Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
FBXO44	93611	broad.mit.edu	37	1	11718436	11718436	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:11718436C>T	uc001asm.2	+	3	504	c.378C>T	c.(376-378)TTC>TTT	p.F126F	FBXO44_uc001ask.2_Intron|FBXO44_uc010oaq.1_Silent_p.F126F|FBXO44_uc001asl.2_Silent_p.F126F|FBXO44_uc001asn.2_Intron|FBXO44_uc010oar.1_Intron|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	126	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		AGAAATACTTCGTTACTTCAT	0.527		NA											28	81					0	0	0	0
LOC440563	440563	broad.mit.edu	37	1	13183780	13183780	+	Silent	SNP	A	A	C	rs116484938	by1000genomes	TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:13183780A>C	uc010obg.1	-	1	188	c.93T>G	c.(91-93)TCT>TCG	p.S31S		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	31						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CCTCCACATCAGATTTCTTGA	0.468		NA											7	68					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418		NA											5	70					0	0	0	0
JAK1	3716	broad.mit.edu	37	1	65332750	65332750	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:65332750C>T	uc001dbu.1	-	7	1038	c.789G>A	c.(787-789)ACG>ACA	p.T263T	JAK1_uc009wam.1_Silent_p.T251T	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	263	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCAGGTCATGCGTGGACACGC	0.398		NA	Mis		ALL								4	144					0	0	0	0
CSF1	1435	broad.mit.edu	37	1	110466699	110466699	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:110466699G>A	uc001dyu.2	+	6	1869	c.1456G>A	c.(1456-1458)GAG>AAG	p.E486K	CSF1_uc001dyt.2_Missense_Mutation_p.E370K|CSF1_uc001dyv.3_Missense_Mutation_p.E188K|CSF1_uc001dyw.3_Missense_Mutation_p.E486K	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	486	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGGCAGTCCGAGGGATCCTT	0.612		NA											20	61					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152188507	152188507	+	Silent	SNP	A	A	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:152188507A>T	uc001ezt.1	-	3	5674	c.5598T>A	c.(5596-5598)GGT>GGA	p.G1866G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1866	20				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAAGACTGACCTGAGCCAG	0.582		NA											38	667					0	0	0	0
TRIM46	80128	broad.mit.edu	37	1	155152367	155152367	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:155152367C>T	uc001fhs.1	+	8	1628	c.1545C>T	c.(1543-1545)GGC>GGT	p.G515G	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Silent_p.G515G|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.G389G|TRIM46_uc001fhu.1_Silent_p.G492G|TRIM46_uc009wpg.1_Silent_p.G502G|TRIM46_uc001fhv.3_Silent_p.G502G|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	515	Fibronectin type-III.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCGGCTACGGCGAATACAGTG	0.657		NA											8	25					0	0	0	0
ISG20L2	81875	broad.mit.edu	37	1	156696882	156696882	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:156696882C>T	uc001fps.1	-	1	824	c.563G>A	c.(562-564)GGC>GAC	p.G188D	ISG20L2_uc001fpt.1_Missense_Mutation_p.G188D|C1orf66_uc001fpu.2_5'Flank|C1orf66_uc001fpv.2_5'Flank	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	188	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGTCCTGTGCCCACCATCTC	0.517		NA									OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	164					0	0	0	0
FAM58B	339521	broad.mit.edu	37	1	200183318	200183318	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:200183318C>T	uc009wzi.1	+	1	663	c.627C>T	c.(625-627)GTC>GTT	p.V209V		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	209					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TCTATGGAGTCGAGGTGCCCG	0.597		NA											7	39					0	0	0	0
DYDC2	84332	broad.mit.edu	37	10	82126495	82126495	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:82126495G>A	uc001kca.1	+	5	702	c.322G>A	c.(322-324)GAC>AAC	p.D108N	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Missense_Mutation_p.D108N	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	108							protein binding				0			Colorectal(32;0.229)			CATGCAGGAGGACACAAACCC	0.438		NA											4	147					0	0	0	0
