Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	G	T	rs148273194	by1000genomes	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:12885289G>T	uc001auk.2	-	4	1018	c.822C>A	c.(820-822)CTC>CTA	p.L274L		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	274	LRR 3.										0						GGCACTGGGAGAGATGCTTCA	0.458		NA											7	175					0.00448238	0.00461855	1	0
KIF17	57576	broad.mit.edu	37	1	21031194	21031194	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:21031194G>A	uc001bdr.3	-	5	987	c.869C>T	c.(868-870)TCG>TTG	p.S290L	KIF17_uc001bds.3_Missense_Mutation_p.S290L	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	290					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CGTCAGCTTCGAGTCACGGTA	0.622		NA											16	44					0	0	0	0
COL16A1	1307	broad.mit.edu	37	1	32148956	32148956	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:32148956G>A	uc001btk.1	-	35	2759	c.2394C>T	c.(2392-2394)GCC>GCT	p.A798A	COL16A1_uc001btj.1_Silent_p.A627A|COL16A1_uc001btl.3_Silent_p.A798A	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	798	Triple-helical region 5 (COL5) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GCAAACCCGGGGCTCCAGGCT	0.617		NA											45	141					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109795883	109795883	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:109795883C>T	uc001dxa.3	+	1	3243	c.3182C>T	c.(3181-3183)ACT>ATT	p.T1061I		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1061	Cadherin 9.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GATAGTCTGACTTACAGCTTT	0.547		NA											16	43					0	0	0	0
WDR77	79084	broad.mit.edu	37	1	111985333	111985333	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:111985333C>T	uc001ebb.2	-	8	781	c.742G>A	c.(742-744)GTC>ATC	p.V248I	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.V184I	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	248	WD 4.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGCTCAGGACACAGCTTGTA	0.443		NA											5	19					0	0	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075708	145075708	+	Missense_Mutation	SNP	C	C	T	rs148346797	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:145075708C>T	uc001emh.2	-	1	372	c.155G>A	c.(154-156)CGG>CAG	p.R52Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.R52Q|PDE4DIP_uc001emk.2_Missense_Mutation_p.R52Q	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCCGGGCGCCGTCTTTCCCG	0.721		NA	T	PDGFRB	MPD								13	82					0	0	0	0
VHLL	391104	broad.mit.edu	37	1	156268971	156268971	+	Silent	SNP	T	T	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:156268971T>G	uc001fok.2	-	1	458	c.10A>C	c.(10-12)AGA>CGA	p.R4R		NM_001004319	NP_001004319	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	4					protein ubiquitination	nucleus				ovary(1)	1	Hepatocellular(266;0.158)					TTCCCCGCTCTCCAGGGCATT	0.592		NA											22	79					0	0	0	0
KIRREL	55243	broad.mit.edu	37	1	158047906	158047906	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:158047906C>T	uc001frn.3	+	3	732	c.328C>T	c.(328-330)CGG>TGG	p.R110W	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Missense_Mutation_p.R49W	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	110	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCTGCGCTCTCGGCGGGCCAA	0.607		NA											9	117					0	0	0	0
OR10X1	128367	broad.mit.edu	37	1	158549570	158549570	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:158549570C>T	uc010pin.1	-	1	120	c.120G>A	c.(118-120)CAG>CAA	p.Q40Q		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	40	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AAAGAAATGTCTGTACATGTG	0.423		NA											6	78					0	0	0	0
FMO1	2326	broad.mit.edu	37	1	171250015	171250015	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:171250015C>G	uc009wvz.2	+	6	854	c.718C>G	c.(718-720)CAG>GAG	p.Q240E	FMO1_uc010pme.1_Missense_Mutation_p.Q177E|FMO1_uc001ghl.2_Missense_Mutation_p.Q240E|FMO1_uc001ghm.2_Missense_Mutation_p.Q240E|FMO1_uc001ghn.2_Missense_Mutation_p.Q240E	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	240					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GACACGCTTTCAGAACATGTT	0.493		NA											7	68					0	0	0	0
CEP350	9857	broad.mit.edu	37	1	180080243	180080243	+	Missense_Mutation	SNP	A	A	G	rs150197968		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:180080243A>G	uc001gnt.2	+	38	9684	c.9301A>G	c.(9301-9303)ATT>GTT	p.I3101V	CEP350_uc009wxl.2_Missense_Mutation_p.I3100V|CEP350_uc001gnv.2_Missense_Mutation_p.I1236V|CEP350_uc001gnw.1_Missense_Mutation_p.I858V|CEP350_uc001gnx.1_Missense_Mutation_p.I858V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3101						centrosome|nucleus|spindle				ovary(4)	4						CAAAGATACTATTGATGTTCT	0.463		NA											15	29					0	0	0	0
PPFIA4	8497	broad.mit.edu	37	1	203013095	203013095	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:203013095C>T	uc009xaj.2	+	8	814	c.814C>T	c.(814-816)CAT>TAT	p.H272Y	PPFIA4_uc010pqf.1_5'Flank			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGTGTCCCGCCATGAACGGTC	0.622		NA											8	31					0	0	0	0
FCAMR	83953	broad.mit.edu	37	1	207135705	207135705	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:207135705G>A	uc001hfa.3	-	5	1005	c.505C>T	c.(505-507)CGT>TGT	p.R169C	FCAMR_uc001hfb.2_Missense_Mutation_p.R169C|FCAMR_uc009xca.1_Missense_Mutation_p.R169C|FCAMR_uc001hfc.2_Missense_Mutation_p.R144C	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	124	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGGGCCACACGGTCACGATAG	0.572		NA											28	41					0	0	0	0
GPR137B	7107	broad.mit.edu	37	1	236341831	236341831	+	Silent	SNP	A	A	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:236341831A>T	uc001hxq.2	+	3	673	c.582A>T	c.(580-582)CGA>CGT	p.R194R	GPR137B_uc001hxr.1_5'UTR|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	194	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TCTCTGTGCGAGTGGCCATTA	0.473		NA											27	54					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237969504	237969504	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:237969504C>T	uc001hyl.1	+	99	14339	c.14219C>T	c.(14218-14220)GCC>GTC	p.A4740V	RYR2_uc010pyb.1_Missense_Mutation_p.A173V	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4740	Helical; Name=M7; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTTTTTTGCCGCTCACCTT	0.403		NA											3	29					0	0	0	0
LYZL2	119180	broad.mit.edu	37	10	30915048	30915048	+	Missense_Mutation	SNP	T	T	C	rs143775752	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:30915048T>C	uc001ivk.2	-	3	435	c.422A>G	c.(421-423)CAC>CGC	p.H141R		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	95					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				GCAGGCGACGTGGCAGTGGTT	0.557		NA											11	54					0	0	0	0
ZNF438	220929	broad.mit.edu	37	10	31133973	31133973	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:31133973C>G	uc010qdz.1	-	8	2839	c.2404G>C	c.(2404-2406)GAG>CAG	p.E802Q	ZNF438_uc001ivn.2_Missense_Mutation_p.E753Q|ZNF438_uc010qdy.1_Missense_Mutation_p.E792Q|ZNF438_uc001ivo.3_Missense_Mutation_p.E366Q|ZNF438_uc009xlg.2_Missense_Mutation_p.E802Q|ZNF438_uc001ivp.3_Missense_Mutation_p.E792Q|ZNF438_uc010qea.1_Missense_Mutation_p.E802Q|ZNF438_uc010qeb.1_Missense_Mutation_p.E802Q	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GAAGGGTCCTCACAGTTATGC	0.517		NA											7	184					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506697	37506697	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:37506697G>C	uc001iza.1	+	33	3089	c.2990G>C	c.(2989-2991)GGA>GCA	p.G997A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1053	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAAGAATTAGGAAGAATCGAA	0.318		NA											3	40					0	0	0	0
ALOX5	240	broad.mit.edu	37	10	45941026	45941026	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:45941026G>A	uc001jce.2	+	14	2015	c.1916G>A	c.(1915-1917)CGC>CAC	p.R639H	ALOX5_uc009xmt.2_Missense_Mutation_p.R607H|ALOX5_uc010qfg.1_Missense_Mutation_p.R582H	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	639	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	GCCCGATTCCGCAAGAACCTC	0.532		NA											7	52					0	0	0	0
CTNNA3	29119	broad.mit.edu	37	10	67829147	67829147	+	Missense_Mutation	SNP	A	A	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:67829147A>T	uc009xpn.1	-	15	2201	c.2078T>A	c.(2077-2079)ATA>AAA	p.I693K	CTNNA3_uc001jmw.2_Missense_Mutation_p.I693K	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	693					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						ATCATCCCATATCTCAATCTC	0.403		NA											35	91					0	0	0	0
