Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SPEN	23013	broad.mit.edu	37	1	16254617	16254617	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:16254617C>G	uc001axk.1	+	11	2086	c.1882C>G	c.(1882-1884)CAA>GAA	p.Q628E	SPEN_uc010obp.1_Missense_Mutation_p.Q587E	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	628	Arg-rich.|Tyr-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGACTATAACCAAGATCGTAC	0.403		NA											32	56					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103471421	103471421	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:103471421C>T	uc001dul.2	-	18	2136	c.1818G>A	c.(1816-1818)CCG>CCA	p.P606P	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.P618P|COL11A1_uc001dun.2_Silent_p.P567P|COL11A1_uc009weh.2_Silent_p.P490P	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	606	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGCAGACCCGGAAGTCCAT	0.303		NA											28	54					0	0	0	0
KCNA10	3744	broad.mit.edu	37	1	111060811	111060811	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:111060811C>T	uc001dzt.1	-	1	987	c.599G>A	c.(598-600)CGT>CAT	p.R200H		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	200			R -> H (in a colorectal cancer sample; somatic mutation).			voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity	p.R200H(1)		ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CCAGAACTGACGGTGGATGTC	0.547		NA											27	45					0	0	0	0
KCNA2	3737	broad.mit.edu	37	1	111147063	111147063	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:111147063C>T	uc001dzu.2	-	2	838	c.342G>A	c.(340-342)CGG>CGA	p.R114R	KCNA2_uc009wfv.1_Silent_p.R114R|KCNA2_uc009wfw.2_Silent_p.R114R	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	114						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GCTCATAAAACCGAATTTCTT	0.478		NA											14	34					0	0	0	0
RSBN1	54665	broad.mit.edu	37	1	114310877	114310877	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:114310877A>G	uc001edq.2	-	5	1829	c.1793T>C	c.(1792-1794)GTT>GCT	p.V598A	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	598						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAAACTCCAACAGCAGCCGT	0.438		NA											16	35					0	0	0	0
HIPK1	204851	broad.mit.edu	37	1	114506106	114506106	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:114506106G>T	uc001eem.2	+	10	2362	c.2201G>T	c.(2200-2202)GGC>GTC	p.G734V	HIPK1_uc001eel.2_Missense_Mutation_p.G734V|HIPK1_uc001een.2_Missense_Mutation_p.G734V|HIPK1_uc001eeo.2_Missense_Mutation_p.G360V|HIPK1_uc001eep.2_Missense_Mutation_p.G340V|HIPK1_uc001eeq.2_Missense_Mutation_p.G27V	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCGCAGCCGGCCGGCCGGCG	0.488		NA											22	42					1.11e-12	1.31e-12	1	0
ANKRD35	148741	broad.mit.edu	37	1	145562297	145562297	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:145562297C>T	uc001eob.1	+	10	2093	c.1985C>T	c.(1984-1986)GCG>GTG	p.A662V	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.A505V	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	662	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGCCAGAGGCGCAGGTCCAG	0.632		NA											19	41					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152285838	152285838	+	Silent	SNP	C	C	T	rs148161383	byFrequency	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:152285838C>T	uc001ezu.1	-	3	1560	c.1524G>A	c.(1522-1524)GCG>GCA	p.A508A	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	508	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCTTGGGACGCTGAATGCC	0.597		NA							Ichthyosis				143	278					0	0	0	0
NTRK1	4914	broad.mit.edu	37	1	156846199	156846199	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:156846199A>C	uc001fqh.1	+	14	1696	c.1640A>C	c.(1639-1641)AAG>ACG	p.K547T	NTRK1_uc001fqf.1_Missense_Mutation_p.K511T|NTRK1_uc009wsi.1_Missense_Mutation_p.K246T|NTRK1_uc001fqi.1_Missense_Mutation_p.K541T|NTRK1_uc009wsk.1_Missense_Mutation_p.K544T	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	547	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CAGGCACTGAAGGAGGCGTCC	0.657		NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			6	27					0	0	0	0
FASLG	356	broad.mit.edu	37	1	172634881	172634881	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:172634881G>T	uc001gis.2	+	4	728	c.571G>T	c.(571-573)GTA>TTA	p.V191L	FASLG_uc001git.2_3'UTR	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	191	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						GCTGTACTTTGTATATTCCAA	0.468		NA											25	61					1.43e-11	1.67e-11	1	0
RASAL2	9462	broad.mit.edu	37	1	178423671	178423671	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:178423671C>G	uc001glr.2	+	10	1780	c.1655C>G	c.(1654-1656)TCT>TGT	p.S552C	RASAL2_uc001glq.2_Missense_Mutation_p.S700C|RASAL2_uc009wxc.2_Missense_Mutation_p.S66C	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	552					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TTGGAGATCTCTAATCCAGAC	0.423		NA											37	77					0	0	0	0
C1orf27	54953	broad.mit.edu	37	1	186367550	186367550	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:186367550C>A	uc001grw.2	+	10	1122	c.886C>A	c.(886-888)CCC>ACC	p.P296T	C1orf27_uc010poq.1_Missense_Mutation_p.P273T|C1orf27_uc010por.1_Missense_Mutation_p.P264T|OCLM_uc001gry.2_5'Flank	NM_017847	NP_060317	Q5SWX8	ODR4_HUMAN	odorant response abnormal 4 isoform 1	296						integral to membrane	oxidoreductase activity|zinc ion binding			ovary(1)	1						CAGCAGTAAACCCAAAGTTAA	0.378		NA											28	30					7.42e-09	8.35e-09	1	0
KCNT2	343450	broad.mit.edu	37	1	196309633	196309633	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:196309633G>A	uc001gtd.1	-	16	1681	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.R491*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.R541*|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Nonsense_Mutation_p.R541*|KCNT2_uc001gth.1_Nonsense_Mutation_p.R62*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	541	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATAATGTATCGAGGACCTGGA	0.323		NA											14	34					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228434319	228434319	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:228434319C>A	uc009xez.1	+	13	3892	c.3848C>A	c.(3847-3849)GCC>GAC	p.A1283D	OBSCN_uc001hsn.2_Missense_Mutation_p.A1283D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1283	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGTGAGGTGGCCCAGGCCCAG	0.612		NA											33	45					2.85e-18	3.49e-18	1	0