WAPAL	23063	broad.mit.edu	37	10	88277386	88277386	+	Silent	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:88277386T>C	uc001kdo.2	-	2	883	c.441A>G	c.(439-441)ACA>ACG	p.T147T	WAPAL_uc001kdn.2_Silent_p.T190T|WAPAL_uc009xsw.2_Silent_p.T147T|WAPAL_uc010qmh.1_Silent_p.T147T|WAPAL_uc010qmi.1_Silent_p.T184T|WAPAL_uc010qmj.1_Silent_p.T147T	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	147	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CAATTCGGTTTGTGCTCTTTT	0.363		NA											3	76					0	0	0	0
FAM178A	55719	broad.mit.edu	37	10	102689617	102689617	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:102689617T>G	uc001krt.3	+	8	2738	c.2196T>G	c.(2194-2196)ATT>ATG	p.I732M	FAM178A_uc001krs.2_Missense_Mutation_p.I732M	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	732											0						CAGTTACAATTGATGCTATTC	0.294		NA											12	56					0	0	0	0
KNDC1	85442	broad.mit.edu	37	10	135015084	135015084	+	Silent	SNP	C	C	T	rs142572566		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:135015084C>T	uc001llz.1	+	17	3070	c.3069C>T	c.(3067-3069)GAC>GAT	p.D1023D	KNDC1_uc001lma.1_Silent_p.D958D|KNDC1_uc001lmb.1_Silent_p.D435D	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1023					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGGACTCGGACGCACTGTCAC	0.627		NA											13	55					0	0	0	0
C11orf46	120534	broad.mit.edu	37	11	30358279	30358279	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:30358279G>T	uc001mso.1	+	4	884	c.720G>T	c.(718-720)AAG>AAT	p.K240N	C11orf46_uc001msp.2_5'Flank	NM_152316	NP_689529	Q8N8R7	CK046_HUMAN	hypothetical protein LOC120534	240											0						GTGACCGCAAGTGGCTGTATG	0.443		NA											16	100					1.03e-11	1.13e-11	1	0
PRG2	5553	broad.mit.edu	37	11	57154973	57154973	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:57154973C>A	uc001njz.2	-	5	671	c.644G>T	c.(643-645)AGA>ATA	p.R215I	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.R215I|PRG2_uc001nkb.2_Missense_Mutation_p.R215I|PRG2_uc001nkd.2_Missense_Mutation_p.R204I|PRG2_uc001nkc.2_Missense_Mutation_p.R215I|PRG2_uc001nke.2_Missense_Mutation_p.R495I	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	215	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	GAAAGGAAGTCTTCTGAGGCA	0.602		NA											9	44					3.1e-07	3.39e-07	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42866219	42866219	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:42866219C>T	uc010skv.1	-	2	387	c.100G>A	c.(100-102)GCC>ACC	p.A34T	PRICKLE1_uc001rnl.2_Missense_Mutation_p.A34T|PRICKLE1_uc010skw.1_Missense_Mutation_p.A34T|PRICKLE1_uc001rnm.2_Missense_Mutation_p.A34T|PRICKLE1_uc009zka.2_Missense_Mutation_p.A30T	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	34	PET.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GGGACCCAGGCGTACTCCTCC	0.478		NA											11	43					0	0	0	0
PA2G4	5036	broad.mit.edu	37	12	56504766	56504766	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56504766G>C	uc001sjm.2	+	10	1280	c.861G>C	c.(859-861)AAG>AAC	p.K287N	PA2G4_uc009zol.2_Missense_Mutation_p.K287N|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	287					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AAGATGAGAAGAAGGCTCGGA	0.428		NA											7	39					0	0	0	0
PA2G4	5036	broad.mit.edu	37	12	56505295	56505295	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56505295G>C	uc001sjm.2	+	12	1520	c.1101G>C	c.(1099-1101)CAG>CAC	p.Q367H	PA2G4_uc009zol.2_Intron|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	367	Necessary for nucleolar localization.|Interaction with RNA (By similarity).				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GAAAAACCCAGAAAAAGAAAA	0.393		NA											22	104					0	0	0	0
CHST11	50515	broad.mit.edu	37	12	105151235	105151235	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:105151235A>G	uc001tkx.1	+	4	1004	c.713A>G	c.(712-714)GAG>GGG	p.E238G	CHST11_uc001tky.2_Missense_Mutation_p.E233G|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	238	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						GTCAAATTCGAGGAGTTTGTG	0.567		NA											20	57					0	0	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:113515335T>G	uc001tuk.1	+	2	702	c.366T>G	c.(364-366)GAT>GAG	p.D122E		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CGGCCTACGATATGGACATCT	0.622		NA											4	46					0	0	0	0
PABPC3	5042	broad.mit.edu	37	13	25670487	25670487	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr13:25670487T>C	uc001upy.2	+	1	212	c.151T>C	c.(151-153)TCC>CCC	p.S51P		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	51	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CACCAGCGGCTCCTCCAACTA	0.562		NA											12	53					0	0	0	0
