Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
VPS13D	55187	broad.mit.edu	37	1	12331121	12331121	+	Silent	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:12331121G>A	uc001atv.2	+	17	2184	c.2043G>A	c.(2041-2043)AAG>AAA	p.K681K	VPS13D_uc001atw.2_Silent_p.K681K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	681					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACAAGCTGAAGATGCAGACCA	0.458		NA											4	52					0	0	0	0
NFYC	4802	broad.mit.edu	37	1	41228713	41228713	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:41228713A>T	uc001cge.2	+	6	723	c.715A>T	c.(715-717)ATC>TTC	p.I239F	NFYC_uc010ojm.1_Missense_Mutation_p.I145F|NFYC_uc001cfx.3_Missense_Mutation_p.I239F|NFYC_uc009vwd.2_Missense_Mutation_p.I239F|NFYC_uc001cfz.2_Missense_Mutation_p.I239F|NFYC_uc010ojn.1_Missense_Mutation_p.I201F|NFYC_uc001cfy.3_Missense_Mutation_p.I239F|NFYC_uc001cgc.2_Missense_Mutation_p.I205F|NFYC_uc001cgb.2_Missense_Mutation_p.I239F|NFYC_uc001cgd.3_Missense_Mutation_p.I239F	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1	239					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			GATCCAGCAGATCCCGGTGAG	0.433		NA											8	11					0	0	0	0
KIAA0467	23334	broad.mit.edu	37	1	43912750	43912750	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:43912750G>A	uc001cjk.1	+	51	6962	c.6500G>A	c.(6499-6501)CGG>CAG	p.R2167Q	KIAA0467_uc001cjl.1_Missense_Mutation_p.R155Q	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3066						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGGTGCTGCGGCACGGCTAC	0.597		NA											3	31					0	0	0	0
ACOT11	26027	broad.mit.edu	37	1	55058224	55058224	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:55058224G>T	uc001cxm.1	+	4	399	c.317G>T	c.(316-318)GGA>GTA	p.G106V	ACOT11_uc001cxj.1_5'UTR|ACOT11_uc001cxk.2_Missense_Mutation_p.G72V|ACOT11_uc001cxl.1_Missense_Mutation_p.G106V	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	106	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CCCAGTGTTGGACAAGTGGTG	0.607		NA											13	53					4.37e-10	5.4e-10	1	0
CCDC18	343099	broad.mit.edu	37	1	93680428	93680428	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:93680428T>A	uc001dpq.2	+	12	2146	c.1978T>A	c.(1978-1980)TTG>ATG	p.L660M	CCDC18_uc009wdl.1_Missense_Mutation_p.L221M	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	541	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAATTCTGATTTGAAGGTTAA	0.378		NA											3	27					0	0	0	0
VPS72	6944	broad.mit.edu	37	1	151149264	151149264	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:151149264C>T	uc001exe.1	-	6	994	c.951G>A	c.(949-951)AAG>AAA	p.K317K	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	317					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CACGAATGATCTTGAAGGCTC	0.597		NA											8	88					0	0	0	0
LINGO4	339398	broad.mit.edu	37	1	151774040	151774040	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:151774040A>G	uc001ezf.1	-	2	1331	c.1141T>C	c.(1141-1143)TCC>CCC	p.S381P		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	381	Extracellular (Potential).|LRRCT.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGGGGGGGACATGCCAAAG	0.622		NA											10	55					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176661264	176661264	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:176661264G>A	uc001gkz.2	+	6	3598	c.2434G>A	c.(2434-2436)GAT>AAT	p.D812N	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	812					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTCCACAGATGATAACTGCAC	0.458		NA									OREG0014001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	76					0	0	0	0
CFHR2	3080	broad.mit.edu	37	1	196918742	196918742	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:196918742C>T	uc001gtq.1	+	2	293	c.216C>T	c.(214-216)TGC>TGT	p.C72C	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	72	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						GCATAACGTGCGCAGAAGAAG	0.408		NA											9	21					0	0	0	0
