Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
VPS13D	55187	broad.mit.edu	37	1	12443108	12443108	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:12443108T>G	uc001atv.2	+	58	11405	c.11264T>G	c.(11263-11265)TTG>TGG	p.L3755W	VPS13D_uc001atw.2_Missense_Mutation_p.L3730W|VPS13D_uc001atx.2_Missense_Mutation_p.L2942W|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3754					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATGGAGCTTTTGGGGCCAGTT	0.433		NA											49	102					0	0	0	0
EIF4G3	8672	broad.mit.edu	37	1	21186878	21186878	+	Missense_Mutation	SNP	C	C	A	rs10916883		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:21186878C>A	uc001bec.2	-	19	3332	c.3076G>T	c.(3076-3078)GGT>TGT	p.G1026C	EIF4G3_uc010odi.1_Missense_Mutation_p.G630C|EIF4G3_uc010odj.1_Missense_Mutation_p.G1025C|EIF4G3_uc009vpz.2_Missense_Mutation_p.G746C|EIF4G3_uc001bed.2_Missense_Mutation_p.G1026C|EIF4G3_uc001bef.2_Missense_Mutation_p.G1062C|EIF4G3_uc001bee.2_Missense_Mutation_p.G1032C	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1026					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CCGGCCTCACCTGGTCTTCTC	0.393		NA											39	108					2.48e-24	4.79e-24	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35919263	35919264	+	Missense_Mutation	DNP	GC	GC	CG			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:35919263_35919264GC>CG	uc001byx.2	-	12	2065_2066	c.1807_1808GC>CG	c.(1807-1809)GCA>CGA	p.A603R	KIAA0319L_uc001byw.2_Missense_Mutation_p.A40R|KIAA0319L_uc010ohv.1_Missense_Mutation_p.A245R	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	603	PKD 4.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCTGGGCCTGCATCTGCCTGA	0.475		NA											8	39					0	0	0	0
SLC2A1	6513	broad.mit.edu	37	1	43396789	43396789	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:43396789G>A	uc001cik.2	-	3	728	c.203C>T	c.(202-204)TCA>TTA	p.S68L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	68	Helical; Name=2; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	GATGGCCACTGAGAGGGACCA	0.592		NA									OREG0013425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	55					0	0	0	0
C8A	731	broad.mit.edu	37	1	57378266	57378266	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:57378266T>G	uc001cyo.2	+	10	1703	c.1571T>G	c.(1570-1572)TTG>TGG	p.L524W		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	524	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGGTAGCTTGGGTGCTGCC	0.592		NA											11	82					0	0	0	0
GBP7	388646	broad.mit.edu	37	1	89616203	89616203	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:89616203G>T	uc001dna.2	-	6	820	c.681C>A	c.(679-681)TTC>TTA	p.F227L	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	227						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GTTTTGGAAAGAAATGCCTGA	0.393		NA											37	50					8.74e-17	1.68e-16	1	0
CLK2	1196	broad.mit.edu	37	1	155234561	155234561	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:155234561C>T	uc001fjy.2	-	9	1228	c.938G>A	c.(937-939)CGA>CAA	p.R313Q	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.R312Q|CLK2_uc001fjx.2_Missense_Mutation_p.R85Q|CLK2_uc009wqm.2_Missense_Mutation_p.R313Q	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	313	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCGCTCATCTCGCTTCTAGGA	0.507		NA						Other_conserved_DNA_damage_response_genes					27	31					0	0	0	0
ETV3L	440695	broad.mit.edu	37	1	157062482	157062482	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:157062482G>C	uc001fqq.1	-	5	1330	c.1045C>G	c.(1045-1047)CTG>GTG	p.L349V		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	349						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				AGGTTCTCCAGATTGGGGGAA	0.562		NA											5	53					0	0	0	0
MNDA	4332	broad.mit.edu	37	1	158817523	158817523	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:158817523C>T	uc001fsz.1	+	6	1193	c.993C>T	c.(991-993)AGC>AGT	p.S331S		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	331	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TGCAGAAAAGCGTACACAAGA	0.368		NA											9	40					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197115515	197115515	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:197115515C>T	uc001gtu.2	-	1	310	c.53G>A	c.(52-54)CGG>CAG	p.R18Q	ASPM_uc001gtv.2_Missense_Mutation_p.R18Q|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	18					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						gggcggcctccgctcggtcgg	0.154		NA											10	44					0	0	0	0
ELF3	1999	broad.mit.edu	37	1	201981088	201981088	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:201981088A>G	uc001gxg.3	+	2	3359	c.167A>G	c.(166-168)AAG>AGG	p.K56R	ELF3_uc001gxi.3_Missense_Mutation_p.K56R|ELF3_uc001gxh.3_Missense_Mutation_p.K56R	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	56	PNT.			EK -> GE (in Ref. 7; CAD29859).	epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CTTGCAGAGAAGGCCAGCTGG	0.498		NA											70	110					0	0	0	0
PTPN7	5778	broad.mit.edu	37	1	202121757	202121757	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:202121757G>A	uc001gxm.1	-	8	919	c.788C>T	c.(787-789)TCA>TTA	p.S263L	PTPN7_uc001gxl.1_Missense_Mutation_p.S302L|PTPN7_uc001gxn.1_Missense_Mutation_p.S263L|PTPN7_uc010ppv.1_Missense_Mutation_p.S82L|PTPN7_uc010ppw.1_Missense_Mutation_p.S211L|PTPN7_uc010ppx.1_Missense_Mutation_p.S337L|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_Missense_Mutation_p.S215L	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	263	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						GGGCCCAGCTGATTCTGGTGT	0.622		NA											23	45					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16911693	16911693	+	Silent	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr10:16911693G>A	uc001ioo.2	-	59	9448	c.9396C>T	c.(9394-9396)TTC>TTT	p.F3132F	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Silent_p.F488F	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3132	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AATCTGTCTTGAACACCAGGA	0.453		NA											37	147					0	0	0	0
C11orf41	25758	broad.mit.edu	37	11	33667250	33667250	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:33667250G>A	uc001mup.3	+	16	4679	c.4555G>A	c.(4555-4557)GAG>AAG	p.E1519K		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1513						integral to membrane				ovary(2)	2						TGAAATCATAGAGGAAACCAA	0.463		NA											27	84					0	0	0	0
RASGRP2	10235	broad.mit.edu	37	11	64508539	64508539	+	Silent	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:64508539G>A	uc009ypu.2	-	5	479	c.252C>T	c.(250-252)TCC>TCT	p.S84S	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'UTR|RASGRP2_uc009ypv.2_Silent_p.S84S|RASGRP2_uc009ypw.2_Silent_p.S84S	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	84	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CTGGGAAGGCGGAGATCCAGT	0.572		NA									OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	24					0	0	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64606237	64606237	+	Silent	SNP	T	T	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:64606237T>C	uc001obs.3	-	8	1014	c.1014A>G	c.(1012-1014)GAA>GAG	p.E338E		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	338	AGC-kinase C-terminal.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						AGTCCACGCCTTCGAAGAAAG	0.637		NA											29	66					0	0	0	0
OMP	4975	broad.mit.edu	37	11	76813990	76813990	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:76813990C>T	uc010rsk.1	+	1	105	c.105C>T	c.(103-105)CGC>CGT	p.R35R	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	35					sensory perception of smell|synaptic transmission						0						TGAAGCAGCGCGGGGAGAAGC	0.672		NA											17	27					0	0	0	0
CDKN1B	1027	broad.mit.edu	37	12	12870859	12870859	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:12870859G>T	uc001rat.2	+	1	558	c.86G>T	c.(85-87)TGC>TTC	p.C29F		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	29					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CCCTCGGCCTGCAGGAACCTC	0.617		NA							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				37	71					1.91e-15	3.64e-15	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21032551	21032551	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:21032551C>T	uc001rek.2	+	10	1443	c.1317C>T	c.(1315-1317)ACC>ACT	p.T439T	SLCO1B3_uc001rel.2_Silent_p.T439T|SLCO1B3_uc010sil.1_Silent_p.T439T|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.T264T	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	439	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCGGCCTAACCTTGACCTATG	0.313		NA											18	47					0	0	0	0
GYS2	2998	broad.mit.edu	37	12	21693480	21693480	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:21693480C>T	uc001rfb.2	-	14	1928	c.1673G>A	c.(1672-1674)CGT>CAT	p.R558H		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	558					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATCTGGAGAACGGAACCGCCT	0.418		NA											16	101					0	0	0	0