WAPAL	23063	broad.mit.edu	37	10	88232379	88232379	+	Missense_Mutation	SNP	T	T	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:88232379T>A	uc001kdo.2	-	6	2325	c.1883A>T	c.(1882-1884)GAA>GTA	p.E628V	WAPAL_uc009xsv.2_5'Flank|WAPAL_uc001kdn.2_Missense_Mutation_p.E665V|WAPAL_uc009xsw.2_Missense_Mutation_p.E622V	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	628	Mediates interaction with the cohesin complex.|WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTCTTTGTCTTCTCGTCTGCA	0.358		NA											9	35					0	0	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99211482	99211482	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:99211482G>A	uc001knj.2	+	3	399	c.50G>A	c.(49-51)CGC>CAC	p.R17H	ZDHHC16_uc001knp.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knk.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knl.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knm.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knn.2_Missense_Mutation_p.R17H|ZDHHC16_uc010qow.1_Missense_Mutation_p.R17H|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_Missense_Mutation_p.R17H|ZDHHC16_uc009xvr.2_Missense_Mutation_p.R17H	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	17	Cytoplasmic (Potential).				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		CTCTGCCTCCGCCTCCTTCTG	0.667		NA											16	23					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	106976783	106976783	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:106976783C>G	uc001kyi.1	+	19	2864	c.2637C>G	c.(2635-2637)ATC>ATG	p.I879M	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	879	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGGACGGCATCAAGCACGTGT	0.517		NA											13	35					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	117884986	117884986	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:117884986C>T	uc001lcj.2	-	6	1214	c.516G>A	c.(514-516)TCG>TCA	p.S172S	GFRA1_uc001lci.2_Silent_p.S167S|GFRA1_uc009xyr.2_Silent_p.S167S	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	172	2				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGATGTACGCCGACCTGTACT	0.577		NA											12	28					0	0	0	0
PSMA1	5682	broad.mit.edu	37	11	14526746	14526746	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:14526746C>T	uc001mlk.2	-	10	930	c.784G>A	c.(784-786)GAA>AAA	p.E262K	PSMA1_uc001mll.2_Missense_Mutation_p.E268K|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.E237K	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	262					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						ACTTAATGTTCCATTGGTTCA	0.333		NA											26	70					0	0	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195639	18195639	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:18195639G>C	uc001mnv.1	+	1	1256	c.836G>C	c.(835-837)AGG>ACG	p.R279T		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	279	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCTCCTTTAGGCAGCGTCAA	0.488		NA											13	66					0	0	0	0
IGSF22	283284	broad.mit.edu	37	11	18735568	18735568	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:18735568G>T	uc009yht.2	-	14	2116	c.1926C>A	c.(1924-1926)TAC>TAA	p.Y642*	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	642	Ig-like 4.									ovary(4)|large_intestine(2)|kidney(1)	7						TGCCATCCTTGTACCATGTCA	0.602		NA											24	64					9.86e-18	1.14e-17	1	0
ANO5	203859	broad.mit.edu	37	11	22257816	22257816	+	Silent	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:22257816C>A	uc001mqi.2	+	8	1073	c.756C>A	c.(754-756)CTC>CTA	p.L252L	ANO5_uc001mqj.2_Silent_p.L251L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	252	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CCTATCCACTCCATGATGTAT	0.383		NA											11	37					5.17e-11	5.83e-11	1	0
TCP11L1	55346	broad.mit.edu	37	11	33083210	33083210	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:33083210G>A	uc001mud.2	+	7	1310	c.910G>A	c.(910-912)GTC>ATC	p.V304I	TCP11L1_uc009yju.2_Missense_Mutation_p.V119I|TCP11L1_uc010rei.1_Missense_Mutation_p.V304I|TCP11L1_uc001mue.2_Missense_Mutation_p.V304I|TCP11L1_uc001muf.1_RNA	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	304											0						CCCTGTTGCTGTCCAGAATTA	0.547		NA											5	17					0	0	0	0
OR4C11	219429	broad.mit.edu	37	11	55371357	55371357	+	Missense_Mutation	SNP	G	G	A	rs141808171	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:55371357G>A	uc010rii.1	-	1	493	c.493C>T	c.(493-495)CCT>TCT	p.P165S		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACAGAAAGGCAATCTTAAG	0.443		NA											16	14					0	0	0	0
OR5D13	390142	broad.mit.edu	37	11	55541352	55541352	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:55541352G>T	uc010ril.1	+	1	439	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCTCTTCTGGTGGCTGGGTC	0.403		NA											15	137					2e-07	2.22e-07	1	0
PC	5091	broad.mit.edu	37	11	66617416	66617416	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:66617416G>A	uc001ojn.1	-	18	2939	c.2890C>T	c.(2890-2892)CGC>TGC	p.R964C	PC_uc001ojo.1_Missense_Mutation_p.R964C|PC_uc001ojp.1_Missense_Mutation_p.R964C|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	964					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	ACCTTAGAGCGAAAGGGTTCG	0.627		NA											10	31					0	0	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800175	74800175	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:74800175G>C	uc010rro.1	-	1	584	c.584C>G	c.(583-585)TCT>TGT	p.S195C		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTGGTGTCAGAGCAGGAGGC	0.567		NA											3	34					0	0	0	0
CUL5	8065	broad.mit.edu	37	11	107925516	107925516	+	Missense_Mutation	SNP	A	A	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:107925516A>T	uc001pjv.2	+	6	1363	c.696A>T	c.(694-696)AAA>AAT	p.K232N	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	232					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		ATTATATGAAATATGTAAGTT	0.323		NA											15	25					0	0	0	0
OR10S1	219873	broad.mit.edu	37	11	123848324	123848324	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:123848324G>A	uc001pzm.1	-	1	75	c.75C>T	c.(73-75)TTC>TTT	p.F25F		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTCCAGGAAGAAGTGGCTCA	0.502		NA											6	77					0	0	0	0
NFRKB	4798	broad.mit.edu	37	11	129746654	129746654	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:129746654C>T	uc001qfi.2	-	17	1910	c.1709G>A	c.(1708-1710)CGC>CAC	p.R570H	NFRKB_uc001qfg.2_Missense_Mutation_p.R595H|NFRKB_uc001qfh.2_Missense_Mutation_p.R593H|NFRKB_uc010sbw.1_Missense_Mutation_p.R580H|NFRKB_uc009zcr.2_5'Flank	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	570					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CCGGTCGGAGCGCAGCAGGGA	0.572		NA											8	37					0	0	0	0
COPS7A	50813	broad.mit.edu	37	12	6839587	6839587	+	Missense_Mutation	SNP	G	G	A	rs144125600		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:6839587G>A	uc001qqj.2	+	6	789	c.550G>A	c.(550-552)GTG>ATG	p.V184M	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Missense_Mutation_p.V184M|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Missense_Mutation_p.V184M|COPS7A_uc001qqi.2_Missense_Mutation_p.V184M|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Missense_Mutation_p.V184M|COPS7A_uc001qqo.2_Missense_Mutation_p.V184M	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	184					cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						CTGTGAGGTCGTGCTGTCAGG	0.567		NA											4	73					0	0	0	0
ITPR2	3709	broad.mit.edu	37	12	26493141	26493141	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:26493141C>T	uc001rhg.2	-	56	8395	c.7978G>A	c.(7978-7980)GTC>ATC	p.V2660I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2660	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGCTGTTTGACCAGACTCATG	0.547		NA											18	35					0	0	0	0
ITPR2	3709	broad.mit.edu	37	12	26572049	26572049	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:26572049T>C	uc001rhg.2	-	50	7460	c.7043A>G	c.(7042-7044)TAT>TGT	p.Y2348C	ITPR2_uc009zjg.1_Missense_Mutation_p.Y499C	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2348	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CGCCACGTGATAGAGAAAGGC	0.453		NA											19	51					0	0	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27826759	27826759	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:27826759G>T	uc001ric.1	+	16	1807	c.1430G>T	c.(1429-1431)GGG>GTG	p.G477V	PPFIBP1_uc010sjr.1_Missense_Mutation_p.G308V|PPFIBP1_uc001rib.1_Missense_Mutation_p.G460V|PPFIBP1_uc001ria.2_Missense_Mutation_p.G446V|PPFIBP1_uc001rid.1_Missense_Mutation_p.G324V|PPFIBP1_uc001rif.1_5'Flank	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	477					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ACATCTGATGGGGTGGGTTCT	0.348		NA											11	41					5.17e-11	5.83e-11	1	0
ALG10	84920	broad.mit.edu	37	12	34179307	34179307	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:34179307C>T	uc001rlm.2	+	3	1198	c.879C>T	c.(877-879)TAC>TAT	p.Y293Y		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	293	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				AACTATTCTACTTTTTTTCAT	0.348		NA											43	111					0	0	0	0
OR6C65	403282	broad.mit.edu	37	12	55794794	55794794	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:55794794G>A	uc010spl.1	+	1	482	c.482G>A	c.(481-483)GGC>GAC	p.G161D		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGATTATGGGCCTCCAACTG	0.433		NA											75	163					0	0	0	0
PDX1	3651	broad.mit.edu	37	13	28498614	28498614	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:28498614G>A	uc001urt.2	+	2	736	c.628G>A	c.(628-630)GGC>AGC	p.G210S		NM_000209	NP_000200	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	210				GG -> SS (in Ref. 6; AAC05157).	detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0	all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CAAGAAGCGCGGCGGCGGGAC	0.582		NA											7	16					0	0	0	0
DIS3	22894	broad.mit.edu	37	13	73349468	73349468	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:73349468C>G	uc001vix.3	-	6	1242	c.868G>C	c.(868-870)GAT>CAT	p.D290H	DIS3_uc001viy.3_Missense_Mutation_p.D260H|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	290					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		GCCACAATATCTTCGTGAACA	0.388		NA								Multiple Myeloma(4;0.011)			18	65					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77651324	77651324	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:77651324C>T	uc001vkf.2	-	68	11660	c.11569G>A	c.(11569-11571)GAA>AAA	p.E3857K	MYCBP2_uc010aev.2_Missense_Mutation_p.E3261K|MYCBP2_uc001vke.2_Missense_Mutation_p.E477K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3857	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GTCTCAGCTTCACAGTTCCTC	0.433		NA											14	33					0	0	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455029	84455029	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:84455029G>A	uc001vlk.2	-	1	1500	c.614C>T	c.(613-615)GCG>GTG	p.A205V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	205	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CAGGATCTCCGCAATACCAGG	0.542		NA											22	39					0	0	0	0
