Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MAN1C1	57134	broad.mit.edu	37	1	25944551	25944551	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:25944551C>T	uc001bkm.2	+	1	593	c.263C>T	c.(262-264)GCG>GTG	p.A88V	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	88	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		gcccccgccgcgccggccccg	0.642		NA											4	7					0	0	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52911973	52911973	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:52911973C>G	uc001ctx.2	-	22	3889	c.3655G>C	c.(3655-3657)GAG>CAG	p.E1219Q	ZCCHC11_uc001cty.2_Missense_Mutation_p.E1219Q|ZCCHC11_uc001ctz.2_Missense_Mutation_p.E1219Q|ZCCHC11_uc009vze.1_Missense_Mutation_p.E1219Q|ZCCHC11_uc009vzf.1_Missense_Mutation_p.E940Q|ZCCHC11_uc001cua.1_Missense_Mutation_p.E136Q	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	1219	PAP-associated 2.				miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						CACTGCTTCTCAAAAGTTGTC	0.393		NA											25	67					0	0	0	0
LRRC42	115353	broad.mit.edu	37	1	54423865	54423865	+	Silent	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:54423865C>A	uc001cwj.1	+	3	717	c.517C>A	c.(517-519)CGG>AGG	p.R173R	LRRC42_uc001cwl.1_Silent_p.R173R|LRRC42_uc001cwk.1_Silent_p.R173R|LRRC42_uc009vzm.1_Silent_p.R173R	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	173											0						TAAGTCTTTCCGGGAGCTGAC	0.468		NA											8	53					0.000274275	0.000284182	1	0
CLCA2	9635	broad.mit.edu	37	1	86919185	86919185	+	Silent	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:86919185G>T	uc001dlr.3	+	13	2451	c.2289G>T	c.(2287-2289)GTG>GTT	p.V763V		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	763	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		ACCCTGATGTGTTTCCACCAT	0.517		NA											22	61					1.11e-12	1.19e-12	1	0
GBP1	2633	broad.mit.edu	37	1	89525943	89525944	+	Missense_Mutation	DNP	GT	GT	TG			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:89525943_89525944GT>TG	uc001dmx.2	-	3	474_475	c.254_255AC>CA	c.(253-255)CAC>CCA	p.H85P		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	85					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GCTTCTTGGGGTGGGGCACACA	0.564		NA											11	93					0	0	0	0
COPA	1314	broad.mit.edu	37	1	160303419	160303419	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:160303419C>T	uc009wti.2	-	5	754	c.360G>A	c.(358-360)TGG>TGA	p.W120*	COPA_uc001fvv.3_Nonsense_Mutation_p.W120*|COPA_uc009wtj.1_Nonsense_Mutation_p.W66*	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	120	WD 3.				COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATTGCCAGTTCCACACTCGGA	0.413		NA											22	44					0	0	0	0
F5	2153	broad.mit.edu	37	1	169525915	169525915	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:169525915G>A	uc001ggg.1	-	6	1066	c.921C>T	c.(919-921)ATC>ATT	p.I307I	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	307	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAGAAGATATGATCCACTTTC	0.483		NA											11	50					0	0	0	0
C1orf129	80133	broad.mit.edu	37	1	170959143	170959143	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:170959143G>A	uc001ghg.2	+	11	1157	c.1027G>A	c.(1027-1029)GAC>AAC	p.D343N	C1orf129_uc009wvy.2_Missense_Mutation_p.D150N|C1orf129_uc010plz.1_Missense_Mutation_p.D343N	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	343							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCCAGCAGACGAGTAAGGCCC	0.488		NA											6	22					0	0	0	0
TOR3A	64222	broad.mit.edu	37	1	179063234	179063234	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:179063234C>T	uc001gmd.2	+	5	977	c.825C>T	c.(823-825)CTC>CTT	p.L275L	TOR3A_uc010pnd.1_Silent_p.L59L	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	275					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						TCAGTAATCTCAGGGGCGATA	0.463		NA											17	71					0	0	0	0
DHX9	1660	broad.mit.edu	37	1	182835672	182835672	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:182835672G>A	uc001gpr.2	+	13	1589	c.1426G>A	c.(1426-1428)GAG>AAG	p.E476K	DHX9_uc001gps.2_Missense_Mutation_p.E262K	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	476	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						CGTTCGATTTGAGTCTATACT	0.428		NA											57	151					0	0	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235634193	235634193	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:235634193C>A	uc001hxc.2	-	6	962	c.733G>T	c.(733-735)GAT>TAT	p.D245Y	B3GALNT2_uc001hxd.1_Missense_Mutation_p.D286Y	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	245	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			CCCCCTCCATCATTCACTGTC	0.358		NA											29	74					2.46e-21	2.67e-21	1	0
SCCPDH	51097	broad.mit.edu	37	1	246927581	246927581	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:246927581G>A	uc001ibr.2	+	10	1371	c.1024G>A	c.(1024-1026)GGT>AGT	p.G342S		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	342						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		GACATTCTTTGGTCAAGGATA	0.408		NA											22	64					0	0	0	0
OR11L1	391189	broad.mit.edu	37	1	248005106	248005106	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:248005106G>T	uc001idn.1	-	1	93	c.93C>A	c.(91-93)TTC>TTA	p.F31L		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGATGAGCAGGAAAATGACAA	0.507		NA											11	36					5.51e-06	5.77e-06	1	0
PGBD2	267002	broad.mit.edu	37	1	249211968	249211968	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:249211968G>T	uc001ifh.2	+	3	1332	c.1185G>T	c.(1183-1185)AGG>AGT	p.R395S	PGBD2_uc001ifg.2_Missense_Mutation_p.R144S|PGBD2_uc009xhd.2_Missense_Mutation_p.R392S	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	395										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AAATGAAGAGGGGTTCATTTG	0.478		NA											21	49					4.35e-09	4.63e-09	1	0
KLF6	1316	broad.mit.edu	37	10	3822362	3822362	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:3822362C>G	uc001iha.2	-	3	1003	c.736G>C	c.(736-738)GAG>CAG	p.E246Q	KLF6_uc010qaj.1_Intron|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.E204Q	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	246	C2H2-type 2.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		CTGGTTAACTCATCACTTCTT	0.542		NA											24	80					0	0	0	0
SVIL	6840	broad.mit.edu	37	10	29821993	29821993	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:29821993C>T	uc001iut.1	-	8	2056	c.1303G>A	c.(1303-1305)GAA>AAA	p.E435K	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.E435K	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	435					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				tcttctccttctccttcccct	0.408		NA											23	22					0	0	0	0
FZD8	8325	broad.mit.edu	37	10	35929479	35929479	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:35929479G>A	uc001iyz.1	-	1	884	c.879C>T	c.(877-879)TTC>TTT	p.F293F		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	293	Helical; Name=1; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						AGACGGTGGCGAAGGTGGACA	0.622		NA											19	26					0	0	0	0
PAX2	5076	broad.mit.edu	37	10	102510539	102510539	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:102510539G>T	uc001krk.3	+	3	851	c.301G>T	c.(301-303)GAA>TAA	p.E101*	PAX2_uc001krl.3_Nonsense_Mutation_p.E101*|PAX2_uc001krm.3_Nonsense_Mutation_p.E101*|PAX2_uc001kro.3_Nonsense_Mutation_p.E101*|PAX2_uc001krn.3_Nonsense_Mutation_p.E101*|PAX2_uc010qps.1_Nonsense_Mutation_p.E100*|PAX2_uc001krp.1_Nonsense_Mutation_p.E105*	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	101	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CAAGATTGCTGAATACAAACG	0.587		NA											32	35					1.56e-22	1.71e-22	1	0
SFXN4	119559	broad.mit.edu	37	10	120917539	120917539	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:120917539C>A	uc001leb.2	-	7	441	c.396G>T	c.(394-396)AAG>AAT	p.K132N	SFXN4_uc001ldy.2_Missense_Mutation_p.K16N|SFXN4_uc001ldz.2_Missense_Mutation_p.K16N|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	132					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		AAATCACGGACTTGATCCCTT	0.428		NA											8	52					5.49e-09	5.82e-09	1	0
SFXN4	119559	broad.mit.edu	37	10	120917544	120917544	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:120917544T>A	uc001leb.2	-	7	436	c.391A>T	c.(391-393)ATC>TTC	p.I131F	SFXN4_uc001ldy.2_Missense_Mutation_p.I15F|SFXN4_uc001ldz.2_Missense_Mutation_p.I15F|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	131	Helical; (Potential).				iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		ACGGACTTGATCCCTTTCAGT	0.418		NA											8	48					0	0	0	0
OR52A4	390053	broad.mit.edu	37	11	5142643	5142643	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:5142643C>T	uc001lzz.1	-	1	166	c.166G>A	c.(166-168)GAG>AAG	p.E56K	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGGCTTGGCTCAGATTTGATG	0.428		NA											20	48					0	0	0	0
HBE1	3046	broad.mit.edu	37	11	5290881	5290881	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:5290881G>T	uc001mal.1	-	2	371	c.118C>A	c.(118-120)CAG>AAG	p.Q40K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Missense_Mutation_p.Q40K	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	40					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAAATCTCTGGGTCCAGGGG	0.463		NA											17	41					4.75e-09	5.05e-09	1	0
CYB5R2	51700	broad.mit.edu	37	11	7689018	7689018	+	Missense_Mutation	SNP	G	G	A	rs149733078		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:7689018G>A	uc001mfm.2	-	7	737	c.499C>T	c.(499-501)CGC>TGC	p.R167C	CYB5R2_uc001mfn.2_RNA|CYB5R2_uc009yfk.2_Missense_Mutation_p.R167C	NM_016229	NP_057313	Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase b5R.2	167	FAD (By similarity).				sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity				0				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGATGTGGCGAATGAGCTGC	0.552		NA											19	68					0	0	0	0
CD44	960	broad.mit.edu	37	11	35223298	35223298	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:35223298C>T	uc001mvu.2	+	9	1551	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	CD44_uc001mvv.2_Missense_Mutation_p.H330Y|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Intron|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	373	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CCATGAGCATCATGAGGAAGA	0.463		NA											4	31					0	0	0	0
OR5D16	390144	broad.mit.edu	37	11	55606668	55606668	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:55606668G>A	uc010rio.1	+	1	441	c.441G>A	c.(439-441)GTG>GTA	p.V147V		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CCATGCTGGTGGTTGTATTGT	0.448		NA											20	54					0	0	0	0
ENDOD1	23052	broad.mit.edu	37	11	94861543	94861543	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:94861543C>T	uc001pfh.2	+	2	378	c.303C>T	c.(301-303)ATC>ATT	p.I101I		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	101						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TCTTGCAGATCGATGACCCCA	0.517		NA											5	20					0	0	0	0
MMP8	4317	broad.mit.edu	37	11	102593222	102593222	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:102593222G>A	uc001phe.2	-	2	384	c.285C>T	c.(283-285)GAC>GAT	p.D95D	MMP8_uc010rut.1_Silent_p.D30D|MMP8_uc010ruu.1_Silent_p.D72D	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	95	Cysteine switch (By similarity).				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		AACCACCACTGTCAGGCACTC	0.433		NA											26	21					0	0	0	0
C3AR1	719	broad.mit.edu	37	12	8212581	8212581	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:8212581C>T	uc001qtv.1	-	2	293	c.201G>A	c.(199-201)GCG>GCA	p.A67A		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	67	Helical; Name=2; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		AGAGGAGGTCCGCCAAGGTGA	0.592		NA											8	65					0	0	0	0
AICDA	57379	broad.mit.edu	37	12	8758041	8758041	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:8758041G>A	uc001qur.2	-	3	276	c.197C>T	c.(196-198)TCG>TTG	p.S66L	AICDA_uc001qup.1_Missense_Mutation_p.S61L|AICDA_uc001quq.1_Missense_Mutation_p.S61L|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	66					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					GTCCCAGTCCGAGATGTAGCG	0.587		NA							Immune_Deficiency_with_Hyper-IgM				17	126					0	0	0	0