NFASC	23114	broad.mit.edu	37	1	204978741	204978741	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:204978741T>G	uc001hbj.2	+	28	3674	c.3346T>G	c.(3346-3348)TGC>GGC	p.C1116G	NFASC_uc010pra.1_Missense_Mutation_p.C1050G|NFASC_uc001hbi.2_Missense_Mutation_p.C1045G|NFASC_uc010prb.1_Missense_Mutation_p.C1065G|NFASC_uc010prc.1_Missense_Mutation_p.C616G|NFASC_uc001hbl.1_Missense_Mutation_p.C192G|NFASC_uc001hbm.1_Missense_Mutation_p.C139G|NFASC_uc009xbh.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1223	Helical; (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGGCTTATGTGCGCCATCGC	0.592		NA											7	49					0	0	0	0
VASH2	79805	broad.mit.edu	37	1	213147325	213147325	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:213147325C>T	uc001hjy.2	+	6	1112	c.908C>T	c.(907-909)CCG>CTG	p.P303L	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.P238L|VASH2_uc010ptn.1_Missense_Mutation_p.P199L|VASH2_uc001hjw.2_Missense_Mutation_p.P259L	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	303					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		GCCCACTCTCCGACCCAAGTG	0.567		NA											4	58					0	0	0	0
DISP1	84976	broad.mit.edu	37	1	223178539	223178539	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:223178539T>C	uc001hnu.1	+	8	3947	c.3800T>C	c.(3799-3801)CTG>CCG	p.L1267P		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1267					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTCTTCTCTCTGAATCAGAGA	0.517		NA											3	149					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228467143	228467143	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:228467143C>T	uc009xez.1	+	27	7438	c.7394C>T	c.(7393-7395)TCA>TTA	p.S2465L	OBSCN_uc001hsn.2_Missense_Mutation_p.S2465L|OBSCN_uc001hsp.1_Missense_Mutation_p.S164L|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2465					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGGTGGTCTCAGGTGAGCAC	0.682		NA											4	38					0	0	0	0
ZNF22	7570	broad.mit.edu	37	10	45498926	45498926	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:45498926T>C	uc001jbw.2	+	2	353	c.110T>C	c.(109-111)ATT>ACT	p.I37T	C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894	P17026	ZNF22_HUMAN	zinc finger protein 22 (KOX 15)	37					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)				GGCATGACTATTCGATTTGAC	0.463		NA											14	52					0	0	0	0
DYDC2	84332	broad.mit.edu	37	10	82126492	82126492	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:82126492G>A	uc001kca.1	+	5	699	c.319G>A	c.(319-321)GAG>AAG	p.E107K	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Missense_Mutation_p.E107K	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	107							protein binding				0			Colorectal(32;0.229)			ATTCATGCAGGAGGACACAAA	0.438		NA											33	115					0	0	0	0
HELLS	3070	broad.mit.edu	37	10	96350210	96350210	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:96350210G>T	uc001kjt.2	+	14	1634	c.1529G>T	c.(1528-1530)CGA>CTA	p.R510L	HELLS_uc001kjs.2_Missense_Mutation_p.R494L|HELLS_uc009xul.2_Missense_Mutation_p.R412L|HELLS_uc009xum.2_Missense_Mutation_p.R380L|HELLS_uc009xun.2_Missense_Mutation_p.R386L|HELLS_uc009xuo.2_Missense_Mutation_p.R556L|HELLS_uc001kju.2_Missense_Mutation_p.R149L|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Missense_Mutation_p.R372L|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	510					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		CGACCAAAACGACGAACTAGA	0.343		NA											12	46					2.27e-07	2.69e-07	1	0
PTPRE	5791	broad.mit.edu	37	10	129839235	129839235	+	Silent	SNP	C	C	T	rs144835853		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:129839235C>T	uc001lkb.2	+	3	369	c.90C>T	c.(88-90)AAC>AAT	p.N30N	PTPRE_uc009yat.2_Silent_p.N41N|PTPRE_uc010qup.1_RNA|PTPRE_uc009yau.2_Silent_p.N30N|PTPRE_uc001lkc.1_RNA	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	30	Extracellular (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CCGACAGCAACGAGACAACCA	0.607		NA											4	23					0	0	0	0
LGR4	55366	broad.mit.edu	37	11	27395209	27395209	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:27395209T>A	uc001mrj.3	-	15	1753	c.1268A>T	c.(1267-1269)AAT>ATT	p.N423I	LGR4_uc001mrk.3_Missense_Mutation_p.N399I	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	423	LRR 15.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AGTTAATTCATTGAAACTTAC	0.333		NA											18	25					0	0	0	0
