Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
IL22RA1	58985	broad.mit.edu	37	1	24465129	24465129	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:24465129G>A	uc001biq.1	-	2	158	c.119C>T	c.(118-120)ACG>ATG	p.T40M	IL22RA1_uc010oeg.1_5'Flank|IL22RA1_uc009vrb.1_Translation_Start_Site|IL22RA1_uc010oeh.1_Missense_Mutation_p.T40M	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	40	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCTGTCCCACGTCAGGATGTT	0.582		NA											14	84					0	0	0	0
EIF2C3	192669	broad.mit.edu	37	1	36474311	36474311	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:36474311C>G	uc001bzp.2	+	7	1070	c.814C>G	c.(814-816)CAT>GAT	p.H272D	EIF2C3_uc001bzq.2_Missense_Mutation_p.H38D	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	272	PAZ.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGAAGTGACTCATTGTGGAAC	0.393		NA											39	100					0	0	0	0
LRRC41	10489	broad.mit.edu	37	1	46745880	46745880	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:46745880C>T	uc001cpn.2	-	7	2048	c.2004G>A	c.(2002-2004)CAG>CAA	p.Q668Q	LRRC41_uc010omb.1_Silent_p.Q668Q	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	668										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GAGTCAGATTCTGTAGCAAAA	0.303		NA											25	67					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91727872	91727872	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:91727872G>T	uc001doa.3	-	38	4264	c.4164C>A	c.(4162-4164)AAC>AAA	p.N1388K	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.N1067K|HFM1_uc001dob.3_Missense_Mutation_p.N576K	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1388							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AAGAATTTGGGTTTTTTTCAG	0.284		NA											50	83					4e-15	4.58e-15	1	0
CSDE1	7812	broad.mit.edu	37	1	115261328	115261328	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:115261328C>T	uc001efk.2	-	19	2721	c.2255G>A	c.(2254-2256)CGG>CAG	p.R752Q	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Missense_Mutation_p.R798Q|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.R721Q|CSDE1_uc001efm.2_Missense_Mutation_p.R767Q|CSDE1_uc009wgv.2_Missense_Mutation_p.R752Q|CSDE1_uc001efn.2_Missense_Mutation_p.R721Q	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	752					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTGACCAACCGATCAGGTCG	0.498		NA											3	71					0	0	0	0
TMEM79	84283	broad.mit.edu	37	1	156255560	156255560	+	Silent	SNP	G	G	A	rs140033065	byFrequency	TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:156255560G>A	uc010phi.1	+	2	739	c.543G>A	c.(541-543)CCG>CCA	p.P181P	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Silent_p.P22P|TMEM79_uc009wrw.2_Silent_p.P181P	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	181						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TGGTGAGGCCGCCTGGCTGTT	0.682		NA											35	52					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243727052	243727052	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:243727052G>A	uc001iab.1	-	9	999	c.918C>T	c.(916-918)TTC>TTT	p.F306F	AKT3_uc001hzz.1_Silent_p.F306F	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	306	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAGTGCCACAGAATGTCTTCA	0.398		NA											38	131					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63852287	63852287	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:63852287T>C	uc001jlt.1	+	10	3091	c.3065T>C	c.(3064-3066)GTG>GCG	p.V1022A		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1022					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					TTGGACCTTGTGATTGCAGGG	0.587		NA											72	113					0	0	0	0
BTAF1	9044	broad.mit.edu	37	10	93719841	93719841	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:93719841T>G	uc001khr.2	+	11	1291	c.1193T>G	c.(1192-1194)CTT>CGT	p.L398R	BTAF1_uc001khs.1_Missense_Mutation_p.L68R	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	398	HEAT 1.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				CTAAAATTACTTACACAAGAA	0.393		NA											61	111					0	0	0	0
LDB1	8861	broad.mit.edu	37	10	103867955	103867955	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:103867955G>A	uc009xwz.2	-	11	1474	c.1131C>T	c.(1129-1131)AGC>AGT	p.S377S	LDB1_uc001kuk.3_Silent_p.S341S	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	377					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		AGTTGTTAAAGCTGTCCTCGT	0.622		NA											71	117					0	0	0	0