NID2	22795	broad.mit.edu	37	14	52473375	52473375	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr14:52473375G>A	uc001wzo.2	-	20	4118	c.3884C>T	c.(3883-3885)ACC>ATC	p.T1295I	NID2_uc010tqs.1_Missense_Mutation_p.T1247I|NID2_uc010tqt.1_Missense_Mutation_p.T1295I	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1295	LDL-receptor class B 4.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CAGTTTTTTGGTTCCTTTTAA	0.428		NA											13	90					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	34150099	34150099	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:34150099G>A	uc001zhi.2	+	99	14196	c.14126G>A	c.(14125-14127)TGC>TAC	p.C4709Y	RYR3_uc010bar.2_Missense_Mutation_p.C4704Y	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4709				C -> R (in Ref. 6; CAA52326).	cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATATGAAGTGCGACGACATG	0.592		NA											6	41					0	0	0	0
VPS18	57617	broad.mit.edu	37	15	41191580	41191580	+	Silent	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:41191580C>G	uc001zne.2	+	4	903	c.564C>G	c.(562-564)CTC>CTG	p.L188L		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	188					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTCCGGATCTCTACTTCCGCC	0.602		NA											14	72					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43816968	43816968	+	Silent	SNP	C	C	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:43816968C>A	uc001zrt.2	+	4	3764	c.3297C>A	c.(3295-3297)GTC>GTA	p.V1099V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1099						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGCAATAGTCTTTGAGATTA	0.547		NA											18	76					4.54e-19	5.08e-19	1	0
LRRK1	79705	broad.mit.edu	37	15	101589973	101589973	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:101589973G>A	uc002bwr.2	+	23	3743	c.3424G>A	c.(3424-3426)GAT>AAT	p.D1142N	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1142					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCTTGATTGATCAGTGGTT	0.463		NA											11	43					0	0	0	0
TPSD1	23430	broad.mit.edu	37	16	1306807	1306807	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr16:1306807G>C	uc002clb.1	+	3	273	c.264G>C	c.(262-264)AAG>AAC	p.K88N	TPSD1_uc010brm.1_Intron	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	88	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGACATCAAGGATCTGGCCG	0.667		NA											3	25					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18057108	18057108	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:18057108G>A	uc010vxh.1	+	42	8324	c.7986G>A	c.(7984-7986)CTG>CTA	p.L2662L	MYO15A_uc010vxi.1_5'UTR|MYO15A_uc010vxj.1_5'Flank|MYO15A_uc010vxk.1_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2662	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CGCGATCGCTGGAGCCCCCTG	0.512		NA											4	33					0	0	0	0
TANC2	26115	broad.mit.edu	37	17	61391920	61391920	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:61391920G>A	uc002jal.3	+	8	1132	c.1109G>A	c.(1108-1110)GGA>GAA	p.G370E	TANC2_uc010wpe.1_Missense_Mutation_p.G280E	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	370							binding			ovary(2)	2						GTGATTGTGGGAAACATTGGA	0.498		NA											21	90					0	0	0	0
FASN	2194	broad.mit.edu	37	17	80045301	80045301	+	Silent	SNP	C	C	T	rs146226779		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:80045301C>T	uc002kdu.2	-	20	3240	c.3123G>A	c.(3121-3123)TCG>TCA	p.S1041S	FASN_uc002kdw.1_Silent_p.S257S	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1041					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGTGCTTGGCCGAGCCCAGGA	0.622		NA											10	50					0	0	0	0
LRRC30	339291	broad.mit.edu	37	18	7231177	7231177	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:7231177G>A	uc010wzk.1	+	1	41	c.41G>A	c.(40-42)GGC>GAC	p.G14D		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	14										ovary(1)|liver(1)	2						AAGGATAAGGGCCCCAAGAGG	0.632		NA											11	73					0	0	0	0
MPPE1	65258	broad.mit.edu	37	18	11893497	11893497	+	Silent	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:11893497G>T	uc002kqf.2	-	4	1001	c.360C>A	c.(358-360)ATC>ATA	p.I120I	MPPE1_uc002kqn.2_Silent_p.I120I|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Silent_p.I120I|MPPE1_uc002kqk.2_Silent_p.I120I|MPPE1_uc002kql.2_Silent_p.I120I|MPPE1_uc002kqm.2_Silent_p.I120I|MPPE1_uc010dla.1_Silent_p.I120I	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	120					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						CTTCATCAAAGATATCCCCCA	0.537		NA											17	32					1.56e-12	1.74e-12	1	0
