Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
COL11A1	1301	broad.mit.edu	37	1	103405905	103405905	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:103405905G>C	uc001dul.2	-	43	3680	c.3362C>G	c.(3361-3363)TCC>TGC	p.S1121C	COL11A1_uc001duk.2_Missense_Mutation_p.S317C|COL11A1_uc001dum.2_Missense_Mutation_p.S1133C|COL11A1_uc001dun.2_Missense_Mutation_p.S1082C|COL11A1_uc009weh.2_Missense_Mutation_p.S1005C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1121	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCCCCAGGGGAGCCGGCAGG	0.473		NA											17	33					0	0	0	0
TMOD4	29765	broad.mit.edu	37	1	151143016	151143016	+	Missense_Mutation	SNP	T	T	C	rs143662204	byFrequency	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:151143016T>C	uc001exc.3	-	9	1184	c.994A>G	c.(994-996)ATG>GTG	p.M332V	TMOD4_uc001exb.2_Missense_Mutation_p.M160V|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Missense_Mutation_p.M263V	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	332					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTTCGGGTCATGGCCTGGGCT	0.542		NA											6	123					0	0	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954641	161954641	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:161954641T>C	uc001gbu.2	-	7	2028	c.1604A>G	c.(1603-1605)TAC>TGC	p.Y535C	OLFML2B_uc001gbt.2_Missense_Mutation_p.Y18C|OLFML2B_uc010pkq.1_Missense_Mutation_p.Y536C	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	535	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGTGTTGCCGTAGTAATAGTT	0.542		NA											42	79					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63851924	63851924	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:63851924C>T	uc001jlt.1	+	10	2728	c.2702C>T	c.(2701-2703)ACG>ATG	p.T901M		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	901					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAGCCCCTACGGATGATCAG	0.552		NA											28	46					0	0	0	0
KCNMA1	3778	broad.mit.edu	37	10	78708933	78708933	+	Silent	SNP	C	C	T	rs143184179	by1000genomes	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:78708933C>T	uc001jxn.2	-	22	2853	c.2676G>A	c.(2674-2676)ACG>ACA	p.T892T	KCNMA1_uc001jxj.2_Silent_p.T838T|KCNMA1_uc001jxk.1_Silent_p.T510T|KCNMA1_uc009xrt.1_Silent_p.T683T|KCNMA1_uc001jxl.1_Silent_p.T517T|KCNMA1_uc001jxo.2_Silent_p.T875T|KCNMA1_uc001jxm.2_Silent_p.T834T|KCNMA1_uc001jxq.2_Silent_p.T837T	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	892	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGTTATGAAGCGTCTCCCATT	0.458		NA											5	117					0	0	0	0
ENTPD1	953	broad.mit.edu	37	10	97607265	97607265	+	Silent	SNP	C	C	T	rs149509898	by1000genomes	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:97607265C>T	uc001klh.3	+	7	1200	c.876C>T	c.(874-876)AAC>AAT	p.N292N	ENTPD1_uc001kli.3_Silent_p.N299N|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Silent_p.N304N|ENTPD1_uc010qok.1_Silent_p.N184N|ENTPD1_uc010qol.1_Silent_p.N184N|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Silent_p.N154N|ENTPD1_uc009xva.2_Silent_p.N154N|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	292	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGGTAGTGAACGTAAGTGACC	0.418		NA											26	46					0	0	0	0
ELP4	26610	broad.mit.edu	37	11	31616337	31616337	+	Silent	SNP	T	T	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:31616337T>A	uc001mtb.2	+	4	437	c.402T>A	c.(400-402)CTT>CTA	p.L134L	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.L134L|ELP4_uc010rdz.1_Silent_p.L134L	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	134					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CACCATTACTTGATGATAAAT	0.289		NA											11	26					0	0	0	0
QSER1	79832	broad.mit.edu	37	11	32955375	32955375	+	Missense_Mutation	SNP	T	T	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:32955375T>A	uc001mty.2	+	4	2451	c.2184T>A	c.(2182-2184)GAT>GAA	p.D728E	QSER1_uc001mtz.1_Missense_Mutation_p.D489E|QSER1_uc001mua.2_Missense_Mutation_p.D233E	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	728	Gln-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TCCTTTTAGATTCTGCCTGTG	0.408		NA											28	49					0	0	0	0
