Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
HSPG2	3339	broad.mit.edu	37	1	22173889	22173889	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:22173889A>G	uc001bfj.2	-	62	8162	c.8122T>C	c.(8122-8124)TCC>CCC	p.S2708P	HSPG2_uc009vqd.2_Missense_Mutation_p.S2709P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2708	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ATGACGATGGAGGCCTCCAGG	0.627		NA											3	99					0	0	0	0
SYTL1	84958	broad.mit.edu	37	1	27676942	27676942	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:27676942G>A	uc001bnw.1	+	10	1138	c.971G>A	c.(970-972)CGG>CAG	p.R324Q	SYTL1_uc001bnv.1_Missense_Mutation_p.R312Q|SYTL1_uc009vsu.1_Missense_Mutation_p.R312Q|SYTL1_uc001bnx.2_3'UTR|SYTL1_uc009vsv.1_Missense_Mutation_p.R324Q	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	324	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTGAAGAAACGGAATCTGAAT	0.602		NA											42	56					0	0	0	0
PTPRU	10076	broad.mit.edu	37	1	29650167	29650167	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:29650167C>T	uc001bru.2	+	29	4119	c.4009C>T	c.(4009-4011)CGG>TGG	p.R1337W	PTPRU_uc001brv.2_Missense_Mutation_p.R1333W|PTPRU_uc001brw.2_Missense_Mutation_p.R1327W|PTPRU_uc009vtq.2_Missense_Mutation_p.R1331W|PTPRU_uc009vtr.2_Missense_Mutation_p.R1324W|PTPRU_uc001brx.2_Missense_Mutation_p.R63W	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1337	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCTGCTGGTGCGGCACTTCCA	0.642		NA											31	26					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44085815	44085815	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:44085815G>A	uc001cjr.2	+	30	5501	c.5161G>A	c.(5161-5163)GAG>AAG	p.E1721K	PTPRF_uc001cjs.2_Missense_Mutation_p.E1712K|PTPRF_uc001cju.2_Missense_Mutation_p.E1110K|PTPRF_uc009vwt.2_Missense_Mutation_p.E1281K|PTPRF_uc001cjv.2_Missense_Mutation_p.E1192K|PTPRF_uc001cjw.2_Missense_Mutation_p.E947K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1721	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.E1711Q(1)		ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGAGAGCACCGAGGACTTCTG	0.592		NA											70	60					0	0	0	0
DDX20	11218	broad.mit.edu	37	1	112303130	112303130	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:112303130G>A	uc001ebs.2	+	4	957	c.600G>A	c.(598-600)TTG>TTA	p.L200L	DDX20_uc010owf.1_5'UTR|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	200	Helicase ATP-binding.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGACTACTTGAACCCAGGCA	0.308		NA											56	64					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114215339	114215339	+	Silent	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:114215339A>G	uc001edk.2	+	18	3202	c.3021A>G	c.(3019-3021)TCA>TCG	p.S1007S	MAGI3_uc001edh.3_Silent_p.S1032S|MAGI3_uc001edi.3_Silent_p.S1007S|MAGI3_uc010owm.1_Silent_p.S1032S|MAGI3_uc001edj.2_Silent_p.S728S	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1032					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTAATTTCAGTTGTAGGCA	0.448		NA											4	261					0	0	0	0
PEX11B	8799	broad.mit.edu	37	1	145522726	145522726	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:145522726T>G	uc001eny.1	+	4	605	c.587T>G	c.(586-588)CTC>CGC	p.L196R	NBPF10_uc001emp.3_Intron|PEX11B_uc010oyu.1_Missense_Mutation_p.L182R|ITGA10_uc001enz.1_5'Flank|ITGA10_uc001eoa.2_5'Flank|ITGA10_uc010oyv.1_5'Flank|ITGA10_uc009wiw.2_5'Flank	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	196					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAAGTCCTGCTCCTGGCTCGA	0.582		NA											3	92					0	0	0	0
RPRD2	23248	broad.mit.edu	37	1	150445676	150445676	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:150445676C>T	uc009wlr.2	+	11	4453	c.4252C>T	c.(4252-4254)CGG>TGG	p.R1418W	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1392W	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1418	Pro-rich.						protein binding			ovary(1)	1						ACGGAGTCCCCGGCCAGACTT	0.582		NA											76	47					0	0	0	0
ATP1A4	480	broad.mit.edu	37	1	160141474	160141474	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:160141474T>C	uc001fve.3	+	12	2260	c.1781T>C	c.(1780-1782)CTC>CCC	p.L594P	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.L97P	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	594	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTGTGGGCCTCATATCCATG	0.488		NA											3	192					0	0	0	0
SELP	6403	broad.mit.edu	37	1	169580906	169580906	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:169580906C>T	uc001ggi.3	-	7	1036	c.971G>A	c.(970-972)TGT>TAT	p.C324Y	SELP_uc001ggh.2_Missense_Mutation_p.C159Y|SELP_uc009wvr.2_Missense_Mutation_p.C324Y	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	324	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAGGTGCTGACACTGCACAGC	0.507		NA											54	61					0	0	0	0
METTL13	51603	broad.mit.edu	37	1	171753042	171753042	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:171753042A>C	uc001ghz.2	+	2	663	c.316A>C	c.(316-318)ACG>CCG	p.T106P	METTL13_uc001gia.2_Missense_Mutation_p.T20P|METTL13_uc001gib.2_Missense_Mutation_p.T106P|METTL13_uc010pml.1_Missense_Mutation_p.T105P	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	106							methyltransferase activity|protein binding			kidney(1)	1						GATGGACATGACGCAGATGGA	0.502		NA											42	32					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186277190	186277190	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:186277190G>A	uc001gru.3	+	7	2390	c.2339G>A	c.(2338-2340)GGG>GAG	p.G780E	PRG4_uc001grt.3_Missense_Mutation_p.G739E|PRG4_uc009wyl.2_Missense_Mutation_p.G687E|PRG4_uc009wym.2_Missense_Mutation_p.G646E|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	780	51; approximate.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACCCCTAAGGGGACTGCTCCA	0.607		NA											5	231					0	0	0	0
SPATA17	128153	broad.mit.edu	37	1	217856693	217856693	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:217856693G>T	uc001hlh.1	+	5	411	c.385G>T	c.(385-387)GAT>TAT	p.D129Y	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.D129Y	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	129						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AGAGACCAATGATGCAATTAG	0.343		NA											61	60					4.09e-25	9.2e-25	1	0
VN1R5	317705	broad.mit.edu	37	1	247420369	247420369	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:247420369A>C	uc010pyu.1	+	2	996	c.996A>C	c.(994-996)CAA>CAC	p.Q332H		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	332	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			AGACTCTGCAAAtgttatggt	0.209		NA											4	37					0	0	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255111	15255111	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:15255111C>T	uc001iob.2	-	8	2483	c.2476G>A	c.(2476-2478)GGC>AGC	p.G826S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	826	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGCAGCTGGCCACCACTTCTC	0.647		NA											14	68					0	0	0	0
RBP3	5949	broad.mit.edu	37	10	48388751	48388751	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:48388751C>T	uc001jez.2	-	1	2241	c.2127G>A	c.(2125-2127)GTG>GTA	p.V709V		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	709	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTTCCTCTACCACCAGCTCGC	0.627		NA											15	51					0	0	0	0
C10orf12	26148	broad.mit.edu	37	10	98743187	98743187	+	Silent	SNP	T	T	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:98743187T>A	uc001kmv.2	+	1	2147	c.2040T>A	c.(2038-2040)GCT>GCA	p.A680A		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	680										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGGAGGAGGCTGTGAATGAGG	0.498		NA											12	58					0	0	0	0
C10orf12	26148	broad.mit.edu	37	10	98744511	98744511	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:98744511C>T	uc001kmv.2	+	1	3471	c.3364C>T	c.(3364-3366)CCT>TCT	p.P1122S		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	1122										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CACCAAAACCCCTGCTGCCAA	0.517		NA											10	62					0	0	0	0
MGEA5	10724	broad.mit.edu	37	10	103558656	103558656	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:103558656C>T	uc001ktv.2	-	9	2195	c.1752G>A	c.(1750-1752)TGG>TGA	p.W584*	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Nonsense_Mutation_p.W531*|MGEA5_uc009xws.2_Nonsense_Mutation_p.W531*|MGEA5_uc001ktw.2_Nonsense_Mutation_p.W584*|MGEA5_uc009xwt.2_Nonsense_Mutation_p.W347*	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	584	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TTGCTCGAAGCCATTGAAATT	0.443		NA											11	91					0	0	0	0
C10orf78	119392	broad.mit.edu	37	10	105882813	105882813	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:105882813C>T	uc001kxu.2	+	2	117	c.104C>T	c.(103-105)TCA>TTA	p.S35L	C10orf78_uc001kxs.2_Missense_Mutation_p.S22L|C10orf78_uc001kxt.2_5'UTR|C10orf78_uc001kxv.2_Missense_Mutation_p.S97L	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	35					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		GCGAATCCATCATCTCCCTAT	0.398		NA											13	105					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108389086	108389086	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:108389086C>T	uc001kym.2	-	19	2544	c.2536G>A	c.(2536-2538)GTC>ATC	p.V846I	SORCS1_uc001kyl.2_Missense_Mutation_p.V846I|SORCS1_uc009xxs.2_Missense_Mutation_p.V846I|SORCS1_uc001kyn.1_Missense_Mutation_p.V846I|SORCS1_uc001kyo.2_Missense_Mutation_p.V846I	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	846	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGAGATTGACGTAAGACACC	0.488		NA											8	41					0	0	0	0
