Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VAT1L	57687	broad.mit.edu	37	16	77910292	77910292	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr16:77910292G>A	ENST00000302536.2	+	5	901	c.748G>A	c.(748-750)Gtt>Att	p.V250I	VAT1L_ENST00000563850.1_3'UTR	NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	250							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TGTGGACATCGTTTTGGATTG	0.473000													9	496					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													6	465					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	G	rs121913530		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr12:25398285C>G	ENST00000311936.3	-	2	225	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R	KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000256078.4_Missense_Mutation_p.G12R	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			24	172					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													4	73					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35391924	35391924	+	Splice_Site	SNP	C	C	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:35391924C>A	ENST00000311565.4	+	7	975	c.627_splice	c.e7+1	p.A209_splice	PPARD_ENST00000337400.2_Splice_Site_p.A209_splice|PPARD_ENST00000448077.2_Splice_Site_p.A170_splice|PPARD_ENST00000418635.2_Splice_Site_p.A111_splice|PPARD_ENST00000444397.1_Splice_Site_p.A209_splice|PPARD_ENST00000360694.3_Splice_Site_p.A209_splice|PPARD_ENST00000540939.1_Splice_Site_p.A106_splice	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	209					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	AGCCACACGGCGGTGAGTGTT	0.597000													4	137					0.00909568	0.00920396	1	1	0
WDR78	79819	broad.mit.edu	37	1	67279820	67279820	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:67279820G>A	ENST00000371026.3	-	17	2595	c.2540C>T	c.(2539-2541)tCa>tTa	p.S847L	WDR78_ENST00000431318.1_Missense_Mutation_p.S560L	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	847										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						GAATTATGCTGATTGGTTTGA	0.279000													20	187					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000509479.2_Silent_p.Q497Q|MAML3_ENST00000327122.5_Silent_p.Q341Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													5	116					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659809	24659809	+	RNA	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:24659809G>A	ENST00000414583.2	+	0	3334					NR_003714.1																						CCCTATCTGCGCACCCGGAGG	0.612000													4	13					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11022906	11022906	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:11022906C>T	ENST00000327064.4	+	5	795	c.605C>T	c.(604-606)gCc>gTc	p.A202V	CARM1_ENST00000344150.4_Missense_Mutation_p.A202V	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	202					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding	p.A202V(2)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						TCGTTTTTTGCCGCCCAAGCT	0.622000													10	1127					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33639826	33639826	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:33639826A>G	ENST00000374316.5	+	23	3809	c.2749A>G	c.(2749-2751)Atc>Gtc	p.I917V	ITPR3_ENST00000605930.1_Missense_Mutation_p.I917V			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	917					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCGGCGGTCCATCCAGGGCGT	0.637000													24	183					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													7	461					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91517846	91517846	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr15:91517846C>T	ENST00000361188.5	-	10	2530	c.1319G>A	c.(1318-1320)cGa>cAa	p.R440Q	PRC1_ENST00000394249.3_Missense_Mutation_p.R440Q|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000442656.2_Missense_Mutation_p.R399Q|PRC1_ENST00000361919.3_Missense_Mutation_p.R440Q			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	440	Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTTCTCCAATCGATGCATCTC	0.443000													15	736					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32953994	32953994	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:32953994G>A	ENST00000321639.5	+	3	974	c.646G>A	c.(646-648)Ggg>Agg	p.G216R		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	216						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCTCAAGCCCGGGGAAGTGCT	0.652000													40	272					0	0	1	0	0
LYSMD3	116068	broad.mit.edu	37	5	89814997	89814997	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr5:89814997G>A	ENST00000315948.6	-	3	704	c.560C>T	c.(559-561)tCg>tTg	p.S187L	LYSMD3_ENST00000509384.1_3'UTR|LYSMD3_ENST00000500869.2_Intron	NM_198273.1	NP_938014.1	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain containing 3	187					cell wall macromolecule catabolic process	integral to membrane				breast(2)|large_intestine(1)|lung(2)|prostate(1)|urinary_tract(1)	7		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		TGTTAAGGCCGATACTACCTC	0.413000													59	409					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189711	197189711	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:197189711T>C	ENST00000260983.2	-	6	916	c.734A>G	c.(733-735)cAc>cGc	p.H245R	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	245	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TACCTCTCGGTGCCAAATTGG	0.512000													66	518					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4016226	4016226	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr16:4016226G>A	ENST00000294016.3	-	11	4150	c.3612C>T	c.(3610-3612)tgC>tgT	p.C1204C		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1204					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCTGGATGCGGCACTCCACGC	0.602000													7	450					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813765	123813765	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:123813765G>A	ENST00000321252.2	-	1	815	c.781C>T	c.(781-783)Cgt>Tgt	p.R261C		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCTGACATACGAATGTAGAGA	0.517000													16	419					0	0	1	0	0
