Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KIAA2013	90231	broad.mit.edu	37	1	11985515	11985515	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:11985515G>A	uc001atk.2	-	1	974	c.780C>T	c.(778-780)CAC>CAT	p.H260H	KIAA2013_uc001atl.1_Silent_p.H260H	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	260	Extracellular (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCACCAGGTGCACCAACC	0.647		NA											10	41					0	0	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22141157	22141157	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:22141157G>A	uc001bfg.1	+	2	539	c.352G>A	c.(352-354)GGC>AGC	p.G118S		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	118	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		GTTCTACGAgggcccgccggg	0.622		NA											4	16					0	0	0	0
SFRS4	6429	broad.mit.edu	37	1	29475301	29475301	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:29475301C>T	uc001bro.2	-	6	1479	c.1106G>A	c.(1105-1107)CGC>CAC	p.R369H	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	369	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		gctgcggctgcgactgcgact	0.09		NA											5	41					0	0	0	0
MFSD2A	84879	broad.mit.edu	37	1	40434298	40434298	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:40434298G>A	uc001cev.2	+	13	1630	c.1449G>A	c.(1447-1449)CTG>CTA	p.L483L	MFSD2A_uc010ojb.1_Silent_p.L431L|MFSD2A_uc001ceu.2_Silent_p.L470L|MFSD2A_uc010ojc.1_Silent_p.L314L|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_Silent_p.L134L	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	483	Helical; (Potential).				transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						AGTTTACACTGAACATGCTCG	0.567		NA											46	161					0	0	0	0
PIGK	10026	broad.mit.edu	37	1	77588033	77588033	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:77588033T>C	uc001dhk.2	-	10	1043	c.998A>G	c.(997-999)GAC>GGC	p.D333G	PIGK_uc010orj.1_Missense_Mutation_p.D257G|PIGK_uc009wbx.2_Missense_Mutation_p.D239G	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	333	Lumenal (Potential).			Missing: Loss of activity.	attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						ATCCATCTGGTCTTCCTTATA	0.299		NA											23	86					0	0	0	0
GTF2B	2959	broad.mit.edu	37	1	89325684	89325684	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:89325684T>C	uc001dmo.3	-	5	535	c.416A>G	c.(415-417)AAT>AGT	p.N139S		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	139	1				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		GAATAAATTATTTGTTCGATC	0.343		NA											26	184					0	0	0	0
SLC6A17	388662	broad.mit.edu	37	1	110709633	110709633	+	Missense_Mutation	SNP	G	G	A	rs142242142		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:110709633G>A	uc009wfq.2	+	2	543	c.82G>A	c.(82-84)GAG>AAG	p.E28K		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	28	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTGGCCCTCGAGGAGCCTGT	0.617		NA											6	22					0	0	0	0
SYT6	148281	broad.mit.edu	37	1	114680442	114680442	+	Missense_Mutation	SNP	C	C	T	rs139165674	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:114680442C>T	uc001eev.2	-	3	741	c.491G>A	c.(490-492)CGT>CAT	p.R164H		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	249	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAGGATACGCACAATCAG	0.542		NA											14	123					0	0	0	0
BCL9	607	broad.mit.edu	37	1	147096054	147096054	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:147096054T>C	uc001epq.2	+	10	4315	c.3575T>C	c.(3574-3576)CTT>CCT	p.L1192P	BCL9_uc010ozr.1_Missense_Mutation_p.L1106P	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1192	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GATGCAGCACTTTGCAAGCCT	0.627		NA	T	IGH@|IGL@	B-ALL								9	112					0	0	0	0
ATP8B2	57198	broad.mit.edu	37	1	154303598	154303598	+	Silent	SNP	T	T	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:154303598T>A	uc001fey.1	+	4	525	c.336T>A	c.(334-336)GCT>GCA	p.A112A	ATP8B2_uc001few.2_Silent_p.A93A|ATP8B2_uc001fex.2_Silent_p.A126A	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	112	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCATCACAGCTGTTAAAGATG	0.353		NA											32	93					0	0	0	0
DNM3	26052	broad.mit.edu	37	1	171956930	171956930	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:171956930G>T	uc001gie.2	+	3	546	c.370G>T	c.(370-372)GTC>TTC	p.V124F	DNM3_uc001gid.3_Missense_Mutation_p.V124F|DNM3_uc009wwb.2_Missense_Mutation_p.V124F|DNM3_uc001gif.2_Missense_Mutation_p.V124F	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	124					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TAATTTACGAGTCTATTCCCC	0.333		NA											14	188					6.32e-08	6.95e-08	1	0
USH2A	7399	broad.mit.edu	37	1	216496972	216496972	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:216496972G>A	uc001hku.1	-	8	1781	c.1394C>T	c.(1393-1395)CCT>CTT	p.P465L	USH2A_uc001hkv.2_Missense_Mutation_p.P465L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	465	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTGTATCCAGGACGATAATT	0.378		NA								HNSCC(13;0.011)			16	172					0	0	0	0
TRIM58	25893	broad.mit.edu	37	1	248028043	248028043	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:248028043G>C	uc001ido.2	+	3	601	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	185						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTTCAGATTGGAGTTTGAGAA	0.602		NA											13	66					0	0	0	0
ANK3	288	broad.mit.edu	37	10	61840373	61840373	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:61840373C>G	uc001jky.2	-	36	4546	c.4354G>C	c.(4354-4356)GAG>CAG	p.E1452Q	ANK3_uc001jkw.2_Missense_Mutation_p.E577Q|ANK3_uc009xpa.2_Missense_Mutation_p.E577Q|ANK3_uc001jkx.2_Missense_Mutation_p.E621Q|ANK3_uc010qih.1_Missense_Mutation_p.E1444Q|ANK3_uc001jkz.3_Missense_Mutation_p.E1437Q|ANK3_uc001jla.1_Missense_Mutation_p.E509Q|ANK3_uc001jkv.2_5'UTR|ANK3_uc009xpb.1_5'Flank|ANK3_uc009xpc.1_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1452					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCTGTTTTCTCAATCTGAAAA	0.383		NA											7	30					0	0	0	0
LRRTM3	347731	broad.mit.edu	37	10	68688015	68688015	+	Silent	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:68688015G>C	uc001jmz.1	+	2	1891	c.1341G>C	c.(1339-1341)GCG>GCC	p.A447A	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.A447A	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	447	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGTACCCTGCGAGCATGAAGC	0.522		NA											17	113					0	0	0	0
KIAA1274	27143	broad.mit.edu	37	10	72298066	72298066	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:72298066C>T	uc001jrd.3	+	12	1635	c.1354C>T	c.(1354-1356)CGC>TGC	p.R452C	KIAA1274_uc001jre.3_5'Flank	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	452										ovary(2)|central_nervous_system(1)	3						CAGTTTCAGCCGCTGGCTGTG	0.667		NA											5	63					0	0	0	0
