Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
RER1	11079	broad.mit.edu	37	1	2330854	2330854	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:2330854G>A	uc001aje.1	+	4	378	c.187G>A	c.(187-189)GGT>AGT	p.G63S	RER1_uc001ajf.1_Missense_Mutation_p.G63S	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	63	Helical; (Potential).				retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		TCTCTTTCAGGGTTGGTACAT	0.463		NA											9	93					0	0	0	0
C1orf63	57035	broad.mit.edu	37	1	25573139	25573139	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:25573139G>A	uc001bjw.2	-	2	568	c.316C>T	c.(316-318)CGG>TGG	p.R106W		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	106	Arg-rich.									pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAAGGAGACCGGTAGTATCTC	0.672		NA											8	67					0	0	0	0
TMEM57	55219	broad.mit.edu	37	1	25810763	25810763	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:25810763C>A	uc001bkk.2	+	7	1513	c.1311C>A	c.(1309-1311)AAC>AAA	p.N437K	TMEM57_uc009vru.2_Missense_Mutation_p.N210K|TMEM57_uc009vrv.2_Missense_Mutation_p.N79K	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	437						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGCAGAACAAGTACGTGC	0.572		NA											17	51					2.49e-13	3.08e-13	1	0
ZNHIT6	54680	broad.mit.edu	37	1	86146537	86146537	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:86146537G>T	uc001dlh.2	-	6	1204	c.1070C>A	c.(1069-1071)GCT>GAT	p.A357D	ZNHIT6_uc010osc.1_Missense_Mutation_p.A318D	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	357					box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						TATGTACTCAGCTTGACTTTG	0.308		NA											5	19					0.00116845	0.00127074	1	0
COL11A1	1301	broad.mit.edu	37	1	103364525	103364525	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:103364525T>C	uc001dul.2	-	55	4430	c.4112A>G	c.(4111-4113)GAG>GGG	p.E1371G	COL11A1_uc001duk.2_Missense_Mutation_p.E567G|COL11A1_uc001dum.2_Missense_Mutation_p.E1383G|COL11A1_uc001dun.2_Missense_Mutation_p.E1332G|COL11A1_uc009weh.2_Missense_Mutation_p.E1255G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1371	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTCTTCCCTCTGCACCTGC	0.269		NA											7	10					0	0	0	0
BCL9	607	broad.mit.edu	37	1	147091476	147091476	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:147091476C>T	uc001epq.2	+	8	2255	c.1515C>T	c.(1513-1515)CAC>CAT	p.H505H	BCL9_uc010ozr.1_Silent_p.H431H	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	505	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TCCATCAGCACGGGCCTCGGG	0.567		NA	T	IGH@|IGL@	B-ALL								41	100					0	0	0	0
KPRP	448834	broad.mit.edu	37	1	152732519	152732519	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:152732519A>T	uc001fal.1	+	2	513	c.455A>T	c.(454-456)AAC>ATC	p.N152I		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	152	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGTCCAGAACTATGTACCC	0.502		NA											48	107					0	0	0	0
INTS3	65123	broad.mit.edu	37	1	153745728	153745728	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:153745728G>A	uc009wom.2	+	31	3332	c.3111G>A	c.(3109-3111)GTG>GTA	p.V1037V	INTS3_uc001fct.2_Silent_p.V1037V|INTS3_uc001fcu.2_Silent_p.V729V|INTS3_uc001fcv.2_Silent_p.V831V|INTS3_uc010peb.1_Silent_p.V897V|INTS3_uc001fcw.2_Silent_p.V550V|INTS3_uc010pec.1_Silent_p.V550V|INTS3_uc001fcy.2_Silent_p.V400V|INTS3_uc001fcx.2_Silent_p.V334V	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	1038					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCTCTGCAGTGGGCTCTGACA	0.552		NA											42	74					0	0	0	0
ATP8B2	57198	broad.mit.edu	37	1	154316484	154316484	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:154316484G>T	uc001fex.2	+	18	1973	c.1973G>T	c.(1972-1974)CGG>CTG	p.R658L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	644	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGGACAGCCGGGAGGACAGG	0.632		NA											17	32					4.76e-15	5.98e-15	1	0
KIAA0907	22889	broad.mit.edu	37	1	155895555	155895555	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:155895555C>A	uc001fmi.1	-	7	785	c.761G>T	c.(760-762)GGT>GTT	p.G254V	KIAA0907_uc001fmj.1_Missense_Mutation_p.G254V|KIAA0907_uc009wrk.1_Intron|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.G254V|KIAA0907_uc001fmm.2_3'UTR	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	254											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GCAGCCTGGACCTTCCACCTT	0.458		NA											18	44					2.94e-08	3.53e-08	1	0
RHBG	57127	broad.mit.edu	37	1	156348086	156348086	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:156348086C>T	uc010pho.1	+	4	607	c.569C>T	c.(568-570)GCC>GTC	p.A190V	RHBG_uc010phm.1_Intron|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Missense_Mutation_p.A121V|RHBG_uc009wrz.2_Missense_Mutation_p.A158V|RHBG_uc001for.2_Missense_Mutation_p.A160V	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	190	Helical; (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					ACCTTTGGTGCCTACTTCGGG	0.642		NA											7	161					0	0	0	0
F11R	50848	broad.mit.edu	37	1	160969992	160969992	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:160969992T>A	uc009wtt.2	-	5	805	c.535A>T	c.(535-537)AGC>TGC	p.S179C	F11R_uc010pjv.1_Missense_Mutation_p.S130C|F11R_uc001fxe.3_Missense_Mutation_p.S179C|F11R_uc009wtu.2_Missense_Mutation_p.S179C|F11R_uc010pjw.1_Missense_Mutation_p.S183C|F11R_uc001fxf.3_Missense_Mutation_p.S179C	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	179	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GCACGGGTGCTTTTGGGATTC	0.512		NA											45	62					0	0	0	0
TMCO1	54499	broad.mit.edu	37	1	165737484	165737484	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:165737484G>A	uc001gdj.3	-	2	242	c.93C>T	c.(91-93)TAC>TAT	p.Y31Y	TMCO1_uc001gdl.3_Intron|TMCO1_uc001gdm.3_5'UTR|TMCO1_uc001gdk.3_Silent_p.Y19Y|TMCO1_uc001gdn.3_RNA|uc001gdo.2_5'Flank	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	31						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TGTCTGTCCTGTAAACCAGGA	0.373		NA											12	19					0	0	0	0
ILDR2	387597	broad.mit.edu	37	1	166892037	166892037	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:166892037G>C	uc001gdx.1	-	8	1060	c.1004C>G	c.(1003-1005)ACC>AGC	p.T335S		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	335	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TTCTGAGATGGTGTTGTTATC	0.478		NA											32	72					0	0	0	0
ADCY10	55811	broad.mit.edu	37	1	167868789	167868789	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:167868789C>T	uc001ger.2	-	6	812	c.514G>A	c.(514-516)GTG>ATG	p.V172M	ADCY10_uc009wvk.2_Missense_Mutation_p.V80M|ADCY10_uc010plj.1_Missense_Mutation_p.V19M|ADCY10_uc009wvl.2_Missense_Mutation_p.V171M|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	172	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						ACATCGTCCACTGCCTGACCA	0.507		NA											17	36					0	0	0	0
GLT25D2	23127	broad.mit.edu	37	1	183923934	183923934	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:183923934C>G	uc001gqr.2	-	7	1363	c.991G>C	c.(991-993)GTT>CTT	p.V331L	GLT25D2_uc010poj.1_Missense_Mutation_p.V331L|GLT25D2_uc001gqq.2_Missense_Mutation_p.V68L|GLT25D2_uc001gqs.2_Missense_Mutation_p.V211L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	331					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						TTAGGGACAACTGAGACATAC	0.448		NA											24	30					0	0	0	0
PTGS2	5743	broad.mit.edu	37	1	186645174	186645174	+	Nonsense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:186645174A>C	uc001gsb.2	-	8	1250	c.1113T>G	c.(1111-1113)TAT>TAG	p.Y371*	PTGS2_uc009wyo.2_Nonsense_Mutation_p.Y218*	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	371		For cyclooxygenase activity (By similarity).			cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GATGCCAGTGATAGAGGGTGT	0.383		NA											42	57					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196648779	196648779	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:196648779A>G	uc001gtj.3	+	6	886	c.646A>G	c.(646-648)ATA>GTA	p.I216V	CFH_uc001gti.3_Missense_Mutation_p.I216V|CFH_uc009wyw.2_Missense_Mutation_p.I216V|CFH_uc009wyx.2_Missense_Mutation_p.I152V	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	216	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CCCAGATGTTATAAATGGATC	0.299		NA											6	17					0	0	0	0
KIF21B	23046	broad.mit.edu	37	1	200978555	200978555	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:200978555G>A	uc001gvs.1	-	2	420	c.103C>T	c.(103-105)CCG>TCG	p.P35S	KIF21B_uc001gvr.1_Missense_Mutation_p.P35S|KIF21B_uc009wzl.1_Missense_Mutation_p.P35S|KIF21B_uc010ppn.1_Missense_Mutation_p.P35S	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	35	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGCTCTCCCGGGGTAACAGAG	0.577		NA											4	78					0	0	0	0
ADORA1	134	broad.mit.edu	37	1	203134630	203134630	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:203134630C>T	uc001gze.1	+	4	1016	c.583C>T	c.(583-585)CTC>TTC	p.L195F	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.L195F|ADORA1_uc010pqg.1_Missense_Mutation_p.L127F|ADORA1_uc009xak.1_Missense_Mutation_p.P120L|ADORA1_uc010pqh.1_Missense_Mutation_p.L228F	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	195	Helical; Name=5; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CCCGCTTCTCCTCATGGTCCT	0.552		NA											23	76					0	0	0	0
PCNXL2	80003	broad.mit.edu	37	1	233397851	233397851	+	Silent	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:233397851A>G	uc001hvl.2	-	3	655	c.420T>C	c.(418-420)CCT>CCC	p.P140P	PCNXL2_uc009xfu.2_5'Flank|PCNXL2_uc009xfv.1_5'Flank	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	140						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AGCGGAGGGGAGGCGTGGAGA	0.488		NA											3	137					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	241032090	241032090	+	Silent	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:241032090T>A	uc001hyv.2	-	8	843	c.513A>T	c.(511-513)GCA>GCT	p.A171A	RGS7_uc010pyh.1_Silent_p.A145A|RGS7_uc010pyj.1_Silent_p.A87A|RGS7_uc001hyu.2_Silent_p.A171A|RGS7_uc009xgn.1_Silent_p.A118A|RGS7_uc001hyw.2_Silent_p.A171A|RGS7_uc001hyt.2_Silent_p.A3A	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	171					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CTTGTGCTTCTGCTTGCATGA	0.448		NA											12	145					0	0	0	0
GATA3	2625	broad.mit.edu	37	10	8097767	8097767	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:8097767T>A	uc001ika.2	+	2	706	c.149T>A	c.(148-150)CTT>CAT	p.L50H	FLJ45983_uc010qbe.1_5'Flank|FLJ45983_uc001ijx.1_5'Flank|FLJ45983_uc010qbf.1_5'Flank|FLJ45983_uc010qbg.1_5'Flank|FLJ45983_uc001ijy.1_5'Flank|GATA3_uc001ijz.2_Missense_Mutation_p.L50H	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	50					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						GTGGATGTGCTTTTTAACATC	0.657		NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						6	3					0	0	0	0
ERCC6	2074	broad.mit.edu	37	10	50678456	50678456	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:50678456T>C	uc001jhs.3	-	18	3704	c.3550A>G	c.(3550-3552)AAA>GAA	p.K1184E	ERCC6_uc009xod.2_Missense_Mutation_p.K344E|ERCC6_uc010qgr.1_Missense_Mutation_p.K554E|ERCC6_uc001jhr.3_Missense_Mutation_p.K552E	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1184					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGTTTTGTTTTTGACTTGTGC	0.388		NA						Direct_reversal_of_damage|NER					68	100					0	0	0	0
MYST4	23522	broad.mit.edu	37	10	76789017	76789017	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:76789017G>A	uc001jwn.1	+	18	4928	c.4435G>A	c.(4435-4437)GTC>ATC	p.V1479I	MYST4_uc001jwo.1_Missense_Mutation_p.V1187I|MYST4_uc001jwp.1_Missense_Mutation_p.V1296I	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1479					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GGACTGTGGCGTCGACCTGAC	0.527		NA	T	CREBBP	AML								16	36					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95931086	95931086	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:95931086C>G	uc001kjk.2	+	4	2276	c.1642C>G	c.(1642-1644)CGC>GGC	p.R548G	PLCE1_uc010qnx.1_Missense_Mutation_p.R548G|PLCE1_uc001kjm.2_Missense_Mutation_p.R240G	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	548	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GACTATTTACCGCAGGGTCTT	0.547		NA											57	121					0	0	0	0
SEC31B	25956	broad.mit.edu	37	10	102247816	102247816	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:102247816C>A	uc001krc.1	-	25	3430	c.3328G>T	c.(3328-3330)GAG>TAG	p.E1110*	SEC31B_uc010qpo.1_Nonsense_Mutation_p.E1109*|SEC31B_uc001krd.1_Nonsense_Mutation_p.E647*|SEC31B_uc001krf.1_Nonsense_Mutation_p.E543*|SEC31B_uc001kre.1_Nonsense_Mutation_p.E541*	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1110					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TATAGATACTCCAGACGCTGG	0.527		NA											11	21					6.4e-05	7.19e-05	1	0