PRB2	653247	broad.mit.edu	37	12	11546807	11546807	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:11546807G>C	uc010shk.1	-	3	240	c.205C>G	c.(205-207)CAA>GAA	p.Q69E		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGGACCTTGAGGCTGGTTG	0.607		NA											67	485					0	0	0	0
PTPRO	5800	broad.mit.edu	37	12	15742398	15742398	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:15742398G>A	uc001rcv.1	+	25	3594	c.3420G>A	c.(3418-3420)GTG>GTA	p.V1140V	PTPRO_uc001rcw.1_Silent_p.V1112V|PTPRO_uc001rcx.1_Silent_p.V329V|PTPRO_uc001rcy.1_Silent_p.V329V|PTPRO_uc001rcz.1_Silent_p.V301V|PTPRO_uc001rda.1_Silent_p.V301V	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1140	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.|Substrate binding (By similarity).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GTGCTGGCGTGGGACGGACAG	0.413		NA											37	102					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847849	43847849	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:43847849G>T	uc010skx.1	-	12	1621	c.1621C>A	c.(1621-1623)CGT>AGT	p.R541S		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	541	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGCCCATGACGGCAATGCTAT	0.368		NA											8	27					0.00448238	0.00459191	1	0
SPRYD3	84926	broad.mit.edu	37	12	53470909	53470909	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:53470909C>T	uc001sbt.1	-	2	181	c.160G>A	c.(160-162)GAT>AAT	p.D54N	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	54	B30.2/SPRY.									central_nervous_system(1)	1						CTTAAAGTATCTCCATCTACA	0.428		NA											22	61					0	0	0	0
STAT6	6778	broad.mit.edu	37	12	57492348	57492348	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:57492348A>G	uc009zpe.2	-	19	2350	c.2099T>C	c.(2098-2100)ATC>ACC	p.I700T	STAT6_uc009zpf.2_Missense_Mutation_p.I700T|STAT6_uc001sna.2_Missense_Mutation_p.I700T|STAT6_uc010srb.1_Missense_Mutation_p.I590T|STAT6_uc010src.1_Missense_Mutation_p.I590T|STAT6_uc010srd.1_Missense_Mutation_p.I590T|STAT6_uc009zpg.2_Missense_Mutation_p.I749T	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	700					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						ATACGGGGGGATGGAGTGAGA	0.547		NA											4	72					0	0	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57994655	57994655	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:57994655G>A	uc001sou.2	+	8	1006	c.875G>A	c.(874-876)CGG>CAG	p.R292Q	PIP4K2C_uc001sot.2_Missense_Mutation_p.R292Q|PIP4K2C_uc010srs.1_Missense_Mutation_p.R274Q|PIP4K2C_uc010srt.1_Missense_Mutation_p.R244Q	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	292	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					GACATCATTCGGGGCTCTGAA	0.562		NA											71	151					0	0	0	0
NEDD1	121441	broad.mit.edu	37	12	97345265	97345265	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:97345265C>T	uc001teu.3	+	15	2206	c.1867C>T	c.(1867-1869)CAT>TAT	p.H623Y	NEDD1_uc001tev.3_Missense_Mutation_p.H623Y|NEDD1_uc010svc.1_Missense_Mutation_p.H534Y|NEDD1_uc001tew.2_Missense_Mutation_p.H630Y|NEDD1_uc001tex.2_Missense_Mutation_p.H534Y	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	623					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TAAACAGTTTCATATGCAACT	0.274		NA											10	30					0	0	0	0
TCP11L2	255394	broad.mit.edu	37	12	106708240	106708240	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:106708240C>T	uc001tln.2	+	3	436	c.262C>T	c.(262-264)CAA>TAA	p.Q88*	TCP11L2_uc001tll.2_Nonsense_Mutation_p.Q88*|TCP11L2_uc001tlm.2_Nonsense_Mutation_p.Q88*	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	88										ovary(3)	3						TGAGAACTTTCAATTGAAACA	0.353		NA											10	44					0	0	0	0
MMP17	4326	broad.mit.edu	37	12	132325377	132325377	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:132325377G>A	uc001ujc.1	+	4	781	c.682G>A	c.(682-684)GAG>AAG	p.E228K	MMP17_uc001ujd.1_Missense_Mutation_p.E144K	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	228					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		TGACGATGACGAGGCCTGGAC	0.711		NA											7	21					0	0	0	0
STARD13	90627	broad.mit.edu	37	13	33684190	33684190	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:33684190G>A	uc001uuw.2	-	12	2993	c.2867C>T	c.(2866-2868)TCT>TTT	p.S956F	STARD13_uc001uuu.2_Missense_Mutation_p.S948F|STARD13_uc001uuv.2_Missense_Mutation_p.S838F|STARD13_uc001uux.2_Missense_Mutation_p.S921F|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	956	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CACCTCCACAGAAGCCTTCCA	0.562		NA									OREG0022359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	21					0	0	0	0
HTR2A	3356	broad.mit.edu	37	13	47469754	47469754	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:47469754G>C	uc001vbq.2	-	1	422	c.288C>G	c.(286-288)ATC>ATG	p.I96M	HTR2A_uc001vbr.2_Intron|HTR2A_uc010acr.2_Missense_Mutation_p.I96M	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	96	Helical; Name=1; (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ACACTGCCATGATGACGAGTA	0.458		NA											20	29					0	0	0	0
PCDH9	5101	broad.mit.edu	37	13	67801807	67801807	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:67801807G>A	uc001vik.2	-	2	1458	c.766C>T	c.(766-768)CAA>TAA	p.Q256*	PCDH9_uc001vil.2_Nonsense_Mutation_p.Q256*|PCDH9_uc010thl.1_Nonsense_Mutation_p.Q256*|PCDH9_uc001vin.3_Nonsense_Mutation_p.Q256*	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	256	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACCTCCACTTGACCCTCTTTA	0.473		NA											24	34					0	0	0	0
GNPNAT1	64841	broad.mit.edu	37	14	53251317	53251317	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:53251317C>T	uc001xab.2	-	2	307	c.52G>A	c.(52-54)GAC>AAC	p.D18N		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	18					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					TGACTCCAGTCCACTTCTTTG	0.373		NA											139	15					0	0	0	0
DIO2	1734	broad.mit.edu	37	14	80669404	80669404	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:80669404G>A	uc010tvq.1	-	4	852	c.450C>T	c.(448-450)TTC>TTT	p.F150F	DIO2_uc010tvp.1_Silent_p.F186F|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Silent_p.F150F|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	150					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCACTGAGGAGAACTCTTCCA	0.557		NA									OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	0	0
GPR65	8477	broad.mit.edu	37	14	88477470	88477470	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:88477470C>T	uc001xvv.2	+	2	809	c.279C>T	c.(277-279)CTC>CTT	p.L93L		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	93	Helical; Name=3; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GTGCTTTTCTCATGTACATGA	0.403		NA											52	97					0	0	0	0
BTBD7	55727	broad.mit.edu	37	14	93709138	93709138	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:93709138G>A	uc001ybo.2	-	11	3206	c.2880C>T	c.(2878-2880)CTC>CTT	p.L960L	BTBD7_uc010aur.2_Silent_p.L485L|BTBD7_uc010two.1_Silent_p.L780L|BTBD7_uc001ybp.2_Silent_p.L609L	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	960										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		TGCGTCTGCTGAGAGCAGGAG	0.478		NA											24	34					0	0	0	0
MGA	23269	broad.mit.edu	37	15	42019556	42019556	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:42019556C>T	uc010ucy.1	+	10	3790	c.3609C>T	c.(3607-3609)CTC>CTT	p.L1203L	MGA_uc010ucz.1_Silent_p.L1203L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1203						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GCAAACTGCTCACTGGAATTA	0.403		NA											43	118					0	0	0	0
PKM2	5315	broad.mit.edu	37	15	72502754	72502754	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:72502754G>A	uc002atx.1	-	4	553	c.312C>T	c.(310-312)CTC>CTT	p.L104L	PKM2_uc002att.1_5'Flank|PKM2_uc002atu.1_5'Flank|PKM2_uc010bit.1_Silent_p.L109L|PKM2_uc010uki.1_Silent_p.L178L|PKM2_uc002atv.1_Silent_p.L139L|PKM2_uc002atw.1_Silent_p.L104L|PKM2_uc002aty.1_Silent_p.L104L|PKM2_uc010ukj.1_Silent_p.L89L|PKM2_uc010ukk.1_Intron|PKM2_uc010biu.1_Silent_p.L125L|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	104					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CGGGCCGGTAGAGGATGGGGT	0.562		NA											59	44					0	0	0	0
NEIL1	79661	broad.mit.edu	37	15	75641389	75641389	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:75641389C>T	uc002bad.2	+	2	649	c.143C>T	c.(142-144)TCA>TTA	p.S48L	NEIL1_uc002bae.2_Missense_Mutation_p.S134L	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	48					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						TACCGCATCTCAGCTTCAGCC	0.657		NA						BER_DNA_glycosylases					40	18					0	0	0	0
TTC23	64927	broad.mit.edu	37	15	99758831	99758831	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:99758831C>T	uc002bur.2	-	7	1074	c.543G>A	c.(541-543)TGG>TGA	p.W181*	TTC23_uc002bus.2_Nonsense_Mutation_p.W181*|TTC23_uc002but.2_Nonsense_Mutation_p.W181*|TTC23_uc002buu.2_Nonsense_Mutation_p.W181*|TTC23_uc002buv.2_Nonsense_Mutation_p.W181*|TTC23_uc002bux.2_Nonsense_Mutation_p.W181*|TTC23_uc002buw.2_Nonsense_Mutation_p.W181*|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Nonsense_Mutation_p.W181*|TTC23_uc010bor.2_Nonsense_Mutation_p.W181*|TTC23_uc002buz.2_Nonsense_Mutation_p.W181*	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	181							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CAATTTCTATCCATTCTTCCT	0.383		NA											90	62					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2376270	2376270	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:2376270C>T	uc002cpy.1	-	5	772	c.60G>A	c.(58-60)CGG>CGA	p.R20R	ABCA3_uc010bsk.1_Silent_p.R20R|ABCA3_uc010bsl.1_Silent_p.R20R|ABCA3_uc002cpz.1_Silent_p.R20R	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	20					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCAGGACCTTCCGCTTCTGGA	0.567		NA											44	25					0	0	0	0
NLRC3	197358	broad.mit.edu	37	16	3614473	3614473	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:3614473C>T	uc010btn.2	-	5	876	c.465G>A	c.(463-465)GTG>GTA	p.V155V		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	155	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CGAAGTGCCTCACCAGGGTGG	0.657		NA											32	13					0	0	0	0
PRR14	78994	broad.mit.edu	37	16	30665567	30665567	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:30665567A>G	uc002dyy.2	+	7	823	c.565A>G	c.(565-567)ATA>GTA	p.I189V	PRR14_uc002dyz.2_Missense_Mutation_p.I34V|PRR14_uc002dza.2_Missense_Mutation_p.I189V|PRR14_uc002dzb.1_Missense_Mutation_p.I3V	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	189	Pro-rich.										0			Colorectal(24;0.103)			GCCCATGAGGATAGTTCGCCA	0.582		NA											15	239					0	0	0	0
CDH16	1014	broad.mit.edu	37	16	66945110	66945110	+	Silent	SNP	C	C	G	rs148829305		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:66945110C>G	uc002eql.2	-	14	1972	c.1899G>C	c.(1897-1899)ACG>ACC	p.T633T	CDH16_uc010cdy.2_Silent_p.T633T|CDH16_uc002eqm.2_Silent_p.T536T	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	633	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCACAAGCACCGTGTAGGTGT	0.612		NA											9	18					0	0	0	0
KIAA0513	9764	broad.mit.edu	37	16	85106591	85106591	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:85106591G>T	uc002fiu.2	+	4	710	c.490G>T	c.(490-492)GTG>TTG	p.V164L	KIAA0513_uc002fis.3_Missense_Mutation_p.V164L|KIAA0513_uc010voj.1_Missense_Mutation_p.V164L|KIAA0513_uc002fit.2_Missense_Mutation_p.V164L	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	164						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTCTTTTGCAGTGGTGCTGTT	0.567		NA											20	65					8.05e-18	8.7e-18	1	0
MED11	400569	broad.mit.edu	37	17	4635163	4635163	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:4635163G>A	uc002fyp.2	+	2	240	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	mediator complex subunit 11	60					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding				0						GCAACACGTGGAGGCGGAGCT	0.607		NA									OREG0024104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	20					0	0	0	0
CAMTA2	23125	broad.mit.edu	37	17	4889259	4889259	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:4889259C>A	uc002gah.1	-	3	159	c.51G>T	c.(49-51)AAG>AAT	p.K17N	CAMTA2_uc010cku.1_Missense_Mutation_p.K40N|CAMTA2_uc002gag.1_Missense_Mutation_p.K40N|CAMTA2_uc002gai.1_Missense_Mutation_p.K19N|CAMTA2_uc010vsu.1_5'UTR	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	17					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGAGAAAGATCTTCAGGTGGT	0.537		NA											26	41					4.6e-10	4.91e-10	1	0