CNTN1	1272	broad.mit.edu	37	12	41421672	41421672	+	Silent	SNP	T	T	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:41421672T>A	uc001rmm.1	+	22	2837	c.2724T>A	c.(2722-2724)CCT>CCA	p.P908P	CNTN1_uc001rmn.1_Silent_p.P897P	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	908	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTAGCCAGCCTCCAAGGATCA	0.408		NA											20	31					0	0	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54115808	54115808	+	Splice_Site	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:54115808C>T	uc001sef.2	-	5	753	c.609_splice	c.e5+1	p.K203_splice	CALCOCO1_uc010som.1_Splice_Site_p.K170_splice|CALCOCO1_uc010son.1_Splice_Site_p.K80_splice|CALCOCO1_uc001seh.2_Splice_Site_p.K203_splice|CALCOCO1_uc009znd.2_Splice_Site_p.K203_splice|CALCOCO1_uc001seg.2_Splice_Site_p.K80_splice|CALCOCO1_uc010soo.1_Splice_Site_p.K196_splice	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform						steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCAGCTCCCACCTTGTACTGT	0.597		NA											8	68					0	0	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54117433	54117433	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:54117433C>T	uc001sef.2	-	4	538	c.394G>A	c.(394-396)GAG>AAG	p.E132K	CALCOCO1_uc010som.1_Missense_Mutation_p.E99K|CALCOCO1_uc010son.1_Missense_Mutation_p.E9K|CALCOCO1_uc001seh.2_Missense_Mutation_p.E132K|CALCOCO1_uc009znd.2_Missense_Mutation_p.E132K|CALCOCO1_uc001seg.2_Missense_Mutation_p.E9K|CALCOCO1_uc010soo.1_Missense_Mutation_p.E125K	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	132	N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCATCAGCCTCCTCCAGGGTC	0.577		NA											8	66					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72680609	72680609	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:72680609G>A	uc001sxa.2	+	2	958	c.928G>A	c.(928-930)GTG>ATG	p.V310M		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	310	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGAAACTTCCGTGTTTGAGGA	0.403		NA											56	85					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120172977	120172977	+	Silent	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:120172977G>A	uc001txi.1	-	24	3071	c.3018C>T	c.(3016-3018)ACC>ACT	p.T1006T	CIT_uc001txh.1_Silent_p.T540T|CIT_uc001txj.1_Silent_p.T1048T	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1006	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GCTTCTGGCTGGTAAGCTGCA	0.522		NA											16	79					0	0	0	0
CAMKK2	10645	broad.mit.edu	37	12	121691083	121691083	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:121691083G>C	uc001tzu.2	-	10	1224	c.1100C>G	c.(1099-1101)TCT>TGT	p.S367C	CAMKK2_uc001tzt.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzv.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzw.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzx.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzy.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzz.1_Missense_Mutation_p.S154C|CAMKK2_uc001uaa.1_Missense_Mutation_p.S367C|CAMKK2_uc001uab.2_Missense_Mutation_p.S367C|CAMKK2_uc001uac.2_Missense_Mutation_p.S367C	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	367	Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TACCTTCCCAGAGAAGATCTT	0.433		NA											4	56					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124413860	124413860	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:124413860G>A	uc001uft.3	+	70	12016	c.11991G>A	c.(11989-11991)ATG>ATA	p.M3997I	DNAH10_uc001ufu.3_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3997	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AACTCAACATGAGGGCAACTT	0.537		NA											4	16					0	0	0	0
C13orf28	122258	broad.mit.edu	37	13	113030784	113030784	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr13:113030784G>A	uc001vsd.1	+	1	116	c.85G>A	c.(85-87)GTG>ATG	p.V29M		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	29						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					GCCGAGAACCGTGATTCCAGG	0.592		NA											17	10					0	0	0	0
OR4M1	441670	broad.mit.edu	37	14	20248671	20248671	+	Missense_Mutation	SNP	G	G	T	rs114064896	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:20248671G>T	uc010tku.1	+	1	190	c.190G>T	c.(190-192)GCT>TCT	p.A64S		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCCTGTTGGCTAATCTGGC	0.408		NA											28	442					2.61e-14	4.95e-14	1	0
METT11D1	64745	broad.mit.edu	37	14	21464085	21464085	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:21464085C>A	uc001vyn.2	+	11	1168	c.971C>A	c.(970-972)CCT>CAT	p.P324H	METT11D1_uc001vym.2_Missense_Mutation_p.P324H|METT11D1_uc001vyo.2_Missense_Mutation_p.P324H|METT11D1_uc001vyp.2_Missense_Mutation_p.P166H|METT11D1_uc001vyq.2_Missense_Mutation_p.P166H	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	324					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CCTTTGGACCCTCGACCTGGT	0.453		NA											15	454					2e-07	3.69e-07	1	0
NID2	22795	broad.mit.edu	37	14	52481133	52481133	+	Silent	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:52481133G>T	uc001wzo.2	-	16	3526	c.3292C>A	c.(3292-3294)CGG>AGG	p.R1098R	NID2_uc010tqs.1_Silent_p.R1050R|NID2_uc010tqt.1_Silent_p.R1098R|NID2_uc001wzp.2_Silent_p.R1098R	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1098						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ACATCTGGCCGGGGCGTGGGC	0.617		NA									OREG0022678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	30					2.38e-13	4.49e-13	1	0
DAAM1	23002	broad.mit.edu	37	14	59791160	59791160	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:59791160C>G	uc001xdz.1	+	8	1102	c.977C>G	c.(976-978)TCA>TGA	p.S326*	DAAM1_uc001xea.1_Nonsense_Mutation_p.S326*|DAAM1_uc001xeb.1_Nonsense_Mutation_p.S326*	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	326	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CACGAAAATTCAACATTAGAT	0.308		NA											3	49					0	0	0	0
DCAF4	26094	broad.mit.edu	37	14	73408452	73408452	+	Splice_Site	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:73408452G>C	uc001xng.2	+	5	572	c.352_splice	c.e5-1	p.I118_splice	DCAF4_uc001xnj.2_Splice_Site_p.I118_splice|DCAF4_uc010ttr.1_Splice_Site_p.I96_splice|DCAF4_uc001xnh.2_Splice_Site_p.I18_splice|DCAF4_uc010tts.1_Intron|DCAF4_uc010ttt.1_Splice_Site|DCAF4_uc001xni.2_Intron|DCAF4_uc001xnk.2_Splice_Site_p.I118_splice	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1							CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AATAAATATAGATTGCCAGGA	0.368		NA											39	75					0	0	0	0
OTUB2	78990	broad.mit.edu	37	14	94511065	94511065	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:94511065G>A	uc001yci.2	+	5	597	c.437G>A	c.(436-438)CGA>CAA	p.R146Q		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	146	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		ATCAGGAACCGAGCAGACTTC	0.587		NA											19	25					0	0	0	0
TCL1A	8115	broad.mit.edu	37	14	96178699	96178699	+	Missense_Mutation	SNP	C	C	T	rs146705048	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:96178699C>T	uc001yfc.3	-	2	285	c.155G>A	c.(154-156)CGT>CAT	p.R52H	TCL1A_uc001yfb.3_Missense_Mutation_p.R52H	NM_001098725	NP_001092195	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	52					multicellular organismal development	endoplasmic reticulum|microsome				lung(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GTCTTCCCGACGCAAGAGCAC	0.567		NA	T	TRA@	T-CLL								21	96					0	0	0	0
DUOX1	53905	broad.mit.edu	37	15	45433157	45433157	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:45433157G>A	uc001zus.1	+	14	1800	c.1454G>A	c.(1453-1455)GGA>GAA	p.G485E	DUOX1_uc001zut.1_Missense_Mutation_p.G485E|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	485	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTCCCTGGGGGACTCCTGGAG	0.572		NA											27	79					0	0	0	0
MYO5A	4644	broad.mit.edu	37	15	52632529	52632529	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:52632529C>A	uc002aby.2	-	32	4347	c.4103G>T	c.(4102-4104)CGT>CTT	p.R1368L	MYO5A_uc002abx.3_Missense_Mutation_p.R1341L|MYO5A_uc010ugd.1_Missense_Mutation_p.R90L|MYO5A_uc002abz.1_RNA|MYO5A_uc002aca.1_Missense_Mutation_p.R120L|MYO5A_uc002acb.1_Missense_Mutation_p.R93L|MYO5A_uc002acc.1_Missense_Mutation_p.R117L	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1368	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GATCTCCCCACGGAGGGCCTC	0.637		NA											19	82					5.04e-11	9.44e-11	1	0
HERC1	8925	broad.mit.edu	37	15	63978604	63978604	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:63978604T>C	uc002amp.2	-	34	6327	c.6179A>G	c.(6178-6180)TAT>TGT	p.Y2060C		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2060	B30.2/SPRY.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGCCAATCCATATCCTTTCCC	0.408		NA											80	143					0	0	0	0
C15orf44	81556	broad.mit.edu	37	15	65888131	65888131	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:65888131C>T	uc002apd.2	-	7	1117	c.781G>A	c.(781-783)GAT>AAT	p.D261N	C15orf44_uc010uix.1_Missense_Mutation_p.D297N|C15orf44_uc010uiz.1_Missense_Mutation_p.D225N|C15orf44_uc010uja.1_Missense_Mutation_p.D212N|C15orf44_uc010ujb.1_Missense_Mutation_p.D182N|C15orf44_uc002ape.3_Missense_Mutation_p.D261N|C15orf44_uc010uiy.1_Missense_Mutation_p.D182N	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	261										ovary(1)	1						CTTGAAATATCAGCTATATCA	0.353		NA											7	32					0	0	0	0
MYO9A	4649	broad.mit.edu	37	15	72244166	72244166	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72244166G>A	uc002atl.3	-	15	2727	c.2254C>T	c.(2254-2256)CAC>TAC	p.H752Y	MYO9A_uc010biq.2_Missense_Mutation_p.H347Y|MYO9A_uc002atn.1_Missense_Mutation_p.H733Y	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	752					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CTCCTCTGGTGGACTGGGTGT	0.373		NA											24	134					0	0	0	0