ZDHHC6	64429	broad.mit.edu	37	10	114194142	114194142	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:114194142A>T	uc001kzv.2	-	7	1240	c.816T>A	c.(814-816)TTT>TTA	p.F272L	ZDHHC6_uc001kzw.2_Missense_Mutation_p.F268L|ZDHHC6_uc009xya.1_Missense_Mutation_p.F272L	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	272						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		ATACCTGTTTAAAGTTCCTCC	0.398		NA											5	60					0	0	0	0
HABP2	3026	broad.mit.edu	37	10	115341746	115341746	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:115341746G>A	uc001lai.3	+	9	1053	c.950G>A	c.(949-951)GGC>GAC	p.G317D	HABP2_uc010qrz.1_Intron	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	317	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		ATCTATGGAGGCTTTAAGAGC	0.587		NA											7	97					0	0	0	0
EIF3A	8661	broad.mit.edu	37	10	120802159	120802159	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:120802159G>T	uc001ldu.2	-	19	3019	c.2873C>A	c.(2872-2874)CCC>CAC	p.P958H	EIF3A_uc010qsu.1_Missense_Mutation_p.P924H|EIF3A_uc009xzg.1_5'UTR	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	958	4.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GCCACGCCGGGGAACCCGATC	0.582		NA											46	118					4.22e-32	5.48e-32	1	0
BAG3	9531	broad.mit.edu	37	10	121436667	121436667	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:121436667A>G	uc001lem.2	+	4	1907	c.1601A>G	c.(1600-1602)AAG>AGG	p.K534R	BAG3_uc001lel.2_Missense_Mutation_p.K533R	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	534					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		GCAGCAGACAAGGGCAAGAAA	0.552		NA											23	67					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1256320	1256320	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:1256320G>A	uc009ycr.1	+	38	4739	c.4613G>A	c.(4612-4614)TGC>TAC	p.C1538Y	MUC5B_uc009yct.1_Missense_Mutation_p.C879Y|MUC5B_uc001ltb.2_Missense_Mutation_p.C882Y|MUC5B_uc001lta.2_Missense_Mutation_p.C547Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	879	VWFC 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGCAGCACCTGCAGGAACCGG	0.677		NA											10	16					0	0	0	0
ILK	3611	broad.mit.edu	37	11	6631495	6631495	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:6631495G>C	uc001mee.2	+	12	1330	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	ILK_uc001mef.2_Missense_Mutation_p.E399Q|ILK_uc010rap.1_Missense_Mutation_p.E265Q|ILK_uc010raq.1_Missense_Mutation_p.E338Q|ILK_uc001meg.2_Missense_Mutation_p.E245Q|ILK_uc001meh.2_Missense_Mutation_p.E399Q|ILK_uc001mei.2_Missense_Mutation_p.E25Q	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	399	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		CTCCAATATGGAGATTGGAAT	0.488		NA											24	30					0	0	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077367	19077367	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:19077367A>C	uc001mph.2	-	2	671	c.583T>G	c.(583-585)TTC>GTC	p.F195V		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	195	Helical; Name=5; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						AGAACCATGAATAAAAAAATC	0.512		NA											18	13					0	0	0	0
OR5M9	390162	broad.mit.edu	37	11	56230584	56230584	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:56230584C>A	uc010rjj.1	-	1	294	c.294G>T	c.(292-294)CAG>CAT	p.Q98H		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	98	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					AAAAGTAGCACTGCACCAAGC	0.488		NA											32	59					9.65e-13	1.19e-12	1	0
SLC22A9	114571	broad.mit.edu	37	11	63137735	63137735	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:63137735A>T	uc001nww.2	+	1	475	c.207A>T	c.(205-207)CAA>CAT	p.Q69H	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	69	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						CCCTCAGCCAAGATGCACTCT	0.527		NA											26	102					0	0	0	0
ACY3	91703	broad.mit.edu	37	11	67412541	67412541	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:67412541C>T	uc001omq.2	-	6	780	c.609G>A	c.(607-609)CTG>CTA	p.L203L		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	203					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	CGATGAAGTCCAGAACTGTGG	0.617		NA											58	116					0	0	0	0
OR8G2	26492	broad.mit.edu	37	11	124096301	124096301	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:124096301T>A	uc010saf.1	+	1	904	c.904T>A	c.(904-906)TCT>ACT	p.S302T		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	302						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GAACCCCCAATCTATAGCCTA	0.418		NA											6	112					0	0	0	0
CACNA1C	775	broad.mit.edu	37	12	2760859	2760859	+	Silent	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:2760859C>A	uc009zdu.1	+	34	4456	c.4143C>A	c.(4141-4143)GTC>GTA	p.V1381V	CACNA1C_uc009zdv.1_Silent_p.V1330V|CACNA1C_uc001qkb.2_Silent_p.V1333V|CACNA1C_uc001qkc.2_Silent_p.V1333V|CACNA1C_uc001qke.2_Silent_p.V1322V|CACNA1C_uc001qkf.2_Silent_p.V1322V|CACNA1C_uc001qjz.2_Silent_p.V1333V|CACNA1C_uc001qkd.2_Silent_p.V1333V|CACNA1C_uc001qkg.2_Silent_p.V1320V|CACNA1C_uc009zdw.1_Silent_p.V1355V|CACNA1C_uc001qkh.2_Silent_p.V1322V|CACNA1C_uc001qkl.2_Silent_p.V1381V|CACNA1C_uc001qkn.2_Silent_p.V1333V|CACNA1C_uc001qko.2_Silent_p.V1353V|CACNA1C_uc001qkp.2_Silent_p.V1333V|CACNA1C_uc001qkr.2_Silent_p.V1350V|CACNA1C_uc001qku.2_Silent_p.V1333V|CACNA1C_uc001qkq.2_Silent_p.V1361V|CACNA1C_uc001qks.2_Silent_p.V1333V|CACNA1C_uc001qkt.2_Silent_p.V1333V|CACNA1C_uc001qki.1_Silent_p.V1069V|CACNA1C_uc001qkj.1_Silent_p.V1069V|CACNA1C_uc001qkk.1_Silent_p.V1069V|CACNA1C_uc001qkm.1_Silent_p.V1058V|CACNA1C_uc010sea.1_Silent_p.V24V	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1381	Helical; Name=S4 of repeat IV; (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGTTCCGGGTCATGCGTCTGG	0.617		NA											33	57					3.9e-15	4.91e-15	1	0
PRMT8	56341	broad.mit.edu	37	12	3686072	3686072	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:3686072A>G	uc001qmf.2	+	7	1115	c.748A>G	c.(748-750)ATC>GTC	p.I250V	PRMT8_uc009zed.2_Missense_Mutation_p.I241V|PRMT8_uc009zee.1_RNA|PRMT8_uc001qmg.2_Missense_Mutation_p.I64V	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	250					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	p.I250M(1)		ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CATGACCTGCATCCGGGACGT	0.572		NA											16	264					0	0	0	0
A2ML1	144568	broad.mit.edu	37	12	9020506	9020506	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:9020506C>G	uc001quz.3	+	30	3884	c.3786C>G	c.(3784-3786)ATC>ATG	p.I1262M	A2ML1_uc001qva.1_Missense_Mutation_p.I842M|A2ML1_uc010sgm.1_Missense_Mutation_p.I762M|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1106						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						CTGAGGAGATCAACCTGGTTG	0.453		NA											33	44					0	0	0	0
GSG1	83445	broad.mit.edu	37	12	13238169	13238169	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:13238169C>A	uc001rbn.2	-	7	928	c.755G>T	c.(754-756)TGG>TTG	p.W252L	GSG1_uc001rbj.2_Missense_Mutation_p.W216L|GSG1_uc001rbk.2_Silent_p.L257L|GSG1_uc001rbl.2_Missense_Mutation_p.W188L|GSG1_uc001rbm.2_Missense_Mutation_p.W165L|GSG1_uc001rbo.2_Silent_p.L293L|GSG1_uc001rbp.2_Missense_Mutation_p.W229L|GSG1_uc001rbq.1_Silent_p.L293L	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	239	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GAAGGAGAGCCAGGCCATGCT	0.483		NA											13	35					2.27e-07	2.68e-07	1	0
LASS5	91012	broad.mit.edu	37	12	50535844	50535844	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:50535844G>A	uc001rwd.3	-	4	501	c.484C>T	c.(484-486)CTC>TTC	p.L162F	LASS5_uc001rwc.2_Missense_Mutation_p.L81F|LASS5_uc001rwe.3_Missense_Mutation_p.L103F|LASS5_uc001rwf.3_Intron|LASS5_uc010smq.1_Missense_Mutation_p.L18F	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	162	TLC.|Helical; (Potential).				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						ACCGACCAGAGAAATCTAATT	0.363		NA											11	15					0	0	0	0
POU6F1	5463	broad.mit.edu	37	12	51590624	51590624	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:51590624C>T	uc001rxy.2	-	1	195	c.3G>A	c.(1-3)ATG>ATA	p.M1I	POU6F1_uc001rxz.2_Missense_Mutation_p.M1I|POU6F1_uc001rya.2_Missense_Mutation_p.M1I	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	1	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGATCCCTGGCATGCTGGGAA	0.612		NA											6	84					0	0	0	0
MAP3K12	7786	broad.mit.edu	37	12	53878059	53878059	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:53878059C>T	uc001sdm.1	-	8	1229	c.1131G>A	c.(1129-1131)GAG>GAA	p.E377E	MAP3K12_uc001sdn.1_Silent_p.E410E	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	377					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						TAAAGTAAGTCTCCTGGGGTG	0.488		NA											11	31					0	0	0	0
EEA1	8411	broad.mit.edu	37	12	93196253	93196253	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:93196253G>C	uc001tck.2	-	19	2862	c.2597C>G	c.(2596-2598)TCT>TGT	p.S866C		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	866	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						CAAAGAATCAGAAACTTTTGA	0.308		NA											8	16					0	0	0	0
GNPTAB	79158	broad.mit.edu	37	12	102155370	102155370	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:102155370G>C	uc001tit.2	-	14	3066	c.2887C>G	c.(2887-2889)CGG>GGG	p.R963G		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	963					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						ATAACAATCCGGTCAATCATG	0.388		NA											24	38					0	0	0	0
SLC41A2	84102	broad.mit.edu	37	12	105282861	105282861	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:105282861A>T	uc001tla.2	-	4	997	c.830T>A	c.(829-831)CTT>CAT	p.L277H		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	277	Cytoplasmic.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						AGAGCACAGAAGTATGGAATG	0.398		NA											18	43					0	0	0	0
RNF10	9921	broad.mit.edu	37	12	121013686	121013686	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:121013686C>T	uc001typ.3	+	16	2775	c.2292C>T	c.(2290-2292)TCC>TCT	p.S764S	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.S675S	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	764					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCAAAATTCCTTCAGCCAAG	0.478		NA											93	136					0	0	0	0
TMEM120B	144404	broad.mit.edu	37	12	122181639	122181639	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:122181639G>A	uc001ubc.3	+	2	318	c.174G>A	c.(172-174)AAG>AAA	p.K58K	TMEM120B_uc009zxh.2_Silent_p.K58K	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	58	Potential.					integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		AGGACTTGAAGCTTACACTCC	0.418		NA											32	43					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123782584	123782584	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:123782584C>T	uc010tap.1	-	30	3980	c.3980G>A	c.(3979-3981)GGC>GAC	p.G1327D	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.G1326D|SBNO1_uc010taq.1_Missense_Mutation_p.G278D	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1327							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CACGTTTGTGCCACTGACAGA	0.428		NA											5	108					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124377980	124377980	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:124377980C>T	uc001uft.3	+	52	8867	c.8842C>T	c.(8842-8844)CCA>TCA	p.P2948S		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2948	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGAAACTTCCCAGGTACCCG	0.572		NA											30	55					0	0	0	0
USP12	219333	broad.mit.edu	37	13	27649390	27649390	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:27649390T>C	uc001uqy.2	-	7	1123	c.870A>G	c.(868-870)TCA>TCG	p.S290S		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	290					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TGGCATCACCTGAAGTGTTAA	0.408		NA											17	48					0	0	0	0
POSTN	10631	broad.mit.edu	37	13	38160349	38160349	+	Silent	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:38160349G>T	uc001uwo.3	-	7	940	c.822C>A	c.(820-822)CCC>CCA	p.P274P	POSTN_uc001uwp.3_Silent_p.P274P|POSTN_uc001uwr.2_Silent_p.P274P|POSTN_uc001uwq.2_Silent_p.P274P|POSTN_uc010teu.1_Silent_p.P274P|POSTN_uc010tev.1_Silent_p.P274P|POSTN_uc010tew.1_Silent_p.P274P|POSTN_uc010tex.1_Silent_p.P189P	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	274	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CCTCATTGGTGGGAGCAAAGA	0.468		NA											19	54					8.28e-16	1.05e-15	1	0
C13orf23	80209	broad.mit.edu	37	13	39588614	39588614	+	Splice_Site	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:39588614C>G	uc001uwy.2	-	11	1649	c.776_splice	c.e11-1	p.T259_splice	C13orf23_uc001uwz.2_Splice_Site_p.T237_splice	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1											ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GTGGAAAATGCTATATGGAAG	0.388		NA											8	23					0	0	0	0