CHD8	57680	broad.mit.edu	37	14	21873943	21873943	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:21873943C>T	uc001was.1	-	15	2245	c.2151G>A	c.(2149-2151)CCG>CCA	p.P717P	CHD8_uc001war.1_Silent_p.P613P|CHD8_uc001wav.1_Silent_p.P159P	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	996	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GAAATTGTGACGGTTCCAAGA	0.418		NA											8	130					0	0	0	0
NPAS3	64067	broad.mit.edu	37	14	34263139	34263139	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:34263139G>A	uc001wru.2	+	10	1254	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	NPAS3_uc001wrs.2_Missense_Mutation_p.R384H|NPAS3_uc001wrt.2_Missense_Mutation_p.R365H|NPAS3_uc001wrv.2_Missense_Mutation_p.R367H	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	397	PAC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		AAGTACTATCGCTGGATGCAG	0.373		NA											10	47					0	0	0	0
ITPK1	3705	broad.mit.edu	37	14	93408122	93408122	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:93408122G>A	uc001ybg.2	-	11	1318	c.1029C>T	c.(1027-1029)GCC>GCT	p.A343A	ITPK1_uc001ybe.2_Intron|ITPK1_uc001ybf.2_Silent_p.A224A|ITPK1_uc001ybh.2_Silent_p.A343A	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	343					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		CCGCCGGCTCGGCCAGAAGCT	0.711		NA											4	14					0	0	0	0
ITPK1	3705	broad.mit.edu	37	14	93412800	93412800	+	Missense_Mutation	SNP	G	G	T	rs144084022		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:93412800G>T	uc001ybg.2	-	10	1066	c.777C>A	c.(775-777)GAC>GAA	p.D259E	ITPK1_uc001ybe.2_Missense_Mutation_p.D259E|ITPK1_uc001ybf.2_Missense_Mutation_p.D140E|ITPK1_uc001ybh.2_Missense_Mutation_p.D259E	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	259	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GGATGACCTCGTCGCTCGGCC	0.637		NA											5	41					0.000602214	0.00063008	1	0
AHNAK2	113146	broad.mit.edu	37	14	105409647	105409647	+	Silent	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:105409647G>C	uc010axc.1	-	7	12261	c.12141C>G	c.(12139-12141)CTC>CTG	p.L4047L	AHNAK2_uc001ypx.2_Silent_p.L3947L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4047						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTGCCCTTTGAGGCTGGCTC	0.627		NA											9	200					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33962690	33962690	+	Silent	SNP	T	T	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:33962690T>G	uc001zhi.2	+	38	5863	c.5793T>G	c.(5791-5793)GTT>GTG	p.V1931V	RYR3_uc010bar.2_Silent_p.V1931V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1931	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGCCTTGGTTTACAAAATCA	0.448		NA											10	35					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43815140	43815140	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:43815140G>A	uc001zrt.2	+	4	1936	c.1469G>A	c.(1468-1470)CGT>CAT	p.R490H		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	490	Lys-rich (basic).|9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GACAGGAGCCGTGCTATCCGT	0.542		NA											10	12					0	0	0	0
USP8	9101	broad.mit.edu	37	15	50763974	50763974	+	Silent	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:50763974G>C	uc001zym.3	+	9	1331	c.831G>C	c.(829-831)CTG>CTC	p.L277L	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Silent_p.L277L|USP8_uc001zyn.3_Silent_p.L277L|USP8_uc010ufh.1_Silent_p.L200L|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	277	Rhodanese.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TCCGGAGTCTGAAAGATGCAC	0.393		NA											4	103					0	0	0	0
PRTG	283659	broad.mit.edu	37	15	55931991	55931991	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:55931991G>A	uc002adg.2	-	13	2221	c.2173C>T	c.(2173-2175)CCC>TCC	p.P725S		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	725	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGATGGTGGGGTGGTGGTGGA	0.448		NA											6	63					0	0	0	0
DPP8	54878	broad.mit.edu	37	15	65793046	65793046	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:65793046G>A	uc002aov.2	-	4	2070	c.492C>T	c.(490-492)GTC>GTT	p.V164V	DPP8_uc002aow.2_Silent_p.V164V|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Silent_p.V148V|DPP8_uc002aoy.2_Silent_p.V164V|DPP8_uc002aoz.2_Silent_p.V148V|DPP8_uc010bhj.2_Silent_p.V164V|DPP8_uc002apa.2_Silent_p.V61V	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	164					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						AAGCAATTCCGACTGTTCCAA	0.398		NA											40	82					0	0	0	0
MYO9A	4649	broad.mit.edu	37	15	72119040	72119040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:72119040G>A	uc002atl.3	-	42	8001	c.7528C>T	c.(7528-7530)CAG>TAG	p.Q2510*	MYO9A_uc002atj.2_Nonsense_Mutation_p.Q441*|MYO9A_uc002atk.2_Nonsense_Mutation_p.Q1305*	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2510	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTGGTTTTCTGAGGTGAGTTT	0.478		NA											36	87					0	0	0	0
ADPGK	83440	broad.mit.edu	37	15	73048712	73048712	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:73048712C>T	uc002avg.3	-	5	814	c.720G>A	c.(718-720)ATG>ATA	p.M240I	ADPGK_uc002ave.3_5'UTR|ADPGK_uc010ukw.1_Missense_Mutation_p.M182I|ADPGK_uc002avf.3_Missense_Mutation_p.M240I|ADPGK_uc002avi.3_Missense_Mutation_p.M118I|ADPGK_uc002avh.3_Missense_Mutation_p.M1I	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	240	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						CCAGCATATTCATGGCCCCGT	0.537		NA											5	63					0	0	0	0
RLBP1	6017	broad.mit.edu	37	15	89754989	89754989	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:89754989C>T	uc002bnl.2	-	7	1049	c.669G>A	c.(667-669)ATG>ATA	p.M223I		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	223	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	GCATGTCCACCATCTTCCTGA	0.547		NA											3	40					0	0	0	0
VPS33B	26276	broad.mit.edu	37	15	91542965	91542965	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:91542965G>C	uc002bqp.1	-	22	2070	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L	VPS33B_uc002bqq.1_Missense_Mutation_p.F481L|VPS33B_uc010uqu.1_Missense_Mutation_p.F545L	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	572					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					AACCACCCAAGAACACCACCA	0.507		NA											8	216					0	0	0	0
IFT140	9742	broad.mit.edu	37	16	1614075	1614075	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:1614075C>T	uc002cmb.2	-	17	2352	c.1990G>A	c.(1990-1992)GAA>AAA	p.E664K	IFT140_uc002clz.2_Missense_Mutation_p.E315K	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	664										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGCACGGCTTCGCATACAAAC	0.577		NA											5	53					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3820572	3820572	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:3820572G>C	uc002cvv.2	-	14	3083	c.2879C>G	c.(2878-2880)CCG>CGG	p.P960R	CREBBP_uc002cvw.2_Missense_Mutation_p.P922R	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	960					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GAGGCTTACCGGTGTGCCAGG	0.488		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				54	221					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565237	20565237	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:20565237G>A	uc002dhj.3	-	6	812	c.602C>T	c.(601-603)GCA>GTA	p.A201V	ACSM2B_uc002dhk.3_Missense_Mutation_p.A201V|ACSM2B_uc010bwf.1_Missense_Mutation_p.A201V	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	201					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						AGTGGTGGATGCCTCACTGAC	0.493		NA											14	44					0	0	0	0
FHOD1	29109	broad.mit.edu	37	16	67263809	67263809	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:67263809G>T	uc002esl.2	-	21	3411	c.3299C>A	c.(3298-3300)CCC>CAC	p.P1100H	LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.P159H|FHOD1_uc010ced.2_Missense_Mutation_p.P907H	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1100					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TGTATCACTGGGTAAACTGGA	0.587		NA											20	50					7.45e-12	8.49e-12	1	0
PRMT7	54496	broad.mit.edu	37	16	68390961	68390961	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:68390961G>A	uc002evy.1	+	19	2189	c.1913G>A	c.(1912-1914)GGC>GAC	p.G638D	PRMT7_uc010vlg.1_Missense_Mutation_p.G588D|PRMT7_uc002evz.1_Missense_Mutation_p.G410D	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	638					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CTACAGGGGGGCTGCTGCTGG	0.632		NA											4	28					0	0	0	0
TUSC5	286753	broad.mit.edu	37	17	1183494	1183494	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:1183494G>A	uc002fsi.1	+	1	538	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	67					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCCATCTCCGAGGGGCACCT	0.632		NA											17	54					0	0	0	0
