Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1573143	1573143	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:1573143G>T	uc001agv.1	-	17	1556	c.1445C>A	c.(1444-1446)CCC>CAC	p.P482H	CDK11B_uc009vkj.2_Missense_Mutation_p.P139H|CDK11B_uc001ags.1_Missense_Mutation_p.P340H|CDK11B_uc001agt.1_Missense_Mutation_p.P265H|CDK11B_uc001aha.1_Missense_Mutation_p.P448H|CDK11B_uc001agw.1_Missense_Mutation_p.P437H|CDK11B_uc001agy.1_Missense_Mutation_p.P480H|CDK11B_uc001agx.1_Missense_Mutation_p.P471H|CDK11B_uc001agz.1_Missense_Mutation_p.P226H	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	495	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						GACGATGTTGGGATGCTGGGC	0.607		NA											21	222					1.28e-07	4.09e-07	1	0
ARHGEF16	27237	broad.mit.edu	37	1	3397090	3397090	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:3397090G>A	uc001akg.3	+	15	2317	c.2069G>A	c.(2068-2070)CGT>CAT	p.R690H	ARHGEF16_uc001aki.2_Missense_Mutation_p.R402H|ARHGEF16_uc001akj.2_Missense_Mutation_p.R402H|ARHGEF16_uc010nzh.1_Missense_Mutation_p.R394H	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	690					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ATCACCAGCCGTGTGGCCGTG	0.677		NA											6	49					0	0	0	0
MAN1C1	57134	broad.mit.edu	37	1	25944781	25944781	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:25944781C>T	uc001bkm.2	+	1	823	c.493C>T	c.(493-495)CAG>TAG	p.Q165*	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	165	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CGATGAGAGTCAGGAGCCCCA	0.637		NA											5	12					0	0	0	0
C1orf177	163747	broad.mit.edu	37	1	55279519	55279519	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:55279519G>T	uc001cyb.3	+	7	849	c.795G>T	c.(793-795)AAG>AAT	p.K265N	C1orf177_uc001cya.3_Missense_Mutation_p.K265N	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	265											0						TGAATTTCAAGAGCTTTGTAG	0.413		NA											6	60					0.00116845	0.00344411	1	0
PRKAA2	5563	broad.mit.edu	37	1	57140142	57140142	+	Silent	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:57140142A>C	uc001cyk.3	+	2	254	c.183A>C	c.(181-183)ATA>ATC	p.I61I		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	61	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TTGGAAAAATAAAACGAGAAA	0.294		NA											18	62					0	0	0	0
USP33	23032	broad.mit.edu	37	1	78194375	78194375	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:78194375C>T	uc001dht.2	-	11	1180	c.833G>A	c.(832-834)TGT>TAT	p.C278Y	USP33_uc001dhs.2_5'UTR|USP33_uc001dhu.2_Missense_Mutation_p.C247Y|USP33_uc001dhv.2_Missense_Mutation_p.C83Y|USP33_uc001dhw.2_Missense_Mutation_p.C278Y	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	278					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						ATCCATTAAACATCGAAGGAA	0.353		NA											28	50					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152283083	152283083	+	Missense_Mutation	SNP	C	C	T	rs148844389	byFrequency	TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:152283083C>T	uc001ezu.1	-	3	4315	c.4279G>A	c.(4279-4281)GCA>ACA	p.A1427T	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1427	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCACGTGCGGACTCTTTG	0.557		NA							Ichthyosis				38	318					0	0	0	0
PPOX	5498	broad.mit.edu	37	1	161140306	161140306	+	Silent	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:161140306G>A	uc001fyj.2	+	10	1385	c.1095G>A	c.(1093-1095)GTG>GTA	p.V365V	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Silent_p.V365V|PPOX_uc001fyl.2_Silent_p.V331V|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Silent_p.V203V|PPOX_uc001fyh.2_Silent_p.V203V|PPOX_uc010pkg.1_Silent_p.V203V|PPOX_uc009wuc.1_Intron|PPOX_uc010pkh.1_Silent_p.V110V|PPOX_uc001fyi.2_Silent_p.V203V	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	365					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCCTCAGAGTGACTGTGAGGA	0.542		NA							Porphyria_Variegata				10	66					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563958	176563958	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:176563958G>T	uc001gkz.2	+	3	2382	c.1218G>T	c.(1216-1218)TTG>TTT	p.L406F	PAPPA2_uc001gky.1_Missense_Mutation_p.L406F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	406					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCCGCTCTTTGCTCCTGGGGG	0.587		NA											32	59					4.32e-19	1.45e-18	1	0
USH2A	7399	broad.mit.edu	37	1	216380633	216380633	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:216380633C>G	uc001hku.1	-	16	3685	c.3298G>C	c.(3298-3300)GAG>CAG	p.E1100Q	USH2A_uc001hkv.2_Missense_Mutation_p.E1100Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1100	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATTGATCCTCTGTTGTGTAG	0.373		NA								HNSCC(13;0.011)			9	48					0	0	0	0