HPS1	3257	broad.mit.edu	37	10	100202886	100202886	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:100202886C>T	uc010qpf.1	-	3	358	c.112G>A	c.(112-114)GAA>AAA	p.E38K	HPS1_uc001kpi.1_Missense_Mutation_p.E38K|HPS1_uc001kpk.1_Missense_Mutation_p.E38K|HPS1_uc009xwb.2_RNA|HPS1_uc010qph.1_Missense_Mutation_p.E38K|HPS1_uc001kpl.2_Missense_Mutation_p.E38K|HPS1_uc001kpm.1_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	38	Poly-Glu.				lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CTCACCTCTTCTTCCTCATTC	0.557		NA							Hermansky-Pudlak_syndrome				53	193					0	0	0	0
C10orf137	26098	broad.mit.edu	37	10	127412503	127412503	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:127412503C>T	uc001liq.1	+	4	801	c.508C>T	c.(508-510)CAG>TAG	p.Q170*	C10orf137_uc001lin.2_Nonsense_Mutation_p.Q170*|C10orf137_uc001lio.1_Nonsense_Mutation_p.Q170*|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGATCGTCTCAGGTAATGCT	0.398		NA											21	129					0	0	0	0
OR51F1	256892	broad.mit.edu	37	11	4790981	4790981	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:4790981C>G	uc010qyl.1	-	1	167	c.167G>C	c.(166-168)AGT>ACT	p.S56T		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	56						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCATGGAGACTCTGCTGGGT	0.453		NA											8	41					0	0	0	0
OR52N4	390072	broad.mit.edu	37	11	5776889	5776889	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:5776889A>T	uc001mbu.2	+	1	967	c.919A>T	c.(919-921)ATA>TTA	p.I307L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		AGACTGTGTCATAAGGATCCT	0.413		NA											39	93					0	0	0	0
BBOX1	8424	broad.mit.edu	37	11	27148982	27148982	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:27148982G>T	uc001mre.1	+	9	1514	c.1146G>T	c.(1144-1146)AGG>AGT	p.R382S	BBOX1_uc009yih.1_Missense_Mutation_p.R382S|BBOX1_uc001mrg.1_Missense_Mutation_p.R382S	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	382					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TAAGGCAGAGGGTGGAGAATG	0.418		NA											5	113					0.000602214	0.000639301	1	0
FBXO3	26273	broad.mit.edu	37	11	33772131	33772131	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:33772131G>C	uc001muz.2	-	8	914	c.886C>G	c.(886-888)CTT>GTT	p.L296V	FBXO3_uc010rej.1_5'UTR|FBXO3_uc001muy.2_Missense_Mutation_p.L183V|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Missense_Mutation_p.L296V|FBXO3_uc001mvb.1_Missense_Mutation_p.L291V|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	296	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		ACAGAGCTAAGTTCTGGCAGA	0.388		NA											6	71					0	0	0	0
CATSPER1	117144	broad.mit.edu	37	11	65792843	65792843	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:65792843G>A	uc001ogt.2	-	1	1146	c.1008C>T	c.(1006-1008)CAC>CAT	p.H336H		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	336	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						CGGGGGCATCGTGAATCAGGC	0.562		NA											17	106					0	0	0	0
NADSYN1	55191	broad.mit.edu	37	11	71185569	71185569	+	Silent	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:71185569C>T	uc001oqn.2	+	9	921	c.795C>T	c.(793-795)GAC>GAT	p.D265D	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_Translation_Start_Site	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	265	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTCTGGATGACGTGGTAATGA	0.597		NA											21	318					0	0	0	0
UCP3	7352	broad.mit.edu	37	11	73717337	73717337	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:73717337C>G	uc001our.2	-	3	569	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	UCP3_uc001ous.2_Missense_Mutation_p.E72Q	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	72	Solcar 1.				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					CAGGGACCCTCAGTCCGCACC	0.652		NA											6	20					0	0	0	0
CD163L1	283316	broad.mit.edu	37	12	7527092	7527092	+	Missense_Mutation	SNP	C	C	T	rs149805278		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:7527092C>T	uc001qsy.2	-	13	3381	c.3355G>A	c.(3355-3357)GGC>AGC	p.G1119S	CD163L1_uc010sge.1_Missense_Mutation_p.G1129S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1119	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCCCCCAGCCGCGGGAAGGG	0.617		NA											20	97					0	0	0	0
CASC1	55259	broad.mit.edu	37	12	25308247	25308247	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:25308247G>A	uc001rgl.2	-	4	362	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	CASC1_uc001rgk.2_Nonsense_Mutation_p.Q100*|CASC1_uc001rgm.3_Nonsense_Mutation_p.Q158*|CASC1_uc001rgj.2_Nonsense_Mutation_p.Q54*|CASC1_uc010sje.1_Nonsense_Mutation_p.Q35*|CASC1_uc010sjf.1_5'UTR|CASC1_uc010sjg.1_Nonsense_Mutation_p.Q94*|CASC1_uc010sjh.1_RNA	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	94										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			AGTCCTACCTGAGAAAGCAAT	0.348		NA											16	74					0	0	0	0
KRT72	140807	broad.mit.edu	37	12	52994829	52994829	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:52994829G>A	uc001sar.2	-	1	494	c.408C>T	c.(406-408)TTC>TTT	p.F136F	KRT72_uc001saq.2_Silent_p.F136F|KRT72_uc010sns.1_Silent_p.F136F|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	136	Coil 1A.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		TGAAGGAGGCGAACTTGTTGT	0.537		NA											24	101					0	0	0	0
ITGA5	3678	broad.mit.edu	37	12	54795429	54795429	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:54795429T>A	uc001sga.2	-	23	2395	c.2327A>T	c.(2326-2328)CAA>CTA	p.Q776L		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	776	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						CACGTCGCTTTGCGAGTTGTT	0.602		NA											52	172					0	0	0	0
NACA	4666	broad.mit.edu	37	12	57106906	57106906	+	Silent	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:57106906G>C	uc001slz.2	-	6	799	c.450C>G	c.(448-450)GTC>GTG	p.V150V	NACA_uc001sly.2_Silent_p.V150V|NACA_uc009zoy.1_Silent_p.V2013V|NACA_uc001smc.2_Silent_p.V150V|NACA_uc001sma.2_Silent_p.V860V|NACA_uc001smb.2_Silent_p.V150V|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	150					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						GAATGTTTGAGACAGCTTCAC	0.403		NA	T	BCL6	NHL								20	118					0	0	0	0
ALX1	8092	broad.mit.edu	37	12	85680722	85680722	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:85680722A>C	uc001tae.3	+	3	627	c.623A>C	c.(622-624)GAT>GCT	p.D208A		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	208					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		GCCACCTATGATATATCAGTT	0.368		NA											37	104					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104067694	104067694	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:104067694G>A	uc001tjw.2	+	23	2567	c.2381G>A	c.(2380-2382)TGC>TAC	p.C794Y		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	794	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GAATGCCTGTGCGTTCACGGA	0.587		NA											7	57					0	0	0	0