OR4D10	390197	broad.mit.edu	37	11	59245249	59245249	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:59245249C>T	uc001nnz.1	+	1	347	c.347C>T	c.(346-348)TCG>TTG	p.S116L		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTTTCTCTTTCGGTGATGGCA	0.478		NA											25	68					0	0	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275560	130275560	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:130275560G>A	uc001qgg.3	-	9	2921	c.2563C>T	c.(2563-2565)CGA>TGA	p.R855*	ADAMTS8_uc001qgf.2_Nonsense_Mutation_p.R336*	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	855	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCTACAGTTCGCCTCTGCCAG	0.652		NA											5	86					0	0	0	0
SRGAP1	57522	broad.mit.edu	37	12	64456755	64456755	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:64456755C>G	uc010ssp.1	+	7	916	c.860C>G	c.(859-861)GCG>GGG	p.A287G	SRGAP1_uc001srt.2_Missense_Mutation_p.A287G|SRGAP1_uc001srv.2_Missense_Mutation_p.A247G	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	287					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TATCTGTCTGCGGAGTACAAC	0.373		NA											7	30					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109696115	109696115	+	Silent	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:109696115G>T	uc001tob.2	+	46	6425	c.6306G>T	c.(6304-6306)CGG>CGT	p.R2102R	ACACB_uc001toc.2_Silent_p.R2102R|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.R768R	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2102	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGGAGACACGGACTGTGGAGG	0.632		NA											9	32					2.18e-05	2.5e-05	1	0
MED13L	23389	broad.mit.edu	37	12	116408480	116408480	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:116408480T>C	uc001tvw.2	-	27	6041	c.5986A>G	c.(5986-5988)ATC>GTC	p.I1996V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1996					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AACACCAAGATGTGTGTACAA	0.478		NA											11	47					0	0	0	0
SPATA13	221178	broad.mit.edu	37	13	24876816	24876816	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr13:24876816G>A	uc001upg.1	+	12	2271	c.1864G>A	c.(1864-1866)GTC>ATC	p.V622I	SPATA13_uc001upd.1_Missense_Mutation_p.V1247I|C1QTNF9_uc001upe.2_Intron|SPATA13_uc010tcy.1_Missense_Mutation_p.R569H|SPATA13_uc010tcz.1_Missense_Mutation_p.V506I|SPATA13_uc010tda.1_Missense_Mutation_p.V566I|SPATA13_uc001uph.2_Missense_Mutation_p.V544I|SPATA13_uc010tdb.1_Missense_Mutation_p.V482I|SPATA13_uc009zzz.1_Missense_Mutation_p.R179H	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	622	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GCCCACAAGCGTCCCCCAGCA	0.622		NA											29	102					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99449739	99449739	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr13:99449739T>C	uc001vnt.2	-	53	6021	c.5966A>G	c.(5965-5967)AAT>AGT	p.N1989S	DOCK9_uc001vnw.2_Missense_Mutation_p.N1988S|DOCK9_uc001vnq.2_Missense_Mutation_p.N536S|DOCK9_uc001vnr.2_Missense_Mutation_p.N618S|DOCK9_uc010tin.1_Missense_Mutation_p.N607S|DOCK9_uc001vns.2_Missense_Mutation_p.N524S|DOCK9_uc010tio.1_Missense_Mutation_p.N644S|DOCK9_uc010tip.1_Missense_Mutation_p.N685S	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1989	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGGCCAGCATTGACCTAGAC	0.428		NA											4	18					0	0	0	0
MNAT1	4331	broad.mit.edu	37	14	61201602	61201602	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr14:61201602C>T	uc001xfd.2	+	1	133	c.22C>T	c.(22-24)CGG>TGG	p.R8W	MNAT1_uc010apq.1_Missense_Mutation_p.R8W|MNAT1_uc001xfe.2_Missense_Mutation_p.R8W	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	8	RING-type.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		GGGTTGCCCTCGGTGTAAGAC	0.592		NA						Direct_reversal_of_damage|NER					6	65					0	0	0	0
EIF2B2	8892	broad.mit.edu	37	14	75469994	75469994	+	Silent	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr14:75469994G>T	uc001xrc.1	+	2	262	c.180G>T	c.(178-180)CTG>CTT	p.L60L		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	60					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		TGATGGAGCTGATCCGCAGAG	0.582		NA											8	23					1.07e-07	1.28e-07	1	0