C1orf198	84886	broad.mit.edu	37	1	231004121	231004121	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:231004121G>T	uc001hub.2	-	1	182	c.138C>A	c.(136-138)GAC>GAA	p.D46E	C1orf198_uc001huc.1_Intron|C1orf198_uc001hud.1_Missense_Mutation_p.D8E	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	46											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TCTTCTCCTTGTCCTGCATGA	0.612		NA											15	16					1.15e-07	1.27e-07	1	0
CTNNA3	29119	broad.mit.edu	37	10	68139106	68139106	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:68139106G>T	uc009xpn.1	-	12	1659	c.1536C>A	c.(1534-1536)AGC>AGA	p.S512R	CTNNA3_uc001jmw.2_Missense_Mutation_p.S512R	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	512					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CCAAGATATGGCTTTCTGTAA	0.378		NA											18	40					2.35e-11	2.74e-11	1	0
CTBP2	1488	broad.mit.edu	37	10	126682531	126682531	+	Silent	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:126682531C>A	uc009yak.2	-	8	1091	c.804G>T	c.(802-804)GTG>GTT	p.V268V	CTBP2_uc009yal.2_Silent_p.V268V|CTBP2_uc001lif.3_Silent_p.V268V|CTBP2_uc001lih.3_Silent_p.V268V|CTBP2_uc001lid.3_Silent_p.V336V|CTBP2_uc001lie.3_Silent_p.V808V	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	268					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GGGCTGCGTTCACAAGGAATG	0.557		NA											40	66					3.43e-17	4.16e-17	1	0
OSBPL5	114879	broad.mit.edu	37	11	3121473	3121473	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:3121473C>T	uc001lxk.2	-	14	1694	c.1536G>A	c.(1534-1536)TCG>TCA	p.S512S	OSBPL5_uc010qxq.1_Silent_p.S423S|OSBPL5_uc009ydw.2_Silent_p.S444S|OSBPL5_uc001lxl.2_Silent_p.S444S|OSBPL5_uc009ydx.2_Silent_p.S536S	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	512					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCAGCAGCGCCGACAGCGAGT	0.607		NA											11	13					0	0	0	0
OR5D14	219436	broad.mit.edu	37	11	55563815	55563815	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:55563815T>A	uc010rim.1	+	1	784	c.784T>A	c.(784-786)TGT>AGT	p.C262S		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTTCCTTTACTGTGTACCCAA	0.488		NA											21	30					0	0	0	0
MARK2	2011	broad.mit.edu	37	11	63666242	63666242	+	Silent	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:63666242A>G	uc001nxw.2	+	6	990	c.411A>G	c.(409-411)GTA>GTG	p.V137V	MARK2_uc001nxx.2_Silent_p.V137V|MARK2_uc001nxy.2_Silent_p.V137V|MARK2_uc001nxv.3_Silent_p.V137V|MARK2_uc001nxz.3_Silent_p.V104V|MARK2_uc009yoy.2_Silent_p.V104V	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	137	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CAGGAGAGGTATTTGATTACC	0.552		NA											17	52					0	0	0	0
CPT1A	1374	broad.mit.edu	37	11	68552321	68552321	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:68552321G>A	uc001oog.3	-	10	1295	c.1125C>T	c.(1123-1125)CCC>CCT	p.P375P	CPT1A_uc001oof.3_Silent_p.P375P|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	375	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TGGCCTCCCCGGGCTGAGGCT	0.642		NA											28	30					0	0	0	0
CAPN5	726	broad.mit.edu	37	11	76796018	76796018	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:76796018A>C	uc001oxx.2	+	2	271	c.86A>C	c.(85-87)GAC>GCC	p.D29A	CAPN5_uc009yup.2_Missense_Mutation_p.D29A|CAPN5_uc009yuq.2_Missense_Mutation_p.D65A|CAPN5_uc001oxy.2_Missense_Mutation_p.D69A	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	29	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CTCTTCGAGGACCCCCTCTTC	0.642		NA											5	28					0	0	0	0
GRIA4	2893	broad.mit.edu	37	11	105804580	105804580	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:105804580G>T	uc001pix.2	+	14	2625	c.2179G>T	c.(2179-2181)GAG>TAG	p.E727*	GRIA4_uc001piw.2_Nonsense_Mutation_p.E727*|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	727	Extracellular (Potential).	Glutamate (By similarity).			glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTTTCTCCTGGAGTCCACTAT	0.488		NA											20	31					4.63e-17	5.59e-17	1	0
ADAMTS8	11095	broad.mit.edu	37	11	130275888	130275888	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:130275888G>A	uc001qgg.3	-	9	2593	c.2235C>T	c.(2233-2235)AAC>AAT	p.N745N	ADAMTS8_uc001qgf.2_Silent_p.N226N	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	745	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CCAGGTTGCCGTTGAGCAGGT	0.597		NA											17	70					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49435983	49435983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:49435983G>A	uc001rta.3	-	28	5998	c.5998C>T	c.(5998-6000)CAG>TAG	p.Q2000*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2000					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGACTCCGCTGGTTATAGGAG	0.607		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			7	7					0	0	0	0
FMNL3	91010	broad.mit.edu	37	12	50044492	50044492	+	Missense_Mutation	SNP	C	C	A	rs149056505	by1000genomes	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:50044492C>A	uc001ruv.1	-	17	2201	c.1967G>T	c.(1966-1968)CGC>CTC	p.R656L	FMNL3_uc001ruw.1_Missense_Mutation_p.R605L|FMNL3_uc001rut.1_Missense_Mutation_p.R222L|FMNL3_uc001ruu.1_Missense_Mutation_p.R506L	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	656	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CTCAGCCGAGCGGCCAGCCTT	0.582		NA											23	32					4.72e-08	5.27e-08	1	0
DAZAP2	9802	broad.mit.edu	37	12	51636287	51636287	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:51636287C>T	uc010snd.1	+	4	659	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	DAZAP2_uc001ryb.2_3'UTR|DAZAP2_uc010snc.1_3'UTR|DAZAP2_uc010sne.1_3'UTR|DAZAP2_uc010snf.1_Intron	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	Error:Variant_position_missing_in_Q15038_after_alignment							WW domain binding				0						CACATACCTTCAGCACTTCTC	0.483		NA											19	46					0	0	0	0
NR4A1	3164	broad.mit.edu	37	12	52451148	52451148	+	Silent	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:52451148C>A	uc001rzs.2	+	7	1688	c.1374C>A	c.(1372-1374)GGC>GGA	p.G458G	NR4A1_uc010sno.1_Silent_p.G471G|NR4A1_uc001rzt.2_Silent_p.G458G|NR4A1_uc009zmc.2_Missense_Mutation_p.A72E	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	458	Ligand-binding (Potential).				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CTAAGCCAGGCGAGGGCAAGC	0.607		NA											17	33					3.41e-10	3.92e-10	1	0