RAB38	23682	broad.mit.edu	37	11	87847185	87847185	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:87847185C>A	ENST00000243662.6	-	3	689	c.607G>T	c.(607-609)Gcc>Tcc	p.A203S	RP11-164N3.3_ENST00000528458.1_RNA	NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	203					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GAGCAGCTGGCAACCTTGGTT	0.483000													5	466					0.184627	0.184627	1	1	0
PCDHA4	0	broad.mit.edu	37	5	140188274	140188274	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr5:140188274A>G	ENST00000530339.1	+	1	1502	c.1502A>G	c.(1501-1503)gAg>gGg	p.E501G	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.E501G|PCDHA4_ENST00000356878.4_Missense_Mutation_p.E501G|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGTAGGGGAGCGCGCGCTG	0.662000													7	311					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56420631	56420631	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr12:56420631G>A	ENST00000262032.5	+	8	720	c.353G>A	c.(352-354)cGg>cAg	p.R118Q	IKZF4_ENST00000547791.1_Missense_Mutation_p.R73Q|IKZF4_ENST00000547167.1_Missense_Mutation_p.R118Q|IKZF4_ENST00000548601.1_3'UTR|IKZF4_ENST00000431367.2_Missense_Mutation_p.R16Q			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	118					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCAGATGAGCGGCTCCTGGAA	0.572000													7	178					0	0	1	0	0
TRBV7-1	0	broad.mit.edu	37	7	142032047	142032047	+	RNA	SNP	A	A	C	rs150998656	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr7:142032047A>C	ENST00000547918.2	+	0	42																											CCATGGGCACAAGGCTCCTCT	0.562000													4	163					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	49					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144992109	144992109	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr8:144992109G>A	ENST00000322810.4	-	32	12460	c.12291C>T	c.(12289-12291)ccC>ccT	p.P4097P	PLEC_ENST00000398774.2_Silent_p.P3928P|PLEC_ENST00000357649.2_Silent_p.P3964P|PLEC_ENST00000354958.2_Silent_p.P3938P|PLEC_ENST00000356346.3_Silent_p.P3946P|PLEC_ENST00000436759.2_Silent_p.P3987P|PLEC_ENST00000345136.3_Silent_p.P3960P|PLEC_ENST00000527096.1_Silent_p.P3983P|PLEC_ENST00000354589.3_Silent_p.P3960P	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4097	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGGCTGTGCCGGGGCGGATGA	0.627000													12	113					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96412615	96412615	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr12:96412615A>C	ENST00000228740.2	-	8	919	c.778T>G	c.(778-780)Ttg>Gtg	p.L260V	LTA4H_ENST00000413268.2_Missense_Mutation_p.L236V|LTA4H_ENST00000552789.1_Missense_Mutation_p.L236V	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	260					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						GGCAGGACCAATAGGTCATAC	0.403000													32	217					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118773097	118773097	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:118773097T>G	ENST00000334801.3	-	6	2319	c.1355A>C	c.(1354-1356)cAg>cCg	p.Q452P	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	452	Necessary for interaction with CTNNB1 (By similarity).|Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GGGTGGCTGCTGGGGGGGAGG	0.682000													7	85					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664743	22664743	+	RNA	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:22664743G>A	ENST00000426066.1	+	0	924					NR_027293.1																						CAGACTAAAGGCAAACAAGGA	0.498000													4	102					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21805150	21805150	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr7:21805150G>A	ENST00000328843.6	+	56	9097	c.9066G>A	c.(9064-9066)ccG>ccA	p.P3022P	DNAH11_ENST00000409508.3_Silent_p.P3015P			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3022	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGCGTGGCCGCAGGAGGCTC	0.532000									Kartagener syndrome				5	287					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871094	170871094	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:170871094G>A	ENST00000392092.2	+	3	549	c.270G>A	c.(268-270)caG>caA	p.Q90Q	TBP_ENST00000230354.6_Silent_p.Q90Q|TBP_ENST00000540980.1_Silent_p.Q70Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	90	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.622000													4	130					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367485.4_Silent_p.K617K|PRG4_ENST00000367483.4_Silent_p.K669K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													5	625					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29641216	29641216	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:29641216C>T	ENST00000376883.1	-	6	1023	c.612G>A	c.