HEATR1	55127	broad.mit.edu	37	1	236760193	236760193	+	Silent	SNP	T	T	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:236760193T>C	uc001hyd.1	-	6	812	c.687A>G	c.(685-687)GTA>GTG	p.V229V		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	229					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CCTCTGCAGCTACCAGCGCCG	0.448		NA											10	80					0	0	0	0
OR14A16	284532	broad.mit.edu	37	1	247978414	247978414	+	Silent	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:247978414G>A	uc001idm.1	-	1	618	c.618C>T	c.(616-618)TTC>TTT	p.F206F		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAAAACAGCAGAAATCCAAAA	0.373		NA											4	50					0	0	0	0
OR2T27	403239	broad.mit.edu	37	1	248814121	248814121	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:248814121C>T	uc010pzo.1	-	1	65	c.65G>A	c.(64-66)CGT>CAT	p.R22H		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAGGGGAAACGGGCGTTGCT	0.483		NA											13	86					0	0	0	0
CCDC6	8030	broad.mit.edu	37	10	61666054	61666054	+	Silent	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:61666054A>C	uc001jks.3	-	1	765	c.129T>G	c.(127-129)GGT>GGG	p.G43G		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	43	Poly-Gly.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		CCGACTTCccaccgccgccgc	0.537		NA											10	51					0	0	0	0
TNKS2	80351	broad.mit.edu	37	10	93602105	93602105	+	Silent	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:93602105C>T	uc001khp.2	+	16	2313	c.2016C>T	c.(2014-2016)TGC>TGT	p.C672C		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	672					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				ATGTAAATTGCCGCGATACCC	0.418		NA											4	44					0	0	0	0
PDE6C	5146	broad.mit.edu	37	10	95386572	95386572	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:95386572G>T	uc001kiu.3	+	7	1153	c.1015G>T	c.(1015-1017)GCA>TCA	p.A339S		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	339	GAF 2.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GACGCCTCCTGCAGACCACTG	0.378		NA											6	39					8.13e-05	0.000247141	1	0
C10orf95	79946	broad.mit.edu	37	10	104210810	104210810	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:104210810C>T	uc001kvo.1	-	2	253	c.178G>A	c.(178-180)GGC>AGC	p.G60S	uc001kvp.1_Intron|uc001kvq.1_Intron|uc001kvr.1_5'Flank	NM_024886	NP_079162	Q9H7T3	CJ095_HUMAN	hypothetical protein LOC79946	60	Arg/Pro-rich.									liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		CGGCGGCGGCCAGACGCCCTG	0.716		NA											7	16					0	0	0	0
STK33	65975	broad.mit.edu	37	11	8414255	8414255	+	Silent	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:8414255A>C	uc001mgi.1	-	12	2266	c.1347T>G	c.(1345-1347)TCT>TCG	p.S449S	STK33_uc001mgj.1_Silent_p.S449S|STK33_uc001mgk.1_Silent_p.S449S|STK33_uc010rbn.1_Silent_p.S408S|STK33_uc001mgl.3_Silent_p.S262S	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	449						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		CATAAGCAGTAGACTGCAAAT	0.378		NA											28	49					0	0	0	0
TRIM48	79097	broad.mit.edu	37	11	55032644	55032644	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:55032644G>A	uc010rid.1	+	2	399	c.313G>A	c.(313-315)GAG>AAG	p.E105K		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	89	B box-type.					intracellular	zinc ion binding				0						CCTGAGCTCTGAGGAGCAAAT	0.483		NA											8	61					0	0	0	0
OR4C6	219432	broad.mit.edu	37	11	55433284	55433284	+	Silent	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:55433284G>A	uc001nht.3	+	3	907	c.642G>A	c.(640-642)GCG>GCA	p.A214A	OR4C6_uc010rik.1_Silent_p.A214A	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCTTAATTGCGTCCTACACGG	0.517		NA											30	86					0	0	0	0
CYBASC3	220002	broad.mit.edu	37	11	61124072	61124072	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:61124072A>T	uc001nrf.3	-	1	290	c.114T>A	c.(112-114)AAT>AAA	p.N38K	CYBASC3_uc010rlh.1_Missense_Mutation_p.N55K|CYBASC3_uc001nrg.2_Missense_Mutation_p.N38K|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Missense_Mutation_p.N38K|CYBASC3_uc001nri.2_Intron|CYBASC3_uc009yno.2_Missense_Mutation_p.N38K	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	38	Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						AGATGCTGCCATTCCAGGCAA	0.547		NA											24	91					0	0	0	0
CYBASC3	220002	broad.mit.edu	37	11	61124075	61124075	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:61124075C>A	uc001nrf.3	-	1	287	c.111G>T	c.(109-111)TGG>TGT	p.W37C	CYBASC3_uc010rlh.1_Missense_Mutation_p.W54C|CYBASC3_uc001nrg.2_Missense_Mutation_p.W37C|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Missense_Mutation_p.W37C|CYBASC3_uc001nri.2_Intron|CYBASC3_uc009yno.2_Missense_Mutation_p.W37C	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	37	Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						TGCTGCCATTCCAGGCAAAGC	0.547		NA											20	90					2.38e-13	7.9e-13	1	0