NAA16	79612	broad.mit.edu	37	13	41891057	41891057	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:41891057G>T	uc001uyf.2	+	2	454	c.130G>T	c.(130-132)GAA>TAA	p.E44*	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Nonsense_Mutation_p.E44*|NAA16_uc001uyd.3_Nonsense_Mutation_p.E44*	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	44					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						AAAATTTGCTGAACATGGAGG	0.368		NA											8	18					7.48e-07	8.77e-07	1	0
CDC16	8881	broad.mit.edu	37	13	115002175	115002175	+	Splice_Site	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:115002175G>T	uc001vuk.1	+	2	301	c.103_splice	c.e2+1	p.E35_splice	CDC16_uc010tkm.1_Splice_Site_p.E35_splice|CDC16_uc001vul.1_Splice_Site_p.E35_splice|CDC16_uc001vum.1_Splice_Site|CDC16_uc001vun.1_Splice_Site_p.E35_splice|CDC16_uc001vuo.1_Splice_Site_p.E35_splice	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			CTCTCTCGTGGTAAGTGACAA	0.358		NA											21	50					3.88e-16	4.93e-16	1	0
PABPN1	8106	broad.mit.edu	37	14	23777304	23777304	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:23777304A>C	uc001wjh.3	+	3	516	c.328A>C	c.(328-330)AGT>CGT	p.S110R	BCL2L2_uc001wjg.3_Missense_Mutation_p.S110R|BCL2L2_uc001wji.3_Missense_Mutation_p.S110R	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	Error:Variant_position_missing_in_Q86U42_after_alignment					modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTGTGCTGAGAGTGTCAACAA	0.582		NA											39	50					0	0	0	0
NYNRIN	57523	broad.mit.edu	37	14	24880367	24880367	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:24880367G>T	uc001wpf.3	+	5	2818	c.2500G>T	c.(2500-2502)GTG>TTG	p.V834L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	834					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGAGGTCACTGTGTTTGTACC	0.592		NA									OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	65					3.77e-38	4.93e-38	1	0
AKAP6	9472	broad.mit.edu	37	14	33015409	33015409	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:33015409C>T	uc001wrq.2	+	4	1720	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	AKAP6_uc010aml.2_Missense_Mutation_p.S514L	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	517					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGGACTGGTTCAGGCAAACAA	0.463		NA											29	49					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44975866	44975866	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:44975866G>T	uc001wvn.2	-	1	634	c.325C>A	c.(325-327)CCA>ACA	p.P109T		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	109						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ACACTCTCTGGCAATTCAATA	0.418		NA											45	97					2.36e-20	3.03e-20	1	0
C14orf159	80017	broad.mit.edu	37	14	91642340	91642340	+	Missense_Mutation	SNP	G	G	T	rs75931548	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:91642340G>T	uc001xzb.2	+	9	1423	c.655G>T	c.(655-657)GGG>TGG	p.G219W	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Missense_Mutation_p.G224W|C14orf159_uc001xyx.2_Missense_Mutation_p.G207W|C14orf159_uc001xyw.2_Missense_Mutation_p.G224W|C14orf159_uc001xzc.2_Missense_Mutation_p.G219W|C14orf159_uc001xza.2_Missense_Mutation_p.G224W|C14orf159_uc001xyv.2_Missense_Mutation_p.G224W|C14orf159_uc001xyz.2_Missense_Mutation_p.G95W|C14orf159_uc001xze.2_Missense_Mutation_p.G219W	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	219						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GTGTCCCCCAGGGGAGGTTCC	0.537		NA											26	45					4.43e-23	5.72e-23	1	0
OR4N4	283694	broad.mit.edu	37	15	22383155	22383155	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:22383155C>A	uc001yuc.1	+	7	1664	c.683C>A	c.(682-684)GCA>GAA	p.A228E	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.A228E	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTTCGTAGGGCAGCTTCTGAA	0.493		NA											37	324					9.81e-26	1.27e-25	1	0
SPG11	80208	broad.mit.edu	37	15	44941138	44941138	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:44941138T>A	uc001ztx.2	-	7	1559	c.1528A>T	c.(1528-1530)AGT>TGT	p.S510C	SPG11_uc010ueh.1_Missense_Mutation_p.S510C|SPG11_uc010uei.1_Missense_Mutation_p.S510C|SPG11_uc001zua.1_Missense_Mutation_p.S510C	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	510	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GTGCTGGCACTTCCATGGATC	0.398		NA											14	42					0	0	0	0
LINGO1	84894	broad.mit.edu	37	15	77907870	77907870	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:77907870G>A	uc002bct.1	-	2	431	c.379C>T	c.(379-381)CGC>TGC	p.R127C	LINGO1_uc002bcu.1_Missense_Mutation_p.R121C	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	127	Extracellular (Potential).|LRR 3.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						CGGTTGCTGCGGAGACCCAGC	0.602		NA											13	25					0	0	0	0
CHRNA3	1136	broad.mit.edu	37	15	78894291	78894291	+	Silent	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:78894291G>T	uc002bec.2	-	5	879	c.693C>A	c.(691-693)ATC>ATA	p.I231I	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Silent_p.I231I	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	231	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						GCGAGTATGTGATGTCGGGGT	0.547		NA											22	29					9.96e-16	1.26e-15	1	0
KIAA1199	57214	broad.mit.edu	37	15	81225737	81225737	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:81225737G>A	uc002bfw.1	+	22	3205	c.2945G>A	c.(2944-2946)CGG>CAG	p.R982Q	KIAA1199_uc010unn.1_Missense_Mutation_p.R982Q	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	982										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGGCTGGTCCGGCACCCAGAC	0.582		NA											29	70					0	0	0	0
TRAP1	10131	broad.mit.edu	37	16	3722789	3722789	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:3722789C>T	uc002cvt.3	-	10	1166	c.1077G>A	c.(1075-1077)CTG>CTA	p.L359L	TRAP1_uc002cvs.2_Silent_p.L150L|TRAP1_uc010uxf.1_Silent_p.L306L	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	359					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				CGCTGGAGCCCAGCTCCCGGC	0.622		NA											5	12					0	0	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31485728	31485728	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:31485728G>T	uc002ecd.1	+	6	497	c.471G>T	c.(469-471)GAG>GAT	p.E157D	TGFB1I1_uc002ece.1_Missense_Mutation_p.E140D|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	157	Transcription activation (By similarity).|LD motif 3.|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CCACTCTGGAGCTGGATAGAC	0.572		NA											14	81					2.32e-09	2.81e-09	1	0
CNGB1	1258	broad.mit.edu	37	16	57994742	57994742	+	Splice_Site	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:57994742A>G	uc002emt.2	-	8	599	c.534_splice	c.e8+1	p.E178_splice	CNGB1_uc010cdh.2_Splice_Site_p.E178_splice|CNGB1_uc002emu.2_Splice_Site_p.E178_splice	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform						sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TCCTTGGCTCACCTCAGAGGA	0.642		NA											14	30					0	0	0	0
CNOT1	23019	broad.mit.edu	37	16	58572083	58572083	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:58572083C>T	uc002env.2	-	37	5516	c.5223G>A	c.(5221-5223)CAG>CAA	p.Q1741Q	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.Q1736Q|CNOT1_uc010vik.1_Silent_p.Q698Q	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1741					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GAAGATCATACTGCTGCATAT	0.403		NA											7	23					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65038544	65038544	+	Splice_Site	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:65038544C>A	uc002eoi.2	-	3	662	c.228_splice	c.e3+1	p.R76_splice	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Splice_Site_p.R76_splice|CDH11_uc010vin.1_Intron|CDH11_uc010vio.1_Splice_Site_p.R76_splice	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GGCAGCCTTACCCTGCCCACA	0.572		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	16					9.77e-05	0.000108959	1	0
CTCF	10664	broad.mit.edu	37	16	67650762	67650762	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:67650762G>T	uc002etl.2	+	5	1357	c.1067G>T	c.(1066-1068)TGC>TTC	p.C356F	CTCF_uc010cek.2_Missense_Mutation_p.C28F	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	356	C2H2-type 4.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TGTTCCATGTGCGATTACGCC	0.448		NA											80	130					1.07e-64	1.41e-64	1	0
ESRP2	80004	broad.mit.edu	37	16	68265188	68265188	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:68265188T>A	uc010cfa.1	-	12	1822	c.1634A>T	c.(1633-1635)GAG>GTG	p.E545V	ESRP2_uc002evp.1_Intron|ESRP2_uc002evq.1_Missense_Mutation_p.E535V	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	545	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						CACGTAGCGCTCCTTCATCAC	0.617		NA											21	39					0	0	0	0
OVCA2	124641	broad.mit.edu	37	17	1945365	1945365	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:1945365G>A	uc002ftx.2	+	1	89	c.24G>A	c.(22-24)CGG>CGA	p.R8R	DPH1_uc002ftr.1_Intron|DPH1_uc002fts.2_Intron|DPH1_uc002ftt.2_Intron|DPH1_uc010cjx.2_Intron|DPH1_uc010vqs.1_Intron|DPH1_uc002ftu.2_Intron|DPH1_uc002ftv.2_Intron|DPH1_uc002ftw.2_3'UTR	NM_080822	NP_543012	Q8WZ82	OVCA2_HUMAN	candidate tumor suppressor in ovarian cancer 2	8					response to retinoic acid	cytoplasm	hydrolase activity				0						GACCCCTGCGGGTCCTGTGCC	0.716		NA									OREG0024078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	4					0	0	0	0
TRPV3	162514	broad.mit.edu	37	17	3419860	3419860	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:3419860C>T	uc002fvt.1	-	16	2411	c.2089G>A	c.(2089-2091)GCC>ACC	p.A697T	SPATA22_uc010vrg.1_5'Flank|TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.A681T|TRPV3_uc010vri.1_Missense_Mutation_p.A652T|TRPV3_uc010vrj.1_Missense_Mutation_p.A681T|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.A681T|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.A697T|TRPV3_uc002fvu.2_Missense_Mutation_p.A697T	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	697	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	ATGGTCCTGGCTCTCTGGGGA	0.537		NA											13	12					0	0	0	0
ZZEF1	23140	broad.mit.edu	37	17	3977538	3977538	+	Silent	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:3977538A>G	uc002fxe.2	-	24	3655	c.3591T>C	c.(3589-3591)GAT>GAC	p.D1197D		NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1197							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACACGGCAACATCGGGCAGCC	0.587		NA									OREG0024096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	84	70					0	0	0	0
ZNF232	7775	broad.mit.edu	37	17	5009729	5009729	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:5009729G>T	uc002gas.2	-	5	1398	c.644C>A	c.(643-645)TCA>TAA	p.S215*	ZNF232_uc002gar.1_Nonsense_Mutation_p.S233*|ZNF232_uc002gat.2_Nonsense_Mutation_p.S242*	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	215					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GAACACCTGTGATTCCACTTC	0.448		NA											30	14					1.4e-14	1.75e-14	1	0
TP53	7157	broad.mit.edu	37	17	7577126	7577126	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:7577126T>A	uc002gim.2	-	8	1006	c.812A>T	c.(811-813)GAG>GTG	p.E271V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139V|TP53_uc010cng.1_Missense_Mutation_p.E139V|TP53_uc002gii.1_Missense_Mutation_p.E139V|TP53_uc010cnh.1_Missense_Mutation_p.E271V|TP53_uc010cni.1_Missense_Mutation_p.E271V|TP53_uc002gij.2_Missense_Mutation_p.E271V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACACGCACCTCAAAGCTGTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	9					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11554533	11554533	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:11554533G>T	uc002gne.2	+	13	2313	c.2245G>T	c.(2245-2247)GTT>TTT	p.V749F	DNAH9_uc010coo.2_Missense_Mutation_p.V43F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	749	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTACAACAAGGTTATGAAAAC	0.463		NA											5	69					0.00116845	0.00127074	1	0
MYO15A	51168	broad.mit.edu	37	17	18075505	18075505	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:18075505C>T	uc010vxh.1	+	63	10589	c.10251C>T	c.(10249-10251)TCC>TCT	p.S3417S	MYO15A_uc010vxi.1_Silent_p.S681S|MYO15A_uc010vxk.1_Silent_p.S110S|MYO15A_uc010vxl.1_Silent_p.S406S|MYO15A_uc002gsl.2_Intron|MYO15A_uc010vxm.1_Missense_Mutation_p.P241L|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3417	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TCGGCTCCTCCTTCTTCTTCA	0.582		NA											4	33					0	0	0	0
MYO18A	399687	broad.mit.edu	37	17	27426719	27426719	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:27426719C>T	uc002hdt.1	-	22	3727	c.3569G>A	c.(3568-3570)AGG>AAG	p.R1190K	MYO18A_uc010wbc.1_Missense_Mutation_p.R732K|MYO18A_uc002hds.2_Missense_Mutation_p.R732K|MYO18A_uc010csa.1_Missense_Mutation_p.R1190K|MYO18A_uc002hdu.1_Missense_Mutation_p.R1190K|MYO18A_uc010wbd.1_Missense_Mutation_p.R859K	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1190	IQ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGTTAGGTTCCTGCTGGTTTG	0.607		NA											12	29					0	0	0	0
