Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCT8	10694	broad.mit.edu	37	21	30440001	30440001	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr21:30440001A>G	ENST00000286788.4	-	4	463	c.257T>C	c.(256-258)aTt>aCt	p.I86T	CCT8_ENST00000540844.1_Missense_Mutation_p.I13T|CCT8_ENST00000542732.1_Missense_Mutation_p.I67T|CCT8_ENST00000470450.1_5'UTR	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	86					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						AGCCATTACAATCATTTTTGC	0.368000													6	400					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31740382	31740382	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr22:31740382G>A	ENST00000266269.5	-	1	1836	c.1207C>T	c.(1207-1209)Cgg>Tgg	p.R403W	PATZ1_ENST00000351933.4_Missense_Mutation_p.R403W|PATZ1_ENST00000215919.3_Missense_Mutation_p.R403W|PATZ1_ENST00000405309.3_Missense_Mutation_p.R403W	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	403					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TCATGGGACCGCACATGGTAG	0.592000													5	430					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													8	265					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127622522	127622522	+	Silent	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:127622522T>C	ENST00000508053.1	-	61	7874	c.6900A>G	c.(6898-6900)gaA>gaG	p.E2300E	FBN2_ENST00000262464.4_Silent_p.E2300E			P35556	FBN2_HUMAN	fibrillin 2	2300	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CGTGTAACCCTTCAGCACATT	0.433000													5	220					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16295884	16295884	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:16295884C>T	ENST00000205557.7	-	9	1179	c.1150G>A	c.(1150-1152)Gcc>Acc	p.A384T	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	384	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCAGTGATGGCCGACCGCAAC	0.572000													8	516					0	0	1	0	0
HMGB1	3146	broad.mit.edu	37	13	31035512	31035512	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:31035512T>A	ENST00000405805.1	-	5	1570	c.630A>T	c.(628-630)gaA>gaT	p.E210D	HMGB1_ENST00000341423.5_Missense_Mutation_p.E210D|HMGB1_ENST00000399494.1_Missense_Mutation_p.E210D|HMGB1_ENST00000339872.4_Missense_Mutation_p.E210D|HMGB1_ENST00000399489.1_3'UTR			P09429	HMGB1_HUMAN	high mobility group box 1	210	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(1)|ovary(1)	8		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CATCAtcatcttcttcttcat	0.378000													5	194					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203054698	203054698	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:203054698C>A	ENST00000241651.4	-	1	466	c.392G>T	c.(391-393)cGc>cTc	p.R131L		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	131	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						GGCCTGGAGGCGCTCGATGTA	0.672000													11	348					0.000978159	0.000994738	1	1	0
INPP5K	51763	broad.mit.edu	37	17	1401275	1401275	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:1401275G>A	ENST00000406424.4	-	10	1550	c.690C>T	c.(688-690)taC>taT	p.Y230Y	INPP5K_ENST00000421807.2_Silent_p.Y306Y|INPP5K_ENST00000320345.6_Silent_p.Y230Y|INPP5K_ENST00000542125.1_Silent_p.Y210Y|INPP5K_ENST00000397335.3_Silent_p.Y214Y	NM_001135642.1	NP_001129114.1	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K	306	Catalytic (Potential).				actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding			endometrium(1)|large_intestine(7)|lung(3)|skin(1)	12						CGCTGATGCCGTACGTCATGT	0.607000													6	925					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41719747	41719747	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr21:41719747G>T	ENST00000400454.1	-	6	1537	c.1060C>A	c.(1060-1062)Ctc>Atc	p.L354I		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	354	Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCAGGGTTGAGGATTTCACCA	0.498000													53	1477					6.50621e-10	6.88893e-10	1	1	0
ARRB2	409	broad.mit.edu	37	17	4619828	4619828	+	Silent	SNP	A	A	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:4619828A>C	ENST00000269260.2	+	5	515	c.282A>C	c.(280-282)ccA>ccC	p.P94P	ARRB2_ENST00000346341.2_Silent_p.P79P|ARRB2_ENST00000381488.6_Silent_p.P79P|ARRB2_ENST00000574954.1_5'UTR|ARRB2_ENST00000412477.3_Silent_p.P94P|ARRB2_ENST00000570718.1_3'UTR|ARRB2_ENST00000571206.1_5'UTR|ARRB2_ENST00000575877.1_Silent_p.P94P|ARRB2_ENST00000572457.1_5'UTR	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	94					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding			large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						TGCCCAACCCACCCCGGCCCC	0.667000													13	66					0	0	1	0	0
