Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
DDI2	84301	broad.mit.edu	37	1	15956839	15956839	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:15956839C>T	uc001awx.1	+	3	384	c.288C>T	c.(286-288)TTC>TTT	p.F96F	DDI2_uc001aww.2_Silent_p.F96F|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	96					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		GAATAGATTTCAGTAGTATAG	0.463		NA											30	56					0	0	0	0
CDC42	998	broad.mit.edu	37	1	22408230	22408230	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:22408230G>A	uc001bfq.2	+	4	413	c.121G>A	c.(121-123)GCA>ACA	p.A41T	CDC42_uc009vqg.1_Missense_Mutation_p.A41T|CDC42_uc001bfp.2_Missense_Mutation_p.A41T|CDC42_uc001bfr.2_Missense_Mutation_p.A41T|CDC42_uc010odr.1_Missense_Mutation_p.A86T|CDC42_uc010ods.1_Missense_Mutation_p.A83T|CDC42_uc009vqh.2_Intron	NM_001039802	NP_001034891	P60953	CDC42_HUMAN	cell division cycle 42 isoform 1	41					actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			haematopoietic_and_lymphoid_tissue(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		TGACAACTATGCAGTCACAGT	0.348		NA											35	63					0	0	0	0
EPHA10	284656	broad.mit.edu	37	1	38227344	38227344	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:38227344C>T	uc009vvi.2	-	3	669	c.583G>A	c.(583-585)GTG>ATG	p.V195M	EPHA10_uc001cbw.3_Missense_Mutation_p.V195M	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	195	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATGCGCCCACGTCCTGAAAG	0.682		NA											18	43					0	0	0	0
GLIS1	148979	broad.mit.edu	37	1	53972293	53972293	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:53972293C>T	uc001cvr.1	-	10	2429	c.1862G>A	c.(1861-1863)TGA>TAA	p.*621*		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	621					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GGGGCTCCTTCAGGTGTCTGT	0.642		NA											20	40					0	0	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161705	57161705	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:57161705A>G	uc001cyk.3	+	6	732	c.661A>G	c.(661-663)ACG>GCG	p.T221A		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	221	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						GCATGTACCTACGTTATTTAA	0.448		NA											137	179					0	0	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049999	90049999	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:90049999T>C	uc001dni.2	+	7	2297	c.1790T>C	c.(1789-1791)CTG>CCG	p.L597P	LRRC8B_uc001dnh.2_Missense_Mutation_p.L597P|LRRC8B_uc001dnj.2_Missense_Mutation_p.L597P	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	597	LRR 6.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		AGCTGTGACCTGGAACGCATC	0.403		NA											3	52					0	0	0	0
NBPF9	400818	broad.mit.edu	37	1	144814712	144814712	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:144814712G>A	uc009wig.1	+	11	1200	c.1124G>A	c.(1123-1125)CGA>CAA	p.R375Q	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.R375Q|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.R306Q|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.R306Q|NBPF9_uc010oyg.1_Missense_Mutation_p.R340Q|NBPF9_uc009wii.1_Missense_Mutation_p.R104Q|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.R35Q	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	375	Potential.					cytoplasm					0						GCTCAGGAACGAGAGCTGACC	0.507		NA											87	129					0	0	0	0
C1orf43	25912	broad.mit.edu	37	1	154179930	154179930	+	Nonstop_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:154179930C>G	uc001fei.2	-	7	1151	c.761G>C	c.(760-762)TGA>TCA	p.*254S	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Nonstop_Mutation_p.*151S|C1orf43_uc001feg.2_Nonstop_Mutation_p.*220S|C1orf43_uc001feh.2_Nonstop_Mutation_p.*202S|C1orf43_uc001fej.2_Nonstop_Mutation_p.*236S|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	254						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					TCAGCTCCGTCACAGAGTACT	0.517		NA											3	159					0	0	0	0
BCAN	63827	broad.mit.edu	37	1	156628471	156628471	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:156628471C>T	uc001fpp.2	+	13	2910	c.2574C>T	c.(2572-2574)TGC>TGT	p.C858C		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	858	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGATCCGATGCCAAGAGAACG	0.627		NA											32	82					0	0	0	0
ASTN1	460	broad.mit.edu	37	1	176833525	176833525	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:176833525G>A	uc001glc.2	-	23	3992	c.3780C>T	c.(3778-3780)CCC>CCT	p.P1260P	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1268					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CAAGTCCGTAGGGTTTGATCT	0.572		NA											31	83					0	0	0	0
KCNH1	3756	broad.mit.edu	37	1	210971026	210971026	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:210971026G>A	uc001hib.2	-	9	1909	c.1739C>T	c.(1738-1740)CCG>CTG	p.P580L	KCNH1_uc001hic.2_Missense_Mutation_p.P553L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	580	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCGGAAGGCCGGGTGCTCCTT	0.607		NA											22	47					0	0	0	0