TAOK1	57551	broad.mit.edu	37	17	27857580	27857580	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:27857580A>T	uc002hdz.1	+	18	2498	c.2304A>T	c.(2302-2304)TTA>TTT	p.L768F	TAOK1_uc010wbe.1_Missense_Mutation_p.L620F|TAOK1_uc010wbf.1_Missense_Mutation_p.L768F	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	768	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			CCCGGAAATTAGCTATCTTGG	0.443		NA											28	37					0	0	0	0
ACCN1	40	broad.mit.edu	37	17	32483076	32483076	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:32483076C>T	uc002hhu.2	-	1	750	c.476G>A	c.(475-477)CGT>CAT	p.R159H		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	159	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	ATGGCCCACACGGTGCAGGAA	0.562		NA											39	74					0	0	0	0
MAPT	4137	broad.mit.edu	37	17	44096055	44096055	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:44096055C>A	uc002ijr.3	+	13	2340	c.2020C>A	c.(2020-2022)CTG>ATG	p.L674M	MAPT_uc010dau.2_Missense_Mutation_p.L692M|MAPT_uc002ijs.3_Missense_Mutation_p.L357M|MAPT_uc002ijx.3_Missense_Mutation_p.L328M|MAPT_uc002ijt.3_Missense_Mutation_p.L299M|MAPT_uc002iju.3_Missense_Mutation_p.L268M|MAPT_uc002ijv.3_Missense_Mutation_p.L275M	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	674	Tau/MAP 4.				cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GATTGGGTCCCTGGACAATAT	0.493		NA											6	186					3.6e-05	4.09e-05	1	0
ACSF2	80221	broad.mit.edu	37	17	48548429	48548429	+	Missense_Mutation	SNP	C	C	T	rs148600715		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:48548429C>T	uc002iqu.2	+	11	1360	c.1256C>T	c.(1255-1257)GCG>GTG	p.A419V	ACSF2_uc010wml.1_Missense_Mutation_p.A376V|ACSF2_uc010wmm.1_Missense_Mutation_p.A444V|ACSF2_uc010wmn.1_Missense_Mutation_p.A406V|ACSF2_uc010wmo.1_Missense_Mutation_p.A259V|CHAD_uc010dbr.2_5'Flank|CHAD_uc010dbs.2_5'Flank|ACSF2_uc010dbt.1_5'UTR	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	419					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GTGACATTCGCGCACTTCCCT	0.562		NA											33	54					0	0	0	0
CACNA1G	8913	broad.mit.edu	37	17	48694921	48694921	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:48694921G>C	uc002irk.1	+	29	5516	c.5144G>C	c.(5143-5145)CGC>CCC	p.R1715P	CACNA1G_uc002irj.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irl.1_Missense_Mutation_p.R1692P|CACNA1G_uc002irm.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irn.1_Missense_Mutation_p.R1674P|CACNA1G_uc002iro.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irp.1_Missense_Mutation_p.R1715P|CACNA1G_uc002irq.1_Missense_Mutation_p.R1692P|CACNA1G_uc002irr.1_Missense_Mutation_p.R1715P|CACNA1G_uc002irs.1_Missense_Mutation_p.R1704P|CACNA1G_uc002irt.1_Missense_Mutation_p.R1697P|CACNA1G_uc002irv.1_Missense_Mutation_p.R1704P|CACNA1G_uc002irw.1_Missense_Mutation_p.R1692P|CACNA1G_uc002iru.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irx.1_Missense_Mutation_p.R1628P|CACNA1G_uc002iry.1_Missense_Mutation_p.R1617P|CACNA1G_uc002irz.1_Missense_Mutation_p.R1628P|CACNA1G_uc002isa.1_Missense_Mutation_p.R1594P|CACNA1G_uc002isb.1_Missense_Mutation_p.R1635P|CACNA1G_uc002isc.1_Missense_Mutation_p.R1617P|CACNA1G_uc002isd.1_Missense_Mutation_p.R1610P|CACNA1G_uc002ise.1_Missense_Mutation_p.R1583P|CACNA1G_uc002isf.1_Missense_Mutation_p.R1610P|CACNA1G_uc002isg.1_Missense_Mutation_p.R1576P|CACNA1G_uc002ish.1_Missense_Mutation_p.R1583P|CACNA1G_uc002isi.1_Missense_Mutation_p.R1571P	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1715	IV.|Helical; Name=S4 of repeat IV; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGGGTGCTGCGCATTGCCCGA	0.622		NA											12	81					0	0	0	0
MPO	4353	broad.mit.edu	37	17	56355336	56355336	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:56355336G>T	uc002ivu.1	-	7	1233	c.1056C>A	c.(1054-1056)AAC>AAA	p.N352K		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	352					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	TGTTGCGCAGGTTCCTGGCCA	0.642		NA											26	78					1.43e-11	1.74e-11	1	0
KIAA0195	9772	broad.mit.edu	37	17	73485427	73485427	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:73485427A>G	uc002jnz.3	+	8	1120	c.845A>G	c.(844-846)CAC>CGC	p.H282R	KIAA0195_uc010wsa.1_Missense_Mutation_p.H292R|KIAA0195_uc010wsb.1_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	282	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTGATGCTACACTATGCTGTG	0.637		NA											10	68					0	0	0	0
C17orf101	79701	broad.mit.edu	37	17	80350347	80350348	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:80350347_80350348CC>AA	uc002keu.1	-	9	987_988	c.886_887GG>TT	c.(886-888)GGC>TTC	p.G296F	C17orf101_uc002ket.1_3'UTR|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	296	Fe2OG dioxygenase.|Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						GTAACGGGTGCCCCAGTGGACC	0.624		NA											5	21					0	0	0	0
CEP192	55125	broad.mit.edu	37	18	13057679	13057679	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr18:13057679C>T	uc010xac.1	+	20	4284	c.4204C>T	c.(4204-4206)CGC>TGC	p.R1402C	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.R927C|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Missense_Mutation_p.R1143C	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1402										ovary(4)|pancreas(1)	5						TCCAACTGACCGCTGGCTGCA	0.502		NA											48	13					0	0	0	0
PIAS2	9063	broad.mit.edu	37	18	44424058	44424058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr18:44424058C>A	uc002lck.2	-	8	1158	c.1000G>T	c.(1000-1002)GAA>TAA	p.E334*	PIAS2_uc010dnp.2_Nonsense_Mutation_p.E32*|PIAS2_uc002lcl.2_Nonsense_Mutation_p.E334*|PIAS2_uc010xda.1_Nonsense_Mutation_p.E32*|PIAS2_uc002lcm.2_Nonsense_Mutation_p.E334*|PIAS2_uc002lcn.1_Nonsense_Mutation_p.E338*	NM_004671	NP_004662	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT X isoform	334	SP-RING-type.				androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						GTAGCAATTTCACTATCAGGA	0.294		NA											24	23					5.62e-17	7.17e-17	1	0
MUC16	94025	broad.mit.edu	37	19	9082378	9082378	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:9082378C>G	uc002mkp.2	-	1	9641	c.9437G>C	c.(9436-9438)AGC>ACC	p.S3146T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3147	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAAATAGAGCTTGCCCATGT	0.473		NA											22	24					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11096928	11096928	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:11096928C>A	uc002mqf.3	+	4	703	c.419C>A	c.(418-420)TCT>TAT	p.S140Y	SMARCA4_uc010dxp.2_Missense_Mutation_p.S140Y|SMARCA4_uc010dxo.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqg.1_Missense_Mutation_p.S140Y|SMARCA4_uc010dxq.2_Missense_Mutation_p.S140Y|SMARCA4_uc010dxr.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqj.3_Missense_Mutation_p.S140Y|SMARCA4_uc010dxs.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqe.2_Missense_Mutation_p.S140Y	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	140	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGTGGCCCGTCTTCGGGGCCC	0.662		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				28	21					6.39e-12	7.85e-12	1	0
CYP4F11	57834	broad.mit.edu	37	19	16034706	16034706	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:16034706G>A	uc002nbu.2	-	7	870	c.834C>T	c.(832-834)CTC>CTT	p.L278L	CYP4F11_uc010eab.1_Silent_p.L278L|CYP4F11_uc002nbt.2_Silent_p.L278L	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	278					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CCTGAGTGGGGAGGGTGCAGC	0.542		NA											69	90					0	0	0	0
FAM129C	199786	broad.mit.edu	37	19	17654420	17654420	+	Missense_Mutation	SNP	C	C	A	rs10401716	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:17654420C>A	uc010xpr.1	+	13	1765	c.1627C>A	c.(1627-1629)CTC>ATC	p.L543I	FAM129C_uc010xpq.1_Missense_Mutation_p.L543I|FAM129C_uc002ngy.3_Missense_Mutation_p.L269I|FAM129C_uc010xpu.1_Missense_Mutation_p.L269I|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_Intron|FAM129C_uc002nhb.2_Missense_Mutation_p.L172I	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	543											0						GCTGAGCCAACTCGAGCCAGG	0.502		NA											3	23					0.004672	0.00500316	1	0
B3GNT3	10331	broad.mit.edu	37	19	17918965	17918965	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:17918965C>T	uc002nhk.1	+	2	434	c.349C>T	c.(349-351)CCT>TCT	p.P117S	B3GNT3_uc002nhl.1_Missense_Mutation_p.P117S|B3GNT3_uc010ebd.1_Missense_Mutation_p.P117S|B3GNT3_uc010ebe.1_Missense_Mutation_p.P117S	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	117	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CAAGTCCTCCCCTAGCAACTA	0.667		NA											9	32					0	0	0	0
SFRS14	10147	broad.mit.edu	37	19	19130026	19130026	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:19130026C>T	uc002nkx.2	-	4	1888	c.1742G>A	c.(1741-1743)CGA>CAA	p.R581Q	SFRS14_uc002nkz.1_Missense_Mutation_p.R595Q|SFRS14_uc002nla.1_Missense_Mutation_p.R581Q|SFRS14_uc002nlb.2_Missense_Mutation_p.R581Q|SFRS14_uc010xqk.1_Missense_Mutation_p.R350Q	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	581					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			GTGATCTGCTCGCTGGGGGAC	0.522		NA											15	27					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363996	22363996	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:22363996C>A	uc002nqs.1	-	3	841	c.523G>T	c.(523-525)GGC>TGC	p.G175C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	175	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAAGCTTTGCCATTTTCTTCA	0.338		NA											25	33					8.25e-16	1.05e-15	1	0
ZNF536	9745	broad.mit.edu	37	19	30936598	30936598	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:30936598C>A	uc002nsu.1	+	2	2267	c.2129C>A	c.(2128-2130)GCC>GAC	p.A710D	ZNF536_uc010edd.1_Missense_Mutation_p.A710D	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACCGGGAGTGCCCAGGAGGAC	0.682		NA											4	60					0.00909568	0.00962971	1	0
ZFP14	57677	broad.mit.edu	37	19	36853054	36853054	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:36853054C>T	uc002odx.1	-	2	189	c.96G>A	c.(94-96)AGG>AGA	p.R32R	ZFP14_uc010xtd.1_Silent_p.R32R|ZFP14_uc010eex.1_Silent_p.R32R	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					ACATTACATCCCTATATAAGT	0.403		NA											8	48					0	0	0	0
ZFP36	7538	broad.mit.edu	37	19	39899199	39899199	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:39899199C>A	uc002olh.1	+	2	899	c.841C>A	c.(841-843)CCT>ACT	p.P281T	ZFP36_uc010egn.1_Silent_p.T153T	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	281					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGATCCGACCCTGATGAATA	0.667		NA											26	82					7.42e-09	8.96e-09	1	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627		NA											14	33					0	0	0	0
HIPK4	147746	broad.mit.edu	37	19	40886277	40886277	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:40886277G>A	uc002onp.2	-	3	1906	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	541						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TCCTCATCTCGCTGCAGGATG	0.622		NA											38	76					0	0	0	0
RCN3	57333	broad.mit.edu	37	19	50046458	50046458	+	Silent	SNP	C	C	T	rs149927163		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:50046458C>T	uc002poj.2	+	7	1422	c.975C>T	c.(973-975)CAC>CAT	p.H325H		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	325	Prevents secretion from ER (Potential).					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		CCCGGCACCACGATGAGCTGT	0.647		NA											10	27					0	0	0	0
PRR12	57479	broad.mit.edu	37	19	50105149	50105149	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:50105149C>T	uc002poo.3	+	6	4747	c.4747C>T	c.(4747-4749)CGT>TGT	p.R1583C		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	762							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GTTCGTCATCCGTGCTGAGGA	0.547		NA											4	32					0	0	0	0
CD33	945	broad.mit.edu	37	19	51728815	51728815	+	Missense_Mutation	SNP	T	T	C	rs146181856	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:51728815T>C	uc002pwa.2	+	2	419	c.379T>C	c.(379-381)TAC>CAC	p.Y127H	CD33_uc010eos.1_Missense_Mutation_p.Y127H|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	127	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AAGTACCAAATACAGTTACAA	0.532		NA											53	44					0	0	0	0
NLRP5	126206	broad.mit.edu	37	19	56539846	56539846	+	Silent	SNP	C	C	T	rs149649207	by1000genomes	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:56539846C>T	uc002qmj.2	+	7	2247	c.2247C>T	c.(2245-2247)TCC>TCT	p.S749S	NLRP5_uc002qmi.2_Silent_p.S730S	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	749	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAGATGAGTCCGCTGAGGCAT	0.517		NA											19	290					0	0	0	0