PKM2	5315	broad.mit.edu	37	15	72509817	72509817	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72509817G>A	uc002atx.1	-	3	420	c.179C>T	c.(178-180)ACG>ATG	p.T60M	PKM2_uc010bit.1_Missense_Mutation_p.T65M|PKM2_uc010uki.1_Missense_Mutation_p.T134M|PKM2_uc002atv.1_Missense_Mutation_p.T95M|PKM2_uc002atw.1_Missense_Mutation_p.T60M|PKM2_uc002aty.1_Missense_Mutation_p.T60M|PKM2_uc010ukj.1_Intron|PKM2_uc010ukk.1_Intron|PKM2_uc010biu.1_Missense_Mutation_p.T81M|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	60					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CTCCTTCAACGTCTCCACTGA	0.408		NA											13	69					0	0	0	0
ARIH1	25820	broad.mit.edu	37	15	72873104	72873104	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72873104C>G	uc002aut.3	+	12	1562	c.1248C>G	c.(1246-1248)TTC>TTG	p.F416L		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	416					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						GGTACCTGTTCTACTGTAATC	0.413		NA											7	43					0	0	0	0
TSC2	7249	broad.mit.edu	37	16	2121792	2121792	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:2121792G>C	uc002con.2	+	19	2060	c.1954G>C	c.(1954-1956)GAG>CAG	p.E652Q	TSC2_uc010bsd.2_Missense_Mutation_p.E652Q|TSC2_uc002coo.2_Missense_Mutation_p.E652Q|TSC2_uc010uvv.1_Missense_Mutation_p.E615Q|TSC2_uc010uvw.1_Missense_Mutation_p.E603Q|TSC2_uc002cop.2_Missense_Mutation_p.E452Q	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	652					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CAGGGAGCCAGAGAGAGGCTC	0.662		NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				3	13					0	0	0	0
TRAF7	84231	broad.mit.edu	37	16	2218133	2218133	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:2218133C>T	uc002cow.2	+	4	294	c.195C>T	c.(193-195)ACC>ACT	p.T65T		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	65					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						CCTCCAGCACCCTTGCCTACT	0.672		NA											5	17					0	0	0	0
TAOK2	9344	broad.mit.edu	37	16	30002132	30002132	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:30002132G>A	uc002dvc.1	+	18	3256	c.2473G>A	c.(2473-2475)GAG>AAG	p.E825K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	704	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCAGGAGGCAGAGTTCCAGGC	0.602		NA											9	54					0	0	0	0
CTCF	10664	broad.mit.edu	37	16	67660529	67660529	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:67660529C>T	uc002etl.2	+	8	1719	c.1429C>T	c.(1429-1431)CAT>TAT	p.H477Y	CTCF_uc010cek.2_Missense_Mutation_p.H149Y|CTCF_uc002etm.1_5'Flank	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	477	C2H2-type 8.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TGCTGTGTTTCATGAGCGCTA	0.463		NA											11	48					0	0	0	0
CDH13	1012	broad.mit.edu	37	16	83159053	83159053	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:83159053C>T	uc002fgx.2	+	4	550	c.430C>T	c.(430-432)CCC>TCC	p.P144S	CDH13_uc010chh.2_Missense_Mutation_p.P144S|CDH13_uc010vns.1_Missense_Mutation_p.P191S|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Intron	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	144	Cadherin 1.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGTGGTATCTCCCATTTTAAT	0.363		NA											14	28					0	0	0	0
FBXO31	79791	broad.mit.edu	37	16	87365041	87365041	+	Silent	SNP	G	G	A	rs141426651		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:87365041G>A	uc002fjw.2	-	9	1517	c.1473C>T	c.(1471-1473)TTC>TTT	p.F491F	FBXO31_uc010vot.1_Silent_p.F319F|FBXO31_uc002fjv.2_Silent_p.F383F	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	491					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GGTCCTCATCGAAGAGGATGA	0.612		NA											11	24					0	0	0	0
ASGR1	432	broad.mit.edu	37	17	7077514	7077514	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:7077514G>T	uc002ges.3	-	7	947	c.537C>A	c.(535-537)GAC>GAA	p.D179E	ASGR1_uc010clx.1_Missense_Mutation_p.D78E	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	179	Extracellular (Probable).|C-type lectin.				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GGCAGTAGTTGTCGGCGTCAG	0.677		NA											42	60					4.44e-20	8.56e-20	1	0
TP53	7157	broad.mit.edu	37	17	7577141	7577141	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:7577141C>T	uc002gim.2	-	8	991	c.797G>A	c.(796-798)GGA>GAA	p.G266E	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134E|TP53_uc010cng.1_Missense_Mutation_p.G134E|TP53_uc002gii.1_Missense_Mutation_p.G134E|TP53_uc010cnh.1_Missense_Mutation_p.G266E|TP53_uc010cni.1_Missense_Mutation_p.G266E|TP53_uc002gij.2_Missense_Mutation_p.G266E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(32)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	10					0	0	0	0
AURKB	9212	broad.mit.edu	37	17	8108663	8108663	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:8108663C>T	uc002gkm.2	-	8	793	c.732G>A	c.(730-732)ATG>ATA	p.M244I	AURKB_uc010cnu.2_Missense_Mutation_p.M64I|AURKB_uc002gkn.2_Missense_Mutation_p.M245I|AURKB_uc010vuu.1_Missense_Mutation_p.M203I|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	244	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						GCCCCTCAATCATCTCTGGGG	0.562		NA											14	64					0	0	0	0
GOSR1	9527	broad.mit.edu	37	17	28811740	28811740	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:28811740G>C	uc002hfe.2	+	4	326	c.300G>C	c.(298-300)TTG>TTC	p.L100F	GOSR1_uc002hfd.2_Missense_Mutation_p.L98F|GOSR1_uc002hff.2_Missense_Mutation_p.L35F|GOSR1_uc002hfc.1_Missense_Mutation_p.L100F	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	100	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						TCCCCTCCTTGAATGCAGCCC	0.363		NA											7	44					0	0	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36927374	36927374	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:36927374T>A	uc002hqs.2	-	8	1440	c.959A>T	c.(958-960)TAT>TTT	p.Y320F	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	320	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						AGGTGTGCCATAGGAGCAGAG	0.448		NA											19	47					0	0	0	0
KRT23	25984	broad.mit.edu	37	17	39086308	39086308	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:39086308C>G	uc002hvm.1	-	4	1109	c.520G>C	c.(520-522)GAA>CAA	p.E174Q	KRT23_uc010wfl.1_Missense_Mutation_p.E37Q|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Missense_Mutation_p.E174Q|KRT23_uc002hvn.1_Missense_Mutation_p.E174Q	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	174	Rod.|Coil 1B.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				CCCTCGACTTCAATTTCCAAG	0.443		NA											21	95					0	0	0	0
DUSP3	1845	broad.mit.edu	37	17	41847077	41847077	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:41847077A>G	uc002ied.3	-	3	534	c.458T>C	c.(457-459)ATC>ACC	p.I153T	DUSP3_uc002iee.3_3'UTR|DUSP3_uc002ief.1_Missense_Mutation_p.I110T	NM_004090	NP_004081	P51452	DUS3_HUMAN	dual specificity phosphatase 3	153	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		CTGCCTCACGATGCTCAGGGC	0.582		NA											9	53					0	0	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626223	44626223	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:44626223G>C	uc002ikn.1	+	9	3721	c.3718G>C	c.(3718-3720)GAG>CAG	p.E1240Q	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Missense_Mutation_p.E201Q|LRRC37A2_uc010dax.1_Missense_Mutation_p.E170Q	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1240	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		CTTCACCCAAGAGCATAAGGC	0.592		NA											17	223					0	0	0	0
CCDC46	201134	broad.mit.edu	37	17	63847958	63847958	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:63847958C>G	uc002jfl.2	-	21	2577	c.2358G>C	c.(2356-2358)AAG>AAC	p.K786N	CCDC46_uc010deo.2_Missense_Mutation_p.K528N|CCDC46_uc002jfm.2_Missense_Mutation_p.K786N|CCDC46_uc010dep.2_Missense_Mutation_p.K744N	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	786	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CAGCATGAGTCTTTTTCAGCT	0.373		NA											24	150					0	0	0	0
MRPS7	51081	broad.mit.edu	37	17	73258060	73258060	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:73258060C>G	uc002jnm.3	+	1	312	c.79C>G	c.(79-81)CCA>GCA	p.P27A	GGA3_uc002jni.1_5'Flank|GGA3_uc002jnj.1_5'Flank|GGA3_uc010wrw.1_Intron|GGA3_uc002jnk.1_5'Flank|GGA3_uc010wrx.1_5'Flank|GGA3_uc010wry.1_Intron|GGA3_uc010wrz.1_5'Flank|MRPS7_uc002jnl.2_Missense_Mutation_p.P27A|MRPS7_uc002jnn.3_5'UTR	NM_015971	NP_057055	Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7 precursor	27					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CTTGCAGCTTCCAGGGTGAGA	0.592		NA											10	61					0	0	0	0
DTNA	1837	broad.mit.edu	37	18	32457760	32457760	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:32457760G>C	uc010dmn.1	+	18	1901	c.1900G>C	c.(1900-1902)GAG>CAG	p.E634Q	DTNA_uc002kxw.2_Missense_Mutation_p.E577Q|DTNA_uc010dmj.2_Missense_Mutation_p.E574Q|DTNA_uc002kxz.2_Missense_Mutation_p.E581Q|DTNA_uc002kxy.2_Missense_Mutation_p.E574Q|DTNA_uc010xby.1_Missense_Mutation_p.E324Q|DTNA_uc010xbz.1_Missense_Mutation_p.E343Q|DTNA_uc010xca.1_Missense_Mutation_p.E286Q|DTNA_uc002kye.2_Missense_Mutation_p.E282Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	634					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TCTTGTGAAAGAGCTGAATTC	0.423		NA											6	27					0	0	0	0
LIPG	9388	broad.mit.edu	37	18	47107900	47107900	+	Silent	SNP	C	C	T	rs75308718		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:47107900C>T	uc002ldv.2	+	6	1161	c.909C>T	c.(907-909)TTC>TTT	p.F303F	LIPG_uc002ldu.1_Silent_p.F303F|LIPG_uc010xdh.1_Silent_p.F229F	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	303					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CCAATCGCTTCAAAAAGGGGA	0.468		NA											17	116					0	0	0	0