ABTB2	25841	broad.mit.edu	37	11	34176283	34176283	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:34176283C>T	uc001mvl.1	-	15	2403	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	725							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				TCCATGGATTCTGTTCCTCCG	0.592		NA											24	45					0	0	0	0
OR5L1	219437	broad.mit.edu	37	11	55578997	55578997	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:55578997G>A	uc001nhw.1	+	1	55	c.55G>A	c.(55-57)GAT>AAT	p.D19N		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGGACTATCAGATGTCCCTGA	0.443		NA											14	113					0	0	0	0
NOX4	50507	broad.mit.edu	37	11	89088181	89088181	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:89088181G>C	uc001pct.2	-	13	1405	c.1166C>G	c.(1165-1167)TCT>TGT	p.S389C	NOX4_uc009yvr.2_Missense_Mutation_p.S364C|NOX4_uc001pcu.2_Missense_Mutation_p.S315C|NOX4_uc001pcw.2_Missense_Mutation_p.S82C|NOX4_uc001pcx.2_Missense_Mutation_p.S82C|NOX4_uc001pcv.2_Missense_Mutation_p.S389C|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.S223C|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Missense_Mutation_p.S365C|NOX4_uc009yvq.2_Missense_Mutation_p.S365C	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	389	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GTCTTGACTAGATGGAGGCAG	0.363		NA											6	22					0	0	0	0
IQSEC3	440073	broad.mit.edu	37	12	247484	247484	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr12:247484G>A	uc001qhw.1	+	1	52	c.46G>A	c.(46-48)GCT>ACT	p.A16T	IQSEC3_uc001qhu.1_Missense_Mutation_p.A16T|IQSEC3_uc001qht.1_Missense_Mutation_p.A101T|uc001qhv.1_RNA	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	319	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCGGCGCGCCGCTTGCACCAT	0.592		NA											8	128					0	0	0	0
PGAM5	192111	broad.mit.edu	37	12	133294060	133294060	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr12:133294060G>A	uc009zyv.2	+	3	433	c.406G>A	c.(406-408)GCA>ACA	p.A136T	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Missense_Mutation_p.A136T	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	136						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GCTCCGCCTGGCAAGCTTGGG	0.453		NA											3	31					0	0	0	0
NALCN	259232	broad.mit.edu	37	13	101997763	101997763	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr13:101997763G>T	uc001vox.1	-	7	842	c.653C>A	c.(652-654)ACC>AAC	p.T218N	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.T218N|NALCN_uc001vpa.2_Missense_Mutation_p.T218N	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	218	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACTATTCCAGGTTACATTCCT	0.373		NA											20	34					5.04e-11	5.75e-11	1	0
FBLN5	10516	broad.mit.edu	37	14	92336584	92336584	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr14:92336584G>A	uc001xzx.3	-	11	1804	c.1331C>T	c.(1330-1332)TCG>TTG	p.S444L	TC2N_uc001xzv.3_5'Flank|FBLN5_uc010aud.2_Missense_Mutation_p.S449L|FBLN5_uc010aue.2_Missense_Mutation_p.S485L|FBLN5_uc001xzw.2_RNA	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	444					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				TGGGTACTGCGACACATATAT	0.542		NA											26	51					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28375741	28375741	+	Splice_Site	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:28375741C>T	uc001zbj.2	-	82	12677	c.12571_splice	c.e82-1	p.I4191_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAGAATCAATCTAGAGGGGGA	0.413		NA											43	72					0	0	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42133017	42133017	+	Missense_Mutation	SNP	G	G	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:42133017G>T	uc010bco.2	+	4	366	c.265G>T	c.(265-267)GAT>TAT	p.D89Y	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.D320Y|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.D320Y|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	89	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GGTGACCGGAGATGACCCTGT	0.577		NA											29	41					3.73e-12	4.29e-12	1	0