WDR35	57539	broad.mit.edu	37	2	20138033	20138033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:20138033G>A	uc002rdi.2	-	19	2197	c.2089C>T	c.(2089-2091)CGA>TGA	p.R697*	WDR35_uc002rdj.2_Nonsense_Mutation_p.R686*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.R262*|WDR35_uc002rdk.3_Nonsense_Mutation_p.R262*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	697										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACCAAAGTCGGGGGTGTGGA	0.438		NA											22	122					0	0	0	0
C2orf16	84226	broad.mit.edu	37	2	27804830	27804830	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:27804830C>A	uc002rkz.3	+	1	5442	c.5391C>A	c.(5389-5391)AGC>AGA	p.S1797R	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1797	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.|21.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTGAGAGAAGCCATCACAGTC	0.547		NA											23	322					8.53e-09	1.03e-08	1	0
YPEL5	51646	broad.mit.edu	37	2	30379615	30379615	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:30379615C>T	uc002rna.3	+	4	659	c.98C>T	c.(97-99)ACT>ATT	p.T33I	YPEL5_uc002rnb.3_Missense_Mutation_p.T33I|YPEL5_uc002rnc.3_Missense_Mutation_p.T33I|YPEL5_uc002rmz.3_Missense_Mutation_p.T33I|YPEL5_uc010ezn.2_Intron|YPEL5_uc002rnd.2_Missense_Mutation_p.T33I	NM_001127401	NP_001120873	P62699	YPEL5_HUMAN	yippee-like 5	33							peptide-methionine-(S)-S-oxide reductase activity				0	Acute lymphoblastic leukemia(172;0.155)					CTCATCTCCACTCGTTTCACA	0.438		NA											20	131					0	0	0	0
LRPPRC	10128	broad.mit.edu	37	2	44145429	44145429	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:44145429T>A	uc002rtr.2	-	28	3063	c.3005A>T	c.(3004-3006)GAG>GTG	p.E1002V	LRPPRC_uc010yob.1_Missense_Mutation_p.E902V	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1002					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTGGTTACCCTCTCTAAGGAT	0.368		NA											14	43					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56419698	56419698	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:56419698G>A	uc002rzn.2	+	2	865	c.363G>A	c.(361-363)AGG>AGA	p.R121R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	121										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAGGCAAGAGGGTGTCTCGGG	0.542		NA											18	60					0	0	0	0
APLF	200558	broad.mit.edu	37	2	68772424	68772424	+	Silent	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:68772424C>G	uc002sep.2	+	8	1439	c.1266C>G	c.(1264-1266)CCC>CCG	p.P422P	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Silent_p.P398P|APLF_uc002ser.1_Silent_p.P153P	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	422	PBZ-type 2.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						CTGAATGTCCCTATGGACCAT	0.423		NA											6	47					0	0	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86075251	86075251	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:86075251A>T	uc002sqq.1	-	4	524	c.395T>A	c.(394-396)TTA>TAA	p.L132*	ST3GAL5_uc010fgq.1_Nonsense_Mutation_p.L4*|ST3GAL5_uc002sqp.1_Nonsense_Mutation_p.L109*	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	132	Lumenal (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						GTGCTCAAATAACAGCGCCAT	0.483		NA											135	222					0	0	0	0
MYO7B	4648	broad.mit.edu	37	2	128394185	128394185	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:128394185C>T	uc002top.2	+	45	6164	c.6111C>T	c.(6109-6111)CTC>CTT	p.L2037L	MYO7B_uc002tos.1_Silent_p.L147L|MYO7B_uc002tot.2_Silent_p.L147L	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2037	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGGTTCTGCTCATCCACCCCA	0.652		NA											6	12					0	0	0	0
FAM123C	205147	broad.mit.edu	37	2	131521973	131521973	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:131521973G>A	uc002trw.2	+	2	2518	c.2328G>A	c.(2326-2328)CAG>CAA	p.Q776Q	FAM123C_uc010fmv.2_Silent_p.Q776Q|FAM123C_uc010fms.1_Silent_p.Q776Q|FAM123C_uc010fmt.1_Silent_p.Q776Q|FAM123C_uc010fmu.1_Silent_p.Q776Q	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	776										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGCCCTTGCAGCTCAGCACAG	0.677		NA											7	18					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141115638	141115638	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:141115638A>C	uc002tvj.1	-	74	12277	c.11305T>G	c.(11305-11307)TGT>GGT	p.C3769G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3769	Extracellular (Potential).|LDL-receptor class A 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTACTACAAGCAAACTCA	0.388		NA								TSP Lung(27;0.18)			26	45					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152520126	152520126	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:152520126T>C	uc010fnx.2	-	45	5890	c.5699A>G	c.(5698-5700)TAC>TGC	p.Y1900C		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1900	Nebulin 50.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAGCATGTTGTAGGTATGGAT	0.483		NA											8	35					0	0	0	0
TANC1	85461	broad.mit.edu	37	2	160028631	160028631	+	Splice_Site	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:160028631G>T	uc002uag.2	+	11	1626	c.1352_splice	c.e11-1	p.T451_splice	TANC1_uc010fol.1_Splice_Site_p.T345_splice|TANC1_uc010zcm.1_Splice_Site_p.T443_splice|TANC1_uc010fom.1_Splice_Site_p.T257_splice	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TTTCTCTGCAGCCTCTGACCC	0.438		NA											27	52					7.26e-15	9.1e-15	1	0
TTN	7273	broad.mit.edu	37	2	179604400	179604400	+	Silent	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:179604400A>G	uc010zfh.1	-	46	13271	c.13047T>C	c.(13045-13047)ACT>ACC	p.T4349T	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Silent_p.T4282T|TTN_uc010zfj.1_Silent_p.T4157T|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTGGTTCAGTAATGGGTT	0.393		NA											40	106					0	0	0	0
LOC200726	200726	broad.mit.edu	37	2	207509209	207509209	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:207509209G>A	uc010fuh.1	+	2	424	c.249G>A	c.(247-249)GAG>GAA	p.E83E		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		AGTCATCTGAGAACTTGAAGC	0.493		NA											10	25					0	0	0	0
XRCC5	7520	broad.mit.edu	37	2	217002844	217002844	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:217002844A>C	uc002vfy.2	+	12	1424	c.1284A>C	c.(1282-1284)GAA>GAC	p.E428D	XRCC5_uc002vfz.2_Missense_Mutation_p.E314D	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	428	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		CTTTCATGGAAGACTTGCGGC	0.368		NA						Direct_reversal_of_damage|NHEJ					11	15					0	0	0	0
OBSL1	23363	broad.mit.edu	37	2	220417282	220417282	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:220417282C>T	uc010fwk.2	-	18	5341	c.5284G>A	c.(5284-5286)GCC>ACC	p.A1762T		NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1762					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CGGACGCGGGCTCCGGGTCTC	0.731		NA											6	15					0	0	0	0
OBSL1	23363	broad.mit.edu	37	2	220424011	220424011	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:220424011C>T	uc010fwk.2	-	9	3219	c.3162G>A	c.(3160-3162)GAG>GAA	p.E1054E	OBSL1_uc002vmh.1_Silent_p.E45E|OBSL1_uc010zli.1_Silent_p.E45E|OBSL1_uc010fwl.1_Silent_p.E529E	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1054	Ig-like 8.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CGCCCCCGTCCTCGGGCTGAG	0.617		NA											31	109					0	0	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563937	228563937	+	Missense_Mutation	SNP	G	G	A	rs144223086	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:228563937G>A	uc002vpi.2	-	3	583	c.494C>T	c.(493-495)GCG>GTG	p.A165V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.A161V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	165	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CGACATGTTCGCCAGGGATAC	0.542		NA											48	90					0	0	0	0
ALPI	248	broad.mit.edu	37	2	233321697	233321697	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:233321697G>C	uc002vst.3	+	4	466	c.389G>C	c.(388-390)GGC>GCC	p.G130A	ALPI_uc002vsu.3_Missense_Mutation_p.G41A	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	130					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CAGACCATCGGCTTGAGTGCA	0.617		NA											3	34					0	0	0	0
SH3BP4	23677	broad.mit.edu	37	2	235949783	235949783	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:235949783A>G	uc002vvp.2	+	4	763	c.370A>G	c.(370-372)ATG>GTG	p.M124V	SH3BP4_uc010fym.2_Missense_Mutation_p.M124V|SH3BP4_uc002vvq.2_Missense_Mutation_p.M124V	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	124					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGACAGCGGTATGATTGATAA	0.527		NA											17	41					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241657475	241657475	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:241657475C>T	uc002vzy.2	-	46	5168	c.5022G>A	c.(5020-5022)GGG>GGA	p.G1674G	KIF1A_uc010fzk.2_Silent_p.G1775G|KIF1A_uc002vzw.2_Silent_p.G335G|KIF1A_uc002vzx.2_Silent_p.G401G	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1674					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACCGTATGGTCCCGGCCAGGA	0.667		NA											4	14					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9391725	9391725	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:9391725G>T	uc002wnf.2	+	23	2141	c.2005G>T	c.(2005-2007)GGA>TGA	p.G669*	PLCB4_uc010gbw.1_Nonsense_Mutation_p.G669*|PLCB4_uc010gbx.2_Nonsense_Mutation_p.G681*|PLCB4_uc002wne.2_Nonsense_Mutation_p.G669*|PLCB4_uc002wnh.2_Nonsense_Mutation_p.G516*	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	669	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TGAGTATAATGGATCGTGCGG	0.368		NA											12	35					7.04e-09	8.52e-09	1	0
KIF3B	9371	broad.mit.edu	37	20	30904034	30904034	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:30904034A>C	uc002wxq.2	+	3	1585	c.1418A>C	c.(1417-1419)AAG>ACG	p.K473T	KIF3B_uc010ztw.1_Missense_Mutation_p.K411T	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	473	Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGGAGAGTAAGTTGCTTGTT	0.408		NA											11	79					0	0	0	0
ZBP1	81030	broad.mit.edu	37	20	56189965	56189965	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:56189965T>C	uc002xyo.2	-	4	761	c.480A>G	c.(478-480)AAA>AAG	p.K160K	ZBP1_uc010gjm.2_Silent_p.K160K|ZBP1_uc002xyp.2_Silent_p.K85K|ZBP1_uc010zzn.1_Silent_p.K160K	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	160	DRADA 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TCGTCCATGCTTTGGACTGCT	0.557		NA											57	121					0	0	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744004	31744004	+	Nonstop_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr21:31744004T>A	uc002ynz.3	-	1	554	c.528A>T	c.(526-528)TGA>TGT	p.*176C		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	176						intermediate filament					0						GTCTGGAAATTCAGCAAGTTG	0.468		NA											4	53					0	0	0	0
XYLB	9942	broad.mit.edu	37	3	38442394	38442394	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:38442394G>A	uc003cic.2	+	18	1560	c.1451G>A	c.(1450-1452)GGA>GAA	p.G484E	XYLB_uc011ayp.1_Missense_Mutation_p.G347E|XYLB_uc003cid.1_Missense_Mutation_p.G406E	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	484					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		CTTGCAGGTGGAACAGATGTG	0.468		NA											22	21					0	0	0	0
AMIGO3	386724	broad.mit.edu	37	3	49756364	49756364	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:49756364C>T	uc003cxj.2	-	1	875	c.535G>A	c.(535-537)GGT>AGT	p.G179S	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	179	Extracellular (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCGCTCAGACCGTGCAGGTGG	0.642		NA									OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	29					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53842766	53842766	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:53842766C>T	uc003dgv.3	+	46	6003	c.5840C>T	c.(5839-5841)ACG>ATG	p.T1947M	CACNA1D_uc003dgu.3_Missense_Mutation_p.T1967M|CACNA1D_uc003dgy.3_Missense_Mutation_p.T1923M|CACNA1D_uc003dgw.3_Missense_Mutation_p.T1614M|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1947	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCCCATCGCACGGCCCTGCCT	0.642		NA											9	60					0	0	0	0