WDR7	23335	broad.mit.edu	37	18	54358527	54358527	+	Silent	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:54358527C>G	uc002lgk.1	+	8	1009	c.798C>G	c.(796-798)GTC>GTG	p.V266V	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.V266V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	266										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGGACTTTGTCTCATCAGATA	0.418		NA											35	58					0	0	0	0
NFIC	4782	broad.mit.edu	37	19	3452481	3452481	+	Silent	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:3452481G>T	uc010xhi.1	+	8	1148	c.1086G>T	c.(1084-1086)GGG>GGT	p.G362G	NFIC_uc002lxo.2_Silent_p.G353G|NFIC_uc010xhh.1_Silent_p.G353G|NFIC_uc002lxp.2_Silent_p.G362G|NFIC_uc010xhj.1_Silent_p.G362G	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	362					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		TCTCCGCAGGGATCGCCCGGA	0.647		NA											52	181					1.46e-29	2.85e-29	1	0
GIPC3	126326	broad.mit.edu	37	19	3586841	3586841	+	Silent	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:3586841G>A	uc002lyd.3	+	3	468	c.441G>A	c.(439-441)CGG>CGA	p.R147R		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	147	PDZ.									breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATCAACCGGATCGAGGCAG	0.622		NA									OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	15					0	0	0	0
SEMA6B	10501	broad.mit.edu	37	19	4552583	4552583	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:4552583C>T	uc010duc.1	-	9	878	c.840G>A	c.(838-840)AAG>AAA	p.K280K	SEMA6B_uc010dud.2_Silent_p.K280K|SEMA6B_uc010xih.1_Silent_p.K280K	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	280	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGTCCACTGCTTCTCCAGCA	0.657		NA											10	12					0	0	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964812	7964812	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:7964812C>T	uc002mir.2	+	3	1506	c.1405C>T	c.(1405-1407)CAC>TAC	p.H469Y		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	469						integral to membrane				lung(1)|pancreas(1)	2						CAGCTTGCTCCACTCGCCCGC	0.632		NA											9	22					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17737530	17737530	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:17737530T>C	uc002nhd.2	-	34	4249	c.4249A>G	c.(4249-4251)ACA>GCA	p.T1417A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1329					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						ACATTGCCTGTGCCCTTAACC	0.592		NA											8	12					0	0	0	0
KLHL26	55295	broad.mit.edu	37	19	18778789	18778789	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:18778789G>C	uc002njz.1	+	3	609	c.582G>C	c.(580-582)CAG>CAC	p.Q194H		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	194	BACK.									ovary(1)	1						ACTTCCTGCAGATCGCCGAGG	0.637		NA											9	50					0	0	0	0
ZNF101	94039	broad.mit.edu	37	19	19790800	19790800	+	Silent	SNP	A	A	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:19790800A>T	uc002nni.1	+	4	1112	c.1002A>T	c.(1000-1002)GGA>GGT	p.G334G	ZNF101_uc010ecg.1_Silent_p.G214G|ZNF101_uc002nnj.1_Silent_p.G214G	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCACACTGGAGAAAGACCTT	0.368		NA											6	31					0	0	0	0
ZNF430	80264	broad.mit.edu	37	19	21239886	21239886	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:21239886G>C	uc002npj.2	+	5	882	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	ZNF430_uc002npk.2_Missense_Mutation_p.E257Q	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						TCATACTGGAGAGAAACCCTA	0.368		NA											5	50					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40408042	40408042	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:40408042T>A	uc002omp.3	-	9	4687	c.4679A>T	c.(4678-4680)GAT>GTT	p.D1560V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1560	TIL 3.|Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGCACACCCATCCTGGCACTG	0.617		NA											12	40					0	0	0	0
HIF3A	64344	broad.mit.edu	37	19	46808523	46808523	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:46808523C>G	uc002peh.2	+	3	268	c.239C>G	c.(238-240)GCA>GGA	p.A80G	HIF3A_uc002pef.1_Missense_Mutation_p.A80G|HIF3A_uc002peg.3_Missense_Mutation_p.A80G|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.A24G|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Missense_Mutation_p.A24G|HIF3A_uc010xxy.1_Intron|HIF3A_uc002pel.2_Missense_Mutation_p.A78G|HIF3A_uc010xxz.1_Intron	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CAGGTGGGAGCAGGGGGAGAA	0.617		NA											18	81					0	0	0	0
LENG8	114823	broad.mit.edu	37	19	54968931	54968931	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:54968931G>C	uc002qfv.1	+	11	1770	c.1626G>C	c.(1624-1626)TTG>TTC	p.L542F	LENG8_uc002qfw.2_Missense_Mutation_p.L579F			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	542							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		TTCAGGTTTTGAAAAAGTCGC	0.493		NA											11	87					0	0	0	0
ZNF264	9422	broad.mit.edu	37	19	57705330	57705330	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:57705330G>C	uc002qob.2	+	2	534	c.121G>C	c.(121-123)GAG>CAG	p.E41Q		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CCTGTACCAGGAGGTGATGCT	0.557		NA											23	107					0	0	0	0
ZNF418	147686	broad.mit.edu	37	19	58438232	58438232	+	Silent	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:58438232G>T	uc002qqs.1	-	4	1609	c.1317C>A	c.(1315-1317)GGC>GGA	p.G439G	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Silent_p.G354G	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	439	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GAATGAGGTTGCCCTTTCGAC	0.473		NA											41	149					1.59e-14	3.04e-14	1	0
C2orf16	84226	broad.mit.edu	37	2	27803074	27803074	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:27803074C>T	uc002rkz.3	+	1	3686	c.3635C>T	c.(3634-3636)ACT>ATT	p.T1212I	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1212										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAGAGTCCTACTTCCACAATA	0.468		NA											20	107					0	0	0	0
LRPPRC	10128	broad.mit.edu	37	2	44209427	44209427	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:44209427C>T	uc002rtr.2	-	2	354	c.296G>A	c.(295-297)CGC>CAC	p.R99H	LRPPRC_uc010yob.1_Intron|LRPPRC_uc010faw.1_Missense_Mutation_p.R73H	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	99					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTTTGGAATGCGGCCAGTTCT	0.338		NA											9	44					0	0	0	0
XPO1	7514	broad.mit.edu	37	2	61711150	61711150	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:61711150G>A	uc002sbj.2	-	21	3327	c.2599C>T	c.(2599-2601)CCA>TCA	p.P867S	XPO1_uc010fcl.2_Missense_Mutation_p.P863S|XPO1_uc010ypn.1_Missense_Mutation_p.P863S|XPO1_uc002sbk.2_Missense_Mutation_p.P428S|XPO1_uc002sbg.2_Missense_Mutation_p.P64S|XPO1_uc002sbh.2_Missense_Mutation_p.P514S	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	867					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TGTGTAGGTGGAATAGCAAGG	0.348		NA											13	71					0	0	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96993068	96993068	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:96993068G>C	uc002svx.2	+	3	1034	c.699G>C	c.(697-699)CAG>CAC	p.Q233H	ITPRIPL1_uc010yuk.1_Missense_Mutation_p.Q225H|ITPRIPL1_uc002svy.2_Missense_Mutation_p.Q241H|ITPRIPL1_uc010yul.1_Missense_Mutation_p.Q225H	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	233	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						ATGAGACCCAGAAATTTGATA	0.612		NA											18	48					0	0	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257054	114257054	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:114257054T>A	uc002tjw.3	+	1	394	c.221T>A	c.(220-222)ATC>AAC	p.I74N		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	74					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CGAGAGCACATCGAGGGCGGC	0.647		NA											19	41					0	0	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122038715	122038715	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:122038715C>T	uc002tmx.2	-	2	288	c.195G>A	c.(193-195)ACG>ACA	p.T65T	TFCP2L1_uc010flr.2_Silent_p.T65T	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	65					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GGTAGGTCAGCGTCTCTTCAT	0.627		NA											12	69					0	0	0	0
DPP4	1803	broad.mit.edu	37	2	162902113	162902113	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:162902113C>G	uc002ubz.2	-	5	856	c.295G>C	c.(295-297)GGA>CGA	p.G99R	DPP4_uc010fpb.2_5'UTR|DPP4_uc002uca.1_RNA|DPP4_uc002ucb.1_RNA	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	99	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	ATAGAATGTCCAAACTCATCC	0.343		NA											12	46					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179424503	179424503	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:179424503C>G	uc010zfg.1	-	275	78876	c.78652G>C	c.(78652-78654)GTC>CTC	p.V26218L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V19913L|TTN_uc010zfi.1_Missense_Mutation_p.V19846L|TTN_uc010zfj.1_Missense_Mutation_p.V19721L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27145							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCACAAGACATTGGGTACT	0.438		NA											38	93					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179456614	179456614	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:179456614G>C	uc010zfg.1	-	252	52452	c.52228C>G	c.(52228-52230)CCA>GCA	p.P17410A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11105A|TTN_uc010zfi.1_Missense_Mutation_p.P11038A|TTN_uc010zfj.1_Missense_Mutation_p.P10913A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18337							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGCCCTGGGGGATCTTTT	0.428		NA											3	65					0	0	0	0