MYO1C	4641	broad.mit.edu	37	17	1387576	1387576	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:1387576G>A	uc002fsp.2	-	2	317	c.97C>T	c.(97-99)CGG>TGG	p.R33W	MYO1C_uc002fsn.2_Missense_Mutation_p.R14W|MYO1C_uc002fso.2_5'UTR|MYO1C_uc010vqj.1_5'UTR|MYO1C_uc010vqk.1_Missense_Mutation_p.R9W	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	33					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ATGGTCACCCGAACCCCGTCA	0.652		NA											6	24					0	0	0	0
WSCD1	23302	broad.mit.edu	37	17	5998441	5998441	+	Silent	SNP	C	C	T	rs148922288		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:5998441C>T	uc010cli.2	+	5	1126	c.747C>T	c.(745-747)CGC>CGT	p.R249R	WSCD1_uc002gcn.2_Silent_p.R249R|WSCD1_uc002gco.2_Silent_p.R249R|WSCD1_uc010clj.2_5'UTR	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	249	WSC 2.					integral to membrane	sulfotransferase activity				0						CCACCTACCGCGGATGCTTCC	0.572		NA											18	82					0	0	0	0
SPAG5	10615	broad.mit.edu	37	17	26913009	26913009	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:26913009C>T	uc002hbq.2	-	7	1705	c.1613G>A	c.(1612-1614)CGT>CAT	p.R538H	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	538					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					TGTTTCTGCACGCCGAGACTA	0.483		NA											46	143					0	0	0	0
MED24	9862	broad.mit.edu	37	17	38175892	38175892	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:38175892C>T	uc002htt.2	-	26	3173	c.2860G>A	c.(2860-2862)GAA>AAA	p.E954K	MED24_uc010weq.1_Missense_Mutation_p.E76K|MED24_uc002htr.2_Missense_Mutation_p.E66K|MED24_uc010wer.1_Missense_Mutation_p.E332K|MED24_uc010wes.1_Missense_Mutation_p.E814K|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.E979K|MED24_uc002htu.2_Missense_Mutation_p.E941K|MED24_uc010cwn.2_Missense_Mutation_p.E941K|MED24_uc010weu.1_Missense_Mutation_p.E864K	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	954					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TTCACCAGTTCCGACACCTGC	0.657		NA											20	42					0	0	0	0
VEZF1	7716	broad.mit.edu	37	17	56060414	56060414	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:56060414C>T	uc002ivf.1	-	2	517	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	VEZF1_uc010dcn.1_5'UTR	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	125					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CAACGAAGTTCGGCTGCTGTC	0.567		NA											10	36					0	0	0	0
ANKRD12	23253	broad.mit.edu	37	18	9257777	9257777	+	Silent	SNP	G	G	T	rs74916798		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr18:9257777G>T	uc002knv.2	+	9	4769	c.4512G>T	c.(4510-4512)TCG>TCT	p.S1504S	ANKRD12_uc002knw.2_Silent_p.S1481S|ANKRD12_uc002knx.2_Silent_p.S1481S|ANKRD12_uc010dkx.1_Silent_p.S1211S	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1504						nucleus				ovary(2)|central_nervous_system(1)	3						ATGCTGAATCGATTTCTAAAC	0.413		NA											11	35					7.04e-09	7.87e-09	1	0
KCTD1	284252	broad.mit.edu	37	18	24039710	24039710	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr18:24039710C>G	uc002kvw.2	-	4	1049	c.489G>C	c.(487-489)TTG>TTC	p.L163F	KCTD1_uc010xbj.1_Missense_Mutation_p.L771F|KCTD1_uc010xbk.1_Missense_Mutation_p.L163F|KCTD1_uc002kvy.2_Missense_Mutation_p.L81F	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	163					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CTTCTTCTATCAAGGATTTGT	0.512		NA											4	63					0	0	0	0
S1PR4	8698	broad.mit.edu	37	19	3179595	3179595	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:3179595G>A	uc002lxg.2	+	1	830	c.805G>A	c.(805-807)GGG>AGG	p.G269R		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	269	Helical; Name=6; (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CCCACTCTTCGGGCTGCTGCT	0.697		NA											31	56					0	0	0	0
ZNF763	284390	broad.mit.edu	37	19	12089308	12089308	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:12089308G>A	uc002msw.2	+	4	724	c.569G>A	c.(568-570)CGC>CAC	p.R190H	ZNF763_uc010xmf.1_Missense_Mutation_p.R210H|ZNF763_uc002msv.2_Missense_Mutation_p.R193H|ZNF763_uc010xmg.1_Missense_Mutation_p.R68H	NM_001012753	NP_001012771	Q0D2J5	ZN763_HUMAN	zinc finger protein 763	190	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ATTCGAAGACGCATGGTAATG	0.408		NA											40	94					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17768990	17768990	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:17768990C>T	uc002nhd.2	-	10	912	c.912G>A	c.(910-912)ACG>ACA	p.T304T		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	216					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TGGGTTGTGACGTAGTATAAT	0.557		NA											3	31					0	0	0	0
SLC7A10	56301	broad.mit.edu	37	19	33702376	33702376	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:33702376C>A	uc002num.2	-	6	1003	c.856G>T	c.(856-858)GCC>TCC	p.A286S	SLC7A10_uc002nul.2_5'UTR	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	286	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GTGAAGTAGGCAATGTTGGTG	0.627		NA											5	20					0.000602214	0.00063008	1	0
HKR1	284459	broad.mit.edu	37	19	37854366	37854366	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:37854366G>A	uc002ogb.2	+	6	1938	c.1669G>A	c.(1669-1671)GAG>AAG	p.E557K	HKR1_uc002ofx.2_Missense_Mutation_p.E273K|HKR1_uc002ofy.2_Missense_Mutation_p.E273K|HKR1_uc002oga.2_Missense_Mutation_p.E539K|HKR1_uc010xto.1_Missense_Mutation_p.E539K|HKR1_uc002ogc.2_Missense_Mutation_p.E538K|HKR1_uc010xtp.1_Missense_Mutation_p.E496K|HKR1_uc002ogd.2_Missense_Mutation_p.E496K	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	557	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTGCAGGGAGTGTGGCAG	0.512		NA											9	25					0	0	0	0
ZNF419	79744	broad.mit.edu	37	19	58004287	58004287	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:58004287G>A	uc002qov.2	+	5	602	c.362G>A	c.(361-363)AGT>AAT	p.S121N	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.S122N|ZNF419_uc010etz.1_Missense_Mutation_p.S109N|ZNF419_uc010eua.1_Missense_Mutation_p.S108N|ZNF419_uc002qow.2_Missense_Mutation_p.S89N|ZNF419_uc010eub.1_Missense_Mutation_p.S76N|ZNF419_uc010euc.1_Missense_Mutation_p.S75N	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		GGACTGCTCAGTTCAAACATT	0.473		NA											6	27					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33413884	33413884	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:33413884T>C	uc002ros.2	+	7	1667	c.1667T>C	c.(1666-1668)CTT>CCT	p.L556P	LTBP1_uc002rot.2_Missense_Mutation_p.L230P|LTBP1_uc002rou.2_Missense_Mutation_p.L230P|LTBP1_uc002rov.2_Missense_Mutation_p.L230P|LTBP1_uc010ymz.1_Missense_Mutation_p.L230P|LTBP1_uc010yna.1_Missense_Mutation_p.L230P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	556					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGACACAGCTTGGCCGGTGC	0.498		NA											36	80					0	0	0	0
GPR75	10936	broad.mit.edu	37	2	54080512	54080512	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:54080512G>A	uc002rxo.3	-	2	1653	c.1382C>T	c.(1381-1383)TCT>TTT	p.S461F	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	461	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATGTCCAGCAGAGATCTTGGG	0.488		NA											16	134					0	0	0	0
COX5B	1329	broad.mit.edu	37	2	98264531	98264531	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:98264531G>A	uc002sya.2	+	4	379	c.350G>A	c.(349-351)GGA>GAA	p.G117E		NM_001862	NP_001853	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb precursor	117					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding				0						CCCCGCTGTGGAGCCCATTAC	0.502		NA											3	30					0	0	0	0
GRB14	2888	broad.mit.edu	37	2	165365311	165365311	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:165365311C>T	uc002ucl.2	-	7	1409	c.868G>A	c.(868-870)GTG>ATG	p.V290M	GRB14_uc010zcv.1_Missense_Mutation_p.V203M|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	290	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GCCAGTGACACATAAATATCA	0.348		NA											16	63					0	0	0	0
CIR1	9541	broad.mit.edu	37	2	175252492	175252492	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:175252492G>A	uc002uim.2	-	2	181	c.88C>T	c.(88-90)CAG>TAG	p.Q30*	CIR1_uc002uin.2_5'UTR|CIR1_uc002uio.2_5'UTR|CIR1_uc002uip.2_5'UTR	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	30	Interaction with RBPJ.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						GATATTTTCTGTTCTGCCATC	0.254		NA											11	42					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443		NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			3	46					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098957	178098957	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:178098957G>A	uc002ulh.3	-	2	643	c.88C>T	c.(88-90)CTT>TTT	p.L30F	NFE2L2_uc002ulg.3_Missense_Mutation_p.L14F|NFE2L2_uc010zfa.1_Missense_Mutation_p.L14F|NFE2L2_uc002uli.3_Missense_Mutation_p.L14F|NFE2L2_uc010fra.2_Missense_Mutation_p.L14F|NFE2L2_uc010frb.2_Missense_Mutation_p.L14F	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	30					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CTTACTCCAAGATCTATATCT	0.368		NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			7	25					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179584490	179584490	+	Missense_Mutation	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:179584490C>A	uc010zfg.1	-	79	20221	c.19997G>T	c.(19996-19998)TGT>TTT	p.C6666F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.C3327F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7593							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCACTACACACTCTAATGC	0.398		NA											4	54					0.00024832	0.00026251	1	0