GCOM1	145781	broad.mit.edu	37	15	57913836	57913836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:57913836C>T	uc002aei.2	+	4	468	c.349C>T	c.(349-351)CGA>TGA	p.R117*	GCOM1_uc002aej.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aek.2_Intron|GCOM1_uc002ael.2_Intron|GCOM1_uc002aem.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	117	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						GGTGAGAAAGCGAATGTATGG	0.403		NA											23	53					0	0	0	0
BTBD12	84464	broad.mit.edu	37	16	3645643	3645643	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:3645643G>A	uc002cvp.2	-	9	2603	c.1976C>T	c.(1975-1977)TCG>TTG	p.S659L		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	659	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTTGTCCTGCGATGGCACCAC	0.632		NA						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				9	21					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65032649	65032649	+	Silent	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:65032649G>A	uc002eoi.2	-	4	773	c.339C>T	c.(337-339)ACC>ACT	p.T113T	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.T113T|CDH11_uc010vin.1_5'UTR|CDH11_uc010vio.1_Silent_p.T113T	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	113	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCAACGTCTTGGTGGCATGAA	0.493		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	6					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10448712	10448712	+	Silent	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:10448712C>T	uc010coi.2	-	5	584	c.456G>A	c.(454-456)CCG>CCA	p.P152P	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.P152P|MYH2_uc010coj.2_Silent_p.P152P	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	152	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGATGTGGGGCGGGGCCTCCT	0.542		NA											10	96					0	0	0	0
CA4	762	broad.mit.edu	37	17	58233927	58233927	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:58233927T>C	uc002iym.3	+	3	213	c.119T>C	c.(118-120)GTC>GCC	p.V40A	CA4_uc010wou.1_RNA	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	40					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TCAGTGCCAGTCAAGTGGGGT	0.587		NA											17	35					0	0	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319570	43319570	+	Missense_Mutation	SNP	A	A	G			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr18:43319570A>G	uc010xcn.1	+	9	1208	c.889A>G	c.(889-891)ATG>GTG	p.M297V	SLC14A1_uc010dnk.2_Missense_Mutation_p.M353V|SLC14A1_uc002lbf.3_Missense_Mutation_p.M297V|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.M192V|SLC14A1_uc002lbh.3_Missense_Mutation_p.M189V|SLC14A1_uc002lbi.3_Missense_Mutation_p.M165V|SLC14A1_uc002lbj.3_Missense_Mutation_p.M353V|SLC14A1_uc002lbk.3_Missense_Mutation_p.M297V	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	297	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						CTGCATTGCAATGGGAGGAAT	0.562		NA											26	44					0	0	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456253	5456253	+	Missense_Mutation	SNP	G	G	A	rs113345491		TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr19:5456253G>A	uc002mca.3	+	1	828	c.751G>A	c.(751-753)GTG>ATG	p.V251M		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	251	Helical; (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTGTCACCCCGTGCTGACCGT	0.682		NA											25	19					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57175924	57175924	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr19:57175924C>T	uc010ygo.1	-	2	709	c.709G>A	c.(709-711)GTG>ATG	p.V237M	ZNF835_uc010ygn.1_Missense_Mutation_p.V215M	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CCCGTGTGCACGCGCCGGTGC	0.716		NA											5	9					0	0	0	0
ALK	238	broad.mit.edu	37	2	29455179	29455179	+	Missense_Mutation	SNP	C	C	T	rs148001139		TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:29455179C>T	uc002rmy.2	-	15	3530	c.2623G>A	c.(2623-2625)GGA>AGA	p.G875R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	875	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTGCGGCTCCGGAATTGCCG	0.617		NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	91					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166848284	166848284	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:166848284G>A	uc010zcz.1	-	26	5486	c.5468C>T	c.(5467-5469)GCG>GTG	p.A1823V		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1834						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CGGTTCAAGCGCAGCTGCAAA	0.458		NA											43	64					0	0	0	0