TFDP1	7027	broad.mit.edu	37	13	114285981	114285981	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr13:114285981T>C	uc001vtw.2	+	5	442	c.230T>C	c.(229-231)GTG>GCG	p.V77A	TFDP1_uc010tkd.1_Intron|TFDP1_uc010tke.1_Intron|TFDP1_uc001vty.3_Missense_Mutation_p.V77A|TFDP1_uc001vtx.2_5'Flank|TFDP1_uc010agx.2_Missense_Mutation_p.V77A	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	77					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			AACACCCTGGTGGTAGGAAGC	0.592		NA								TSP Lung(29;0.18)			23	79					0	0	0	0
NIN	51199	broad.mit.edu	37	14	51228570	51228570	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr14:51228570C>G	uc001wym.2	-	16	2025	c.1834G>C	c.(1834-1836)GAA>CAA	p.E612Q	NIN_uc001wyi.2_Missense_Mutation_p.E612Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.E612Q|NIN_uc010tqp.1_Missense_Mutation_p.E618Q|NIN_uc001wyo.2_Missense_Mutation_p.E612Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	612					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TTCATCTGTTCAATGACCAGC	0.438		NA	T	PDGFRB	MPD								57	329					0	0	0	0
GTF2A1	2957	broad.mit.edu	37	14	81670382	81670382	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr14:81670382G>C	uc001xvf.1	-	3	631	c.199C>G	c.(199-201)CTA>GTA	p.L67V	GTF2A1_uc010atb.1_Missense_Mutation_p.L17V|GTF2A1_uc001xvg.1_Missense_Mutation_p.L28V|GTF2A1_uc001xvh.1_Missense_Mutation_p.L28V|SNORA79_uc001xvi.1_5'Flank	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	67					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)		acttgcagtagaagctgctgc	0.204		NA											32	89					0	0	0	0
OR4N4	283694	broad.mit.edu	37	15	22383148	22383148	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:22383148C>T	uc001yuc.1	+	7	1657	c.676C>T	c.(676-678)CGT>TGT	p.R226C	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.R226C	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTGCCATGTTCGTAGGGCAGC	0.483		NA											24	321					0	0	0	0
SNRPN	6638	broad.mit.edu	37	15	25223367	25223367	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:25223367G>C	uc001ywp.1	+	12	1477	c.587G>C	c.(586-588)AGA>ACA	p.R196T	SNRPN_uc001ywq.1_Missense_Mutation_p.R196T|SNRPN_uc001ywr.1_Missense_Mutation_p.R196T|SNRPN_uc001yws.1_Missense_Mutation_p.R196T|SNRPN_uc001ywt.1_Missense_Mutation_p.R196T|SNRPN_uc001ywv.1_Missense_Mutation_p.R199T|SNRPN_uc001yww.1_Missense_Mutation_p.R196T|SNRPN_uc001ywx.1_Missense_Mutation_p.R196T|SNRPN_uc001ywz.1_RNA|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	196	Repeat-rich region.|				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CCTGGTATGAGACCACCCATG	0.507		NA							Prader-Willi_syndrome				23	249					0	0	0	0
NEDD4	4734	broad.mit.edu	37	15	56132818	56132818	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:56132818C>T	uc002adj.2	-	16	3503	c.3203G>A	c.(3202-3204)GGC>GAC	p.G1068D	NEDD4_uc002adl.2_Missense_Mutation_p.G649D|NEDD4_uc002adi.2_Missense_Mutation_p.G996D|NEDD4_uc010ugj.1_Missense_Mutation_p.G1052D|NEDD4_uc010bfm.2_Missense_Mutation_p.G1051D|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1068	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CAACAGTTTGCCATGATAAAC	0.338		NA											5	203					0	0	0	0
SIN3A	25942	broad.mit.edu	37	15	75704051	75704051	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:75704051G>T	uc002bai.2	-	6	1049	c.790C>A	c.(790-792)CAG>AAG	p.Q264K	SIN3A_uc002baj.2_Missense_Mutation_p.Q264K|SIN3A_uc010uml.1_Missense_Mutation_p.Q264K	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	264	Interaction with REST (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GGAGTCTGCTGACTGGCCGGA	0.512		NA											55	193					4.33e-22	5.08e-22	1	0
LINS1	55180	broad.mit.edu	37	15	101120724	101120724	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:101120724G>A	uc002bwe.2	-	3	615	c.324C>T	c.(322-324)ACC>ACT	p.T108T	LINS1_uc002bwf.2_Silent_p.T108T|LINS1_uc002bwg.2_Silent_p.T108T|LINS1_uc002bwh.2_Silent_p.T108T|LINS1_uc010usa.1_Intron|LINS1_uc002bwi.2_Silent_p.T108T	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	108											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			CATGGAACTCGGTTTTGACAG	0.383		NA											11	108					0	0	0	0
SETD1A	9739	broad.mit.edu	37	16	30977267	30977267	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:30977267C>T	uc002ead.1	+	8	2751	c.2065C>T	c.(2065-2067)CGG>TGG	p.R689W		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	689					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GATGTTAACTCGGCTCCATCA	0.617		NA											42	144					0	0	0	0
ZNF267	10308	broad.mit.edu	37	16	31927606	31927606	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:31927606G>A	uc002ecs.3	+	4	2245	c.2036G>A	c.(2035-2037)CGG>CAG	p.R679Q		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	679	C2H2-type 13.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						ACTACACATCGGAGAAGACAT	0.443		NA											7	95					0	0	0	0
ZNF267	10308	broad.mit.edu	37	16	31927613	31927613	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:31927613A>T	uc002ecs.3	+	4	2252	c.2043A>T	c.(2041-2043)AGA>AGT	p.R681S		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	681	C2H2-type 13.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						ATCGGAGAAGACATACTGGAG	0.448		NA											7	94					0	0	0	0
DPEP2	64174	broad.mit.edu	37	16	68021883	68021883	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:68021883G>A	uc010cey.2	-	9	1242	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	DPEP2_uc002evd.3_Nonsense_Mutation_p.Q365*|DPEP2_uc002eve.2_Nonsense_Mutation_p.Q360*|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	360					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TCCAGCCCCTGAGGGAATCTG	0.557		NA											31	120					0	0	0	0
SPEM1	374768	broad.mit.edu	37	17	7324583	7324583	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:7324583G>A	uc002ggv.2	+	3	614	c.589G>A	c.(589-591)GAG>AAG	p.E197K	FGF11_uc010vtw.1_Intron	NM_199339	NP_955371	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	197					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane					0		Prostate(122;0.173)				CATATGGTCCGAGCTGGGCCT	0.637		NA											5	95					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:7578413C>T	uc002gim.2	-	5	711	c.517G>A	c.(517-519)GTG>ATG	p.V173M	TP53_uc002gig.1_Missense_Mutation_p.V173M|TP53_uc002gih.2_Missense_Mutation_p.V173M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41M|TP53_uc010cng.1_Missense_Mutation_p.V41M|TP53_uc002gii.1_Missense_Mutation_p.V41M|TP53_uc010cnh.1_Missense_Mutation_p.V173M|TP53_uc010cni.1_Missense_Mutation_p.V173M|TP53_uc002gij.2_Missense_Mutation_p.V173M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80M|TP53_uc002gio.2_Missense_Mutation_p.V41M|TP53_uc010vug.1_Missense_Mutation_p.V134M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			35	65					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10206726	10206726	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:10206726C>A	uc002gmk.1	-	38	5646	c.5556G>T	c.(5554-5556)AAG>AAT	p.K1852N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1852	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AAGTCATCTCCTTGACTTTGC	0.542		NA											38	279					3.63e-18	4.17e-18	1	0