NLRP1	22861	broad.mit.edu	37	17	5440230	5440230	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:5440230C>T	uc002gci.2	-	8	3456	c.2901G>A	c.(2899-2901)ATG>ATA	p.M967I	NLRP1_uc002gcg.1_Missense_Mutation_p.M967I|NLRP1_uc002gck.2_Missense_Mutation_p.M967I|NLRP1_uc002gcj.2_Intron|NLRP1_uc002gcl.2_Intron|NLRP1_uc002gch.3_Missense_Mutation_p.M967I|NLRP1_uc010clh.2_Missense_Mutation_p.M967I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	967	LRR 6.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GTTCCTGCCTCATCTCATCAC	0.622		NA											14	26					0	0	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599185	6599185	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:6599185C>A	uc002gdj.2	-	7	1003	c.915G>T	c.(913-915)GAG>GAT	p.E305D	SLC13A5_uc010vtf.1_Missense_Mutation_p.E305D|SLC13A5_uc010clq.2_Missense_Mutation_p.E262D|SLC13A5_uc002gdk.2_Missense_Mutation_p.E288D|SLC13A5_uc002gdl.1_Missense_Mutation_p.E287D	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	305						integral to membrane	citrate transmembrane transporter activity				0						GCTTCCGGTACTCCTCCTGCA	0.557		NA											33	84					3.21e-22	3.5e-22	1	0
C17orf81	23587	broad.mit.edu	37	17	7156110	7156110	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:7156110G>A	uc002gfg.1	+	3	223	c.116G>A	c.(115-117)CGC>CAC	p.R39H	DULLARD_uc002gfd.2_5'Flank|DULLARD_uc002gfe.2_5'Flank|DULLARD_uc002gff.2_5'Flank|DULLARD_uc002gfc.2_5'Flank|C17orf81_uc002gfj.2_Missense_Mutation_p.R39H|C17orf81_uc010cmb.2_Missense_Mutation_p.R39H|C17orf81_uc002gfh.1_Missense_Mutation_p.R39H|C17orf81_uc002gfi.1_Missense_Mutation_p.R39H|C17orf81_uc002gfk.1_Missense_Mutation_p.R39H|C17orf81_uc002gfl.1_Missense_Mutation_p.R39H	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						TGGGAGGGGCGCAGTCTCTTG	0.587		NA											3	29					0	0	0	0
ALOXE3	59344	broad.mit.edu	37	17	8006700	8006700	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:8006700T>C	uc010cnr.2	-	15	2267	c.1897A>G	c.(1897-1899)AAC>GAC	p.N633D	ALOXE3_uc002gka.2_Missense_Mutation_p.N789D|ALOXE3_uc010vuo.1_Missense_Mutation_p.N765D	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	633	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CAGCTGATGTTCACTTCAGGG	0.557		NA											26	44					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10301955	10301955	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:10301955G>A	uc002gmm.2	-	30	4079	c.3984C>T	c.(3982-3984)GCC>GCT	p.A1328A	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1328	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGGCGTTCTTGGCCTGCAGAA	0.507		NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				30	45					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11696943	11696943	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:11696943G>C	uc002gne.2	+	42	8253	c.8185G>C	c.(8185-8187)GAT>CAT	p.D2729H	DNAH9_uc010coo.2_Missense_Mutation_p.D2023H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2729					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGATCTTTTTGATAAAATCCA	0.323		NA											13	36					0	0	0	0
LRRC48	83450	broad.mit.edu	37	17	17891328	17891328	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:17891328G>A	uc010vxd.1	+	6	739	c.360G>A	c.(358-360)CGG>CGA	p.R120R	LRRC48_uc002gsa.2_Silent_p.R120R|LRRC48_uc010vxc.1_Silent_p.R120R|LRRC48_uc002gsb.2_Silent_p.R120R	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	120	LRR 4.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)					TCAACAACCGGATCTCCAAGA	0.557		NA											4	45					0	0	0	0
PTRF	284119	broad.mit.edu	37	17	40574759	40574759	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:40574759G>A	uc002hzo.2	-	1	516	c.357C>T	c.(355-357)GTC>GTT	p.V119V	PTRF_uc010wgi.1_Silent_p.V101V	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	119					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		TCTTCACGTTGACGCTGACCT	0.642		NA											3	12					0	0	0	0
TUBG2	27175	broad.mit.edu	37	17	40812702	40812702	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:40812702G>A	uc010wgr.1	+	4	632	c.376G>A	c.(376-378)GCA>ACA	p.A126T	TUBG2_uc002iaq.2_5'UTR|TUBG2_uc002iar.2_5'UTR|TUBG2_uc002ias.2_5'UTR|TUBG2_uc002iap.2_5'UTR	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	126					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		AGACCGAGAAGCAGATGGAAG	0.507		NA											10	11					0	0	0	0
DBF4B	80174	broad.mit.edu	37	17	42786685	42786685	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:42786685C>T	uc002ihf.2	+	2	246	c.33C>T	c.(31-33)CTC>CTT	p.L11L	DBF4B_uc002ihd.1_Silent_p.L11L|DBF4B_uc010wjb.1_RNA|DBF4B_uc002ihe.2_5'UTR|DBF4B_uc010wjc.1_5'UTR|DBF4B_uc002ihg.2_5'UTR	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	11					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				ACGATTGCCTCGAGCTGGAGA	0.562		NA											102	244					0	0	0	0
TMC8	147138	broad.mit.edu	37	17	76134712	76134712	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:76134712G>A	uc002jup.2	+	14	2104	c.1722G>A	c.(1720-1722)GTG>GTA	p.V574V	TMC8_uc002juq.2_Silent_p.V351V|TMC8_uc002jur.1_Nonsense_Mutation_p.W24*	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	574	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			CCTGGCAAGTGGTCCCGGAGC	0.657		NA							Epidermodysplasia_Verruciformis_Familial_Clustering_of				27	75					0	0	0	0
RPTOR	57521	broad.mit.edu	37	17	78882729	78882729	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:78882729G>A	uc002jyt.1	+	21	3325	c.2520G>A	c.(2518-2520)AAG>AAA	p.K840K	RPTOR_uc010wug.1_Silent_p.K682K	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	840					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						TCGCCTACAAGGTACGTGCCG	0.587		NA											35	103					0	0	0	0
TBCD	6904	broad.mit.edu	37	17	80863819	80863819	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:80863819G>A	uc002kfz.2	+	20	1942	c.1812G>A	c.(1810-1812)CCG>CCA	p.P604P	TBCD_uc002kfx.1_Silent_p.P587P|TBCD_uc002kfy.1_Silent_p.P604P|TBCD_uc002kgb.1_5'UTR	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	604	HEAT 3.				'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CAGTCTTCCCGAGGCTGCTGT	0.607		NA											8	10					0	0	0	0
USP14	9097	broad.mit.edu	37	18	202939	202939	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:202939C>T	uc002kkf.1	+	11	1152	c.936C>T	c.(934-936)ATC>ATT	p.I312I	USP14_uc002kkg.1_Silent_p.I277I|USP14_uc010wyr.1_Silent_p.I301I	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	312					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CCTTGTATATCAAATCTGTAA	0.333		NA											11	33					0	0	0	0
DLGAP1	9229	broad.mit.edu	37	18	3880020	3880020	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:3880020C>T	uc002kmf.2	-	1	116	c.49G>A	c.(49-51)GAC>AAC	p.D17N	DLGAP1_uc010wyz.1_Missense_Mutation_p.D17N|DLGAP1_uc002kmk.2_Missense_Mutation_p.D17N|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	17					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CAGGCCGAGTCGCAGGTGACC	0.662		NA											14	29					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31325297	31325297	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:31325297A>C	uc010dmg.1	+	12	5540	c.5485A>C	c.(5485-5487)AAG>CAG	p.K1829Q	ASXL3_uc002kxq.2_Missense_Mutation_p.K1536Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CCACCCCAAAAAGAGAGTAGC	0.483		NA											44	173					0	0	0	0
SMAD4	4089	broad.mit.edu	37	18	48584814	48584814	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:48584814C>T	uc010xdp.1	+	7	1430	c.892C>T	c.(892-894)CCC>TCC	p.P298S	SMAD4_uc002lfb.3_Missense_Mutation_p.P143S	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	298	SAD.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GCCGCCCCATCCCGGACATTA	0.428		NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				20	79					0	0	0	0
FECH	2235	broad.mit.edu	37	18	55221509	55221509	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:55221509G>C	uc002lgq.3	-	9	1177	c.1060C>G	c.(1060-1062)CAA>GAA	p.Q354E	FECH_uc002lgp.3_Missense_Mutation_p.Q360E|FECH_uc002lgr.3_Missense_Mutation_p.Q212E	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	354					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding	p.L354L(1)		central_nervous_system(1)	1		Colorectal(73;0.227)				GCTAAAACTTGAGAGTACTCG	0.413		NA											55	224					0	0	0	0
CCBE1	147372	broad.mit.edu	37	18	57147439	57147439	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:57147439G>A	uc002lib.2	-	3	314	c.244C>T	c.(244-246)CTT>TTT	p.L82F		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	82					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CATTGTCCAAGAACAAATTTA	0.284		NA											27	24					0	0	0	0
SERPINB12	89777	broad.mit.edu	37	18	61234050	61234050	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:61234050T>C	uc010xen.1	+	7	1024	c.1024T>C	c.(1024-1026)TCA>CCA	p.S342P	SERPINB12_uc010xeo.1_Missense_Mutation_p.S362P	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	342					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						TTTGTACTTGTCAAAAATTAT	0.448		NA											32	136					0	0	0	0
CREB3L3	84699	broad.mit.edu	37	19	4171739	4171739	+	Missense_Mutation	SNP	G	G	A	rs142789769		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:4171739G>A	uc002lzl.2	+	10	1275	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	CREB3L3_uc002lzm.2_Missense_Mutation_p.E377K|CREB3L3_uc010xib.1_Missense_Mutation_p.E376K|CREB3L3_uc010xic.1_3'UTR	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	387	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCCGACCCGAGGCTGACAC	0.632		NA											42	76					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8619446	8619446	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:8619446C>T	uc002mkg.2	-	4	355	c.241G>A	c.(241-243)GAG>AAG	p.E81K	MYO1F_uc002mkh.2_Missense_Mutation_p.E81K|MYO1F_uc010xkf.1_Missense_Mutation_p.E81K	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	81	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGGGATTCTCATACTGGGCC	0.617		NA											23	47					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9024166	9024166	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:9024166G>A	uc002mkp.2	-	18	37310	c.37106C>T	c.(37105-37107)TCA>TTA	p.S12369L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12371	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGAGTCCCTGAGGTTCTGAG	0.473		NA											5	14					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9056817	9056817	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:9056817G>A	uc002mkp.2	-	3	30833	c.30629C>T	c.(30628-30630)TCA>TTA	p.S10210L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10212	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTGGGGATGATGTTTTTGC	0.468		NA											11	48					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11135091	11135091	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:11135091G>A	uc002mqf.3	+	21	3342	c.3058G>A	c.(3058-3060)GAT>AAT	p.D1020N	SMARCA4_uc010dxp.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxo.2_Missense_Mutation_p.D1020N|SMARCA4_uc002mqg.1_Missense_Mutation_p.D1020N|SMARCA4_uc010dxq.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxr.2_Missense_Mutation_p.D1020N|SMARCA4_uc002mqj.3_Missense_Mutation_p.D1020N|SMARCA4_uc010dxs.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxt.1_Missense_Mutation_p.D240N|SMARCA4_uc002mqh.3_Missense_Mutation_p.D143N|SMARCA4_uc002mqi.1_Missense_Mutation_p.D223N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1020					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTGCTGACTGATGGCTCCGA	0.627		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				15	26					0	0	0	0