MPP4	58538	broad.mit.edu	37	2	202523236	202523236	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:202523236C>T	uc002uyk.3	-	16	1301	c.1093G>A	c.(1093-1095)GAG>AAG	p.E365K	MPP4_uc002uyi.3_5'UTR|MPP4_uc010ftj.2_Missense_Mutation_p.E358K|MPP4_uc010zhq.1_Missense_Mutation_p.E334K|MPP4_uc010zhr.1_Missense_Mutation_p.E341K|MPP4_uc010zhs.1_Missense_Mutation_p.E290K|MPP4_uc002uyj.3_Missense_Mutation_p.E330K|MPP4_uc010zht.1_Missense_Mutation_p.E307K|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.E321K	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	365						cytoplasm	protein binding				0						ACAAACTCCTCCTTGTCTGAA	0.368		NA											8	15					0	0	0	0
ACCN4	55515	broad.mit.edu	37	2	220397137	220397137	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:220397137G>A	uc002vma.2	+	4	1351	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q	ACCN4_uc010fwi.1_Missense_Mutation_p.R446Q|ACCN4_uc010fwj.1_Missense_Mutation_p.R446Q|ACCN4_uc002vly.1_3'UTR|ACCN4_uc002vlz.2_Missense_Mutation_p.R446Q|ACCN4_uc002vmb.2_Missense_Mutation_p.R100Q	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	446	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		TCTGCCTGCCGGCTGCGCTGT	0.677		NA											15	24					0	0	0	0
RBM44	375316	broad.mit.edu	37	2	238726938	238726938	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:238726938G>A	uc002vxi.3	+	3	1511	c.1379G>A	c.(1378-1380)AGT>AAT	p.S460N		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	459							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GATGCAGCAAGTTGTACAGTC	0.398		NA											15	28					0	0	0	0
SLC5A4	6527	broad.mit.edu	37	22	32625325	32625325	+	Missense_Mutation	SNP	C	C	T	rs142416109		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:32625325C>T	uc003ami.2	-	11	1138	c.1136G>A	c.(1135-1137)CGA>CAA	p.R379Q		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	379	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CATCAGGCCTCGCAGTCCTGG	0.537		NA											5	36					0	0	0	0
APOL2	23780	broad.mit.edu	37	22	36623928	36623928	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:36623928G>A	uc003aoz.2	-	5	872	c.536C>T	c.(535-537)GCC>GTC	p.A179V	APOL2_uc011amm.1_Missense_Mutation_p.A291V|APOL2_uc003apa.2_Missense_Mutation_p.A179V	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	179					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						GCGGGCTTGGGCTCGTGCCCG	0.517		NA											16	37					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41564866	41564866	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:41564866C>G	uc003azl.3	+	25	4562	c.4167C>G	c.(4165-4167)AAC>AAG	p.N1389K		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1389					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCCACCCAACCAGAGGTATG	0.458		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				5	80					0	0	0	0
MTMR14	64419	broad.mit.edu	37	3	9691417	9691417	+	Silent	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:9691417C>A	uc003brz.2	+	1	274	c.150C>A	c.(148-150)GGC>GGA	p.G50G	MTMR14_uc003bsa.2_Silent_p.G50G|MTMR14_uc003bsb.2_Silent_p.G50G|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Silent_p.G50G	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	50						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					GCGGGACCGGCGGCTCTAAGG	0.612		NA											7	13					5.18e-06	5.62e-06	1	0
PLCL2	23228	broad.mit.edu	37	3	17056295	17056295	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:17056295C>T	uc011awc.1	+	6	2991	c.2886C>T	c.(2884-2886)CCC>CCT	p.P962P	PLCL2_uc011awd.1_Silent_p.P844P	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	970					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TTCTGGGGCCCGATAACACAC	0.542		NA											43	115					0	0	0	0
TBC1D5	9779	broad.mit.edu	37	3	17226630	17226630	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:17226630T>C	uc003cbf.2	-	19	3488	c.1823A>G	c.(1822-1824)TAC>TGC	p.Y608C	TBC1D5_uc010heu.2_Missense_Mutation_p.Y195C|TBC1D5_uc010hev.2_Missense_Mutation_p.Y630C|TBC1D5_uc003cbe.2_Missense_Mutation_p.Y608C|TBC1D5_uc010hew.1_Missense_Mutation_p.Y582C	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	608						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CTTTGCACAGTATTTGCACAT	0.383		NA											18	50					0	0	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28557085	28557085	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:28557085G>A	uc003ceh.2	+	8	925	c.757G>A	c.(757-759)GAT>AAT	p.D253N	ZCWPW2_uc003cei.2_Missense_Mutation_p.D253N|ZCWPW2_uc010hfo.2_Missense_Mutation_p.D58N	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	253							zinc ion binding			ovary(2)	2						TGTTTATTCTGATGATGCCTT	0.308		NA											7	20					0	0	0	0
SETD2	29072	broad.mit.edu	37	3	47147603	47147603	+	Missense_Mutation	SNP	A	A	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:47147603A>T	uc003cqs.2	-	6	4776	c.4723T>A	c.(4723-4725)TTT>ATT	p.F1575I	SETD2_uc003cqv.2_Missense_Mutation_p.F1564I	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1575	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCTAGGACAAAGGTGTTCCTG	0.363		NA	N|F|S|Mis		clear cell renal carcinoma								10	26					0	0	0	0
PLXNB1	5364	broad.mit.edu	37	3	48460693	48460693	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:48460693C>G	uc003csw.2	-	12	3062	c.2792G>C	c.(2791-2793)CGG>CCG	p.R931P	PLXNB1_uc003csu.2_Missense_Mutation_p.R748P|PLXNB1_uc003csx.2_Missense_Mutation_p.R931P|PLXNB1_uc010hjx.1_RNA|PLXNB1_uc003csy.1_5'Flank	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	931	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCGGATTTCCCGCTCCACATG	0.612		NA											9	12					0	0	0	0
CADM2	253559	broad.mit.edu	37	3	85932554	85932554	+	Missense_Mutation	SNP	A	A	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:85932554A>T	uc003dqj.2	+	3	951	c.325A>T	c.(325-327)ATG>TTG	p.M109L	CADM2_uc003dqk.2_Missense_Mutation_p.M118L|CADM2_uc003dql.2_Missense_Mutation_p.M111L	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	109	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TTTATTTACAATGCCTGTCAA	0.428		NA											13	22					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89468369	89468369	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:89468369G>T	uc003dqy.2	+	11	2128	c.1903G>T	c.(1903-1905)GTG>TTG	p.V635L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	635	Cytoplasmic (Potential).|Protein kinase.|ATP (By similarity).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATTTGGAGAGGTGTGCAGTGG	0.363		NA								TSP Lung(6;0.00050)			25	41					7.93e-12	9.01e-12	1	0
FAM55C	91775	broad.mit.edu	37	3	101520161	101520161	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:101520161G>A	uc003dvn.2	+	5	813	c.176G>A	c.(175-177)CGA>CAA	p.R59Q	FAM55C_uc010hpn.2_Missense_Mutation_p.R59Q	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	59						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GGAATTAGCCGAAATCCCTAC	0.532		NA											6	127					0	0	0	0
ADCY5	111	broad.mit.edu	37	3	123046600	123046600	+	Missense_Mutation	SNP	G	G	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:123046600G>C	uc003egh.1	-	7	1812	c.1812C>G	c.(1810-1812)ATC>ATG	p.I604M	ADCY5_uc003egg.1_Missense_Mutation_p.I237M|ADCY5_uc003egi.1_Missense_Mutation_p.I163M	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	604	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGGTGATGTGGATGCGTCTAC	0.552		NA											3	25					0	0	0	0
GHSR	2693	broad.mit.edu	37	3	172165820	172165820	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:172165820G>A	uc003fib.1	-	1	384	c.384C>T	c.(382-384)TAC>TAT	p.Y128Y	GHSR_uc011bpv.1_Silent_p.Y128Y	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	128	Helical; Name=3; (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCACCGTGGCGTAGGTGCAGC	0.632		NA											8	19					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	61					0	0	0	0
RGS12	6002	broad.mit.edu	37	4	3318626	3318626	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:3318626G>A	uc003ggw.2	+	2	1633	c.729G>A	c.(727-729)ACG>ACA	p.T243T	RGS12_uc003ggu.2_Silent_p.T243T|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.T243T|RGS12_uc003ggx.1_Silent_p.T243T	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	243	PID.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTCCTTCCACGAGCTCCAACC	0.532		NA											13	46					0	0	0	0
CLOCK	9575	broad.mit.edu	37	4	56315585	56315585	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:56315585C>G	uc003haz.1	-	18	2353	c.1427G>C	c.(1426-1428)AGA>ACA	p.R476T	CLOCK_uc003hba.1_Missense_Mutation_p.R476T|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	476					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TGATGACCTTCTTTGCACCAT	0.398		NA											23	48					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126412412	126412412	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:126412412G>T	uc003ifj.3	+	17	14435	c.14435G>T	c.(14434-14436)AGG>ATG	p.R4812M	FAT4_uc011cgp.1_Missense_Mutation_p.R3053M|FAT4_uc003ifi.1_Missense_Mutation_p.R2289M	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4812	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GACCATGGGAGGTCTTCTTCA	0.512		NA											21	45					2.39e-15	2.74e-15	1	0
TMEM184C	55751	broad.mit.edu	37	4	148554974	148554974	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:148554974C>T	uc003ila.3	+	9	1507	c.938C>T	c.(937-939)TCA>TTA	p.S313L		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	313						integral to membrane					0						TACACATTCTCATATAAACCA	0.368		NA											4	83					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187525008	187525008	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:187525008C>A	uc003izf.2	-	19	10860	c.10672G>T	c.(10672-10674)GAA>TAA	p.E3558*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3558	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTGAGTATTCTTCTCCAGAA	0.473		NA								HNSCC(5;0.00058)			7	28					8.13e-05	8.64e-05	1	0