PIGS	94005	broad.mit.edu	37	17	26885585	26885585	+	Silent	SNP	C	C	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:26885585C>A	uc002hbo.2	-	8	1216	c.843G>T	c.(841-843)GGG>GGT	p.G281G	PIGS_uc002hbn.2_Silent_p.G273G|PIGS_uc010wap.1_Silent_p.G220G	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	281	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GGGGATTCACCCCCAACATTG	0.398		NA											9	23					7.48e-07	8.18e-07	1	0
MYO18A	399687	broad.mit.edu	37	17	27414043	27414043	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:27414043G>A	uc002hdt.1	-	38	5781	c.5623C>T	c.(5623-5625)CGG>TGG	p.R1875W	MYO18A_uc010wbc.1_Missense_Mutation_p.R1408W|MYO18A_uc002hds.2_Missense_Mutation_p.R1417W|MYO18A_uc010csa.1_Missense_Mutation_p.R1838W|MYO18A_uc002hdu.1_Missense_Mutation_p.R1875W	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1875	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CTCTGTAGCCGCTTGTTCTGT	0.612		NA											18	92					0	0	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964713	32964713	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:32964713G>A	uc002hif.2	+	10	2745	c.2417G>A	c.(2416-2418)GGC>GAC	p.G806D		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	806	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCGCTGCTGGGCGTCTTCTGC	0.637		NA											19	120					0	0	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43516996	43516996	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:43516996G>C	uc002ija.2	-	11	3076	c.2906C>G	c.(2905-2907)GCA>GGA	p.A969G	PLEKHM1_uc010wjm.1_Missense_Mutation_p.A941G|PLEKHM1_uc002ijb.2_Missense_Mutation_p.A444G	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	969					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CACCCCGTCTGCGATCTGCGG	0.582		NA											26	69					0	0	0	0
SETBP1	26040	broad.mit.edu	37	18	42533185	42533185	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr18:42533185G>C	uc010dni.2	+	4	4176	c.3880G>C	c.(3880-3882)GAC>CAC	p.D1294H		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1294						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTGGGACAGTGACGTGAGTGG	0.498		NA							Schinzel-Giedion_syndrome				11	80					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63526222	63526222	+	Silent	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr18:63526222C>T	uc002ljz.2	+	9	1759	c.1434C>T	c.(1432-1434)AAC>AAT	p.N478N	CDH7_uc002lka.2_Silent_p.N478N|CDH7_uc002lkb.2_Silent_p.N478N	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	478	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TCAATGATAACGCCCCTGAAT	0.428		NA											7	90					0	0	0	0
ZNF554	115196	broad.mit.edu	37	19	2834412	2834412	+	Silent	SNP	A	A	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:2834412A>T	uc002lwm.2	+	5	1377	c.1179A>T	c.(1177-1179)TCA>TCT	p.S393S	ZNF554_uc002lwl.2_Silent_p.S342S	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	393	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGATCTCATCGCTGACTC	0.532		NA											17	81					0	0	0	0
KANK3	256949	broad.mit.edu	37	19	8387792	8387792	+	Silent	SNP	A	A	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:8387792A>T	uc010dwa.2	-	11	2463	c.2397T>A	c.(2395-2397)CCT>CCA	p.P799P	NDUFA7_uc002mjm.1_5'Flank	NM_198471	NP_940873	Q6NY19	KANK3_HUMAN	ankyrin repeat domain 47	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						TCTGGGAGCCAGGGGGTGACT	0.592		NA											3	50					0	0	0	0
PRKACA	5566	broad.mit.edu	37	19	14217672	14217672	+	Missense_Mutation	SNP	C	C	T	rs56085217		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:14217672C>T	uc002myc.2	-	3	337	c.137G>A	c.(136-138)CGA>CAA	p.R46Q	PRKACA_uc002myb.2_Missense_Mutation_p.R38Q|PRKACA_uc010xnm.1_5'UTR|PRKACA_uc002myd.2_5'UTR	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	46	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						GGTCTTGATTCGTTCAAACTG	0.602		NA											11	113					0	0	0	0
MYO9B	4650	broad.mit.edu	37	19	17305984	17305984	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:17305984C>T	uc010eak.2	+	22	3900	c.3748C>T	c.(3748-3750)CGG>TGG	p.R1250W	MYO9B_uc002nfi.2_Missense_Mutation_p.R1250W|MYO9B_uc002nfj.1_Missense_Mutation_p.R1250W|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1250	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCAGTTGGAGCGGCCGACCAG	0.677		NA											9	21					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606315	21606315	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21606315T>G	uc002npx.2	+	2	750	c.470T>G	c.(469-471)CTA>CGA	p.L157R	ZNF493_uc002npw.2_Missense_Mutation_p.L285R|ZNF493_uc002npy.2_Missense_Mutation_p.L157R	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	157	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGCATAAGCTAATTCATACT	0.343		NA											26	103					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606339	21606339	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21606339A>G	uc002npx.2	+	2	774	c.494A>G	c.(493-495)TAT>TGT	p.Y165C	ZNF493_uc002npw.2_Missense_Mutation_p.Y293C|ZNF493_uc002npy.2_Missense_Mutation_p.Y165C	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	165	C2H2-type 6; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAAACCCTATAAATGTGAA	0.343		NA											25	114					0	0	0	0
ZNF429	353088	broad.mit.edu	37	19	21719595	21719595	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21719595A>G	uc002nqd.1	+	4	877	c.740A>G	c.(739-741)CAT>CGT	p.H247R	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	247	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTTACTAACCATAAGAGAATT	0.383		NA											14	87					0	0	0	0
ZNF100	163227	broad.mit.edu	37	19	21910043	21910043	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21910043G>A	uc002nqi.2	-	5	1270	c.1071C>T	c.(1069-1071)TCC>TCT	p.S357S	ZNF100_uc002nqh.2_Silent_p.S293S	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	357	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGGGTTGAGGACTGGTTAA	0.398		NA											19	179					0	0	0	0
PSG4	5672	broad.mit.edu	37	19	43708353	43708353	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:43708353C>T	uc002ovy.2	-	2	217	c.115G>A	c.(115-117)GAA>AAA	p.E39K	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.E39K|PSG4_uc002ovz.2_Missense_Mutation_p.E39K	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	39	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GGCTGGGCTTCAATCGTGACT	0.458		NA											45	385					0	0	0	0
ZNF221	7638	broad.mit.edu	37	19	44471151	44471151	+	Silent	SNP	C	C	A	rs79157058	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:44471151C>A	uc002oxx.2	+	6	1825	c.1497C>A	c.(1495-1497)CTC>CTA	p.L499L	ZNF221_uc010ejb.1_Silent_p.L499L|ZNF221_uc010xws.1_Silent_p.L499L	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	499	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATCAGAGACTCCACAGTGGGG	0.458		NA											32	129					4.32e-19	4.98e-19	1	0