COX16	51241	broad.mit.edu	37	14	70826257	70826257	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:70826257G>A	ENST00000389912.6	-	1	191	c.48C>T	c.(46-48)ctC>ctT	p.L16L	RP11-718G2.3_ENST00000555276.1_RNA|COX16_ENST00000557612.1_5'UTR	NM_016468.6	NP_057552.1			COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)											large_intestine(1)|lung(2)	3						CTCCATAGCCGAGAGTCTTGT	0.577000													14	285					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241557	47241557	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:47241557G>A	ENST00000300404.2	+	8	1113	c.1054G>A	c.(1054-1056)Gta>Ata	p.V352I	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.V266I|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.V292I	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	352					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			AGACTTGACCGTAATAGTGGC	0.488000													6	980					0	0	1	0	0
IGHV3-13	0	broad.mit.edu	37	14	106586383	106586383	+	RNA	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:106586383C>T	ENST00000390602.2	-	0	181																											TCAGGGACCCCCCAGGCTGTA	0.562000													6	855					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46939361	46939361	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:46939361G>A	ENST00000313049.5	+	4	533	c.330G>A	c.(328-330)ccG>ccA	p.P110P	PTH1R_ENST00000449590.1_Silent_p.P110P|PTH1R_ENST00000430002.2_Silent_p.P110P|PTH1R_ENST00000418619.1_Silent_p.P110P|PTH1R_ENST00000490109.1_3'UTR			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	110						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						CCTGTCTGCCGGAATGGGACC	0.572000													7	221					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252865	50252865	+	RNA	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:50252865T>C	ENST00000420502.1	+	0	500							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	TCCATCCACCTGCTACTCAAG	0.587000													9	482					0	0	1	0	0
IQCJ	654502	broad.mit.edu	37	3	158983022	158983022	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:158983022G>A	ENST00000482126.1	+	4	334	c.229G>A	c.(229-231)Ggg>Agg	p.G77R	IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ_ENST00000451172.1_Missense_Mutation_p.G104R|IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000485419.1_Intron	NM_001197100.1	NP_001184029.1			IQ motif containing J											cervix(1)|endometrium(2)|large_intestine(2)|lung(10)	15			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			GGCCCCTGTTGGGAAGATTCA	0.448000													22	619					0	0	1	0	0
FAM86C2P	0	broad.mit.edu	37	11	67564228	67564228	+	RNA	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:67564228C>T	ENST00000528089.1	-	0	912																											GAGGAGCCCGCTGGTGCTCCC	0.627000													5	281					0	0	1	0	0
MIR329-1	0	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	A	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:101493161A>T	ENST00000385028.1	+	0	40					NR_029967.1																						TGTTTCTTTAATGAGGACGAA	0.468000													11	979					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75139533	75139533	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:75139533C>T	ENST00000356357.4	-	11	1938		c.e11+1		AREL1_ENST00000557401.1_Splice_Site	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		ATTTTACCTACCGATTCCAAC	0.403000													8	847					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43619215	43619215	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:43619215C>T	ENST00000355710.3	+	17	3130	c.2898C>T	c.(2896-2898)acC>acT	p.T966T	RET_ENST00000340058.5_Silent_p.T966T	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	966	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.T966T(1)	CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TTCTGAAGACCGGCCACCGGA	0.602000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	502					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367485.4_Silent_p.K617K|PRG4_ENST00000367483.4_Silent_p.K669K|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													7	662					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76497387	76497387	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:76497387G>A	ENST00000389840.5	-	35	5444	c.5320C>T	c.(5320-5322)Cgg>Tgg	p.R1774W	DNAH17-AS1_ENST00000598378.1_3'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.R1783W					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGCGATGCCGGAGCTGGGCC	0.582000													4	257					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36778971	36778971	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:36778971C>G	ENST00000416516.2	-	2	1670	c.1180G>C	c.(1180-1182)Ggc>Cgc	p.G394R		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	394	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TCCTCCTTGCCCTTGAGTCTG	0.507000													11	302					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77917637	77917637	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:77917637C>T	ENST00000553888.1	-	4	746	c.236G>A	c.