DES	1674	broad.mit.edu	37	2	220286275	220286275	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:220286275G>T	uc002vll.2	+	6	1323	c.1237G>T	c.(1237-1239)GAG>TAG	p.E413*		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	413	Tail.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGAGGGAGAGGAGAGCCGGTG	0.622		NA											14	44					7.93e-07	1.45e-06	1	0
SEL1L2	80343	broad.mit.edu	37	20	13839936	13839936	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr20:13839936A>T	uc010gcf.2	-	18	1872	c.1790T>A	c.(1789-1791)ATG>AAG	p.M597K	SEL1L2_uc002woq.3_Missense_Mutation_p.M458K|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	597	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						GTGTTCATACATATAAGCCAG	0.413		NA											8	31					0	0	0	0
C21orf63	59271	broad.mit.edu	37	21	33876236	33876236	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:33876236G>A	uc002ypr.1	+	7	1270	c.860G>A	c.(859-861)GGT>GAT	p.G287D	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.G284D|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.G192D|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	287	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						CATGAAACAGGTATAAACTTC	0.458		NA											38	92					0	0	0	0
U2AF1	7307	broad.mit.edu	37	21	44521518	44521518	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:44521518G>A	uc002zda.1	-	3	241	c.157C>T	c.(157-159)CGT>TGT	p.R53C	U2AF1_uc002zcy.1_Intron|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Intron|U2AF1_uc010gpi.1_Intron|U2AF1_uc002zdc.1_Missense_Mutation_p.R53C	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	53					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						TGGGGATTACGATAGATGTTT	0.398		NA											79	314					0	0	0	0
AIRE	326	broad.mit.edu	37	21	45709685	45709685	+	Silent	SNP	C	C	T	rs41277550	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:45709685C>T	uc002zei.2	+	6	925	c.798C>T	c.(796-798)CCC>CCT	p.P266P	AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	266	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		GCGCTGCCCCCGTAAGCACCT	0.682		NA							Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				18	34					0	0	0	0
KLHL22	84861	broad.mit.edu	37	22	20800823	20800823	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:20800823C>T	uc002zsl.1	-	6	1555	c.1446G>A	c.(1444-1446)CGG>CGA	p.R482R	KLHL22_uc011ahr.1_Silent_p.R339R	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	482	Kelch 4.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCAGGCGCGCCGCACAGGCC	0.602		NA											19	93					0	0	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39421243	39421243	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:39421243A>C	uc011aoe.1	+	3	433	c.379A>C	c.(379-381)ACC>CCC	p.T127P	APOBEC3D_uc011aod.1_Missense_Mutation_p.T127P|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Missense_Mutation_p.T127P|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	127					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					CCCCAATGTCACCCTGACCAT	0.572		NA											13	80					0	0	0	0
CSDC2	27254	broad.mit.edu	37	22	41969737	41969737	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:41969737C>T	uc003bak.1	+	3	552	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_014460	NP_055275	Q9Y534	CSDC2_HUMAN	RNA-binding protein pippin	85	CSD.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding				0						ATGGCTTCATCACCCCCGAGA	0.607		NA											11	84					0	0	0	0
ABHD5	51099	broad.mit.edu	37	3	43753250	43753250	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:43753250G>C	uc003cmx.2	+	4	666	c.556G>C	c.(556-558)GAC>CAC	p.D186H		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	186					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TGAACGACCAGACCTTGCTGA	0.453		NA											11	54					0	0	0	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438		NA											24	103					0	0	0	0
PLCXD2	257068	broad.mit.edu	37	3	111426919	111426919	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:111426919G>C	uc003dya.2	+	2	896	c.310G>C	c.(310-312)GAA>CAA	p.E104Q	PLCXD2_uc003dyb.2_Missense_Mutation_p.E104Q|PLCXD2_uc003dxz.2_Missense_Mutation_p.E104Q	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	104	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						GACATTTCGAGAACAGCTGGA	0.522		NA											11	83					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124165030	124165030	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:124165030G>T	uc003ehg.2	+	20	3457	c.3330G>T	c.(3328-3330)CAG>CAT	p.Q1110H	KALRN_uc010hrv.1_Missense_Mutation_p.Q1101H|KALRN_uc003ehf.1_Missense_Mutation_p.Q1110H|KALRN_uc011bjy.1_Missense_Mutation_p.Q1101H|KALRN_uc003ehh.1_Missense_Mutation_p.Q456H	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1110					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGCTCCTGCAGAGGGAGAATC	0.577		NA											12	60					2.27e-07	4.18e-07	1	0
ABTB1	80325	broad.mit.edu	37	3	127395886	127395886	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:127395886C>T	uc003ejt.2	+	7	691	c.603C>T	c.(601-603)CTC>CTT	p.L201L	ABTB1_uc003ejr.2_Silent_p.L59L|ABTB1_uc003ejs.2_Silent_p.L176L|ABTB1_uc003eju.2_Silent_p.L59L|ABTB1_uc010hsm.2_5'UTR	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	201						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						GGGACCTGCTCAGCGACCTGG	0.667		NA											12	43					0	0	0	0
ARMC8	25852	broad.mit.edu	37	3	138003316	138003316	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:138003316A>G	uc003esa.1	+	20	2094	c.1727A>G	c.(1726-1728)AAA>AGA	p.K576R	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Missense_Mutation_p.K559R|ARMC8_uc011bmg.1_Missense_Mutation_p.K523R|ARMC8_uc011bmh.1_Missense_Mutation_p.K517R|ARMC8_uc003esb.1_Missense_Mutation_p.K548R|ARMC8_uc003esc.1_Missense_Mutation_p.K348R|ARMC8_uc003esf.1_Missense_Mutation_p.K159R	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	590	ARM 13.						binding				0						ACAACAGCAAAAGATCTTATT	0.443		NA											77	156					0	0	0	0
RBP2	5948	broad.mit.edu	37	3	139173605	139173605	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:139173605C>T	uc003eth.2	-	3	371	c.320G>A	c.(319-321)TGG>TAG	p.W107*		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	107					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	CCACTGCTTCCAGCCGCGGTT	0.532		NA											31	160					0	0	0	0
GFM1	85476	broad.mit.edu	37	3	158363454	158363454	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:158363454G>A	uc003fce.2	+	2	225	c.118G>A	c.(118-120)GTG>ATG	p.V40M	GFM1_uc003fcd.2_Missense_Mutation_p.V40M|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	40					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTCATCAGGGGTGATTCCTAA	0.373		NA											10	49					0	0	0	0
HTR3E	285242	broad.mit.edu	37	3	183824397	183824397	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:183824397C>T	uc010hxq.2	+	9	1753	c.1287C>T	c.(1285-1287)CAC>CAT	p.H429H	HTR3E_uc003fml.3_Silent_p.H414H|HTR3E_uc003fmm.2_Silent_p.H444H|HTR3E_uc010hxr.2_Silent_p.H455H|HTR3E_uc003fmn.2_Silent_p.H429H	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	429	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGTTCAGCCACGCGATGGACG	0.607		NA											22	97					0	0	0	0
KIAA0226	9711	broad.mit.edu	37	3	197427812	197427812	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:197427812C>G	uc003fyc.2	-	7	1116	c.933G>C	c.(931-933)CAG>CAC	p.Q311H	KIAA0226_uc003fyd.3_Missense_Mutation_p.Q251H|KIAA0226_uc003fye.1_Missense_Mutation_p.Q18H|KIAA0226_uc003fyf.2_Missense_Mutation_p.Q144H|KIAA0226_uc003fyg.2_Missense_Mutation_p.Q304H	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	311	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GGGAATCATTCTGGCTGCTGA	0.577		NA											9	61					0	0	0	0
ADD1	118	broad.mit.edu	37	4	2877732	2877732	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:2877732G>C	uc003gfr.2	+	2	278	c.90G>C	c.(88-90)GAG>GAC	p.E30D	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.E30D|ADD1_uc003gfo.2_Missense_Mutation_p.E30D|ADD1_uc003gfp.2_Missense_Mutation_p.E30D|ADD1_uc003gfq.2_Missense_Mutation_p.E30D|ADD1_uc003gfs.2_Missense_Mutation_p.E30D|ADD1_uc003gft.3_Missense_Mutation_p.E30D	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	30					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAGTAGATGAGAACAACCCAG	0.517		NA											27	98					0	0	0	0
ABLIM2	84448	broad.mit.edu	37	4	8021358	8021358	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:8021358G>C	uc003gko.2	-	13	1454	c.1311C>G	c.(1309-1311)ATC>ATG	p.I437M	ABLIM2_uc003gkk.2_Missense_Mutation_p.I100M|ABLIM2_uc003gkl.2_Missense_Mutation_p.I164M|ABLIM2_uc003gkj.3_Missense_Mutation_p.I470M|ABLIM2_uc003gkm.3_Intron|ABLIM2_uc003gkp.2_Intron|ABLIM2_uc003gkq.2_Missense_Mutation_p.I437M|ABLIM2_uc003gkr.2_Intron|ABLIM2_uc003gks.3_Intron	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	437					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						GCTGTCTGTAGATAGGGGGTT	0.473		NA											13	55					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20541203	20541203	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:20541203A>G	uc003gpr.1	+	19	2176	c.1972A>G	c.(1972-1974)ACT>GCT	p.T658A	SLIT2_uc003gps.1_Missense_Mutation_p.T650A	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	658					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TTCTTTATCTACTCTGTAAGT	0.289		NA											9	33					0	0	0	0