(610-612)atG>atA	p.M204I	ZFP57_ENST00000488757.1_Missense_Mutation_p.M224I|ZFP57_ENST00000376881.3_Missense_Mutation_p.M204I			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	140					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						CCCCAAGATGCATGCGTCTGT	0.547000													5	319					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207345998	207345998	+	Missense_Mutation	SNP	G	G	A	rs146209053	byFrequency	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:207345998G>A	ENST00000264377.3	+	3	803	c.475G>A	c.(475-477)Ggc>Agc	p.G159S	ADAM23_ENST00000374415.3_Missense_Mutation_p.G159S|ADAM23_ENST00000374416.1_Missense_Mutation_p.G159S	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	159					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGAAGCCTTCGGCTCCAAATT	0.383000													38	200					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													5	321					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321495	78321495	+	Silent	SNP	C	C	T	rs142096377		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:78321495C>T	ENST00000582970.1	+	29	9503	c.9360C>T	c.(9358-9360)taC>taT	p.Y3120Y	RNF213_ENST00000336301.6_Silent_p.Y1193Y|RNF213_ENST00000508628.2_Silent_p.Y3169Y	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACCAGTACTACGTCCACCTCG	0.547000													38	286					0	0	1	0	0
FAM27L	284123	broad.mit.edu	37	17	21826294	21826294	+	RNA	SNP	T	T	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:21826294T>A	ENST00000426869.3	+	0	477					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		CATGGTGGCCTCTCTGAACAA	0.572000													14	114					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103001403	103001403	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:103001403G>A	ENST00000409599.1	+	8	1110	c.754G>A	c.(754-756)Ggg>Agg	p.G252R	IL18R1_ENST00000233957.1_Missense_Mutation_p.G252R			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	252	Ig-like C2-type 3.				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TTGGATGTTCGGGGAAGAAAA	0.328000													5	400					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17205843	17205843	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr21:17205843G>T	ENST00000285681.2	+	17	2539	c.2170G>T	c.(2170-2172)Gag>Tag	p.E724*	USP25_ENST00000400183.2_Nonsense_Mutation_p.E724*|USP25_ENST00000351097.5_Intron|USP25_ENST00000285679.6_Nonsense_Mutation_p.E724*			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	724					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GAAATTGAGAGAGTCAGAGAC	0.333000													28	167					1.39806e-14	1.48543e-14	1	1	0
ARMC3	219681	broad.mit.edu	37	10	23297251	23297251	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:23297251C>T	ENST00000298032.5	+	15	1960	c.1876C>T	c.(1876-1878)Cga>Tga	p.R626*	ARMC3_ENST00000376528.4_Nonsense_Mutation_p.R363*|ARMC3_ENST00000409049.3_Nonsense_Mutation_p.R626*|ARMC3_ENST00000409983.3_Nonsense_Mutation_p.R626*	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	626			R -> Q (in dbSNP:rs10828395).				binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGGTTATGGACGAAGTATTTC	0.279000													8	135					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	19999089	19999089	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr13:19999089G>C	ENST00000400230.2	-	19	1508	c.1464C>G	c.(1462-1464)aaC>aaG	p.N488K	TPTE2_ENST00000390680.2_Missense_Mutation_p.N411K|TPTE2_ENST00000382978.1_Missense_Mutation_p.N448K|TPTE2_ENST00000400103.2_Missense_Mutation_p.N377K|TPTE2_ENST00000382975.4_Missense_Mutation_p.N448K|TPTE2_ENST00000457266.2_Missense_Mutation_p.N377K|TPTE2_ENST00000382977.4_Missense_Mutation_p.N488K|TPTE2_ENST00000255310.6_Missense_Mutation_p.N411K			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	488	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATTCATACCTGTTATTTTGAA	0.284000													9	84					0	0	1	0	0
SLC43A2	124935	broad.mit.edu	37	17	1489346	1489346	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:1489346C>T	ENST00000382147.4	-	10	1178	c.1090G>A	c.(1090-1092)Gtt>Att	p.V364I	SLC43A2_ENST00000412517.3_Splice_Site|SLC43A2_ENST00000571650.1_Splice_Site|SLC43A2_ENST00000301335.4_Splice_Site			Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2	360					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TAGAGGCCAACTGTGGAGGAA	0.642000													3	13					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7986996	7986996	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:7986996A>G	ENST00000221573.6	+	4	500	c.449A>G	c.(448-450)aAg>aGg	p.K150R	SNAPC2_ENST00000595035.1_3'UTR|SNAPC2_ENST00000597584.1_5'UTR	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	150					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GCCCGTGGAAAGCCTTTGCTC	0.657000													59	520					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130923012	130923012	+	Silent	SNP	G	G	A	rs144010117	byFrequency	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr12:130923012G>A	ENST00000261655.4	-	9	1666	c.1503C>T	c.(1501-1503)ccC>ccT	p.P501P	RIMBP2_ENST00000536002.1_Silent_p.P409P|RIMBP2_ENST00000535703.1_Silent_p.P409P	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	501	Fibronectin type-III 3.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGATGGTGGCGGGGGTCACCC	0.662000													11	75					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167023589	167023589	+	Silent	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:167023589C>T	ENST00000367868.3	-	7	1285	c.942G>A	c.