SLC6A5	9152	broad.mit.edu	37	11	20622730	20622730	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr11:20622730C>T	uc001mqd.2	+	2	332	c.59C>T	c.(58-60)GCG>GTG	p.A20V	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	20	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CCGGAGGCGGCGGCGGCGCAG	0.652		NA											8	7					0	0	0	0
CD163	9332	broad.mit.edu	37	12	7639365	7639365	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:7639365C>A	uc001qsz.3	-	10	2316	c.2188G>T	c.(2188-2190)GGG>TGG	p.G730W	CD163_uc001qta.3_Missense_Mutation_p.G730W|CD163_uc009zfw.2_Missense_Mutation_p.G763W	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	730	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCTACTCTCCCAGCACAGCGA	0.483		NA											9	205					0.00448238	0.00475459	1	0
MLL2	8085	broad.mit.edu	37	12	49418485	49418485	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:49418485C>T	uc001rta.3	-	50	15928	c.15928G>A	c.(15928-15930)GGG>AGG	p.G5310R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5310	FYR C-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCTCCACCCCGGGCAGCTGT	0.582		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	20					0	0	0	0
DIP2B	57609	broad.mit.edu	37	12	51072578	51072578	+	Missense_Mutation	SNP	C	C	T	rs145274091		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:51072578C>T	uc001rwv.2	+	8	1189	c.1033C>T	c.(1033-1035)CGC>TGC	p.R345C	DIP2B_uc001rwu.2_Missense_Mutation_p.R345C|DIP2B_uc009zls.1_Missense_Mutation_p.R227C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	345						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGCCCTGCAGCGCTGGGGTAC	0.532		NA											36	64					0	0	0	0
ACVRL1	94	broad.mit.edu	37	12	52307464	52307464	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:52307464G>A	uc001rzj.2	+	4	718	c.435G>A	c.(433-435)CGG>CGA	p.R145R	ACVRL1_uc001rzk.2_Silent_p.R145R|ACVRL1_uc010snm.1_Intron	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	145	Cytoplasmic (Potential).				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	ATGTCCGACGGAGGCAGGAGA	0.662		NA							Hereditary_Hemorrhagic_Telangiectasia				20	28					0	0	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876860	53876860	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:53876860C>A	uc001sdm.1	-	12	1726	c.1628G>T	c.(1627-1629)GGC>GTC	p.G543V	MAP3K12_uc001sdn.1_Missense_Mutation_p.G576V	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	543					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						ACGGGTCTTGCCACGGCGACT	0.647		NA											36	40					1.42e-22	1.65e-22	1	0
PARP4	143	broad.mit.edu	37	13	25068806	25068806	+	Missense_Mutation	SNP	C	C	G	rs145170390		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:25068806C>G	uc001upl.2	-	7	752	c.646G>C	c.(646-648)GAA>CAA	p.E216Q	PARP4_uc010tdc.1_Missense_Mutation_p.E216Q	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	216					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATGTAATTTTCAAAGTATTCA	0.338		NA											43	17					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328310	88328310	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:88328310C>G	uc001vln.2	+	2	886	c.667C>G	c.(667-669)CAC>GAC	p.H223D	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	223	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCTCTTGCAGCACATGGATAA	0.498		NA											4	137					0	0	0	0
ATP11A	23250	broad.mit.edu	37	13	113530144	113530144	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:113530144C>T	uc001vsi.3	+	28	3304	c.3216C>T	c.(3214-3216)AGC>AGT	p.S1072S	ATP11A_uc001vsj.3_Silent_p.S1072S|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1072	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCTGTCCAGCGGGCCCGCCT	0.612		NA											69	23					0	0	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724510	38724510	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:38724510C>A	uc001wum.1	-	1	1065	c.718G>T	c.(718-720)GGC>TGC	p.G240C		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	240	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AACACATCGCCCGAGAGTTTG	0.622		NA											21	338					6.45e-10	7.31e-10	1	0
FSCB	84075	broad.mit.edu	37	14	44976120	44976120	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:44976120C>A	uc001wvn.2	-	1	380	c.71G>T	c.(70-72)AGC>ATC	p.S24I		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	24						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTTTGGGGCTAGATGATTT	0.423		NA											145	202					2.99e-77	3.53e-77	1	0
PELI2	57161	broad.mit.edu	37	14	56755238	56755238	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:56755238C>T	uc001xch.2	+	4	679	c.393C>T	c.(391-393)ATC>ATT	p.I131I		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	131					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						AAGCCCAGATCACACAGAGCA	0.502		NA											16	26					0	0	0	0