(235-237)gGc>gAc	p.G79D	VIPAS39_ENST00000448935.2_Intron|VIPAS39_ENST00000343765.2_Missense_Mutation_p.G79D|VIPAS39_ENST00000327028.4_Missense_Mutation_p.G79D|VIPAS39_ENST00000557658.1_Missense_Mutation_p.G79D|VIPAS39_ENST00000556412.1_Missense_Mutation_p.G105D	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		GTGGGTTGAGCCGCTATTACC	0.483000													7	968					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70989431	70989431	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:70989431T>C	ENST00000256389.3	-	2	2438	c.2194A>G	c.(2194-2196)Atg>Gtg	p.M732V	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	682					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		AATCCTTCCATGTTGTTCTTA	0.428000													6	796					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665290	179665290	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:179665290G>A	ENST00000589042.1	-	4	639	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	TTN_ENST00000360870.5_Missense_Mutation_p.R139W|TTN_ENST00000359218.5_Missense_Mutation_p.R139W|TTN_ENST00000342992.6_Missense_Mutation_p.R139W|TTN_ENST00000591111.1_Missense_Mutation_p.R139W|TTN_ENST00000342175.6_Missense_Mutation_p.R139W|TTN_ENST00000460472.2_Missense_Mutation_p.R139W	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	139	Ig-like 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCCATCCCGGTAGAACTTC	0.507000													6	614					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156981	26156981	+	Missense_Mutation	SNP	A	A	T	rs142089484		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:26156981A>T	ENST00000304218.3	+	1	423	c.363A>T	c.(361-363)aaA>aaT	p.K121N		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	121					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						CTAAGGCTAAAAAGGCAGGCG	0.642000													17	160					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32155509	32155509	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:32155509T>A	ENST00000375050.4	-	5	1055	c.785A>T	c.(784-786)tAt>tTt	p.Y262F		NM_002586.4	NP_002577.2	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	262							transcription factor binding	p.Y262F(3)		endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						GGAGTAGAAATACTCATTTAG	0.517000													4	90					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84695471	84695471	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:84695471G>A	ENST00000564996.1	+	5	1724	c.1583G>A	c.(1582-1584)cGc>cAc	p.R528H	KLHL36_ENST00000258157.5_Missense_Mutation_p.R465H	NM_024731.2	NP_079007.2	Q8N4N3	KLH36_HUMAN	kelch-like family member 36	528										endometrium(3)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						CAGTGGACCCGCGTGGCGCCG	0.657000													15	125					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013810	75013810	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:75013810G>A	ENST00000379727.3	-	4	1185	c.987C>T	c.(985-987)agC>agT	p.S329S	CYP1A1_ENST00000567032.1_Silent_p.S329S|CYP1A1_ENST00000395049.4_Silent_p.S329S|CYP1A1_ENST00000395048.2_Silent_p.S329S|CYP1A1_ENST00000564596.1_Silent_p.S68S			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	329					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	AATACATGAGGCTCCAGGAGA	0.542000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				43	265					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127323603	127323603	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:127323603G>A	ENST00000265056.7	+	3	633	c.389G>A	c.(388-390)cGc>cAc	p.R130H		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	130	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GGCCTGGGCCGCATGCGCCGT	0.677000													4	85					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269953	1269953	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:1269953T>C	ENST00000447027.1	+	31	11910	c.11852T>C	c.(11851-11853)aTc>aCc	p.I3951T	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.I3948T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3948	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ccatcactgatcaccacggcc	0.617000													4	65					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20108795	20108795	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:20108795G>T	ENST00000395530.2	+	2	1398	c.1190G>T	c.(1189-1191)cGc>cTc	p.R397L	SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000536879.1_Intron|SPECC1_ENST00000395522.2_Missense_Mutation_p.R397L|SPECC1_ENST00000395525.3_Missense_Mutation_p.R397L|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000395529.3_Missense_Mutation_p.R478L|SPECC1_ENST00000261503.5_Missense_Mutation_p.R478L|SPECC1_ENST00000395527.4_Missense_Mutation_p.R478L	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	478						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		GAACAGGGCCGCTTTGAAAGA	0.428000													16	413					7.07596e-05	7.23678e-05	1	1	0
