	8					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						GGACTTGCGTGCAGTCTGCTT	0.567		NA											5	66					0	0	0	0
KIFC1	3833	broad.mit.edu	37	6	33371721	33371721	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:33371721C>T	uc003oef.3	+	6	1021	c.571C>T	c.(571-573)CAT>TAT	p.H191Y	KIFC1_uc011drf.1_Missense_Mutation_p.H183Y	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	191	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						ACTGGAGGGGCATTTAGCCAA	0.597		NA											43	170					0	0	0	0
SLC25A27	9481	broad.mit.edu	37	6	46644143	46644143	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:46644143G>A	uc003oyh.2	+	9	1175	c.924G>A	c.(922-924)TGG>TGA	p.W308*	SLC25A27_uc011dwb.1_Intron|SLC25A27_uc003oyg.2_Intron|SLC25A27_uc011dwc.1_Nonsense_Mutation_p.W222*|SLC25A27_uc003oyi.2_Nonsense_Mutation_p.W238*	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	308	Helical; Name=6; (Potential).|Solcar 3.				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			TGGTGTTCTGGCTTACTTATG	0.328		NA											14	96					0	0	0	0
BAG2	9532	broad.mit.edu	37	6	57048922	57048922	+	Silent	SNP	A	A	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:57048922A>G	uc003pdr.2	+	3	962	c.570A>G	c.(568-570)CTA>CTG	p.L190L	BAG2_uc011dxo.1_Silent_p.L157L	NM_004282	NP_004273	O95816	BAG2_HUMAN	BCL2-associated athanogene 2	190					apoptosis|protein folding		protein binding				0	Lung NSC(77;0.126)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CCATCAAGCTATTAGAGCATT	0.363		NA											12	61					0	0	0	0
MOXD1	26002	broad.mit.edu	37	6	132649650	132649650	+	Silent	SNP	G	G	A	rs147693794	byFrequency	TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:132649650G>A	uc003qdf.2	-	5	846	c.747C>T	c.(745-747)AGC>AGT	p.S249S	MOXD1_uc003qde.2_Silent_p.S181S	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	249	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		ACTCCAGAACGCTGTCGTTAA	0.517		NA											10	101					0	0	0	0
ECT2L	345930	broad.mit.edu	37	6	139134477	139134477	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:139134477G>T	uc003qif.1	+	1	169	c.66G>T	c.(64-66)CAG>CAT	p.Q22H	ECT2L_uc011edq.1_5'Flank	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	22					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TAAATAGACAGGTAAGTTACA	0.378		NA											9	93					4.69e-08	5.72e-08	1	0
PLEKHG1	57480	broad.mit.edu	37	6	151089868	151089868	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:151089868T>G	uc003qny.1	+	4	818	c.506T>G	c.(505-507)TTC>TGC	p.F169C	PLEKHG1_uc011eel.1_Missense_Mutation_p.F209C|PLEKHG1_uc011eem.1_Missense_Mutation_p.F228C|PLEKHG1_uc003qnz.2_Missense_Mutation_p.F169C	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	169	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ATCTACCACTTCAATAGGTAA	0.393		NA											7	46					0	0	0	0
PLG	5340	broad.mit.edu	37	6	161139390	161139390	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:161139390C>T	uc003qtm.3	+	8	915	c.852C>T	c.(850-852)CGC>CGT	p.R284R		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	284	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAAACTATCGCGGGAATGTGG	0.493		NA											16	159					0	0	0	0
IKZF1	10320	broad.mit.edu	37	7	50468217	50468217	+	Silent	SNP	C	C	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:50468217C>T	uc003tow.3	+	9	1620	c.1452C>T	c.(1450-1452)CAC>CAT	p.H484H	IKZF1_uc003tox.3_Silent_p.H442H|IKZF1_uc003toy.3_Silent_p.H442H|IKZF1_uc011kck.1_Silent_p.H397H|IKZF1_uc003toz.3_Silent_p.H454H|IKZF1_uc010kyx.2_Silent_p.H224H|IKZF1_uc003tpa.3_Silent_p.H226H	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	484	C2H2-type 5.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TGGGCTGCCACGGCTTCCGTG	0.587		NA	D		ALL								7	26					0	0	0	0