LCMT2	9836	broad.mit.edu	37	15	43622318	43622318	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:43622318C>G	uc001zrg.2	-	1	574	c.370G>C	c.(370-372)GAA>CAA	p.E124Q	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	124					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCAATCCTTTCTGCTTTGCGC	0.627		NA											3	99					0	0	0	0
MTHFS	10588	broad.mit.edu	37	15	80181637	80181637	+	Silent	SNP	T	T	C	rs142942013		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:80181637T>C	uc002bex.3	-	2	217	c.177A>G	c.(175-177)CAA>CAG	p.Q59Q		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	59					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		CAATTTCATCTTGCATGCTCA	0.398		NA											12	61					0	0	0	0
C15orf42	90381	broad.mit.edu	37	15	90168446	90168446	+	Silent	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:90168446C>A	uc002boe.2	+	20	4905	c.4905C>A	c.(4903-4905)GGC>GGA	p.G1635G	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1635					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GCACACCTGGCAAGAGCAGGG	0.612		NA											8	54					0.000274275	0.00030856	1	0
PTX4	390667	broad.mit.edu	37	16	1537325	1537325	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:1537325G>C	uc010uvf.1	-	2	773	c.773C>G	c.(772-774)CCA>CGA	p.P258R		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	263						extracellular region	metal ion binding				0						ACTCTCTCCTGGCACCTGGGG	0.587		NA											9	45					0	0	0	0
AARS	16	broad.mit.edu	37	16	70295032	70295032	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:70295032T>C	uc002eyn.1	-	13	1810	c.1700A>G	c.(1699-1701)CAG>CGG	p.Q567R	AARS_uc010vlu.1_Missense_Mutation_p.Q397R	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	567					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	TCCTCGGACCTGAGCATTCTT	0.398		NA											3	70					0	0	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77325275	77325275	+	Missense_Mutation	SNP	C	C	T	rs150975249	byFrequency	TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:77325275C>T	uc002ffc.3	-	21	3709	c.3290G>A	c.(3289-3291)CGT>CAT	p.R1097H		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1097	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTTAATATTACGGCATCTTCG	0.502		NA											23	234					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	33					0	0	0	0
TMEM104	54868	broad.mit.edu	37	17	72791738	72791738	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr17:72791738C>T	uc002jls.3	+	8	765	c.603C>T	c.(601-603)CCC>CCT	p.P201P	TMEM104_uc010wrf.1_Silent_p.P201P|TMEM104_uc010wrg.1_Silent_p.P214P|TMEM104_uc010dfx.2_Silent_p.P201P	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	201	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)					GCTGGGGGCCCCTGCGCCGAG	0.607		NA											9	30					0	0	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6264018	6264018	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr18:6264018C>A	uc002kmz.3	-	5	307	c.147G>T	c.(145-147)CAG>CAT	p.Q49H	L3MBTL4_uc010dkt.2_Missense_Mutation_p.Q49H	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	49					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				ACCATGCTCCCTGTGCAGCCG	0.423		NA											8	81					0.00448238	0.00491969	1	0
ALPK2	115701	broad.mit.edu	37	18	56171233	56171233	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr18:56171233C>T	uc002lhj.3	-	11	6391	c.6177G>A	c.(6175-6177)CAG>CAA	p.Q2059Q		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	2059	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGCAACATTTCTGACCAGCTT	0.488		NA											8	116					0	0	0	0
FZR1	51343	broad.mit.edu	37	19	3526259	3526259	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:3526259G>A	uc010dtk.2	+	4	296	c.262G>A	c.(262-264)GGC>AGC	p.G88S	FZR1_uc002lxt.2_Missense_Mutation_p.G88S|FZR1_uc002lxv.2_Missense_Mutation_p.G88S	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	88					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCGCAGACGGCCTGGCCTA	0.677		NA											6	19					0	0	0	0
NCR1	9437	broad.mit.edu	37	19	55421380	55421380	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:55421380G>A	uc002qib.2	+	5	675	c.637G>A	c.(637-639)GAC>AAC	p.D213N	NCR1_uc002qic.2_Missense_Mutation_p.D213N|NCR1_uc002qie.2_Missense_Mutation_p.D213N|NCR1_uc002qid.2_Missense_Mutation_p.D118N|NCR1_uc002qif.2_Missense_Mutation_p.D118N|NCR1_uc010esj.2_Missense_Mutation_p.D106N	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	213	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TTTTCCAGGCGACATTGAGAA	0.398		NA											4	144					0	0	0	0