KCTD8	386617	broad.mit.edu	37	4	44177085	44177085	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:44177085G>A	uc003gwu.2	-	2	1428	c.1144C>T	c.(1144-1146)CAC>TAC	p.H382Y		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	382						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TTAGGTTGGTGAGCTGTTGCC	0.507		NA								HNSCC(17;0.042)			22	140					0	0	0	0
UGT2A1	10941	broad.mit.edu	37	4	70513058	70513058	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:70513058G>A	uc003hem.3	-	1	368	c.305C>T	c.(304-306)TCA>TTA	p.S102L	UGT2A1_uc011caq.1_Missense_Mutation_p.S102L|UGT2A1_uc010ihu.2_Missense_Mutation_p.S102L|UGT2A1_uc010iht.2_Missense_Mutation_p.S102L	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	102	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CCAAATGGTTGAAGGAGATGG	0.413		NA											11	60					0	0	0	0
MMRN1	22915	broad.mit.edu	37	4	90857719	90857719	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:90857719T>C	uc003hst.2	+	6	2959	c.2888T>C	c.(2887-2889)CTA>CCA	p.L963P	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.L705P	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	963					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CAGAAAGGTCTAACAGAATTT	0.378		NA											18	37					0	0	0	0
ALPK1	80216	broad.mit.edu	37	4	113353568	113353568	+	Silent	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:113353568G>C	uc003iap.3	+	11	3144	c.2865G>C	c.(2863-2865)GGG>GGC	p.G955G	ALPK1_uc003ian.3_Silent_p.G955G|ALPK1_uc011cfx.1_Silent_p.G877G|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Silent_p.G783G	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	955	Ser-rich.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ATTCCAGTGGGAGTTCTTGGG	0.512		NA											13	68					0	0	0	0
QRFPR	84109	broad.mit.edu	37	4	122257976	122257976	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:122257976C>T	uc010inj.1	-	3	926	c.547G>A	c.(547-549)GTG>ATG	p.V183M	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.V183M	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	183	Helical; Name=4; (Potential).					plasma membrane	neuropeptide Y receptor activity				0						AGTTGTTGCACGTGCCACATG	0.423		NA											97	223					0	0	0	0
HSPA4L	22824	broad.mit.edu	37	4	128753927	128753927	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:128753927C>G	uc003ifm.2	+	19	2671	c.2418C>G	c.(2416-2418)CAC>CAG	p.H806Q	HSPA4L_uc011cgr.1_Missense_Mutation_p.H773Q	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	806				H -> R (in Ref. 1; BAA75063).	protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						ATAGTGAACACAATGGCCCAA	0.408		NA											12	61					0	0	0	0
LRBA	987	broad.mit.edu	37	4	151388836	151388836	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:151388836C>T	uc010ipj.2	-	45	7276	c.6802G>A	c.(6802-6804)GAT>AAT	p.D2268N	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Missense_Mutation_p.D158N|LRBA_uc003ilt.3_Missense_Mutation_p.D916N|LRBA_uc003ilu.3_Missense_Mutation_p.D2257N	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2268	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTGGACAAATCTCTGAAGTTG	0.313		NA											8	54					0	0	0	0
PALLD	23022	broad.mit.edu	37	4	169611844	169611844	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:169611844C>T	uc011cjx.1	+	7	1637	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W	PALLD_uc003iru.2_Missense_Mutation_p.R476W|PALLD_uc003irv.2_Missense_Mutation_p.R94W	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	476	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCAGTGGTTTCGGCAAGGGAG	0.527		NA							Pancreatic_Cancer_Familial_Clustering_of				28	131					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897744	175897744	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:175897744G>A	uc003iuc.2	+	5	1738	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	ADAM29_uc003iud.2_Missense_Mutation_p.M356I|ADAM29_uc010irr.2_Missense_Mutation_p.M356I|ADAM29_uc011cki.1_Missense_Mutation_p.M356I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	356	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GATGCATAATGCATGAAGGCA	0.388		NA											19	107					0	0	0	0
CCDC110	256309	broad.mit.edu	37	4	186382220	186382220	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:186382220G>A	uc003ixu.3	-	5	407	c.331C>T	c.(331-333)CGC>TGC	p.R111C	CCDC110_uc003ixv.3_Intron|CCDC110_uc011ckt.1_Missense_Mutation_p.R111C	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	111						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTTCAATGCGCGTGCCAAAC	0.338		NA											20	95					0	0	0	0
SORBS2	8470	broad.mit.edu	37	4	186545017	186545017	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:186545017C>G	uc003iyl.2	-	13	2412	c.1554G>C	c.(1552-1554)CAG>CAC	p.Q518H	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.Q618H|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.Q422H|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.Q632H|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	518						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ATTTGGACTTCTGGATCAGCT	0.562		NA											16	79					0	0	0	0
MTRR	4552	broad.mit.edu	37	5	7885832	7885832	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:7885832C>T	uc003jed.2	+	7	1033	c.1003C>T	c.(1003-1005)CAG>TAG	p.Q335*	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Nonsense_Mutation_p.Q308*|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	335	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CTTTTCCTATCAGCCTGGAGA	0.383		NA											10	84					0	0	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139838838	139838838	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:139838838C>G	uc003lfs.1	+	9	1694	c.1570C>G	c.(1570-1572)CTT>GTT	p.L524V	ANKHD1_uc003lfq.1_Missense_Mutation_p.L524V|ANKHD1_uc003lfr.2_Missense_Mutation_p.L524V|ANKHD1_uc003lft.1_5'UTR|ANKHD1_uc003lfu.1_5'UTR|ANKHD1_uc003lfp.2_Missense_Mutation_p.L513V|ANKHD1_uc003lfo.2_Missense_Mutation_p.L524V|ANKHD1_uc010jfk.2_Missense_Mutation_p.L524V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	524						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGACTTTCTTATTAAGGC	0.443		NA											15	60					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580954	140580954	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140580954G>A	uc003liy.2	+	1	1607	c.1607G>A	c.(1606-1608)CGC>CAC	p.R536H	PCDHB11_uc011daj.1_Missense_Mutation_p.R171H	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	536	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACAGACCGCGGCTCCCCG	0.667		NA											48	88					0	0	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589638	140589638	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140589638G>A	uc003liz.2	+	1	1348	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	PCDHB12_uc011dak.1_Missense_Mutation_p.E50K	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	387	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTATCCCGGAGGACATCCC	0.468		NA											12	45					0	0	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589962	140589962	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140589962G>A	uc003liz.2	+	1	1672	c.1483G>A	c.(1483-1485)GAC>AAC	p.D495N	PCDHB12_uc011dak.1_Missense_Mutation_p.D158N	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	495	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGTCCCAGGACCCGCACCT	0.662		NA											22	159					0	0	0	0
EBF1	1879	broad.mit.edu	37	5	158524010	158524010	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:158524010G>T	uc010jip.2	-	2	565	c.263C>A	c.(262-264)GCG>GAG	p.A88E	EBF1_uc011ddw.1_5'Flank|EBF1_uc011ddx.1_Missense_Mutation_p.A88E|EBF1_uc003lxl.3_Missense_Mutation_p.A88E	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	88					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCACAAACGCTGTCCTCTC	0.637		NA	T	HMGA2	lipoma								12	23					1.62e-10	3.02e-10	1	0
GABRB2	2561	broad.mit.edu	37	5	160973365	160973365	+	Silent	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:160973365C>G	uc003lys.1	-	3	350	c.132G>C	c.(130-132)CTG>CTC	p.L44L	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Silent_p.L44L|GABRB2_uc003lyt.1_Silent_p.L44L|GABRB2_uc010jiu.1_Intron|GABRB2_uc011dei.1_Silent_p.L44L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	44	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CATAGCCTTTCAGGAGTCTAT	0.453		NA											6	35					0	0	0	0
GABRG2	2566	broad.mit.edu	37	5	161531032	161531032	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:161531032G>T	uc003lyz.3	+	6	1127	c.769G>T	c.(769-771)GGA>TGA	p.G257*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.G297*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.G257*|GABRG2_uc011dej.1_Nonsense_Mutation_p.G162*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	257	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GACAACTTCCGGTAAGATGCA	0.383		NA											16	34					2.58e-16	4.94e-16	1	0