C10orf140	387640	broad.mit.edu	37	10	21804522	21804522	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:21804522C>G	uc009xkd.2	-	4	4483	c.2230G>C	c.(2230-2232)GAA>CAA	p.E744Q	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	663						nucleus	nucleotide binding			ovary(1)	1						GAAGGAGTTTCTTTTTCAGGG	0.453		NA											80	152					0	0	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332754	71332754	+	Missense_Mutation	SNP	C	C	T	rs146974265		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:71332754C>T	uc001jpp.2	-	2	204	c.46G>A	c.(46-48)GAG>AAG	p.E16K		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	16					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						CGCTCCGTCTCACGGGTCACT	0.677		NA											17	44					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	106982909	106982909	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:106982909G>A	uc001kyi.1	+	20	2997	c.2770G>A	c.(2770-2772)GTT>ATT	p.V924I	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	924	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTTCCATTTGTTGCCATAAG	0.453		NA											25	73					0	0	0	0
SBF2	81846	broad.mit.edu	37	11	10022466	10022466	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:10022466C>G	uc001mib.2	-	8	994	c.856G>C	c.(856-858)GAA>CAA	p.E286Q	SBF2_uc001mif.3_Missense_Mutation_p.E42Q	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	286	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTTACAAGTTCATGGACATCA	0.363		NA											3	6					0	0	0	0
ABTB2	25841	broad.mit.edu	37	11	34194744	34194744	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:34194744C>T	uc001mvl.1	-	4	1027	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	266							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CAGCAGCAGCCGGGCTGCCTG	0.692		NA											13	36					0	0	0	0
TP53I11	9537	broad.mit.edu	37	11	44958408	44958408	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:44958408C>T	uc001myi.2	-	8	885	c.280G>A	c.(280-282)GGA>AGA	p.G94R	TP53I11_uc001myf.1_RNA|TP53I11_uc001myj.2_Missense_Mutation_p.G94R|TP53I11_uc001myk.2_Missense_Mutation_p.G94R|TP53I11_uc001myl.2_Missense_Mutation_p.G94R|TP53I11_uc001mym.2_Missense_Mutation_p.G41R	NM_006034	NP_006025	O14683	P5I11_HUMAN	p53-induced protein	94	Extracellular (Potential).				negative regulation of cell proliferation|response to stress	integral to membrane				ovary(1)	1						ACCTGGGCTCCATCAAAGACC	0.687		NA									OREG0020923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	26					0	0	0	0
C11orf9	745	broad.mit.edu	37	11	61533490	61533490	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:61533490G>A	uc001nsc.1	+	3	291	c.195G>A	c.(193-195)GCG>GCA	p.A65A	C11orf9_uc001nse.1_Silent_p.A56A	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	65					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GGCAGCCTGCGATGCCTGGCT	0.746		NA											5	13					0	0	0	0
PCNXL3	399909	broad.mit.edu	37	11	65402839	65402839	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:65402839C>T	uc001oey.2	+	31	5104	c.5104C>T	c.(5104-5106)CGC>TGC	p.R1702C	PCNXL3_uc001oez.2_Missense_Mutation_p.R589C	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1702						integral to membrane					0						GCTGGCGCTGCGCCATGTCCT	0.637		NA											7	20					0	0	0	0
GAB2	9846	broad.mit.edu	37	11	77937653	77937653	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:77937653G>A	uc001ozh.2	-	4	1065	c.1065C>T	c.(1063-1065)CCC>CCT	p.P355P	GAB2_uc001ozg.2_Silent_p.P317P	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	355	SH3-binding.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTGGCTTGGGGGGGCGGGGTG	0.582		NA											24	53					0	0	0	0
EXPH5	23086	broad.mit.edu	37	11	108385369	108385369	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:108385369G>C	uc001pkk.2	-	6	976	c.865C>G	c.(865-867)CCT>GCT	p.P289A	EXPH5_uc010rvy.1_Missense_Mutation_p.P101A|EXPH5_uc010rvz.1_Missense_Mutation_p.P133A|EXPH5_uc010rwa.1_Missense_Mutation_p.P213A	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	289					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTGTCCTAGGAGAAAAGGTT	0.378		NA											12	30					0	0	0	0
CLEC2D	29121	broad.mit.edu	37	12	9840539	9840539	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:9840539C>T	uc001qwg.1	+	3	236	c.214C>T	c.(214-216)CAA>TAA	p.Q72*	CLEC2D_uc001qwf.1_Nonsense_Mutation_p.Q72*|CLEC2D_uc009zgs.1_RNA|CLEC2D_uc001qwh.1_RNA|CLEC2D_uc009zgt.1_RNA|CLEC2D_uc009zgu.1_Nonsense_Mutation_p.Q30*	NM_013269	NP_037401	Q9UHP7	CLC2D_HUMAN	osteoclast inhibitory lectin isoform 1	72	Extracellular (Potential).				cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0						AGTATGTCTTCAAGCTGCATG	0.303		NA											11	38					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101491682	101491682	+	Silent	SNP	G	G	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:101491682G>T	uc010svm.1	+	21	2537	c.1965G>T	c.(1963-1965)GTG>GTT	p.V655V	ANO4_uc001thw.2_Silent_p.V620V|ANO4_uc001thx.2_Silent_p.V655V|ANO4_uc001thy.2_Silent_p.V175V	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	655	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTATAATGgtgctaaagcaga	0.299		NA								HNSCC(74;0.22)			25	60					3.17e-13	3.78e-13	1	0
CIT	11113	broad.mit.edu	37	12	120172072	120172072	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:120172072G>A	uc001txi.1	-	25	3174	c.3121C>T	c.(3121-3123)CGG>TGG	p.R1041W	CIT_uc001txh.1_Missense_Mutation_p.R575W|CIT_uc001txj.1_Missense_Mutation_p.R1083W	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1041	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCCCACTGCCGCTCTTTTTCT	0.547		NA											34	42					0	0	0	0