CACNA1C	775	broad.mit.edu	37	12	2224421	2224421	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:2224421T>A	uc009zdu.1	+	2	394	c.81T>A	c.(79-81)CAT>CAA	p.H27Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.H27Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qke.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.H27Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.H27Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qko.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qku.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qks.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.H27Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	27	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCCCGCCCATGCCAACATGA	0.622		NA											6	9					0	0	0	0
ETV6	2120	broad.mit.edu	37	12	12022466	12022466	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:12022466G>A	uc001qzz.2	+	5	846	c.572G>A	c.(571-573)CGG>CAG	p.R191Q	ETV6_uc001raa.1_5'UTR	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	191						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				ACAAATCACCGGCCTTCTCCT	0.642		NA	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								56	336					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20832977	20832977	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:20832977C>G	uc001reh.1	+	16	3220	c.3198C>G	c.(3196-3198)TTC>TTG	p.F1066L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1066	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGAAGACTTTCAAAAGGAGAA	0.358		NA											7	57					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	21967641	21967641	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:21967641G>A	uc001rfi.1	-	33	4059	c.4039C>T	c.(4039-4041)CGC>TGC	p.R1347C	ABCC9_uc001rfh.2_Missense_Mutation_p.R1347C|ABCC9_uc001rfj.1_Missense_Mutation_p.R1311C	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1347	Cytoplasmic (Potential).|ATP 2 (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGCCAGTGCGACCACATATG	0.388		NA											8	47					0	0	0	0
RASAL1	8437	broad.mit.edu	37	12	113537802	113537802	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:113537802C>A	uc001tum.1	-	22	2640	c.2347G>T	c.(2347-2349)GAT>TAT	p.D783Y	RASAL1_uc010syp.1_Missense_Mutation_p.D784Y|RASAL1_uc001tul.2_Missense_Mutation_p.D755Y|RASAL1_uc001tun.1_Missense_Mutation_p.D785Y	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	783					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TGGGCACGATCCAGGTCTGCG	0.677		NA											13	34					5.51e-06	1.71e-05	1	0
DIS3	22894	broad.mit.edu	37	13	73346872	73346872	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr13:73346872G>A	uc001vix.3	-	9	1719	c.1345C>T	c.(1345-1347)CTT>TTT	p.L449F	DIS3_uc001viy.3_Missense_Mutation_p.L419F|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	449					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AGAAAACTAAGAACAGCCTGT	0.363		NA								Multiple Myeloma(4;0.011)			4	98					0	0	0	0
PCCA	5095	broad.mit.edu	37	13	100861712	100861712	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr13:100861712G>A	uc001voo.2	+	7	633	c.595G>A	c.(595-597)GTC>ATC	p.V199I	PCCA_uc010aga.2_Missense_Mutation_p.V173I|PCCA_uc010tiz.1_Missense_Mutation_p.V199I	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	199	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGATGGAGTAGTCAAGGTGAG	0.338		NA											10	63					0	0	0	0
NEIL1	79661	broad.mit.edu	37	15	75641409	75641409	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr15:75641409G>A	uc002bad.2	+	2	669	c.163G>A	c.(163-165)GAG>AAG	p.E55K	NEIL1_uc002bae.2_Missense_Mutation_p.E141K	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	55					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						CCGCGGCAAGGAGCTGCGCCT	0.647		NA						BER_DNA_glycosylases					4	49					0	0	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750590	79750590	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr15:79750590A>T	uc002bew.1	+	2	2176	c.2101A>T	c.(2101-2103)AAA>TAA	p.K701*	KIAA1024_uc010unk.1_Nonsense_Mutation_p.K701*	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	701						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GGCCTTAAAAAAAAGCCTCTT	0.552		NA											12	108					0	0	0	0
PKD1	5310	broad.mit.edu	37	16	2159543	2159543	+	Silent	SNP	G	G	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:2159543G>C	uc002cos.1	-	15	5834	c.5625C>G	c.(5623-5625)GTC>GTG	p.V1875V	PKD1_uc002cot.1_Silent_p.V1875V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1875	PKD 14.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						ACGTGGCTGAGACCCAGCTGA	0.652		NA											8	13					0	0	0	0
ALG1	56052	broad.mit.edu	37	16	5127458	5127458	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:5127458C>A	uc002cym.2	+	5	593	c.552C>A	c.(550-552)TTC>TTA	p.F184L	ALG1_uc002cyj.2_Missense_Mutation_p.F73L|ALG1_uc002cyn.2_Missense_Mutation_p.F184L|ALG1_uc010bue.2_Missense_Mutation_p.F73L|ALG1_uc010uxy.1_Missense_Mutation_p.F73L	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	184	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				ACGAGAAGTTCTTTGGGCGCC	0.552		NA											19	100					1.02e-10	3.35e-10	1	0