FAT1	2195	broad.mit.edu	37	4	187539863	187539863	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:187539863C>T	uc003izf.2	-	10	8065	c.7877G>A	c.(7876-7878)GGC>GAC	p.G2626D		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2626	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGCATTGGAGCCCTCATCGGC	0.448		NA								HNSCC(5;0.00058)			9	27					0	0	0	0
SPEF2	79925	broad.mit.edu	37	5	35659168	35659168	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:35659168C>T	uc003jjo.2	+	8	1137	c.1026C>T	c.(1024-1026)TCC>TCT	p.S342S	SPEF2_uc003jjn.1_Silent_p.S342S|SPEF2_uc003jjq.3_Silent_p.S342S	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	342	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCGGCAGTCCCAGCAGGAGC	0.468		NA											11	18					0	0	0	0
MEF2C	4208	broad.mit.edu	37	5	88027717	88027717	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:88027717C>T	uc003kjj.2	-	7	1312	c.639G>A	c.(637-639)GGG>GGA	p.G213G	MEF2C_uc003kji.2_Silent_p.G213G|MEF2C_uc003kjk.2_Silent_p.G213G|MEF2C_uc003kjm.2_Silent_p.G211G|MEF2C_uc003kjl.2_Silent_p.G231G	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	213					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CATACCCGTTCCCTGTTAACA	0.388		NA								HNSCC(66;0.2)			6	11					0	0	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230437	140230437	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:140230437C>T	uc003lhu.2	+	1	3081	c.2357C>T	c.(2356-2358)ACG>ATG	p.T786M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.T786M	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	786	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGAGCGAACGGGAGAACCC	0.463		NA											17	53					0	0	0	0
PCDHA12	56137	broad.mit.edu	37	5	140257232	140257232	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:140257232G>A	uc003lic.2	+	1	2302	c.2175G>A	c.(2173-2175)GCG>GCA	p.A725A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A725A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGCTCAGCGCCGCCCACCG	0.647		NA											4	26					0	0	0	0
KCNIP1	30820	broad.mit.edu	37	5	170148874	170148874	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:170148874C>T	uc003mas.2	+	5	856	c.327C>T	c.(325-327)TTC>TTT	p.F109F	KCNIP1_uc003map.2_Silent_p.F107F|KCNIP1_uc003mat.2_Silent_p.F98F|KCNIP1_uc010jjp.2_Silent_p.F70F|KCNIP1_uc010jjq.2_Silent_p.F123F	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	109	EF-hand 2.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAATGCCTTCGACACCACTC	0.547		NA											51	96					0	0	0	0
BMP6	654	broad.mit.edu	37	6	7727808	7727808	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:7727808C>T	uc003mxu.3	+	1	798	c.620C>T	c.(619-621)GCC>GTC	p.A207V		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	207					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CAGGACAGCGCCTTCCTCAAC	0.647		NA											5	14					0	0	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056394	26056394	+	Missense_Mutation	SNP	A	A	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:26056394A>C	uc003nfw.2	-	1	306	c.263T>G	c.(262-264)GTG>GGG	p.V88G		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	88	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCCCTTGCTCACCAGGCTCTT	0.532		NA											14	94					0	0	0	0
FKBPL	63943	broad.mit.edu	37	6	32097032	32097032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:32097032G>A	uc003nzr.2	-	2	796	c.526C>T	c.(526-528)CAG>TAG	p.Q176*	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	176					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						CCAGGCAGCTGAAGCTCTGCT	0.572		NA											10	149					0	0	0	0
HACE1	57531	broad.mit.edu	37	6	105233004	105233004	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:105233004C>T	uc003pqu.1	-	12	1542	c.1265G>A	c.(1264-1266)GGC>GAC	p.G422D	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.G422D|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.G75D	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	422					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TTCCCTTGTGCCAGTGGACAG	0.458		NA											3	46					0	0	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378489	114378489	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:114378489G>A	uc003pwg.3	-	2	1005	c.973C>T	c.(973-975)CGC>TGC	p.R325C	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.R325C	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	325	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		AAGAATTTGCGCAATTTAGTA	0.408		NA											23	44					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129649434	129649434	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:129649434G>A	uc003qbn.2	+	29	4293	c.4188G>A	c.(4186-4188)CCG>CCA	p.P1396P	LAMA2_uc003qbo.2_Silent_p.P1396P	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1396	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CATGCTTGCCGGGATTTTATC	0.507		NA											21	73					0	0	0	0
TCF21	6943	broad.mit.edu	37	6	134210907	134210907	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:134210907G>A	uc003qei.3	+	1	648	c.372G>A	c.(370-372)GCG>GCA	p.A124A	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.A124A	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	124	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		TCAGGCTGGCGTCCAGCTACA	0.617		NA											32	94					0	0	0	0
AIG1	51390	broad.mit.edu	37	6	143605338	143605338	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:143605338C>T	uc003qjh.2	+	4	531	c.491C>T	c.(490-492)ACC>ATC	p.T164I	AIG1_uc003qjf.2_Missense_Mutation_p.T154I|AIG1_uc003qji.2_Missense_Mutation_p.T102I	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	164						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		GCCATATGTACCTTCTCTGTT	0.433		NA											4	31					0	0	0	0
SUN1	23353	broad.mit.edu	37	7	883126	883126	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:883126G>A	uc011jvp.1	+	6	706	c.627G>A	c.(625-627)TCG>TCA	p.S209S	SUN1_uc010ksa.1_Silent_p.S230S|SUN1_uc003sje.1_Silent_p.S209S|SUN1_uc003sjf.2_Silent_p.S159S|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Silent_p.S20S	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	209	SYNE2-binding.|Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGCCCGTGTCGAGAGTTTATT	0.522		NA											47	144					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6426860	6426860	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:6426860G>A	uc003spx.2	+	2	294	c.53G>A	c.(52-54)TGC>TAC	p.C18Y	RAC1_uc003spw.2_Missense_Mutation_p.C18Y	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	18					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GGTAAAACTTGCCTACTGATC	0.338		NA											17	41					0	0	0	0
DFNA5	1687	broad.mit.edu	37	7	24756873	24756873	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:24756873C>T	uc010kus.1	-	5	785	c.697G>A	c.(697-699)GAG>AAG	p.E233K	DFNA5_uc003swz.2_Missense_Mutation_p.E69K|DFNA5_uc003sxa.1_Missense_Mutation_p.E233K|DFNA5_uc010kut.1_Missense_Mutation_p.E69K|DFNA5_uc003sxb.2_Missense_Mutation_p.G233S	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	233					sensory perception of sound					ovary(1)	1						TGGCACTCACCGAACTGGCCG	0.562		NA											10	35					0	0	0	0
PKD1L1	168507	broad.mit.edu	37	7	47944031	47944031	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:47944031G>T	uc003tny.1	-	12	1875	c.1875C>A	c.(1873-1875)GAC>GAA	p.D625E		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	625	Extracellular (Potential).|PKD 2.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CATCCCCAAAGTCCCACAGGT	0.602		NA											13	25					2.27e-07	2.5e-07	1	0
ZNF479	90827	broad.mit.edu	37	7	57188354	57188354	+	Silent	SNP	A	A	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:57188354A>G	uc010kzo.2	-	5	1039	c.768T>C	c.(766-768)CTT>CTC	p.L256L		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	256	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TATGTCTAGTAAGGTTTGCAG	0.428		NA											6	32					0	0	0	0
HIP1	3092	broad.mit.edu	37	7	75192259	75192259	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:75192259C>T	uc003uds.1	-	11	1041	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	HIP1_uc011kfz.1_Missense_Mutation_p.D211N	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	334					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GCATCCATGTCCATGAGGTCA	0.592		NA	T	PDGFRB	CMML								4	27					0	0	0	0
PLXNA4	91584	broad.mit.edu	37	7	131849918	131849918	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:131849918G>A	uc003vra.3	-	23	4557	c.4328C>T	c.(4327-4329)ACT>ATT	p.T1443I		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1443	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GAGGAGGAAAGTAAACCAATT	0.517		NA											19	47					0	0	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389491	150389491	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:150389491G>A	uc003who.2	+	3	205	c.117G>A	c.(115-117)GGG>GGA	p.G39G	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	39						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCTGCAGGGAACAGCATCC	0.512		NA											7	23					0	0	0	0
DLGAP2	9228	broad.mit.edu	37	8	1626408	1626408	+	Missense_Mutation	SNP	G	G	A	rs34274599		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:1626408G>A	uc003wpl.2	+	9	2174	c.2077G>A	c.(2077-2079)GTC>ATC	p.V693I	DLGAP2_uc003wpm.2_Missense_Mutation_p.V679I	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	772					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TTCTAACAGCGTCACGGCCGC	0.557		NA											18	36					0	0	0	0