(940-942)ccG>ccA	p.P314P	RP11-102C16.3_ENST00000417644.1_RNA|GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	314						integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CGAGGTGGTCCGGGGATTCAC	0.597000													5	290					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120707	38120707	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:38120707C>T	ENST00000406386.3	+	7	2399	c.2144C>T	c.(2143-2145)aCc>aTc	p.T715I	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	715				RTTQQEN -> KSTFGCL (in Ref. 7; BAB33332).	actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AACAGAACCACCCAACAAGAG	0.577000													6	346					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167870912	167870912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:167870912G>A	ENST00000367848.1	-	5	645	c.148C>T	c.(148-150)Cga>Tga	p.R50*	ADCY10_ENST00000545172.1_Intron|ADCY10_ENST00000367851.4_Nonsense_Mutation_p.R142*			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	142	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						ATCTTGACTCGGATGTCTAGG	0.463000													59	447					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38130478	38130478	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:38130478C>T	ENST00000406386.3	+	9	4390	c.4135C>T	c.(4135-4137)Cct>Tct	p.P1379S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1379					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TCCTTGGAGTCCTGAGAAGAG	0.652000													6	79					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292241	33292241	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr14:33292241C>T	ENST00000280979.4	+	13	5392	c.5222C>T	c.(5221-5223)tCt>tTt	p.S1741F	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1741					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTTAATGTCTCTTGCACCTCT	0.473000													52	364					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215408265	215408265	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:215408265A>C	ENST00000444842.2	+	7	1208	c.1058A>C	c.(1057-1059)gAc>gCc	p.D353A	KCNK2_ENST00000391894.2_Missense_Mutation_p.D338A|KCNK2_ENST00000391895.2_Missense_Mutation_p.D349A	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	353							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	GAGATTTATGACAAGTTCCAG	0.552000													36	216					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135106041	135106041	+	Silent	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:135106041C>T	ENST00000368563.2	-	8	1532	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	TUBGCP2_ENST00000417178.2_Silent_p.E262E|TUBGCP2_ENST00000252936.3_Silent_p.E392E|TUBGCP2_ENST00000543663.1_Silent_p.E420E	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	392					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		AGATCCACTTCTCCAGAACCT	0.627000													24	160					0	0	1	0	0
RPP14	11102	broad.mit.edu	37	3	58302276	58302276	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr3:58302276A>C	ENST00000445193.2	+	4	608	c.197A>C	c.(196-198)tAt>tCt	p.Y66S	RPP14_ENST00000477305.1_3'UTR|RPP14_ENST00000466547.1_Missense_Mutation_p.Y66S|RPP14_ENST00000544156.1_5'UTR|RPP14_ENST00000295959.5_Missense_Mutation_p.Y66S	NM_001098783.2	NP_001092253.1	O95059	RPP14_HUMAN	ribonuclease P/MRP 14kDa subunit	66					tRNA processing	nucleus	identical protein binding|ribonuclease P activity|RNA binding			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000187)|KIRC - Kidney renal clear cell carcinoma(10;0.0102)|Kidney(10;0.0118)|OV - Ovarian serous cystadenocarcinoma(275;0.191)		ATCCTAACCTATGAAGAGAAG	0.418000													65	426					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30999101	30999101	+	Silent	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr8:30999101C>T	ENST00000298139.5	+	25	3372	c.3123C>T	c.(3121-3123)tgC>tgT	p.C1041C		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1041					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding	p.C1041C(1)		central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TGAAGATTTGCGCCCTTACGA	0.403000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				5	470					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872537	55872537	+	Missense_Mutation	SNP	A	A	G	rs61746549	byFrequency	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:55872537A>G	ENST00000313503.1	+	1	19	c.19A>G	c.(19-21)Aac>Gac	p.N7D		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.N7D(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TAGAAGGAATAACACAAATGT	0.438000										HNSCC(53;0.14)			5	621					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640850	179640850	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:179640850G>A	ENST00000589042.1	-	28	5965	c.5741C>T	c.(5740-5742)gCg>gTg	p.A1914V	TTN_ENST00000359218.5_Missense_Mutation_p.A1868V|TTN_ENST00000342992.6_Missense_Mutation_p.A1914V|TTN_ENST00000342175.6_Missense_Mutation_p.A1868V|TTN_ENST00000591111.1_Missense_Mutation_p.A1914V|TTN_ENST00000460472.2_Missense_Mutation_p.A1868V|TTN_ENST00000360870.5_Missense_Mutation_p.A1914V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1632	Ig-like 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.A1868V(4)|p.A1914V(4)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGATTTTCCGCGGTGACCTT	0.458000													118	677					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71883405	71883405	+	Silent	SNP	G	G	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:71883405G>C	ENST00000258104.3	+	42	4900	c.4623G>C	c.(4621-4623)gtG>gtC	p.V1541V	DYSF_ENST00000413539.2_Silent_p.V1572V|DYSF_ENST00000409651.1_Silent_p.V1573V|DYSF_ENST00000410041.1_Silent_p.V1559V|DYSF_ENST00000410020.3_Silent_p.V1580V|DYSF_ENST00000409366.1_Silent_p.V1563V|DYSF_ENST00000394120.2_Silent_p.V1542V|DYSF_ENST00000409582.3_Silent_p.V1579V|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000409744.1_Silent_p.V1549V|DYSF_ENST00000429174.2_Silent_p.V1562V|DYSF_ENST00000409762.1_Silent_p.V1558V	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1541						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATCCATCTGTGATTGGTGAAT	0.517000													10	1143					0	0	1	0	0