LGMN	5641	broad.mit.edu	37	14	93182496	93182496	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:93182496C>T	uc001yav.2	-	6	715	c.389G>A	c.(388-390)GGC>GAC	p.G130D	LGMN_uc001yat.2_Missense_Mutation_p.G130D|LGMN_uc001yau.2_Missense_Mutation_p.G130D|LGMN_uc001yaw.2_Missense_Mutation_p.G130D|LGMN_uc010aul.2_Intron|LGMN_uc001yax.2_Missense_Mutation_p.G130D|LGMN_uc001yay.2_Missense_Mutation_p.G130D	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	130					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		CAGGACTTTGCCGGATCCTAT	0.468		NA											4	198					0	0	0	0
TRAF3	7187	broad.mit.edu	37	14	103371927	103371927	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:103371927C>T	uc001ymc.1	+	12	1866	c.1513C>T	c.(1513-1515)CGA>TGA	p.R505*	TRAF3_uc001yme.1_Nonsense_Mutation_p.R480*|TRAF3_uc001ymd.1_Nonsense_Mutation_p.R505*|TRAF3_uc010txy.1_Nonsense_Mutation_p.R422*	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	505	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GGGGTCCTCTCGACGTCATTT	0.517		NA											161	36					0	0	0	0
MLST8	64223	broad.mit.edu	37	16	2258607	2258607	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr16:2258607C>T	uc002coz.2	+	8	974	c.855C>T	c.(853-855)ATC>ATT	p.I285I	MLST8_uc002coy.2_Silent_p.I285I|MLST8_uc002cpa.2_Silent_p.I101I|MLST8_uc002cpb.2_Silent_p.I284I|MLST8_uc010uvx.1_Silent_p.I219I|MLST8_uc002cpc.2_Silent_p.I285I|MLST8_uc002cpd.2_Silent_p.I219I|MLST8_uc002cpe.2_Silent_p.I285I|MLST8_uc002cpg.2_Silent_p.I304I|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Silent_p.I285I	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	285	WD 7.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						CCCAGTACATCGTCACTGGTG	0.711		NA											46	70					0	0	0	0
RFWD3	55159	broad.mit.edu	37	16	74695298	74695298	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr16:74695298G>A	uc002fda.2	-	2	148	c.50C>T	c.(49-51)GCC>GTC	p.A17V	RFWD3_uc010cgq.2_Missense_Mutation_p.A17V	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	17					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTGTTGTTCGGCATGATTTAA	0.478		NA											4	224					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7751611	7751611	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:7751611C>T	uc002giw.1	+	11	2381	c.2005C>T	c.(2005-2007)CGA>TGA	p.R669*	KDM6B_uc002gix.2_5'UTR	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	669	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCGAGGCCCTCGACTCTTTGA	0.647		NA											61	79					0	0	0	0
HNF1B	6928	broad.mit.edu	37	17	36091723	36091723	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:36091723C>T	uc002hok.3	-	4	1129	c.908G>A	c.(907-909)CGC>CAC	p.R303H	HNF1B_uc010wdi.1_Missense_Mutation_p.R277H|HNF1B_uc010cve.1_Missense_Mutation_p.R111H	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	303	Homeobox; HNF1-type.				endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CTCCTTCCTGCGGTTTGCAAA	0.607		NA							Hereditary_Prostate_Cancer				59	100					0	0	0	0
GRN	2896	broad.mit.edu	37	17	42427094	42427094	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:42427094C>T	uc002igp.1	+	4	543	c.324C>T	c.(322-324)GAC>GAT	p.D108D	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	108					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCAGTGCAGACGGGCGATCCT	0.637		NA											18	36					0	0	0	0
TIMP2	7077	broad.mit.edu	37	17	76851860	76851860	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:76851860G>A	uc002jwf.2	-	5	854	c.552C>T	c.(550-552)AAC>AAT	p.N184N	TIMP2_uc002jwe.2_Silent_p.N107N|TIMP2_uc010wty.1_Silent_p.N107N	NM_003255	NP_003246	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2 precursor	184							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			CCTGGTGCCCGTTGATGTTCT	0.632		NA											43	65					0	0	0	0
FLJ35220	284131	broad.mit.edu	37	17	78389501	78389501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:78389501G>A	uc002jym.1	+	2	136	c.108G>A	c.(106-108)TGG>TGA	p.W36*	uc002jyi.1_5'Flank|FLJ35220_uc002jyj.1_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyk.2_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyl.1_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyn.2_5'UTR	NM_173627	NP_775898	Q8N8Q3	ENDOV_HUMAN	hypothetical protein LOC284131 isoform 1	36					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			CCGAGGCGTGGCAGCGAGACC	0.642		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					3	20					0	0	0	0