CYP4F12	66002	broad.mit.edu	37	19	15807840	15807840	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:15807840G>A	uc002nbl.2	+	13	1581	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TTGATCATGCGCGCCGAGGGC	0.562		NA											9	41					0	0	0	0
GNG8	94235	broad.mit.edu	37	19	47137457	47137457	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:47137457G>T	uc010xyd.1	-	2	89	c.89C>A	c.(88-90)TCG>TAG	p.S30*		NM_033258	NP_150283	Q9UK08	GBG8_HUMAN	guanine nucleotide binding protein (G protein),	30					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.000621)|Epithelial(262;0.0171)|GBM - Glioblastoma multiforme(486;0.0325)		TGCTGCCTGCGACACCTGCGA	0.677		NA											6	11					0.00198382	0.00211806	1	0
GRIN2D	2906	broad.mit.edu	37	19	48922614	48922614	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:48922614A>G	uc002pjc.3	+	8	1947	c.1859A>G	c.(1858-1860)AAG>AGG	p.K620R	GRIN2D_uc010elx.2_5'UTR	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	620	Cytoplasmic (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCCACGGGCAAGCGTGAGTCC	0.597		NA											7	31					0	0	0	0
ZNF543	125919	broad.mit.edu	37	19	57838010	57838010	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:57838010T>C	uc002qoi.1	+	3	500	c.155T>C	c.(154-156)TTG>TCG	p.L52S		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGCTGTCCTTTGTTCAAACCA	0.493		NA											10	51					0	0	0	0
RASGRP3	25780	broad.mit.edu	37	2	33764264	33764264	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr2:33764264G>T	uc002rox.2	+	13	1892	c.1265G>T	c.(1264-1266)AGG>ATG	p.R422M	RASGRP3_uc010ync.1_Missense_Mutation_p.R422M|RASGRP3_uc002roy.2_Missense_Mutation_p.R421M	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	422	EF-hand 1.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					AAGCACATAAGGAAATTAGTG	0.517		NA											3	10					0.00909568	0.00956731	1	0
LOC728819	728819	broad.mit.edu	37	2	43902588	43902588	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr2:43902588G>A	uc010fav.1	-	1	874	c.874C>T	c.(874-876)CGG>TGG	p.R292W	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCCCTGAGCCGGTACAGGCCA	0.453		NA											4	51					0	0	0	0
CHODL	140578	broad.mit.edu	37	21	19628972	19628972	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr21:19628972G>C	uc002ykv.2	+	2	617	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	CHODL_uc002ykr.2_Missense_Mutation_p.E35Q|CHODL_uc002yks.2_Missense_Mutation_p.E35Q|CHODL_uc002ykt.2_Missense_Mutation_p.E35Q|CHODL_uc002yku.2_Missense_Mutation_p.E35Q	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	76	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GAATGAAGCAGAACAGAAGTT	0.512		NA											19	79					0	0	0	0
PRODH	5625	broad.mit.edu	37	22	18906002	18906002	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:18906002A>C	uc010grl.2	-	11	1268	c.1254T>G	c.(1252-1254)GAT>GAG	p.D418E	PRODH_uc002zoj.3_Missense_Mutation_p.D308E|PRODH_uc002zol.3_Missense_Mutation_p.D308E|PRODH_uc002zok.3_Missense_Mutation_p.D418E	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	418					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	TGTCATAGGCATCCTGTGGGG	0.662		NA											3	21					0	0	0	0
RGL4	266747	broad.mit.edu	37	22	24038844	24038844	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:24038844G>A	uc002zxn.2	+	7	2300	c.1130G>A	c.(1129-1131)AGA>AAA	p.R377K	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.R377K|RGL4_uc002zxp.1_Missense_Mutation_p.R241K|RGL4_uc002zxq.2_Missense_Mutation_p.R241K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	377	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						AACCCCCAGAGAGTCCAGATG	0.652		NA											7	26					0	0	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962716	37962716	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:37962716C>G	uc003asz.3	+	2	763	c.360C>G	c.(358-360)ATC>ATG	p.I120M		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	120					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					AGAACGCCATCTCCCTGCCCC	0.692		NA											16	82					0	0	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115677	15115677	+	Missense_Mutation	SNP	C	C	T	rs147577833	byFrequency	TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:15115677C>T	uc003bzm.1	-	14	2581	c.1967G>A	c.(1966-1968)CGC>CAC	p.R656H	ZFYVE20_uc010hek.1_Missense_Mutation_p.R656H	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	656	Necessary for the interaction with RAB5A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TTTCAGGATGCGGGCTGAAGG	0.562		NA											4	102					0	0	0	0