UBC	7316	broad.mit.edu	37	12	125397196	125397196	+	Silent	SNP	C	C	T	rs1136634		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:125397196C>T	uc001ugs.3	-	2	1570	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	UBC_uc001ugr.2_Intron|UBC_uc001ugu.1_Silent_p.V374V|UBC_uc001ugt.2_Silent_p.V374V|UBC_uc001ugv.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	374	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGACGGAGCACCAGGTGCA	0.532		NA											5	153					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23444255	23444255	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:23444255T>A	uc001whz.2	-	5	1674	c.1298A>T	c.(1297-1299)AAC>ATC	p.N433I	JUB_uc001why.2_Missense_Mutation_p.N16I	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	433	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CAGGCACTTGTTGCAAACAAT	0.522		NA											57	32					0	0	0	0
MPP5	64398	broad.mit.edu	37	14	67779302	67779302	+	Missense_Mutation	SNP	G	G	A	rs150659640		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:67779302G>A	uc001xjc.2	+	9	1566	c.1100G>A	c.(1099-1101)CGA>CAA	p.R367Q	MPP5_uc001xjd.2_Missense_Mutation_p.R333Q|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	367	SH3.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		GTTCCATGTCGAGAGTTAGGT	0.393		NA											58	18					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088226	94088226	+	Silent	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:94088226A>G	uc001ybv.1	+	28	4265	c.4182A>G	c.(4180-4182)AGA>AGG	p.R1394R	KIAA1409_uc001ybs.1_Silent_p.R1372R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1549						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GACGTTCTAGACAGAACTCTG	0.512		NA											68	33					0	0	0	0
PACS2	23241	broad.mit.edu	37	14	105849787	105849787	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:105849787G>A	uc001yqt.2	+	16	1880	c.1705G>A	c.(1705-1707)GAG>AAG	p.E569K	PACS2_uc001yqs.2_Missense_Mutation_p.E494K|PACS2_uc001yqv.2_Missense_Mutation_p.E573K|PACS2_uc001yqu.2_Missense_Mutation_p.E573K	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	569					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCTTTGTGGAGCAGCTGTC	0.642		NA											47	16					0	0	0	0
SALL1	6299	broad.mit.edu	37	16	51174768	51174768	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:51174768C>T	uc010vgs.1	-	2	1396	c.1365G>A	c.(1363-1365)GCG>GCA	p.A455A	SALL1_uc010vgr.1_Silent_p.A358A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	455	C2H2-type 1.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAAAGACCTTCGCGCAGAACC	0.512		NA											47	59					0	0	0	0
ELMO3	79767	broad.mit.edu	37	16	67235652	67235652	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67235652G>A	uc002esa.2	+	11	1128	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	ELMO3_uc002esb.2_Missense_Mutation_p.R345Q|ELMO3_uc002esc.2_Missense_Mutation_p.R196Q	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	309	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		CAGGAGCAGCGGGAGCAGCTG	0.637		NA											17	37					0	0	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67315718	67315718	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67315718A>G	uc002eso.3	+	6	3518	c.983A>G	c.(982-984)CAG>CGG	p.Q328R	PLEKHG4_uc002esp.3_Missense_Mutation_p.Q135R|PLEKHG4_uc002esq.3_Missense_Mutation_p.Q328R|PLEKHG4_uc010cef.2_Missense_Mutation_p.Q328R|PLEKHG4_uc002ess.3_Missense_Mutation_p.Q328R|PLEKHG4_uc010ceg.2_Missense_Mutation_p.Q247R	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	328					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TACTGCCACCAGGCCTGGCTG	0.617		NA											4	104					0	0	0	0
OR1A2	26189	broad.mit.edu	37	17	3101020	3101020	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:3101020G>A	uc002fvd.1	+	1	208	c.208G>A	c.(208-210)GAC>AAC	p.D70N		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTCCTTGGTTGACATCATCTT	0.483		NA											85	112					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			53	31					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18022714	18022714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:18022714C>T	uc010vxh.1	+	2	938	c.600C>T	c.(598-600)GGC>GGT	p.G200G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	200	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ACGCGTCAGGCGAGCCCCTGG	0.706		NA											12	41					0	0	0	0
VPS25	84313	broad.mit.edu	37	17	40925516	40925516	+	Missense_Mutation	SNP	C	C	T	rs141909224		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:40925516C>T	uc002ibi.2	+	1	63	c.23C>T	c.(22-24)CCG>CTG	p.P8L		NM_032353	NP_115729	Q9BRG1	VPS25_HUMAN	vacuolar protein sorting 25	8					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endosome membrane|nucleoplasm					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		TTCGAGTGGCCGTGGCAGTAT	0.632		NA											26	123					0	0	0	0
MPO	4353	broad.mit.edu	37	17	56352927	56352927	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:56352927C>T	uc002ivu.1	-	8	1518	c.1341G>A	c.(1339-1341)CGG>CGA	p.R447R		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	447			R -> Q (in a colorectal cancer sample; somatic mutation).		anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity	p.R447Q(1)		ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CCACGATCTTCCGGGCTTCCT	0.438		NA											14	44					0	0	0	0