ZNF324	25799	broad.mit.edu	37	19	58983227	58983227	+	Silent	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:58983227G>A	uc002qsw.1	+	4	1462	c.1368G>A	c.(1366-1368)GTG>GTA	p.V456V	ZNF324_uc002qsx.1_Silent_p.V233V	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	456	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCCGCTGCGTGGACTGTGGCA	0.692		NA											21	66					0	0	0	0
SLC30A3	7781	broad.mit.edu	37	2	27480853	27480853	+	Silent	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:27480853G>T	uc002rjk.2	-	4	684	c.498C>A	c.(496-498)GTC>GTA	p.V166V	SLC30A3_uc002rjj.2_5'UTR|SLC30A3_uc010ylh.1_Silent_p.V161V	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	166	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGCAGGCGGACGAAGGCCA	0.627		NA											13	42					1.62e-10	2.01e-10	1	0
SLC30A6	55676	broad.mit.edu	37	2	32422829	32422829	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:32422829C>A	uc002roe.1	+	10	636	c.599C>A	c.(598-600)CCA>CAA	p.P200Q	SLC30A6_uc002rof.1_Missense_Mutation_p.P240Q|SLC30A6_uc010ymw.1_Missense_Mutation_p.P171Q|SLC30A6_uc010ezr.1_Missense_Mutation_p.P200Q|SLC30A6_uc002rog.1_Missense_Mutation_p.P3Q|SLC30A6_uc010ezs.1_Missense_Mutation_p.P126Q|SLC30A6_uc002roh.1_Missense_Mutation_p.P3Q	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	200	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CGAATGAATCCATTTGTTTTG	0.338		NA											23	77					1.38e-19	1.75e-19	1	0
BCL11A	53335	broad.mit.edu	37	2	60688312	60688312	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:60688312C>T	uc002sae.1	-	4	1963	c.1735G>A	c.(1735-1737)GAG>AAG	p.E579K	BCL11A_uc002sab.2_Missense_Mutation_p.E579K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E248K|BCL11A_uc010ypj.1_Missense_Mutation_p.E545K|BCL11A_uc002sad.1_Missense_Mutation_p.E427K|BCL11A_uc002saf.1_Missense_Mutation_p.E545K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	579					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CTGTGGCCCTCGGCCTCGGCC	0.667		NA	T	IGH@	B-CLL								5	39					0	0	0	0
GPAT2	150763	broad.mit.edu	37	2	96689170	96689170	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:96689170C>A	uc002svf.2	-	18	2138	c.1915G>T	c.(1915-1917)GCC>TCC	p.A639S	GPAT2_uc002svd.2_Missense_Mutation_p.A458S|GPAT2_uc002sve.2_Missense_Mutation_p.A441S|GPAT2_uc002svg.2_Missense_Mutation_p.A518S|GPAT2_uc010yuh.1_Missense_Mutation_p.A568S|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	639					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GTGTCACAGGCTGGCCGGGAG	0.587		NA											5	47					3.6e-05	4.11e-05	1	0
NMS	129521	broad.mit.edu	37	2	101096979	101096979	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:101096979G>T	uc002tan.1	+	7	365	c.358G>T	c.(358-360)GAC>TAC	p.D120Y		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	120					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TGCTGCAGTGGACTTCACCAA	0.557		NA											11	48					2.63e-14	3.32e-14	1	0
NEB	4703	broad.mit.edu	37	2	152534283	152534283	+	Silent	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:152534283G>A	uc010fnx.2	-	34	3761	c.3570C>T	c.(3568-3570)AAC>AAT	p.N1190N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1190	Nebulin 29.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTTGTAGACGTTCTACAGCA	0.463		NA											43	166					0	0	0	0
PLA2R1	22925	broad.mit.edu	37	2	160825846	160825846	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:160825846T>C	uc002ube.1	-	19	2892	c.2685A>G	c.(2683-2685)ATA>ATG	p.I895M	PLA2R1_uc010zcp.1_Missense_Mutation_p.I895M|PLA2R1_uc002ubf.2_Missense_Mutation_p.I895M	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	895	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						AGTTCTGGTATATCACTGGTG	0.393		NA											8	41					0	0	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545236	234545236	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:234545236C>T	uc002vur.2	+	1	114	c.68C>T	c.(67-69)GCC>GTC	p.A23V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.A23V	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	23				MARAGWTSPVPLCVCLLLTCGFA -> MAPRRVDQPRSFMC VSTADLWLC (in Ref. 1).	flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGTGGCTTTGCCGAGGCAGGG	0.592		NA											4	101					0	0	0	0