PA2G4	5036	broad.mit.edu	37	12	56506656	56506656	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:56506656A>G	uc001sjm.2	+	13	1588	c.1169A>G	c.(1168-1170)AAT>AGT	p.N390S	PA2G4_uc009zol.2_Missense_Mutation_p.N372S|PA2G4_uc009zom.2_3'UTR	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	390	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			TTAGAAGAAAATGAAGCTGGG	0.517		NA											27	65					0	0	0	0
RAB21	23011	broad.mit.edu	37	12	72176380	72176380	+	Nonsense_Mutation	SNP	T	T	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:72176380T>G	uc001swt.2	+	6	729	c.477T>G	c.(475-477)TAT>TAG	p.Y159*		NM_014999	NP_055814	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	159					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0						CAAAACATTATCATACTTCAG	0.303		NA											10	22					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81545669	81545669	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:81545669C>A	uc001szl.1	+	6	1059	c.968C>A	c.(967-969)TCA>TAA	p.S323*	ACSS3_uc001szm.1_Nonsense_Mutation_p.S322*|ACSS3_uc001szn.1_Nonsense_Mutation_p.S5*	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	323						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTACACTGGTCAATGTCTTCC	0.343		NA											19	45					5.26e-13	6.25e-13	1	0
CMKLR1	1240	broad.mit.edu	37	12	108686279	108686279	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:108686279C>T	uc009zuw.2	-	3	652	c.461G>A	c.(460-462)CGC>CAC	p.R154H	CMKLR1_uc001tmw.2_Missense_Mutation_p.R154H|CMKLR1_uc001tmv.2_Missense_Mutation_p.R152H|CMKLR1_uc009zuv.2_Missense_Mutation_p.R154H	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	154	Cytoplasmic (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GTAAGCCAGGCGAACGCTGCG	0.562		NA											10	38					0	0	0	0
TPTE2	93492	broad.mit.edu	37	13	20025355	20025355	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:20025355C>T	uc001umd.2	-	12	963	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R140Q|TPTE2_uc001ume.2_Missense_Mutation_p.R174Q|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	251	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATCTAGAAACCGCACAACTTC	0.338		NA											20	41					0	0	0	0
PCDH9	5101	broad.mit.edu	37	13	67802486	67802486	+	Silent	SNP	A	A	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:67802486A>T	uc001vik.2	-	2	779	c.87T>A	c.(85-87)ACT>ACA	p.T29T	PCDH9_uc001vil.2_Silent_p.T29T|PCDH9_uc010thl.1_Silent_p.T29T|PCDH9_uc001vin.3_Silent_p.T29T	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	29	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CCTCTCTAATAGTGTAAATAA	0.433		NA											27	42					0	0	0	0
TPP2	7174	broad.mit.edu	37	13	103271177	103271177	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:103271177C>T	uc001vpi.3	+	5	704	c.601C>T	c.(601-603)CAT>TAT	p.H201Y		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	201					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTGGTATGGCATGATGGCGA	0.368		NA											29	85					0	0	0	0
SEC23A	10484	broad.mit.edu	37	14	39509955	39509955	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:39509955G>A	uc001wup.1	-	18	2346	c.2123C>T	c.(2122-2124)ACT>ATT	p.T708I	SEC23A_uc010tqa.1_Missense_Mutation_p.T594I|SEC23A_uc010tqb.1_Missense_Mutation_p.T679I	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	708					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TCCATGTTCAGTGTCAATGTA	0.428		NA											83	84					0	0	0	0
SOS2	6655	broad.mit.edu	37	14	50597308	50597308	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:50597308G>T	uc001wxs.3	-	20	3346	c.3248C>A	c.(3247-3249)CCA>CAA	p.P1083Q	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.P1050Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1083					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TGGAGAGGTTGGTGCTGACAC	0.423		NA											65	83					1.32e-49	1.64e-49	1	0
ZC3H14	79882	broad.mit.edu	37	14	89063145	89063145	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:89063145G>A	uc001xww.2	+	10	1572	c.1347G>A	c.(1345-1347)ATG>ATA	p.M449I	ZC3H14_uc010twd.1_Missense_Mutation_p.M449I|ZC3H14_uc010twe.1_Missense_Mutation_p.M449I|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Missense_Mutation_p.M294I|ZC3H14_uc001xwy.2_Missense_Mutation_p.M415I|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Intron|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Missense_Mutation_p.M151I	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	449						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTCTGCAGATGAGTCAAGGTT	0.383		NA											23	56					0	0	0	0
TTC7B	145567	broad.mit.edu	37	14	91007854	91007854	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:91007854G>T	uc001xyp.2	-	20	2512	c.2390C>A	c.(2389-2391)GCC>GAC	p.A797D	TTC7B_uc001xyo.2_Missense_Mutation_p.A241D|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	797	TPR 10.						binding			ovary(2)	2		Melanoma(154;0.222)				GACCTCGTGGGCTGTCGAGTT	0.647		NA											12	42					1.58e-08	1.78e-08	1	0
PLA2G4E	123745	broad.mit.edu	37	15	42292147	42292147	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr15:42292147G>A	uc001zow.1	-	8	817	c.817C>T	c.(817-819)CTT>TTT	p.L273F	PLA2G4E_uc010udc.1_5'Flank|PLA2G4E_uc001zov.1_5'Flank	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	295					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		CCATCGGAAAGGCAGTCGAGG	0.642		NA											4	6					0	0	0	0
STRA6	64220	broad.mit.edu	37	15	74490148	74490148	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr15:74490148G>A	uc002axk.2	-	3	307	c.125C>T	c.(124-126)TCC>TTC	p.S42F	STRA6_uc002axi.2_5'Flank|STRA6_uc010ulh.1_Missense_Mutation_p.S80F|STRA6_uc002axj.2_Missense_Mutation_p.S81F|STRA6_uc010bji.2_Missense_Mutation_p.S42F|STRA6_uc002axl.2_5'UTR|STRA6_uc002axm.2_Missense_Mutation_p.S42F|STRA6_uc002axn.2_Missense_Mutation_p.S42F|STRA6_uc010uli.1_Missense_Mutation_p.S79F|STRA6_uc010bjj.1_RNA|STRA6_uc010bjk.2_Missense_Mutation_p.S42F	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	42	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						GGTGTGGCAGGAGGGCACTTC	0.622		NA											3	25					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3788645	3788646	+	Missense_Mutation	DNP	TA	TA	AC			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:3788645_3788646TA>AC	uc002cvv.2	-	26	4512_4513	c.4308_4309TA>GT	c.(4306-4311)AGTATT>AGGTTT	p.1436_1437SI>RF	CREBBP_uc002cvw.2_Missense_Mutation_p.1398_1399SI>RF	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1436_1437	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGAAATGAATACTATCCAGAT	0.416		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				3	19					0	0	0	0