ZNF426	79088	broad.mit.edu	37	19	9639110	9639110	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:9639110G>A	ENST00000593003.1	-	6	1974	c.1497C>T	c.(1495-1497)tgC>tgT	p.C499C	ZNF426_ENST00000535489.1_Silent_p.C537C|ZNF426_ENST00000253115.2_Silent_p.C537C			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	537					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						AAGCTTTCCCGCATTGCTGAC	0.408000													5	363					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536020	129536020	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:129536020G>C	ENST00000388920.4	+	1	522	c.483G>C	c.(481-483)aaG>aaC	p.K161N		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	161					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				ACTGCTTCAAGAAGGTGCCCC	0.662000													15	56					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38130531	38130531	+	Silent	SNP	C	C	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:38130531C>T	ENST00000406386.3	+	9	4443	c.4188C>T	c.(4186-4188)ccC>ccT	p.P1396P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1396					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CGCTGCCCCCCAGGACATCAG	0.657000													7	44					0	0	1	0	0
COL6A2	0	broad.mit.edu	37	21	47549168	47549168	+	Silent	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr21:47549168G>A	ENST00000357838.4	+	28	2602	c.2520G>A	c.(2518-2520)ccG>ccA	p.P840P	COL6A2_ENST00000397763.1_Silent_p.P840P|COL6A2_ENST00000310645.5_3'UTR|COL6A2_ENST00000409416.1_3'UTR|COL6A2_ENST00000300527.4_Intron	NM_058174.2	NP_478054.2	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	577	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AAGAGGGGCCGGACGCCACCT	0.677000													40	467					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													7	540					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432939	30432939	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr20:30432939G>A	ENST00000375978.3	-	1	481	c.407C>T	c.(406-408)gCg>gTg	p.A136V		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	136					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CTGGCTGGTCGCCCTGAGGGG	0.706000													11	71					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64502748	64502748	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr12:64502748G>A	ENST00000355086.3	+	16	2374	c.1850G>A	c.(1849-1851)cGc>cAc	p.R617H	SRGAP1_ENST00000543397.1_Missense_Mutation_p.R554H|RP11-196H14.4_ENST00000535806.1_RNA|SRGAP1_ENST00000357825.3_Missense_Mutation_p.R594H	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	617	Rho-GAP.				axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CTTCACATCCGCAAACTCCTC	0.463000													6	504					0	0	1	0	0
POU3F3	5455	broad.mit.edu	37	2	105473188	105473188	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:105473188G>A	ENST00000361360.2	+	1	1220	c.1220G>A	c.(1219-1221)cGc>cAc	p.R407H	RP11-13J10.1_ENST00000598623.1_RNA	NM_006236.1	NP_006227.1	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	407					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12						GGCCGCAAGCGCAAGAAGCGG	0.647000													4	142					0	0	1	0	0
TEPP	374739	broad.mit.edu	37	16	58011728	58011728	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr16:58011728G>A	ENST00000290871.5	+	2	210	c.173G>A	c.(172-174)cGc>cAc	p.R58H	TEPP_ENST00000569996.1_Intron|TEPP_ENST00000441824.2_Missense_Mutation_p.R58H	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	58						extracellular region				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						GCTATGGCCCGCATCATTGAC	0.632000													6	696					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76949326	76949326	+	Silent	SNP	G	G	T			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chrX:76949326G>T	ENST00000373344.5	-	6	685	c.471C>A	c.(469-471)ctC>ctA	p.L157L	ATRX_ENST00000373341.1_Silent_p.L118L|ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Intron	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	157					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CGCGTTTTTTGAGATTTTCAG	0.348000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						11	301					1.55795e-14	1.63488e-14	1	1	0
MUC16	94025	broad.mit.edu	37	19	9047851	9047851	+	Silent	SNP	C	C	T	rs149660691	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:9047851C>T	ENST00000397910.4	-	5	33983	c.33780G>A	c.(33778-33780)ccG>ccA	p.P11260P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11262	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATTTGTAAACGGCTCACCAG	0.478000													6	125					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244155	56244155	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:56244155T>C	ENST00000332836.2	-	2	1069	c.1042A>G	c.(1042-1044)Aaa>Gaa	p.K348E		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	348	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGCCTCTGTTTCACACAAGTA	0.418000													53	449					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958910	53958910	+	RNA	SNP	A	A	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:53958910A>G	ENST00000454407.1	+	0	1602							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K329K(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AACCCTACAAATGTAATGAGT	0.413000													8	817					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109975	145109976	+	RNA	INS	-	-	C	rs67257307		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													4	8	---	---	---	---					