RNF40	9810	broad.mit.edu	37	16	30779808	30779808	+	Silent	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:30779808C>A	uc002dzq.2	+	13	2059	c.1936C>A	c.(1936-1938)CGG>AGG	p.R646R	RNF40_uc010caa.2_Silent_p.R646R|RNF40_uc010cab.2_Silent_p.R546R|RNF40_uc010vfa.1_5'UTR|RNF40_uc002dzr.2_Silent_p.R646R|RNF40_uc010vfb.1_Silent_p.R338R|RNF40_uc010vfc.1_5'UTR	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	646	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			AGAAACCAAGCGGAAGGAATC	0.597		NA											4	75					0.00024832	0.000751641	1	0
ANKRD11	29123	broad.mit.edu	37	16	89348419	89348419	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:89348419G>A	uc002fmx.1	-	9	4992	c.4531C>T	c.(4531-4533)CCC>TCC	p.P1511S	ANKRD11_uc002fmy.1_Missense_Mutation_p.P1511S|ANKRD11_uc002fnc.1_Missense_Mutation_p.P1511S|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.P1468S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1511	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGCACGCGGGGCGGGCTGTCC	0.632		NA											4	66					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578534	7578534	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:7578534C>G	uc002gim.2	-	5	590	c.396G>C	c.(394-396)AAG>AAC	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	15					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10447033	10447033	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:10447033G>A	uc010coi.2	-	8	864	c.736C>T	c.(736-738)CGC>TGC	p.R246C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R246C|MYH2_uc010coj.2_Missense_Mutation_p.R246C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	246	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTACAAAGCGAGAGGAGTTG	0.448		NA											6	54					0	0	0	0
TOP2A	7153	broad.mit.edu	37	17	38552685	38552685	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:38552685T>G	uc002huq.2	-	28	3696	c.3570A>C	c.(3568-3570)CAA>CAC	p.Q1190H		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1190					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GAAGTCCGACTTGTTCATCTT	0.413		NA											12	108					0	0	0	0
STXBP4	252983	broad.mit.edu	37	17	53158448	53158448	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:53158448A>C	uc002iuf.1	+	16	1600	c.1393A>C	c.(1393-1395)ACA>CCA	p.T465P	STXBP4_uc010dcd.1_Missense_Mutation_p.T443P	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	465						cytoplasm	calcium ion binding			ovary(1)	1						GACTTCCCTCACACCACTGGG	0.393		NA											4	47					0	0	0	0
STRADA	92335	broad.mit.edu	37	17	61781730	61781730	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:61781730C>A	uc002jbm.2	-	11	1230	c.1071G>T	c.(1069-1071)GAG>GAT	p.E357D	STRADA_uc002jbn.2_Missense_Mutation_p.E299D|STRADA_uc002jbo.2_Missense_Mutation_p.E320D|STRADA_uc002jbp.2_Missense_Mutation_p.E320D|STRADA_uc002jbq.2_Missense_Mutation_p.E299D|STRADA_uc010wpq.1_Intron|STRADA_uc010wpr.1_Intron|STRADA_uc010ddw.2_Missense_Mutation_p.E328D|STRADA_uc002jbr.2_3'UTR	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	357	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						GAAGGCACTGCTCCACAAAGT	0.662		NA											4	25					0.00116845	0.00344411	1	0
AXIN2	8313	broad.mit.edu	37	17	63526139	63526139	+	Silent	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:63526139C>T	uc002jfi.2	-	11	2776	c.2487G>A	c.(2485-2487)CCG>CCA	p.P829P	AXIN2_uc002jfh.2_Silent_p.P764P	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	829	DIX.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						CTTCATACATCGGGAGCACCG	0.507		NA							Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				15	88					0	0	0	0
GPS1	2873	broad.mit.edu	37	17	80013938	80013938	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:80013938G>A	uc002kdl.1	+	8	953	c.908G>A	c.(907-909)CGG>CAG	p.R303Q	GPS1_uc002kdk.1_Missense_Mutation_p.R339Q|GPS1_uc010dij.1_Missense_Mutation_p.R338Q|GPS1_uc002kdm.1_Missense_Mutation_p.R283Q|GPS1_uc002kdn.1_Missense_Mutation_p.R299Q|GPS1_uc002kdo.1_Missense_Mutation_p.R302Q|GPS1_uc010wvh.1_Missense_Mutation_p.R295Q	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	303					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			ACCTTTGACCGGCAGGAGCTG	0.657		NA											4	29					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7043287	7043287	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr18:7043287A>C	uc002knm.2	-	8	1188	c.1094T>G	c.(1093-1095)TTG>TGG	p.L365W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	365	Laminin EGF-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTTCTGCAAGCAATTTAT	0.388		NA											58	145					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50977000	50977000	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr18:50977000T>G	uc002lfe.1	+	23	3947	c.3360T>G	c.(3358-3360)ATT>ATG	p.I1120M	DCC_uc010dpf.1_Missense_Mutation_p.I755M	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1120	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGGCTGTGATTTGCACCCGAC	0.488		NA											6	36					0	0	0	0