FAM160B1	57700	broad.mit.edu	37	10	116593011	116593011	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:116593011C>T	uc001lcb.2	+	3	479	c.144C>T	c.(142-144)ACC>ACT	p.T48T	FAM160B1_uc001lcc.2_Silent_p.T48T	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	48										lung(1)	1						CCCCAGTGACCGATACAAATA	0.338		NA											5	45					0	0	0	0
MKI67	4288	broad.mit.edu	37	10	129913712	129913712	+	Silent	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:129913712T>C	uc001lke.2	-	7	1155	c.960A>G	c.(958-960)GGA>GGG	p.G320G	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	320					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCACGTCTCTTCCCTTCCCCT	0.547		NA											18	79					0	0	0	0
OR52D1	390066	broad.mit.edu	37	11	5509984	5509984	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:5509984C>T	uc010qzg.1	+	1	48	c.48C>T	c.(46-48)TTC>TTT	p.F16F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACACCTTCTTCTTAACAGGGA	0.488		NA											18	67					0	0	0	0
HPX	3263	broad.mit.edu	37	11	6452483	6452483	+	Silent	SNP	C	C	T	rs143855789		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:6452483C>T	uc001mdg.2	-	10	1408	c.1347G>A	c.(1345-1347)CCG>CCA	p.P449P	HPX_uc001mdf.2_Silent_p.P195P|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	449					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		TCTGGGGTTGCGGAAGGGCCT	0.542		NA											6	69					0	0	0	0
PRMT3	10196	broad.mit.edu	37	11	20409618	20409618	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:20409618G>A	uc001mqb.2	+	2	299	c.82G>A	c.(82-84)GGG>AGG	p.G28R	PRMT3_uc001mqc.2_Intron|PRMT3_uc010rdn.1_Intron	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	28							zinc ion binding				0						GTCGGACAGCGGGGACGAGGC	0.647		NA											5	39					0	0	0	0
MADD	8567	broad.mit.edu	37	11	47298327	47298327	+	Silent	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:47298327G>C	uc001ner.1	+	5	1199	c.1008G>C	c.(1006-1008)GTG>GTC	p.V336V	MADD_uc001neq.2_Silent_p.V336V|MADD_uc001nev.1_Silent_p.V336V|MADD_uc001nes.1_Silent_p.V336V|MADD_uc001net.1_Silent_p.V336V|MADD_uc009yln.1_Silent_p.V336V|MADD_uc001neu.1_Silent_p.V336V|MADD_uc001nex.2_Silent_p.V336V|MADD_uc001nez.2_Silent_p.V336V|MADD_uc001new.2_Silent_p.V336V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	336	Helical; (Potential).|DENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CCATGTCTGTGATGGCATTCG	0.483		NA											12	87					0	0	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798090	55798090	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:55798090T>G	uc010riw.1	+	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TCTTAGCAACTTATCTTTCTT	0.348		NA											6	43					0	0	0	0
SLC43A3	29015	broad.mit.edu	37	11	57175311	57175311	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:57175311T>G	uc001nkg.2	-	14	1840	c.1430A>C	c.(1429-1431)TAT>TCT	p.Y477S	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Missense_Mutation_p.Y477S|SLC43A3_uc010rjr.1_Missense_Mutation_p.Y490S|SLC43A3_uc009yme.2_Missense_Mutation_p.Y477S|SLC43A3_uc001nki.2_Missense_Mutation_p.Y477S	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	477					transmembrane transport	integral to membrane				central_nervous_system(1)	1						GCATTCCCGATATACCAGAAA	0.473		NA											3	69					0	0	0	0
MS4A2	2206	broad.mit.edu	37	11	59863040	59863040	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:59863040G>A	uc001nop.2	+	7	748	c.646G>A	c.(646-648)GAT>AAT	p.D216N		NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	216	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GGTTCCAGAGGATCGTGTTTA	0.388		NA											6	31					0	0	0	0
EXPH5	23086	broad.mit.edu	37	11	108380962	108380962	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:108380962G>A	uc001pkk.2	-	6	5383	c.5272C>T	c.(5272-5274)CTG>TTG	p.L1758L	EXPH5_uc010rvy.1_Silent_p.L1570L|EXPH5_uc010rvz.1_Silent_p.L1602L|EXPH5_uc010rwa.1_Silent_p.L1682L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1758					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GCAGGCTCCAGTGGAAAAGGA	0.512		NA											15	77					0	0	0	0
PRH2	5555	broad.mit.edu	37	12	11082884	11082884	+	Silent	SNP	C	C	T	rs1130408		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:11082884C>T	uc009zhr.2	+	2	119	c.81C>T	c.(79-81)GAC>GAT	p.D27D	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH2_uc001qzh.2_Silent_p.D27D|PRH2_uc001qzi.3_Silent_p.D27D	NM_001110213	NP_001103683	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 2	27	Inhibits hydroxyapatite formation, binds to hydroxyapatite and calcium.					extracellular space	protein binding				0						GCCAAGAAGACGTTCCCTTGG	0.388		NA											13	76					0	0	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27841969	27841969	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:27841969G>A	uc001ric.1	+	26	2913	c.2536G>A	c.(2536-2538)GTA>ATA	p.V846I	PPFIBP1_uc010sjr.1_Missense_Mutation_p.V677I|PPFIBP1_uc001rib.1_Missense_Mutation_p.V840I|PPFIBP1_uc001ria.2_Missense_Mutation_p.V815I|PPFIBP1_uc001rid.1_Missense_Mutation_p.V693I|PPFIBP1_uc001rif.1_Missense_Mutation_p.V353I	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	846	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TCGTTTTAACGTAGAAACAAT	0.338		NA											15	72					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49447796	49447796	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:49447796A>G	uc001rta.3	-	5	638	c.638T>C	c.(637-639)CTA>CCA	p.L213P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	213					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCTGGGCATAGCAGCTGCAG	0.532		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			18	69					0	0	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54110137	54110137	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:54110137C>T	uc001sef.2	-	8	1056	c.912G>A	c.(910-912)AAG>AAA	p.K304K	CALCOCO1_uc001see.2_5'Flank|CALCOCO1_uc010som.1_Intron|CALCOCO1_uc010son.1_Silent_p.K181K|CALCOCO1_uc001seh.2_Silent_p.K304K|CALCOCO1_uc009znd.2_Silent_p.K304K|CALCOCO1_uc001seg.2_Intron|CALCOCO1_uc010soo.1_Silent_p.K297K	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	304	Potential.				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CTTGCCAGCTCTTCGCCTCCT	0.562		NA											26	68					0	0	0	0
DTX3	196403	broad.mit.edu	37	12	58000719	58000719	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:58000719G>A	uc001sow.1	+	5	410	c.73G>A	c.(73-75)GTG>ATG	p.V25M	DTX3_uc001sov.1_Missense_Mutation_p.V18M|DTX3_uc001sox.1_Missense_Mutation_p.V18M|DTX3_uc001soy.1_Missense_Mutation_p.V18M	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	25					Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					GTCCAAGCCCGTGTGGGACTT	0.597		NA											99	227					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675072	81675072	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:81675072A>G	uc001szo.1	-	27	3337	c.3176T>C	c.(3175-3177)CTC>CCC	p.L1059P	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	958										ovary(3)|lung(2)|pancreas(1)	6						ATGGACACGGAGATCTTTTTT	0.343		NA											4	26					0	0	0	0
KERA	11081	broad.mit.edu	37	12	91449289	91449289	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:91449289C>T	uc001tbl.2	-	2	1389	c.770G>A	c.(769-771)AGA>AAA	p.R257K		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	257	LRR 8.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ATCAAATCCTCTTGATGGGAG	0.398		NA											19	63					0	0	0	0
NAA25	80018	broad.mit.edu	37	12	112506764	112506764	+	Nonsense_Mutation	SNP	T	T	A	rs149344901		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:112506764T>A	uc001ttm.2	-	11	1089	c.1069A>T	c.(1069-1071)AAA>TAA	p.K357*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.K329*|NAA25_uc009zwa.1_Nonsense_Mutation_p.K357*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	357						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CCAAACTTTTTAAAATACTGG	0.353		NA											13	51					0	0	0	0
MED13L	23389	broad.mit.edu	37	12	116434432	116434432	+	Missense_Mutation	SNP	T	T	C	rs35760315		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:116434432T>C	uc001tvw.2	-	16	2900	c.2845A>G	c.(2845-2847)ATG>GTG	p.M949V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	949					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGAGCAAACATGGAGGATCCC	0.438		NA											10	41					0	0	0	0
KSR2	283455	broad.mit.edu	37	12	118406030	118406030	+	Splice_Site	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:118406030C>A	uc001two.2	-	1	1	c.-54_splice	c.e1-1			NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCTGCTGCTCCTCGCTTTTC	0.522		NA											7	110					0.00198382	0.00397789	1	0
NCOR2	9612	broad.mit.edu	37	12	124862849	124862849	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:124862849C>A	uc010tba.1	-	18	2218	c.2101G>T	c.(2101-2103)GAG>TAG	p.E701*	NCOR2_uc010tay.1_Nonsense_Mutation_p.E701*|NCOR2_uc010taz.1_Nonsense_Mutation_p.E701*|NCOR2_uc010tbb.1_Nonsense_Mutation_p.E701*|NCOR2_uc010tbc.1_Nonsense_Mutation_p.E700*|NCOR2_uc001ugj.1_Nonsense_Mutation_p.E701*	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	701					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCCTCATCCTCCACCACGGGC	0.667		NA											14	53					4.38e-07	9.24e-07	1	0
ATP12A	479	broad.mit.edu	37	13	25275010	25275010	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:25275010C>T	uc001upp.2	+	13	2018	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W	ATP12A_uc010aaa.2_Missense_Mutation_p.R617W	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	611	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CGATCCCCCTCGGTCCACCGT	0.483		NA											10	48					0	0	0	0
RB1	5925	broad.mit.edu	37	13	49027134	49027134	+	Silent	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:49027134A>T	uc001vcb.2	+	18	1867	c.1701A>T	c.(1699-1701)TCA>TCT	p.S567S		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	567	Domain A.|Pocket; binds T and E1A.		S -> L (in RB).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.S567*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TATAGGATTCACCTTTATTTG	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			3	32					0	0	0	0