UBA3	9039	broad.mit.edu	37	3	69111272	69111272	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:69111272T>A	uc003dno.2	-	10	772	c.752A>T	c.(751-753)GAG>GTG	p.E251V	UBA3_uc003dnq.2_Missense_Mutation_p.E237V|UBA3_uc011bfy.1_Missense_Mutation_p.E74V|UBA3_uc011bfz.1_Missense_Mutation_p.E74V	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	251					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		CCTTACATACTCAATACAGTG	0.343		NA											20	74					0	0	0	0
POLQ	10721	broad.mit.edu	37	3	121208235	121208235	+	Silent	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:121208235A>G	uc003eee.3	-	16	3672	c.3543T>C	c.(3541-3543)AAT>AAC	p.N1181N	POLQ_uc003eed.2_Silent_p.N353N	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1181					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TCATATAAACATTCTGGTTTT	0.378		NA						DNA_polymerases_(catalytic_subunits)					7	204					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124103747	124103747	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:124103747C>T	uc003ehg.2	+	11	1947	c.1820C>T	c.(1819-1821)ACG>ATG	p.T607M	KALRN_uc010hrv.1_Missense_Mutation_p.T607M|KALRN_uc003ehf.1_Missense_Mutation_p.T607M|KALRN_uc011bjy.1_Missense_Mutation_p.T607M|KALRN_uc003ehh.1_Translation_Start_Site	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	607	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTGGCTCAGACGGGGGAATGT	0.577		NA											7	53					0	0	0	0
NCK1	4690	broad.mit.edu	37	3	136664745	136664745	+	Missense_Mutation	SNP	G	G	A	rs149750260		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:136664745G>A	uc003erh.2	+	3	654	c.547G>A	c.(547-549)GTC>ATC	p.V183I	NCK1_uc011bme.1_Missense_Mutation_p.V119I	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	183					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						AGCAGCAGTCGTCAATAACCT	0.428		NA											27	114					0	0	0	0
TUBB4Q	56604	broad.mit.edu	37	4	190905409	190905409	+	Splice_Site	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr4:190905409C>T	uc011clg.1	-	3	277	c.274_splice	c.e3+1	p.R92_splice		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q						'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CCGCAGCTCACGGGAAATGAA	0.657		NA											5	49					0	0	0	0
TAF7	6879	broad.mit.edu	37	5	140698816	140698816	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:140698816C>T	uc003ljg.2	-	1	1536	c.796G>A	c.(796-798)GAA>AAA	p.E266K		NM_005642	NP_005633	Q15545	TAF7_HUMAN	TATA box-binding protein-associated factor 2F	266	Potential.				negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGCTGTTCATCTGATTCA	0.448		NA											32	125					0	0	0	0
PCDH12	51294	broad.mit.edu	37	5	141325324	141325324	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:141325324C>T	uc003llx.2	-	4	4388	c.3177G>A	c.(3175-3177)GCG>GCA	p.A1059A		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	1059	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGAGTCTCGCCATCCAGG	0.667		NA											20	56					0	0	0	0
GFRAL	389400	broad.mit.edu	37	6	55223938	55223938	+	Splice_Site	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:55223938T>C	uc003pcm.1	+	6	1038	c.952_splice	c.e6+2	p.N318_splice		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor							integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATGTTTCAGTAAGTTCCCCA	0.284		NA											8	41					0	0	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128262	117128262	+	Silent	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:117128262C>G	uc003pxj.1	-	3	628	c.606G>C	c.(604-606)CTG>CTC	p.L202L	GPRC6A_uc003pxk.1_Silent_p.L202L|GPRC6A_uc003pxl.1_Silent_p.L202L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	202	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTTCTGAATCAGGTGAGCCA	0.398		NA											50	171					0	0	0	0