MAVS	57506	broad.mit.edu	37	20	3845265	3845265	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr20:3845265T>C	uc002wjw.3	+	6	1157	c.988T>C	c.(988-990)TCA>CCA	p.S330P	MAVS_uc002wjx.3_Missense_Mutation_p.S189P|MAVS_uc002wjy.3_Missense_Mutation_p.S28P	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	330	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GCCAACTAGCTCAAAGCCCCC	0.552		NA											4	113					0	0	0	0
BMP2	650	broad.mit.edu	37	20	6758934	6758934	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr20:6758934G>T	uc002wmu.1	+	3	1174	c.389G>T	c.(388-390)CGG>CTG	p.R130L		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	130					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	AAAACAACCCGGAGATTCTTC	0.393		NA											5	41					1.02e-07	1.24e-07	1	0
ADRBK2	157	broad.mit.edu	37	22	26114347	26114347	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr22:26114347G>A	uc003abx.3	+	19	1937	c.1790G>A	c.(1789-1791)CGG>CAG	p.R597Q	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	597	PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GGAGAGTCCCGGGTAAGTCTA	0.453		NA											13	72					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49688471	49688471	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr3:49688471G>A	uc003cxe.3	+	4	2059	c.1945G>A	c.(1945-1947)GTC>ATC	p.V649I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	649					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CACCCCTGTCGTCAAGGCTGT	0.592		NA											9	55					0	0	0	0
UGT2B10	7365	broad.mit.edu	37	4	69885860	69885860	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:69885860C>G	uc011cao.1	-	2	245	c.109G>C	c.(109-111)GAA>CAA	p.E37Q	UGT2B10_uc011can.1_Missense_Mutation_p.E37Q			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	74					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GGATAAACTTCGAGTTTAAGA	0.358		NA											22	55					0	0	0	0
EMCN	51705	broad.mit.edu	37	4	101386581	101386581	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:101386581C>A	uc003hvr.2	-	4	554	c.375G>T	c.(373-375)AAG>AAT	p.K125N	EMCN_uc011cel.1_Missense_Mutation_p.K125N|EMCN_uc011cem.1_Missense_Mutation_p.K125N	NM_016242	NP_057326	Q9ULC0	MUCEN_HUMAN	endomucin isoform 1	125	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		CATACTTACTCTTGGGTTTGG	0.373		NA											16	48					4.75e-09	5.85e-09	1	0
TBCK	93627	broad.mit.edu	37	4	107170083	107170083	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:107170083T>C	uc010ilv.2	-	8	1080	c.715A>G	c.(715-717)ATA>GTA	p.I239V	TBCK_uc003hyb.2_5'Flank|TBCK_uc003hye.2_Missense_Mutation_p.I200V|TBCK_uc003hyc.2_Missense_Mutation_p.I176V|TBCK_uc003hyd.2_Missense_Mutation_p.I67V|TBCK_uc003hyf.2_Missense_Mutation_p.I239V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	239	Protein kinase.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CAAACCTTTATAATGTCCAAA	0.179		NA											7	19					0	0	0	0
CDH18	1016	broad.mit.edu	37	5	19721469	19721469	+	Silent	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:19721469G>A	uc003jgc.2	-	4	1007	c.630C>T	c.(628-630)GTC>GTT	p.V210V	CDH18_uc003jgd.2_Silent_p.V210V|CDH18_uc011cnm.1_Silent_p.V210V	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	210	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTTTAGGGTCGACGGAGAAGT	0.453		NA											22	70					0	0	0	0
PDE4D	5144	broad.mit.edu	37	5	58270507	58270507	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:58270507C>T	uc003jsa.2	-	15	2586	c.2414G>A	c.(2413-2415)CGT>CAT	p.R805H	PDE4D_uc003jrx.2_Missense_Mutation_p.R669H|PDE4D_uc003jry.2_Missense_Mutation_p.R503H|PDE4D_uc003jrz.2_Missense_Mutation_p.R741H|PDE4D_uc003jsb.2_Missense_Mutation_p.R744H|PDE4D_uc003jrt.2_Missense_Mutation_p.R503H|PDE4D_uc003jru.2_Missense_Mutation_p.R581H|PDE4D_uc003jrv.2_Missense_Mutation_p.R675H|PDE4D_uc003jrw.2_Missense_Mutation_p.R683H|PDE4D_uc003jrs.2_Missense_Mutation_p.R514H	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	805					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GTCAGGAGAACGATCATCTAT	0.433		NA											29	140					0	0	0	0