KIAA0195	9772	broad.mit.edu	37	17	73487507	73487507	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:73487507C>A	uc002jnz.3	+	13	1632	c.1357C>A	c.(1357-1359)CTA>ATA	p.L453I	KIAA0195_uc010wsa.1_Missense_Mutation_p.L463I|KIAA0195_uc010wsb.1_Missense_Mutation_p.L105I	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	453					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCGATGGCCTATCCACCCG	0.637		NA											37	69					7.63e-17	9.15e-17	1	0
SAFB	6294	broad.mit.edu	37	19	5641946	5641946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:5641946C>T	uc002mcf.2	+	4	588	c.535C>T	c.(535-537)CAG>TAG	p.Q179*	SAFB_uc010xiq.1_Nonsense_Mutation_p.Q179*|SAFB_uc002mcg.2_Nonsense_Mutation_p.Q179*|SAFB_uc002mce.3_Nonsense_Mutation_p.Q179*|SAFB_uc010xir.1_Nonsense_Mutation_p.Q179*|SAFB_uc010xis.1_Intron|SAFB_uc010xit.1_Intron|SAFB_uc010xiu.1_Intron	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	179					chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GGAGCAGCTTCAGGAACATGC	0.458		NA											27	27					0	0	0	0
AKT2	208	broad.mit.edu	37	19	40741920	40741920	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:40741920T>C	uc002onf.2	-	11	1314	c.1052A>G	c.(1051-1053)TAC>TGC	p.Y351C	AKT2_uc010egs.2_Missense_Mutation_p.Y308C|AKT2_uc010egt.2_Missense_Mutation_p.Y289C|AKT2_uc010xvj.1_Missense_Mutation_p.Y289C|AKT2_uc010egu.1_Missense_Mutation_p.Y289C|AKT2_uc002one.2_Missense_Mutation_p.Y247C	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	351	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			GTCCTGGTTGTAGAAGGGCAG	0.637		NA	A		ovarian|pancreatic 								12	63					0	0	0	0
IRGC	56269	broad.mit.edu	37	19	44223073	44223073	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:44223073G>A	uc002oxh.2	+	2	510	c.363G>A	c.(361-363)CCG>CCA	p.P121P		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	121						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CAGGCTGCCCGGCTGACAAGT	0.657		NA											7	32					0	0	0	0
OPA3	80207	broad.mit.edu	37	19	46056884	46056884	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:46056884G>A	uc002pck.3	-	2	528	c.428C>T	c.(427-429)GCG>GTG	p.A143V	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.A90V	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	143	Potential.				response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CTGTGGCGGCGCCGCCTGCAC	0.726		NA											7	41					0	0	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914354	51914354	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:51914354C>T	uc002pwo.2	-	11	2709	c.2093G>A	c.(2092-2094)TGA>TAA	p.*698*	SIGLEC10_uc002pwp.2_Silent_p.*640*|SIGLEC10_uc002pwq.2_Silent_p.*545*|SIGLEC10_uc002pwr.2_Silent_p.*603*|SIGLEC10_uc010ycy.1_Silent_p.*513*|SIGLEC10_uc010ycz.1_Silent_p.*555*|SIGLEC10_uc010eow.2_Silent_p.*415*	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	698					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AAGAGACCCTCATTGGAACTT	0.502		NA											61	38					0	0	0	0
RSAD2	91543	broad.mit.edu	37	2	7027109	7027109	+	Silent	SNP	C	C	T	rs111620392	byFrequency	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:7027109C>T	uc002qyp.1	+	3	688	c.552C>T	c.(550-552)GAC>GAT	p.D184D		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	184					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACAGCTTTGACGAGGAAGTCA	0.458		NA											15	37					0	0	0	0
FOSL2	2355	broad.mit.edu	37	2	28627022	28627022	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:28627022A>G	uc002rma.2	+	2	960	c.151A>G	c.(151-153)ATC>GTC	p.I51V	FOSL2_uc010ymi.1_Missense_Mutation_p.I12V	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	51					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CATCCCCACCATCAACGCCAT	0.517		NA											27	98					0	0	0	0
LIMS1	3987	broad.mit.edu	37	2	109292348	109292348	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:109292348C>T	uc002teg.2	+	6	628	c.509C>T	c.(508-510)GCC>GTC	p.A170V	LIMS1_uc002tef.2_Missense_Mutation_p.A182V|LIMS1_uc002teh.2_Missense_Mutation_p.A170V|LIMS1_uc002tei.2_Missense_Mutation_p.A170V|LIMS1_uc002tej.2_Missense_Mutation_p.A207V|LIMS1_uc002tek.3_Missense_Mutation_p.A232V	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	170	LIM zinc-binding 3.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						GAGCTGACTGCCGATGCACGG	0.527		NA											4	93					0	0	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125282021	125282021	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:125282021A>G	uc002tno.2	+	9	1830	c.1466A>G	c.(1465-1467)TAT>TGT	p.Y489C	CNTNAP5_uc010flu.2_Missense_Mutation_p.Y490C	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	489	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATAGCTACTATTTTGGAGGT	0.448		NA											16	19					0	0	0	0
IWS1	55677	broad.mit.edu	37	2	128255753	128255753	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:128255753C>T	uc002ton.2	-	6	1831	c.1528G>A	c.(1528-1530)GAT>AAT	p.D510N	IWS1_uc010yzl.1_Intron	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	510					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GAATCTGAATCTTCTGCTTCT	0.303		NA											34	44					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136575285	136575285	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:136575285C>T	uc002tuu.1	-	6	1344	c.1333G>A	c.(1333-1335)GGC>AGC	p.G445S		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	445	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCCCGGAGGCCGCAAAGCAGG	0.642		NA											33	81					0	0	0	0