CDK15	65061	broad.mit.edu	37	2	202700438	202700438	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:202700438C>T	uc002uyt.2	+	8	852	c.803C>T	c.(802-804)CCT>CTT	p.P268L	CDK15_uc010ftm.2_Missense_Mutation_p.P133L|CDK15_uc002uys.2_Missense_Mutation_p.P217L|CDK15_uc010ftn.1_Missense_Mutation_p.P217L|CDK15_uc010fto.1_Missense_Mutation_p.P247L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	268	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	TACCGGCCCCCTGATGCTTTG	0.522		NA											15	29					0	0	0	0
MAP2	4133	broad.mit.edu	37	2	210594941	210594941	+	Silent	SNP	T	T	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:210594941T>A	uc002vde.1	+	15	5552	c.5304T>A	c.(5302-5304)GCT>GCA	p.A1768A	MAP2_uc002vdd.1_Silent_p.A500A|MAP2_uc002vdf.1_Silent_p.A443A|MAP2_uc002vdg.1_Silent_p.A412A|MAP2_uc002vdh.1_Silent_p.A469A|MAP2_uc002vdi.1_Silent_p.A1764A	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1768					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GAGAGCATGCTAAAGCCCGTG	0.512		NA											9	17					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	228009238	228009238	+	Silent	SNP	T	T	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:228009238T>A	uc010zlt.1	-	3	762	c.108A>T	c.(106-108)GTA>GTT	p.V36V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	36					axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTACCCCATATACATATTGTA	0.269		NA											19	45					0	0	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20506898	20506898	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr20:20506898C>T	uc002wrz.2	-	28	3834	c.3691G>A	c.(3691-3693)GAA>AAA	p.E1231K	RALGAPA2_uc010gcx.2_Missense_Mutation_p.E935K|RALGAPA2_uc010zsg.1_Missense_Mutation_p.E679K|RALGAPA2_uc002wsa.1_Missense_Mutation_p.E3K	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1231					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						AGACTTACTTCTGCCATTTTC	0.353		NA											7	11					0	0	0	0
BIK	638	broad.mit.edu	37	22	43524565	43524565	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr22:43524565G>A	uc003bdk.2	+	4	384	c.324G>A	c.(322-324)ATG>ATA	p.M108I		NM_001197	NP_001188	Q13323	BIK_HUMAN	BCL2-interacting killer	108					apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane					0		Ovarian(80;0.0694)				GAAGTTTCATGGACGGTTTCA	0.512		NA											27	67					0	0	0	0
SENP2	59343	broad.mit.edu	37	3	185316239	185316239	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr3:185316239C>T	uc003fpn.2	+	3	368	c.197C>T	c.(196-198)GCT>GTT	p.A66V	SENP2_uc011brv.1_Missense_Mutation_p.A56V|SENP2_uc011brw.1_5'UTR	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	66					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CTCTACAATGCTGCCAGCTTA	0.393		NA											11	36					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20597445	20597445	+	Missense_Mutation	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr4:20597445C>T	uc003gpr.1	+	31	3512	c.3308C>T	c.(3307-3309)CCC>CTC	p.P1103L	SLIT2_uc003gps.1_Missense_Mutation_p.P1095L	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1103	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGCATATGCCCCGAAGGTTAC	0.303		NA											19	36					0	0	0	0
CHD1	1105	broad.mit.edu	37	5	98233988	98233988	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:98233988G>T	uc003knf.2	-	9	1485	c.1337C>A	c.(1336-1338)TCA>TAA	p.S446*		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	446	Chromo 2.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	AGTGGTTTTTGATTGGTTCCT	0.323		NA											9	31					0.000442599	0.000475057	1	0
PCDHA11	56138	broad.mit.edu	37	5	140250616	140250616	+	Missense_Mutation	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:140250616G>A	uc003lia.2	+	1	2786	c.1928G>A	c.(1927-1929)CGC>CAC	p.R643H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R643H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	643	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTCGCCGCGCCACCGACTT	0.687		NA											20	41					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150922619	150922619	+	Missense_Mutation	SNP	T	T	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:150922619T>C	uc003lue.3	-	9	8082	c.8069A>G	c.(8068-8070)AAA>AGA	p.K2690R	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2690	Cadherin 23.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGAAAATTTCGGTAAGGA	0.463		NA											26	40					0	0	0	0