MBNL1	4154	broad.mit.edu	37	3	152163264	152163264	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:152163264A>C	uc003ezm.2	+	4	1532	c.743A>C	c.(742-744)AAG>ACG	p.K248T	MBNL1_uc003ezh.2_Missense_Mutation_p.K248T|MBNL1_uc003ezi.2_Missense_Mutation_p.K248T|MBNL1_uc003ezj.2_Missense_Mutation_p.K191T|MBNL1_uc003ezl.2_Missense_Mutation_p.K248T|MBNL1_uc003ezp.2_Missense_Mutation_p.K248T|MBNL1_uc003ezn.2_Missense_Mutation_p.K180T|MBNL1_uc003ezo.2_Missense_Mutation_p.K180T|MBNL1_uc010hvp.2_Missense_Mutation_p.K156T	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	248					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GCCAAGATCAAGGCTGCCCAA	0.512		NA											137	138					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168807903	168807903	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:168807903T>C	uc003ffi.3	-	14	2991	c.2722A>G	c.(2722-2724)ATT>GTT	p.I908V	MECOM_uc010hwk.1_Missense_Mutation_p.I922V|MECOM_uc003ffj.3_Missense_Mutation_p.I973V|MECOM_uc011bpi.1_Missense_Mutation_p.I900V|MECOM_uc003ffn.3_Missense_Mutation_p.I908V|MECOM_uc003ffk.2_Missense_Mutation_p.I899V|MECOM_uc003ffl.2_Missense_Mutation_p.I1059V|MECOM_uc011bpj.1_Missense_Mutation_p.I1096V|MECOM_uc011bpk.1_Missense_Mutation_p.I898V	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	908	Asp/Glu-rich (acidic).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TTTCCAGTAATATCATTGTCT	0.408		NA											35	199					0	0	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186571026	186571026	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:186571026G>A	uc003fra.2	+	2	263	c.179G>A	c.(178-180)GGC>GAC	p.G60D	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G60D	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	60	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGCAGAGATGGCACCCCTGGT	0.567		NA											9	52					0	0	0	0
LRRC15	131578	broad.mit.edu	37	3	194081062	194081062	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:194081062G>A	uc003ftu.2	-	2	797	c.711C>T	c.(709-711)TCC>TCT	p.S237S	LRRC15_uc003ftt.2_Silent_p.S243S	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	237	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		AGAGACCAGGGGAGAGCAGTC	0.552		NA											5	202					0	0	0	0
GRSF1	2926	broad.mit.edu	37	4	71698926	71698926	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:71698926C>T	uc010iia.1	-	3	662	c.579G>A	c.(577-579)AGG>AGA	p.R193R	GRSF1_uc011caz.1_Silent_p.R75R|GRSF1_uc003hfs.2_Silent_p.R31R	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	193	RRM 1.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			AGGCATCACCCCTTCGTTTCC	0.438		NA											18	61					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72222834	72222834	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:72222834C>A	uc003hfy.2	+	6	777	c.660C>A	c.(658-660)AAC>AAA	p.N220K	SLC4A4_uc010iic.2_Missense_Mutation_p.N220K|SLC4A4_uc010iib.2_Missense_Mutation_p.N220K|SLC4A4_uc003hfz.2_Missense_Mutation_p.N220K|SLC4A4_uc003hgc.3_Missense_Mutation_p.N176K|SLC4A4_uc003hga.2_Missense_Mutation_p.N98K|SLC4A4_uc003hgb.3_Missense_Mutation_p.N176K	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	220	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGAAATCCAACCTTCGGTCCC	0.483		NA											23	88					4.72e-08	5.64e-08	1	0
SHROOM3	57619	broad.mit.edu	37	4	77662554	77662554	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:77662554C>T	uc011cbx.1	+	5	4181	c.3228C>T	c.(3226-3228)CCC>CCT	p.P1076P	SHROOM3_uc011cbz.1_Silent_p.P900P|SHROOM3_uc003hkf.1_Silent_p.P951P|SHROOM3_uc003hkg.2_Silent_p.P854P	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1076					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGTCGGGGCCCGAGCTGAAGC	0.692		NA											10	9					0	0	0	0
NHEDC1	150159	broad.mit.edu	37	4	103912839	103912839	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:103912839A>T	uc003hww.2	-	2	152	c.30T>A	c.(28-30)CAT>CAA	p.H10Q	NHEDC1_uc003hwu.2_Missense_Mutation_p.H10Q|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_5'UTR	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	10						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		CATCCTCCAAATGTTCATTTT	0.264		NA											3	2					0	0	0	0
PCDH18	54510	broad.mit.edu	37	4	138451312	138451312	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:138451312A>C	uc003ihe.3	-	1	2318	c.1931T>G	c.(1930-1932)ATG>AGG	p.M644R	PCDH18_uc003ihf.3_Missense_Mutation_p.M637R|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.M424R|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	644	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AACAGAATCCATGCTAACGTT	0.438		NA											4	185					0	0	0	0
CDH12	1010	broad.mit.edu	37	5	21975279	21975279	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:21975279T>A	uc010iuc.2	-	3	905	c.447A>T	c.(445-447)AAA>AAT	p.K149N	CDH12_uc011cno.1_Missense_Mutation_p.K149N|CDH12_uc003jgk.2_Missense_Mutation_p.K149N	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	149	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TATCCTGCACTTTGATGATGA	0.423		NA								HNSCC(59;0.17)			5	77					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23522937	23522937	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:23522937T>C	uc003jgo.2	+	8	1007	c.825T>C	c.(823-825)CCT>CCC	p.P275P		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	275	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ACTTTGGCCCTTATGAGGGCC	0.557		NA								HNSCC(3;0.000094)			3	84					0	0	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576945	33576945	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:33576945C>T	uc003jia.1	-	19	3349	c.3186G>A	c.(3184-3186)CTG>CTA	p.L1062L	ADAMTS12_uc010iuq.1_Silent_p.L977L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1062	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GTTTCCCACCCAGGTCTCCTT	0.547		NA								HNSCC(64;0.19)			29	49					0	0	0	0
TTC23L	153657	broad.mit.edu	37	5	34880347	34880347	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:34880347G>T	uc003jiu.2	+	9	1114	c.1011G>T	c.(1009-1011)GAG>GAT	p.E337D	TTC23L_uc010iut.1_3'UTR	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	337							binding			central_nervous_system(1)	1						TGGGCTCAGAGGATTTTGAAA	0.348		NA											12	31					1.09e-07	1.29e-07	1	0
ESM1	11082	broad.mit.edu	37	5	54277890	54277890	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:54277890C>T	uc003jpk.2	-	2	455	c.386G>A	c.(385-387)TGC>TAC	p.C129Y	ESM1_uc010ivt.2_Intron	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	129					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			GAATTTCAGGCATTTTCCCGT	0.483		NA											30	36					0	0	0	0
TMEM174	134288	broad.mit.edu	37	5	72469320	72469320	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:72469320A>T	uc010izc.2	+	1	298	c.250A>T	c.(250-252)ACA>TCA	p.T84S		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	84	Helical; (Potential).					integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AGTTGGGGTGACATTCATCCT	0.532		NA											46	85					0	0	0	0
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348		NA											9	35					0.00621372	0.00664143	1	0
ARSK	153642	broad.mit.edu	37	5	94936601	94936601	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:94936601C>T	uc003kld.2	+	7	1305	c.1147C>T	c.(1147-1149)CCG>TCG	p.P383S	ARSK_uc010jbg.2_Missense_Mutation_p.P224S|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	383						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CTCTTTGTTGCCGTTATCATC	0.358		NA											21	36					0	0	0	0
DMXL1	1657	broad.mit.edu	37	5	118445852	118445852	+	Missense_Mutation	SNP	G	G	A	rs141228194		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:118445852G>A	uc003ksd.2	+	5	552	c.371G>A	c.(370-372)CGT>CAT	p.R124H	DMXL1_uc010jcl.1_Missense_Mutation_p.R124H|DMXL1_uc003ksc.1_Missense_Mutation_p.R124H	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	124	WD 1.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTAGGCAGTCGTCTTTTAACT	0.284		NA											7	17					0	0	0	0
ZNF608	57507	broad.mit.edu	37	5	124080411	124080411	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:124080411G>C	uc003ktq.1	-	1	395	c.272C>G	c.(271-273)TCT>TGT	p.S91C	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.S91C|ZNF608_uc003ktt.1_Missense_Mutation_p.S91C	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	91						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTGGGGAGCAGAGGCCTGAAC	0.498		NA											4	61					0	0	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128983577	128983577	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:128983577C>T	uc003kvb.1	+	12	1974	c.1974C>T	c.(1972-1974)CGC>CGT	p.R658R	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	658	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GTCGAGAGCGCAAATGTCCTG	0.507		NA											43	91					0	0	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130897676	130897676	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:130897676T>A	uc003kvn.1	-	5	552	c.346A>T	c.(346-348)ATT>TTT	p.I116F	RAPGEF6_uc003kvp.1_Missense_Mutation_p.I166F|RAPGEF6_uc003kvo.1_Missense_Mutation_p.I116F|RAPGEF6_uc010jdi.1_Missense_Mutation_p.I116F|RAPGEF6_uc010jdj.1_Missense_Mutation_p.I116F|RAPGEF6_uc003kvr.2_Missense_Mutation_p.I116F|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.I116F	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	116					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTTACCACAATCATTTCTGAA	0.303		NA											14	43					0	0	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564246	140564246	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:140564246G>A	uc003liv.2	+	1	3267	c.2112G>A	c.(2110-2112)TCG>TCA	p.S704S	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	704	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTCTTTTCGGTGCTCCTGT	0.697		NA											16	274					0	0	0	0
GABRB2	2561	broad.mit.edu	37	5	160758103	160758103	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:160758103G>C	uc003lys.1	-	9	1082	c.864C>G	c.(862-864)ATC>ATG	p.I288M	GABRB2_uc011deh.1_Missense_Mutation_p.I127M|GABRB2_uc003lyr.1_Missense_Mutation_p.I288M|GABRB2_uc003lyt.1_Missense_Mutation_p.I288M|GABRB2_uc010jiu.1_Missense_Mutation_p.I225M	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	288	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGTGGGTGTTGATTGTGGTCA	0.428		NA											46	81					0	0	0	0
GFOD1	54438	broad.mit.edu	37	6	13365330	13365330	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:13365330G>A	uc003nat.1	-	2	1483	c.818C>T	c.(817-819)CCG>CTG	p.P273L	GFOD1_uc003nas.1_Missense_Mutation_p.P170L	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	273						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			CTCCTGCTCCGGGGCGCTGTT	0.697		NA											32	16					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32041664	32041664	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:32041664T>C	uc003nzl.2	-	12	4643	c.4441A>G	c.(4441-4443)ACA>GCA	p.T1481A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1568	Fibronectin type-III 8.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTGTCACTGTCAGCTCTCCT	0.587		NA											4	14					0	0	0	0
TCP11	6954	broad.mit.edu	37	6	35088707	35088707	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:35088707C>A	uc003okd.2	-	6	914	c.733G>T	c.(733-735)GAA>TAA	p.E245*	TCP11_uc003ojz.1_Nonsense_Mutation_p.E170*|TCP11_uc003oka.2_Nonsense_Mutation_p.E170*|TCP11_uc003okb.2_Nonsense_Mutation_p.E169*|TCP11_uc003okc.2_Nonsense_Mutation_p.E169*|TCP11_uc011dsu.1_Nonsense_Mutation_p.E227*|TCP11_uc011dsv.1_Nonsense_Mutation_p.E194*|TCP11_uc011dsw.1_Nonsense_Mutation_p.E199*	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	232					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						TTGAGGAGTTCCTGGAATTTA	0.443		NA											94	276					1.41e-40	1.85e-40	1	0
DNAH8	1769	broad.mit.edu	37	6	38843395	38843395	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:38843395C>T	uc003ooe.1	+	51	7598	c.6998C>T	c.(6997-6999)CCC>CTC	p.P2333L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGGTTAATTCCCTCCAAAGAA	0.289		NA											24	5					0	0	0	0
BYSL	705	broad.mit.edu	37	6	41899233	41899233	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:41899233C>T	uc003orl.2	+	5	1140	c.804C>T	c.(802-804)CTC>CTT	p.L268L		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	268					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACAAACGACTCAACTTCCATC	0.522		NA											31	80					0	0	0	0
C6orf153	88745	broad.mit.edu	37	6	42996851	42996851	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:42996851T>A	uc003otp.1	+	7	673	c.665T>A	c.(664-666)CTA>CAA	p.L222Q		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	222					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CAGTTGGCACTAGCTGAGAAG	0.483		NA											192	285					0	0	0	0
RSPH9	221421	broad.mit.edu	37	6	43618143	43618143	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:43618143C>A	uc003ovw.1	+	2	285	c.259C>A	c.(259-261)CCT>ACT	p.P87T	RSPH9_uc003ovx.1_Missense_Mutation_p.P87T	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	87					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						CCTCTTGCCCCCTGCCACAGA	0.537		NA							Kartagener_syndrome				14	81					0.000151284	0.000168462	1	0