KIF5C	3800	broad.mit.edu	37	2	149868101	149868101	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:149868101G>A	uc010zbu.1	+	25	3153	c.2785G>A	c.(2785-2787)GGA>AGA	p.G929R	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Missense_Mutation_p.G211R	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	929	Globular.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CATCCGCCCCGGACACTACCC	0.498		NA											4	82					0	0	0	0
HECW2	57520	broad.mit.edu	37	2	197182030	197182030	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:197182030C>T	uc002utm.1	-	10	2585	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	HECW2_uc002utl.1_Missense_Mutation_p.R445Q	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	801	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCTCTGGTACCGGCTAACATC	0.517		NA											6	14					0	0	0	0
FARSB	10056	broad.mit.edu	37	2	223520788	223520788	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:223520788G>A	uc002vne.1	-	1	40	c.5C>T	c.(4-6)CCG>CTG	p.P2L	FARSB_uc010zlq.1_Missense_Mutation_p.P2L|FARSB_uc002vnf.1_5'UTR|FARSB_uc002vng.1_RNA	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	2					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GCTGACAGTCGGCATGGTGTG	0.627		NA											10	6					0	0	0	0
NEU2	4759	broad.mit.edu	37	2	233899356	233899356	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:233899356C>T	uc010zmn.1	+	2	732	c.732C>T	c.(730-732)GTC>GTT	p.V244V		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	244							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GAGCCAGGGTCCAGGCCCAGA	0.652		NA											18	52					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9360788	9360788	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:9360788G>C	uc002wnf.2	+	12	968	c.832G>C	c.(832-834)GAT>CAT	p.D278H	PLCB4_uc010gbw.1_Missense_Mutation_p.D278H|PLCB4_uc010gbx.2_Missense_Mutation_p.D278H|PLCB4_uc002wne.2_Missense_Mutation_p.D278H|PLCB4_uc002wnh.2_Missense_Mutation_p.D125H	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	278					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GTATGAACCTGATGAAGATTT	0.294		NA											8	24					0	0	0	0
KIF16B	55614	broad.mit.edu	37	20	16360188	16360188	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:16360188T>C	uc002wpg.1	-	19	2617	c.2459A>G	c.(2458-2460)AAG>AGG	p.K820R	KIF16B_uc002wpe.1_Missense_Mutation_p.K202R|KIF16B_uc002wpf.1_Missense_Mutation_p.K202R|KIF16B_uc010gch.1_Missense_Mutation_p.K820R|KIF16B_uc010gci.1_Missense_Mutation_p.K820R|KIF16B_uc010gcj.1_Missense_Mutation_p.K831R	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	820	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CAGTTGAGCCTTTTCTAACTC	0.517		NA											3	87					0	0	0	0
TAF4	6874	broad.mit.edu	37	20	60584189	60584189	+	Silent	SNP	A	A	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:60584189A>T	uc002ybs.2	-	5	1803	c.1803T>A	c.(1801-1803)TCT>TCA	p.S601S		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	601	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTATTAACGTAGATAGGAAAT	0.353		NA											19	49					0	0	0	0
SUSD5	26032	broad.mit.edu	37	3	33195134	33195134	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:33195134G>A	uc003cfo.1	-	5	1408	c.990C>T	c.(988-990)GTC>GTT	p.V330V		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	330	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						GTTCACCTGGGACCAATTTTA	0.517		NA											17	12					0	0	0	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438		NA											87	46					0	0	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50683618	50683618	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:50683618C>T	uc003day.1	+	10	1348	c.752C>T	c.(751-753)TCC>TTC	p.S251F	MAPKAPK3_uc003daz.1_Missense_Mutation_p.S251F|MAPKAPK3_uc003dba.1_Missense_Mutation_p.S251F|MAPKAPK3_uc010hlr.1_Missense_Mutation_p.S251F	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	251	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CAGGCCATCTCCCCGGGGATG	0.597		NA											94	58					0	0	0	0
CCDC66	285331	broad.mit.edu	37	3	56651600	56651600	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:56651600G>A	uc003dhz.2	+	14	2391	c.2304G>A	c.(2302-2304)ACG>ACA	p.T768T	CCDC66_uc003dhy.2_Silent_p.T404T|CCDC66_uc003dhu.2_Silent_p.T734T|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_Silent_p.T136T	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	768										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		ATCAAGAAACGGAGTCAAAGT	0.378		NA											10	15					0	0	0	0
CNTN3	5067	broad.mit.edu	37	3	74315641	74315641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:74315641G>A	uc003dpm.1	-	21	3057	c.2977C>T	c.(2977-2979)CGA>TGA	p.R993*		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	993					cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTGGTTATTCGTGGAATCCTG	0.428		NA											89	67					0	0	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113659107	113659107	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:113659107C>G	uc003eaq.3	+	17	1899	c.1823C>G	c.(1822-1824)TCA>TGA	p.S608*	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc003ear.2_Nonsense_Mutation_p.S441*|GRAMD1C_uc003eas.2_Nonsense_Mutation_p.S403*|GRAMD1C_uc003eat.2_Nonsense_Mutation_p.S267*	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	608						integral to membrane				ovary(2)|skin(1)	3						GATATGGTGTCAAGAGCAGAA	0.408		NA											53	169					0	0	0	0