NDUFA13	51079	broad.mit.edu	37	19	19637028	19637028	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:19637028C>G	uc010xqy.1	+	2	640	c.381C>G	c.(379-381)ATC>ATG	p.I127M	NDUFA13_uc002nms.2_Missense_Mutation_p.I127M|NDUFA13_uc010xqx.1_Missense_Mutation_p.I127M|YJEFN3_uc002nmt.1_5'Flank|YJEFN3_uc010ecf.1_5'Flank|YJEFN3_uc002nmu.1_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	44	Helical; (Potential).				apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GAACCCTGATCTACGGGCACT	0.642		NA											6	22					0	0	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728762	20728762	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:20728762G>A	uc002npa.2	-	4	427	c.247C>T	c.(247-249)CGA>TGA	p.R83*		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	83					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CAAAGATCTCGGGCAAAATGA	0.328		NA											3	20					0	0	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767646	31767646	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:31767646A>G	uc002nsy.3	-	2	3118	c.3053T>C	c.(3052-3054)ATA>ACA	p.I1018T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1018					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGTTTGTGCTATCTGACTGTT	0.502		NA											17	42					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40354269	40354269	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:40354269G>A	uc002omp.3	-	35	16208	c.16200C>T	c.(16198-16200)TTC>TTT	p.F5400F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5400	VWFD 13.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACCATGGGGAGAAGTCCTGCG	0.557		NA											13	61					0	0	0	0
CEACAM5	1048	broad.mit.edu	37	19	42221507	42221507	+	Silent	SNP	G	G	A	rs149933160		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:42221507G>A	uc002ork.2	+	5	1213	c.1092G>A	c.(1090-1092)CCG>CCA	p.P364P	CEACAM5_uc002orj.1_Silent_p.P363P|CEACAM5_uc002orl.2_Silent_p.P364P	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	364	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AGAGCCTCCCGGTCAGTCCCA	0.512		NA											29	159					0	0	0	0
GRIK5	2901	broad.mit.edu	37	19	42510941	42510941	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:42510941G>A	uc002osj.1	-	15	1928	c.1893C>T	c.(1891-1893)ATC>ATT	p.I631I	GRIK5_uc002osi.1_Silent_p.I203I	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	631	Helical; (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGGAGGAGATGATGATCAAGG	0.647		NA											8	19					0	0	0	0
IRGC	56269	broad.mit.edu	37	19	44222839	44222839	+	Silent	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:44222839C>A	uc002oxh.2	+	2	276	c.129C>A	c.(127-129)CTC>CTA	p.L43L		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	43						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCTCTCACCTCCAGGAGCTGC	0.667		NA											34	48					6.53e-20	7.08e-20	1	0
MARK4	57787	broad.mit.edu	37	19	45769536	45769536	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:45769536G>A	uc002pbb.1	+	7	551	c.546G>A	c.(544-546)CTG>CTA	p.L182L	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.L182L|MARK4_uc002pbc.1_Silent_p.L48L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	182	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACAGGGACCTGAAGGTAAGCC	0.562		NA											61	76					0	0	0	0
ZNF528	84436	broad.mit.edu	37	19	52919487	52919487	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:52919487G>A	uc002pzh.2	+	7	1808	c.1382G>A	c.(1381-1383)GGA>GAA	p.G461E	ZNF528_uc002pzi.2_Missense_Mutation_p.G228E	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		ATCCATAGTGGAGAGAAACCT	0.378		NA											20	76					0	0	0	0
MBOAT7	79143	broad.mit.edu	37	19	54677887	54677887	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:54677887G>A	uc002qdq.2	-	9	1536	c.1270C>T	c.(1270-1272)CGG>TGG	p.R424W	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.R108W|MBOAT7_uc010yem.1_Missense_Mutation_p.R406W|MBOAT7_uc002qdr.2_Missense_Mutation_p.R424W|MBOAT7_uc002qds.2_Missense_Mutation_p.R351W|MBOAT7_uc010yen.1_Missense_Mutation_p.R351W	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	424					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCAGTACCGAAGGGTGTCG	0.647		NA											17	102					0	0	0	0
LILRA5	353514	broad.mit.edu	37	19	54819017	54819017	+	Silent	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:54819017G>C	uc002qfe.2	-	6	849	c.729C>G	c.(727-729)CTC>CTG	p.L243L	LILRA5_uc002qff.2_Silent_p.L231L|LILRA5_uc010yev.1_Silent_p.L243L|LILRA5_uc010yew.1_Silent_p.L231L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	243	Extracellular (Potential).				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGACGGACTGAGGTTATCAG	0.507		NA											10	42					0	0	0	0
NLRP13	126204	broad.mit.edu	37	19	56422029	56422029	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:56422029G>C	uc010ygg.1	-	6	2207	c.2182C>G	c.(2182-2184)CTG>GTG	p.L728V		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	728	LRR 1.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AGCTCATGCAGATTCTCATTT	0.453		NA											32	97					0	0	0	0
ZNF667	63934	broad.mit.edu	37	19	56954105	56954105	+	Missense_Mutation	SNP	C	C	A	rs138160651	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:56954105C>A	uc002qnd.2	-	5	421	c.259G>T	c.(259-261)GGG>TGG	p.G87W	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.G87W|ZNF667_uc010etm.2_Missense_Mutation_p.G30W	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CATTTAGACCCCGAGTCTGAA	0.348		NA											15	77					2.23e-06	2.35e-06	1	0
ZNF71	58491	broad.mit.edu	37	19	57133429	57133429	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:57133429C>T	uc002qnm.3	+	3	1012	c.774C>T	c.(772-774)ATC>ATT	p.I258I		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	258	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		TGCACCTCATCGTGCACCAGC	0.662		NA											16	48					0	0	0	0
CLEC4F	165530	broad.mit.edu	37	2	71046980	71046980	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:71046980C>T	uc002shf.2	-	2	182	c.105G>A	c.(103-105)CCG>CCA	p.P35P	CLEC4F_uc010yqv.1_Silent_p.P35P	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	35	Cytoplasmic (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GAACGAGCCTCGGTATCTTGG	0.567		NA											12	30					0	0	0	0
PCGF1	84759	broad.mit.edu	37	2	74734013	74734013	+	Splice_Site	SNP	T	T	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:74734013T>C	uc002slz.2	-	3	226	c.200_splice	c.e3-1	p.F67_splice	PCGF1_uc002sly.2_Splice_Site	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1						histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						TCTTGCAGACTGCAGGAAAAG	0.527		NA											18	49					0	0	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530936	80530936	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:80530936G>A	uc002sok.1	-	2	279	c.9C>T	c.(7-9)TTC>TTT	p.F3F	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	3						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CGAGCAGCAGGAAATCCATTA	0.557		NA								HNSCC(69;0.2)			11	42					0	0	0	0
GALNT5	11227	broad.mit.edu	37	2	158115563	158115563	+	Silent	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:158115563G>C	uc002tzg.2	+	1	1224	c.969G>C	c.(967-969)GTG>GTC	p.V323V	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	323	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						GCCATCTTGTGATTATAACCA	0.388		NA											27	72					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179449657	179449657	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:179449657C>T	uc010zfg.1	-	259	57231	c.57007G>A	c.(57007-57009)GAT>AAT	p.D19003N	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D12698N|TTN_uc010zfi.1_Missense_Mutation_p.D12631N|TTN_uc010zfj.1_Missense_Mutation_p.D12506N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19930							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGTCTATATCAGAAATGTCA	0.458		NA											24	39					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191874723	191874723	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:191874723G>A	uc002usj.2	-	3	395	c.7C>T	c.(7-9)CAG>TAG	p.Q3*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q3*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q3*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q5*|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	3					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCGTACCACTGAGACATCCTA	0.403		NA											18	22					0	0	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202173910	202173910	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:202173910C>T	uc010ftg.2	-	10	1183	c.739G>A	c.(739-741)GAG>AAG	p.E247K	ALS2CR12_uc002uya.3_Missense_Mutation_p.E247K|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	247					regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TCGAACTTCTCATCCTTCTTC	0.408		NA											43	64					0	0	0	0
NBEAL1	65065	broad.mit.edu	37	2	204009620	204009620	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:204009620G>C	uc002uzt.3	+	31	5392	c.5059G>C	c.(5059-5061)GAA>CAA	p.E1687Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E397Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1687							binding			ovary(1)|skin(1)	2						AGTTTACATTGAAAAATATGT	0.249		NA											6	8					0	0	0	0
TRIB3	57761	broad.mit.edu	37	20	372179	372179	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:372179G>A	uc002wdm.2	+	3	1046	c.540G>A	c.(538-540)CTG>CTA	p.L180L	TRIB3_uc002wdn.2_Silent_p.L207L	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	180	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GTCTGGTCCTGCGTGATCTCA	0.637		NA											8	27					0	0	0	0
C20orf26	26074	broad.mit.edu	37	20	20243630	20243630	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:20243630C>G	uc002wru.2	+	21	2435	c.2359C>G	c.(2359-2361)CAA>GAA	p.Q787E	C20orf26_uc010zse.1_Missense_Mutation_p.Q767E|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Missense_Mutation_p.Q143E	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	787										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TGATATTAGTCAACACCTGAC	0.443		NA											12	31					0	0	0	0
GINS1	9837	broad.mit.edu	37	20	25405913	25405913	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:25405913G>A	uc002wuv.1	+	5	531	c.397G>A	c.(397-399)GGT>AGT	p.G133S	GINS1_uc010zte.1_RNA	NM_021067	NP_066545	Q14691	PSF1_HUMAN	GINS complex subunit 1	133					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm		p.G133R(1)		ovary(1)|central_nervous_system(1)	2						AGGAGATGAAGGTTTGGACAT	0.313		NA											3	38					0	0	0	0
RBL1	5933	broad.mit.edu	37	20	35668562	35668562	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:35668562G>A	uc002xgi.2	-	14	1976	c.1897C>T	c.(1897-1899)CGA>TGA	p.R633*	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Nonsense_Mutation_p.R633*	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	633	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CTACCTCTTCGAAGACTCCCA	0.413		NA											33	83					0	0	0	0
SLC13A3	64849	broad.mit.edu	37	20	45221110	45221110	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:45221110G>C	uc002xsf.1	-	6	891	c.853C>G	c.(853-855)CTT>GTT	p.L285V	SLC13A3_uc010ghn.1_Missense_Mutation_p.L254V|SLC13A3_uc010zxw.1_Intron|SLC13A3_uc002xsg.1_Missense_Mutation_p.L238V|SLC13A3_uc010gho.1_Missense_Mutation_p.L238V|SLC13A3_uc010zxx.1_Missense_Mutation_p.L187V	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	285	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	AACAGCATAAGAGGGAAGGCG	0.522		NA											7	27					0	0	0	0
UMODL1	89766	broad.mit.edu	37	21	43547845	43547845	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr21:43547845C>T	uc002zaf.1	+	20	3594	c.3594C>T	c.(3592-3594)TTC>TTT	p.F1198F	UMODL1_uc002zad.1_Silent_p.F1126F|UMODL1_uc002zae.1_Silent_p.F1254F|UMODL1_uc002zag.1_Silent_p.F1326F|UMODL1_uc002zal.1_Silent_p.F148F|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1198	Extracellular (Potential).|ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGGCCCAGTTCAAGCTGAGGA	0.517		NA											12	47					0	0	0	0
C22orf43	51233	broad.mit.edu	37	22	23974134	23974134	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:23974134G>A	uc002zxf.2	-	1	354	c.77C>T	c.(76-78)TCT>TTT	p.S26F		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	hypothetical protein LOC51233	26										skin(1)	1						ATCAGTATCAGATTCATAACA	0.542		NA											26	66					0	0	0	0