RALBP1	10928	broad.mit.edu	37	18	9535827	9535827	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr18:9535827G>A	uc002kob.2	+	10	2083	c.1860G>A	c.(1858-1860)CCG>CCA	p.P620P	RALBP1_uc002koc.2_Silent_p.P620P	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	620					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						CCGTCCAGCCGCCCAGAGACG	0.667		NA											6	11					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18547018	18547018	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr18:18547018G>A	uc002kte.2	-	27	4153	c.3212C>T	c.(3211-3213)GCA>GTA	p.A1071V		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1071	Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ATTCCTATGTGCACATTCTTC	0.333		NA											63	96					0	0	0	0
DNM2	1785	broad.mit.edu	37	19	10887831	10887831	+	Silent	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:10887831G>C	uc002mps.1	+	5	791	c.627G>C	c.(625-627)CTG>CTC	p.L209L	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.L209L|DNM2_uc002mpv.1_Silent_p.L209L|DNM2_uc002mpu.1_Silent_p.L209L|DNM2_uc010dxl.1_Silent_p.L209L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	209					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AGCTTGACCTGATGGACGAGG	0.532		NA											27	60					0	0	0	0
ZNF433	163059	broad.mit.edu	37	19	12126251	12126251	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:12126251C>T	uc002msy.1	-	4	1602	c.1431G>A	c.(1429-1431)CCG>CCA	p.P477P	uc002msx.1_Intron|ZNF433_uc002msz.1_Silent_p.P442P	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACATTCATACGGCTTCTCTT	0.388		NA											19	41					0	0	0	0
ZNF90	7643	broad.mit.edu	37	19	20228642	20228642	+	Silent	SNP	T	T	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:20228642T>C	uc002nor.2	+	4	418	c.279T>C	c.(277-279)GAT>GAC	p.D93D	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	93						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCCTAAAAGATTCCTTCCAAA	0.343		NA											5	24					0	0	0	0
MAG	4099	broad.mit.edu	37	19	35800939	35800939	+	Missense_Mutation	SNP	G	G	A	rs147583558		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:35800939G>A	uc002nyy.1	+	8	1543	c.1394G>A	c.(1393-1395)CGC>CAC	p.R465H	MAG_uc002nyx.1_Missense_Mutation_p.R465H|MAG_uc010eds.1_Missense_Mutation_p.R440H|MAG_uc002nyz.1_Missense_Mutation_p.R465H	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	465	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TACTCGGAGCGCAGCGGCCTC	0.677		NA											36	64					0	0	0	0
CPT1C	126129	broad.mit.edu	37	19	50216294	50216294	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:50216294C>G	uc002ppj.2	+	18	2404	c.2199C>G	c.(2197-2199)ATC>ATG	p.I733M	CPT1C_uc002ppi.2_Missense_Mutation_p.I650M|CPT1C_uc002ppk.2_Missense_Mutation_p.I722M|CPT1C_uc010eng.2_Missense_Mutation_p.I733M|CPT1C_uc010enh.2_Missense_Mutation_p.I733M|CPT1C_uc010eni.1_Missense_Mutation_p.I301M	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	733	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTTCCACATCTCCAGCAAAA	0.313		NA											121	214					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50720993	50720993	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:50720993C>A	uc002prr.1	+	3	574	c.527C>A	c.(526-528)GCA>GAA	p.A176E	MYH14_uc010enu.1_Missense_Mutation_p.A176E|MYH14_uc002prq.1_Missense_Mutation_p.A176E	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	176	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CACGTGTACGCAGTGACCGAG	0.637		NA											42	71					2.56e-15	2.94e-15	1	0
ZNF845	91664	broad.mit.edu	37	19	53856710	53856710	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:53856710T>G	uc010ydv.1	+	4	2899	c.2782T>G	c.(2782-2784)TCA>GCA	p.S928A	ZNF845_uc010ydw.1_Missense_Mutation_p.S928A	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	928	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGTCACAATTCAGTCCTTGT	0.373		NA											14	21					0	0	0	0
YWHAQ	10971	broad.mit.edu	37	2	9770492	9770492	+	Silent	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:9770492G>C	uc002qzw.2	-	1	254	c.90C>G	c.(88-90)ACC>ACG	p.T30T	YWHAQ_uc002qzx.2_Silent_p.T30T	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	30					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		CGCCCTGCTCGGTCACTGCCT	0.607		NA											25	28					0	0	0	0
REG1B	5968	broad.mit.edu	37	2	79313560	79313560	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:79313560G>T	uc002sny.2	-	4	366	c.254C>A	c.(253-255)GCC>GAC	p.A85D	REG1B_uc010ffv.1_Missense_Mutation_p.A85D|REG1B_uc010ffw.2_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	85	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						AATCAGTGAGGCCACGAAGGC	0.502		NA											56	66					2.54e-28	2.97e-28	1	0