FIGNL1	63979	broad.mit.edu	37	7	50514478	50514478	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:50514478G>C	uc003tpc.2	-	4	885	c.508C>G	c.(508-510)CGA>GGA	p.R170G	FIGNL1_uc003tpb.2_Missense_Mutation_p.R59G|FIGNL1_uc003tpd.2_Missense_Mutation_p.R170G|FIGNL1_uc003tpe.2_Missense_Mutation_p.R170G|FIGNL1_uc010kyy.2_Missense_Mutation_p.R170G	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	170					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GTCCGGTCTCGATCATGAGCT	0.458		NA											35	237					0	0	0	0
AKAP9	10142	broad.mit.edu	37	7	91730273	91730273	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:91730273A>C	uc003ulg.2	+	45	11225	c.11000A>C	c.(10999-11001)AAA>ACA	p.K3667T	AKAP9_uc003ulf.2_Missense_Mutation_p.K3659T|AKAP9_uc003uli.2_Missense_Mutation_p.K3290T|AKAP9_uc003ulj.2_Missense_Mutation_p.K1437T|AKAP9_uc003ull.2_Missense_Mutation_p.K563T	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3671	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAATCTTTGAAAAGGGCAGAG	0.388		NA	T	BRAF	papillary thyroid								18	98					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94038715	94038715	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:94038715G>A	uc003ung.1	+	17	1345	c.874G>A	c.(874-876)GGC>AGC	p.G292S	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	292					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGGCCTCTCCGGCCCCGTTGG	0.498		NA								HNSCC(75;0.22)			7	103					0	0	0	0
SMURF1	57154	broad.mit.edu	37	7	98655145	98655145	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:98655145A>C	uc003upu.1	-	4	553	c.233T>G	c.(232-234)ATT>AGT	p.I78S	SMURF1_uc003upv.1_Missense_Mutation_p.I78S|SMURF1_uc003upt.2_Missense_Mutation_p.I78S	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	78	C2.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CCACACGCTAATGGTTATCGA	0.363		NA											8	57					0	0	0	0
TFEC	22797	broad.mit.edu	37	7	115624314	115624314	+	Splice_Site	SNP	A	A	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:115624314A>G	uc003vhj.1	-	2	364	c.180_splice	c.e2+1	p.H60_splice	TFEC_uc003vhk.1_Splice_Site_p.H60_splice|TFEC_uc003vhl.3_Splice_Site_p.H60_splice|TFEC_uc011kmw.1_Splice_Site_p.H150_splice	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			CATTAGACATACATGCCATTG	0.363		NA											18	229					0	0	0	0
TNPO3	23534	broad.mit.edu	37	7	128655071	128655071	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:128655071C>A	uc003vol.1	-	4	888	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	TNPO3_uc003vom.1_Missense_Mutation_p.D106Y|TNPO3_uc010lly.1_Missense_Mutation_p.D172Y|TNPO3_uc010llz.1_Missense_Mutation_p.D172Y	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	172					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						AAGGCCAAATCTTCTATAATT	0.393		NA											12	118					7.93e-07	9.52e-07	1	0
SNTG1	54212	broad.mit.edu	37	8	51449368	51449368	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:51449368G>T	uc010lxy.1	+	12	1051	c.680G>T	c.(679-681)CGG>CTG	p.R227L	SNTG1_uc003xqs.1_Missense_Mutation_p.R227L|SNTG1_uc010lxz.1_Missense_Mutation_p.R227L|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	227					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GATTTGAGTCGGTGAGTCCGT	0.438		NA											44	279					3.86e-14	4.92e-14	1	0
EYA1	2138	broad.mit.edu	37	8	72184055	72184055	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:72184055T>G	uc003xys.3	-	9	1191	c.904A>C	c.(904-906)AAA>CAA	p.K302Q	EYA1_uc003xyr.3_Missense_Mutation_p.K297Q|EYA1_uc003xyt.3_Missense_Mutation_p.K269Q|EYA1_uc010lzf.2_Missense_Mutation_p.K229Q|EYA1_uc003xyu.2_Missense_Mutation_p.K302Q|EYA1_uc011lfe.1_Missense_Mutation_p.K296Q|EYA1_uc003xyv.2_Missense_Mutation_p.K180Q	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	302					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCACGTGATTTCCCATCTGAA	0.468		NA											33	419					0	0	0	0