CHD7	55636	broad.mit.edu	37	8	61765577	61765577	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:61765577G>A	uc003xue.2	+	31	6770	c.6293G>A	c.(6292-6294)CGA>CAA	p.R2098Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2098					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CGGCATGACCGAGACTTGCTG	0.542		NA											13	26					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73480224	73480224	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:73480224C>T	uc003xzb.2	+	2	843	c.255C>T	c.(253-255)AAC>AAT	p.N85N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	85	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TGAACGAGAACGAGTATTTCT	0.512		NA											17	47					0	0	0	0
RAD54B	25788	broad.mit.edu	37	8	95419835	95419835	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:95419835C>T	uc003ygk.2	-	5	711	c.613G>A	c.(613-615)GGC>AGC	p.G205S	RAD54B_uc010may.1_Missense_Mutation_p.G12S|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			AAACACCTGCCACTGCTGAAG	0.418		NA						Direct_reversal_of_damage|Homologous_recombination					5	44					0	0	0	0
PGCP	10404	broad.mit.edu	37	8	97892096	97892096	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:97892096G>A	uc003yhw.2	+	4	878	c.712G>A	c.(712-714)GAT>AAT	p.D238N	PGCP_uc010mbe.2_Missense_Mutation_p.D238N	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	238					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TACGGTGGAAGATGCAGAAAT	0.463		NA											5	134					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110412468	110412468	+	Silent	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:110412468T>C	uc003yne.2	+	13	1280	c.1176T>C	c.(1174-1176)TTT>TTC	p.F392F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	392	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGCACGCTTTAGTGGATTTT	0.418		NA								HNSCC(38;0.096)			23	228					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535536	110535536	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:110535536C>T	uc003yne.2	+	76	12509	c.12405C>T	c.(12403-12405)GTC>GTT	p.V4135V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4135	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATAACCAAGTCAATGGCCTTA	0.398		NA								HNSCC(38;0.096)			18	48					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113353856	113353856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:113353856G>A	uc003ynu.2	-	42	6661	c.6502C>T	c.(6502-6504)CGA>TGA	p.R2168*	CSMD3_uc003yns.2_Nonsense_Mutation_p.R1370*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.R2128*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.R2064*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2168	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATCCACTTCGTACTTCCAAA	0.368		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	18					0	0	0	0
EIF3H	8667	broad.mit.edu	37	8	117658786	117658786	+	Silent	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:117658786C>A	uc003yoa.2	-	7	911	c.885G>T	c.(883-885)CCG>CCT	p.P295P	EIF3H_uc003yob.2_Silent_p.P309P	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	295					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					CCTCAGGGAGCGGGGGTTCTC	0.527		NA											44	131					2.48e-24	2.87e-24	1	0
PLEC	5339	broad.mit.edu	37	8	144991068	144991068	+	Silent	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:144991068C>T	uc003zaf.1	-	32	13502	c.13332G>A	c.(13330-13332)ACG>ACA	p.T4444T	PLEC_uc003zab.1_Silent_p.T4307T|PLEC_uc003zac.1_Silent_p.T4311T|PLEC_uc003zad.2_Silent_p.T4307T|PLEC_uc003zae.1_Silent_p.T4275T|PLEC_uc003zag.1_Silent_p.T4285T|PLEC_uc003zah.2_Silent_p.T4293T|PLEC_uc003zaj.2_Silent_p.T4334T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4444	Globular 2.|Plectin 29.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCGCTGCCCCGTGATGTTAT	0.677		NA											3	47					0	0	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18574122	18574122	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:18574122T>C	uc003zne.3	+	4	459	c.332T>C	c.(331-333)GTG>GCG	p.V111A	ADAMTSL1_uc003znb.2_Missense_Mutation_p.V111A|ADAMTSL1_uc003znc.3_Missense_Mutation_p.V111A	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	111						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGCTTCCTGTGTCTAATGAC	0.498		NA											41	108					0	0	0	0
VCP	7415	broad.mit.edu	37	9	35059087	35059087	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:35059087C>T	uc003zvy.2	-	15	2523	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.E381K|VCP_uc010mki.1_Missense_Mutation_p.E667K	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	712					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTCTGCCTCTCTCGTTCTCGC	0.552		NA											21	54					0	0	0	0
FBXO10	26267	broad.mit.edu	37	9	37518327	37518327	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:37518327C>T	uc004aab.2	-	9	2358	c.2309G>A	c.(2308-2310)CGA>CAA	p.R770Q	FBXO10_uc004aac.2_Missense_Mutation_p.R786Q|FBXO10_uc004aad.2_Missense_Mutation_p.R320Q	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	770	PbH1 15.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GTTGGCCACTCGGGTGGGTTG	0.567		NA											14	26					0	0	0	0
DCAF10	79269	broad.mit.edu	37	9	37854962	37854962	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:37854962G>A	uc004aao.2	+	4	1111	c.1037G>A	c.(1036-1038)AGA>AAA	p.R346K	DCAF10_uc010mlz.2_Missense_Mutation_p.R173K|DCAF10_uc004aap.2_Missense_Mutation_p.R34K	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	346						CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						AGAGCAAGAAGAACTACTTCA	0.338		NA											19	60					0	0	0	0
GDA	9615	broad.mit.edu	37	9	74838108	74838108	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:74838108G>A	uc004aiq.2	+	7	862	c.679G>A	c.(679-681)GGC>AGC	p.G227S	GDA_uc011lse.1_Missense_Mutation_p.G153S|GDA_uc011lsf.1_Missense_Mutation_p.G153S|GDA_uc004air.2_Missense_Mutation_p.G227S|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.G153S	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	227					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGGTGAACTGGGCAACATTGC	0.418		NA											15	63					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77370340	77370340	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:77370340G>A	uc004ajl.1	-	28	5073	c.4835C>T	c.(4834-4836)CCA>CTA	p.P1612L	TRPM6_uc004ajk.1_Missense_Mutation_p.P1607L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.P563L|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.P568L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1612	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTTTTCTCCTGGCTCTGGATT	0.423		NA											26	66					0	0	0	0
OR13C4	138804	broad.mit.edu	37	9	107288587	107288587	+	Missense_Mutation	SNP	C	C	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:107288587C>G	uc011lvn.1	-	1	904	c.904G>C	c.(904-906)GAT>CAT	p.D302H		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTTTTACATCTTTATTTCTC	0.378		NA											5	70					0	0	0	0
OR13C9	286362	broad.mit.edu	37	9	107380043	107380043	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:107380043G>T	uc011lvr.1	-	1	443	c.443C>A	c.(442-444)TCC>TAC	p.S148Y		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAAACCAGGACCCAACAGC	0.448		NA											14	103					9.05e-12	1.03e-11	1	0
SVEP1	79987	broad.mit.edu	37	9	113139598	113139598	+	Missense_Mutation	SNP	T	T	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:113139598T>A	uc010mtz.2	-	45	10794	c.10457A>T	c.(10456-10458)AAT>ATT	p.N3486I	SVEP1_uc010mty.2_Missense_Mutation_p.N1412I	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3486					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGAACAAGCATTTGGGCGTTG	0.502		NA											18	42					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113170974	113170974	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:113170974C>T	uc010mtz.2	-	38	7243	c.6906G>A	c.(6904-6906)TGG>TGA	p.W2302*	SVEP1_uc010mty.2_Nonsense_Mutation_p.W228*	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2302	Sushi 15.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTGACATGTCCAAGAACTGT	0.443		NA											17	59					0	0	0	0
ZNF883	169834	broad.mit.edu	37	9	115760171	115760171	+	Missense_Mutation	SNP	T	T	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:115760171T>G	uc011lwy.1	-	5	1608	c.369A>C	c.(367-369)AAA>AAC	p.K123N		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGATAGGGTTTTTCTCCAG	0.378		NA											3	45					0	0	0	0
POLA1	5422	broad.mit.edu	37	X	24722565	24722565	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:24722565G>A	uc004dbl.2	+	4	330	c.307G>A	c.(307-309)GCC>ACC	p.A103T	POLA1_uc004dbm.2_Missense_Mutation_p.A109T|POLA1_uc004dbn.2_5'UTR	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	103	Asp-rich.				cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	TGAAGATGATGCCCTTGATGC	0.368		NA											8	216					0	0	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254629	30254629	+	Missense_Mutation	SNP	G	G	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:30254629G>T	uc004dca.1	+	5	1325	c.588G>T	c.(586-588)AGG>AGT	p.R196S		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	196	MAGE.										0						CTCGTGGGAGGGGATTTCCCA	0.468		NA											12	35					6.4e-05	6.84e-05	1	0