TMC4	147798	broad.mit.edu	37	19	54664984	54664984	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:54664984G>A	uc010erf.2	-	12	1850	c.1718C>T	c.(1717-1719)TCC>TTC	p.S573F	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.S287F|TMC4_uc002qdo.2_Missense_Mutation_p.S567F	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	573	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGAGCAGGTGGAGAAGAGGGT	0.522		NA											6	28					0	0	0	0
LILRA3	11026	broad.mit.edu	37	19	54803127	54803127	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:54803127C>T	uc002qfd.2	-	4	615	c.550G>A	c.(550-552)GTG>ATG	p.V184M	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	184	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGGGGCCCACGGAGAAGATG	0.567		NA											53	55					0	0	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358		NA											2	6					0	0	0	0
GREB1	9687	broad.mit.edu	37	2	11780421	11780421	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:11780421G>A	uc002rbk.1	+	33	5991	c.5691G>A	c.(5689-5691)GCG>GCA	p.A1897A	GREB1_uc002rbp.1_Silent_p.A895A	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1897						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGCAGGTGCGACGTTGTGTG	0.602		NA											20	58					0	0	0	0
WDR35	57539	broad.mit.edu	37	2	20141576	20141576	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:20141576T>C	uc002rdi.2	-	18	2011	c.1903A>G	c.(1903-1905)ATT>GTT	p.I635V	WDR35_uc002rdj.2_Missense_Mutation_p.I624V|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.I200V|WDR35_uc002rdk.3_Missense_Mutation_p.I200V	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	635										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAATTACAAATATATCCAGAG	0.264		NA											4	19					0	0	0	0
KCNG3	170850	broad.mit.edu	37	2	42671599	42671599	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:42671599G>C	uc002rsn.2	-	2	1382	c.786C>G	c.(784-786)ATC>ATG	p.I262M	KCNG3_uc002rsm.2_Missense_Mutation_p.I251M	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	262	Helical; Name=Segment S3; (Potential).					endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						AATACGGCGTGATTGCCAGTA	0.463		NA											38	107					0	0	0	0
COBLL1	22837	broad.mit.edu	37	2	165551002	165551002	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:165551002T>A	uc010zcw.1	-	15	3339	c.3215A>T	c.(3214-3216)AAT>ATT	p.N1072I	COBLL1_uc002ucp.2_Missense_Mutation_p.N1005I|COBLL1_uc002ucq.2_Missense_Mutation_p.N967I|COBLL1_uc010zcx.1_Missense_Mutation_p.N1013I|COBLL1_uc002ucn.2_Missense_Mutation_p.N433I|COBLL1_uc002uco.2_Missense_Mutation_p.N736I	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	1043										ovary(2)|pancreas(1)	3						AGTCTTCAGATTTTGTGTGGA	0.478		NA											10	76					0	0	0	0
UBR3	130507	broad.mit.edu	37	2	170936487	170936487	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:170936487T>C	uc010zdi.1	+	37	5363	c.5363T>C	c.(5362-5364)CTG>CCG	p.L1788P	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.L609P|UBR3_uc002uft.3_Missense_Mutation_p.L645P|UBR3_uc010zdj.1_Missense_Mutation_p.L479P|UBR3_uc002ufu.3_Missense_Mutation_p.L294P	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1788	Cys-rich.				sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TTTGTATGCCTGAAAGGACTT	0.378		NA											4	221					0	0	0	0
CST4	1472	broad.mit.edu	37	20	23667796	23667796	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr20:23667796G>A	uc002wto.1	-	2	327	c.271C>T	c.(271-273)CGC>TGC	p.R91C		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	91						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CATATGGTGCGGCCCACCTCT	0.572		NA											27	219					0	0	0	0
C22orf36	388886	broad.mit.edu	37	22	24982183	24982183	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr22:24982183G>A	uc003aaq.2	-	4	648	c.619C>T	c.(619-621)CTG>TTG	p.L207L	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	207	LRR 2.										0						AGGCGGGGCAGCGCCCACAGG	0.657		NA											29	82					0	0	0	0
APOBEC3C	27350	broad.mit.edu	37	22	39411612	39411612	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr22:39411612G>A	uc003awr.2	+	2	133	c.30G>A	c.(28-30)AAG>AAA	p.K10K	APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_014508	NP_055323	Q9NRW3	ABC3C_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	10					DNA demethylation|interspecies interaction between organisms|negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|protein binding|zinc ion binding				0	Melanoma(58;0.04)					ACCCGATGAAGGCAATGTATC	0.522		NA											19	157					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73440206	73440206	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:73440206G>A	uc003dpl.1	-	6	1412	c.1316C>T	c.(1315-1317)ACG>ATG	p.T439M	PDZRN3_uc011bgh.1_Missense_Mutation_p.T96M|PDZRN3_uc010hoe.1_Missense_Mutation_p.T137M|PDZRN3_uc011bgf.1_Missense_Mutation_p.T156M|PDZRN3_uc011bgg.1_Missense_Mutation_p.T159M	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	439	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTCATCGTCCGTCCGGTAGCA	0.448		NA											30	308					0	0	0	0
CHST13	166012	broad.mit.edu	37	3	126255198	126255198	+	Splice_Site	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:126255198T>C	uc003eja.2	+	2	180	c.180_splice	c.e2+2	p.Q60_splice		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13						chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		CTGGATCAGGTAGGTGGACAG	0.607		NA											25	90					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907436	164907436	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:164907436G>A	uc003fej.3	-	2	1627	c.1183C>T	c.(1183-1185)CGA>TGA	p.R395*	SLITRK3_uc003fek.2_Nonsense_Mutation_p.R395*	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	395	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TTAAATCCTCGCTCTTTGCAG	0.418		NA								HNSCC(40;0.11)			48	199					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505814	195505814	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:195505814C>T	uc011bto.1	-	3	12713	c.12253G>A	c.(12253-12255)GAC>AAC	p.D4085N	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGTGTCGGTGACAGGA	0.597		NA											3	10					0	0	0	0
PPAT	5471	broad.mit.edu	37	4	57269492	57269492	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:57269492G>A	uc003hbr.2	-	4	680	c.478C>T	c.(478-480)CCT>TCT	p.P160S		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	160	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	TGTTCCTGAGGAGGGGTATAC	0.423		NA											35	131					0	0	0	0
TET2	54790	broad.mit.edu	37	4	106156862	106156862	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:106156862C>A	uc003hxk.2	+	3	2149	c.1763C>A	c.(1762-1764)TCA>TAA	p.S588*	TET2_uc011cez.1_Nonsense_Mutation_p.S609*|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Nonsense_Mutation_p.S588*|TET2_uc003hxi.1_Nonsense_Mutation_p.S588*	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	588					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCACTGCCATCAATTCTTCAG	0.468		NA	Mis N|F		MDS								31	84					2.82e-10	3.16e-10	1	0