CARTPT	9607	broad.mit.edu	37	5	71016344	71016344	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:71016344G>A	uc003kbv.1	+	3	380	c.253G>A	c.(253-255)GGT>AGT	p.G85S		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	85					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	GTGTGACGCCGGTGAGCAGTG	0.507		NA											6	8					0	0	0	0
PCDH12	51294	broad.mit.edu	37	5	141334957	141334957	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:141334957C>T	uc003llx.2	-	1	3671	c.2460G>A	c.(2458-2460)CCG>CCA	p.P820P		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	820	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACAGGGTCGGGGTGAGGT	0.612		NA											12	34					0	0	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41753268	41753268	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:41753268C>T	uc011duf.1	+	6	820	c.572C>T	c.(571-573)GCT>GTT	p.A191V	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	151	LIM zinc-binding 2.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCTGCCCGGCTTGTGACCAG	0.602		NA											4	28					0	0	0	0
C6orf170	221322	broad.mit.edu	37	6	121401926	121401926	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:121401926C>G	uc003pyo.1	-	32	3833	c.3765G>C	c.(3763-3765)CAG>CAC	p.Q1255H		NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	1255					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		TCTATGTGCTCTGCAGTCTAA	0.378		NA											6	41					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155450592	155450592	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:155450592G>A	uc003qqb.2	+	6	1508	c.235G>A	c.(235-237)GGT>AGT	p.G79S	TIAM2_uc003qqe.2_Missense_Mutation_p.G79S	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	79					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ATCGAGACTCGGTGGCCCCAC	0.562		NA											8	33					0	0	0	0
NOD1	10392	broad.mit.edu	37	7	30485828	30485828	+	Silent	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:30485828G>A	uc003tav.2	-	9	2905	c.2382C>T	c.(2380-2382)AAC>AAT	p.N794N		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	794	LRR 5.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TTGTTATTTTGTTTTTTCCCA	0.522		NA											13	147					0	0	0	0
CCDC132	55610	broad.mit.edu	37	7	92987685	92987685	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:92987685C>T	uc003umo.2	+	28	2960	c.2832C>T	c.(2830-2832)ATC>ATT	p.I944I	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Silent_p.I914I|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Silent_p.I664I	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	944											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GATCCCATATCAATAAGAAAG	0.383		NA											7	53					0	0	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829390	146829390	+	Silent	SNP	C	C	T	rs78543192	byFrequency	TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:146829390C>T	uc003weu.1	+	8	1653	c.1137C>T	c.(1135-1137)AAC>AAT	p.N379N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	379	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCTTTTTCAACGCTACAAGTT	0.458		NA								HNSCC(39;0.1)			12	89					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2796121	2796121	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:2796121A>G	uc011kwk.1	-	70	11074	c.10684T>C	c.(10684-10686)TGT>CGT	p.C3562R	CSMD1_uc011kwj.1_Missense_Mutation_p.C2876R|CSMD1_uc010lrg.2_Missense_Mutation_p.C1453R	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3562	Cytoplasmic (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACCACTGTACAGACTGTGTTC	0.468		NA											5	19					0	0	0	0
SGK223	157285	broad.mit.edu	37	8	8185602	8185602	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:8185602G>A	uc003wsh.3	-	4	2690	c.2690C>T	c.(2689-2691)GCG>GTG	p.A897V		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	897							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCTGTTGCCCGCCAGCCCTGC	0.662		NA											31	139					0	0	0	0