HMGCLL1	54511	broad.mit.edu	37	6	55304315	55304315	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:55304315C>T	uc003pcn.2	-	9	1087	c.928G>A	c.(928-930)GGC>AGC	p.G310S	HMGCLL1_uc003pco.2_Missense_Mutation_p.G280S|HMGCLL1_uc010jzx.2_Missense_Mutation_p.G181S|HMGCLL1_uc011dxc.1_Missense_Mutation_p.G248S|HMGCLL1_uc011dxd.1_Missense_Mutation_p.G177S|HMGCLL1_uc011dxe.1_Missense_Mutation_p.G114S	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	310							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TAAGGGCAGCCACCTAATCCG	0.428		NA											38	41					0	0	0	0
ZNF451	26036	broad.mit.edu	37	6	56997899	56997899	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:56997899A>C	uc003pdm.1	+	6	708	c.484A>C	c.(484-486)ACG>CCG	p.T162P	ZNF451_uc003pdl.2_Missense_Mutation_p.T162P|ZNF451_uc003pdn.1_Missense_Mutation_p.T162P|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.T162P	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AGGAGGCCACACGTGGGTGTC	0.393		NA											15	47					0	0	0	0
MANEA	79694	broad.mit.edu	37	6	96053864	96053864	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:96053864T>C	uc003poo.1	+	5	1112	c.972T>C	c.(970-972)TTT>TTC	p.F324F		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	324	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACACATATTTTGCCACAAATG	0.343		NA											17	12					0	0	0	0
USP45	85015	broad.mit.edu	37	6	99883592	99883592	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:99883592T>C	uc003ppx.2	-	18	2978	c.2445A>G	c.(2443-2445)TAA>TAG	p.*815*	USP45_uc003ppv.2_RNA|USP45_uc003ppw.2_Silent_p.*495*	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	815					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		CCATTAATAGTTATAATACTC	0.363		NA											18	12					0	0	0	0
OSTM1	28962	broad.mit.edu	37	6	108395812	108395812	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:108395812G>T	uc003psd.2	-	1	130	c.44C>A	c.(43-45)CCG>CAG	p.P15Q		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	15						integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		CAGCCACGGCGGCAACGAACA	0.751		NA											6	6					8.13e-05	9.09e-05	1	0
AKD1	221264	broad.mit.edu	37	6	109819090	109819090	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:109819090T>C	uc003ptn.2	-	37	5202	c.5125A>G	c.(5125-5127)AGA>GGA	p.R1709G	AKD1_uc011eas.1_Missense_Mutation_p.R94G	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1709					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGTGTCAGTCTTTTGGGGATC	0.473		NA											22	27					0	0	0	0
C6orf58	352999	broad.mit.edu	37	6	127911377	127911377	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:127911377A>G	uc003qbh.2	+	5	832	c.820A>G	c.(820-822)ACT>GCT	p.T274A		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	274						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		TCTTCTTAATACTGATGTAGC	0.398		NA											51	38					0	0	0	0
RAET1G	353091	broad.mit.edu	37	6	150240749	150240749	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:150240749C>A	uc010kii.1	-	2	357	c.289G>T	c.(289-291)GTG>TTG	p.V97L	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	97	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		ATGTCCACCACCTCTCTCAGT	0.507		NA											45	129					3.05e-18	3.91e-18	1	0
SYNE1	23345	broad.mit.edu	37	6	152542128	152542128	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:152542128A>G	uc010kiw.2	-	119	22312	c.21710T>C	c.(21709-21711)CTA>CCA	p.L7237P	SYNE1_uc010kiv.2_Missense_Mutation_p.L1761P|SYNE1_uc003qos.3_Missense_Mutation_p.L1761P|SYNE1_uc003qot.3_Missense_Mutation_p.L7166P|SYNE1_uc003qou.3_Missense_Mutation_p.L7237P|SYNE1_uc003qor.3_Missense_Mutation_p.L137P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7237	HAT 10.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGCTGAAGTAGGGCCTTGCT	0.478		NA								HNSCC(10;0.0054)			24	40					0	0	0	0
ISPD	729920	broad.mit.edu	37	7	16415830	16415830	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:16415830C>T	uc010ktx.2	-	3	571	c.571G>A	c.(571-573)GTC>ATC	p.V191I	ISPD_uc010kty.2_Intron	NM_001101426	NP_001094896	A4D126	ISPD_HUMAN	notch1-induced protein isoform a	191					isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1						GATGGACTGACGACAGTAGAT	0.418		NA								Multiple Myeloma(15;0.18)			13	24					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31682803	31682803	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:31682803G>C	uc003tcj.1	+	11	2812	c.1819G>C	c.(1819-1821)GAC>CAC	p.D607H	CCDC129_uc011kad.1_Missense_Mutation_p.D617H|CCDC129_uc003tci.1_Missense_Mutation_p.D458H|CCDC129_uc011kae.1_Missense_Mutation_p.D633H|CCDC129_uc003tck.1_Missense_Mutation_p.D515H	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	607											0						TCATACTCAAGACAAGTTCCT	0.493		NA											42	95					0	0	0	0
ZNF117	51351	broad.mit.edu	37	7	64438979	64438979	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:64438979T>A	uc003ttr.2	-	4	2255	c.970A>T	c.(970-972)AAA>TAA	p.K324*		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	324	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TGAATTTTTTTATGGTCAGTA	0.353		NA											23	39					0	0	0	0
AUTS2	26053	broad.mit.edu	37	7	69064922	69064922	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:69064922A>C	uc003tvw.3	+	1	1026	c.283A>C	c.(283-285)AGC>CGC	p.S95R	AUTS2_uc003tvv.3_Missense_Mutation_p.S95R|AUTS2_uc003tvx.3_Missense_Mutation_p.S95R	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	95										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TGCCATGACCAGCTTTGTCAC	0.657		NA											8	25					0	0	0	0
CROT	54677	broad.mit.edu	37	7	87022283	87022283	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:87022283G>T	uc003uit.2	+	17	1863	c.1618G>T	c.(1618-1620)GTT>TTT	p.V540F	CROT_uc003uiu.2_Missense_Mutation_p.V568F	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	540					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGGAAATTTTGTTCTCTCAAC	0.383		NA											44	62					1.42e-22	1.82e-22	1	0
CUX1	1523	broad.mit.edu	37	7	101845472	101845472	+	Silent	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:101845472C>A	uc003uyx.3	+	18	2933	c.2895C>A	c.(2893-2895)ATC>ATA	p.I965I	CUX1_uc003uys.3_Silent_p.I976I|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	965	CUT 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCCAGAGAATCTTCGGGGAGA	0.562		NA											10	94					0.000442599	0.000490899	1	0
RELN	5649	broad.mit.edu	37	7	103123326	103123326	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:103123326A>G	uc003vca.2	-	63	10434	c.10274T>C	c.(10273-10275)GTC>GCC	p.V3425A	RELN_uc010liz.2_Missense_Mutation_p.V3425A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3425					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCACAGGACGACCTCCACATG	0.473		NA											19	62					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103163863	103163863	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:103163863C>T	uc003vca.2	-	47	7625	c.7465G>A	c.(7465-7467)GGG>AGG	p.G2489R	RELN_uc010liz.2_Missense_Mutation_p.G2489R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2489	EGF-like 6.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATGCATCTCCCATGGCCACTG	0.458		NA											42	63					0	0	0	0
CPA5	93979	broad.mit.edu	37	7	130008281	130008281	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:130008281C>G	uc010lmd.1	+	14	1774	c.1154C>G	c.(1153-1155)GCC>GGC	p.A385G	CPA5_uc003vps.2_Missense_Mutation_p.A385G|CPA5_uc003vpt.2_Missense_Mutation_p.P357A|CPA5_uc010lme.1_Missense_Mutation_p.A385G|CPA5_uc003vpu.1_Missense_Mutation_p.A385G|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	385					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GTCGACTGGGCCTATGACAGT	0.562		NA											4	116					0	0	0	0
WDR91	29062	broad.mit.edu	37	7	134878366	134878366	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:134878366T>G	uc003vsp.2	-	10	1516	c.1454A>C	c.(1453-1455)AAT>ACT	p.N485T	WDR91_uc010lmq.2_Missense_Mutation_p.N74T|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	485	WD 2.									breast(2)|ovary(1)|skin(1)	4						TTCACAGAGATTCTTCTTGGC	0.572		NA											9	24					0	0	0	0
GSTK1	373156	broad.mit.edu	37	7	142961250	142961250	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:142961250G>A	uc003wci.2	+	2	229	c.144G>A	c.(142-144)ATG>ATA	p.M48I	GSTK1_uc011ksy.1_Missense_Mutation_p.M48I|GSTK1_uc003wcj.2_Missense_Mutation_p.M48I|GSTK1_uc011ksz.1_Missense_Mutation_p.M48I	NM_015917	NP_057001	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1 isoform a	48						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity				0	Melanoma(164;0.059)				Glutathione(DB00143)	CAGGGATCATGAAAGACAGTG	0.567		NA											16	22					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3059180	3059180	+	Silent	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:3059180G>A	uc011kwk.1	-	32	5445	c.5055C>T	c.(5053-5055)ACC>ACT	p.T1685T	CSMD1_uc011kwj.1_Silent_p.T1077T|CSMD1_uc003wqe.2_Silent_p.T841T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1685	Extracellular (Potential).|CUB 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTGTGCATGGGTTCCATCAA	0.438		NA											7	11					0	0	0	0
CLDN23	137075	broad.mit.edu	37	8	8560453	8560453	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:8560453C>T	uc003wsi.2	+	1	788	c.545C>T	c.(544-546)GCG>GTG	p.A182V		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	182	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CTCAGCTTCGCGCCCTGGTGC	0.726		NA											13	15					0	0	0	0
NEFM	4741	broad.mit.edu	37	8	24772151	24772151	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:24772151A>G	uc003xed.3	+	1	878	c.845A>G	c.(844-846)GAC>GGC	p.D282G	NEFM_uc011lac.1_Missense_Mutation_p.D282G|NEFM_uc010lue.2_5'Flank|uc010luc.1_5'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	282	Rod.|Coil 2A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AGCCACTCAGACCAGAATATG	0.587		NA											9	72					0	0	0	0
SCARA5	286133	broad.mit.edu	37	8	27779108	27779108	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:27779108C>T	uc003xgj.2	-	4	1336	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	SCARA5_uc010luz.2_Intron|SCARA5_uc003xgk.2_Missense_Mutation_p.R256Q|SCARA5_uc003xgl.2_Missense_Mutation_p.R299Q	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	299	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		GGAGATGTTCCGCAGTGCGAT	0.537		NA											10	37					0	0	0	0
ZNF704	619279	broad.mit.edu	37	8	81553638	81553638	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:81553638C>G	uc003yby.1	-	9	1434	c.1202G>C	c.(1201-1203)TGC>TCC	p.C401S		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	401						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CTTCCAGCGGCAGGCGGTACA	0.627		NA											4	19					0	0	0	0
MATN2	4147	broad.mit.edu	37	8	99015907	99015907	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:99015907T>A	uc003yic.2	+	8	1454	c.1223T>A	c.(1222-1224)CTG>CAG	p.L408Q	MATN2_uc003yib.1_Missense_Mutation_p.L408Q|MATN2_uc010mbh.1_Missense_Mutation_p.L367Q|MATN2_uc003yid.2_Missense_Mutation_p.L408Q|MATN2_uc003yie.1_Missense_Mutation_p.L408Q|MATN2_uc010mbi.1_Missense_Mutation_p.L241Q	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	408	EGF-like 5.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TACTGTGCACTGAACAAACCG	0.597		NA											9	75					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113657362	113657362	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:113657362T>A	uc003ynu.2	-	20	3445	c.3286A>T	c.(3286-3288)ACT>TCT	p.T1096S	CSMD3_uc003yns.2_Missense_Mutation_p.T368S|CSMD3_uc003ynt.2_Missense_Mutation_p.T1056S|CSMD3_uc011lhx.1_Missense_Mutation_p.T992S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1096	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATCAACAGTCCATGTACAA	0.353		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	42					0	0	0	0
KCNK9	51305	broad.mit.edu	37	8	140631071	140631071	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:140631071G>C	uc003yvf.1	-	2	619	c.555C>G	c.(553-555)AGC>AGG	p.S185R	KCNK9_uc003yvg.1_Missense_Mutation_p.S185R|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	185	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGTGGAAGAAGCTCCACTCCT	0.592		NA											19	41					0	0	0	0
DNAI1	27019	broad.mit.edu	37	9	34506628	34506628	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:34506628A>G	uc003zum.2	+	13	1260	c.1067A>G	c.(1066-1068)GAC>GGC	p.D356G		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	356					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		TGGGTAGATGACTTCATGAAG	0.607		NA							Kartagener_syndrome				10	58					0	0	0	0
VCP	7415	broad.mit.edu	37	9	35060329	35060329	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:35060329A>C	uc003zvy.2	-	13	2065	c.1676T>G	c.(1675-1677)GTC>GGC	p.V559G	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.V228G|VCP_uc010mki.1_Missense_Mutation_p.V514G	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	559					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GATTTCTCTGACATTGGCCTC	0.458		NA											19	26					0	0	0	0