CLDN10	9071	broad.mit.edu	37	13	96212417	96212417	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:96212417C>G	uc001vmh.2	+	2	313	c.252C>G	c.(250-252)ATC>ATG	p.I84M	CLDN10_uc001vmg.2_Missense_Mutation_p.I82M|CLDN10_uc010tii.1_Missense_Mutation_p.I63M	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	84	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GACTTATGATCGCTGCTGTCA	0.433		NA											5	64					0	0	0	0
POTEG	404785	broad.mit.edu	37	14	19566010	19566010	+	Splice_Site	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:19566010A>T	uc001vuz.1	+	6	1108	c.1056_splice	c.e6-2	p.V352_splice	POTEG_uc001vva.1_Splice_Site|POTEG_uc010ahc.1_Splice_Site|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G											ovary(1)	1						TTTTATACATAGAATTTGCCA	0.259		NA											7	78					0	0	0	0
FOXG1	2290	broad.mit.edu	37	14	29237757	29237757	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:29237757G>A	uc001wqe.2	+	1	1471	c.1272G>A	c.(1270-1272)CCG>CCA	p.P424P		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	424					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCCGCACCCGTCAATGACTT	0.657		NA											15	47					0	0	0	0
PRKD1	5587	broad.mit.edu	37	14	30046528	30046528	+	Silent	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:30046528G>T	uc001wqh.2	-	18	2836	c.2655C>A	c.(2653-2655)ATC>ATA	p.I885I		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	885					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CACTTGGATTGATCAGGTGTG	0.517		NA											36	104					1.36e-19	3.03e-19	1	0
HEATR5A	25938	broad.mit.edu	37	14	31762629	31762629	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:31762629C>T	uc001wrf.3	-	30	5221	c.5144G>A	c.(5143-5145)CGC>CAC	p.R1715H	HEATR5A_uc010ami.2_Missense_Mutation_p.R1538H	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	2002							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AGCCTCAAGGCGGGCTTTTAG	0.378		NA											50	145					0	0	0	0
RPL10L	140801	broad.mit.edu	37	14	47120482	47120482	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:47120482C>T	uc001wwg.2	-	1	547	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	153					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CTTGGCCCTGCGCAAGGCTTC	0.517		NA											12	76					0	0	0	0
SOCS4	122809	broad.mit.edu	37	14	55509833	55509833	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:55509833A>G	uc001xbo.2	+	3	639	c.74A>G	c.(73-75)GAC>GGC	p.D25G	SOCS4_uc001xbp.2_Missense_Mutation_p.D25G	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	25					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						AGAAGTGCCGACAGAAAAGAC	0.363		NA											13	57					0	0	0	0
ZBTB1	22890	broad.mit.edu	37	14	64989074	64989074	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:64989074C>T	uc001xhh.3	+	4	1283	c.852C>T	c.(850-852)TAC>TAT	p.Y284Y	ZBTB1_uc010aqg.2_Silent_p.Y284Y|ZBTB1_uc001xhi.2_Silent_p.Y284Y	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		CGGACAAATACAGAGGAGACA	0.398		NA											11	44					0	0	0	0
EIF2S1	1965	broad.mit.edu	37	14	67843302	67843302	+	Silent	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:67843302A>C	uc001xjg.2	+	4	609	c.468A>C	c.(466-468)GCA>GCC	p.A156A		NM_004094	NP_004085	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2,	156						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		TTAAGCATGCAGTCTCGTAAG	0.428		NA											20	71					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410852	105410852	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:105410852G>A	uc010axc.1	-	7	11056	c.10936C>T	c.(10936-10938)CCG>TCG	p.P3646S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3546S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3646						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGAATGACGGCATCTTGAAT	0.592		NA											6	375					0	0	0	0
EPB42	2038	broad.mit.edu	37	15	43503700	43503700	+	Missense_Mutation	SNP	G	G	A	rs146473183		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:43503700G>A	uc001zra.3	-	4	763	c.463C>T	c.(463-465)CGC>TGC	p.R155C	EPB42_uc001zqz.3_5'Flank|EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R185C|EPB42_uc010udm.1_Missense_Mutation_p.R77C	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	155					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TACTCCATGCGCTGAGCCTCA	0.582		NA											29	56					0	0	0	0
FBN1	2200	broad.mit.edu	37	15	48760184	48760184	+	Silent	SNP	C	C	G	rs143544916		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:48760184C>G	uc001zwx.1	-	38	5026	c.4698G>C	c.(4696-4698)CTG>CTC	p.L1566L	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1566	TB 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGGCTTTACCCAGAGAACAGC	0.453		NA											17	63					0	0	0	0
SPPL2A	84888	broad.mit.edu	37	15	51031995	51031995	+	Silent	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:51031995A>G	uc001zyv.2	-	6	795	c.615T>C	c.(613-615)GAT>GAC	p.D205D		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	205						integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TCATTTCTCTATCTTCAGTTG	0.318		NA											14	54					0	0	0	0
BNC1	646	broad.mit.edu	37	15	83932492	83932492	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:83932492G>A	uc002bjt.1	-	4	1599	c.1511C>T	c.(1510-1512)ACG>ATG	p.T504M	BNC1_uc010uos.1_Missense_Mutation_p.T492M	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	504					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TATCCCAGGCGTGTTTGCTAC	0.512		NA											27	67					0	0	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84690198	84690198	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:84690198C>G	uc002bjz.3	+	26	4534	c.4310C>G	c.(4309-4311)TCT>TGT	p.S1437C	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.S1437C|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.S1437C	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1437	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCACATTGTTCTGCCACCTGT	0.517		NA											14	212					0	0	0	0
BLM	641	broad.mit.edu	37	15	91346818	91346818	+	Silent	SNP	C	C	T	rs147148171		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:91346818C>T	uc002bpr.2	+	18	3523	c.3426C>T	c.(3424-3426)GCC>GCT	p.A1142A	BLM_uc010uqh.1_Silent_p.A1142A|BLM_uc010uqi.1_Silent_p.A767A|BLM_uc010bnx.2_Intron|BLM_uc002bpt.2_Silent_p.A117A	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1142					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GACACAATGCCGAAAGACTTT	0.373		NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				21	61					0	0	0	0
SV2B	9899	broad.mit.edu	37	15	91769696	91769696	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:91769696C>T	uc002bqv.2	+	1	594	c.203C>T	c.(202-204)CCC>CTC	p.P68L	SV2B_uc002bqt.2_Missense_Mutation_p.P68L|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	68	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AAGATGGCGCCCTCCAGAATG	0.577		NA											18	44					0	0	0	0
BTBD12	84464	broad.mit.edu	37	16	3646278	3646278	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:3646278C>T	uc002cvp.2	-	8	2427	c.1800G>A	c.(1798-1800)CCG>CCA	p.P600P		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	600	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CCGAAGGCGACGGGCCCCTGG	0.731		NA						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				3	5					0	0	0	0
TMC7	79905	broad.mit.edu	37	16	19047109	19047109	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:19047109G>A	uc002dfq.2	+	7	1099	c.969G>A	c.(967-969)GCG>GCA	p.A323A	TMC7_uc010vao.1_Silent_p.A323A|TMC7_uc002dfp.2_Silent_p.A323A|TMC7_uc010vap.1_Silent_p.A213A	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	323	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3						GCAGCATGGCGGATCTGAAGC	0.542		NA											24	51					0	0	0	0
ACSM5	54988	broad.mit.edu	37	16	20439133	20439133	+	Silent	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:20439133C>A	uc002dhe.2	+	7	1092	c.945C>A	c.(943-945)ACC>ACA	p.T315T		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TCCCGATAACCACCCTCTGCT	0.478		NA											58	152					6.13e-21	1.37e-20	1	0
ZNF423	23090	broad.mit.edu	37	16	49764836	49764836	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:49764836C>T	uc002efs.2	-	4	421	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	41					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGTCTTCCAGCGCACGGCTGG	0.512		NA											39	248					0	0	0	0
HYDIN	54768	broad.mit.edu	37	16	71163606	71163606	+	Missense_Mutation	SNP	C	C	G	rs79679861		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:71163606C>G	uc002ezr.2	-	9	1292	c.1164G>C	c.(1162-1164)CAG>CAC	p.Q388H	HYDIN_uc010cfz.1_Missense_Mutation_p.Q133H|HYDIN_uc002ezv.2_Missense_Mutation_p.Q388H|HYDIN_uc010vmc.1_Missense_Mutation_p.Q405H|HYDIN_uc010vmd.1_Missense_Mutation_p.Q415H|HYDIN_uc002ezw.3_Missense_Mutation_p.Q405H	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	388										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCAGCCTCCTCTGATTCGCAA	0.448		NA											5	40					0	0	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351652	89351652	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:89351652A>C	uc002fmx.1	-	9	1759	c.1298T>G	c.(1297-1299)ATA>AGA	p.I433R	ANKRD11_uc002fmy.1_Missense_Mutation_p.I433R|ANKRD11_uc002fnc.1_Missense_Mutation_p.I433R|ANKRD11_uc002fnb.1_Missense_Mutation_p.I390R	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	433						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ACCAGGCAATATCGTATGTGC	0.428		NA											6	89					0	0	0	0