ERCC4	2072	broad.mit.edu	37	16	14029437	14029437	+	Missense_Mutation	SNP	C	C	T	rs139197943		TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:14029437C>T	uc002dce.2	+	8	1657	c.1648C>T	c.(1648-1650)CCC>TCC	p.P550S	ERCC4_uc010uyz.1_Missense_Mutation_p.P100S	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	550					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CCTGAAAGAACCCCTCACTAT	0.463		NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				22	53					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570579	20570579	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:20570579A>G	uc002dhj.3	-	4	578	c.368T>C	c.(367-369)ATC>ACC	p.I123T	ACSM2B_uc002dhk.3_Missense_Mutation_p.I123T|ACSM2B_uc010bwf.1_Missense_Mutation_p.I123T	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	123					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GCAGCCCAGGATCACCAGCCA	0.577		NA											8	17					0	0	0	0
CLN3	1201	broad.mit.edu	37	16	28497943	28497943	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:28497943G>A	uc002dpo.2	-	7	812	c.489C>T	c.(487-489)GGC>GGT	p.G163G	uc010vct.1_Intron|CLN3_uc002dpl.2_Silent_p.G85G|CLN3_uc010vcu.1_Silent_p.G63G|CLN3_uc002dpn.2_Intron|CLN3_uc002dpm.2_Silent_p.G109G|CLN3_uc010vcv.1_Silent_p.G139G|CLN3_uc010byd.2_Silent_p.G163G|CLN3_uc002dpp.2_Silent_p.G163G|CLN3_uc002dpt.1_Silent_p.G63G|CLN3_uc002dpq.1_Silent_p.G163G|CLN3_uc010bye.1_Silent_p.G163G|CLN3_uc002dpr.1_Intron|CLN3_uc010byf.1_Intron|CLN3_uc002dps.1_Intron|CLN3_uc002dpu.1_Silent_p.G109G|CLN3_uc002dpw.1_Intron|CLN3_uc010vcw.1_Silent_p.G109G|CLN3_uc002dqa.2_Silent_p.G214G|CLN3_uc010vcx.1_Silent_p.G63G|CLN3_uc002dpx.1_Intron|CLN3_uc002dpy.1_Intron|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	163					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						CCTCCCCAAGGCCTGATGAGA	0.607		NA											3	9					0	0	0	0
CENPBD1	92806	broad.mit.edu	37	16	90038291	90038291	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:90038291T>G	uc002fpr.2	-	1	652	c.40A>C	c.(40-42)AGT>CGT	p.S14R	AFG3L1_uc002fps.1_5'Flank|AFG3L1_uc002fpt.1_5'Flank|AFG3L1_uc002fpu.1_5'Flank|AFG3L1_uc002fpv.1_5'Flank|AFG3L1_uc002fpw.1_5'Flank|AFG3L1_uc002fpx.1_5'Flank	NM_145039	NP_659476	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	14	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CTTTTGGCACTAGGGATGACA	0.502		NA											9	23					0	0	0	0
ACADVL	37	broad.mit.edu	37	17	7124963	7124963	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:7124963A>G	uc002gev.2	+	7	735	c.584A>G	c.(583-585)AAG>AGG	p.K195R	DLG4_uc002get.3_5'Flank|DLG4_uc010vto.1_5'Flank|ACADVL_uc010vtp.1_Missense_Mutation_p.K205R|ACADVL_uc010vtq.1_Missense_Mutation_p.K241R|ACADVL_uc002gew.2_Missense_Mutation_p.K173R|ACADVL_uc002gex.2_Missense_Mutation_p.K119R	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	195	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TTTGGCACAAAGGCCCAGAAA	0.577		NA											27	57					0	0	0	0
RAB5C	5878	broad.mit.edu	37	17	40282496	40282496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:40282496G>A	uc002hyz.2	-	3	342	c.25C>T	c.(25-27)CGA>TGA	p.R9*	RAB5C_uc002hza.2_Nonsense_Mutation_p.R9*|RAB5C_uc010cxx.2_Nonsense_Mutation_p.R42*|RAB5C_uc010cxy.2_Intron	NM_201434	NP_958842	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family isoform a	9					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|skin(1)	2		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CCATTGGGTCGTGCTGCGCCT	0.602		NA											11	19					0	0	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944756	74944756	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:74944756A>T	uc002jti.2	+	16	2345	c.2242A>T	c.(2242-2244)ATG>TTG	p.M748L	MGAT5B_uc002jth.2_Missense_Mutation_p.M737L|MGAT5B_uc002jtj.2_Missense_Mutation_p.M144L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	739	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CGAGTCGGAGATGAACCACCT	0.652		NA											4	9					0	0	0	0
CDH2	1000	broad.mit.edu	37	18	25593761	25593761	+	Silent	SNP	G	G	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr18:25593761G>C	uc002kwg.2	-	3	744	c.285C>G	c.(283-285)CTC>CTG	p.L95L	CDH2_uc010xbn.1_Silent_p.L64L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	95					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GCTCAGAAGAGAGTGGAAAGC	0.448		NA											24	21					0	0	0	0
CCDC159	126075	broad.mit.edu	37	19	11464486	11464488	+	Missense_Mutation	TNP	GCA	GCA	TAT			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:11464486_11464488GCA>TAT	uc010xlw.1	+	10	1036_1038	c.957_959GCA>TAT	c.(955-960)CTGCAG>CTTATG	p.Q320M	CCDC159_uc010xlt.1_Missense_Mutation_p.Q237M|LPPR2_uc002mre.1_5'Flank|LPPR2_uc002mrf.1_5'Flank	NM_001080503	NP_001073972	P0C7I6	CC159_HUMAN	coiled-coil domain-containing-like	352										ovary(1)	1						TGCACGTGCTGCAGAACTCCATA	0.601		NA											4	7					0	0	0	0
ZNF333	84449	broad.mit.edu	37	19	14805946	14805946	+	Splice_Site	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:14805946G>A	uc002mzn.2	+	3	261	c.127_splice	c.e3+1	p.G43_splice	ZNF333_uc010dzq.2_Splice_Site_p.G43_splice|ZNF333_uc002mzk.3_Splice_Site|ZNF333_uc002mzl.3_Splice_Site_p.G43_splice|ZNF333_uc002mzm.2_Splice_Site_p.G43_splice|ZNF333_uc010dzr.1_Splice_Site	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCCTCCAGGGGTAAGGCTGGC	0.582		NA											13	26					0	0	0	0
JAK3	3718	broad.mit.edu	37	19	17941381	17941381	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:17941381G>A	uc002nhn.3	-	22	3127	c.3027C>T	c.(3025-3027)GAC>GAT	p.D1009D	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.D1009D	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	1009	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						AGCTCCAGACGTCTGACTGGC	0.597		2	Mis		acute megakaryocytic leukemia|								18	24					0	0	0	0