AP3D1	8943	broad.mit.edu	37	19	2121250	2121250	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:2121250C>T	uc002luz.2	-	13	1385	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	AP3D1_uc002luy.2_Missense_Mutation_p.E297K|AP3D1_uc002lva.2_Missense_Mutation_p.E388K	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	388	HEAT 8.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTACCCTCTGCCTTGTCT	0.542		NA											6	69					0	0	0	0
ZNF823	55552	broad.mit.edu	37	19	11832973	11832973	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:11832973T>G	uc002msm.2	-	4	1502	c.1376A>C	c.(1375-1377)CAA>CCA	p.Q459P	ZNF823_uc010xmd.1_Missense_Mutation_p.Q277P|ZNF823_uc010dyi.1_Missense_Mutation_p.Q415P	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	459	C2H2-type 11; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCATGATTTTGAAAGGAAGA	0.423		NA								HNSCC(68;0.2)			6	104					0	0	0	0
NCAN	1463	broad.mit.edu	37	19	19334919	19334919	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:19334919A>G	uc002nlz.2	+	4	664	c.565A>G	c.(565-567)ATT>GTT	p.I189V	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	189	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CTCAGCCATCATTGCAGCCCC	0.602		NA											21	45					0	0	0	0
CILP2	148113	broad.mit.edu	37	19	19655256	19655256	+	Silent	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:19655256G>A	uc002nmv.3	+	8	1987	c.1902G>A	c.(1900-1902)CTG>CTA	p.L634L	CILP2_uc002nmw.3_Silent_p.L640L	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	634						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						ACGGCGAGCTGGCTCCACTGC	0.736		NA											7	123					0	0	0	0
PSG8	440533	broad.mit.edu	37	19	43259212	43259212	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:43259212C>T	uc002ouo.2	-	4	1014	c.916G>A	c.(916-918)GGA>AGA	p.G306R	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.G145R|PSG8_uc002ouh.2_Missense_Mutation_p.G306R|PSG8_uc010ein.2_Missense_Mutation_p.G184R|PSG8_uc002ouj.3_Missense_Mutation_p.G88R|PSG8_uc002ouk.3_Missense_Mutation_p.G145R|PSG8_uc002oul.3_Missense_Mutation_p.G306R|PSG8_uc002oum.3_Missense_Mutation_p.G213R|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.G213R	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	306	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				TGATAGGGTCCTGTTTCATTT	0.498		NA											46	206					0	0	0	0
SYT3	84258	broad.mit.edu	37	19	51135984	51135984	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:51135984A>T	uc002pst.2	-	2	867	c.233T>A	c.(232-234)TTG>TAG	p.L78*	SYT3_uc002psv.2_Nonsense_Mutation_p.L78*|SYT3_uc010ycd.1_Nonsense_Mutation_p.L78*	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	78	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CACCCAGCACAACTTCCAGGA	0.632		NA											6	99					0	0	0	0
HEATR5B	54497	broad.mit.edu	37	2	37284598	37284598	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:37284598T>G	uc002rpp.1	-	15	2181	c.2085A>C	c.(2083-2085)GAA>GAC	p.E695D		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	695							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CCGCTACCAGTTCTCTAAGAA	0.363		NA											6	23					0	0	0	0
QPCT	25797	broad.mit.edu	37	2	37599902	37599902	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:37599902G>A	uc002rqg.2	+	7	1140	c.1018G>A	c.(1018-1020)GAT>AAT	p.D340N	QPCT_uc002rqh.2_Missense_Mutation_p.D291N	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	340					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				AGAAAATTTGGATGAATCAAC	0.358		NA											4	75					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80816531	80816531	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:80816531T>G	uc010ysh.1	+	14	2115	c.2110T>G	c.(2110-2112)TGG>GGG	p.W704G	CTNNA2_uc010yse.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysf.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysg.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysi.1_Missense_Mutation_p.W336G|CTNNA2_uc010ysj.1_Missense_Mutation_p.W33G	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	704					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGTGGCCAAATGGGACGACAG	0.498		NA											9	81					0	0	0	0
ZRANB3	84083	broad.mit.edu	37	2	135965229	135965229	+	Silent	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:135965229C>T	uc002tum.2	-	19	2901	c.2784G>A	c.(2782-2784)GCG>GCA	p.A928A	ZRANB3_uc002tuk.2_Silent_p.A471A|ZRANB3_uc002tul.2_Silent_p.A926A	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	928						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		CCCAAGAGTTCGCTTTACATG	0.428		NA											28	194					0	0	0	0