SI	6476	broad.mit.edu	37	3	164777066	164777066	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:164777066C>G	uc003fei.2	-	11	1230	c.1168G>C	c.(1168-1170)GAC>CAC	p.D390H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	390	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCATGTAGTCAATATCAGTG	0.358		NA								HNSCC(35;0.089)			7	52					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			49	24					0	0	0	0
TP63	8626	broad.mit.edu	37	3	189349311	189349311	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:189349311T>C	uc003fry.2	+	1	96	c.7T>C	c.(7-9)TTT>CTT	p.F3L	TP63_uc003frx.2_Missense_Mutation_p.F3L|TP63_uc003frz.2_Missense_Mutation_p.F3L|TP63_uc010hzc.1_Missense_Mutation_p.F3L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	3	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GGAAATGAATTTTGAAACTTC	0.378		NA							Hay-Wells_syndrome	HNSCC(45;0.13)			73	70					0	0	0	0
C3orf59	151963	broad.mit.edu	37	3	192516654	192516654	+	Silent	SNP	G	G	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:192516654G>T	uc011bsp.1	-	2	1318	c.997C>A	c.(997-999)CGG>AGG	p.R333R		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	333											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ATCATGCTCCGCAGGTGATAG	0.552		NA											28	82					9.04e-07	1.06e-06	1	0
KIAA1211	57482	broad.mit.edu	37	4	57182124	57182124	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:57182124C>T	uc003hbk.2	+	8	2847	c.2456C>T	c.(2455-2457)TCG>TTG	p.S819L	KIAA1211_uc010iha.2_Missense_Mutation_p.S812L|KIAA1211_uc011bzz.1_Missense_Mutation_p.S729L|KIAA1211_uc003hbm.1_Missense_Mutation_p.S705L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	819										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					TTCACGACCTCGTCGGACAGC	0.537		NA											25	54					0	0	0	0
AFM	173	broad.mit.edu	37	4	74351714	74351714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:74351714C>T	uc003hhb.2	+	4	437	c.406C>T	c.(406-408)CTG>TTG	p.L136L		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	136	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTGGGATTTCTGCCTCCTTT	0.398		NA											16	39					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111397714	111397714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:111397714C>T	uc003iab.3	+	1	486	c.144C>T	c.(142-144)GAC>GAT	p.D48D		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	48	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CCAGCGGGGACGGCGGGCCGG	0.637		NA											15	110					0	0	0	0
MTNR1A	4543	broad.mit.edu	37	4	187454891	187454891	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:187454891C>T	uc003izd.1	-	2	1023	c.1005G>A	c.(1003-1005)CCG>CCA	p.P335P		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	335	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCAGTGGAGACGGTTTCCATT	0.493		NA											24	68					0	0	0	0
TRIP13	9319	broad.mit.edu	37	5	908535	908535	+	Silent	SNP	C	C	T	rs146441673		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:908535C>T	uc003jbr.2	+	9	935	c.825C>T	c.(823-825)CGC>CGT	p.R275R	TRIP13_uc010ite.1_Silent_p.R275R	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	275					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			ATGCCATCCGCGTGGTCAATG	0.522		NA											22	65					0	0	0	0
MTRR	4552	broad.mit.edu	37	5	7870928	7870928	+	Silent	SNP	A	A	G	rs114427781	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:7870928A>G	uc003jed.2	+	2	132	c.102A>G	c.(100-102)CTA>CTG	p.L34L	FASTKD3_uc011cmp.1_5'Flank|FASTKD3_uc003jeb.2_5'Flank|FASTKD3_uc003jec.2_5'Flank|MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Silent_p.L7L|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	34	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTCTGTTACTATATGCTACAC	0.403		NA											24	30					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71494372	71494372	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:71494372G>A	uc003kbw.3	+	5	5431	c.5190G>A	c.(5188-5190)CCG>CCA	p.P1730P	MAP1B_uc010iyw.1_Silent_p.P1747P|MAP1B_uc010iyx.1_Silent_p.P1604P|MAP1B_uc010iyy.1_Silent_p.P1604P	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1730						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGGCCTCCCCGTCCACCTCTT	0.483		NA											84	121					0	0	0	0
PDE8B	8622	broad.mit.edu	37	5	76704787	76704787	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:76704787C>G	uc003kfa.2	+	14	1480	c.1435C>G	c.(1435-1437)CTA>GTA	p.L479V	PDE8B_uc003kfb.2_Missense_Mutation_p.L459V|PDE8B_uc003kfc.2_Intron|PDE8B_uc003kfd.2_Missense_Mutation_p.L432V|PDE8B_uc003kfe.2_Missense_Mutation_p.L382V	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	479					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GGACAGAGTTCTAGAGATTTT	0.463		NA											12	38					0	0	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503125	140503125	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140503125C>T	uc003lip.1	+	1	1545	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	515	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGCCCTCAGGTCGCTGG	0.697		NA											52	121					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718650	140718650	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140718650G>C	uc003ljk.1	+	1	297	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E38Q	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	38	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCGGGAAGAGATCGACAG	0.597		NA									OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	57					0	0	0	0