ZMYND15	84225	broad.mit.edu	37	17	4647997	4647997	+	Silent	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:4647997C>G	uc002fyt.2	+	10	1683	c.1644C>G	c.(1642-1644)GGC>GGG	p.G548G	ZMYND15_uc002fyv.2_Silent_p.G587G|ZMYND15_uc002fyu.2_Silent_p.G587G	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	548							zinc ion binding				0						AGAAAGGGGGCCGCAGGGACC	0.622		NA											7	69					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578522	7578522	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:7578522T>A	uc002gim.2	-	5	602	c.408A>T	c.(406-408)CAA>CAT	p.Q136H	TP53_uc002gig.1_Missense_Mutation_p.Q136H|TP53_uc002gih.2_Missense_Mutation_p.Q136H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q4H|TP53_uc010cng.1_Missense_Mutation_p.Q4H|TP53_uc002gii.1_Missense_Mutation_p.Q4H|TP53_uc010cnh.1_Missense_Mutation_p.Q136H|TP53_uc010cni.1_Missense_Mutation_p.Q136H|TP53_uc002gij.2_Missense_Mutation_p.Q136H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q43H|TP53_uc002gio.2_Missense_Mutation_p.Q4H|TP53_uc010vug.1_Missense_Mutation_p.Q97H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.Q136fs*13(2)|p.N131fs*27(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.L137fs*12(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTTGGCCAGTTGGCAAAACA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	44					0	0	0	0
C17orf68	80169	broad.mit.edu	37	17	8132760	8132760	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:8132760G>A	uc002gkq.3	-	19	3075	c.3016C>T	c.(3016-3018)CCC>TCC	p.P1006S	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	1006					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						TGGGGCAGGGGAATGCTAAAT	0.527		NA											10	61					0	0	0	0
SYNRG	11276	broad.mit.edu	37	17	35880712	35880712	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:35880712G>A	uc002hoa.2	-	20	3789	c.3706C>T	c.(3706-3708)CGG>TGG	p.R1236W	SYNRG_uc010wde.1_Missense_Mutation_p.R1181W|SYNRG_uc010wdf.1_Missense_Mutation_p.R1158W|SYNRG_uc002hoc.2_Missense_Mutation_p.R1157W|SYNRG_uc002hoe.2_Missense_Mutation_p.R1158W|SYNRG_uc002hod.2_Missense_Mutation_p.R1113W|SYNRG_uc010wdg.1_Missense_Mutation_p.R1030W|SYNRG_uc002hob.2_Missense_Mutation_p.R1236W	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	1236					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						ATCCCAGGCCGTAACATACAG	0.517		NA											14	52					0	0	0	0
KRT14	3861	broad.mit.edu	37	17	39740574	39740574	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:39740574C>A	uc002hxf.1	-	3	761	c.700G>T	c.(700-702)GAC>TAC	p.D234Y	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.D234Y	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	234	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				ATCTCCAGGTCAGCTCTGGCC	0.522		NA											6	172					0.00307968	0.00615936	1	0
RUNDC1	146923	broad.mit.edu	37	17	41142894	41142894	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:41142894C>T	uc002ici.1	+	5	1015	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	RUNDC1_uc010whi.1_Missense_Mutation_p.R105W	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	335											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GAAGAAAGTCCGGGAGACGGG	0.557		NA											23	77					0	0	0	0
KIAA1267	284058	broad.mit.edu	37	17	44110824	44110824	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:44110824C>T	uc002ikb.2	-	11	2754	c.2669G>A	c.(2668-2670)TGG>TAG	p.W890*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.W890*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.W890*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.W889*|KIAA1267_uc010wkb.1_Nonsense_Mutation_p.W221*|KIAA1267_uc010wkc.1_Nonsense_Mutation_p.W158*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	890						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				AACCTCCCGCCAGCTGCAAAA	0.498		NA											4	36					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58329765	58329765	+	Silent	SNP	C	C	T	rs61751977	byFrequency	TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:58329765C>T	uc002iyo.1	-	11	1399	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P	USP32_uc002iyn.1_Silent_p.P41P|USP32_uc010wov.1_Silent_p.P371P	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	371	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CTTCTTCTTCCGGAGTAGCTG	0.328		NA											6	22					0	0	0	0
HGS	9146	broad.mit.edu	37	17	79658578	79658578	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:79658578G>A	uc002kbg.2	+	8	716	c.639G>A	c.(637-639)GAG>GAA	p.E213E	HGS_uc010wus.1_Silent_p.E213E	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	213	FYVE-type.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GCGTGTGTGAGCCCTGCTACG	0.602		NA											34	91					0	0	0	0
MYOM1	8736	broad.mit.edu	37	18	3188908	3188908	+	Silent	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:3188908T>C	uc002klp.2	-	4	943	c.609A>G	c.(607-609)ACA>ACG	p.T203T	MYOM1_uc002klq.2_Silent_p.T203T	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	203	4.|6 X 6 AA tandem repeats.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCTTGGATGCTGTGGACTGCT	0.532		NA											3	95					0	0	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887074	9887074	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:9887074G>A	uc002koi.3	+	2	1047	c.598G>A	c.(598-600)GAA>AAA	p.E200K	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.E133K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	200	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|6.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GTCCTCAGAAGAAGCCATCCA	0.577		NA											5	201					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14537869	14537869	+	Silent	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:14537869G>T	uc010dln.2	-	3	1195	c.741C>A	c.(739-741)GTC>GTA	p.V247V	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	247	ANK 4.									skin(3)	3						CTTCATTGTGGACAGCATAGT	0.353		NA											40	82					4.34e-07	9.18e-07	1	0
TAF4B	6875	broad.mit.edu	37	18	23845146	23845146	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:23845146T>A	uc002kvu.3	+	2	845	c.356T>A	c.(355-357)ATT>AAT	p.I119N	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.I119N	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	119					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ACCGTTTTGATTAAAAGTAAC	0.393		NA											15	116					0	0	0	0
KLHL14	57565	broad.mit.edu	37	18	30350279	30350279	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:30350279C>T	uc002kxm.1	-	2	664	c.276G>A	c.(274-276)CCG>CCA	p.P92P		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	92	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						gctgctgtgacggctgctgct	0.522		NA											8	27					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50929242	50929242	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:50929242G>A	uc002lfe.1	+	19	3501	c.2914G>A	c.(2914-2916)GAA>AAA	p.E972K	DCC_uc010xdr.1_Missense_Mutation_p.E800K|DCC_uc010dpf.1_Missense_Mutation_p.E607K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	972	Extracellular (Potential).|Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCCTCCCTTGGAAGCCAATGG	0.532		NA											5	151					0	0	0	0
DOK6	220164	broad.mit.edu	37	18	67425109	67425109	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:67425109G>T	uc002lkl.2	+	7	1046	c.856G>T	c.(856-858)GGT>TGT	p.G286C		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	286							insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				CAGTTTGCAAGGCAAGTCACT	0.438		NA											5	46					0.00116845	0.00236123	1	0
HMHA1	23526	broad.mit.edu	37	19	1080465	1080465	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:1080465G>A	uc002lqz.1	+	15	2062	c.1831G>A	c.(1831-1833)GGG>AGG	p.G611R	HMHA1_uc010xgd.1_Missense_Mutation_p.G627R|HMHA1_uc010xge.1_Missense_Mutation_p.G479R|HMHA1_uc002lra.1_Missense_Mutation_p.G451R|HMHA1_uc002lrb.1_Missense_Mutation_p.G494R|HMHA1_uc002lrc.1_Missense_Mutation_p.G246R|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	611					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTCCAGCCGGGCGAGGACA	0.692		NA											11	57					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9085508	9085508	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:9085508G>A	uc002mkp.2	-	1	6511	c.6307C>T	c.(6307-6309)CAA>TAA	p.Q2103*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2103	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGATTTCTTTGCTTAGCAGCA	0.488		NA											24	218					0	0	0	0
RDH8	50700	broad.mit.edu	37	19	10129435	10129435	+	Silent	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:10129435G>T	uc002mmr.2	+	3	540	c.291G>T	c.(289-291)GGG>GGT	p.G97G		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	97	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GCCTGGTGGGGCCCCTGGAGG	0.507		NA											23	138					1.11e-12	2.42e-12	1	0
MAN2B1	4125	broad.mit.edu	37	19	12763060	12763060	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:12763060G>A	uc002mub.2	-	16	2029	c.1953C>T	c.(1951-1953)AAC>AAT	p.N651N	MAN2B1_uc010dyv.1_Silent_p.N650N	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	651					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						GGTCACTTTCGTTGTCACCTA	0.602		NA											22	94					0	0	0	0
ZNF101	94039	broad.mit.edu	37	19	19790618	19790618	+	Silent	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:19790618A>C	uc002nni.1	+	4	930	c.820A>C	c.(820-822)AGA>CGA	p.R274R	ZNF101_uc010ecg.1_Silent_p.R154R|ZNF101_uc002nnj.1_Silent_p.R154R	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	274	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACATGAAATCAGATCTCACGC	0.423		NA											4	35					0	0	0	0