SHB	6461	broad.mit.edu	37	9	38016101	38016101	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:38016101G>A	uc004aax.2	-	2	1313	c.745C>T	c.(745-747)CCC>TCC	p.P249S		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	249	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCATCAAAGGGATCTGAGTAG	0.502		NA											40	73					0	0	0	0
TMEM2	23670	broad.mit.edu	37	9	74319658	74319658	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:74319658G>A	uc011lsa.1	-	18	3587	c.3047C>T	c.(3046-3048)CCG>CTG	p.P1016L	TMEM2_uc011lrz.1_Missense_Mutation_p.P9L|TMEM2_uc010mos.2_Missense_Mutation_p.P953L|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1016						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGGTTGGACGGATACTCATC	0.438		NA											20	28					0	0	0	0
FAM75C1	441452	broad.mit.edu	37	9	90538237	90538237	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:90538237G>A	uc010mqi.2	+	4	3444	c.3415G>A	c.(3415-3417)GAT>AAT	p.D1139N	FAM75C1_uc004apq.3_Missense_Mutation_p.D1122N	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACAAATCAGAGATCAGCAGCC	0.527		NA											51	190					0	0	0	0
C9orf102	375748	broad.mit.edu	37	9	98678056	98678056	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:98678056C>T	uc004avt.3	+	5	1316	c.928C>T	c.(928-930)CTC>TTC	p.L310F	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.L12F|C9orf102_uc010mry.1_Missense_Mutation_p.L12F|C9orf102_uc010mrz.2_Missense_Mutation_p.L121F	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	310	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				CCGCATTGGCCTCACTGGAAC	0.383		NA											12	36					0	0	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617533	111617533	+	Silent	SNP	C	C	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:111617533C>T	uc004bdi.2	-	1	743	c.678G>A	c.(676-678)GGG>GGA	p.G226G		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	226						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TGAGGTCACCCCCAGCGTAGT	0.647		NA											13	47					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113169571	113169571	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:113169571C>A	uc010mtz.2	-	38	8646	c.8309G>T	c.(8308-8310)TGT>TTT	p.C2770F	SVEP1_uc010mty.2_Missense_Mutation_p.C696F	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2770	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AATGGCTTCACAGCGTGGGGA	0.468		NA											9	106					2.18e-05	2.48e-05	1	0
C9orf171	389799	broad.mit.edu	37	9	135447890	135447890	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:135447890A>C	uc004cbn.2	+	7	1004	c.956A>C	c.(955-957)CAC>CCC	p.H319P	C9orf171_uc004cbo.2_Missense_Mutation_p.H283P	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	319										ovary(4)|large_intestine(1)	5						AACTACACCCACCCCTAGCCC	0.597		NA											6	18					0	0	0	0
KDM6A	7403	broad.mit.edu	37	X	44942704	44942704	+	Splice_Site	SNP	G	G	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:44942704G>A	uc004dge.3	+	23	3660	c.3285_splice	c.e23-1	p.K1095_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1147_splice|KDM6A_uc011mla.1_Splice_Site_p.K1050_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1102_splice|KDM6A_uc011mlc.1_Splice_Site_p.K799_splice|KDM6A_uc011mld.1_Splice_Site_p.K734_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTTTATTGCAGGTGGAAGTTG	0.393		NA	D|N|F|S		renal|oesophageal SCC|MM								8	2					0	0	0	0
TAF1	6872	broad.mit.edu	37	X	70674608	70674608	+	Silent	SNP	T	T	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:70674608T>C	uc004dzu.3	+	34	4887	c.4836T>C	c.(4834-4836)ACT>ACC	p.T1612T	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.T1633T|TAF1_uc004dzv.3_Silent_p.T786T|TAF1_uc010nld.1_RNA|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_Silent_p.T37T|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA|TAF1_uc004dzw.1_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1612	Interaction with ASF1A and ASF1B.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AACATTTGACTCAACTTGAGA	0.318		NA											13	3					0	0	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857289	101857289	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:101857289A>T	uc004ejg.2	+	6	1101	c.220A>T	c.(220-222)ACA>TCA	p.T74S	ARMCX5_uc004ejh.2_Missense_Mutation_p.T74S	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	74							binding			ovary(1)	1						TATGGCTGTGACAAGGGAAGT	0.483		NA											26	25					0	0	0	0
COL4A6	1288	broad.mit.edu	37	X	107413937	107413937	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:107413937C>G	uc004enw.3	-	35	3501	c.3398G>C	c.(3397-3399)GGA>GCA	p.G1133A	COL4A6_uc004env.3_Missense_Mutation_p.G1132A|COL4A6_uc011msn.1_Missense_Mutation_p.G1132A|COL4A6_uc010npk.2_Missense_Mutation_p.G1132A	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1133	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GCCGGCAACTCCTGGAAATCC	0.493		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				21	78					0	0	0	0
GLUD2	2747	broad.mit.edu	37	X	120182629	120182629	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:120182629C>A	uc004eto.2	+	1	1168	c.1091C>A	c.(1090-1092)GCA>GAA	p.A364E		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	364					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTCCCCAAGGCAAAGCCCTAT	0.493		NA											85	33					1.35e-34	1.76e-34	1	0
CELSR2	1952	broad.mit.edu	37	1	109795741	109795743	+	In_Frame_Del	DEL	CTT	CTT	-	rs115856488	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:109795741_109795743delCTT	uc001dxa.3	+	1	3101_3103	c.3040_3042delCTT	c.(3040-3042)CTTdel	p.L1014del		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1014	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGTCCGCCTCCTTGACCGCAATG	0.581		NA											27	73	---	---	---	---	NA	NA	NA	NA
CEPT1	10390	broad.mit.edu	37	1	111726202	111726203	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:111726202_111726203delTT	uc001eah.1	+	8	1332_1333	c.1124_1125delTT	c.(1123-1125)ATTfs	p.I375fs	CEPT1_uc001eai.1_Frame_Shift_Del_p.I375fs|CEPT1_uc001eaj.1_Frame_Shift_Del_p.I375fs|CEPT1_uc009wfz.1_Frame_Shift_Del_p.I109fs	NM_001007794	NP_001007795	Q9Y6K0	CEPT1_HUMAN	choline/ethanolaminephosphotransferase	375	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	GTACTTTGGATTGCCCTGGTAA	0.361		NA											25	78	---	---	---	---	NA	NA	NA	NA
TNR	7143	broad.mit.edu	37	1	175372692	175372692	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:175372692delC	uc001gkp.1	-	2	641	c.560delG	c.(559-561)GGCfs	p.G187fs	TNR_uc009wwu.1_Frame_Shift_Del_p.G187fs|TNR_uc010pmz.1_Frame_Shift_Del_p.G187fs	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	187	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GCAGATGCAGCCACAGGACTC	0.577		NA											20	128	---	---	---	---	NA	NA	NA	NA
PEX16	9409	broad.mit.edu	37	11	45937775	45937776	+	Splice_Site	INS	-	-	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:45937775_45937776insA	uc001nbu.2	-	3	537	c.225_splice	c.e3+1	p.V75_splice	PEX16_uc001nbt.2_Splice_Site_p.V75_splice	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1						ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)		GCAGAATTCTCACCACAGGCAA	0.52		NA											34	218	---	---	---	---	NA	NA	NA	NA
FRY	10129	broad.mit.edu	37	13	32798467	32798468	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:32798467_32798468insC	uc001utx.2	+	37	5357_5358	c.4861_4862insC	c.(4861-4863)GCCfs	p.A1621fs	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGGATGCTGGGCCCCCCTGGTT	0.569		NA											41	54	---	---	---	---	NA	NA	NA	NA
RASA3	22821	broad.mit.edu	37	13	114839224	114839225	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:114839224_114839225insA	uc001vui.2	-	2	274_275	c.143_144insT	c.(142-144)TTCfs	p.F48fs	RASA3_uc010tkk.1_Frame_Shift_Ins_p.F16fs|RASA3_uc001vuj.2_5'UTR|RASA3_uc010tkl.1_RNA	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	48	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TTTTGGTCCTGAAAACCTCCTC	0.465		NA											28	82	---	---	---	---	NA	NA	NA	NA
SPG11	80208	broad.mit.edu	37	15	44941194	44941195	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:44941194_44941195delAG	uc001ztx.2	-	7	1502_1503	c.1471_1472delCT	c.(1471-1473)CTGfs	p.L491fs	SPG11_uc010ueh.1_Frame_Shift_Del_p.L491fs|SPG11_uc010uei.1_Frame_Shift_Del_p.L491fs|SPG11_uc001zua.1_Frame_Shift_Del_p.L491fs	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	491	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AAACAAAATCAGAGAGAGTCCA	0.337		NA											12	21	---	---	---	---	NA	NA	NA	NA
PDPK1	5170	broad.mit.edu	37	16	2611896	2611899	+	Frame_Shift_Del	DEL	CGAC	CGAC	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:2611896_2611899delCGAC	uc002cqs.2	+	4	597_600	c.453_456delCGAC	c.(451-456)GACGACfs	p.D151fs	PDPK1_uc002cqt.2_Intron|PDPK1_uc010bsn.2_Frame_Shift_Del_p.D151fs|PDPK1_uc002cqu.2_Frame_Shift_Del_p.D124fs|PDPK1_uc002cqv.1_Frame_Shift_Del_p.D124fs|PDPK1_uc010uwe.1_3'UTR|uc010bsp.1_3'UTR	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	151_152	Protein kinase.				actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	CATTTCAGGACGACGAGAAGCTGT	0.52		NA											2	4	---	---	---	---	NA	NA	NA	NA
G6PC	2538	broad.mit.edu	37	17	41056042	41056043	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:41056042_41056043delTG	uc002icb.1	+	2	404_405	c.325_326delTG	c.(325-327)TGTfs	p.C109fs	G6PC_uc010whf.1_Frame_Shift_Del_p.C111fs	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	109	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CCCTGTAACCTGTGAGACTGGA	0.515		NA							Glycogen_Storage_Disease_type_Ia				34	66	---	---	---	---	NA	NA	NA	NA
PAX1	5075	broad.mit.edu	37	20	21695398	21695398	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:21695398delT	uc002wsj.2	+	5	1616	c.1562delT	c.(1561-1563)CTTfs	p.L521fs	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	521					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CCACACTTCCTTTATTGGTCT	0.637		NA											15	44	---	---	---	---	NA	NA	NA	NA
RIPK4	54101	broad.mit.edu	37	21	43166897	43166898	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr21:43166897_43166898insA	uc002yzn.1	-	5	755_756	c.707_708insT	c.(706-708)GTGfs	p.V236fs		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	236						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GGCCCTTCACCACCTTCACCAT	0.663		NA											16	149	---	---	---	---	NA	NA	NA	NA
MST1	4485	broad.mit.edu	37	3	49723322	49723327	+	In_Frame_Del	DEL	GCGCTG	GCGCTG	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:49723322_49723327delGCGCTG	uc003cxg.2	-	10	1288_1293	c.1216_1221delCAGCGC	c.(1216-1221)CAGCGCdel	p.QR406del	MST1_uc011bcs.1_In_Frame_Del_p.444_446ASA>A	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	392_393	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGCGGACCAGCGCTGGCACTGGACA	0.704		NA											8	103	---	---	---	---	NA	NA	NA	NA
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:147560457_147560458insGGC	uc003ikv.2	+	1	413_414	c.165_166insGGC	c.(163-168)insGGC	p.68_69insG		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	68_69					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.386		NA											8	11	---	---	---	---	NA	NA	NA	NA
CMBL	134147	broad.mit.edu	37	5	10286575	10286580	+	In_Frame_Del	DEL	TTGTTT	TTGTTT	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:10286575_10286580delTTGTTT	uc003jes.2	-	4	803_808	c.352_357delAAACAA	c.(352-357)AAACAAdel	p.KQ118del		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase	118_119						cytosol	hydrolase activity|protein binding			skin(1)	1						CATGACACTGTTGTTTCAGATACTTC	0.422		NA											7	31	---	---	---	---	NA	NA	NA	NA
NSD1	64324	broad.mit.edu	37	5	176638656	176638662	+	Frame_Shift_Del	DEL	AGTAAAG	AGTAAAG	-			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:176638656_176638662delAGTAAAG	uc003mfr.3	+	5	3394_3400	c.3256_3262delAGTAAAG	c.(3256-3264)AGTAAAGAGfs	p.S1086fs	NSD1_uc003mft.3_Frame_Shift_Del_p.S817fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.S983fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.S734fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1086_1088					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAAGATCCTAGTAAAGAGGATCCCCT	0.449		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			66	24	---	---	---	---	NA	NA	NA	NA
TRPS1	7227	broad.mit.edu	37	8	116616583	116616584	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:116616583_116616584insA	uc003ynz.2	-	3	2032_2033	c.1573_1574insT	c.(1573-1575)TGTfs	p.C525fs	TRPS1_uc011lhy.1_Frame_Shift_Ins_p.C529fs|TRPS1_uc003yny.2_Frame_Shift_Ins_p.C538fs|TRPS1_uc010mcy.2_Frame_Shift_Ins_p.C525fs	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	525					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ACAGAACTGACAATTATAGCTC	0.46		NA							Langer-Giedion_syndrome				130	65	---	---	---	---	NA	NA	NA	NA