STK39	27347	broad.mit.edu	37	2	169020294	169020294	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:169020294A>C	uc002uea.2	-	4	687	c.527T>G	c.(526-528)GTT>GGT	p.V176G		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	176	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						GCCTTCCAAAACCTCTTTAAG	0.363		NA											5	50					0	0	0	0
CERKL	375298	broad.mit.edu	37	2	182414397	182414397	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:182414397G>A	uc002unx.2	-	7	1038	c.937C>T	c.(937-939)CCT>TCT	p.P313S	CERKL_uc002uny.2_Missense_Mutation_p.P287S|CERKL_uc010zfm.1_Missense_Mutation_p.P269S|CERKL_uc002unz.2_Missense_Mutation_p.P35S|CERKL_uc002uoa.2_Missense_Mutation_p.P218S|CERKL_uc002uob.2_Missense_Mutation_p.P35S|CERKL_uc002uoc.2_Missense_Mutation_p.P174S|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Missense_Mutation_p.P82S|CERKL_uc002uoe.2_Missense_Mutation_p.P287S|CERKL_uc002unw.2_5'Flank	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	313	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATCACATGAGGAACTCCATGA	0.343		NA											11	80					0	0	0	0
SMTN	6525	broad.mit.edu	37	22	31491537	31491537	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr22:31491537C>A	uc003ajl.1	+	13	2021	c.1803C>A	c.(1801-1803)GAC>GAA	p.D601E	SMTN_uc003ajk.1_Missense_Mutation_p.D601E|SMTN_uc003ajm.1_Missense_Mutation_p.D601E|SMTN_uc011ale.1_Missense_Mutation_p.D686E|SMTN_uc011alf.1_Missense_Mutation_p.D657E|SMTN_uc003ajn.1_Missense_Mutation_p.D624E|SMTN_uc011alg.1_Missense_Mutation_p.D57E|SMTN_uc003ajo.1_Missense_Mutation_p.D200E|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Missense_Mutation_p.D57E	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	601					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						AGAGCACGGACTTTGAAGAGC	0.577		NA											15	37					3.27e-08	1.05e-07	1	0
ACO2	50	broad.mit.edu	37	22	41919936	41919936	+	Silent	SNP	G	G	A	rs148997312		TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr22:41919936G>A	uc003bac.2	+	12	1495	c.1473G>A	c.(1471-1473)ACG>ACA	p.T491T	ACO2_uc003bad.2_Silent_p.T516T	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	491					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCTTTGTCACGTCCCCAGAGG	0.617		NA											9	33					0	0	0	0
KIAA2018	205717	broad.mit.edu	37	3	113378750	113378750	+	Silent	SNP	G	G	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:113378750G>C	uc003eam.2	-	7	2190	c.1779C>G	c.(1777-1779)CTC>CTG	p.L593L	KIAA2018_uc003eal.2_Silent_p.L537L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	593					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GAGCAGGGAGGAGTGGCAAAG	0.473		NA											30	67					0	0	0	0
SRPRB	58477	broad.mit.edu	37	3	133538447	133538447	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:133538447C>A	uc003epx.1	+	7	669	c.653C>A	c.(652-654)TCC>TAC	p.S218Y		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	218						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						CTGGACAGTTCCAGCACTGCC	0.517		NA											7	71					0.000673444	0.00201139	1	0
HTR3D	200909	broad.mit.edu	37	3	183754191	183754191	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:183754191G>T	uc011bqv.1	+	4	409	c.409G>T	c.(409-411)GCT>TCT	p.A137S	HTR3D_uc003fmj.2_Missense_Mutation_p.A2S|HTR3D_uc011bqu.1_Missense_Mutation_p.A76S|HTR3D_uc010hxp.2_Intron	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	137	Extracellular (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGGTCTCATGGCTAGTATGTC	0.507		NA											16	23					4.15e-12	1.37e-11	1	0
PYDC2	152138	broad.mit.edu	37	3	191179054	191179054	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:191179054C>A	uc011bso.1	+	1	103	c.103C>A	c.(103-105)CTG>ATG	p.L35M		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	35	DAPIN.					cytoplasm|nucleus					0						AACAATCTCCCTGGGAAAGGA	0.537		NA											10	96					7.48e-07	2.36e-06	1	0
MUC20	200958	broad.mit.edu	37	3	195447901	195447901	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:195447901C>G	uc010hzo.2	+	1	149	c.23C>G	c.(22-24)GCT>GGT	p.A8G		NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	8					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TGGGGTCTGGCTCTGCCCCTT	0.617		NA											2	7					0	0	0	0
SLC26A1	10861	broad.mit.edu	37	4	985266	985266	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr4:985266C>A	uc003gcb.2	-	3	604	c.226G>T	c.(226-228)GGG>TGG	p.G76W	SLC26A1_uc003gbx.2_Missense_Mutation_p.G76W|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Missense_Mutation_p.G76W	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	76	Helical; (Potential).					integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ATGACCAGCCCAGACATGACG	0.662		NA											5	88					0.000602214	0.00180664	1	0
PCDHB1	29930	broad.mit.edu	37	5	140432406	140432406	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr5:140432406A>T	uc003lik.1	+	1	1428	c.1351A>T	c.(1351-1353)ATA>TTA	p.I451L		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATCCTCCAATATTTCGGGA	0.423		NA											9	60					0	0	0	0