POLB	5423	broad.mit.edu	37	8	42196204	42196204	+	Splice_Site	SNP	G	G	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:42196204G>T	uc003xoz.1	+	1	174	c.61_splice	c.e1+1	p.E21_splice	POLB_uc003xpa.1_Splice_Site_p.E21_splice|POLB_uc011lcs.1_Splice_Site	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta						DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	ATGCTCACAGGTTAGCACCGG	0.617		NA						DNA_polymerases_(catalytic_subunits)					31	56					1.16e-09	1.32e-09	1	0
GPAA1	8733	broad.mit.edu	37	8	145139221	145139221	+	Silent	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:145139221G>A	uc003zax.2	+	6	911	c.801G>A	c.(799-801)ACG>ACA	p.T267T	GPAA1_uc003zav.1_Silent_p.T145T|GPAA1_uc003zaw.1_Silent_p.T207T	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	267	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGTTGTGCACGCTTCAGGGCA	0.627		NA											17	48					0	0	0	0
NFKBIL2	4796	broad.mit.edu	37	8	145655883	145655883	+	Silent	SNP	G	G	A			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:145655883G>A	uc011llg.1	-	25	3862	c.3847C>T	c.(3847-3849)CTG>TTG	p.L1283L	VPS28_uc003zcs.1_5'Flank|VPS28_uc003zct.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1283	LRR 6.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TTGGCAGACAGATCCAGTGAG	0.557		NA											6	12					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90501079	90501079	+	Silent	SNP	C	C	T			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr9:90501079C>T	uc004app.3	+	4	1712	c.1677C>T	c.(1675-1677)GTC>GTT	p.V559V	C9orf79_uc004apo.1_Silent_p.V371V	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	559						integral to membrane				ovary(3)	3						CACAGTCTGTCATCCCCACTG	0.483		NA											11	139					0	0	0	0
WDR5	11091	broad.mit.edu	37	9	137005026	137005026	+	Missense_Mutation	SNP	G	G	C			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr9:137005026G>C	uc004cey.2	+	2	198	c.27G>C	c.(25-27)GAG>GAC	p.E9D	WDR5_uc004cez.2_Missense_Mutation_p.E9D	NM_017588	NP_060058	P61964	WDR5_HUMAN	WD repeat domain 5	9					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		AGAAGCCCGAGACCGAGGCCG	0.657		NA											11	22					0	0	0	0
CHD4	1108	broad.mit.edu	37	12	6711145	6711147	+	In_Frame_Del	DEL	TCC	TCC	-	rs1639122	byFrequency	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr12:6711145_6711147delTCC	uc001qpo.2	-	4	581_583	c.417_419delGGA	c.(415-420)GAGGAT>GAT	p.E139del	CHD4_uc001qpn.2_In_Frame_Del_p.E132del|CHD4_uc001qpp.2_In_Frame_Del_p.E136del	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	139	Poly-Asp.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCATCATCAtcctcctcctcct	0.384		NA											27	286	---	---	---	---	NA	NA	NA	NA
SMG1	23049	broad.mit.edu	37	16	18856797	18856807	+	Frame_Shift_Del	DEL	GGAGTCTTCAG	GGAGTCTTCAG	-			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:18856797_18856807delGGAGTCTTCAG	uc002dfm.2	-	39	6526_6536	c.6163_6173delCTGAAGACTCC	c.(6163-6174)CTGAAGACTCCAfs	p.L2055fs	SMG1_uc010bwb.2_Frame_Shift_Del_p.L1915fs|SMG1_uc010bwa.2_Frame_Shift_Del_p.L786fs|SMG1_uc002dfo.3_Frame_Shift_Del_p.L353fs	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2055_2058					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AGGGTTCAATGGAGTCTTCAGTTTTTCTAGG	0.455		NA											14	40	---	---	---	---	NA	NA	NA	NA
KIAA0100	9703	broad.mit.edu	37	17	26971123	26971123	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:26971123delA	uc002hbu.2	-	2	250	c.151delT	c.(151-153)TGGfs	p.W51fs	KIAA0100_uc002hbv.2_Frame_Shift_Del_p.W51fs|KIAA0100_uc010crr.1_5'UTR	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	51						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTCTGGATCCAAAAAAAGCGG	0.478		NA									OREG0024280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	136	---	---	---	---	NA	NA	NA	NA