CABIN1	23523	broad.mit.edu	37	22	24483605	24483605	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:24483605C>T	uc002zzi.1	+	23	3591	c.3464C>T	c.(3463-3465)TCA>TTA	p.S1155L	CABIN1_uc002zzj.1_Missense_Mutation_p.S1105L|CABIN1_uc002zzl.1_Missense_Mutation_p.S1155L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1155					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCTTGCACTCATTCGCCTCA	0.587		NA											23	60					0	0	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30722748	30722748	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:30722748G>A	uc011akt.1	-	1	147	c.123C>T	c.(121-123)CTC>CTT	p.L41L	TBC1D10A_uc010gvu.2_Silent_p.L41L|TBC1D10A_uc003ahk.3_Silent_p.L41L	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	41						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGTCAGACCCGAGAGAGCTGA	0.607		NA											12	34					0	0	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059596	11059596	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:11059596C>T	uc010hdq.2	+	4	717	c.306C>T	c.(304-306)TGC>TGT	p.C102C		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	102					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TGCTGGAGTGCTCCCTGGGCC	0.592		NA											43	91					0	0	0	0
HACL1	26061	broad.mit.edu	37	3	15613185	15613185	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:15613185G>A	uc003caf.2	-	12	1245	c.1085C>T	c.(1084-1086)GCT>GTT	p.A362V	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.A335V|HACL1_uc011avt.1_Intron|HACL1_uc003cag.2_Missense_Mutation_p.A6V|HACL1_uc011avu.1_Missense_Mutation_p.A280V|HACL1_uc010hep.2_Missense_Mutation_p.A121V	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	362					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						CTTGGATGCAGCTTCATTGCT	0.323		NA											15	76					0	0	0	0
KCNH8	131096	broad.mit.edu	37	3	19492809	19492809	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:19492809C>T	uc003cbk.1	+	10	1933	c.1738C>T	c.(1738-1740)CGT>TGT	p.R580C	KCNH8_uc011awe.1_3'UTR|KCNH8_uc010hex.1_Missense_Mutation_p.R41C|KCNH8_uc011awf.1_3'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	580	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GTATCTGCTGCGTCAAGGGGA	0.507		NA											29	59					0	0	0	0
CCR3	1232	broad.mit.edu	37	3	46307508	46307508	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:46307508G>C	uc003cpg.1	+	4	1402	c.859G>C	c.(859-861)GAG>CAG	p.E287Q	CCR3_uc003cpi.1_Missense_Mutation_p.E287Q|CCR3_uc003cpj.1_Missense_Mutation_p.E287Q|CCR3_uc003cpk.1_Missense_Mutation_p.E308Q|CCR3_uc010hjb.1_Missense_Mutation_p.E305Q|CCR3_uc003cpl.1_Missense_Mutation_p.E320Q	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	287	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GCTGGTGACAGAGGTGATCGC	0.517		NA											22	27					0	0	0	0
CELSR3	1951	broad.mit.edu	37	3	48689469	48689469	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:48689469C>T	uc003cul.2	-	12	6045	c.5764G>A	c.(5764-5766)GGC>AGC	p.G1922S	CELSR3_uc003cuf.1_Missense_Mutation_p.G1992S|CELSR3_uc010hkg.2_5'UTR	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1922	Extracellular (Potential).|Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGTGGAGCCGAGCCACACC	0.647		NA											3	28					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49694791	49694791	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:49694791G>A	uc003cxe.3	+	5	7916	c.7802G>A	c.(7801-7803)CGA>CAA	p.R2601Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2601	Poly-Arg.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TTGAGTCGGCGACGCCGGGCA	0.647		NA											14	32					0	0	0	0
DOCK3	1795	broad.mit.edu	37	3	51411927	51411927	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:51411927G>A	uc011bds.1	+	50	5344	c.5321G>A	c.(5320-5322)CGC>CAC	p.R1774H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1774						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GATAAGTACCGCCATGCCCGT	0.537		NA											4	11					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868899	97868899	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:97868899A>G	uc003dsg.1	+	1	670	c.670A>G	c.(670-672)ACA>GCA	p.T224A		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTCCTCTATACAATCTTGAA	0.358		NA											12	37					0	0	0	0
IMPG2	50939	broad.mit.edu	37	3	100995541	100995541	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:100995541G>C	uc003duq.1	-	5	753	c.550C>G	c.(550-552)CCA>GCA	p.P184A	IMPG2_uc011bhe.1_Missense_Mutation_p.P47A	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	184	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ACAGGAACTGGAGAAGACAGT	0.333		NA											4	18					0	0	0	0
NR1I2	8856	broad.mit.edu	37	3	119528935	119528935	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:119528935G>A	uc003edj.2	+	3	2064	c.225G>A	c.(223-225)CTG>CTA	p.L75L	NR1I2_uc003edi.2_Silent_p.L75L|NR1I2_uc003edk.2_Silent_p.L114L|NR1I2_uc003edl.2_5'Flank	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	75	Nuclear receptor.|Bipartite nuclear localization signal.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	ACGCCCGGCTGAGGTGCCCCT	0.697		NA											10	58					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121448138	121448138	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:121448138G>A	uc003eei.3	-	4	425	c.299C>T	c.(298-300)GCG>GTG	p.A100V	GOLGB1_uc010hrc.2_Missense_Mutation_p.A100V|GOLGB1_uc003eej.3_Missense_Mutation_p.A61V|GOLGB1_uc011bjm.1_Missense_Mutation_p.A61V|GOLGB1_uc010hrd.1_Missense_Mutation_p.A100V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	100	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTGGCCTTCGCATGAAGTTT	0.363		NA											20	115					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126735460	126735460	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:126735460G>C	uc003ejg.2	+	15	3050	c.3046G>C	c.(3046-3048)GAG>CAG	p.E1016Q		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1039	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CACCAACCCTGAGGTGAAGTA	0.622		NA											21	107					0	0	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642957	127642957	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:127642957G>A	uc010hsr.2	+	1	1056	c.1053G>A	c.(1051-1053)AAG>AAA	p.K351K	KBTBD12_uc003ejy.3_Intron|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Silent_p.K351K	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	351										ovary(1)	1						AAAAGAACAAGAATGTTGAAA	0.348		NA											18	87					0	0	0	0
ARMC8	25852	broad.mit.edu	37	3	137956364	137956364	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:137956364G>T	uc003esa.1	+	10	1051	c.684G>T	c.(682-684)AAG>AAT	p.K228N	ARMC8_uc003erw.2_Missense_Mutation_p.K228N|ARMC8_uc003erx.2_Missense_Mutation_p.K228N|ARMC8_uc003ery.2_Missense_Mutation_p.K200N|ARMC8_uc003erz.2_Missense_Mutation_p.K200N|ARMC8_uc011bmf.1_Missense_Mutation_p.K211N|ARMC8_uc011bmg.1_Missense_Mutation_p.K242N|ARMC8_uc011bmh.1_Missense_Mutation_p.K169N|ARMC8_uc003esb.1_Missense_Mutation_p.K200N|ARMC8_uc003esc.1_5'UTR	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	242	ARM 5.						binding				0						TTTTTGTGAAGATGTTACAGA	0.328		NA											11	66					0.00400662	0.00412002	1	0
RASA2	5922	broad.mit.edu	37	3	141328818	141328818	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:141328818T>G	uc003etz.1	+	23	2429	c.2429T>G	c.(2428-2430)ATT>AGT	p.I810S	RASA2_uc010huq.1_Missense_Mutation_p.I814S|RASA2_uc003eua.1_Missense_Mutation_p.I811S|uc003eub.2_5'Flank	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	810					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TTTAAGACAATTCAGCAAATA	0.363		NA											20	86					0	0	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142607677	142607677	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:142607677G>A	uc003evd.2	-	1	258	c.62C>T	c.(61-63)TCG>TTG	p.S21L		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	21						extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CTGCTGCCGCGAGAGCTGGGT	0.692		NA											3	14					0	0	0	0
CP	1356	broad.mit.edu	37	3	148905959	148905959	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:148905959G>A	uc003ewy.3	-	10	1997	c.1744C>T	c.(1744-1746)CCT>TCT	p.P582S	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.P363S|CP_uc003ewz.2_Missense_Mutation_p.P582S|CP_uc010hvf.1_Missense_Mutation_p.P308S	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	582	Plastocyanin-like 4.|F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AATACTGTAGGAAACAAATAG	0.343		NA											22	82					0	0	0	0
SLC33A1	9197	broad.mit.edu	37	3	155560316	155560316	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:155560316C>T	uc003fan.3	-	2	1249	c.868G>A	c.(868-870)GAA>AAA	p.E290K	SLC33A1_uc003fao.1_Missense_Mutation_p.E290K	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	290	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTTGTGTTTCTTCTTTTACT	0.338		NA											6	46					0	0	0	0
ZBBX	79740	broad.mit.edu	37	3	167033577	167033577	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:167033577G>C	uc003fep.2	-	15	1558	c.1235C>G	c.(1234-1236)CCT>CGT	p.P412R	ZBBX_uc011bpc.1_Missense_Mutation_p.P412R|ZBBX_uc003feq.2_Missense_Mutation_p.P383R	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	412						intracellular	zinc ion binding			ovary(2)	2						AACTTTGTAAGGCACAATATT	0.284		NA											10	41					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	62					0	0	0	0
HTR3D	200909	broad.mit.edu	37	3	183756393	183756393	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:183756393C>T	uc011bqv.1	+	7	1116	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L	HTR3D_uc003fmj.2_Silent_p.L197L|HTR3D_uc011bqu.1_Silent_p.L322L|HTR3D_uc010hxp.2_Silent_p.L151L	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	372	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCCCGGGTCTCACCCCCACCC	0.453		NA											4	30					0	0	0	0
ECE2	9718	broad.mit.edu	37	3	184005699	184005699	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:184005699C>T	uc003fni.3	+	11	1730	c.1692C>T	c.(1690-1692)TTC>TTT	p.F564F	ECE2_uc011brh.1_Silent_p.F417F|ECE2_uc003fnl.3_Silent_p.F492F|ECE2_uc003fnm.3_Silent_p.F446F|ECE2_uc003fnk.3_Silent_p.F417F|ECE2_uc011bri.1_Silent_p.F479F|ECE2_uc010hxv.2_Silent_p.F208F	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	564	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTCCCTCTTCGTGAAGGCCA	0.498		NA											15	58					0	0	0	0
CHRD	8646	broad.mit.edu	37	3	184104374	184104374	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:184104374C>G	uc003fov.2	+	16	2273	c.2027C>G	c.(2026-2028)TCT>TGT	p.S676C	CHRD_uc003fow.2_Missense_Mutation_p.S306C|CHRD_uc003fox.2_Missense_Mutation_p.S676C|CHRD_uc003foy.2_Missense_Mutation_p.S306C|CHRD_uc010hyc.2_Missense_Mutation_p.S266C|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	676					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATACAGCCTCTGCTGCGCCG	0.711		NA											5	10					0	0	0	0
RTP1	132112	broad.mit.edu	37	3	186917628	186917628	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:186917628G>A	uc003frg.2	+	2	592	c.562G>A	c.(562-564)GGA>AGA	p.G188R		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	188	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GCGGCACCGCGGAGAGTTCTG	0.692		NA											10	37					0	0	0	0
C3orf59	151963	broad.mit.edu	37	3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557		NA											14	48					0	0	0	0
LSG1	55341	broad.mit.edu	37	3	194362968	194362968	+	Silent	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:194362968C>G	uc003fui.2	-	14	2121	c.1806G>C	c.(1804-1806)GTG>GTC	p.V602V		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	602					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		TCAAAGCCCTCACATTCTCCT	0.488		NA											14	53					0	0	0	0
C3orf21	152002	broad.mit.edu	37	3	194991445	194991445	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:194991445G>A	uc003fum.3	-	1	451	c.343C>T	c.(343-345)CAG>TAG	p.Q115*		NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	115						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		GCCTTGGCCTGCAGCGCGGCA	0.687		NA											10	22					0	0	0	0
ADRA2C	152	broad.mit.edu	37	4	3768899	3768899	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:3768899C>G	uc003ghm.2	+	1	604	c.566C>G	c.(565-567)TCG>TGG	p.S189W	ADRA2C_uc010icx.2_Missense_Mutation_p.S189W	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	189	Helical; Name=4; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CCGCTGGTCTCGCTCTACCGC	0.677		NA											3	4					0	0	0	0
CLOCK	9575	broad.mit.edu	37	4	56310930	56310930	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:56310930C>A	uc003haz.1	-	20	2488	c.1562G>T	c.(1561-1563)GGA>GTA	p.G521V	CLOCK_uc003hba.1_Missense_Mutation_p.G521V|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	521	Implicated in the circadian rhythmicity (By similarity).				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TTGCATGGCTCCTAATTGAGC	0.338		NA											19	24					6.5e-13	6.98e-13	1	0