DDX41	51428	broad.mit.edu	37	5	176943153	176943153	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:176943153C>A	uc003mho.2	-	4	361	c.340G>T	c.(340-342)GAG>TAG	p.E114*	DDX41_uc003mhm.2_5'Flank|DDX41_uc003mhn.2_5'UTR|DDX41_uc003mhp.2_5'UTR|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	114					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			AGGATCTTCTCTTCTTCCTTC	0.522		NA											39	205					6.46e-13	1.21e-12	1	0
ZFP2	80108	broad.mit.edu	37	5	178358852	178358852	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:178358852C>A	uc003mjn.1	+	5	1047	c.538C>A	c.(538-540)CAC>AAC	p.H180N	ZFP2_uc010jky.2_Missense_Mutation_p.H180N|ZFP2_uc010jkx.1_Missense_Mutation_p.H180N	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	180	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TCAACGAACTCACACCGGAGA	0.398		NA											8	37					1.13e-05	2.03e-05	1	0
EHMT2	10919	broad.mit.edu	37	6	31860266	31860266	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:31860266T>C	uc003nxz.1	-	7	792	c.782A>G	c.(781-783)GAG>GGG	p.E261G	EHMT2_uc003nxy.1_Missense_Mutation_p.E52G|EHMT2_uc011don.1_Missense_Mutation_p.E318G|EHMT2_uc003nya.1_Missense_Mutation_p.E261G	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	261					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGTCTCCCACTCCTCCAGGGA	0.547		NA											15	61					0	0	0	0
PSMB8	5696	broad.mit.edu	37	6	32808747	32808747	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:32808747C>A	uc003oce.2	-	6	863	c.820G>T	c.(820-822)GCC>TCC	p.A274S	TAP2_uc011dqf.1_5'Flank|TAP2_uc003ocb.1_5'Flank|TAP2_uc003occ.2_5'Flank|TAP2_uc003ocd.2_5'Flank|PSMB8_uc003ocf.2_Missense_Mutation_p.A270S	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	274					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						TATTGATTGGCTTCCCGGTAC	0.512		NA											16	46					2.23e-06	4.05e-06	1	0
PHF3	23469	broad.mit.edu	37	6	64423243	64423243	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:64423243G>A	uc003pep.1	+	15	5785	c.5759G>A	c.(5758-5760)CGC>CAC	p.R1920H	PHF3_uc003pen.2_Missense_Mutation_p.R1832H|PHF3_uc011dxs.1_Missense_Mutation_p.R1189H	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1920					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAGGGGACCGCCAGAGATTT	0.418		NA											47	81					0	0	0	0
MANEA	79694	broad.mit.edu	37	6	96052716	96052716	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:96052716T>G	uc003poo.1	+	4	808	c.668T>G	c.(667-669)ATA>AGA	p.I223R		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	223	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACTTTTCACATAGAACCATAT	0.224		NA											3	15					0	0	0	0
FIG4	9896	broad.mit.edu	37	6	110112620	110112620	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:110112620C>T	uc003ptt.2	+	20	2437	c.2222C>T	c.(2221-2223)ACG>ATG	p.T741M	FIG4_uc011eau.1_Missense_Mutation_p.T464M	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	741					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CAGCGGAAAACGGCAGCCAGC	0.507		NA											14	127					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129470160	129470160	+	Missense_Mutation	SNP	G	G	A	rs141340479	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:129470160G>A	uc003qbn.2	+	7	1051	c.946G>A	c.(946-948)GAT>AAT	p.D316N	LAMA2_uc003qbo.2_Missense_Mutation_p.D316N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	316	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CACATGTGGCGATAGCTGTGA	0.428		NA											16	91					0	0	0	0
HOXA1	3198	broad.mit.edu	37	7	27134145	27134145	+	Missense_Mutation	SNP	C	C	T	rs41311760		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:27134145C>T	uc003sye.2	-	2	1016	c.922G>A	c.(922-924)GAG>AAG	p.E308K	HOXA1_uc003syd.2_3'UTR|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	308						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						GAGGATTCCTCGGCCTTCTCG	0.597		NA											11	47					0	0	0	0
TARP	445347	broad.mit.edu	37	7	38305106	38305106	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:38305106C>A	uc003tge.1	-	5	978	c.601G>T	c.(601-603)GAG>TAG	p.E201*	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						GTGTTCCCCTCCTGGGATCCC	0.418		NA											41	143					2.48e-24	4.79e-24	1	0
BLVRA	644	broad.mit.edu	37	7	43843400	43843400	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:43843400G>C	uc003tir.2	+	7	669	c.586G>C	c.(586-588)GAT>CAT	p.D196H	BLVRA_uc010kxv.2_Missense_Mutation_p.D196H	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	196					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	GCGAAAGGAAGATCAGTATAT	0.478		NA											28	145					0	0	0	0
EGFR	1956	broad.mit.edu	37	7	55233026	55233026	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:55233026C>T	uc003tqk.2	+	15	2022	c.1776C>T	c.(1774-1776)GTC>GTT	p.V592V	EGFR_uc003tqi.2_Silent_p.V592V|EGFR_uc003tqj.2_Silent_p.V592V|EGFR_uc010kzg.1_Silent_p.V547V|EGFR_uc011kco.1_Silent_p.V539V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	592	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCCACTGCGTCAAGACCTGCC	0.547		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	607					0	0	0	0
SBDS	51119	broad.mit.edu	37	7	66456261	66456261	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:66456261C>G	uc003tvm.1	-	4	671	c.487G>C	c.(487-489)GAG>CAG	p.E163Q		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	163					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						TTCATTTTCTCTTTTAACTGC	0.368		NA	Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				8	26					0	0	0	0
NSUN5	55695	broad.mit.edu	37	7	72717906	72717906	+	Silent	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:72717906G>A	uc003txw.2	-	8	1098	c.1062C>T	c.(1060-1062)CTC>CTT	p.L354L	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.L354L|NSUN5_uc003txx.2_Silent_p.L316L|NSUN5_uc011kev.1_Silent_p.L354L	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	354							methyltransferase activity				0		Lung NSC(55;0.163)				TGGAGTAGACGAGCCGCTGCA	0.677		NA											7	19					0	0	0	0
HIP1	3092	broad.mit.edu	37	7	75172176	75172176	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:75172176C>A	uc003uds.1	-	28	2925	c.2884G>T	c.(2884-2886)GAG>TAG	p.E962*	HIP1_uc011kfz.1_Nonsense_Mutation_p.E788*	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	962	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CTACCTGTCTCTTCGATCTGT	0.572		NA	T	PDGFRB	CMML								13	49					7.04e-09	1.3e-08	1	0
SLC26A3	1811	broad.mit.edu	37	7	107408304	107408304	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:107408304C>T	uc003ver.2	-	19	2323	c.2112G>A	c.(2110-2112)GTG>GTA	p.V704V	SLC26A3_uc003ves.2_Silent_p.V591V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	704	Helical; (Potential).|STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TTGAGCTTTTCACTTCACCAT	0.328		NA											11	29					0	0	0	0
SLC4A2	6522	broad.mit.edu	37	7	150772740	150772740	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:150772740G>T	uc003wit.3	+	21	3605	c.3349G>T	c.(3349-3351)GTG>TTG	p.V1117L	SLC4A2_uc011kve.1_Missense_Mutation_p.V1108L|SLC4A2_uc003wiu.3_Missense_Mutation_p.V1103L|SLC4A2_uc003wiv.3_Missense_Mutation_p.V311L|uc011kvf.1_Intron	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1117	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCCTGGCCGTGCTCTTTGG	0.607		NA											9	56					5.69e-11	1.06e-10	1	0
MSR1	4481	broad.mit.edu	37	8	16026358	16026358	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:16026358G>A	uc003wwz.2	-	4	437	c.239C>T	c.(238-240)ACG>ATG	p.T80M	MSR1_uc010lsu.2_Missense_Mutation_p.T98M|MSR1_uc003wxa.2_Missense_Mutation_p.T80M|MSR1_uc003wxb.2_Missense_Mutation_p.T80M|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	80	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GCAATTCTTCGTTTCCCACTT	0.338		NA											30	40					0	0	0	0
ABRA	137735	broad.mit.edu	37	8	107782160	107782160	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:107782160C>T	uc003ymm.3	-	1	313	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	87					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CCATGTCCTTCTGGCAGGCGG	0.532		NA											18	124					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110986443	110986443	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:110986443A>T	uc003ynr.3	-	1	517	c.175T>A	c.(175-177)TGC>AGC	p.C59S	KCNV1_uc010mcw.2_Missense_Mutation_p.C59S	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	59	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGCGGGAAGCAGGACAGCGCC	0.711		NA											3	5					0	0	0	0
UNC13B	10497	broad.mit.edu	37	9	35380621	35380621	+	Missense_Mutation	SNP	G	G	A	rs138199360		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:35380621G>A	uc003zwq.2	+	17	2405	c.2113G>A	c.(2113-2115)GTC>ATC	p.V705I	UNC13B_uc003zwr.2_Missense_Mutation_p.V705I	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	705					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CGAGATGGACGTCTGGTACAA	0.493		NA											22	62					0	0	0	0
C9orf3	84909	broad.mit.edu	37	9	97522394	97522394	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:97522394C>T	uc004ava.2	+	1	464	c.329C>T	c.(328-330)TCT>TTT	p.S110F	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.S110F|C9orf3_uc004auy.2_Missense_Mutation_p.S110F|C9orf3_uc004auz.1_Missense_Mutation_p.S110F	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	110					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AAAGATACTTCTGATAAAGAT	0.408		NA											29	97					0	0	0	0