ACTR1B	10120	broad.mit.edu	37	2	98274472	98274472	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:98274472C>T	uc002syb.2	-	8	1067	c.859G>A	c.(859-861)GAC>AAC	p.D287N		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	287						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						AGGTCCATGTCGGACTTGTGT	0.607		NA											5	128					0	0	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026403	129026403	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:129026403C>G	uc002tpt.3	-	2	603	c.569G>C	c.(568-570)CGC>CCC	p.R190P		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	190	Lumenal (Potential).|3'-phosphate binding (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		GCTCAGGTAGCGGGACACGGG	0.642		NA											19	53					0	0	0	0
GMPPA	29926	broad.mit.edu	37	2	220368880	220368880	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:220368880G>A	uc002vlr.2	+	7	633	c.565G>A	c.(565-567)GAA>AAA	p.E189K	GMPPA_uc002vls.2_Missense_Mutation_p.E189K|GMPPA_uc002vlt.2_Missense_Mutation_p.E189K|GMPPA_uc002vlu.2_Missense_Mutation_p.E189K|GMPPA_uc002vlv.2_Missense_Mutation_p.E189K|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.E189K	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	189					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CTTTTCTCCTGAAGCCTTGAA	0.527		NA											5	128					0	0	0	0
HTR2B	3357	broad.mit.edu	37	2	231973477	231973477	+	Silent	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:231973477C>A	uc002vro.2	-	4	1705	c.1200G>T	c.(1198-1200)CGG>CGT	p.R400R	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Silent_p.R333R	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	400	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	ACTTTGTGGCCCGGTAATTGC	0.428		NA											4	147					0.00909568	0.00957055	1	0
ADAM33	80332	broad.mit.edu	37	20	3652265	3652265	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:3652265C>T	uc002wit.2	-	16	1955	c.1868G>A	c.(1867-1869)GGC>GAC	p.G623D	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.G623D|ADAM33_uc002wis.2_Missense_Mutation_p.G145D|ADAM33_uc002wiu.2_Missense_Mutation_p.G623D|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Missense_Mutation_p.G139D	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	623	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CTCTACCAGGCCCAGGCCAAG	0.632		NA											3	29					0	0	0	0
CDC25B	994	broad.mit.edu	37	20	3781917	3781917	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:3781917G>A	uc002wjn.2	+	8	1500	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	CDC25B_uc010zqk.1_Missense_Mutation_p.R177Q|CDC25B_uc010zql.1_Missense_Mutation_p.R163Q|CDC25B_uc010zqm.1_Missense_Mutation_p.R177Q|CDC25B_uc002wjl.2_Missense_Mutation_p.R129Q|CDC25B_uc002wjm.2_Missense_Mutation_p.R129Q|CDC25B_uc002wjo.2_Missense_Mutation_p.R227Q|CDC25B_uc002wjp.2_Missense_Mutation_p.R200Q|CDC25B_uc002wjq.2_Missense_Mutation_p.R41Q|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	241					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						AGTCCTGACCGGAAGATGGAA	0.562		NA											5	238					0	0	0	0
HAO1	54363	broad.mit.edu	37	20	7920988	7920988	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:7920988T>C	uc002wmw.1	-	1	106	c.82A>G	c.(82-84)AGG>GGG	p.R28G	HAO1_uc010gbu.2_Missense_Mutation_p.R28G	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	28	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCCCAGACCTGTAATAGTCA	0.313		NA											3	186					0	0	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784277	30784277	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:30784277C>T	uc002wxn.2	-	3	1686	c.1469G>A	c.(1468-1470)CGT>CAT	p.R490H		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	490						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGATGGAAACGAGGCAGGGT	0.577		NA											20	142					0	0	0	0
PRPF6	24148	broad.mit.edu	37	20	62660835	62660835	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:62660835C>T	uc002yho.2	+	19	2705	c.2537C>T	c.(2536-2538)GCC>GTC	p.A846V	PRPF6_uc002yhp.2_Missense_Mutation_p.A806V	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	846					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GTGCTCCTGGCCGTGGCCAAG	0.587		NA											4	187					0	0	0	0
TRIOBP	11078	broad.mit.edu	37	22	38154082	38154082	+	Silent	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr22:38154082C>G	uc003atr.2	+	16	6421	c.6150C>G	c.(6148-6150)CTC>CTG	p.L2050L	TRIOBP_uc003atu.2_Silent_p.L1878L|TRIOBP_uc003atv.2_Silent_p.L337L|TRIOBP_uc003atw.2_Silent_p.L337L|TRIOBP_uc003atx.1_5'UTR|TRIOBP_uc010gxh.2_5'UTR	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	2050					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGCCCTGCTCAACCAAAGCC	0.642		NA											10	16					0	0	0	0