TCERG1	10915	broad.mit.edu	37	5	145851118	145851118	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:145851118C>T	uc003lob.2	+	9	1620	c.1580C>T	c.(1579-1581)GCT>GTT	p.A527V	TCERG1_uc003loc.2_Missense_Mutation_p.A506V|TCERG1_uc011dbt.1_Missense_Mutation_p.A506V	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	527					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGCTACTGCTCCTATTCCT	0.303		NA											16	38					0	0	0	0
PDGFRB	5159	broad.mit.edu	37	5	149514571	149514571	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:149514571C>T	uc003lro.2	-	4	842	c.373G>A	c.(373-375)GTG>ATG	p.V125M	PDGFRB_uc010jhd.2_Translation_Start_Site|PDGFRB_uc011dcg.1_Missense_Mutation_p.V125M	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	125	Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGGAAGCCCACGGTGGGATCT	0.343		NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								41	33					0	0	0	0
HIST1H2AD	3013	broad.mit.edu	37	6	26199448	26199448	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:26199448G>A	uc003ngw.2	-	1	24	c.24C>T	c.(22-24)GGC>GGT	p.G8G	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	8					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				GGGCCTTTCCGCCTTGCTTGC	0.507		NA											12	29					0	0	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833460	27833460	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:27833460C>A	uc003njw.2	+	1	354	c.328C>A	c.(328-330)CCC>ACC	p.P110T		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	110					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						TGGTGTCCTGCCCAACATCCA	0.552		NA											64	98					1.53e-18	1.84e-18	1	0
PHF3	23469	broad.mit.edu	37	6	64422967	64422967	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:64422967T>C	uc003pep.1	+	15	5509	c.5483T>C	c.(5482-5484)ATG>ACG	p.M1828T	PHF3_uc003pen.2_Missense_Mutation_p.M1740T|PHF3_uc011dxs.1_Missense_Mutation_p.M1097T	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1828	Pro-rich.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCACAAAGCATGTTTGGATTT	0.512		NA											91	128					0	0	0	0
SOBP	55084	broad.mit.edu	37	6	107956339	107956339	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:107956339C>T	uc003prx.2	+	6	2795	c.2291C>T	c.(2290-2292)GCG>GTG	p.A764V		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	764							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GAGGAACCGGCGGTGAGCGAG	0.607		NA											7	27					0	0	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350301	134350301	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:134350301G>C	uc003qem.1	-	2	833	c.662C>G	c.(661-663)CCT>CGT	p.P221R		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	221	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		CAGAAACCGAGGGCTTGGAGG	0.448		NA											30	60					0	0	0	0
C6orf70	55780	broad.mit.edu	37	6	170156467	170156467	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:170156467C>T	uc003qxg.1	+	4	382	c.349C>T	c.(349-351)CTA>TTA	p.L117L	C6orf70_uc011ehb.1_5'UTR|C6orf70_uc003qxh.1_Silent_p.L117L|C6orf70_uc010kky.1_5'UTR	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	117						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTTGGAAAGTCTACAATCTCC	0.348		NA											9	48					0	0	0	0
INTS1	26173	broad.mit.edu	37	7	1517526	1517526	+	Silent	SNP	C	C	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:1517526C>A	uc003skn.2	-	34	4778	c.4677G>T	c.(4675-4677)CTG>CTT	p.L1559L	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1559					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ATGCAGTCAGCAGCTCCTCCA	0.647		NA											6	77					2.01e-06	2.34e-06	1	0
CPVL	54504	broad.mit.edu	37	7	29105714	29105714	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:29105714G>A	uc003szv.2	-	10	1007	c.888C>T	c.(886-888)GGC>GGT	p.G296G	CPVL_uc003szw.2_Silent_p.G296G|CPVL_uc003szx.2_Silent_p.G296G	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	296					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TTGTTAAGTCGCCATCTAGTA	0.299		NA											11	42					0	0	0	0
TSC22D4	81628	broad.mit.edu	37	7	100075277	100075277	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:100075277C>T	uc003uva.2	-	2	1140	c.385G>A	c.(385-387)GAG>AAG	p.E129K	TSC22D4_uc003uvb.2_Intron|TSC22D4_uc011kjv.1_Intron|TSC22D4_uc010lgx.2_Missense_Mutation_p.E129K|TSC22D4_uc003uvc.3_Missense_Mutation_p.E129K	NM_030935	NP_112197	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	129					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGCCAGCTCCAACCTGGAA	0.692		NA											7	6					0	0	0	0