ROBO2	6092	broad.mit.edu	37	3	77645801	77645801	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:77645801T>A	ENST00000461745.1	+	19	3654	c.2754T>A	c.(2752-2754)gaT>gaA	p.D918E	ROBO2_ENST00000487694.3_Missense_Mutation_p.D934E|ROBO2_ENST00000332191.8_Missense_Mutation_p.D918E	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	918					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATGCTGGTGATCCCAGCTATC	0.453000													85	605					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													6	552					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114269973	114269973	+	Silent	SNP	A	A	G	rs149757187		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:114269973A>G	ENST00000393500.3	+	11	1105	c.285A>G	c.(283-285)caA>caG	p.Q95Q	FOXP2_ENST00000393494.2_Silent_p.Q170Q|FOXP2_ENST00000378237.3_Silent_p.Q170Q|FOXP2_ENST00000393491.3_Silent_p.Q78Q|FOXP2_ENST00000393498.2_Silent_p.Q150Q|FOXP2_ENST00000403559.4_Silent_p.Q187Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000350908.4_Silent_p.Q170Q|FOXP2_ENST00000390668.3_Silent_p.Q194Q|FOXP2_ENST00000393489.3_Silent_p.Q78Q|FOXP2_ENST00000360232.4_Silent_p.Q170Q|FOXP2_ENST00000408937.3_Silent_p.Q195Q			O15409	FOXP2_HUMAN	forkhead box P2	170	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcagcagcaacaacaacaac	0.502000													5	276					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19067868	19067868	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:19067868C>T	ENST00000421369.3	+	14	2104	c.1546C>T	c.(1546-1548)Cct>Tct	p.P516S	TMC7_ENST00000569532.1_Missense_Mutation_p.P626S|TMC7_ENST00000304381.5_Missense_Mutation_p.P626S	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	626						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TGGCAGCATCCCTTCCTCGAA	0.577000													127	191					0	0	1	0	0
HBP1	26959	broad.mit.edu	37	7	106822943	106822943	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:106822943C>A	ENST00000222574.4	+	3	481	c.295C>A	c.(295-297)Cca>Aca	p.P99T	HBP1_ENST00000485846.1_Missense_Mutation_p.P99T|HBP1_ENST00000468410.1_Missense_Mutation_p.P99T	NM_012257.3	NP_036389.2	O60381	HBP1_HUMAN	HMG-box transcription factor 1	99					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						CTCAGACATACCAGAAACTAC	0.428000													13	466					5.50884e-06	5.6988e-06	1	1	0
PHF13	148479	broad.mit.edu	37	1	6681519	6681519	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:6681519C>T	ENST00000377648.4	+	4	1107	c.725C>T	c.(724-726)gCc>gTc	p.A242V	PHF13_ENST00000495385.1_Intron	NM_153812.2	NP_722519.2	Q86YI8	PHF13_HUMAN	PHD finger protein 13	242	Interaction with trimethylated histone H3 (H3K4).				cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		AAGCCATTTGCCGGCCGCCCC	0.507000													5	363					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63569828	63569828	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:63569828C>T	ENST00000374852.3	-	5	658	c.591G>A	c.(589-591)gaG>gaA	p.E197E	MTMR8_ENST00000453546.1_Silent_p.E197E	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	197	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TTACATTGTTCTCTTTGTAGA	0.403000													5	211					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128689	152128689	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:152128689C>T	ENST00000316073.3	-	3	950	c.886G>A	c.(886-888)Ggt>Agt	p.G296S		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	296	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TCCGTCTGACCGTAGTGGGAA	0.498000													17	2387					0	0	1	0	0
EPS15	2060	broad.mit.edu	37	1	51910708	51910708	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:51910708G>A	ENST00000371733.3	-	11	903	c.807C>T	c.(805-807)tgC>tgT	p.C269C	EPS15_ENST00000371730.2_Silent_p.C269C	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	269	EH 3.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						CCTTTGTGTCGCATAATGACC	0.388000			T	MLL	ALL								5	432					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156982	26156982	+	Nonsense_Mutation	SNP	A	A	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:26156982A>T	ENST00000304218.3	+	1	424	c.364A>T	c.(364-366)Aag>Tag	p.K122*		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	122					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						TAAGGCTAAAAAGGCAGGCGC	0.647000													18	156					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124228837	124228837	+	Silent	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:124228837T>C	ENST00000330342.3	+	11	1527	c.1279T>C	c.(1279-1281)Ttg>Ctg	p.L427L		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	427					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ATTTGCCCTCTTGTTGGTGTT	0.388000													8	652					0	0	1	0	0