MTERFD1	51001	broad.mit.edu	37	8	97251890	97251890	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:97251890C>G	uc003yhs.1	-	8	1161	c.1083G>C	c.(1081-1083)AAG>AAC	p.K361N	MTERFD1_uc003yhr.1_Missense_Mutation_p.K240N|MTERFD1_uc010mbd.1_3'UTR	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	361					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					TTTCTTTGACCTTAAACAGCC	0.323		NA											15	91					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110445377	110445377	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:110445377G>T	uc003yne.2	+	28	3376	c.3272G>T	c.(3271-3273)GGA>GTA	p.G1091V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1091	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGGGTTCTGGATTTTCTCCT	0.333		NA								HNSCC(38;0.096)			35	497					9.63e-15	1.24e-14	1	0
EPPK1	83481	broad.mit.edu	37	8	144944117	144944117	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:144944117C>A	uc003zaa.1	-	1	3318	c.3305G>T	c.(3304-3306)TGC>TTC	p.C1102F		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1102						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATCCCTGGGGCACTCCTCCAG	0.657		NA											12	19					2.27e-07	2.75e-07	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	15					0	0	0	0
PTCH1	5727	broad.mit.edu	37	9	98238315	98238315	+	Splice_Site	SNP	C	C	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:98238315C>A	uc004avk.3	-	12	1916	c.1728_splice	c.e12+1	p.Q576_splice	PTCH1_uc010mro.2_Splice_Site_p.Q425_splice|PTCH1_uc010mrp.2_Splice_Site_p.Q425_splice|PTCH1_uc010mrq.2_Splice_Site_p.Q425_splice|PTCH1_uc004avl.3_Splice_Site_p.Q425_splice|PTCH1_uc010mrr.2_Splice_Site_p.Q510_splice|PTCH1_uc004avm.3_Splice_Site_p.Q575_splice|PTCH1_uc010mrs.1_Splice_Site_p.Q244_splice	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L						embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CAGAAGCTCACCTGGAGGGAG	0.567		NA							Basal_Cell_Nevus_syndrome				24	41					2.42e-17	3.13e-17	1	0
ASTN2	23245	broad.mit.edu	37	9	119976896	119976896	+	Silent	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:119976896G>T	uc004bjs.1	-	3	857	c.756C>A	c.(754-756)ATC>ATA	p.I252I	ASTN2_uc004bjr.1_Silent_p.I252I|ASTN2_uc004bjt.1_Silent_p.I252I	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	252	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGATGTAGTGGATCTCATGAG	0.627		NA											34	44					1.07e-15	1.37e-15	1	0
OR1Q1	158131	broad.mit.edu	37	9	125377720	125377720	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:125377720G>T	uc011lyy.1	+	1	704	c.704G>T	c.(703-705)TGG>TTG	p.W235L		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAGGGCAGGTGGAAAACCTTT	0.557		NA											48	165					1.81e-26	2.37e-26	1	0
P2RY10	27334	broad.mit.edu	37	X	78216634	78216634	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chrX:78216634G>T	uc004ede.2	+	4	986	c.617G>T	c.(616-618)GGA>GTA	p.G206V	P2RY10_uc004edf.2_Missense_Mutation_p.G206V	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GAGCTTGCAGGATTTGTGATC	0.458		NA											10	56					3.07e-06	3.63e-06	1	0
SLC10A3	8273	broad.mit.edu	37	X	153716765	153716765	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chrX:153716765G>A	uc004flq.2	-	3	779	c.515C>T	c.(514-516)CCT>CTT	p.P172L	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.P143L|SLC10A3_uc004flp.2_Missense_Mutation_p.P172L	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	172					organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTCTTCAGCAGGTGAGACCTT	0.602		NA											53	67					0	0	0	0
USP5	8078	broad.mit.edu	37	12	6972476	6972481	+	In_Frame_Del	DEL	GCCTTG	GCCTTG	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:6972476_6972481delGCCTTG	uc001qri.3	+	15	1948_1953	c.1889_1894delGCCTTG	c.(1888-1896)AGCCTTGGT>AGT	p.LG631del	USP5_uc001qrh.3_Intron	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	631_632					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CCCAAAGGTAGCCTTGGTTTCTATGG	0.587		NA											22	186	---	---	---	---	NA	NA	NA	NA