NCAPH2	29781	broad.mit.edu	37	22	50961570	50961570	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr22:50961570G>C	uc003blr.3	+	19	1774	c.1652G>C	c.(1651-1653)CGT>CCT	p.R551P	NCAPH2_uc003blv.2_Missense_Mutation_p.R551P|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.R552P|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	551					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GAGGTGTGTCGTTCCATGCTG	0.647		NA											10	14					0	0	0	0
FGD5	152273	broad.mit.edu	37	3	14960293	14960293	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:14960293C>A	uc003bzc.2	+	13	3632	c.3522C>A	c.(3520-3522)TAC>TAA	p.Y1174*	FGD5_uc011avk.1_Nonsense_Mutation_p.Y1174*|FGD5_uc003bzd.2_Nonsense_Mutation_p.Y252*	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1174	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AAGTGCCCTACGCTCTAAAGA	0.602		NA											19	9					3.6e-14	4.1e-14	1	0
KIAA1524	57650	broad.mit.edu	37	3	108285471	108285471	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:108285471C>A	uc003dxb.3	-	11	1557	c.1288G>T	c.(1288-1290)GAT>TAT	p.D430Y	KIAA1524_uc010hpv.1_5'UTR	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	430						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTTAGTGTATCATCTCCACAG	0.303		NA											4	172					0.00909568	0.00957055	1	0
GK5	256356	broad.mit.edu	37	3	141884548	141884548	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:141884548C>A	uc003euq.1	-	16	1637	c.1506G>T	c.(1504-1506)CAG>CAT	p.Q502H	GK5_uc003eup.1_Missense_Mutation_p.Q223H|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	502					glycerol metabolic process		ATP binding|glycerol kinase activity				0						GACATTTCTTCTGTGGCTTGA	0.353		NA											87	209					9.18e-55	1.08e-54	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			41	85					0	0	0	0
EIF2B5	8893	broad.mit.edu	37	3	183855991	183855991	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:183855991G>A	uc003fmp.2	+	5	1086	c.722G>A	c.(721-723)CGA>CAA	p.R241Q	EIF2B5_uc003fmq.2_5'UTR	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	241					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTGGAGGTTCGATATGATTTA	0.483		NA											46	117					0	0	0	0
IL1RAP	3556	broad.mit.edu	37	3	190366168	190366168	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:190366168C>T	uc003fsm.1	+	12	1593	c.1387C>T	c.(1387-1389)CGC>TGC	p.R463C	IL1RAP_uc010hzg.1_Missense_Mutation_p.R463C|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.R463C|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	463	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		GAAAAGCAGACGCCTCCTGGT	0.502		NA											120	343					0	0	0	0
HRASLS	57110	broad.mit.edu	37	3	192980878	192980878	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:192980878G>C	uc003fta.2	+	3	664	c.259G>C	c.(259-261)GAT>CAT	p.D87H		NM_020386	NP_065119	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	87											0	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CAATAAATACGATGAAACGTA	0.433		NA											78	203					0	0	0	0
EVC2	132884	broad.mit.edu	37	4	5664846	5664846	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:5664846T>G	uc003gij.2	-	9	1187	c.1133A>C	c.(1132-1134)CAA>CCA	p.Q378P	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.Q298P	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	378						integral to membrane				large_intestine(3)|ovary(2)	5						TTCTAAGGCTTGAAGCATGCT	0.428		NA											37	133					0	0	0	0
CD38	952	broad.mit.edu	37	4	15818249	15818249	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:15818249G>A	uc011bxc.1	+	2	456	c.349G>A	c.(349-351)GTA>ATA	p.V117I	CD38_uc003goj.1_Missense_Mutation_p.V117I|CD38_uc003gol.1_Missense_Mutation_p.V117I	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	117	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						AACTCAGACCGTACCTTGCAA	0.378		NA											4	152					0	0	0	0
PTPN13	5783	broad.mit.edu	37	4	87653773	87653773	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:87653773G>A	uc003hpz.2	+	12	2192	c.1712G>A	c.(1711-1713)CGA>CAA	p.R571Q	PTPN13_uc003hpy.2_Missense_Mutation_p.R571Q|PTPN13_uc003hqa.2_Missense_Mutation_p.R571Q|PTPN13_uc003hqb.2_Missense_Mutation_p.R571Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	571						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GAGGATAACCGAAGGAAAGTA	0.328		NA											30	68					0	0	0	0