YWHAE	7531	broad.mit.edu	37	17	1303373	1303373	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:1303373G>A	ENST00000264335.8	-	1	299	c.32C>T	c.(31-33)gCg>gTg	p.A11V	YWHAE_ENST00000571732.1_5'UTR|YWHAE_ENST00000575977.1_Missense_Mutation_p.A11V|YWHAE_ENST00000573026.1_Missense_Mutation_p.A11V|YWHAE_ENST00000498643.1_5'UTR	NM_006761.4	NP_006752.1	P62258	1433E_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	11					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding	p.A11V(2)		kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		GGCCAGCTTCGCCTGGTACAC	0.657000			T	"""FAM22a, FAM22B"""	edometrial stromal sarcoma		Miller-Dieker lissencephaly syndrome						160	272					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150071135	150071135	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:150071135G>A	ENST00000409642.3	+	7	936	c.535G>A	c.(535-537)Gta>Ata	p.V179I	LYPD6B_ENST00000280115.7_Missense_Mutation_p.V179I|LYPD6B_ENST00000498249.1_3'UTR|LYPD6B_ENST00000409876.1_Missense_Mutation_p.V155I|LYPD6B_ENST00000409029.1_Missense_Mutation_p.V155I	NM_177964.3	NP_808879.2	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	155						anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						AGTGTTTGCCGTAATGCACGC	0.483000													6	733					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								5	295					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51956195	51956195	+	Silent	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:51956195A>G	ENST00000311234.4	-	10	1717	c.1245T>C	c.(1243-1245)taT>taC	p.Y415Y	INTS6_ENST00000497989.1_Silent_p.Y237Y|INTS6_ENST00000425000.1_Intron|INTS6_ENST00000490542.1_Silent_p.Y99Y|INTS6_ENST00000398119.2_Silent_p.Y402Y|INTS6_ENST00000463928.1_Intron	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	415					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		TTGTCTTCAAATAACTTTCAA	0.393000													12	292					0	0	1	0	0
AKAP5	9495	broad.mit.edu	37	14	64935683	64935683	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:64935683G>C	ENST00000320636.5	+	1	1859	c.571G>C	c.(571-573)Ggt>Cgt	p.G191R	ZBTB25_ENST00000555424.1_Intron|AKAP5_ENST00000394718.3_Missense_Mutation_p.G191R|ZBTB25_ENST00000555220.1_Intron			P24588	AKAP5_HUMAN	A kinase (PRKA) anchor protein 5	191					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|stomach(1)	13				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		ACGGAAAGATGGTGATGAGGT	0.408000													6	492					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101553424	101553424	+	Silent	SNP	G	G	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:101553424G>T	ENST00000370449.4	+	4	563	c.450G>T	c.(448-450)ctG>ctT	p.L150L	ABCC2_ENST00000370434.1_Silent_p.L150L|ABCC2_ENST00000496621.1_3'UTR	NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	150						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity	p.L150L(1)		NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCAGACTCTGATCCGGACAC	0.448000													125	178					6.44133e-54	6.98457e-54	1	1	0
ISL1	3670	broad.mit.edu	37	5	50680467	50680467	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:50680467G>A	ENST00000230658.7	+	2	706	c.121G>A	c.(121-123)Gca>Aca	p.A41T	ISL1_ENST00000511384.1_Missense_Mutation_p.A41T	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	41	LIM zinc-binding 1.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				ATGGCATGCGGCATGTTTGAA	0.418000													7	994					0	0	1	0	0
SOX10	6663	broad.mit.edu	37	22	38369614	38369614	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr22:38369614G>A	ENST00000396884.2	-	4	1571	c.1289C>T	c.(1288-1290)cCc>cTc	p.P430L	POLR2F_ENST00000405557.1_Intron|SOX10_ENST00000360880.2_Missense_Mutation_p.P430L|POLR2F_ENST00000407936.1_Intron	NM_006941.3	NP_008872.1	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	430						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity			NS(6)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|skin(2)	20	Melanoma(58;0.045)					CCGCTGCGAGGGCCCCATATA	0.637000													11	282					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389313	1389313	+	Silent	SNP	T	T	C	rs71299249		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:1389313T>C	ENST00000324803.4	+	1	3974	c.1014T>C	c.