ZNF546	339327	broad.mit.edu	37	19	40520277	40520277	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:40520277G>A	uc002oms.2	+	7	1356	c.1100G>A	c.(1099-1101)AGG>AAG	p.R367K	ZNF546_uc002omt.2_Missense_Mutation_p.R341K	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	367	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGACCTTTAGGGTACAACGA	0.388		NA											18	35					0	0	0	0
PSG8	440533	broad.mit.edu	37	19	43268311	43268311	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:43268311T>C	uc002ouo.2	-	2	285	c.187A>G	c.(187-189)ACT>GCT	p.T63A	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.T63A|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.T63A|PSG8_uc002oum.3_Missense_Mutation_p.T63A|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T63A	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	63	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				ATGTAGCCAGTAAGATTCTGG	0.458		NA											90	197					0	0	0	0
AP2A1	160	broad.mit.edu	37	19	50302996	50302996	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:50302996G>A	uc002ppn.2	+	10	1456	c.1245G>A	c.(1243-1245)ACG>ACA	p.T415T	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.T415T|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	415					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ACCTGGAGACGGCAGACTACG	0.438		NA											9	18					0	0	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914599	51914599	+	Silent	SNP	T	T	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:51914599T>C	uc002pwo.2	-	11	2464	c.1848A>G	c.(1846-1848)ACA>ACG	p.T616T	SIGLEC10_uc002pwp.2_Silent_p.T558T|SIGLEC10_uc002pwq.2_Silent_p.T463T|SIGLEC10_uc002pwr.2_Silent_p.T521T|SIGLEC10_uc010ycy.1_Silent_p.T431T|SIGLEC10_uc010ycz.1_Silent_p.T473T|SIGLEC10_uc010eow.2_Silent_p.T333T	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	616	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GACTGTTTGGTGTGGCTTTCT	0.398		NA											27	52					0	0	0	0
KIR3DL3	115653	broad.mit.edu	37	19	55239225	55239225	+	Silent	SNP	T	T	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:55239225T>C	uc002qgu.1	+	4	522	c.504T>C	c.(502-504)GTT>GTC	p.V168V	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	168	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		TGCGCCTCGTTGGACAGCTCC	0.557		NA											4	71					0	0	0	0
ZNF671	79891	broad.mit.edu	37	19	58232346	58232346	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:58232346G>T	uc002qpz.3	-	4	1207	c.1108C>A	c.(1108-1110)CAG>AAG	p.Q370K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.Q293K|ZNF671_uc010yhf.1_Missense_Mutation_p.Q272K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	370	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTGCCACACTGATAGAGTCTT	0.473		NA											18	34					5.01e-05	5.43e-05	1	0
CCDC85A	114800	broad.mit.edu	37	2	56420052	56420052	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:56420052G>A	uc002rzn.2	+	2	1219	c.717G>A	c.(715-717)AAG>AAA	p.K239K		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	239	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCTGCAGAAGCCCCGGAGCG	0.672		NA											16	18					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97784187	97784187	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:97784187A>G	uc010yva.1	+	3	663	c.419A>G	c.(418-420)TAT>TGT	p.Y140C	ANKRD36_uc002sxn.2_Missense_Mutation_p.Y140C|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.Y140C|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	140	ANK 4.										0						TACGCTGTGTATAATGAAGAT	0.398		NA											21	11					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167055277	167055277	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:167055277A>G	uc010fpl.2	-	27	6180	c.5839T>C	c.(5839-5841)TAT>CAT	p.Y1947H	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1958						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACACTATCATATGAAGGTGGA	0.358		NA											3	17					0	0	0	0
FARSB	10056	broad.mit.edu	37	2	223497951	223497951	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:223497951C>A	uc002vne.1	-	7	717	c.682G>T	c.(682-684)GGT>TGT	p.G228C	FARSB_uc010zlq.1_Missense_Mutation_p.G248C|FARSB_uc002vnf.1_Missense_Mutation_p.G129C	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	228					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	AGGACGACACCATTGCTATCA	0.333		NA											32	83					9.63e-15	1.15e-14	1	0
ARMC9	80210	broad.mit.edu	37	2	232209757	232209757	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:232209757T>A	uc002vrq.3	+	21	2061	c.1949T>A	c.(1948-1950)CTG>CAG	p.L650Q	ARMC9_uc002vrp.3_Missense_Mutation_p.L650Q|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	650							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GATGAGCCCCTGCAAAGGCCC	0.547		NA											33	52					0	0	0	0
CSNK2A1	1457	broad.mit.edu	37	20	468128	468128	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:468128G>A	uc002wdw.1	-	12	1309	c.916C>T	c.(916-918)CGA>TGA	p.R306*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.R306*|CSNK2A1_uc002wdy.1_Nonsense_Mutation_p.R170*	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	306	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TGGTCATATCGCAGCAGTTTG	0.527		NA											39	68					0	0	0	0
ISM1	140862	broad.mit.edu	37	20	13279750	13279750	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:13279750C>T	uc010gce.1	+	6	1045	c.1039C>T	c.(1039-1041)CGC>TGC	p.R347C	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	347	AMOP.					extracellular region					0						CAAGGACTTCCGCTGGAAGGA	0.627		NA											4	26					0	0	0	0
VSX1	30813	broad.mit.edu	37	20	25057052	25057052	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:25057052C>A	uc002wuf.2	-	5	978	c.943G>T	c.(943-945)GTG>TTG	p.V315L	VSX1_uc002wue.2_Intron|VSX1_uc010gdd.1_Intron|VSX1_uc010gde.1_Intron|VSX1_uc010gdf.1_Intron	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	315					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAGGGCTCACTTTATCTGAG	0.547		NA											37	53					5.73e-09	6.52e-09	1	0
PHF20	51230	broad.mit.edu	37	20	34389470	34389470	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:34389470G>T	uc002xek.1	+	2	137	c.26G>T	c.(25-27)CGA>CTA	p.R9L	PHF20_uc002xei.1_Missense_Mutation_p.R9L|PHF20_uc010gfo.1_Missense_Mutation_p.R9L|PHF20_uc002xej.1_5'UTR|PHF20_uc002xeh.2_RNA	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCTAACAGACGAGGAATCAGC	0.408		NA											15	37					1.57e-10	1.82e-10	1	0