ZNF14	7561	broad.mit.edu	37	19	19822565	19822565	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:19822565C>T	uc002nnk.1	-	4	1679	c.1525G>A	c.(1525-1527)GGT>AGT	p.G509S		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	509	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				AAGGTTTTACCGCATAGTTTA	0.393		NA											18	122					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22941431	22941431	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:22941431C>A	uc010xrh.1	-	5	1007	c.1007G>T	c.(1006-1008)TGT>TTT	p.C336F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATTCTTCACATTTGCAGGG	0.373		NA											29	65					1.75e-13	3.85e-13	1	0
WDR62	284403	broad.mit.edu	37	19	36572390	36572390	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:36572390C>T	uc002odc.2	+	10	1380	c.1289C>T	c.(1288-1290)ACT>ATT	p.T430I	WDR62_uc002odd.2_Missense_Mutation_p.T430I	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	430	WD 6.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCTTTCTGACTTGTTCTTCA	0.468		NA											15	115					0	0	0	0
SFRS16	11129	broad.mit.edu	37	19	45556084	45556084	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:45556084A>G	uc002pak.2	+	4	331	c.233A>G	c.(232-234)GAC>GGC	p.D78G	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Intron|SFRS16_uc002pam.2_Missense_Mutation_p.D78G|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	78					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACATGATTGACCGATTCGAT	0.602		NA											17	43					0	0	0	0
TMC4	147798	broad.mit.edu	37	19	54666830	54666830	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:54666830G>A	uc010erf.2	-	9	1490	c.1358C>T	c.(1357-1359)ACT>ATT	p.T453I	TMC4_uc002qdn.2_Missense_Mutation_p.T167I|TMC4_uc002qdo.2_Missense_Mutation_p.T447I	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	453	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCCCACAAGTGATCTGATT	0.582		NA											25	48					0	0	0	0
ZIM3	114026	broad.mit.edu	37	19	57648260	57648260	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:57648260C>T	uc002qnz.1	-	4	608	c.222G>A	c.(220-222)GTG>GTA	p.V74V		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACTTCCCAGCACTTCCTCTT	0.517		NA											13	81					0	0	0	0
PSD4	23550	broad.mit.edu	37	2	113949982	113949982	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:113949982T>A	uc002tjc.2	+	6	1837	c.1654T>A	c.(1654-1656)TCT>ACT	p.S552T	PSD4_uc002tjd.2_Missense_Mutation_p.S173T|PSD4_uc002tje.2_Missense_Mutation_p.S523T|PSD4_uc002tjf.2_Missense_Mutation_p.S173T	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	552	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						ACCGATGAACTCTTCTTGGCT	0.547		NA											84	146					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179472661	179472661	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:179472661C>T	uc010zfg.1	-	225	45373	c.45149G>A	c.(45148-45150)CGC>CAC	p.R15050H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8745H|TTN_uc010zfi.1_Missense_Mutation_p.R8678H|TTN_uc010zfj.1_Missense_Mutation_p.R8553H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15977							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGTGCAGCGTGACCATTC	0.478		NA											34	103					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202131228	202131228	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:202131228C>G	uc002uxr.1	+	3	228	c.19C>G	c.(19-21)CTT>GTT	p.L7V	CASP8_uc010ftc.1_Missense_Mutation_p.L7V|CASP8_uc002uxo.1_Missense_Mutation_p.L7V|CASP8_uc002uxp.1_Missense_Mutation_p.L7V|CASP8_uc002uxq.1_Missense_Mutation_p.L7V|CASP8_uc002uxs.1_Missense_Mutation_p.L7V|CASP8_uc002uxt.1_Missense_Mutation_p.L66V|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.L7V|CASP8_uc002uxw.1_Missense_Mutation_p.L7V|CASP8_uc002uxy.1_Missense_Mutation_p.L7V|CASP8_uc002uxx.1_Missense_Mutation_p.L7V|CASP8_uc010ftf.2_Missense_Mutation_p.L7V	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	7	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CAGCAGAAATCTTTATGATAT	0.408		NA								HNSCC(4;0.00038)			16	43					0	0	0	0
ALS2	57679	broad.mit.edu	37	2	202625656	202625656	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:202625656T>A	uc002uyo.2	-	4	1417	c.1061A>T	c.(1060-1062)GAT>GTT	p.D354V	ALS2_uc002uyp.3_Missense_Mutation_p.D354V|ALS2_uc002uyq.2_Missense_Mutation_p.D354V|ALS2_uc002uyr.2_Missense_Mutation_p.D354V	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	354					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TACTGAATGATCTGACAGTTT	0.413		NA											17	74					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212488657	212488657	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:212488657G>A	uc002veg.1	-	18	2290	c.2192C>T	c.(2191-2193)ACG>ATG	p.T731M	ERBB4_uc002veh.1_Missense_Mutation_p.T731M|ERBB4_uc010zji.1_Missense_Mutation_p.T721M|ERBB4_uc010zjj.1_Missense_Mutation_p.T721M|ERBB4_uc010fut.1_Missense_Mutation_p.T731M	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	731	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTATAAACCGTTCCAAAAGC	0.363		NA								TSP Lung(8;0.080)			11	49					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212568852	212568852	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:212568852G>A	uc002veg.1	-	11	1364	c.1266C>T	c.(1264-1266)ACC>ACT	p.T422T	ERBB4_uc002veh.1_Silent_p.T422T|ERBB4_uc010zji.1_Silent_p.T422T|ERBB4_uc010zjj.1_Silent_p.T422T|ERBB4_uc010fut.1_Silent_p.T422T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	422	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTCCACCAATGGTCACCAGGT	0.393		NA								TSP Lung(8;0.080)			21	80					0	0	0	0
ASB18	401036	broad.mit.edu	37	2	237172797	237172797	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:237172797G>A	uc010znh.1	-	1	192	c.192C>T	c.(190-192)ACC>ACT	p.T64T		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	64					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		GCAGCATGCCGGTGGGCAGCT	0.527		NA											4	33					0	0	0	0
LBP	3929	broad.mit.edu	37	20	36992665	36992665	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr20:36992665A>T	uc002xic.1	+	7	724	c.689A>T	c.(688-690)TAT>TTT	p.Y230F		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	230					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GACATTGATTATAGCTTAGTG	0.557		NA											16	40					0	0	0	0
C20orf111	51526	broad.mit.edu	37	20	42825851	42825851	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr20:42825851C>T	uc002xlk.2	-	4	857	c.720G>A	c.(718-720)TCG>TCA	p.S240S		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	240											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TGGCGTGCAGCGACTGAGAGT	0.532		NA											8	102					0	0	0	0
FOXRED2	80020	broad.mit.edu	37	22	36900343	36900343	+	Missense_Mutation	SNP	G	G	A	rs142793535		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:36900343G>A	uc003apn.3	-	3	959	c.851C>T	c.(850-852)ACG>ATG	p.T284M	FOXRED2_uc003apo.3_Missense_Mutation_p.T284M|FOXRED2_uc003app.3_Missense_Mutation_p.T284M	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	284					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GGCCAGATCCGTCAGGTCAGA	0.562		NA											24	46					0	0	0	0
CBX7	23492	broad.mit.edu	37	22	39529912	39529912	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:39529912C>A	uc003axb.2	-	6	829	c.740G>T	c.(739-741)CGC>CTC	p.R247L	CBX7_uc003axc.2_Missense_Mutation_p.R154L	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	247					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					CTTCCCACTGCGGTCTCGGAA	0.577		NA											12	74					9.31e-06	1.94e-05	1	0
MKL1	57591	broad.mit.edu	37	22	40815260	40815260	+	Silent	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:40815260A>G	uc003ayv.1	-	9	1389	c.1182T>C	c.(1180-1182)CCT>CCC	p.P394P	MKL1_uc003ayw.1_Silent_p.P394P|MKL1_uc010gye.1_Silent_p.P394P|MKL1_uc010gyf.1_Silent_p.P344P	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	394					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGGTGGCGGCAGGGGCCTTGG	0.657		NA	T	RBM15	acute megakaryocytic leukemia								6	16					0	0	0	0
IL17REL	400935	broad.mit.edu	37	22	50439548	50439548	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:50439548C>T	uc003bje.1	-	4	304	c.72G>A	c.(70-72)GCG>GCA	p.A24A		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	24										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCAGGAGCATCGCGCAGCCGT	0.662		NA											6	11					0	0	0	0
LMF2	91289	broad.mit.edu	37	22	50943500	50943500	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:50943500A>G	uc003blp.2	-	9	1271	c.1240T>C	c.(1240-1242)TTC>CTC	p.F414L	LMF2_uc010hba.2_Missense_Mutation_p.F236L|LMF2_uc003blo.2_Missense_Mutation_p.F389L	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	414	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTAATCAGGAACAAGGCCACG	0.647		NA											12	41					0	0	0	0
SETMAR	6419	broad.mit.edu	37	3	4355272	4355272	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:4355272C>G	uc011asp.1	+	2	914	c.847C>G	c.(847-849)CTA>GTA	p.L283V	SUMF1_uc003bps.1_Intron|SETMAR_uc003bpw.3_Missense_Mutation_p.L270V|SETMAR_uc003bpy.3_Intron|SETMAR_uc011asq.1_Intron|SETMAR_uc011asr.1_Intron|SETMAR_uc010hbx.2_Missense_Mutation_p.L78V	NM_006515	NP_006506	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion	270	Post-SET.|Histone-lysine N-methyltransferase.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			ovary(1)	1		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		TCATGGGAAACTAAGGAAACC	0.403		NA						Chromatin_Structure|Direct_reversal_of_damage					10	34					0	0	0	0