SLC31A1	1317	broad.mit.edu	37	9	116022567	116022567	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:116022567C>T	uc004bgu.2	+	5	573	c.387C>T	c.(385-387)AGC>AGT	p.S129S	FKBP15_uc010muu.1_Intron|SLC31A1_uc004bgv.3_Silent_p.S129S	NM_001859	NP_001850	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporters),	129	Cytoplasmic (Potential).					integral to plasma membrane	copper ion transmembrane transporter activity				0						AGATGCTGAGCTTTCCTCACC	0.498		NA											20	84					0	0	0	0
RAI2	10742	broad.mit.edu	37	X	17819548	17819549	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:17819548_17819549GG>TT	uc004cyf.2	-	3	1152_1153	c.582_583CC>AA	c.(580-585)TCCCAG>TCAAAG	p.Q195K	RAI2_uc004cyg.2_Missense_Mutation_p.Q195K|RAI2_uc010nfa.2_Missense_Mutation_p.Q195K|RAI2_uc004cyh.3_Missense_Mutation_p.Q195K|RAI2_uc011miy.1_Missense_Mutation_p.Q145K	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	195					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					AGAGTGCCCTGGGAGGGAAACA	0.658		NA											9	42					0	0	0	0
CXorf23	256643	broad.mit.edu	37	X	19983783	19983783	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:19983783G>C	uc004czp.2	-	3	653	c.653C>G	c.(652-654)TCA>TGA	p.S218*	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Translation_Start_Site|CXorf23_uc004czo.2_Nonsense_Mutation_p.S168*	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	218						mitochondrion				lung(1)|skin(1)	2						AGGTCTTTTTGATGTGTGTCC	0.438		NA											22	101					0	0	0	0
DMD	1756	broad.mit.edu	37	X	31947740	31947740	+	Silent	SNP	G	G	C			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:31947740G>C	uc004dda.1	-	47	7129	c.6885C>G	c.(6883-6885)CTC>CTG	p.L2295L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L951L|DMD_uc004dcx.2_Silent_p.L954L|DMD_uc004dcz.2_Silent_p.L2172L|DMD_uc004dcy.1_Silent_p.L2291L|DMD_uc004ddb.1_Silent_p.L2287L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2295	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGTCTGCTTGAGCTTATTTT	0.403		NA											16	84					0	0	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479236	55479236	+	Silent	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:55479236A>G	uc004dum.2	+	1	699	c.429A>G	c.(427-429)AGA>AGG	p.R143R		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	143	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTGTGCGCAGAGGGTACCTGA	0.532		NA											18	60					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70347742	70347742	+	Splice_Site	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:70347742G>T	uc004dyy.2	+	22	3181	c.2982_splice	c.e22-1	p.S994_splice	MED12_uc011mpq.1_Splice_Site_p.S994_splice|MED12_uc004dyz.2_Splice_Site_p.S994_splice|MED12_uc004dza.2_Splice_Site_p.S841_splice|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12						androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCCCTGCAGCGACTTTTGC	0.493		NA											11	24					2.81e-09	5.22e-09	1	0
HDAC8	55869	broad.mit.edu	37	X	71681889	71681889	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:71681889C>G	uc004eau.2	-	9	1012	c.970G>C	c.(970-972)GGG>CGG	p.G324R	HDAC8_uc011mqe.1_Missense_Mutation_p.G181R|HDAC8_uc011mqf.1_Missense_Mutation_p.G129R|HDAC8_uc011mqg.1_Missense_Mutation_p.G233R	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	324	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	AGTGTTTTCCCTAGGATGACC	0.463		NA											18	101					0	0	0	0
XKRX	402415	broad.mit.edu	37	X	100183244	100183244	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:100183244G>A	uc004egn.2	-	1	655	c.50C>T	c.(49-51)TCA>TTA	p.S17L	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	17						integral to membrane|plasma membrane				breast(1)	1						CTCCAGAGATGAAACCGGATC	0.468		NA											67	182					0	0	0	0
H2BFWT	158983	broad.mit.edu	37	X	103267977	103267977	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:103267977G>A	uc004elr.2	-	1	280	c.256C>T	c.(256-258)CGC>TGC	p.R86C		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	86					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AGCACCCGGCGGAAATAGGTG	0.622		NA											11	102					0	0	0	0
KIAA1210	57481	broad.mit.edu	37	X	118220797	118220797	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:118220797G>T	uc004era.3	-	11	4396	c.4396C>A	c.(4396-4398)CTA>ATA	p.L1466I		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1466										ovary(4)|skin(1)	5						TGATTGGATAGGTTTGCATGC	0.433		NA											11	80					6.43e-13	1.21e-12	1	0
ENOX2	10495	broad.mit.edu	37	X	129799651	129799651	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:129799651C>T	uc004evw.2	-	10	1485	c.1067G>A	c.(1066-1068)CGG>CAG	p.R356Q	ENOX2_uc004evx.2_Missense_Mutation_p.R327Q|ENOX2_uc004evy.2_Missense_Mutation_p.R327Q|ENOX2_uc004evv.2_Missense_Mutation_p.R183Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	356					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GATGTTCTTCCGCTGGGCTTT	0.483		NA											4	22					0	0	0	0
OR13H1	347468	broad.mit.edu	37	X	130678614	130678614	+	Silent	SNP	T	T	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:130678614T>G	uc011muw.1	+	1	567	c.567T>G	c.(565-567)TCT>TCG	p.S189S	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TGACCTGTTCTGATACCAGCC	0.463		NA											49	246					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135431895	135431895	+	Silent	SNP	C	C	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:135431895C>G	uc004ezu.1	+	6	6321	c.6030C>G	c.(6028-6030)CTC>CTG	p.L2010L	GPR112_uc010nsb.1_Silent_p.L1805L|GPR112_uc010nsc.1_Silent_p.L1777L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2010	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGACATGGCTCTTATCTAGTC	0.453		NA											19	138					0	0	0	0
ZIC3	7547	broad.mit.edu	37	X	136649666	136649666	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:136649666C>T	uc004fak.2	+	1	1321	c.816C>T	c.(814-816)TTC>TTT	p.F272F		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	272	C2H2-type 1; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ACCGGACCTTCAGCACCATGC	0.612		NA											9	94					0	0	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967283	142967283	+	Silent	SNP	A	A	G			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:142967283A>G	uc004fca.2	+	1	111	c.81A>G	c.(79-81)CCA>CCG	p.P27P		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	27							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAGAACCAGATGAAAGCA	0.512		NA											44	111					0	0	0	0
CD99L2	83692	broad.mit.edu	37	X	149963727	149963727	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:149963727G>A	uc004fel.2	-	6	500	c.382C>T	c.(382-384)CGA>TGA	p.R128*	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_Nonsense_Mutation_p.R79*|CD99L2_uc004fen.2_Nonsense_Mutation_p.R56*|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_Intron	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	128	Extracellular (Potential).			R -> Q (in Ref. 4; BAG54124).	cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CGATCATTTCGATCATCCAGG	0.448		NA											32	205					0	0	0	0
FAM3A	60343	broad.mit.edu	37	X	153736911	153736911	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:153736911A>T	uc004fls.1	-	4	446	c.169T>A	c.(169-171)TAC>AAC	p.Y57N	FAM3A_uc004flt.1_Missense_Mutation_p.Y71N|FAM3A_uc011mzp.1_Missense_Mutation_p.Y57N|FAM3A_uc004flu.1_Missense_Mutation_p.Y71N|FAM3A_uc011mzq.1_Missense_Mutation_p.Y57N|FAM3A_uc004flw.1_Missense_Mutation_p.Y57N	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	57						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCACACTTGTACTTCCTGGCC	0.647		NA											6	11					0	0	0	0
MPP1	4354	broad.mit.edu	37	X	154033634	154033634	+	Silent	SNP	C	C	T			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:154033634C>T	uc004fmp.1	-	1	130	c.15G>A	c.(13-15)GCG>GCA	p.A5A	MPP1_uc010nvg.1_Silent_p.A5A|MPP1_uc011mzv.1_5'UTR|MPP1_uc004fmq.1_5'UTR|MPP1_uc011mzw.1_Silent_p.A5A|MPP1_uc010nvh.1_Silent_p.A5A	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	5					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGCCCTCGCTCGCCTTGAGGG	0.672		NA											4	25					0	0	0	0
SYDE2	84144	broad.mit.edu	37	1	85656306	85656307	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:85656306_85656307insA	uc009wcm.2	-	2	923_924	c.874_875insT	c.(874-876)TATfs	p.Y292fs	SYDE2_uc001dku.3_Frame_Shift_Ins_p.Y292fs	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	292					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		AGTACTCTGATATAGCCAATTG	0.381		NA											58	127	---	---	---	---	NA	NA	NA	NA
TANC1	85461	broad.mit.edu	37	2	160085398	160085399	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:160085398_160085399insA	uc002uag.2	+	26	4416_4417	c.4142_4143insA	c.(4141-4143)AGAfs	p.R1381fs	TANC1_uc010zcm.1_Frame_Shift_Ins_p.R1373fs|TANC1_uc010fon.2_Frame_Shift_Ins_p.R225fs	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1381	TPR 3.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AGAGCGAAGAGAAATAGCAGGT	0.47		NA											40	96	---	---	---	---	NA	NA	NA	NA
MAGEA3	4102	broad.mit.edu	37	X	151935346	151935346	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:151935346delC	uc004fgp.2	-	3	1030	c.821delG	c.(820-822)GGTfs	p.G274fs		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	274	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTTGGACCCCACAGGAA	0.532		NA											36	253	---	---	---	---	NA	NA	NA	NA