PTPRT	11122	broad.mit.edu	37	20	40730876	40730876	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:40730876C>A	uc002xkg.2	-	26	3786	c.3602G>T	c.(3601-3603)CGG>CTG	p.R1201L	PTPRT_uc010ggj.2_Missense_Mutation_p.R1220L|PTPRT_uc010ggi.2_Missense_Mutation_p.R404L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1201	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCATGGTTCCGGGGCAGGAG	0.557		NA											20	29					2.46e-09	2.81e-09	1	0
SFRS6	6431	broad.mit.edu	37	20	42088474	42088474	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:42088474G>C	uc010zwg.1	+	3	490	c.320G>C	c.(319-321)CGT>CCT	p.R107P	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.R107P	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	107					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCACCTGTTCGTACAGAATAC	0.393		NA											38	58					0	0	0	0
DGCR14	8220	broad.mit.edu	37	22	19130247	19130247	+	Missense_Mutation	SNP	G	G	A	rs111488352	byFrequency	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:19130247G>A	uc002zou.2	-	2	333	c.296C>T	c.(295-297)CCG>CTG	p.P99L	DGCR14_uc002zot.2_Missense_Mutation_p.P20L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	99					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					ACAGGGTGGCGGGGGCTCCCG	0.582		NA											5	112					0	0	0	0
MN1	4330	broad.mit.edu	37	22	28193502	28193502	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:28193502C>G	uc003adj.2	-	1	3985	c.3030G>C	c.(3028-3030)TGG>TGC	p.W1010C		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1010							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CCCCCTTCCCCCAGGATGGCG	0.692		NA	T	ETV6	AML|meningioma								21	42					0	0	0	0
OSBP2	23762	broad.mit.edu	37	22	31286872	31286872	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:31286872G>A	uc003aiy.1	+	8	1885	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	OSBP2_uc011ala.1_Missense_Mutation_p.R428H|OSBP2_uc010gwc.1_Missense_Mutation_p.R421H|OSBP2_uc011alb.1_Missense_Mutation_p.R545H|OSBP2_uc003aiz.1_Missense_Mutation_p.R593H|OSBP2_uc003aja.1_Missense_Mutation_p.R227H|OSBP2_uc011alc.1_Missense_Mutation_p.R336H|OSBP2_uc003ajb.2_Missense_Mutation_p.R139H|OSBP2_uc011ald.1_Missense_Mutation_p.R138H|OSBP2_uc010gwd.1_Missense_Mutation_p.R139H	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	594					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						ACAGTGCACCGCATCGCCAAG	0.642		NA									OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	36					0	0	0	0
CSF2RB	1439	broad.mit.edu	37	22	37322077	37322077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:37322077G>A	uc003aqa.3	+	4	466	c.249G>A	c.(247-249)TGG>TGA	p.W83*	CSF2RB_uc003aqc.3_Nonsense_Mutation_p.W83*	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	83	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	ACATGCCCTGGTCAGCCTGCC	0.547		NA											11	36					0	0	0	0
CYTH4	27128	broad.mit.edu	37	22	37695300	37695300	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:37695300C>T	uc003arf.2	+	6	503	c.387C>T	c.(385-387)TTC>TTT	p.F129F	CYTH4_uc003are.2_Silent_p.F129F|CYTH4_uc011amw.1_Silent_p.F72F|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	129	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCAGGCCTTCGTGGACTGCC	0.657		NA											10	22					0	0	0	0
PPPDE2	27351	broad.mit.edu	37	22	42000099	42000099	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:42000099G>C	uc003ban.1	-	4	312	c.239C>G	c.(238-240)ACA>AGA	p.T80R	PPPDE2_uc011apb.1_RNA	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	80	PPPDE peptidase.										0						GATTTCTTCTGTGACTTCTGT	0.527		NA											24	79					0	0	0	0
PLXNB1	5364	broad.mit.edu	37	3	48451945	48451945	+	Silent	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:48451945C>A	uc003csw.2	-	30	5709	c.5439G>T	c.(5437-5439)GGG>GGT	p.G1813G	PLXNB1_uc003cst.2_Silent_p.G263G|PLXNB1_uc003csu.2_Silent_p.G1630G|PLXNB1_uc003csx.2_Silent_p.G1813G	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1813	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAATGAGGTGCCCGGCCACCC	0.597		NA											18	21					4.97e-08	5.51e-08	1	0
SHISA5	51246	broad.mit.edu	37	3	48510918	48510918	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:48510918G>T	uc003ctp.1	-	5	619	c.485C>A	c.(484-486)CCT>CAT	p.P162H	SHISA5_uc003ctn.1_Silent_p.A30A|SHISA5_uc003ctm.1_Missense_Mutation_p.P59H|SHISA5_uc011bbk.1_Silent_p.A70A|SHISA5_uc003cto.1_Missense_Mutation_p.P131H|SHISA5_uc003ctq.1_Missense_Mutation_p.P155H|SHISA5_uc003ctr.1_Missense_Mutation_p.P131H|SHISA5_uc003cts.1_Missense_Mutation_p.P131H|SHISA5_uc003ctt.2_Missense_Mutation_p.P59H|SHISA5_uc003ctu.1_RNA|SHISA5_uc011bbl.1_Missense_Mutation_p.P60H	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	162	Cytoplasmic (Potential).|Pro-rich.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						CACACTTGGAGGCTGAGGATA	0.607		NA											13	20					2.27e-07	2.49e-07	1	0
RNF123	63891	broad.mit.edu	37	3	49742142	49742142	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:49742142A>G	uc003cxh.2	+	22	1998	c.1912A>G	c.(1912-1914)ATG>GTG	p.M638V	RNF123_uc010hky.1_Missense_Mutation_p.M300V|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	638						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GTCAACCGCCATGGATGACCT	0.587		NA											4	6					0	0	0	0
EPHB1	2047	broad.mit.edu	37	3	134884901	134884901	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:134884901C>T	uc003eqt.2	+	8	1897	c.1677C>T	c.(1675-1677)ATC>ATT	p.I559I	EPHB1_uc003equ.2_Silent_p.I120I	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	559	Helical; (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGGTGGCCATCTCTATCGTCT	0.587		NA											32	106					0	0	0	0
ZIC1	7545	broad.mit.edu	37	3	147128258	147128258	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:147128258T>C	uc003ewe.2	+	1	1078	c.359T>C	c.(358-360)CTC>CCC	p.L120P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	120					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGCACAGCCTCTTTGCTGCA	0.706		NA											16	40					0	0	0	0