NDST4	64579	broad.mit.edu	37	4	115997944	115997944	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:115997944G>A	uc003ibu.2	-	2	928	c.249C>T	c.(247-249)TTC>TTT	p.F83F	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	83	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGCTCTCCACGAAGAGAAGGA	0.433		NA											17	129					0	0	0	0
NDST3	9348	broad.mit.edu	37	4	119035975	119035975	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:119035975G>A	uc003ibx.2	+	4	1487	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	NDST3_uc011cgf.1_Intron	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	362	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TGAAGAGGAAGATGAAGGAGA	0.423		NA											14	87					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247175	153247175	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:153247175T>C	uc003ims.2	-	10	1776	c.1627A>G	c.(1627-1629)AGA>GGA	p.R543G	FBXW7_uc011cii.1_Missense_Mutation_p.R543G|FBXW7_uc003imt.2_Missense_Mutation_p.R543G|FBXW7_uc011cih.1_Missense_Mutation_p.R367G|FBXW7_uc003imq.2_Missense_Mutation_p.R463G|FBXW7_uc003imr.2_Missense_Mutation_p.R425G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	543	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R543K(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GAATAGACTCTATTAGTATGC	0.408		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								39	152					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13883148	13883148	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:13883148G>A	uc003jfd.2	-	20	3081	c.3039C>T	c.(3037-3039)AGC>AGT	p.S1013S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1013	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCAGAGTGACGCTTGCCCGGA	0.478		NA							Kartagener_syndrome				94	172					0	0	0	0
FYB	2533	broad.mit.edu	37	5	39202059	39202060	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:39202059_39202060CC>AG	uc003jls.2	-	1	1070_1071	c.1003_1004GG>CT	c.(1003-1005)GGA>CTA	p.G335L	FYB_uc003jlt.2_Missense_Mutation_p.G335L|FYB_uc003jlu.2_Missense_Mutation_p.G335L|FYB_uc011cpl.1_Missense_Mutation_p.G345L	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	335					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ATTCTTGTCTCCCTTTTCCTTT	0.554		NA											8	95					0	0	0	0
C7	730	broad.mit.edu	37	5	40958326	40958326	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:40958326G>A	uc003jmh.2	+	11	1566	c.1452G>A	c.(1450-1452)GCG>GCA	p.A484A	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	484	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CATTTGGTGCGGCGTGTGAGC	0.502		NA											17	126					0	0	0	0
FTMT	94033	broad.mit.edu	37	5	121187858	121187858	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:121187858G>A	uc003kss.2	+	1	209	c.200G>A	c.(199-201)CGG>CAG	p.R67Q		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	67					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GGCCCCTCTCGGGTGCGCCAG	0.711		NA											7	40					0	0	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723931	140723931	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:140723931G>A	uc003ljm.1	+	1	331	c.331G>A	c.(331-333)GAG>AAG	p.E111K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA3_uc011dap.1_Missense_Mutation_p.E111K	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTCTGGTTGAGGATAAATT	0.403		NA											17	40					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150946563	150946563	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:150946563C>T	uc003lue.3	-	1	1943	c.1930G>A	c.(1930-1932)GAT>AAT	p.D644N	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.D644N	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	644	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTTTGCCATCTGAGGCTGTA	0.418		NA											36	115					0	0	0	0
MAPK9	5601	broad.mit.edu	37	5	179688706	179688706	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:179688706T>A	uc003mls.3	-	5	699	c.428A>T	c.(427-429)CAT>CTT	p.H143L	MAPK9_uc003mlt.3_Missense_Mutation_p.H143L|MAPK9_uc010jlc.2_Missense_Mutation_p.H143L|MAPK9_uc003mlv.3_Missense_Mutation_p.H143L|MAPK9_uc011dgx.1_Missense_Mutation_p.H143L	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	143	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCAGCTGAATGCAGATGTTT	0.308		NA											31	97					0	0	0	0
COL12A1	1303	broad.mit.edu	37	6	75829169	75829169	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:75829169G>A	uc003phs.2	-	45	7273	c.7107C>T	c.(7105-7107)AGC>AGT	p.S2369S	COL12A1_uc003pht.2_Silent_p.S1205S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2369	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TGACCTCATCGCTGTATTGCA	0.433		NA											39	136					0	0	0	0
TXLNB	167838	broad.mit.edu	37	6	139563752	139563752	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:139563752G>A	uc011eds.1	-	10	2131	c.1966C>T	c.(1966-1968)CGA>TGA	p.R656*		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	656						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GCTGCTGCTCGTGGGGGCTGC	0.642		NA											47	93					0	0	0	0
THBS2	7058	broad.mit.edu	37	6	169632834	169632834	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:169632834G>A	uc003qwt.2	-	13	2105	c.1857C>T	c.(1855-1857)TGC>TGT	p.C619C		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	619	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGCAGGGCAGGCAGTGGAAGC	0.637		NA											12	45					0	0	0	0
RBAK	57786	broad.mit.edu	37	7	5105050	5105050	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:5105050G>A	uc010kss.1	+	6	2287	c.1963G>A	c.(1963-1965)GAA>AAA	p.E655K	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E655K	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	655	C2H2-type 15.|Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TGAATGTAATGAATGTGGGAA	0.398		NA											44	191					0	0	0	0