HTR4	3360	broad.mit.edu	37	5	147845444	147845444	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr5:147845444C>G	uc003lpi.1	-	7	1285	c.1121G>C	c.(1120-1122)AGA>ACA	p.R374T	HTR4_uc010jgu.1_RNA|HTR4_uc003lpj.1_Intron	NM_199453	NP_955525	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform g	Error:Variant_position_missing_in_Q13639_after_alignment					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGGAACTGGTCTATTGCAGAA	0.443		NA											5	144					0	0	0	0
BCKDHB	594	broad.mit.edu	37	6	80878708	80878708	+	Silent	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr6:80878708G>A	uc003pjd.2	+	5	661	c.594G>A	c.(592-594)CAG>CAA	p.Q198Q	BCKDHB_uc003pje.2_Silent_p.Q198Q	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	198					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		ATCATTCTCAGAGTCCTGAAG	0.423		NA											7	81					0	0	0	0
UNC93A	54346	broad.mit.edu	37	6	167721317	167721317	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr6:167721317C>T	uc003qvq.2	+	7	1202	c.1027C>T	c.(1027-1029)CGT>TGT	p.R343C	UNC93A_uc003qvr.2_Missense_Mutation_p.R301C	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	343						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTGGAGACCTCGTGCTGACCA	0.617		NA											7	63					0	0	0	0
CHST12	55501	broad.mit.edu	37	7	2472309	2472309	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:2472309T>G	uc003smc.2	+	2	170	c.35T>G	c.(34-36)GTG>GGG	p.V12G	CHST12_uc003smd.2_Missense_Mutation_p.V12G	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	12	Helical; Signal-anchor for type II membrane protein; (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTGTGGCTGGTGCTGGGGTCG	0.662		NA											8	55					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11468652	11468652	+	Silent	SNP	C	C	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:11468652C>G	uc003ssf.3	-	14	3417	c.3165G>C	c.(3163-3165)GTG>GTC	p.V1055V		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1055	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AACGAACCTTCACACCACTCC	0.517		NA								HNSCC(18;0.044)			17	317					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100483362	100483362	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:100483362C>T	uc003uwy.2	+	12	1626	c.1358C>T	c.(1357-1359)TCA>TTA	p.S453L	SRRT_uc010lhl.1_Missense_Mutation_p.S452L|SRRT_uc003uxa.2_Missense_Mutation_p.S452L|SRRT_uc003uwz.2_Missense_Mutation_p.S453L	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	453					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTGGCGCTCTCAGAGCCCCAG	0.537		NA											18	99					0	0	0	0
CPA4	51200	broad.mit.edu	37	7	129948151	129948151	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:129948151G>T	uc003vpr.2	+	8	754	c.707G>T	c.(706-708)CGA>CTA	p.R236L	CPA4_uc011kpd.1_Missense_Mutation_p.R203L|CPA4_uc011kpe.1_Missense_Mutation_p.R132L	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	236					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TTTCAGAACCGATTATGGAGG	0.557		NA											18	44					6.94e-10	2.28e-09	1	0
FAM110B	90362	broad.mit.edu	37	8	59059406	59059406	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:59059406T>C	uc003xtj.1	+	5	1497	c.617T>C	c.(616-618)GTG>GCG	p.V206A		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	206						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				ATCCGCAAGGTGACCAGCGTG	0.657		NA											11	72					0	0	0	0
SULF1	23213	broad.mit.edu	37	8	70536227	70536227	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:70536227G>A	uc010lza.1	+	15	2362	c.1645G>A	c.(1645-1647)GAA>AAA	p.E549K	SULF1_uc003xyd.2_Missense_Mutation_p.E549K|SULF1_uc003xye.2_Missense_Mutation_p.E549K|SULF1_uc003xyf.2_Missense_Mutation_p.E549K|SULF1_uc003xyg.2_Missense_Mutation_p.E549K|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	549					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CTTGTCCGTCGAATTTGAAGG	0.408		NA											11	63					0	0	0	0
TEK	7010	broad.mit.edu	37	9	27220088	27220088	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr9:27220088G>A	uc003zqi.3	+	21	3587	c.3145G>A	c.(3145-3147)GAG>AAG	p.E1049K	TEK_uc011lno.1_Missense_Mutation_p.E1006K|TEK_uc011lnp.1_Missense_Mutation_p.E901K	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1049	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGAACTCTACGAGAAGCTGCC	0.532		NA											6	96					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627757	43627757	+	Silent	SNP	A	A	G			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr9:43627757A>G	uc011lrb.1	-	4	959	c.930T>C	c.(928-930)TGT>TGC	p.C310C		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	310						integral to membrane					0						CTTCCATCTGACAGGTCTCTG	0.532		NA											4	216					0	0	0	0