FAM150A	389658	broad.mit.edu	37	8	53452412	53452412	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:53452412T>C	uc003xrd.2	-	3	509	c.304A>G	c.(304-306)AGG>GGG	p.R102G	FAM150A_uc011ldt.1_Missense_Mutation_p.R102G	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	102						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				GAGCACTCCCTGGTATTGTAA	0.373		NA											3	51					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144997709	144997709	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:144997709G>C	uc003zaf.1	-	31	6969	c.6799C>G	c.(6799-6801)CAG>GAG	p.Q2267E	PLEC_uc003zab.1_Missense_Mutation_p.Q2130E|PLEC_uc003zac.1_Missense_Mutation_p.Q2134E|PLEC_uc003zad.2_Missense_Mutation_p.Q2130E|PLEC_uc003zae.1_Missense_Mutation_p.Q2098E|PLEC_uc003zag.1_Missense_Mutation_p.Q2108E|PLEC_uc003zah.2_Missense_Mutation_p.Q2116E|PLEC_uc003zaj.2_Missense_Mutation_p.Q2157E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2267	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTGTGCCTGAGCCCGGGCC	0.746		NA											3	25					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21974684	21974684	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:21974684G>A	uc003zpk.2	-	1	355	c.143C>T	c.(142-144)CCG>CTG	p.P48L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.P48L|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	48	ANK 2.		P -> L (in CMM2 and a head and neck tumor; somatic mutation).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.P48L(9)|p.P48P(1)|p.P48R(1)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CACCTGGATCGGCCTCCGACC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			53	141					0	0	0	0
LINGO2	158038	broad.mit.edu	37	9	27949442	27949442	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:27949442G>T	uc003zqu.1	-	2	1422	c.1228C>A	c.(1228-1230)CCC>ACC	p.P410T	LINGO2_uc010mjf.1_Missense_Mutation_p.P410T|LINGO2_uc003zqv.1_Missense_Mutation_p.P410T	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	410	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGATTTTGGGTTTTTTGCAG	0.488		NA											12	50					3.07e-06	3.58e-06	1	0
PHF2	5253	broad.mit.edu	37	9	96418259	96418259	+	Silent	SNP	C	C	T			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:96418259C>T	uc004aub.2	+	8	1143	c.996C>T	c.(994-996)TTC>TTT	p.F332F	PHF2_uc011lug.1_Silent_p.F215F	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	332	JmjC.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GCCTGGCCTTCGCGGGACATT	0.637		NA											3	16					0	0	0	0
SLC44A1	23446	broad.mit.edu	37	9	108097866	108097866	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:108097866T>C	uc004bcn.2	+	4	513	c.292T>C	c.(292-294)TGC>CGC	p.C98R	SLC44A1_uc010mtk.1_Missense_Mutation_p.C98R	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	98	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TTTGGATCCATGCAACCTGGA	0.403		NA											9	81					0	0	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913257	77913257	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chrX:77913257C>A	uc004edc.1	-	2	957	c.661G>T	c.(661-663)GCT>TCT	p.A221S		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	221							nucleic acid binding|zinc ion binding			ovary(1)	1						AACTCTGAAGCTGCTGATGTC	0.517		NA											5	26					0.000602214	0.000674121	1	0
FMR1NB	158521	broad.mit.edu	37	X	147084786	147084786	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chrX:147084786T>A	uc004fcm.2	+	2	417	c.343T>A	c.(343-345)TCT>ACT	p.S115T		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	115	Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCATGGCCAATCTCTGGAAGA	0.363		NA											23	40					0	0	0	0
FAM118B	79607	broad.mit.edu	37	11	126126642	126126642	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:126126642delA	uc001qdf.2	+	7	1060	c.877delA	c.(877-879)ATGfs	p.M293fs	FAM118B_uc009zca.2_Frame_Shift_Del_p.M297fs|FAM118B_uc001qdg.2_Frame_Shift_Del_p.M293fs	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	293											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TCGAGAAAACATGCTGGACAA	0.453		NA											32	140	---	---	---	---	NA	NA	NA	NA
HTT	3064	broad.mit.edu	37	4	3156043	3156043	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:3156043delC	uc011bvq.1	+	28	3673	c.3528delC	c.(3526-3528)AACfs	p.N1176fs		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1174					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CTCTAACAAACCCCCCTTCTC	0.383		NA											5	9	---	---	---	---	NA	NA	NA	NA