MYB	4602	broad.mit.edu	37	6	135510957	135510957	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:135510957G>A	uc003qfc.2	+	4	441	c.242G>A	c.(241-243)CGA>CAA	p.R81Q	MYB_uc003qfh.2_Missense_Mutation_p.R81Q|MYB_uc003qfi.2_Missense_Mutation_p.R81Q|MYB_uc010kgi.2_Missense_Mutation_p.R81Q|MYB_uc003qfq.2_Missense_Mutation_p.R81Q|MYB_uc010kgj.2_Missense_Mutation_p.R81Q|MYB_uc003qfo.2_Missense_Mutation_p.R81Q|MYB_uc003qfu.2_Missense_Mutation_p.R81Q|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_5'UTR|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.R81Q|MYB_uc003qgd.1_5'UTR	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	81	HTH myb-type 1.|H-T-H motif (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		TGCCAGCACCGATGGCAGAAA	0.398		NA	T	NFIB	adenoid cystic carcinoma								16	98					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138601971	138601971	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr7:138601971C>T	uc011kql.1	-	2	2450	c.2401G>A	c.(2401-2403)GAG>AAG	p.E801K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E751K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E801K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	801						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AAAGAAGACTCAGTTAAAATG	0.512		NA	O	BRAF	pilocytic astrocytoma								5	21					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3076900	3076900	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:3076900G>A	uc011kwk.1	-	29	4942	c.4552C>T	c.(4552-4554)CTC>TTC	p.L1518F	CSMD1_uc011kwj.1_Missense_Mutation_p.L910F|CSMD1_uc003wqe.2_Missense_Mutation_p.L674F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1518	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCCAATGAGGGGGCTGTTG	0.478		NA											3	3					0	0	0	0
ARC	23237	broad.mit.edu	37	8	143695621	143695621	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:143695621G>A	uc003ywn.1	-	1	213	c.12C>T	c.(10-12)GAC>GAT	p.D4D		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	4					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TGGTCCGGTGGTCCAGCTCCA	0.746		NA											4	10					0	0	0	0
NRBP2	340371	broad.mit.edu	37	8	144919254	144919254	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144919254G>A	uc011lkt.1	-	14	1360	c.1220C>T	c.(1219-1221)GCC>GTC	p.A407V	NRBP2_uc003yzv.2_Missense_Mutation_p.A164V|NRBP2_uc003yzz.1_Missense_Mutation_p.A25V|NRBP2_uc003yzw.2_Missense_Mutation_p.A199V|NRBP2_uc010mfl.2_Missense_Mutation_p.A199V|NRBP2_uc010mfm.2_Missense_Mutation_p.A164V|NRBP2_uc011lks.1_Missense_Mutation_p.A164V|NRBP2_uc003yzy.2_Missense_Mutation_p.A164V	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	407					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGGGGTCTTGGCCTTTTGGAC	0.607		NA											42	103					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144998170	144998170	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144998170G>A	uc003zaf.1	-	31	6508	c.6338C>T	c.(6337-6339)GCG>GTG	p.A2113V	PLEC_uc003zab.1_Missense_Mutation_p.A1976V|PLEC_uc003zac.1_Missense_Mutation_p.A1980V|PLEC_uc003zad.2_Missense_Mutation_p.A1976V|PLEC_uc003zae.1_Missense_Mutation_p.A1944V|PLEC_uc003zag.1_Missense_Mutation_p.A1954V|PLEC_uc003zah.2_Missense_Mutation_p.A1962V|PLEC_uc003zaj.2_Missense_Mutation_p.A2003V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2113	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTCCTCCGCCGCCAGCTGCCG	0.741		NA											8	7					0	0	0	0
LRSAM1	90678	broad.mit.edu	37	9	130259572	130259572	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:130259572G>A	uc004brb.1	+	24	2216	c.1871G>A	c.(1870-1872)CGG>CAG	p.R624Q	LRSAM1_uc010mxk.1_Missense_Mutation_p.R597Q|LRSAM1_uc004brc.1_Missense_Mutation_p.R624Q|LRSAM1_uc004brd.1_Missense_Mutation_p.R624Q|LRSAM1_uc004bre.1_Missense_Mutation_p.R204Q|uc004brf.1_5'Flank|LRSAM1_uc004brg.1_Missense_Mutation_p.R55Q	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	624	SAM.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GAGATCCTCCGGAGAGTCCAG	0.617		NA											7	26					0	0	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805083	133805083	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:133805083G>A	uc004bzz.2	-	2	668	c.423C>T	c.(421-423)GCC>GCT	p.A141A	FIBCD1_uc011mcc.1_Silent_p.A141A|FIBCD1_uc011mcd.1_Silent_p.A149A	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	141	Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCAGCTGGTCGGCCAGCGTGT	0.731		NA											5	9					0	0	0	0