SPRR4	163778	broad.mit.edu	37	1	152944390	152944392	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr1:152944390_152944392delGCA	ENST00000328051.2	+	2	73_75	c.24_26delGCA	c.(22-27)cgg>cg	p.RQ8del		NM_173080.1	NP_775103.1	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	8	Gln-rich.				keratinization|peptide cross-linking	cell cortex				lung(1)|prostate(1)	2	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			agcagcagcggcagcagcagcag	0.552													7	601	---	---	---	---					
CH17-132F21.1	0	broad.mit.edu	37	2	90458648	90458648	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr2:90458648delT	ENST00000603238.1	+	2	324	c.324delT	c.(322-324)tgfs	p.108fs																								CTTATTACTGTCAACAGAGTG	0.512													8	3507	---	---	---	---					
FAM86JP	0	broad.mit.edu	37	3	125647339	125647339	+	RNA	DEL	C	C	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr3:125647339delC	ENST00000485843.1	+	0	484					NR_024251.1																						TGTTTCCAGGCCAGGCCAGGA	0.557													7	360	---	---	---	---					
TMCC1	23023	broad.mit.edu	37	3	129370576	129370578	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr3:129370576_129370578delCTG	ENST00000393238.3	-	6	2048_2050	c.1708_1710delCAG	c.(1708-1710)del	p.Q570del	TMCC1_ENST00000432054.2_In_Frame_Del_p.Q246del|TMCC1_ENST00000329333.5_In_Frame_Del_p.Q391del|TMCC1_ENST00000426664.2_In_Frame_Del_p.Q456del	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	570						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GCTGCACCACCTGCTGCTGCTGC	0.581													9	405	---	---	---	---					
MUC4	4585	broad.mit.edu	37	3	195512373	195512374	+	In_Frame_Ins	INS	-	-	GAT	rs63118461	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr3:195512373_195512374insGAT	ENST00000463781.3	-	2	6536_6537	c.6077_6078insATC	c.(6076-6078)tac>tATCac	p.2026_2027insH	MUC4_ENST00000475231.1_In_Frame_Ins_p.2026_2027insH|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	798					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.S2026_T2027insS(3)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCACCAGTGGATGCTGAGGA	0.579													5	3	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													11	305	---	---	---	---					
ARHGAP10	79658	broad.mit.edu	37	4	148984411	148984411	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr4:148984411delT	ENST00000336498.3	+	21	2379	c.2140delT	c.(2140-2142)ttfs	p.F714fs	ARHGAP10_ENST00000414545.2_Intron	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	714					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CCCTTTCCCCTTTTCTCCTCC	0.542													36	187	---	---	---	---					
FBXW7	0	broad.mit.edu	37	4	153249472	153249473	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr4:153249472_153249473insAA	ENST00000281708.4	-	9	2534_2535	c.1305_1306insTT	c.(1303-1308)atgtggfs	p.MW435fs	FBXW7_ENST00000393956.3_Frame_Shift_Ins_p.MW259fs|FBXW7_ENST00000603548.1_Frame_Shift_Ins_p.MW435fs|FBXW7_ENST00000263981.5_Frame_Shift_Ins_p.MW355fs|FBXW7_ENST00000296555.5_Frame_Shift_Ins_p.MW317fs|FBXW7_ENST00000603841.1_Frame_Shift_Ins_p.MW435fs	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	435					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GTAGATCCACTAATGATGATGT	0.416			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								102	665	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32523362	32523363	+	RNA	INS	-	-	GATA	rs142676080	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:32523362_32523363insGATA	ENST00000411500.1	-	0	458					NR_001298.1																						AAAGCAATGTGGATAAAGGGAC	0.431													7	21	---	---	---	---					
GRM1	2911	broad.mit.edu	37	6	146755630	146755632	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr6:146755630_146755632delGAC	ENST00000361719.2	+	9	3753_3755	c.3283_3285delGAC	c.(3283-3285)del	p.D1099del	GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000282753.1_In_Frame_Del_p.D1099del|GRM1_ENST00000392299.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	1099	Asp/Glu-rich (acidic).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCGCCCGCGGACGACGACGACG	0.650													7	633	---	---	---	---					
OSBPL3	26031	broad.mit.edu	37	7	24910452	24910453	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr7:24910452_24910453delTC	ENST00000313367.2	-	5	730_731	c.279_280delGA	c.(277-282)gaagfs	p.EK93fs	OSBPL3_ENST00000409069.1_Frame_Shift_Del_p.EK93fs|OSBPL3_ENST00000396429.1_Frame_Shift_Del_p.EK93fs|OSBPL3_ENST00000353930.1_Frame_Shift_Del_p.EK93fs|OSBPL3_ENST00000396431.1_Frame_Shift_Del_p.EK93fs|OSBPL3_ENST00000352860.1_Frame_Shift_Del_p.EK93fs|OSBPL3_ENST00000431825.2_Frame_Shift_Del_p.EK93fs	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	93	PH.				lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CCATGCAGCTTCTCTCTCTCTA	0.500													7	408	---	---	---	---					