ATP11B	23200	broad.mit.edu	37	3	182597414	182597414	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:182597414A>G	uc003flb.2	+	20	2640	c.2383A>G	c.(2383-2385)ATG>GTG	p.M795V	ATP11B_uc003flc.2_Missense_Mutation_p.M379V|ATP11B_uc011bqm.1_Missense_Mutation_p.M99V|ATP11B_uc010hxf.1_5'UTR	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	795	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATGCTGTCGTATGGCTCCACT	0.353		NA											22	67					0	0	0	0
CCDC50	152137	broad.mit.edu	37	3	191098615	191098615	+	Splice_Site	SNP	A	A	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:191098615A>C	uc003fsw.2	+	8	1200	c.610_splice	c.e8-2	p.E204_splice	CCDC50_uc003fsv.2_Splice_Site_p.E380_splice	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform							cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		TATTTTGTTTAGGAAATCGCT	0.368		NA											11	42					0	0	0	0
GPR125	166647	broad.mit.edu	37	4	22439976	22439976	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:22439976G>A	uc003gqm.1	-	8	1253	c.988C>T	c.(988-990)CGT>TGT	p.R330C	GPR125_uc010ieo.1_Missense_Mutation_p.R204C|GPR125_uc003gqn.1_Missense_Mutation_p.R104C|GPR125_uc003gqo.2_Missense_Mutation_p.R330C	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	330	Extracellular (Potential).|Ig-like.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				TTATTCCCACGTTTGGTCTGG	0.423		NA											29	46					0	0	0	0
SHROOM3	57619	broad.mit.edu	37	4	77676119	77676119	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:77676119C>T	uc011cbx.1	+	7	5436	c.4483C>T	c.(4483-4485)CGG>TGG	p.R1495W	SHROOM3_uc003hkg.2_Missense_Mutation_p.R1273W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1495					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GTCTGTCCTGCGGGACTCCCC	0.577		NA											20	55					0	0	0	0
CENPE	1062	broad.mit.edu	37	4	104070291	104070291	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:104070291C>G	uc003hxb.1	-	27	3761	c.3671G>C	c.(3670-3672)AGA>ACA	p.R1224T	CENPE_uc003hxc.1_Missense_Mutation_p.R1199T	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1224	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTCAATTTCTCTTATATATCC	0.338		NA											21	39					0	0	0	0
SEC24B	10427	broad.mit.edu	37	4	110442694	110442694	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:110442694G>T	uc003hzk.2	+	14	2475	c.2420G>T	c.(2419-2421)CGT>CTT	p.R807L	SEC24B_uc003hzl.2_Missense_Mutation_p.R772L|SEC24B_uc011cfp.1_Missense_Mutation_p.R837L|SEC24B_uc011cfq.1_Missense_Mutation_p.R806L|SEC24B_uc011cfr.1_Missense_Mutation_p.R771L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	807					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ACAGGTGGCCGTGTGTCTGTA	0.428		NA											18	21					4.97e-08	5.51e-08	1	0
HELT	391723	broad.mit.edu	37	4	185940787	185940787	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:185940787C>T	uc011ckq.1	+	3	274	c.274C>T	c.(274-276)CAG>TAG	p.Q92*	HELT_uc011cko.1_Intron|HELT_uc003ixa.3_Intron|HELT_uc011ckp.1_5'UTR	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	92	Helix-loop-helix motif.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GGGCGAACCTCAGGAGGCTCT	0.746		NA											3	13					0	0	0	0
TIMD4	91937	broad.mit.edu	37	5	156346537	156346537	+	Silent	SNP	T	T	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr5:156346537T>A	uc003lwh.2	-	9	1125	c.1068A>T	c.(1066-1068)GGA>GGT	p.G356G	TIMD4_uc010jii.2_Silent_p.G328G|TIMD4_uc003lwg.2_Silent_p.G58G	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	356	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTACTATCTCCAATGTAGT	0.423		NA											19	37					0	0	0	0
OSTM1	28962	broad.mit.edu	37	6	108370556	108370556	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:108370556G>A	uc003psd.2	-	5	936	c.850C>T	c.(850-852)CCT>TCT	p.P284S		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	284	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		GCAATTACAGGCACTGTGTCA	0.398		NA											20	119					0	0	0	0
LACE1	246269	broad.mit.edu	37	6	108645100	108645100	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:108645100G>A	uc003psj.2	+	2	397	c.211G>A	c.(211-213)GTT>ATT	p.V71I		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	71							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		AGCTTTGGCCGTTTGCCATGG	0.398		NA											118	74					0	0	0	0
ACAT2	39	broad.mit.edu	37	6	160199796	160199796	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:160199796C>T	uc010kjy.2	+	9	1260	c.1129C>T	c.(1129-1131)CGT>TGT	p.R377C	ACAT2_uc011efw.1_Missense_Mutation_p.R406C|TCP1_uc003qsr.2_3'UTR|TCP1_uc003qss.2_3'UTR|TCP1_uc010kjz.2_3'UTR|TCP1_uc003qst.2_3'UTR	NM_005891	NP_005882	Q9BWD1	THIC_HUMAN	acetyl-Coenzyme A acetyltransferase 2	377						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GGGCAGAAGTCGTGGTGTTGC	0.478		NA											33	108					0	0	0	0
TNRC18	84629	broad.mit.edu	37	7	5427413	5427413	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:5427413G>A	uc003soi.3	-	5	2391	c.2042C>T	c.(2041-2043)CCT>CTT	p.P681L	TNRC18_uc010ksx.1_Missense_Mutation_p.P607L	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	681							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AATGCCCACAGGCGGGTGTCG	0.701		NA											20	35					0	0	0	0
TMEM168	64418	broad.mit.edu	37	7	112424255	112424255	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:112424255G>T	uc003vgn.2	-	2	1018	c.626C>A	c.(625-627)GCA>GAA	p.A209E	TMEM168_uc010lju.2_Missense_Mutation_p.A209E|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	209	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						TAACAAAACTGCAAAAATAAC	0.333		NA											11	40					6.4e-05	6.88e-05	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117351685	117351685	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:117351685C>T	uc003vjf.2	-	23	4990	c.4898G>A	c.(4897-4899)AGC>AAC	p.S1633N		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1633										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTATTACTGCTGCTGCTGCT	0.383		NA											4	89					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139165127	139165127	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr8:139165127C>G	uc003yuy.2	-	13	1762	c.1591G>C	c.(1591-1593)GTG>CTG	p.V531L	FAM135B_uc003yux.2_Missense_Mutation_p.V432L|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.V93L|FAM135B_uc003yvb.2_Missense_Mutation_p.V93L	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	531										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACATCTGCCACTGGATATGTC	0.458		NA								HNSCC(54;0.14)			34	125					0	0	0	0