FAM47A	158724	broad.mit.edu	37	X	34149053	34149053	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:34149053C>T	uc004ddg.2	-	1	1376	c.1343G>A	c.(1342-1344)CGG>CAG	p.R448Q		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	448										ovary(4)|central_nervous_system(1)	5						TTTCTTCACCCGGGCCTCACA	0.562		NA											7	59					0	0	0	0
USP9X	8239	broad.mit.edu	37	X	41075168	41075168	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:41075168G>A	uc004dfb.2	+	35	5981	c.5348G>A	c.(5347-5349)CGC>CAC	p.R1783H	USP9X_uc004dfc.2_Missense_Mutation_p.R1783H	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1783					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACCGTAAAGCGCTTGCTGATT	0.318		NA											4	46					0	0	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49127007	49127007	+	Silent	SNP	T	T	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:49127007T>A	uc004dnh.1	+	1	691	c.675T>A	c.(673-675)GGT>GGA	p.G225G	PPP1R3F_uc011mnd.1_Intron|PPP1R3F_uc004dni.2_Intron	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	225	CBM21.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					TCGGCCTGGGTCCCGGCCAGG	0.751		NA											7	13					0	0	0	0
IQSEC2	23096	broad.mit.edu	37	X	53279948	53279948	+	Missense_Mutation	SNP	C	C	T			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:53279948C>T	uc004dsd.2	-	5	2011	c.1810G>A	c.(1810-1812)GTG>ATG	p.V604M	IQSEC2_uc004dsc.2_Missense_Mutation_p.V399M	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	594	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CTCAGGTCCACGGAGCTGTCA	0.657		NA											7	11					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53577938	53577938	+	Silent	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:53577938C>A	uc004dsp.2	-	65	9711	c.9309G>T	c.(9307-9309)CGG>CGT	p.R3103R	HUWE1_uc004dsn.2_Silent_p.R1911R	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3103					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCTGTCGCTGCCGGGCTTCTT	0.582		NA											12	41					1.09e-07	1.21e-07	1	0
ARL13A	392509	broad.mit.edu	37	X	100240718	100240718	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:100240718T>C	uc004ego.2	+	4	309	c.193T>C	c.(193-195)TAT>CAT	p.Y65H	ARL13A_uc011mrf.1_Missense_Mutation_p.Y65H|ARL13A_uc010nng.2_Missense_Mutation_p.Y65H	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	65							GTP binding			ovary(1)	1						GTTAGATGAGTATGAACTTTC	0.463		NA											3	47					0	0	0	0
NKAP	79576	broad.mit.edu	37	X	119059238	119059238	+	Missense_Mutation	SNP	A	A	G			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:119059238A>G	uc004esh.2	-	9	1360	c.1193T>C	c.(1192-1194)CTG>CCG	p.L398P	NKAP_uc004esg.2_Missense_Mutation_p.L285P	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	398	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						AAAACTGGCCAGAATCTTGTT	0.398		NA											29	82					0	0	0	0
STAG2	10735	broad.mit.edu	37	X	123196817	123196817	+	Silent	SNP	C	C	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:123196817C>A	uc004etz.3	+	17	2043	c.1704C>A	c.(1702-1704)GCC>GCA	p.A568A	STAG2_uc004eua.2_Silent_p.A568A|STAG2_uc004eub.2_Silent_p.A568A|STAG2_uc004euc.2_Silent_p.A568A|STAG2_uc004eud.2_Silent_p.A568A|STAG2_uc004eue.2_Silent_p.A568A	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	568					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AGCTTTTTGCCGTGGCCCTTC	0.358		NA											16	44					1.68e-08	1.87e-08	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130217855	130217855	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:130217855G>A	uc004evz.2	+	4	812	c.467G>A	c.(466-468)CGA>CAA	p.R156Q	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R144Q|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R125Q|ARHGAP36_uc004ewc.2_Missense_Mutation_p.R20Q	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	156	Arg-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						AACGTGGTGCGAAGGGTGTTT	0.617		NA											27	53					0	0	0	0
MMGT1	93380	broad.mit.edu	37	X	135047295	135047295	+	Missense_Mutation	SNP	T	T	C			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:135047295T>C	uc004ezi.1	-	4	584	c.284A>G	c.(283-285)CAT>CGT	p.H95R	MMGT1_uc011mvw.1_Missense_Mutation_p.H160R	NM_173470	NP_775741	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1 precursor	95	Cytoplasmic (Potential).					early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0						TCGACCACGATGATTAAATAC	0.353		NA											42	100					0	0	0	0
MAP7D3	79649	broad.mit.edu	37	X	135313731	135313731	+	Missense_Mutation	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:135313731G>A	uc004ezt.2	-	8	1476	c.1385C>T	c.(1384-1386)CCC>CTC	p.P462L	MAP7D3_uc004ezs.2_Missense_Mutation_p.P426L|MAP7D3_uc011mwc.1_Missense_Mutation_p.P444L|MAP7D3_uc010nsa.1_Missense_Mutation_p.P420L	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	462						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TTTTGCCTTGGGAGATGCTTC	0.448		NA											34	90					0	0	0	0
FGF13	2258	broad.mit.edu	37	X	137715119	137715119	+	Silent	SNP	G	G	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:137715119G>A	uc004fam.2	-	5	1292	c.630C>T	c.(628-630)CAC>CAT	p.H210H	FGF13_uc004fan.2_Silent_p.H157H|FGF13_uc011mwi.1_Silent_p.H191H|FGF13_uc004faq.2_Silent_p.H220H|FGF13_uc004far.2_Silent_p.H191H|FGF13_uc011mwj.1_Silent_p.H220H|FGF13_uc011mwk.1_Silent_p.H164H	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	210					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCGTGAGATCGTGCAGTGATG	0.463		NA											7	72					0	0	0	0
KRT5	3852	broad.mit.edu	37	12	52913978	52913979	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:52913978_52913979insGG	uc001san.2	-	1	265_266	c.102_103insCC	c.(100-105)TCCGTGfs	p.S34fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.S34fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	34_35	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACCGGGACACGGAGGTGAAGC	0.663		NA											31	51	---	---	---	---	NA	NA	NA	NA
CTCF	10664	broad.mit.edu	37	16	67663349	67663361	+	Frame_Shift_Del	DEL	GAGGGGGAAAATG	GAGGGGGAAAATG	-			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:67663349_67663361delGAGGGGGAAAATG	uc002etl.2	+	10	2040_2052	c.1750_1762delGAGGGGGAAAATG	c.(1750-1764)GAGGGGGAAAATGGAfs	p.E584fs	CTCF_uc010cek.2_Frame_Shift_Del_p.E256fs|CTCF_uc002etm.1_Frame_Shift_Del_p.E73fs	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	584_588					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGATGGCGTAGAGGGGGAAAATGGAGGAGAAAC	0.413		NA											12	53	---	---	---	---	NA	NA	NA	NA
GPS2	2874	broad.mit.edu	37	17	7216126	7216127	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:7216126_7216127insGG	uc002gfv.1	-	10	1195_1196	c.932_933insCC	c.(931-933)CCTfs	p.P311fs	GPS2_uc002gfw.1_Frame_Shift_Ins_p.P273fs|GPS2_uc002gfx.1_Frame_Shift_Ins_p.P311fs|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Frame_Shift_Ins_p.P311fs	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	311					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				AGGGGAGCCGAGGGCCAGGTTG	0.545		NA											27	137	---	---	---	---	NA	NA	NA	NA
ZBTB32	27033	broad.mit.edu	37	19	36206144	36206148	+	Frame_Shift_Del	DEL	GATGG	GATGG	-			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:36206144_36206148delGATGG	uc002oay.2	+	2	826_830	c.616_620delGATGG	c.(616-621)GATGGGfs	p.D206fs	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	206_207					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGGGGAGCAGATGGGAAGCATGGA	0.615		NA											9	41	---	---	---	---	NA	NA	NA	NA
OXTR	5021	broad.mit.edu	37	3	8809643	8809645	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:8809643_8809645delGAA	uc003brc.2	-	3	851_853	c.229_231delTTC	c.(229-231)TTCdel	p.F77del		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	77	Helical; Name=2; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGTGCTTCATGAAGAAGAAGAGG	0.635		NA											5	8	---	---	---	---	NA	NA	NA	NA
TIGD4	201798	broad.mit.edu	37	4	153691769	153691770	+	Frame_Shift_Ins	INS	-	-	A			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:153691769_153691770insA	uc003imy.2	-	2	1169_1170	c.387_388insT	c.(385-390)AGTAATfs	p.S129fs		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	129_130	HTH CENPB-type.|H-T-H motif (By similarity).				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AGCCAACCATTACTGCACTTAA	0.416		NA											17	47	---	---	---	---	NA	NA	NA	NA
JMY	133746	broad.mit.edu	37	5	78611869	78611869	+	Frame_Shift_Del	DEL	T	T	-			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:78611869delT	uc003kfx.3	+	10	3226	c.2706delT	c.(2704-2706)AGTfs	p.S902fs		NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	902					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		AGCGTGGTAGTTTTCATCTGA	0.393		NA											23	81	---	---	---	---	NA	NA	NA	NA
C6orf62	81688	broad.mit.edu	37	6	24709057	24709059	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:24709057_24709059delACA	uc003nel.2	-	4	1017_1019	c.510_512delTGT	c.(508-513)GTTGTC>GTC	p.170_171VV>V		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	170_171						intracellular					0						AGGATTGTTGACAACGATTCCAG	0.384		NA											19	92	---	---	---	---	NA	NA	NA	NA
MLL3	58508	broad.mit.edu	37	7	151859299	151859300	+	Frame_Shift_Ins	INS	-	-	AAGAT			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:151859299_151859300insAAGAT	uc003wla.2	-	43	11581_11582	c.11362_11363insATCTT	c.(11362-11364)TCTfs	p.S3788fs	MLL3_uc003wkz.2_Frame_Shift_Ins_p.S2849fs|MLL3_uc003wky.2_Frame_Shift_Ins_p.S1297fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3788					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTCAAAAGAGAAGATGACTTT	0.436		NA	N		medulloblastoma								7	33	---	---	---	---	NA	NA	NA	NA