PKD2	5311	broad.mit.edu	37	4	88973183	88973183	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:88973183C>G	uc003hre.2	+	7	1655	c.1589C>G	c.(1588-1590)TCA>TGA	p.S530*	PKD2_uc011cdf.1_Translation_Start_Site|PKD2_uc011cdg.1_Translation_Start_Site|PKD2_uc011cdh.1_Translation_Start_Site	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	530	Extracellular (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TACAGAACATCAAATGTGGAG	0.333		NA											18	80					0	0	0	0
PHF17	79960	broad.mit.edu	37	4	129792809	129792809	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:129792809C>T	uc003igk.2	+	11	2201	c.1921C>T	c.(1921-1923)CGT>TGT	p.R641C	PHF17_uc003igl.2_Missense_Mutation_p.R629C|PHF17_uc011cgy.1_Missense_Mutation_p.R641C	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	641					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						TGCAGAAGCACGTCTCATATC	0.458		NA											42	70					0	0	0	0
ASB5	140458	broad.mit.edu	37	4	177142616	177142616	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:177142616C>T	uc003iuq.1	-	4	536	c.520G>A	c.(520-522)GAG>AAG	p.E174K	ASB5_uc003iup.1_Missense_Mutation_p.E121K	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	174	ANK 4.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CTGGCGGCCTCATGCGTTGGG	0.488		NA											68	106					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13871017	13871017	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:13871017G>A	uc003jfd.2	-	24	3735	c.3693C>T	c.(3691-3693)AAC>AAT	p.N1231N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1231	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCATAAAAATGTTTTCCATCT	0.408		NA							Kartagener_syndrome				37	191					0	0	0	0
FNIP1	96459	broad.mit.edu	37	5	130987626	130987626	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:130987626C>G	uc003kvs.1	-	16	3317	c.3175G>C	c.(3175-3177)GTT>CTT	p.V1059L	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.V1031L	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	1059					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		GCCACTTGAACAGTCCATTTA	0.383		NA											30	67					0	0	0	0
SLC22A5	6584	broad.mit.edu	37	5	131721136	131721136	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:131721136C>T	uc003kww.3	+	4	1033	c.769C>T	c.(769-771)CGG>TGG	p.R257W	SLC22A5_uc003kwx.3_Missense_Mutation_p.R281W|SLC22A5_uc010jdr.1_5'UTR	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	257	Extracellular (Potential).		R -> W (in CDSP).		positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCGAGACTGGCGGATGCTGCT	0.522		NA									OREG0016766	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	87					0	0	0	0
FSTL4	23105	broad.mit.edu	37	5	132736645	132736645	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:132736645C>A	uc003kyn.1	-	4	412	c.194G>T	c.(193-195)TGC>TTC	p.C65F		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	65						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTCTTCCCGCAGGAGGCCAG	0.627		NA											12	26					3.27e-08	3.67e-08	1	0
DOCK2	1794	broad.mit.edu	37	5	169508958	169508958	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:169508958G>A	uc003maf.2	+	51	5480	c.5400G>A	c.(5398-5400)CGG>CGA	p.R1800R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.R1292R|DOCK2_uc003mah.2_Silent_p.R356R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1800					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACTCACACGGAAGAAGGTCA	0.527		NA											31	49					0	0	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104203	26104203	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:26104203G>C	uc003ngi.2	+	1	28	c.28G>C	c.(28-30)GGC>CGC	p.G10R		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	10					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGGCGGAAAAGGCTTGGGGAA	0.527		NA											33	67					0	0	0	0
KIAA0776	23376	broad.mit.edu	37	6	96990812	96990812	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:96990812G>A	uc003por.2	+	12	1370	c.1322G>A	c.(1321-1323)AGA>AAA	p.R441K	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	441					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		GGCAATGCCAGAGAGTACAAA	0.378		NA											37	53					0	0	0	0
RBM16	22828	broad.mit.edu	37	6	155145427	155145427	+	Silent	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:155145427G>A	uc003qqa.2	+	18	2218	c.1986G>A	c.(1984-1986)TCG>TCA	p.S662S	RBM16_uc011efj.1_Silent_p.S728S|RBM16_uc011efk.1_Silent_p.S707S|RBM16_uc003qpz.2_Silent_p.S662S|RBM16_uc010kji.2_Silent_p.S683S	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	662	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TTCCTGTGTCGATGCCGGTTC	0.458		NA											89	202					0	0	0	0