(1012-1014)tgT>tgC	p.C338C		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	338					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CATGCCGATGTGGAGTGCCCG	0.662000													12	1506					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162579	90162579	+	RNA	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:90162579C>T	ENST00000564451.1	+	0	1932				TUBB8P7_ENST00000567960.1_RNA																							AGGAGTATGCCGAGGAGGAGG	0.512000													8	581					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66765161	66765161	+	Missense_Mutation	SNP	A	A	T	rs71905623		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:66765161A>T	ENST00000374690.3	+	1	697	c.173A>T	c.(172-174)cAg>cTg	p.Q58L	AR_ENST00000504326.1_Missense_Mutation_p.Q58L|AR_ENST00000513847.1_3'UTR|AR_ENST00000396044.3_Missense_Mutation_p.Q58L	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	58	Gln-rich.|Modulating.|Poly-Gln.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding	p.Q58L(2)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CTGCTGCTgcagcagcagcag	0.667000									Androgen Insensitivity Syndrome				5	81					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70903983	70903983	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:70903983G>A	ENST00000264436.3	-	13	1982	c.1538C>T	c.(1537-1539)gCg>gTg	p.A513V	ADD2_ENST00000407644.2_Missense_Mutation_p.A513V|ADD2_ENST00000430656.1_Missense_Mutation_p.A529V|ADD2_ENST00000413157.2_Missense_Mutation_p.A513V|ADD2_ENST00000355733.3_Missense_Mutation_p.A513V	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	513					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CTGAGGCCCCGCTGACTTCAC	0.602000													6	499					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1563731	1563731	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:1563731A>G	ENST00000572621.1	-	29	5045	c.4780T>C	c.(4780-4782)Tgt>Cgt	p.C1594R	PRPF8_ENST00000304992.6_Missense_Mutation_p.C1594R			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1594						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CCCACCTGACATAAGTCCATA	0.522000													827	1280					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276588	186276588	+	Silent	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:186276588T>C	ENST00000445192.2	+	7	1782	c.1737T>C	c.(1735-1737)acT>acC	p.T579T	PRG4_ENST00000367485.4_Silent_p.T486T|PRG4_ENST00000367483.4_Silent_p.T538T|PRG4_ENST00000367486.3_Silent_p.T536T|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	579	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T579T(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTGCCCCAACTACCCCCAAGG	0.647000													17	432					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790192	78790192	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:78790192C>G	ENST00000376767.3	+	14	2559	c.2047C>G	c.(2047-2049)Cga>Gga	p.R683G	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ggaatggaatcgaatcgaatc	0.373000													4	28					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70070185	70070185	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:70070185G>T	ENST00000446444.1	-	5	1281	c.1273C>A	c.(1273-1275)Ctg>Atg	p.L425M	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	425					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GCATTCAGCAGGTCTGTACTC	0.413000													7	987					1.28384e-07	1.35141e-07	1	1	0
AGAP5	729092	broad.mit.edu	37	10	75457349	75457349	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:75457349G>A	ENST00000443782.2	-	1	290	c.165C>T	c.(163-165)acC>acT	p.T55T	AGAP5_ENST00000374094.4_Silent_p.T55T|RP11-464F9.1_ENST00000399449.3_RNA			A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	55					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.T55T(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(5)|skin(1)	12						CAACTTCAACGGTCACCTCAG	0.582000													8	671					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													5	189					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26793020	26793020	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:26793020T>C	ENST00000541819.2	-	10	1612	c.1510A>G	c.(1510-1512)Ata>Gta	p.I504V	GABRB3_ENST00000400188.3_Missense_Mutation_p.I377V|GABRB3_ENST00000311550.5_Missense_Mutation_p.I448V|GABRB3_ENST00000545868.1_Missense_Mutation_p.I363V|GABRB3_ENST00000299267.4_Missense_Mutation_p.I448V			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	448					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CATCTGTCTATGGCATTCACA	0.428000													19	499					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139981660	139981660	+	Nonsense_Mutation	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:139981660C>A	ENST00000371589.4	+	1	282	c.209C>A	c.(208-210)tCg>tAg	p.S70*		NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	70					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CGGCGGCGCTCGTGCTGGAGG	0.721000													3	57					0.00909568	0.00914649	1	1	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													14	502					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12875675	12875675	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:12875675G>A	ENST00000264827.5	-	19	1944	c.1774C>T	c.