SLMAP	7871	broad.mit.edu	37	3	57898145	57898145	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:57898145C>T	uc003dje.1	+	18	1891	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	SLMAP_uc003djd.1_Silent_p.L545L|SLMAP_uc003djf.1_Silent_p.L524L|SLMAP_uc003djg.1_Silent_p.L156L|SLMAP_uc011bez.1_Silent_p.L30L|SLMAP_uc011bfa.1_Silent_p.L96L|SLMAP_uc003djh.2_Silent_p.L55L|SLMAP_uc003dji.1_Silent_p.L96L|SLMAP_uc011bfb.1_Silent_p.L96L|SLMAP_uc011bfc.1_Silent_p.L55L	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	562	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		CTGAGAATCTCCGGGAGGAGA	0.413		NA											11	56					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868899	97868899	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:97868899A>C	uc003dsg.1	+	1	670	c.670A>C	c.(670-672)ACA>CCA	p.T224P		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTCCTCTATACAATCTTGAA	0.358		NA											3	38					0	0	0	0
OR5H6	79295	broad.mit.edu	37	3	97983841	97983841	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:97983841T>C	uc003dsi.1	+	1	713	c.713T>C	c.(712-714)CTC>CCC	p.L238P		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						ACAATTATCCTCTTTACAATC	0.353		NA											4	35					0	0	0	0
HHLA2	11148	broad.mit.edu	37	3	108072558	108072558	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:108072558G>A	uc003dwy.3	+	4	516	c.349G>A	c.(349-351)GGA>AGA	p.G117R	HHLA2_uc011bhl.1_Missense_Mutation_p.G53R|HHLA2_uc010hpu.2_Missense_Mutation_p.G117R|HHLA2_uc003dwz.2_Missense_Mutation_p.G117R	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	117	Ig-like V-type 1.					integral to membrane				ovary(1)	1						TCTGGACGAAGGAATTTACAC	0.403		NA											15	34					0	0	0	0
IGSF10	285313	broad.mit.edu	37	3	151161398	151161398	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:151161398C>A	uc011bod.1	-	5	5337	c.5337G>T	c.(5335-5337)TGG>TGT	p.W1779C	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1779	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGCAAGAATCCAGGTAACTG	0.498		NA											16	93					9.17e-09	1.97e-08	1	0
MSX1	4487	broad.mit.edu	37	4	4864759	4864759	+	Silent	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:4864759G>T	uc003gif.2	+	2	1036	c.801G>T	c.(799-801)GCG>GCT	p.A267A		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	261	Poly-Ala.				apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGGCCGCGGCGGGTGCCTCGC	0.706		NA											6	18					5.94e-07	1.25e-06	1	0
AIMP1	9255	broad.mit.edu	37	4	107252981	107252981	+	Missense_Mutation	SNP	G	G	A	rs148281523		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:107252981G>A	uc011cfg.1	+	5	596	c.544G>A	c.(544-546)GGA>AGA	p.G182R	AIMP1_uc003hyg.2_Missense_Mutation_p.G182R|AIMP1_uc003hyh.2_Missense_Mutation_p.G206R	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	182	tRNA-binding.|Interaction with HSP90B1 (By similarity).|Required for endothelial cell migration.				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						AGTAGATGTCGGAGAAATAGC	0.428		NA											27	189					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126241670	126241670	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:126241670C>T	uc003ifj.3	+	1	4104	c.4104C>T	c.(4102-4104)AAC>AAT	p.N1368N		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1368	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTAGCCCAAACACTGGGAGTA	0.378		NA											21	72					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247226	153247226	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:153247226A>G	uc003ims.2	-	10	1725	c.1576T>C	c.(1576-1578)TGG>CGG	p.W526R	FBXW7_uc011cii.1_Missense_Mutation_p.W526R|FBXW7_uc003imt.2_Missense_Mutation_p.W526R|FBXW7_uc011cih.1_Missense_Mutation_p.W350R|FBXW7_uc003imq.2_Missense_Mutation_p.W446R|FBXW7_uc003imr.2_Missense_Mutation_p.W408R	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	526	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.W526R(2)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TCTGGATCCCACACCTTTACC	0.428		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								16	89					0	0	0	0
ACCN5	51802	broad.mit.edu	37	4	156752996	156752996	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:156752996A>T	uc003ipe.1	-	9	1354	c.1307T>A	c.(1306-1308)GTG>GAG	p.V436E		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	436	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		AGACACACTCACCGCCTTTTG	0.249		NA											17	73					0	0	0	0
WDR17	116966	broad.mit.edu	37	4	177081214	177081214	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:177081214G>A	uc003iuj.2	+	20	2823	c.2667G>A	c.(2665-2667)GTG>GTA	p.V889V	WDR17_uc003iuk.2_Silent_p.V865V|WDR17_uc003ium.3_Silent_p.V865V|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Silent_p.V108V	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	889										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTGGTGATGTGAAAAAGCTAG	0.378		NA											8	32					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187628208	187628208	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:187628208G>C	uc003izf.2	-	2	2962	c.2774C>G	c.(2773-2775)CCT>CGT	p.P925R	FAT1_uc010iso.1_Missense_Mutation_p.P925R	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	925	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AATAAATGTAGGTGGGTTGTC	0.458		NA								HNSCC(5;0.00058)			38	249					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23522511	23522511	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:23522511C>A	uc003jgo.2	+	7	789	c.607C>A	c.(607-609)CTC>ATC	p.L203I		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	203					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGATGATTACCTCTGTAAGTG	0.438		NA								HNSCC(3;0.000094)			32	110					9.66e-10	2.1e-09	1	0
OTP	23440	broad.mit.edu	37	5	76932942	76932942	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:76932942G>A	uc003kfg.2	-	2	299	c.151C>T	c.(151-153)CCA>TCA	p.P51S		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		CCCTCCACTGGGTCAGAGTTG	0.716		NA											8	9					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:140237249G>C	uc003lhx.2	+	1	1616	c.1616G>C	c.(1615-1617)GGG>GCG	p.G539A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.G539A	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	539	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687		NA											7	107					0	0	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558802	140558802	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:140558802C>A	uc011dai.1	+	1	1373	c.1187C>A	c.(1186-1188)TCT>TAT	p.S396Y	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	396	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTGAAATCTTCTGTGGGG	0.453		NA											34	447					2.82e-10	6.16e-10	1	0
ITK	3702	broad.mit.edu	37	5	156668657	156668657	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:156668657C>T	uc003lwo.1	+	11	1069	c.987C>T	c.(985-987)GGC>GGT	p.G329G		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	329	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCAACCCAGGCCTGGTGACTC	0.448		NA	T	SYK	peripheral T-cell lymphoma								9	24					0	0	0	0
GFPT2	9945	broad.mit.edu	37	5	179740899	179740899	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:179740899C>T	uc003mlw.1	-	14	1437	c.1339G>A	c.(1339-1341)GTC>ATC	p.V447I		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	447	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GTGTTGGTGACGCCCACGGTG	0.706		NA											4	14					0	0	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900802	2900802	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:2900802A>G	uc003mug.2	-	2	165	c.44T>C	c.(43-45)CTT>CCT	p.L15P	uc003mue.2_RNA|SERPINB9_uc003muh.2_Missense_Mutation_p.L15P	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	15					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TATCTTTAAAAGGCGTATGGC	0.473		NA											3	162					0	0	0	0
LRFN2	57497	broad.mit.edu	37	6	40399668	40399668	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:40399668G>A	uc003oph.1	-	2	1650	c.1185C>T	c.(1183-1185)CGC>CGT	p.R395R		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	395	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTCTGAGAGGCGGGACTTGG	0.667		NA											14	43					0	0	0	0
PHF3	23469	broad.mit.edu	37	6	64422707	64422707	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:64422707G>A	uc003pep.1	+	15	5249	c.5223G>A	c.(5221-5223)GAG>GAA	p.E1741E	PHF3_uc003pen.2_Silent_p.E1653E|PHF3_uc011dxs.1_Silent_p.E1010E	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1741					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCTTACAGGAGGATATTTTAA	0.388		NA											10	41					0	0	0	0
MED23	9439	broad.mit.edu	37	6	131917269	131917269	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:131917269G>A	uc003qcs.1	-	22	2987	c.2813C>T	c.(2812-2814)GCG>GTG	p.A938V	MED23_uc003qcq.2_Missense_Mutation_p.A944V|MED23_uc003qcr.1_5'Flank|MED23_uc011eca.1_Missense_Mutation_p.A579V	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	938					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CACCTGTTCCGCGAGGCCCTC	0.383		NA											25	70					0	0	0	0
AHR	196	broad.mit.edu	37	7	17349613	17349613	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:17349613G>C	uc011jxz.1	+	2	732	c.119G>C	c.(118-120)AGA>ACA	p.R40T	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	40	Basic motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAGCGGCATAGAGACCGACTT	0.383		NA											8	38					0	0	0	0
MACC1	346389	broad.mit.edu	37	7	20199733	20199733	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:20199733A>G	uc003sus.3	-	5	560	c.251T>C	c.(250-252)CTA>CCA	p.L84P	MACC1_uc010kug.2_Missense_Mutation_p.L84P	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	84					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GTTATTTCTTAGTTGAGTTAT	0.348		NA											16	37					0	0	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378780	31378780	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:31378780C>G	uc003tch.2	-	2	456	c.103G>C	c.(103-105)GAA>CAA	p.E35Q		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	35					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GAAAAGCTTTCTGGCTTCTTA	0.333		NA											37	121					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48390266	48390266	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:48390266C>T	uc003toq.2	+	30	10256	c.10231C>T	c.(10231-10233)CAT>TAT	p.H3411Y	ABCA13_uc010kys.1_Missense_Mutation_p.H485Y|ABCA13_uc003tos.1_Missense_Mutation_p.H237Y	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3411					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GATGTTTAACCATGCAGGCGC	0.512		NA											63	103					0	0	0	0