HDAC9	9734	broad.mit.edu	37	7	18767227	18767227	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:18767227C>T	uc003suh.2	+	12	1788	c.1747C>T	c.(1747-1749)CGT>TGT	p.R583C	HDAC9_uc003sue.2_Missense_Mutation_p.R583C|HDAC9_uc011jyd.1_Missense_Mutation_p.R583C|HDAC9_uc003sui.2_Missense_Mutation_p.R586C|HDAC9_uc003suj.2_Missense_Mutation_p.R542C|HDAC9_uc003sua.1_Missense_Mutation_p.R561C|HDAC9_uc010kue.1_Missense_Mutation_p.R238C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	583					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CACGCACACACGTGCGCTCTC	0.547		NA											9	17					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94052391	94052391	+	Silent	SNP	C	C	T	rs41317725		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:94052391C>T	uc003ung.1	+	40	2997	c.2526C>T	c.(2524-2526)TTC>TTT	p.F842F	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	842			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCCTGGCTTCGCTGGTGAGA	0.532		NA								HNSCC(75;0.22)			33	175					0	0	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558424	113558424	+	Missense_Mutation	SNP	G	G	A	rs141223649	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:113558424G>A	uc010ljy.1	-	1	659	c.628C>T	c.(628-630)CGT>TGT	p.R210C		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	210	CBM21.				glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GTTTCATAACGTATACAAAAC	0.348		NA											26	140					0	0	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121676716	121676716	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:121676716A>G	uc003vjy.2	+	18	5742	c.5347A>G	c.(5347-5349)ATC>GTC	p.I1783V	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I916V|PTPRZ1_uc011knt.1_Missense_Mutation_p.I373V	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1783	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GACTGATTATATCAATGCCAA	0.303		NA											23	65					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126410117	126410117	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:126410117G>A	uc003vlr.2	-	6	1470	c.1159C>T	c.(1159-1161)CTG>TTG	p.L387L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.L387L|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Silent_p.L108L	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	387	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ATTCGCTCCAGCCCTGCAAAA	0.378		NA								HNSCC(24;0.065)			19	39					0	0	0	0
ESYT2	57488	broad.mit.edu	37	7	158560437	158560437	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:158560437T>C	uc003wob.1	-	8	1042	c.976A>G	c.(976-978)ATA>GTA	p.I326V	ESYT2_uc003woc.1_Missense_Mutation_p.I150V|ESYT2_uc003wod.1_Missense_Mutation_p.I326V	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	354						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TTTGATATTATATCCAAAATG	0.408		NA											11	78					0	0	0	0
HR	55806	broad.mit.edu	37	8	21976686	21976686	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:21976686C>T	uc003xas.2	-	15	3753	c.3088G>A	c.(3088-3090)GCA>ACA	p.A1030T	HR_uc003xat.2_Missense_Mutation_p.A1030T	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1030	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCTTTCTGTGCCCGGTGCCAG	0.652		NA											3	64					0	0	0	0
C8orf34	116328	broad.mit.edu	37	8	69621297	69621297	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:69621297A>T	uc010lyz.2	+	9	1101	c.1052A>T	c.(1051-1053)AAA>ATA	p.K351I	C8orf34_uc003xyb.2_Missense_Mutation_p.K326I	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	351					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCAGATGAAAAAATCCCAGAT	0.328		NA											28	64					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616422	77616422	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:77616422G>C	uc003yav.2	+	2	486	c.99G>C	c.(97-99)GAG>GAC	p.E33D	ZFHX4_uc003yat.1_Missense_Mutation_p.E33D|ZFHX4_uc003yau.1_Missense_Mutation_p.E33D|ZFHX4_uc003yaw.1_Missense_Mutation_p.E33D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	33						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGTGCCAGAGAAAGTTGCAG	0.502		NA								HNSCC(33;0.089)			16	70					0	0	0	0
C8orf31	286122	broad.mit.edu	37	8	144130635	144130635	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:144130635G>A	uc003yxp.1	+	5	717	c.365G>A	c.(364-366)CGG>CAG	p.R122Q	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_RNA	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	122										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ggattctctcggcaccacggg	0.02		NA											19	130					0	0	0	0
EPPK1	83481	broad.mit.edu	37	8	144940258	144940258	+	Silent	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:144940258G>A	uc003zaa.1	-	2	15187	c.15174C>T	c.(15172-15174)GAC>GAT	p.D5058D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5058	Plectin 65.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCGTGTTGGGGTCGAAGAAGC	0.632		NA											19	527					0	0	0	0
HAUS6	54801	broad.mit.edu	37	9	19058811	19058811	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:19058811G>T	uc003znk.2	-	16	2207	c.1954C>A	c.(1954-1956)CAT>AAT	p.H652N	HAUS6_uc011lmz.1_Missense_Mutation_p.H372N|HAUS6_uc003znl.1_Missense_Mutation_p.H516N	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	652					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TCAGTCAAATGAGACTGGCCA	0.398		NA											47	113					4.01e-20	4.64e-20	1	0
FAM75C1	441452	broad.mit.edu	37	9	90535829	90535829	+	Missense_Mutation	SNP	G	G	A	rs144903965	by1000genomes	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:90535829G>A	uc010mqi.2	+	4	1036	c.1007G>A	c.(1006-1008)GGG>GAG	p.G336E	FAM75C1_uc004apq.3_Missense_Mutation_p.G319E	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TCCCATCTGGGGCCTGAGTCC	0.567		NA											28	265					0	0	0	0
TLR4	7099	broad.mit.edu	37	9	120466838	120466838	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:120466838G>A	uc004bjz.2	+	1	379	c.88G>A	c.(88-90)GTG>ATG	p.V30M	TLR4_uc004bka.2_Translation_Start_Site|TLR4_uc004bkb.2_Translation_Start_Site	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	30	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GGAGCCCTGCGTGGAGGTATG	0.542		NA											21	38					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21609140	21609140	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:21609140G>T	uc004czx.1	+	15	1694	c.1658G>T	c.(1657-1659)GGT>GTT	p.G553V	CNKSR2_uc004czw.2_Missense_Mutation_p.G553V|CNKSR2_uc011mjn.1_Missense_Mutation_p.G504V|CNKSR2_uc011mjo.1_Missense_Mutation_p.G523V|CNKSR2_uc004czy.2_Missense_Mutation_p.G145V	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	553					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CACCCTTTAGGTCCTATAGCA	0.383		NA											51	102					9.16e-17	1.05e-16	1	0
IL1RAPL1	11141	broad.mit.edu	37	X	29417342	29417342	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:29417342G>T	uc004dby.2	+	5	1128	c.620G>T	c.(619-621)AGA>ATA	p.R207I		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	207	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AGAGAAGTCAGAGAAGATGAC	0.338		NA											28	42					1.34e-20	1.56e-20	1	0
KIAA2022	340533	broad.mit.edu	37	X	73962241	73962241	+	Silent	SNP	G	G	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:73962241G>C	uc004eby.2	-	3	2768	c.2151C>G	c.(2149-2151)CTC>CTG	p.L717L		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	717					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TGATTTTATTGAGCACTTTCC	0.418		NA											4	103					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105153047	105153047	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:105153047C>T	uc004emd.2	+	13	1717	c.1414C>T	c.(1414-1416)CGG>TGG	p.R472W	NRK_uc010npc.1_Missense_Mutation_p.R140W	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	472	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TCCACGACTACGGAGGGCAGC	0.557		NA								HNSCC(51;0.14)			10	26					0	0	0	0