SLC4A4	8671	broad.mit.edu	37	4	72397811	72397811	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:72397811C>T	uc003hfy.2	+	17	2316	c.2199C>T	c.(2197-2199)ATC>ATT	p.I733I	SLC4A4_uc010iic.2_Silent_p.I733I|SLC4A4_uc010iib.2_Silent_p.I733I|SLC4A4_uc003hfz.2_Silent_p.I733I|SLC4A4_uc003hgc.3_Silent_p.I689I|SLC4A4_uc010iid.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	733	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TTGCCATTATCTTGTCCATTC	0.378		NA											13	38					0	0	0	0
TIGD2	166815	broad.mit.edu	37	4	90034531	90034531	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:90034531C>G	uc003hsk.2	+	1	564	c.406C>G	c.(406-408)CCA>GCA	p.P136A	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	136	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		Ccatggtattccaaaggctgc	0.194		NA											20	46					0	0	0	0
FGG	2266	broad.mit.edu	37	4	155530881	155530881	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:155530881C>T	uc003ioj.2	-	6	708	c.567G>A	c.(565-567)CAG>CAA	p.Q189Q	FGG_uc003iog.2_Silent_p.Q189Q|FGG_uc003ioh.2_Silent_p.Q197Q|FGG_uc010ipx.2_Silent_p.Q17Q|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Silent_p.Q197Q	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	189	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AAAGCCCGCTCTGTTTAGCTC	0.418		NA											17	57					0	0	0	0
TRIO	7204	broad.mit.edu	37	5	14368963	14368963	+	Silent	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:14368963C>G	uc003jff.2	+	17	3027	c.3021C>G	c.(3019-3021)CTC>CTG	p.L1007L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.L958L|TRIO_uc003jfh.1_Silent_p.L656L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1007					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AAGATCGCCTCAAGCTCGTCA	0.522		NA											10	68					0	0	0	0
PDZD2	23037	broad.mit.edu	37	5	32088427	32088427	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:32088427C>G	uc003jhl.2	+	20	5261	c.4873C>G	c.(4873-4875)CCT>GCT	p.P1625A	PDZD2_uc003jhm.2_Missense_Mutation_p.P1625A	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1625					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TGCCATCTGTCCTGCCTCAGC	0.557		NA											54	124					0	0	0	0
HCN1	348980	broad.mit.edu	37	5	45353208	45353208	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:45353208C>T	uc003jok.2	-	5	1396	c.1371G>A	c.(1369-1371)CTG>CTA	p.L457L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	457	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTACCTCTCTCAGAGGATCAT	0.343		NA											13	32					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71494584	71494584	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:71494584C>T	uc003kbw.3	+	5	5643	c.5402C>T	c.(5401-5403)TCA>TTA	p.S1801L	MAP1B_uc010iyw.1_Missense_Mutation_p.S1818L|MAP1B_uc010iyx.1_Missense_Mutation_p.S1675L|MAP1B_uc010iyy.1_Missense_Mutation_p.S1675L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1801						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCTACTTTTTCAGATTCTACC	0.473		NA											13	63					0	0	0	0
ENC1	8507	broad.mit.edu	37	5	73931590	73931590	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:73931590G>C	uc003kdc.3	-	2	1852	c.721C>G	c.(721-723)CTG>GTG	p.L241V	ENC1_uc011css.1_Missense_Mutation_p.L168V	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	241					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		ATGGCTGGCAGAAGTGCCAGC	0.483		NA											22	65					0	0	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855801	79855801	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:79855801G>T	uc010jam.2	-	4	388	c.38C>A	c.(37-39)TCC>TAC	p.S13Y	ANKRD34B_uc003kgw.2_Missense_Mutation_p.S13Y|ANKRD34B_uc010jan.2_Missense_Mutation_p.S13Y	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	13	ANK 1.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		TTTGATCAAGGAATTTCCTTC	0.458		NA											15	58					1.57e-10	1.69e-10	1	0
XRCC4	7518	broad.mit.edu	37	5	82491695	82491695	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:82491695A>C	uc003kib.2	+	4	550	c.422A>C	c.(421-423)AAT>ACT	p.N141T	XRCC4_uc003kia.1_Missense_Mutation_p.N141T|XRCC4_uc003kid.2_Missense_Mutation_p.N141T|XRCC4_uc003kic.2_Missense_Mutation_p.N141T|XRCC4_uc003kie.2_Missense_Mutation_p.N141T|XRCC4_uc003kif.1_Missense_Mutation_p.N141T	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	141	Potential.				DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		CAAGCCAAAAATGAGCACCTG	0.403		NA						NHEJ					10	72					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89943367	89943367	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:89943367C>T	uc003kju.2	+	17	3171	c.3075C>T	c.(3073-3075)CTC>CTT	p.L1025L	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1025	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTACAGTTCTCAGAAATGGAT	0.433		NA											20	40					0	0	0	0
TTC37	9652	broad.mit.edu	37	5	94876457	94876457	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:94876457C>T	uc003klb.2	-	8	750	c.480G>A	c.(478-480)TGG>TGA	p.W160*	TTC37_uc010jbf.1_Nonsense_Mutation_p.W112*	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	160							binding			ovary(3)|pancreas(1)	4						TCAATTTTCTCCATAGTTGAT	0.378		NA											27	65					0	0	0	0
RAD50	10111	broad.mit.edu	37	5	131915735	131915735	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:131915735G>A	uc003kxi.2	+	5	1120	c.733G>A	c.(733-735)GAG>AAG	p.E245K	RAD50_uc003kxg.1_Missense_Mutation_p.E146K|RAD50_uc003kxh.2_Missense_Mutation_p.E106K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	245	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAAATCCTATGAGAATGAACT	0.229		NA						Homologous_recombination					33	66					0	0	0	0
EGR1	1958	broad.mit.edu	37	5	137803417	137803417	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:137803417G>A	uc003ldb.1	+	2	1549	c.1279G>A	c.(1279-1281)GAC>AAC	p.D427N	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	427					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAAGAAAGCAGACAAAAGTGT	0.323		NA											12	32					0	0	0	0
PSD2	84249	broad.mit.edu	37	5	139192996	139192996	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:139192996C>T	uc003leu.1	+	3	679	c.474C>T	c.(472-474)CTC>CTT	p.L158L		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	158					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGCCTCGACTCCCTAG	0.652		NA											27	59					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735361	140735361	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:140735361C>T	uc003ljq.1	+	1	594	c.594C>T	c.(592-594)CGC>CGT	p.R198R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.R198R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGGAACGCGCTCTAGATC	0.567		NA											7	8					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811312	140811312	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:140811312C>T	uc003lkt.1	+	1	1155	c.986C>T	c.(985-987)GCG>GTG	p.A329V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A329V	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATTCTGCGCGAGCCAAA	0.507		NA											23	55					0	0	0	0
SPRY4	81848	broad.mit.edu	37	5	141694650	141694650	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:141694650G>A	uc003lml.2	-	2	283	c.24C>T	c.(22-24)AGC>AGT	p.S8S	SPRY4_uc010jgi.1_Silent_p.S31S	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	8					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAAGGGGGCGCTCTGTGGGA	0.632		NA							Testicular_Cancer_Familial_Clustering_of				10	21					0	0	0	0
EBF1	1879	broad.mit.edu	37	5	158140039	158140039	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:158140039C>T	uc010jip.2	-	13	1610	c.1308G>A	c.(1306-1308)GTG>GTA	p.V436V	EBF1_uc011ddw.1_Silent_p.V304V|EBF1_uc011ddx.1_Silent_p.V437V|EBF1_uc003lxl.3_Silent_p.V405V	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	436					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAACGAATTCACGCCCATCA	0.577		NA	T	HMGA2	lipoma								22	45					0	0	0	0
ODZ2	57451	broad.mit.edu	37	5	167645222	167645222	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:167645222G>A	uc010jjd.2	+	23	4299	c.4299G>A	c.(4297-4299)GAG>GAA	p.E1433E	ODZ2_uc003lzr.3_Silent_p.E1203E|ODZ2_uc003lzt.3_Silent_p.E806E|ODZ2_uc010jje.2_Silent_p.E697E	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GAATCACCGAGAACCACCAAG	0.507		NA											43	110					0	0	0	0
SERPINB1	1992	broad.mit.edu	37	6	2838863	2838863	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:2838863C>T	uc003mub.2	-	3	270	c.226G>A	c.(226-228)GAT>AAT	p.D76N	SERPINB1_uc003muc.2_5'UTR	NM_030666	NP_109591	P30740	ILEU_HUMAN	serine (or cysteine) proteinase inhibitor, clade	76					regulation of proteolysis	cytoplasm|extracellular space	serine-type endopeptidase inhibitor activity			breast(4)|ovary(1)	5	Ovarian(93;0.0412)			OV - Ovarian serous cystadenocarcinoma(45;0.0717)		TTGTTGATATCAGCATTCAGA	0.338		NA											12	38					0	0	0	0
ZNF184	7738	broad.mit.edu	37	6	27419348	27419348	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:27419348G>A	uc003njj.2	-	5	2801	c.1990C>T	c.(1990-1992)CAC>TAC	p.H664Y	ZNF184_uc010jqv.2_Missense_Mutation_p.H664Y|ZNF184_uc003nji.2_Missense_Mutation_p.H664Y	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	664	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCCCAGTGTGAATTCGTTGA	0.423		NA											24	45					0	0	0	0
ZNF184	7738	broad.mit.edu	37	6	27419878	27419878	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:27419878G>A	uc003njj.2	-	5	2271	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L	ZNF184_uc010jqv.2_Missense_Mutation_p.S487L|ZNF184_uc003nji.2_Missense_Mutation_p.S487L	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	487	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTAAGGGATGAGCAGTAACT	0.403		NA											25	59					0	0	0	0
GNL1	2794	broad.mit.edu	37	6	30521243	30521243	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:30521243G>A	uc003nqh.2	-	6	1720	c.692C>T	c.(691-693)CCG>CTG	p.P231L	GNL1_uc011dmi.1_Missense_Mutation_p.P93L|GNL1_uc011dmj.1_Missense_Mutation_p.P229L|GNL1_uc011dmk.1_Intron	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	231					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						AAGAGCTGGCGGGGCCAGATC	0.542		NA											30	82					0	0	0	0
SPDEF	25803	broad.mit.edu	37	6	34507128	34507128	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:34507128G>A	uc003ojq.1	-	5	1143	c.728C>T	c.(727-729)TCA>TTA	p.S243L	SPDEF_uc011dsq.1_Missense_Mutation_p.S227L	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	243					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						CCCGGAGCATGATGAGTCCAC	0.622		NA											42	126					0	0	0	0
FAM135A	57579	broad.mit.edu	37	6	71190648	71190648	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:71190648C>T	uc003pfj.2	+	7	720	c.587C>T	c.(586-588)CCA>CTA	p.P196L	FAM135A_uc003pfi.2_Missense_Mutation_p.P196L|FAM135A_uc003pfh.2_Missense_Mutation_p.P153L|FAM135A_uc003pfk.2_Missense_Mutation_p.P196L|FAM135A_uc003pfl.2_Missense_Mutation_p.P33L|FAM135A_uc003pfm.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	196										central_nervous_system(1)	1						AGAAATGCACCAGCACAAAAC	0.358		NA											14	37					0	0	0	0
HACE1	57531	broad.mit.edu	37	6	105224986	105224986	+	Splice_Site	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:105224986C>G	uc003pqu.1	-	16	1956	c.1679_splice	c.e16-1	p.D560_splice	HACE1_uc010kcy.1_Splice_Site_p.D42_splice|HACE1_uc010kcz.1_Intron|HACE1_uc010kcx.1_Intron|HACE1_uc003pqt.1_Splice_Site_p.D213_splice	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAAATAGAATCTAAATATGTA	0.328		NA											10	15					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112438963	112438963	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:112438963C>G	uc003pvu.2	-	35	5269	c.4960G>C	c.(4960-4962)GAA>CAA	p.E1654Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E1647Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E1647Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1654	Laminin G-like 5.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TATCCTCCTTCTGTTGAAAAG	0.458		NA											33	94					0	0	0	0