DTX2	113878	broad.mit.edu	37	7	76112249	76112249	+	Frame_Shift_Del	DEL	A	A	-	rs147779783	byFrequency	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr7:76112249delA	ENST00000324432.5	+	5	1203	c.693delA	c.(691-693)ccfs	p.P231fs	DTX2_ENST00000446820.2_Frame_Shift_Del_p.P231fs|DTX2_ENST00000446600.1_Frame_Shift_Del_p.P140fs|DTX2_ENST00000430490.2_Frame_Shift_Del_p.P231fs|DTX2_ENST00000307569.8_Frame_Shift_Del_p.P231fs|DTX2_ENST00000413936.2_Frame_Shift_Del_p.P231fs	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	231					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						AGCACCCCCCACACAGGACCG	0.657													8	1385	---	---	---	---					
NR4A3	0	broad.mit.edu	37	9	102590616	102590618	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr9:102590616_102590618delCAC	ENST00000330847.1	+	2	369_371	c.325_327delCAC	c.(325-327)del	p.H119del	NR4A3_ENST00000338488.4_In_Frame_Del_p.H108del|NR4A3_ENST00000395097.2_In_Frame_Del_p.H108del			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	108					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ccatcaccatcaccaccaccacc	0.616			T	EWSR1	extraskeletal myxoid chondrosarcoma								7	182	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139390945	139390947	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr9:139390945_139390947delGTG	ENST00000277541.6	-	34	7319_7321	c.7244_7246delCAC	c.(7243-7248)cag>c	p.PQ2415del		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2415	Poly-Pro.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.Q2417*(2)|p.P2416fs*11(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTGCGGCTGTGGTGGTGGTGG	0.650			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			7	219	---	---	---	---					
ZSWIM8	23053	broad.mit.edu	37	10	75560463	75560464	+	Frame_Shift_Ins	INS	-	-	C			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:75560463_75560464insC	ENST00000604729.1	+	24	5365_5366	c.5068_5069insC	c.(5068-5070)cccfs	p.P1690fs	ZSWIM8_ENST00000398706.2_Frame_Shift_Ins_p.P1698fs|ZSWIM8_ENST00000603114.1_Frame_Shift_Ins_p.P1652fs|NDST2_ENST00000456638.1_Intron|ZSWIM8_ENST00000604524.1_Frame_Shift_Ins_p.P1511fs|ZSWIM8_ENST00000605216.1_Frame_Shift_Ins_p.P1693fs					zinc finger, SWIM-type containing 8																		CTTCTCCCGCTCCCCCCCCTAC	0.604													13	512	---	---	---	---					
LINC00502	0	broad.mit.edu	37	10	92813180	92813180	+	RNA	DEL	A	A	-	rs111380766		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:92813180delA	ENST00000423621.1	+	0	264																											TGGGCCTGATAAAAAAAAAGC	0.343													7	84	---	---	---	---					
CPXM2	119587	broad.mit.edu	37	10	125528165	125528167	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr10:125528165_125528167delCAG	ENST00000241305.3	-	9	1328_1330	c.1174_1176delCTG	c.(1174-1176)del	p.L392del	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	392	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGAACTGCACCAGCAGCAGCAGC	0.626													8	686	---	---	---	---					
KCNA4	3739	broad.mit.edu	37	11	30034029	30034031	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:30034029_30034031delTGG	ENST00000328224.6	-	2	1428_1430	c.195_197delCCA	c.(193-198)cag>ca	p.HQ65del		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	65	Poly-His.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCGCGTGACTGGTGGTGGTGGT	0.660													8	325	---	---	---	---					
EHF	26298	broad.mit.edu	37	11	34667997	34667997	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:34667997delT	ENST00000257831.3	+	3	230	c.109delT	c.(109-111)ttfs	p.F38fs	EHF_ENST00000531794.1_Frame_Shift_Del_p.F60fs|EHF_ENST00000530286.1_Frame_Shift_Del_p.F38fs|EHF_ENST00000527935.1_Frame_Shift_Del_p.F38fs|EHF_ENST00000531728.1_Frame_Shift_Del_p.F38fs|EHF_ENST00000533754.1_Frame_Shift_Del_p.F38fs|EHF_ENST00000450654.2_Frame_Shift_Del_p.F38fs|EHF_ENST00000527001.1_3'UTR	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	38	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.F38fs*51(1)	NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTCCAGTGGGTTTTTTGGAGG	0.537													7	669	---	---	---	---					
BCL9L	283149	broad.mit.edu	37	11	118773004	118773004	+	Frame_Shift_Del	DEL	G	G	-	rs147951163	byFrequency	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr11:118773004delG	ENST00000334801.3	-	6	2412	c.1448delC	c.(1447-1449)cgfs	p.P483fs	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	483	Necessary for interaction with CTNNB1 (By similarity).|Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		ATGCTCCAGCGGGGGGCCCCC	0.642													7	743	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95696016	95696016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr13:95696016delT	ENST00000376887.4	-	29	3769	c.3655delA	c.(3655-3657)tcfs	p.I1219fs	ABCC4_ENST00000412704.1_Frame_Shift_Del_p.I1172fs	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1219	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCTCCCGGATTTTTTTTTGT	0.378													9	410	---	---	---	---					
DDX24	57062	broad.mit.edu	37	14	94545821	94545823	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr14:94545821_94545823delCCT	ENST00000330836.5	-	2	397_399	c.266_268delAGG	c.(265-270)gga>g	p.EG89del	DDX24_ENST00000544005.1_Intron|DDX24_ENST00000555054.1_In_Frame_Del_p.EG46del	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	89	Poly-Glu.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CTAGACTTTCCCTCCTCCTCCTC	0.443													8	666	---	---	---	---					
KIAA0430	9665	broad.mit.edu	37	16	15729982	15729984	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr16:15729982_15729984delCCA	ENST00000396368.3	-	3	566_568	c.360_362delTGG	c.(358-363)ggc>gg	p.GG120del	KIAA0430_ENST00000540441.2_In_Frame_Del_p.GG120del|KIAA0430_ENST00000344181.3_5'UTR|KIAA0430_ENST00000551742.1_In_Frame_Del_p.GG120del|KIAA0430_ENST00000602337.1_In_Frame_Del_p.GG120del|KIAA0430_ENST00000548025.1_In_Frame_Del_p.GG120del	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	119	Poly-Gly.					peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TCCGCTACCGCCACCACCACCAC	0.532													8	499	---	---	---	---					