ZPBP	11055	broad.mit.edu	37	7	50121443	50121443	+	Silent	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:50121443C>G	uc003tou.2	-	3	331	c.261G>C	c.(259-261)ACG>ACC	p.T87T	ZPBP_uc011kci.1_Silent_p.T13T|ZPBP_uc010kyw.2_Silent_p.T87T	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	87					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GCAGTTGTTGCGTTACACATA	0.343		NA											23	39					0	0	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432010	117432010	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:117432010C>T	uc003vjf.2	-	4	1332	c.1240G>A	c.(1240-1242)GGC>AGC	p.G414S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	414	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGAGCTATGCCTGGTGTTTGA	0.527		NA											4	142					0	0	0	0
FAM115C	285966	broad.mit.edu	37	7	143417084	143417084	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:143417084G>T	uc003wdf.2	+	3	1015	c.932G>T	c.(931-933)TGT>TTT	p.C311F	FAM115C_uc003wdg.2_Missense_Mutation_p.C30F|FAM115C_uc011ktk.1_Missense_Mutation_p.C311F|FAM115C_uc003wdh.2_Missense_Mutation_p.C311F|FAM115C_uc011ktm.1_Missense_Mutation_p.C311F|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Missense_Mutation_p.C147F|FAM115C_uc003wdi.1_Missense_Mutation_p.C30F	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	311											0						AAAGATCTGTGTCCTCTCCTA	0.562		NA											6	19					1.59e-06	3.33e-06	1	0
SNTG1	54212	broad.mit.edu	37	8	51571204	51571204	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:51571204T>C	uc010lxy.1	+	16	1390	c.1019T>C	c.(1018-1020)ATT>ACT	p.I340T	SNTG1_uc003xqs.1_Missense_Mutation_p.I340T|SNTG1_uc010lxz.1_Missense_Mutation_p.I340T|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	340	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTTTATGAGATTATGTGCAAG	0.358		NA											26	30					0	0	0	0
SULF1	23213	broad.mit.edu	37	8	70476367	70476367	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:70476367C>T	uc010lza.1	+	5	874	c.157C>T	c.(157-159)CAA>TAA	p.Q53*	SULF1_uc003xyd.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xye.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xyf.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xyg.2_Nonsense_Mutation_p.Q53*	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	53					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACCGATGATCAAGATGTGGA	0.468		NA											26	108					0	0	0	0
TRAM1	23471	broad.mit.edu	37	8	71520380	71520380	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:71520380C>T	uc003xyo.1	-	1	225	c.55G>A	c.(55-57)GTC>ATC	p.V19I	TRAM1_uc011lfc.1_Intron	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	19	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			TTCTGCAGGACGAATTCGTGG	0.662		NA											24	103					0	0	0	0
ZBTB10	65986	broad.mit.edu	37	8	81400004	81400004	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:81400004A>G	uc003ybx.3	+	1	1557	c.959A>G	c.(958-960)GAA>GGA	p.E320G	ZBTB10_uc003ybv.3_Intron|ZBTB10_uc003ybw.3_Missense_Mutation_p.E320G|ZBTB10_uc010lzt.2_Missense_Mutation_p.E320G	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	320					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			AAACTCCACGAAGCCAACGCC	0.537		NA											6	102					0	0	0	0
NECAB1	64168	broad.mit.edu	37	8	91929759	91929759	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:91929759A>T	uc011lgg.1	+	6	591	c.397A>T	c.(397-399)AGA>TGA	p.R133*		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	133					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATTCGTAACTAGATTTTTATT	0.403		NA											14	28					0	0	0	0
NECAB1	64168	broad.mit.edu	37	8	91929771	91929771	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:91929771A>T	uc011lgg.1	+	6	603	c.409A>T	c.(409-411)AAG>TAG	p.K137*		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	137	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATTTTTATTGAAGGAAACCCT	0.393		NA											16	30					0	0	0	0
INTS8	55656	broad.mit.edu	37	8	95862216	95862216	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:95862216G>C	uc003yhb.2	+	12	1530	c.1404G>C	c.(1402-1404)TTG>TTC	p.L468F	INTS8_uc003yha.1_Missense_Mutation_p.L468F|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.L295F	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	468					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TCATTACATTGTTGAAAGATG	0.353		NA											8	76					0	0	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999224	143999224	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:143999224C>T	uc003yxk.1	-	1	36	c.33G>A	c.(31-33)GTG>GTA	p.V11V		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	11					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	AGGGCGCTGCCACGCACACCT	0.617		NA							Familial_Hyperaldosteronism_type_I				41	180					0	0	0	0
FAM83H	286077	broad.mit.edu	37	8	144811234	144811234	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:144811234G>T	uc003yzk.2	-	4	709	c.640C>A	c.(640-642)CCC>ACC	p.P214T	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	214					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TAGTAGGTGGGGCCCGCCACA	0.627		NA											31	112					3.9e-15	8.6e-15	1	0
PLEC	5339	broad.mit.edu	37	8	145012832	145012832	+	Silent	SNP	G	G	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:145012832G>T	uc003zaf.1	-	2	722	c.552C>A	c.(550-552)ACC>ACA	p.T184T	PLEC_uc003zab.1_Silent_p.T47T|PLEC_uc003zac.1_Silent_p.T51T|PLEC_uc003zad.2_Silent_p.T47T|PLEC_uc003zae.1_Silent_p.T15T|PLEC_uc003zag.1_Silent_p.T25T|PLEC_uc003zah.2_Silent_p.T33T|PLEC_uc003zaj.2_Silent_p.T74T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	184	CH 1.|Globular 1.|Actin-binding.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACTTGGTGAAGGTTTTCTTCT	0.637		NA											17	85					6.94e-10	1.51e-09	1	0
TPD52L3	89882	broad.mit.edu	37	9	6328941	6328941	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:6328941G>A	uc003zjw.2	+	1	567	c.346G>A	c.(346-348)GCC>ACC	p.A116T	TPD52L3_uc003zjv.2_Missense_Mutation_p.A116T|TPD52L3_uc003zjx.1_Missense_Mutation_p.A116T	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	116							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		GAAGAAGTCGGCCACATTCAG	0.517		NA											12	74					0	0	0	0
TTC39B	158219	broad.mit.edu	37	9	15199906	15199906	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:15199906G>A	uc003zlr.1	-	8	700	c.579C>T	c.(577-579)AAC>AAT	p.N193N	TTC39B_uc003zlq.1_Silent_p.N162N|TTC39B_uc011lmp.1_Silent_p.N94N|TTC39B_uc010mie.1_Silent_p.N191N|TTC39B_uc011lmq.1_Silent_p.N193N|TTC39B_uc011lmr.1_Silent_p.N124N|TTC39B_uc010mif.1_Silent_p.N193N|TTC39B_uc003zls.1_Silent_p.N94N|TTC39B_uc010mig.1_Silent_p.N162N|TTC39B_uc011lms.1_Intron	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	193							binding			ovary(1)	1						CTTTGATGAAGTTGATCATAT	0.274		NA											4	22					0	0	0	0
ACO1	48	broad.mit.edu	37	9	32407405	32407405	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:32407405C>T	uc003zqw.3	+	3	399	c.244C>T	c.(244-246)CGT>TGT	p.R82C	ACO1_uc010mjh.1_5'UTR|ACO1_uc003zqx.3_Missense_Mutation_p.R82C|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	82					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TAAGCCTGCTCGTGTCATCCT	0.388		NA											9	44					0	0	0	0
CCDC107	203260	broad.mit.edu	37	9	35658694	35658694	+	Silent	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:35658694C>G	uc011lox.1	+	2	294	c.228C>G	c.(226-228)GTC>GTG	p.V76V	RMRP_uc003zxh.1_5'Flank|CCDC107_uc010mkx.1_Silent_p.V76V|CCDC107_uc011loy.1_Silent_p.V76V|CCDC107_uc003zxj.2_Silent_p.V76V|CCDC107_uc003zxk.2_Silent_p.V76V	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	76	Helical; (Potential).					integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCGCGGCCGTCGCGGCTTTTG	0.731		NA											11	32					0	0	0	0
PGM5	5239	broad.mit.edu	37	9	71098810	71098810	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:71098810C>T	uc004agr.2	+	9	1554	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	442					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						GATCCCAAGACGACATATTAT	0.512		NA											15	51					0	0	0	0
SHC3	53358	broad.mit.edu	37	9	91657049	91657049	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:91657049T>C	uc004aqg.2	-	10	1559	c.1252A>G	c.(1252-1254)ACG>GCG	p.T418A		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	418	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						GCTTCTCCCGTGGGGGCCACG	0.572		NA											35	102					0	0	0	0
SPTAN1	6709	broad.mit.edu	37	9	131367378	131367378	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:131367378G>C	uc004bvl.3	+	30	3898	c.3785G>C	c.(3784-3786)GGA>GCA	p.G1262A	SPTAN1_uc011mbh.1_Missense_Mutation_p.G1274A|SPTAN1_uc004bvm.3_Missense_Mutation_p.G1262A|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1242A	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1262	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GACAATTATGGACATGATCTC	0.488		NA											5	42					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139396213	139396213	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:139396213A>T	uc004chz.2	-	30	5625	c.5625T>A	c.(5623-5625)AAT>AAA	p.N1875K		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1875	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCCGCGGACATTGACGTCCA	0.662		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	29					0	0	0	0