(1774-1776)Cgg>Tgg	p.R592W	HOOK2_ENST00000397668.3_Missense_Mutation_p.R594W	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	594	Required for localization to the centrosome and induction of aggresome formation.|Sufficient for interaction with CEP110.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						TCCATGGCCCGCAAGTCCGCG	0.627000											OREG0025273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	675					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2266324	2266324	+	Missense_Mutation	SNP	G	G	A	rs146045413		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:2266324G>A	ENST00000268989.3	+	6	745	c.568G>A	c.(568-570)Gat>Aat	p.D190N	SGSM2_ENST00000574563.1_Missense_Mutation_p.D190N|SGSM2_ENST00000574650.1_3'UTR|SGSM2_ENST00000426855.2_Missense_Mutation_p.D190N	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	190	RUN.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CAAGACAGCCGATCACTACTG	0.627000													5	303					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													8	178					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:29628278G>A	ENST00000278882.3	+	6	660	c.280G>A	c.(280-282)Gca>Aca	p.A94T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A94T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A99T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGCAATGAAGCAGGGGACAT	0.373000													9	437					0	0	1	0	0
CGB7	94027	broad.mit.edu	37	19	49558229	49558229	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:49558229T>C	ENST00000356213.4	-	4	2923	c.46A>G	c.(46-48)Aca>Gca	p.T16A	CGB7_ENST00000596965.1_Missense_Mutation_p.T18A|CGB7_ENST00000377280.3_Missense_Mutation_p.T18A|CGB7_ENST00000597853.1_Missense_Mutation_p.T18A					chorionic gonadotropin, beta polypeptide 7									p.T18A(1)		lung(3)|urinary_tract(2)	5		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GATGCCCATGTCCCGCCCATG	0.657000													7	466					0	0	1	0	0
RP11-261C10.3	0	broad.mit.edu	37	1	243251439	243251439	+	RNA	SNP	T	T	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:243251439T>A	ENST00000417964.1	-	0	663																											aaaaaaaaaaTTCCTTTGGGA	0.458000													5	11					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32957064	32957064	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:32957064G>A	ENST00000321639.5	+	6	1434	c.1106G>A	c.(1105-1107)cGg>cAg	p.R369Q		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	369						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CTGACTGGCCGGACAGTGGCC	0.577000													4	176					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285638	16285638	+	Silent	SNP	G	G	A	rs144617200		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:16285638G>A	ENST00000302182.3	+	2	809	c.417G>A	c.(415-417)aaG>aaA	p.K139K	UBB_ENST00000395837.1_Silent_p.K139K|UBB_ENST00000578649.1_Intron|UBB_ENST00000395839.1_Silent_p.K139K|UBB_ENST00000535788.1_Intron|RP11-138I1.4_ENST00000583934.1_RNA	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	139	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		ACATCCAGAAGGAGTCGACCC	0.567000													7	504					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1266204	1266204	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:1266204G>A	ENST00000447027.1	+	31	8161	c.8103G>A	c.(8101-8103)acG>acA	p.T2701T	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.T2698T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2698	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ctacgatcacggccaccggct	0.622000													3	32					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1921002	1921002	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:1921002C>T	ENST00000399161.2	-	11	2340	c.1593G>A	c.(1591-1593)ccG>ccA	p.P531P	MYT1L_ENST00000428368.2_Silent_p.P529P	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	531					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P531P(2)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TATCTTTGTGCGGGCATCCGG	0.562000													7	879					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								6	298					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952583	54952583	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:54952583G>A	ENST00000273286.5	-	3	1103	c.941C>T	c.(940-942)gCg>gTg	p.A314V	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000490478.1_Intron|CACNA2D3_ENST00000474759.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.A238V|CACNA2D3_ENST00000288197.5_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	314						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TGTGATTGCCGCATAGGTGCA	0.532000													7	807					0	0	1	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137089489	137089489	+	Silent	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:137089489C>A	ENST00000314940.4	-	1	550	c.267G>T	c.(265-267)gcG>gcT	p.A89A		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	89					nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CACCGGGCCGCGCCGAATCCT	0.657000													11	537					6.40141e-05	6.58431e-05	1	1	0