INSL4	3641	broad.mit.edu	37	9	5233853	5233853	+	Silent	SNP	A	A	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:5233853A>G	uc003ziy.2	+	2	501	c.396A>G	c.(394-396)GGA>GGG	p.G132G		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	132					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GTGACGATGGAACTTCAGTTA	0.363		NA											38	99					0	0	0	0
ZNF510	22869	broad.mit.edu	37	9	99522150	99522150	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:99522150G>C	uc004awn.1	-	6	1151	c.962C>G	c.(961-963)TCA>TGA	p.S321*	ZNF510_uc004awo.1_Nonsense_Mutation_p.S321*	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTCCACAGTTGACTTCTCAAA	0.358		NA											24	78					0	0	0	0
TEX10	54881	broad.mit.edu	37	9	103091488	103091488	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:103091488C>A	uc004bas.2	-	7	1774	c.1559G>T	c.(1558-1560)CGG>CTG	p.R520L	TEX10_uc011lvf.1_Missense_Mutation_p.R359L|TEX10_uc011lvg.1_Missense_Mutation_p.R523L	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	520						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TAACAAAGTCCGAACTGGAAG	0.343		NA											52	195					2.82e-22	3.47e-22	1	0
SH2D3C	10044	broad.mit.edu	37	9	130507362	130507362	+	Silent	SNP	G	G	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:130507362G>A	uc004bsc.2	-	7	1423	c.1281C>T	c.(1279-1281)GCC>GCT	p.A427A	SH2D3C_uc010mxo.2_Silent_p.A267A|SH2D3C_uc004bry.2_Silent_p.A269A|SH2D3C_uc004brz.3_Silent_p.A73A|SH2D3C_uc011mak.1_Silent_p.A73A|SH2D3C_uc004bsa.2_Silent_p.A270A|SH2D3C_uc004bsb.2_Silent_p.A359A	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	427					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CTGCAGGGGCGGCATGGACAC	0.622		NA											24	37					0	0	0	0
CACNA1B	774	broad.mit.edu	37	9	140811748	140811748	+	Silent	SNP	C	C	T			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:140811748C>T	uc004cog.2	+	6	976	c.831C>T	c.(829-831)TGC>TGT	p.C277C		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	277	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCCGGCTGTGCGAGGGCGACA	0.572		NA											43	54					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21534662	21534662	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chrX:21534662C>G	uc004czx.1	+	9	906	c.870C>G	c.(868-870)ATC>ATG	p.I290M	CNKSR2_uc004czw.2_Missense_Mutation_p.I290M|CNKSR2_uc011mjn.1_Intron|CNKSR2_uc011mjo.1_Missense_Mutation_p.I290M	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	290	PDZ.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						GTGGTGTTATCTTAACTTTGA	0.433		NA											29	15					0	0	0	0
ATRX	546	broad.mit.edu	37	X	76776335	76776335	+	Silent	SNP	T	T	C			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chrX:76776335T>C	uc004ecp.3	-	34	7363	c.7131A>G	c.(7129-7131)CAA>CAG	p.Q2377Q	ATRX_uc004ecq.3_Silent_p.Q2339Q|ATRX_uc004eco.3_Silent_p.Q2162Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2377					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CCTGGCTGGCTTGTCTACTTA	0.378		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						17	10					0	0	0	0
DDIT4	54541	broad.mit.edu	37	10	74034470	74034470	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:74034470delG	uc001jsx.1	+	3	425	c.223delG	c.(223-225)GGGfs	p.G75fs		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	75					apoptosis					pancreas(1)	1						TTACCTGGATGGGGTGTCGTT	0.587		NA											64	133	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578527	7578527	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:7578527delA	uc002gim.2	-	5	597	c.403delT	c.(403-405)TGCfs	p.C135fs	TP53_uc002gig.1_Frame_Shift_Del_p.C135fs|TP53_uc002gih.2_Frame_Shift_Del_p.C135fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C3fs|TP53_uc010cng.1_Frame_Shift_Del_p.C3fs|TP53_uc002gii.1_Frame_Shift_Del_p.C3fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C135fs|TP53_uc010cni.1_Frame_Shift_Del_p.C135fs|TP53_uc002gij.2_Frame_Shift_Del_p.C135fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C42fs|TP53_uc002gio.2_Frame_Shift_Del_p.C3fs|TP53_uc010vug.1_Frame_Shift_Del_p.C96fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(49)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCAGTTGGCAAAACATCTTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	11	---	---	---	---	NA	NA	NA	NA
ME1	4199	broad.mit.edu	37	6	83937086	83937091	+	In_Frame_Del	DEL	ATTCTG	ATTCTG	-			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:83937086_83937091delATTCTG	uc003pjy.2	-	11	1344_1349	c.1238_1243delCAGAAT	c.(1237-1245)GCAGAATGT>GGT	p.413_415AEC>G	ME1_uc011dzb.1_In_Frame_Del_p.338_340AEC>G|ME1_uc011dzc.1_In_Frame_Del_p.247_249AEC>G	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	413_415					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TCTGCAGAACATTCTGCTTTGCTAGT	0.35		NA											8	43	---	---	---	---	NA	NA	NA	NA
GRIK2	2898	broad.mit.edu	37	6	102503431	102503432	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:102503431_102503432insA	uc003pqp.3	+	15	2787_2788	c.2538_2539insA	c.(2536-2541)TCCAAAfs	p.S846fs	GRIK2_uc003pqo.3_Frame_Shift_Ins_p.S846fs|GRIK2_uc010kcw.2_Frame_Shift_Ins_p.S846fs	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	846_847	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TATACAAATCCAAAAAAAACGC	0.351		NA											66	140	---	---	---	---	NA	NA	NA	NA
DCBLD1	285761	broad.mit.edu	37	6	117865742	117865742	+	Splice_Site	DEL	T	T	-			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:117865742delT	uc003pxs.2	+	13	1620	c.1495_splice	c.e13+2	p.D499_splice	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Splice_Site_p.Q497_splice|DCBLD1_uc003pxt.1_Splice_Site_p.D154_splice	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1						cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		AGAAAACAGGTTGGTTGAAAA	0.393		NA											13	45	---	---	---	---	NA	NA	NA	NA
ZNF251	90987	broad.mit.edu	37	8	145947838	145947839	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr8:145947838_145947839delTC	uc003zdv.3	-	5	1462_1463	c.1206_1207delGA	c.(1204-1209)GAGAAAfs	p.E402fs		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	402_403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACATAGGGTTTCTCTCCAGTAT	0.441		NA											45	214	---	---	---	---	NA	NA	NA	NA