FANCB	2187	broad.mit.edu	37	X	14861944	14861944	+	Silent	SNP	A	A	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:14861944A>C	uc004cwg.1	-	10	2593	c.2325T>G	c.(2323-2325)TCT>TCG	p.S775S	FANCB_uc004cwh.1_Silent_p.S775S	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	775					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TAGCTATGGCAGAAGAAAGAG	0.383		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				14	71					0	0	0	0
LANCL3	347404	broad.mit.edu	37	X	37431412	37431412	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:37431412A>T	uc011mkd.1	+	1	591	c.289A>T	c.(289-291)AAG>TAG	p.K97*	LANCL3_uc004ddp.1_Nonsense_Mutation_p.K97*	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	97							catalytic activity				0						GCGCTCGGCTAAGCGCCTCAT	0.716		NA											4	13					0	0	0	0
LANCL3	347404	broad.mit.edu	37	X	37431414	37431414	+	Silent	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:37431414G>A	uc011mkd.1	+	1	593	c.291G>A	c.(289-291)AAG>AAA	p.K97K	LANCL3_uc004ddp.1_Silent_p.K97K	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	97							catalytic activity				0						GCTCGGCTAAGCGCCTCATCG	0.716		NA											4	13					0	0	0	0
SUV39H1	6839	broad.mit.edu	37	X	48564736	48564736	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:48564736C>A	uc004dkn.2	+	4	954	c.909C>A	c.(907-909)TAC>TAA	p.Y303*	SUV39H1_uc011mmf.1_Nonsense_Mutation_p.Y314*|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	303	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						ACCTGGACTACGTGGAGGACG	0.612		NA											13	69					6.32e-08	1.34e-07	1	0
FOXR2	139628	broad.mit.edu	37	X	55650595	55650595	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:55650595G>A	uc004duo.2	+	1	763	c.451G>A	c.(451-453)GAC>AAC	p.D151N		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	151					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						TTCCCCCAGTGACTTTGAGCT	0.502		NA											9	54					0	0	0	0
VSIG4	11326	broad.mit.edu	37	X	65253341	65253341	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:65253341C>A	uc004dwh.2	-	2	514	c.387G>T	c.(385-387)AAG>AAT	p.K129N	VSIG4_uc004dwi.2_Missense_Mutation_p.K129N|VSIG4_uc010nkq.1_Missense_Mutation_p.K129N|VSIG4_uc004dwj.2_Missense_Mutation_p.K129N|VSIG4_uc011moy.1_Missense_Mutation_p.K129N|VSIG4_uc004dwk.2_Missense_Mutation_p.K129N|VSIG4_uc004dwl.2_Missense_Mutation_p.K25N	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	129	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GCTCAGTAATCTTATCTCTCA	0.473		NA											28	121					1.16e-09	2.51e-09	1	0
ZMYM3	9203	broad.mit.edu	37	X	70461117	70461117	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:70461117G>A	uc004dzh.1	-	24	3967	c.3880C>T	c.(3880-3882)CGC>TGC	p.R1294C	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.R1294C|ZMYM3_uc004dzj.1_Missense_Mutation_p.R1282C	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1294					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					ACAGGGCAGCGGAGGGGATTC	0.507		NA											5	39					0	0	0	0
ERCC6L	54821	broad.mit.edu	37	X	71425660	71425660	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:71425660G>C	uc004eaq.1	-	2	3054	c.2957C>G	c.(2956-2958)CCT>CGT	p.P986R	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.P863R	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	986					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TCTGGAATTAGGTGCAGAGCC	0.393		NA											30	59					0	0	0	0
ARMCX3	51566	broad.mit.edu	37	X	100879979	100879979	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:100879979G>A	uc004ehz.1	+	5	543	c.10G>A	c.(10-12)GCC>ACC	p.A4T	ARMCX3_uc004eia.1_Missense_Mutation_p.A4T|ARMCX3_uc004eib.1_Missense_Mutation_p.A4T|ARMCX3_uc004eic.1_Missense_Mutation_p.A4T	NM_016607	NP_057691	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	4						integral to membrane	binding			ovary(1)|lung(1)	2						CATGGGCTACGCCAGGAAAGT	0.557		NA											15	80					0	0	0	0
NXF5	55998	broad.mit.edu	37	X	101095787	101095787	+	Silent	SNP	G	G	C			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:101095787G>C	uc011mrk.1	-	9	921	c.561C>G	c.(559-561)GTC>GTG	p.V187V	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	187	LRR 2.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAGGGTCTTGACTTTGGGAG	0.478		NA											5	44					0	0	0	0
NXF3	56000	broad.mit.edu	37	X	102337969	102337969	+	Silent	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:102337969C>T	uc004eju.2	-	7	725	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	NXF3_uc010noi.1_Silent_p.Q68Q|NXF3_uc011mrw.1_Silent_p.Q218Q|NXF3_uc011mrx.1_Silent_p.Q129Q	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	218						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CAAGAGCTTCCTGGGAGACAT	0.498		NA											33	308					0	0	0	0
HTR2C	3358	broad.mit.edu	37	X	114141460	114141460	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:114141460C>T	uc004epu.1	+	6	1587	c.859C>T	c.(859-861)CGC>TGC	p.R287C	HTR2C_uc010nqc.1_Missense_Mutation_p.R287C|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	287	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CCAGAACGCACGCCGAAGAAA	0.493		NA											20	141					0	0	0	0
PGRMC1	10857	broad.mit.edu	37	X	118370576	118370576	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:118370576G>A	uc004erb.2	+	1	366	c.250G>A	c.(250-252)GTC>ATC	p.V84I	PGRMC1_uc011mts.1_Missense_Mutation_p.V84I	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	84	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CTTCGACGGCGTCCAGGACCC	0.721		NA											4	30					0	0	0	0
ODZ1	10178	broad.mit.edu	37	X	123518065	123518065	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:123518065C>G	uc004euj.2	-	29	6759	c.6695G>C	c.(6694-6696)GGC>GCC	p.G2232A	ODZ1_uc011muj.1_Missense_Mutation_p.G2238A|ODZ1_uc010nqy.2_Missense_Mutation_p.G2239A	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2232	YD 20.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGCAGCAGGCCATTAGAATT	0.463		NA											9	82					0	0	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092703	151092703	+	Silent	SNP	C	C	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:151092703C>G	uc004fez.2	+	3	723	c.567C>G	c.(565-567)GGC>GGG	p.G189G	MAGEA4_uc004ffa.2_Silent_p.G189G|MAGEA4_uc004ffb.2_Silent_p.G189G|MAGEA4_uc004ffc.2_Silent_p.G189G|MAGEA4_uc004ffd.2_Silent_p.G189G	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	189	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATGATGGCCTGCTGGGTA	0.537		NA											15	161					0	0	0	0
MPP1	4354	broad.mit.edu	37	X	154013398	154013398	+	Missense_Mutation	SNP	C	C	T	rs146674414		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:154013398C>T	uc004fmp.1	-	7	827	c.712G>A	c.(712-714)GAA>AAA	p.E238K	MPP1_uc010nvg.1_Missense_Mutation_p.E218K|MPP1_uc011mzv.1_Missense_Mutation_p.E208K|MPP1_uc004fmq.1_Missense_Mutation_p.E192K|MPP1_uc011mzw.1_Missense_Mutation_p.E221K|MPP1_uc010nvh.1_Missense_Mutation_p.E112K	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	238					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCGGGGCTTCGCTAGGAGCT	0.552		NA											4	25					0	0	0	0
F8	2157	broad.mit.edu	37	X	154159320	154159320	+	Silent	SNP	T	T	G			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:154159320T>G	uc004fmt.2	-	14	2916	c.2745A>C	c.(2743-2745)GCA>GCC	p.A915A		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	915	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATCAGTACCTGCTGCCAAAT	0.378		NA											5	82					0	0	0	0
ITGB3	3690	broad.mit.edu	37	17	45361893	45361893	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:45361893delC	uc002ilj.2	+	4	466	c.446delC	c.(445-447)TCCfs	p.S149fs	ITGB3_uc002ili.1_Frame_Shift_Del_p.S149fs|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	149	VWFA.|Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CTGTCTTACTCCATGAAGGAT	0.512		NA											29	62	---	---	---	---	NA	NA	NA	NA
ZNF654	55279	broad.mit.edu	37	3	88188748	88188750	+	In_Frame_Del	DEL	TAC	TAC	-			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:88188748_88188750delTAC	uc003dqv.2	+	1	487_489	c.288_290delTAC	c.(286-291)CTTACT>CTT	p.T97del	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGGAGACACTTACTGCTTCTAGT	0.34		NA											12	32	---	---	---	---	NA	NA	NA	NA
DOK7	285489	broad.mit.edu	37	4	3494760	3494783	+	In_Frame_Del	DEL	CAGCAGCCTCTCGTCCTACGCGGG	CAGCAGCCTCTCGTCCTACGCGGG	-			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:3494760_3494783delCAGCAGCCTCTCGTCCTACGCGGG	uc003ghd.2	+	7	1117_1140	c.1047_1070delCAGCAGCCTCTCGTCCTACGCGGG	c.(1045-1071)TCCAGCAGCCTCTCGTCCTACGCGGGC>TCC	p.SSLSSYAG350del	DOK7_uc003ghe.2_In_Frame_Del_p.SSLSSYAG212del|DOK7_uc003ghf.2_In_Frame_Del_p.AASRPTRA92del|DOK7_uc003ghg.1_In_Frame_Del_p.SSLSSYAG40del	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	350_357	Ser-rich.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTCTTACTCCAGCAGCCTCTCGTCCTACGCGGGCAGCAGCCTG	0.714		NA											3	5	---	---	---	---	NA	NA	NA	NA
FBXW7	55294	broad.mit.edu	37	4	153259045	153259046	+	Frame_Shift_Ins	INS	-	-	TGAGT			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:153259045_153259046insTGAGT	uc003ims.2	-	5	918_919	c.769_770insACTCA	c.(769-771)ATTfs	p.I257fs	FBXW7_uc011cii.1_Frame_Shift_Ins_p.I257fs|FBXW7_uc003imt.2_Frame_Shift_Ins_p.I257fs|FBXW7_uc011cih.1_Frame_Shift_Ins_p.I81fs|FBXW7_uc003imq.2_Frame_Shift_Ins_p.I177fs|FBXW7_uc003imr.2_Frame_Shift_Ins_p.I139fs	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	257					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACAACTATCAATGAGTTCATCT	0.356		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								14	40	---	---	---	---	NA	NA	NA	NA