SLC29A4	222962	broad.mit.edu	37	7	5338650	5338650	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:5338650A>G	uc003sod.2	+	8	1075	c.914A>G	c.(913-915)GAG>GGG	p.E305G	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.E305G|SLC29A4_uc003soe.2_Missense_Mutation_p.E291G|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	305	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCCCCCAACGAGTCCCCAAAG	0.692		NA											4	45					0	0	0	0
GLI3	2737	broad.mit.edu	37	7	42005532	42005532	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:42005532G>T	uc011kbh.1	-	15	3230	c.3139C>A	c.(3139-3141)CAG>AAG	p.Q1047K	GLI3_uc011kbg.1_Missense_Mutation_p.Q988K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1047					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GTGTAATTCTGAAGCACGAGA	0.672		NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				16	22					1.15e-07	1.28e-07	1	0
CLDN15	24146	broad.mit.edu	37	7	100877667	100877667	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:100877667C>T	uc003uyg.1	-	2	528	c.274G>A	c.(274-276)GGC>AGC	p.G92S	CLDN15_uc003uyh.1_Missense_Mutation_p.G92S|CLDN15_uc003uyi.2_3'UTR	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15	92	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					AGCAAGAGGCCGAGGAAGCCC	0.647		NA											27	71					0	0	0	0
OR2F1	26211	broad.mit.edu	37	7	143657530	143657530	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:143657530C>G	uc003wds.1	+	1	511	c.467C>G	c.(466-468)TCT>TGT	p.S156C		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TTCATCAGCTCTCCTGTGCAG	0.522		NA											38	68					0	0	0	0
OR2A7	401427	broad.mit.edu	37	7	143956023	143956023	+	Silent	SNP	C	C	T			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:143956023C>T	uc011kuc.1	-	1	699	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	OR2A9P_uc003wec.1_Intron|uc003wed.2_5'Flank	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					AGGCTTTCCTCTGAACTTCCC	0.483		NA											47	268					0	0	0	0
C9orf131	138724	broad.mit.edu	37	9	35044336	35044336	+	Silent	SNP	G	G	A	rs115027328	by1000genomes	TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:35044336G>A	uc003zvw.2	+	2	1739	c.1710G>A	c.(1708-1710)CCG>CCA	p.P570P	C9orf131_uc003zvu.2_Silent_p.P522P|C9orf131_uc003zvv.2_Silent_p.P497P|C9orf131_uc003zvx.2_Silent_p.P535P	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	570											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCTTGCACCGGAGCTGCTCA	0.527		NA											4	264					0	0	0	0
FAM120A	23196	broad.mit.edu	37	9	96291641	96291641	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:96291641G>A	uc004atw.2	+	9	1538	c.1513G>A	c.(1513-1515)GGC>AGC	p.G505S	FAM120A_uc004atv.2_Missense_Mutation_p.G505S|FAM120A_uc004atx.2_Missense_Mutation_p.G287S|FAM120A_uc004aty.2_Missense_Mutation_p.G286S|FAM120A_uc004atz.2_Missense_Mutation_p.G154S|FAM120A_uc010mrf.1_RNA|FAM120A_uc010mrg.2_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	505						cytoplasm|plasma membrane	RNA binding				0						GTAGGCAGAAGGCTCGTCCAC	0.537		NA											33	37					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139402754	139402754	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:139402754G>C	uc004chz.2	-	20	3255	c.3255C>G	c.(3253-3255)TGC>TGG	p.C1085W	NOTCH1_uc004cia.1_Missense_Mutation_p.C315W	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1085	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGCCGCTGGGGCACTCGCAGC	0.652		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			36	65					0	0	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411520	23411520	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chrX:23411520G>A	uc004dal.3	+	3	1893	c.1885G>A	c.(1885-1887)GAC>AAC	p.D629N		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	629					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TTTTCAAGAGGACATCATCTT	0.398		NA											37	64					0	0	0	0
B2M	567	broad.mit.edu	37	15	45003781	45003782	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr15:45003781_45003782delCT	uc001zuc.2	+	1	97_98	c.37_38delCT	c.(37-39)CTCfs	p.L13fs	B2M_uc010uek.1_Frame_Shift_Del_p.L13fs|B2M_uc010bdx.1_Frame_Shift_Del_p.L13fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	13					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GCTCGCGCTACTCTCTCTTTCT	0.614		NA											31	26	---	---	---	---	NA	NA	NA	NA
ZNF221	7638	broad.mit.edu	37	19	44470025	44470025	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:44470025delA	uc002oxx.2	+	6	699	c.371delA	c.(370-372)CAAfs	p.Q124fs	ZNF221_uc010ejb.1_Frame_Shift_Del_p.Q124fs|ZNF221_uc010xws.1_Frame_Shift_Del_p.Q124fs	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				TCCTGTCAGCAAATATGGGAA	0.443		NA											47	112	---	---	---	---	NA	NA	NA	NA