CLDN2	9075	broad.mit.edu	37	X	106171511	106171511	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:106171511T>C	uc004emq.1	+	2	572	c.53T>C	c.(52-54)CTT>CCT	p.L18P	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.L18P	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	18	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTTCTGGGGCTTTTGGGCACA	0.562		NA											3	98					0	0	0	0
DDX3Y	8653	broad.mit.edu	37	Y	15025642	15025642	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrY:15025642G>A	uc004fsu.1	+	8	859	c.550G>A	c.(550-552)GAC>AAC	p.D184N	DDX3Y_uc010nwv.1_Missense_Mutation_p.D184N|DDX3Y_uc011naq.1_Missense_Mutation_p.D184N|DDX3Y_uc004fsv.2_Missense_Mutation_p.D184N|DDX3Y_uc010nww.1_5'UTR|DDX3Y_uc011nar.1_Missense_Mutation_p.D181N	NM_001122665	NP_001116137	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3,	184	Q motif.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding				0						TAGCGATATTGACATGGGAGA	0.348		NA											16	83					0	0	0	0
BCAR3	8412	broad.mit.edu	37	1	94033309	94033310	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:94033309_94033310insCA	uc001dpz.2	-	10	2348_2349	c.2073_2074insTG	c.(2071-2076)CTGCATfs	p.L691fs	BCAR3_uc001dqa.2_Frame_Shift_Ins_p.L691fs|BCAR3_uc001dqb.2_Frame_Shift_Ins_p.L691fs|BCAR3_uc001dpx.3_Frame_Shift_Ins_p.L367fs|BCAR3_uc001dpy.2_Frame_Shift_Ins_p.L600fs	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	691_692	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTGCCTTCATGCAGGAGTTTGC	0.535		NA											27	84	---	---	---	---	NA	NA	NA	NA
PHLPP2	23035	broad.mit.edu	37	16	71710362	71710363	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:71710362_71710363insA	uc002fax.2	-	8	1464_1465	c.1458_1459insT	c.(1456-1461)TATGCCfs	p.Y486fs	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Frame_Shift_Ins_p.Y486fs	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	486_487	LRR 11.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TTGGAACTGGCATAGAGGGTCC	0.5		NA											15	58	---	---	---	---	NA	NA	NA	NA
NPEPPS	9520	broad.mit.edu	37	17	45695767	45695768	+	In_Frame_Ins	INS	-	-	TTG			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:45695767_45695768insTTG	uc002ilr.3	+	20	2570_2571	c.2347_2348insTTG	c.(2347-2349)CTT>CTTGTT	p.783_784insV	NPEPPS_uc010wkt.1_In_Frame_Ins_p.779_780insV|NPEPPS_uc010wku.1_In_Frame_Ins_p.747_748insV|NPEPPS_uc010wkv.1_In_Frame_Ins_p.337_338insV|NPEPPS_uc002ils.1_In_Frame_Ins_p.216_217insV	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	783_784					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						CGAAAGAGTCCTTGGCGCTACT	0.391		NA											12	103	---	---	---	---	NA	NA	NA	NA
FPR2	2358	broad.mit.edu	37	19	52272530	52272531	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:52272530_52272531insT	uc002pxr.2	+	2	664_665	c.619_620insT	c.(619-621)GTCfs	p.V207fs	FPR2_uc002pxs.3_Frame_Shift_Ins_p.V207fs|FPR2_uc010epf.2_Frame_Shift_Ins_p.V207fs	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	207	Helical; Name=5; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TATCCGGTTTGTCATTGGCTTT	0.505		NA											37	93	---	---	---	---	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	141459289	141459289	+	Splice_Site	DEL	C	C	-			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:141459289delC	uc002tvj.1	-	40	7399	c.6427_splice	c.e40+1	p.G2143_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAGTGCTGACCTTTCTCTCT	0.348		NA								TSP Lung(27;0.18)			7	116	---	---	---	---	NA	NA	NA	NA
KIF9	64147	broad.mit.edu	37	3	47286984	47287007	+	Splice_Site	DEL	ACTTCCTGTTCCTGTTGGCTTGGG	ACTTCCTGTTCCTGTTGGCTTGGG	-			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:47286984_47287007delACTTCCTGTTCCTGTTGGCTTGGG	uc010hjp.2	-	15	1894	c.1290_splice	c.e15-1	p.S430_splice	KIF9_uc003cqx.2_Splice_Site_p.S430_splice|KIF9_uc003cqy.2_Splice_Site_p.S430_splice|KIF9_uc011bat.1_Splice_Site	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2						blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGTGGACTCCACTTCCTGTTCCTGTTGGCTTGGGAGACAGCAAG	0.509		NA											23	129	---	---	---	---	NA	NA	NA	NA
PBRM1	55193	broad.mit.edu	37	3	52637575	52637576	+	Frame_Shift_Ins	INS	-	-	TTTC			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:52637575_52637576insTTTC	uc003des.2	-	17	2752_2753	c.2740_2741insGAAA	c.(2740-2742)ATAfs	p.I914fs	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc003der.2_Frame_Shift_Ins_p.I882fs|PBRM1_uc003det.2_Frame_Shift_Ins_p.I929fs|PBRM1_uc003deu.2_Frame_Shift_Ins_p.I929fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc010hmk.1_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dey.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dez.1_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dfb.1_Frame_Shift_Ins_p.I827fs|PBRM1_uc003dfa.1_Frame_Shift_Ins_p.I260fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	914					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATCTTCCTCTATTTCTTTTGGC	0.332		NA	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								8	44	---	---	---	---	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187541516	187541516	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:187541516delT	uc003izf.2	-	10	6412	c.6224delA	c.(6223-6225)AATfs	p.N2075fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2075	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CGCATTATCATTTTGGTCTTC	0.498		NA								HNSCC(5;0.00058)			103	212	---	---	---	---	NA	NA	NA	NA
RASA1	5921	broad.mit.edu	37	5	86674262	86674264	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:86674262_86674264delGGA	uc003kiw.2	+	18	2512_2514	c.2394_2396delGGA	c.(2392-2397)ATGGAG>ATG	p.E799del	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_In_Frame_Del_p.E622del|RASA1_uc011ctv.1_In_Frame_Del_p.E632del|RASA1_uc011ctw.1_In_Frame_Del_p.E633del|RASA1_uc010jaw.2_In_Frame_Del_p.E621del	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	799	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCACCTTGATGGAGCAGTATATG	0.369		NA											34	119	---	---	---	---	NA	NA	NA	NA
STK19	8859	broad.mit.edu	37	6	31939825	31939826	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:31939825_31939826insG	uc003nyv.2	+	1	180_181	c.52_53insG	c.(52-54)CGGfs	p.R18fs	DOM3Z_uc003nyo.1_5'UTR|DOM3Z_uc003nyp.1_5'UTR|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_5'UTR|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'UTR|STK19_uc003nyt.2_5'UTR|DOM3Z_uc003nyu.1_5'UTR|STK19_uc011dow.1_Frame_Shift_Ins_p.R18fs|STK19_uc011dox.1_5'UTR|STK19_uc003nyw.2_Frame_Shift_Ins_p.R18fs|STK19_uc010jtn.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	18						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						GCGACAGTGGCGGGCAAACCCC	0.634		NA											11	273	---	---	---	---	NA	NA	NA	NA