SSPO	23145	broad.mit.edu	37	7	149486777	149486777	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:149486777C>T	uc010lpk.2	+	31	4551	c.4551C>T	c.(4549-4551)TGC>TGT	p.C1517C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1517	LDL-receptor class A 4.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCTGGGACTGCCCAGATGGAG	0.667		NA											9	16					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151891214	151891214	+	Splice_Site	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:151891214C>G	uc003wla.2	-	31	4760	c.4541_splice	c.e31-1	p.E1514_splice	MLL3_uc003wkz.2_Splice_Site_p.E575_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCGCCAAGCTCTAGGAGATAA	0.418		NA	N		medulloblastoma								10	27					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618583	77618583	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:77618583G>A	uc003yav.2	+	2	2647	c.2260G>A	c.(2260-2262)GGA>AGA	p.G754R	ZFHX4_uc003yat.1_Missense_Mutation_p.G754R|ZFHX4_uc003yau.1_Missense_Mutation_p.G754R|ZFHX4_uc003yaw.1_Missense_Mutation_p.G754R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	754						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTGGCTGCGGAACACCCTC	0.527		NA								HNSCC(33;0.089)			25	19					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87638274	87638274	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:87638274C>T	uc003ydx.2	-	13	1561	c.1515G>A	c.(1513-1515)ACG>ACA	p.T505T	CNGB3_uc010maj.2_Silent_p.T367T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	505	Helical; Name=H6; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CTAACTGGACCGTAGTTGGTA	0.383		NA											20	42					0	0	0	0
ZNF251	90987	broad.mit.edu	37	8	145948537	145948537	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:145948537C>T	uc003zdv.3	-	5	764	c.508G>A	c.(508-510)GTG>ATG	p.V170M		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCCCTGCCCACGGTAGCTTCT	0.438		NA											106	133					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			17	10					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77386695	77386695	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:77386695C>T	uc004ajl.1	-	25	3698	c.3460G>A	c.(3460-3462)GTG>ATG	p.V1154M	TRPM6_uc004ajk.1_Missense_Mutation_p.V1149M|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.V110M	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1154	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TATTTTTCCACGCACTGCTCC	0.353		NA											8	45					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32591889	32591889	+	Silent	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:32591889G>C	uc004dda.1	-	14	1921	c.1677C>G	c.(1675-1677)CTC>CTG	p.L559L	DMD_uc004dcz.2_Silent_p.L436L|DMD_uc004dcy.1_Silent_p.L555L|DMD_uc004ddb.1_Silent_p.L551L|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.L551L|DMD_uc010ngp.1_Nonsense_Mutation_p.S79*|DMD_uc010ngq.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	559	Spectrin 3.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTGCCATTTGAGAAGGATGT	0.423		NA											7	6					0	0	0	0
MID2	11043	broad.mit.edu	37	X	107159287	107159287	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:107159287G>C	uc004enl.2	+	6	1702	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	MID2_uc004enk.2_Missense_Mutation_p.D377H	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	377	COS.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CAATTTTAATGATGCCTTTGA	0.353		NA											33	14					0	0	0	0
USP26	83844	broad.mit.edu	37	X	132161099	132161099	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:132161099G>C	uc010nrm.1	-	6	1620	c.1150C>G	c.(1150-1152)CAT>GAT	p.H384D	USP26_uc011mvf.1_Missense_Mutation_p.H384D	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	384					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AAAAACTCATGAGCATCGTTC	0.358		NA											24	14					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196311261	196311262	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:196311261_196311262insA	uc001gtd.1	-	15	1560_1561	c.1500_1501insT	c.(1498-1503)TTTGCTfs	p.F500fs	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Frame_Shift_Ins_p.F500fs|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Frame_Shift_Ins_p.F500fs|KCNT2_uc001gth.1_Frame_Shift_Ins_p.F21fs	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	500_501	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCATATTCAGCAAAAAATGTAC	0.391		NA											16	34	---	---	---	---	NA	NA	NA	NA
GABRA5	2558	broad.mit.edu	37	15	27188544	27188544	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr15:27188544delA	uc001zbd.1	+	11	1399	c.1060delA	c.(1060-1062)AAAfs	p.K354fs	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	354	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGGGATGGCAAAAAAGCCTT	0.498		NA											2	4	---	---	---	---	NA	NA	NA	NA
STK25	10494	broad.mit.edu	37	2	242438109	242438110	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:242438109_242438110insA	uc002wbm.2	-	7	1132_1133	c.861_862insT	c.(859-864)TATAAGfs	p.Y287fs	STK25_uc002wbk.2_Frame_Shift_Ins_p.Y106fs|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Frame_Shift_Ins_p.Y287fs|STK25_uc002wbo.2_Frame_Shift_Ins_p.Y210fs|STK25_uc010zos.1_Frame_Shift_Ins_p.Y193fs|STK25_uc010zot.1_Frame_Shift_Ins_p.Y213fs|STK25_uc002wbp.2_Frame_Shift_Ins_p.Y287fs|STK25_uc010fzo.2_Frame_Shift_Ins_p.Y210fs|STK25_uc010zou.1_Frame_Shift_Ins_p.Y193fs|STK25_uc010zov.1_Frame_Shift_Ins_p.Y193fs	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	287_288					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTCCAGCGCTTATAGCGGTCGA	0.584		NA											27	104	---	---	---	---	NA	NA	NA	NA
BCL2L1	598	broad.mit.edu	37	20	30309591	30309591	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:30309591delA	uc002wwl.2	-	2	797	c.431delT	c.(430-432)TTCfs	p.F144fs	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Intron|BCL2L1_uc002wwn.2_Frame_Shift_Del_p.F144fs|BCL2L1_uc002wwo.1_Frame_Shift_Del_p.F144fs	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	144	BH1.				induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542		NA											7	365	---	---	---	---	NA	NA	NA	NA