SYTL3	94120	broad.mit.edu	37	6	159129394	159129394	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:159129394G>A	uc003qrp.2	+	7	731	c.487G>A	c.(487-489)GAG>AAG	p.E163K	SYTL3_uc011efp.1_Missense_Mutation_p.E163K|SYTL3_uc003qro.2_Missense_Mutation_p.E163K|SYTL3_uc003qrq.2_Missense_Mutation_p.E163K|SYTL3_uc003qrr.2_Missense_Mutation_p.E163K|SYTL3_uc003qrs.2_Missense_Mutation_p.E163K|SYTL3_uc011efq.1_Intron	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	163					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCCTGTCAGCGAGAGCCAGTG	0.517		NA											18	45					0	0	0	0
HECW1	23072	broad.mit.edu	37	7	43483921	43483921	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:43483921G>A	uc003tid.1	+	11	1755	c.1150G>A	c.(1150-1152)GCA>ACA	p.A384T	HECW1_uc011kbi.1_Missense_Mutation_p.A384T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	384					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TCGGTCTGAGGCACCAGAGTC	0.577		NA											17	29					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45753517	45753517	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:45753517G>A	uc003tne.3	+	20	3301	c.3283G>A	c.(3283-3285)GTC>ATC	p.V1095I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1095	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CATGCCTGGCGTCTCAGTCAG	0.652		NA											19	57					0	0	0	0
COBL	23242	broad.mit.edu	37	7	51096125	51096125	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:51096125C>T	uc003tpr.3	-	10	2853	c.2668G>A	c.(2668-2670)GGT>AGT	p.G890S	COBL_uc003tps.2_Missense_Mutation_p.G947S|COBL_uc011kcl.1_Missense_Mutation_p.G890S|COBL_uc003tpp.3_Missense_Mutation_p.G676S|COBL_uc003tpq.3_Missense_Mutation_p.G831S|COBL_uc003tpo.3_Missense_Mutation_p.G432S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	890										skin(3)|ovary(2)	5	Glioma(55;0.08)					TCGGCATAACCGTGTGGCCTC	0.562		NA											17	54					0	0	0	0
ZNF716	441234	broad.mit.edu	37	7	57529035	57529035	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:57529035C>T	uc011kdi.1	+	4	980	c.868C>T	c.(868-870)CAT>TAT	p.H290Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CAAGAGAATTCATACTGGAGA	0.408		NA											9	17					0	0	0	0
HGF	3082	broad.mit.edu	37	7	81374353	81374353	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:81374353G>A	uc003uhl.2	-	6	874	c.709C>T	c.(709-711)CAT>TAT	p.H237Y	HGF_uc003uhm.2_Missense_Mutation_p.H232Y|HGF_uc003uhn.1_Missense_Mutation_p.H237Y|HGF_uc003uho.1_Missense_Mutation_p.H232Y	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	237	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GGTGTCTGATGATCCCAGCGC	0.378		NA											16	39					0	0	0	0
PEX1	5189	broad.mit.edu	37	7	92131331	92131331	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:92131331C>G	uc003uly.2	-	14	2385	c.2289G>C	c.(2287-2289)AAG>AAC	p.K763N	PEX1_uc011khr.1_Missense_Mutation_p.K555N|PEX1_uc010ley.2_Missense_Mutation_p.K706N|PEX1_uc011khs.1_Missense_Mutation_p.K441N|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	763					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GATCGGTGAACTTGTTTATAT	0.353		NA											58	170					0	0	0	0
AP4M1	9179	broad.mit.edu	37	7	99704400	99704400	+	Silent	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:99704400C>G	uc003utb.3	+	15	1465	c.1257C>G	c.(1255-1257)CTC>CTG	p.L419L	AP4M1_uc010lgl.1_Silent_p.L394L|AP4M1_uc003utc.3_Silent_p.L426L|AP4M1_uc010lgm.2_Silent_p.L291L|AP4M1_uc003utd.2_Silent_p.L419L|AP4M1_uc011kjh.1_Silent_p.L371L|AP4M1_uc003ute.3_Silent_p.L194L|AP4M1_uc003utf.3_Silent_p.L291L	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	419	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCTCTGGCCTCCAGGTCCGAT	0.652		NA											9	55					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103294652	103294652	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:103294652C>G	uc003vca.2	-	13	1602	c.1442G>C	c.(1441-1443)GGA>GCA	p.G481A	RELN_uc010liz.2_Missense_Mutation_p.G481A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	481					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACAAATTCCTCCTGCACAAAA	0.318		NA											11	34					0	0	0	0
TMEM168	64418	broad.mit.edu	37	7	112412901	112412901	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:112412901C>G	uc003vgn.2	-	4	1873	c.1481G>C	c.(1480-1482)AGA>ACA	p.R494T	TMEM168_uc010lju.2_Missense_Mutation_p.R494T|TMEM168_uc011kmr.1_Missense_Mutation_p.R110T	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	494						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						CGTATCATGTCTGGGTCCATC	0.443		NA											21	51					0	0	0	0
FEZF1	389549	broad.mit.edu	37	7	121944204	121944205	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:121944204_121944205CC>TT	uc003vkd.2	-	1	361_362	c.287_288GG>AA	c.(286-288)CGG>CAA	p.R96Q	FEZF1_uc003vkc.2_Missense_Mutation_p.R96Q|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	96					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GACTGGCCTTCCGCGGCTCGGA	0.569		NA											6	13					0	0	0	0
FLNC	2318	broad.mit.edu	37	7	128483349	128483349	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:128483349G>A	uc003vnz.3	+	17	2826	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K	FLNC_uc003voa.3_Missense_Mutation_p.E873K	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	873	Filamin 7.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGTCAAGGCCGAGGGCCCTGG	0.642		NA											4	9					0	0	0	0
KLF14	136259	broad.mit.edu	37	7	130417929	130417929	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:130417929G>A	uc003vqk.1	-	1	932	c.932C>T	c.(931-933)TCC>TTC	p.S311F		NM_138693	NP_619638	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(18;0.0435)					GCCGGGACCGGAGCCGGAGGC	0.627		NA											3	14					0	0	0	0
EPHA1	2041	broad.mit.edu	37	7	143090949	143090949	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:143090949C>G	uc003wcz.2	-	16	2598	c.2511G>C	c.(2509-2511)AAG>AAC	p.K837N		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	837	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CCTCAATGCTCTTCATAACCT	0.577		NA											23	43					0	0	0	0
SNTG1	54212	broad.mit.edu	37	8	51621528	51621528	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:51621528C>T	uc010lxy.1	+	18	1645	c.1274C>T	c.(1273-1275)GCT>GTT	p.A425V	SNTG1_uc003xqs.1_Missense_Mutation_p.A425V|SNTG1_uc010lxz.1_Missense_Mutation_p.A425V|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	425					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGCTTTGATGCTGCAACAAAG	0.378		NA											18	42					0	0	0	0
TRIM55	84675	broad.mit.edu	37	8	67066571	67066571	+	Splice_Site	SNP	T	T	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:67066571T>G	uc003xvv.2	+	9	1750	c.1524_splice	c.e9+2	p.Q508_splice	TRIM55_uc003xvu.2_Splice_Site_p.Q508_splice|TRIM55_uc003xvw.2_Intron|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			ACTTCTCAGGTTAGTGATGAT	0.542		NA											10	27					0	0	0	0
NCOA2	10499	broad.mit.edu	37	8	71039096	71039096	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:71039096G>A	uc003xyn.1	-	19	4030	c.3868C>T	c.(3868-3870)CGG>TGG	p.R1290W	NCOA2_uc011lfb.1_Missense_Mutation_p.R378W	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1290					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TGGGGAATCCGAGGGTTGCTC	0.502		NA	T	RUNXBP2	AML								4	23					0	0	0	0
CNBD1	168975	broad.mit.edu	37	8	88363940	88363940	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:88363940C>G	uc003ydy.2	+	9	1118	c.1070C>G	c.(1069-1071)TCT>TGT	p.S357C		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	357	cNMP.									ovary(3)	3						AATATAATTTCTTTTGTGGGT	0.274		NA											3	7					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113569178	113569178	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:113569178C>T	uc003ynu.2	-	25	4207	c.4048G>A	c.(4048-4050)GAA>AAA	p.E1350K	CSMD3_uc003yns.2_Missense_Mutation_p.E622K|CSMD3_uc003ynt.2_Missense_Mutation_p.E1310K|CSMD3_uc011lhx.1_Missense_Mutation_p.E1246K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1350	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTGAGAGTTCAAAACCTGGG	0.358		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	22					0	0	0	0
COL14A1	7373	broad.mit.edu	37	8	121354670	121354670	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:121354670G>A	uc003yox.2	+	44	5138	c.4873G>A	c.(4873-4875)GAA>AAA	p.E1625K	COL14A1_uc003yoz.2_Missense_Mutation_p.E590K	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1625					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCAAGTATGCGAACAGCTCAT	0.478		NA											14	33					0	0	0	0
GSDMC	56169	broad.mit.edu	37	8	130774940	130774941	+	Missense_Mutation	DNP	TT	TT	GC			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:130774940_130774941TT>GC	uc003ysr.2	-	5	1489_1490	c.607_608AA>GC	c.(607-609)AAG>GCG	p.K203A		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	203						mitochondrion				ovary(2)|skin(1)	3						AGTCAGCGCCTTCTTCTTCACT	0.416		NA											50	113					0	0	0	0
ARC	23237	broad.mit.edu	37	8	143695106	143695106	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:143695106G>A	uc003ywn.1	-	1	728	c.527C>T	c.(526-528)CCG>CTG	p.P176L		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	176					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				GGCTGGGGGCGGGGTGATGGC	0.746		NA											5	4					0	0	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154328	145154328	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:145154328G>A	uc003zba.2	-	6	1258	c.774C>T	c.(772-774)TTC>TTT	p.F258F	SHARPIN_uc003zbb.2_RNA	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	258	Ubiquitin-like.|Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGAGCTCTGAGAACACCTGTG	0.652		NA											9	27					0	0	0	0
KIFC2	90990	broad.mit.edu	37	8	145692461	145692461	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:145692461G>A	uc003zcz.2	+	3	363	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	100					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGGGGCGGAAGAGAGCTGCGG	0.746		NA									OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7					0	0	0	0
CCIN	881	broad.mit.edu	37	9	36169709	36169709	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:36169709C>T	uc003zzb.3	+	1	321	c.210C>T	c.(208-210)ATC>ATT	p.I70I		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	70	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			AGCTTTTCATCACCATTGACA	0.532		NA											8	25					0	0	0	0
VPS13A	23230	broad.mit.edu	37	9	79936594	79936594	+	Missense_Mutation	SNP	G	G	A	rs145524733		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:79936594G>A	uc004akr.2	+	44	6022	c.5762G>A	c.(5761-5763)CGA>CAA	p.R1921Q	VPS13A_uc004akp.3_Missense_Mutation_p.R1921Q|VPS13A_uc004akq.3_Missense_Mutation_p.R1921Q|VPS13A_uc004aks.2_Missense_Mutation_p.R1882Q|VPS13A_uc004akt.2_Missense_Mutation_p.R261Q	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1921					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GATTATATCCGAACCAAGGAC	0.353		NA											13	39					0	0	0	0
SLC28A3	64078	broad.mit.edu	37	9	86912933	86912933	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:86912933A>C	uc010mpz.2	-	7	796	c.671T>G	c.(670-672)GTT>GGT	p.V224G	SLC28A3_uc011lsy.1_Missense_Mutation_p.V155G|SLC28A3_uc004anu.1_Missense_Mutation_p.V224G|SLC28A3_uc010mqb.2_Missense_Mutation_p.V155G	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	224	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCTCCAGTAAACCTATACAGA	0.418		NA											8	64					0	0	0	0
LCN2	3934	broad.mit.edu	37	9	130914289	130914289	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:130914289A>C	uc004bto.1	+	4	533	c.460A>C	c.(460-462)AAG>CAG	p.K154Q	LCN2_uc011map.1_Missense_Mutation_p.K154Q	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	154		Catecholate-type ferric siderophore.			apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						GGAGTACTTCAAGATCACCCT	0.547		NA											24	79					0	0	0	0
SYAP1	94056	broad.mit.edu	37	X	16775366	16775366	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:16775366G>A	uc004cxp.2	+	8	958	c.865G>A	c.(865-867)GAT>AAT	p.D289N	SYAP1_uc004cxo.2_Missense_Mutation_p.D289N|SYAP1_uc011miv.1_Missense_Mutation_p.D255N	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	289										skin(1)	1	Hepatocellular(33;0.0997)					AAATCAGGAAGATCTAAGGAA	0.398		NA											39	29					0	0	0	0