ASPN	54829	broad.mit.edu	37	9	95236914	95236914	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr9:95236914G>C	uc004ase.1	-	2	510	c.266C>G	c.(265-267)TCA>TGA	p.S89*	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_Nonsense_Mutation_p.S89*	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	89	LRRNT.|Cys-rich.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						ACCTAAATCTGAGCAATGTAC	0.323		NA											4	26					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734913	12734913	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chrX:12734913G>A	uc004cuz.1	+	15	2841	c.2335G>A	c.(2335-2337)GAC>AAC	p.D779N	FRMPD4_uc011mij.1_Missense_Mutation_p.D771N	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	779					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GTCAAGCGATGACATCATTGA	0.592		NA											9	100					0	0	0	0
GLOD5	392465	broad.mit.edu	37	X	48629492	48629492	+	Silent	SNP	C	C	T			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chrX:48629492C>T	uc011mmh.1	+	3	392	c.351C>T	c.(349-351)CAC>CAT	p.H117H		NM_001080489	NP_001073958			glyoxalase domain containing 5												0						TGATCCAGCACCTCAAGGTGA	0.483		NA											18	10					0	0	0	0
EIF4G2	1982	broad.mit.edu	37	11	10821256	10821260	+	Frame_Shift_Del	DEL	CCTTT	CCTTT	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:10821256_10821260delCCTTT	uc001mjc.2	-	19	2580_2584	c.2163_2167delAAAGG	c.(2161-2169)GGAAAGGGAfs	p.G721fs	EIF4G2_uc001mjb.2_Frame_Shift_Del_p.G515fs|EIF4G2_uc009ygf.2_Frame_Shift_Del_p.G515fs|EIF4G2_uc001mjd.2_Frame_Shift_Del_p.G683fs	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	721_723	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAACTCAGTCCCTTTCCTTCCAAAA	0.385		NA											10	46	---	---	---	---	NA	NA	NA	NA
PAN2	9924	broad.mit.edu	37	12	56717351	56717351	+	Frame_Shift_Del	DEL	T	T	-	rs138946880		TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:56717351delT	uc001skx.2	-	15	2589	c.2216delA	c.(2215-2217)GATfs	p.D739fs	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Frame_Shift_Del_p.D738fs|PAN2_uc001sky.2_Frame_Shift_Del_p.D735fs	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	739					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GACAAGAATATCTGGCAGATG	0.488		NA											26	49	---	---	---	---	NA	NA	NA	NA
HECTD1	25831	broad.mit.edu	37	14	31597034	31597034	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr14:31597034delG	uc001wrc.1	-	26	5427	c.4938delC	c.(4936-4938)TCCfs	p.S1646fs	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Frame_Shift_Del_p.S1114fs	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1646	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CACTCTCACTGGAAGTTGATG	0.353		NA											17	80	---	---	---	---	NA	NA	NA	NA
ZNF440	126070	broad.mit.edu	37	19	11943494	11943494	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:11943494delT	uc002msp.1	+	4	1659	c.1503delT	c.(1501-1503)CCTfs	p.P501fs		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCCAGTTCCTTTTGATATCA	0.413		NA											12	52	---	---	---	---	NA	NA	NA	NA
CLSTN2	64084	broad.mit.edu	37	3	140167413	140167413	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:140167413delC	uc003etn.2	+	6	1030	c.840delC	c.(838-840)TTCfs	p.F280fs	CLSTN2_uc003etm.2_Frame_Shift_Del_p.F280fs	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	280	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGCCCCTGTTCCCCAGCATCC	0.512		NA								HNSCC(16;0.037)			72	112	---	---	---	---	NA	NA	NA	NA
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:92146721delT	uc003uly.2	-	5	1204	c.1108delA	c.(1108-1110)ATTfs	p.I370fs	PEX1_uc011khr.1_Frame_Shift_Del_p.I162fs|PEX1_uc010ley.2_Frame_Shift_Del_p.I370fs|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353		NA											18	1074	---	---	---	---	NA	NA	NA	NA
LMTK2	22853	broad.mit.edu	37	7	97820131	97820132	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:97820131_97820132delAG	uc003upd.1	+	10	1383_1384	c.1090_1091delAG	c.(1090-1092)AGAfs	p.R364fs		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	364	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CCAAGTCATTAGAGAGAGAGAC	0.495		NA											9	1358	---	---	---	---	NA	NA	NA	NA
SSPO	23145	broad.mit.edu	37	7	149488643	149488643	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:149488643delC	uc010lpk.2	+	35	5094	c.5094delC	c.(5092-5094)GGCfs	p.G1698fs		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1698	TSP type-1 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCCTGGGGCCCCTGGAGCC	0.721		NA											2	4	---	---	---	---	NA	NA	NA	NA
PTDSS1	9791	broad.mit.edu	37	8	97318687	97318687	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:97318687delA	uc003yht.1	+	8	1012	c.910delA	c.(910-912)ACCfs	p.T304fs	PTDSS1_uc003yhu.1_Frame_Shift_Del_p.T158fs	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	304	Helical; (Potential).				phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TGAGTTGAATACCTTCTTCTT	0.393		NA											67	92	---	---	---	---	NA	NA	NA	NA