CCDC64	92558	broad.mit.edu	37	12	120527826	120527826	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:120527826delA	uc001txl.1	+	8	1536	c.1511delA	c.(1510-1512)GATfs	p.D504fs	CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Frame_Shift_Del_p.D175fs|CCDC64_uc010szf.1_Frame_Shift_Del_p.D201fs	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	504	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGTTGCTGGATGCCATTCAG	0.532		NA											34	126	---	---	---	---	NA	NA	NA	NA
VPS13C	54832	broad.mit.edu	37	15	62254687	62254701	+	In_Frame_Del	DEL	ATACAAATCCAAATT	ATACAAATCCAAATT	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:62254687_62254701delATACAAATCCAAATT	uc002agz.2	-	34	3546_3560	c.3472_3486delAATTTGGATTTGTAT	c.(3472-3486)AATTTGGATTTGTATdel	p.NLDLY1158del	VPS13C_uc002aha.2_In_Frame_Del_p.NLDLY1115del|VPS13C_uc002ahb.1_In_Frame_Del_p.NLDLY1158del|VPS13C_uc002ahc.1_In_Frame_Del_p.NLDLY1115del	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1158_1162					protein localization					ovary(2)	2						TAGCATCTGGATACAAATCCAAATTAAAACGGAAA	0.367		NA											22	322	---	---	---	---	NA	NA	NA	NA
ALPK2	115701	broad.mit.edu	37	18	56278955	56278955	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:56278955delC	uc002lhj.3	-	2	289	c.75delG	c.(73-75)GAGfs	p.E25fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	25	Ig-like 1.						ATP binding|protein serine/threonine kinase activity	p.E25K(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CGTCTGACTTCTCAGGAACCT	0.483		NA											19	207	---	---	---	---	NA	NA	NA	NA
PEG3	5178	broad.mit.edu	37	19	57325826	57325835	+	Frame_Shift_Del	DEL	AGCTCCTTTG	AGCTCCTTTG	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57325826_57325835delAGCTCCTTTG	uc002qnu.2	-	7	4326_4335	c.3975_3984delCAAAGGAGCT	c.(3973-3984)CTCAAAGGAGCTfs	p.L1325fs	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Frame_Shift_Del_p.L1296fs|PEG3_uc002qnv.2_Frame_Shift_Del_p.L1325fs|PEG3_uc002qnw.2_Frame_Shift_Del_p.L1201fs|PEG3_uc002qnx.2_Frame_Shift_Del_p.L1199fs|PEG3_uc010etr.2_Frame_Shift_Del_p.L1325fs	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1325_1328					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGAATGGTATAGCTCCTTTGAGGGGCTCAG	0.429		NA											8	142	---	---	---	---	NA	NA	NA	NA
ZNF337	26152	broad.mit.edu	37	20	25666234	25666234	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:25666234delT	uc002wva.2	-	3	741	c.219delA	c.(217-219)GAAfs	p.E73fs	ZNF337_uc010ztg.1_Intron|ZNF337_uc002wvb.2_Frame_Shift_Del_p.E73fs|ZNF337_uc002wvc.2_Frame_Shift_Del_p.E73fs	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCTTCTCTCTTCTCCCCAGG	0.572		NA											90	507	---	---	---	---	NA	NA	NA	NA
RNF123	63891	broad.mit.edu	37	3	49758486	49758487	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:49758486_49758487insA	uc003cxh.2	+	38	3858_3859	c.3772_3773insA	c.(3772-3774)TATfs	p.Y1258fs	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1258	RING-type.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CCCCATCTGCTATGCCCACCCC	0.604		NA											24	124	---	---	---	---	NA	NA	NA	NA
HIST1H2BF	8343	broad.mit.edu	37	6	26199981	26199983	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:26199981_26199983delCTT	uc003ngx.2	+	1	195_197	c.195_197delCTT	c.(193-198)TCCTTC>TCC	p.F66del	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	66					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				TCATGAACTCCTTCGTCAACGAT	0.581		NA											40	362	---	---	---	---	NA	NA	NA	NA
SPDYE6	729597	broad.mit.edu	37	7	101989051	101989052	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:101989051_101989052insT	uc011kkp.1	-	6	1242_1243	c.821_822insA	c.(820-822)TATfs	p.Y274fs	SPDYE6_uc003uzb.2_Frame_Shift_Ins_p.Y130fs	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	274											0						GGTTCTTCCTATACAGGAAGTG	0.545		NA											43	685	---	---	---	---	NA	NA	NA	NA