TAB3	257397	broad.mit.edu	37	X	30873379	30873379	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:30873379G>A	uc004dcj.2	-	6	1066	c.403C>T	c.(403-405)CCC>TCC	p.P135S	TAB3_uc004dck.2_Missense_Mutation_p.P135S|TAB3_uc010ngl.2_Missense_Mutation_p.P135S	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	135					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TTGTAGTTGGGAGTAGCAGCA	0.443		NA											28	15					0	0	0	0
GATA1	2623	broad.mit.edu	37	X	48650432	48650432	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:48650432G>A	uc004dkq.3	+	3	493	c.402G>A	c.(400-402)GAG>GAA	p.E134E		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	134					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GCTTCCTGGAGACTTTGAAGA	0.612		NA	Mis|F		megakaryoblastic leukemia of Downs Syndrome								15	14					0	0	0	0
KCND1	3750	broad.mit.edu	37	X	48826593	48826593	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:48826593G>A	uc004dlx.1	-	1	1659	c.86C>T	c.(85-87)CCG>CTG	p.P29L	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	29	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						CCCCGGTGCCGGGGGCAGGGG	0.662		NA											3	8					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53560990	53560990	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:53560990G>A	uc004dsp.2	-	83	13402	c.13000C>T	c.(13000-13002)CGC>TGC	p.R4334C	HUWE1_uc004dsn.2_Missense_Mutation_p.R3142C	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4334	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GAAGGCAGGCGATCTGTGGAC	0.493		NA											23	19					0	0	0	0
ITM2A	9452	broad.mit.edu	37	X	78616833	78616833	+	Silent	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:78616833G>A	uc004edh.2	-	5	1031	c.696C>T	c.(694-696)CTC>CTT	p.L232L	ITM2A_uc011mqr.1_Silent_p.L188L	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	232						integral to membrane	protein binding			lung(2)	2						TACCCAGCAAGAGGTCTCTGC	0.433		NA											31	25					0	0	0	0
TRMT2B	79979	broad.mit.edu	37	X	100290613	100290613	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:100290613G>C	uc004egq.2	-	6	897	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egs.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egt.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egu.2_Missense_Mutation_p.Q81E|TRMT2B_uc004egv.2_Missense_Mutation_p.Q155E	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	200							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						TGCGCCACTTGACTGTGTTTC	0.393		NA											24	31					0	0	0	0
GPRASP2	114928	broad.mit.edu	37	X	101971015	101971015	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:101971015C>G	uc004ejk.2	+	4	2552	c.1218C>G	c.(1216-1218)ATC>ATG	p.I406M	GPRASP2_uc004ejl.2_Missense_Mutation_p.I406M|GPRASP2_uc004ejm.2_Missense_Mutation_p.I406M|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	406						cytoplasm	protein binding			ovary(1)	1						CTTCAGCAATCTGTGAATCTG	0.547		NA											3	37					0	0	0	0
ELF4	2000	broad.mit.edu	37	X	129205093	129205093	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:129205093G>C	uc004evd.3	-	7	1116	c.731C>G	c.(730-732)TCC>TGC	p.S244C	ELF4_uc004eve.3_Missense_Mutation_p.S244C	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	244	ETS.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CACAGCTTTGGAGTCCACCAG	0.522		NA	T	ERG	AML								63	40					0	0	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130220635	130220635	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:130220635T>A	uc004evz.2	+	11	1827	c.1482T>A	c.(1480-1482)GAT>GAA	p.D494E	ARHGAP36_uc004ewa.2_Missense_Mutation_p.D482E|ARHGAP36_uc004ewb.2_Missense_Mutation_p.D463E|ARHGAP36_uc004ewc.2_Missense_Mutation_p.D358E	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	494					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						AGCCTTCTGATGAAGGTCAGT	0.537		NA											7	32					0	0	0	0
GPC4	2239	broad.mit.edu	37	X	132440099	132440099	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:132440099C>T	uc004exc.1	-	5	1173	c.961G>A	c.(961-963)GAT>AAT	p.D321N	GPC4_uc011mvg.1_Missense_Mutation_p.D251N	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	321					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					ATAATAGCATCAGAAATCTTC	0.488		NA											41	35					0	0	0	0
GPC3	2719	broad.mit.edu	37	X	132795857	132795857	+	Silent	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:132795857C>T	uc004exe.1	-	6	1504	c.1314G>A	c.(1312-1314)AGG>AGA	p.R438R	GPC3_uc004exd.1_Silent_p.R310R|GPC3_uc010nrn.1_Silent_p.R461R|GPC3_uc011mvh.1_Silent_p.R422R|GPC3_uc010nro.1_Silent_p.R384R	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	438						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCATTCCATTCCTTGCTGCCT	0.413		NA	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				15	23					0	0	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291674	141291674	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:141291674C>T	uc004fbu.1	-	3	448	c.100G>A	c.(100-102)GAG>AAG	p.E34K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	34	Poly-Glu.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTTCCTCATCTGTGGGA	0.522		NA								HNSCC(46;0.14)			45	41					0	0	0	0
HCFC1	3054	broad.mit.edu	37	X	153215717	153215717	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:153215717G>A	uc004fjp.2	-	24	6509	c.5981C>T	c.(5980-5982)GCC>GTC	p.A1994V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1994					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACTTGTGTGGCCGGGCCATA	0.622		NA											26	11					0	0	0	0
CASZ1	54897	broad.mit.edu	37	1	10715845	10715857	+	Frame_Shift_Del	DEL	ATCACGTCCTGCT	ATCACGTCCTGCT	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:10715845_10715857delATCACGTCCTGCT	uc001aro.2	-	9	1834_1846	c.1514_1526delAGCAGGACGTGAT	c.(1513-1527)AAGCAGGACGTGATCfs	p.K505fs	CASZ1_uc001arp.1_Frame_Shift_Del_p.K505fs|CASZ1_uc009vmx.2_Frame_Shift_Del_p.K529fs	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	505_509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GTAGTGGCGGATCACGTCCTGCTTACTCGTGAA	0.629		NA											17	31	---	---	---	---	NA	NA	NA	NA
MACF1	23499	broad.mit.edu	37	1	39801943	39801943	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:39801943delA	uc010oiu.1	+	1	5134	c.5003delA	c.(5002-5004)GAAfs	p.E1668fs	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3233					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCAAATCTGAAATAGCAACA	0.398		NA											7	102	---	---	---	---	NA	NA	NA	NA
ANKRD30A	91074	broad.mit.edu	37	10	37482137	37482137	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:37482137delT	uc001iza.1	+	27	2496	c.2397delT	c.(2395-2397)TCTfs	p.S799fs		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	855						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TGAAAGTTTCTATTCCAACTA	0.264		NA											12	72	---	---	---	---	NA	NA	NA	NA
DNAH2	146754	broad.mit.edu	37	17	7734149	7734149	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:7734149delT	uc002giu.1	+	78	12233	c.12219delT	c.(12217-12219)ACTfs	p.T4073fs	DNAH2_uc010cnm.1_Frame_Shift_Del_p.T1011fs	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4073	TPR 4.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCTATCAACTCCCTTCCACC	0.567		NA											13	21	---	---	---	---	NA	NA	NA	NA
SERPINB2	5055	broad.mit.edu	37	18	61562580	61562581	+	Frame_Shift_Del	DEL	AG	AG	-	rs149564761	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:61562580_61562581delAG	uc010xeu.1	+	4	584_585	c.251_252delAG	c.(250-252)CAGfs	p.Q84fs	SERPINB2_uc002ljo.2_Frame_Shift_Del_p.Q84fs|SERPINB2_uc010dqh.2_Frame_Shift_Del_p.Q14fs|SERPINB2_uc002ljp.1_5'Flank|SERPINB2_uc002ljq.1_5'Flank	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	84					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	TTCATGCAGCAGATCCAGAAGG	0.416		NA											14	229	---	---	---	---	NA	NA	NA	NA
NCKAP5	344148	broad.mit.edu	37	2	133543004	133543004	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:133543004delG	uc002ttp.2	-	14	1754	c.1380delC	c.(1378-1380)CCCfs	p.P460fs	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	460							protein binding				0						GTTCCTTGCAGGGGCTCCCCA	0.478		NA											14	49	---	---	---	---	NA	NA	NA	NA
GALNT5	11227	broad.mit.edu	37	2	158115183	158115183	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:158115183delC	uc002tzg.2	+	1	844	c.589delC	c.(589-591)CCCfs	p.P197fs	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	197	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AAAACAGGAGCCCCGGAAGAG	0.473		NA											11	36	---	---	---	---	NA	NA	NA	NA
MARCH4	57574	broad.mit.edu	37	2	217234943	217234945	+	In_Frame_Del	DEL	CAC	CAC	-	rs145386484		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:217234943_217234945delCAC	uc002vgb.2	-	1	1806_1808	c.39_41delGTG	c.(37-42)TGGTGC>TGC	p.W13del		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	13						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGAGCAGCAGCACCACCACCACC	0.616		NA											2	4	---	---	---	---	NA	NA	NA	NA
CAMKV	79012	broad.mit.edu	37	3	49898901	49898907	+	Frame_Shift_Del	DEL	AGTGCAA	AGTGCAA	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:49898901_49898907delAGTGCAA	uc003cxt.1	-	5	599_605	c.406_412delTTGCACT	c.(406-414)TTGCACTCAfs	p.L136fs	CAMKV_uc011bcy.1_Frame_Shift_Del_p.L61fs|CAMKV_uc003cxv.1_Frame_Shift_Del_p.L136fs|CAMKV_uc003cxw.1_5'UTR|CAMKV_uc003cxx.1_5'UTR|CAMKV_uc003cxu.2_Frame_Shift_Del_p.L136fs|CAMKV_uc011bcz.1_Frame_Shift_Del_p.L99fs|CAMKV_uc011bda.1_Intron|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	136_138	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATCTTGAGTGAGTGCAAATAGGCCACG	0.609		NA											7	47	---	---	---	---	NA	NA	NA	NA
TNIK	23043	broad.mit.edu	37	3	170784400	170784409	+	Frame_Shift_Del	DEL	ACATCCTTAG	ACATCCTTAG	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:170784400_170784409delACATCCTTAG	uc003fhh.2	-	31	4160_4169	c.3815_3824delCTAAGGATGT	c.(3814-3825)ACTAAGGATGTGfs	p.T1272fs	TNIK_uc003fhi.2_Frame_Shift_Del_p.T1217fs|TNIK_uc003fhj.2_Frame_Shift_Del_p.T1243fs|TNIK_uc003fhk.2_Frame_Shift_Del_p.T1264fs|TNIK_uc003fhl.2_Frame_Shift_Del_p.T1188fs|TNIK_uc003fhm.2_Frame_Shift_Del_p.T1209fs|TNIK_uc003fhn.2_Frame_Shift_Del_p.T1235fs|TNIK_uc003fho.2_Frame_Shift_Del_p.T1180fs|TNIK_uc003fhg.2_Frame_Shift_Del_p.T450fs|TNIK_uc003fhp.2_Frame_Shift_Del_p.T204fs	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1272_1275	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTGGAGCACCACATCCTTAGTTATCCGGCC	0.448		NA											14	122	---	---	---	---	NA	NA	NA	NA
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:184039744_184039746delGAA	uc003fnp.2	+	10	1570_1572	c.1372_1374delGAA	c.(1372-1374)GAAdel	p.E465del	EIF4G1_uc003fno.1_In_Frame_Del_p.E406del|EIF4G1_uc010hxw.1_In_Frame_Del_p.E301del|EIF4G1_uc003fnt.2_In_Frame_Del_p.E176del|EIF4G1_uc003fnq.2_In_Frame_Del_p.E378del|EIF4G1_uc003fnr.2_In_Frame_Del_p.E301del|EIF4G1_uc010hxx.2_In_Frame_Del_p.E472del|EIF4G1_uc003fns.2_In_Frame_Del_p.E425del|EIF4G1_uc010hxy.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnv.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnu.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnw.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnx.2_In_Frame_Del_p.E269del|EIF4G1_uc003fny.3_In_Frame_Del_p.E269del	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.443		NA											7	132	---	---	---	---	NA	NA	NA	NA
FLNC	2318	broad.mit.edu	37	7	128490905	128490907	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:128490905_128490907delACA	uc003vnz.3	+	33	5656_5658	c.5447_5449delACA	c.(5446-5451)GACAAC>GAC	p.N1817del	FLNC_uc003voa.3_In_Frame_Del_p.N1784del	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1817	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AACATCACCGACAACAAGGACGG	0.596		NA											27	73	---	---	---	---	NA	NA	NA	NA
ARHGEF10	9639	broad.mit.edu	37	8	1905058	1905067	+	Frame_Shift_Del	DEL	GCACTTCCGA	GCACTTCCGA	-	rs145146038	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:1905058_1905067delGCACTTCCGA	uc003wpr.2	+	29	3842_3851	c.3664_3673delGCACTTCCGA	c.(3664-3675)GCACTTCCGAGTfs	p.A1222fs	ARHGEF10_uc003wps.2_Frame_Shift_Del_p.A1184fs|ARHGEF10_uc010lre.2_Frame_Shift_Del_p.A873fs	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1247_1250					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCAGAAGGACGCACTTCCGAGTGGAGGAGC	0.59		NA											15	70	---	---	---	---	NA	NA	NA	NA