ACD	65057	broad.mit.edu	37	16	67693646	67693648	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr16:67693646_67693648delGCA	ENST00000219251.8	-	3	873_875	c.542_544delTGC	c.(541-546)cag>c	p.LQ181del	ACD_ENST00000393919.4_In_Frame_Del_p.LQ184del	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	184					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding	p.L181delL(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCGCAGTCCTGCAGCAGCAGCAG	0.650													7	569	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578213	7578213	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr17:7578213delA	ENST00000420246.2	-	6	768	c.636delT	c.(634-636)ttfs	p.F212fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.F212fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Frame_Shift_Del_p.F212fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.F212fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	212	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		F -> I (in sporadic cancers; somatic mutation).|F -> L (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in a sporadic cancer; somatic mutation).|F -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.F212fs*3(6)|p.?(5)|p.R213fs*35(3)|p.F212L(2)|p.D208fs*1(1)|p.R209_R213delRNTFR(1)|p.F119fs*3(1)|p.T211fs*28(1)|p.D207_R213delDDRNTFR(1)|p.D207_V216del10(1)|p.T211_S215delTFRHS(1)|p.F80fs*3(1)|p.R120fs*35(1)|p.R209fs*6(1)|p.R81fs*>11(1)|p.D208_V216delDRNTFRHSV(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTATGTCGAAAAGTGTTTC	0.532		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	160	---	---	---	---					
GRIN3B	116444	broad.mit.edu	37	19	1003526	1003527	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:1003526_1003527delCA	ENST00000234389.3	+	2	843_844	c.824_825delCA	c.(823-825)cfs	p.P276fs		NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	276					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCGGGGCTGCCACCAGGGCTGC	0.748													2	4	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tcgtfs	p.SR342fs	HAUS8_ENST00000448593.2_Frame_Shift_Del_p.SR402fs|HAUS8_ENST00000253669.5_Frame_Shift_Del_p.SR403fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	403					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													8	894	---	---	---	---					
FCAR	2204	broad.mit.edu	37	19	55396764	55396765	+	Frame_Shift_Ins	INS	-	-	A	rs144393831	by1000genomes	TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr19:55396764_55396765insA	ENST00000355524.3	+	3	198_199	c.188_189insA	c.(187-189)aaafs	p.K63fs	FCAR_ENST00000345937.4_Frame_Shift_Ins_p.K63fs|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000469767.1_Frame_Shift_Ins_p.K63fs|FCAR_ENST00000353758.4_Intron|FCAR_ENST00000391723.3_Frame_Shift_Ins_p.K51fs|FCAR_ENST00000391724.3_Frame_Shift_Ins_p.K51fs|FCAR_ENST00000391725.3_Frame_Shift_Ins_p.K63fs|FCAR_ENST00000391726.3_Frame_Shift_Ins_p.K51fs|FCAR_ENST00000359272.4_Frame_Shift_Ins_p.K51fs	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	63	Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CTGATGATCATAAAAAACTCCA	0.475													35	257	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr20:47989771_47989772insG	ENST00000371741.4	-	2	2491_2492	c.2325_2326insC	c.(2323-2328)ccaaagfs	p.PK775fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	775					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545													7	1612	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131430	17131432	+	RNA	DEL	CAC	CAC	-	rs142037179		TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:17131430_17131432delCAC	ENST00000426585.1	+	0	2456_2458																											caccatccatcaccaacagaaac	0.443													6	9	---	---	---	---					
EWSR1	2130	broad.mit.edu	37	22	29694812	29694813	+	Frame_Shift_Ins	INS	-	-	G			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chr22:29694812_29694813insG	ENST00000397938.2	+	14	1826_1827	c.1507_1508insG	c.(1507-1509)gggfs	p.G503fs	EWSR1_ENST00000414183.2_Frame_Shift_Ins_p.G508fs|EWSR1_ENST00000331029.7_Frame_Shift_Ins_p.G465fs|EWSR1_ENST00000332035.6_Frame_Shift_Ins_p.G447fs|EWSR1_ENST00000406548.1_Frame_Shift_Ins_p.G502fs|EWSR1_ENST00000332050.6_Frame_Shift_Ins_p.G430fs	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	503	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding	p.R503Q(1)	EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AAGAGGACCCCGGGGTTCCCGA	0.604			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								7	502	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639633	149639635	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-2J-AABT-01A-11D-A40W-08	TCGA-2J-AABT-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af1eac7d-1a66-417f-af21-9118d666f77e	79a263d5-26dd-4f6d-b97d-14c14f0bbce5	g.chrX:149639633_149639635delGCA	ENST00000370401.2	+	4	2098_2100	c.1788_1790delGCA	c.(1786-1791)ctg>ct	p.LQ596del	MAMLD1_ENST00000455522.2_In_Frame_Del_p.LQ77del|MAMLD1_ENST00000426613.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000262858.5_In_Frame_Del_p.LQ596del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	596	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTgcagctgcagcagcagcag	0.611													9	494	---	---	---	---					