DPY19L2P1	0	broad.mit.edu	37	7	35131480	35131480	+	RNA	SNP	A	A	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:35131480A>T	ENST00000436258.1	-	0	1889																											ATCTTCGTAAAGTGGATGATT	0.423000													6	351					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62340496	62340496	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:62340496C>T	ENST00000328969.5	+	2	691	c.564C>T	c.(562-564)tgC>tgT	p.C188C	ZGPAT_ENST00000355969.6_Silent_p.C188C|ZGPAT_ENST00000448100.1_Silent_p.C188C|ZGPAT_ENST00000357119.4_Silent_p.C188C|ZGPAT_ENST00000369967.3_Silent_p.C188C|ZGPAT_ENST00000490623.1_3'UTR	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	188				C -> R (in Ref. 3; BAC11317).	negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					AGGGAAAGTGCCGCTTTAAGG	0.602000													6	543					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24702713	24702713	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:24702713G>A	ENST00000557854.1	+	2	447	c.170G>A	c.(169-171)cGg>cAg	p.R57Q	GMPR2_ENST00000399440.2_Missense_Mutation_p.R39Q|GMPR2_ENST00000559104.1_Missense_Mutation_p.R57Q|GMPR2_ENST00000559836.1_Missense_Mutation_p.R39Q|GMPR2_ENST00000559910.1_Missense_Mutation_p.R39Q|GMPR2_ENST00000420554.2_Missense_Mutation_p.R57Q|GMPR2_ENST00000456667.3_Missense_Mutation_p.R39Q|GMPR2_ENST00000355299.4_Missense_Mutation_p.R39Q|GMPR2_ENST00000348719.7_Missense_Mutation_p.R39Q			Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	39					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		TTTTCATTTCGGAACTCAAAG	0.438000													5	516					0	0	1	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137089488	137089488	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:137089488G>A	ENST00000314940.4	-	1	551	c.268C>T	c.(268-270)Cgg>Tgg	p.R90W		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	90					nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCACCGGGCCGCGCCGAATCC	0.657000													12	529					0	0	1	0	0
MEPCE	56257	broad.mit.edu	37	7	100028454	100028454	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:100028454G>C	ENST00000310512.2	+	1	1201	c.813G>C	c.(811-813)caG>caC	p.Q271H	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	271							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCACCACCAGCAGCAGCAGG	0.647000													6	978					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141051740	141051740	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:141051740G>A	ENST00000239440.4	-	10	1579	c.1514C>T	c.(1513-1515)gCg>gTg	p.A505V	ARAP3_ENST00000508305.1_Missense_Mutation_p.A427V|ARAP3_ENST00000513878.1_Missense_Mutation_p.A167V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	505	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCCACAGTCCGCACACTGCCG	0.612000													7	1326					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000429426.2_Silent_p.S152S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								5	295					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55247756	55247756	+	Splice_Site	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:55247756C>A	ENST00000381298.2	-	13	2012		c.e13+1		IL6ST_ENST00000381294.3_Splice_Site|IL6ST_ENST00000536319.1_Splice_Site|IL6ST_ENST00000522633.2_Splice_Site|IL6ST_ENST00000336909.5_Splice_Site|IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000381286.3_Intron|IL6ST_ENST00000502326.3_Splice_Site|IL6ST_ENST00000381287.4_Splice_Site	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)						interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AGTTTTATTACCAGTTTCATT	0.289000			O		hepatocellular ca								45	91					1.00001e-27	1.07785e-27	1	1	0
SLC18A3	6572	broad.mit.edu	37	10	50819229	50819229	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:50819229G>A	ENST00000374115.3	+	1	883	c.443G>A	c.(442-444)cGc>cAc	p.R148H	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	148					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TTCATCGACCGCATGAGCTAC	0.617000													7	746					0	0	1	0	0
PSMD2	5708	broad.mit.edu	37	3	184021144	184021144	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:184021144G>A	ENST00000310118.4	+	9	1664	c.1106G>A	c.(1105-1107)cGc>cAc	p.R369H	EIF2B5_ENST00000444495.1_Intron|PSMD2_ENST00000439383.1_Missense_Mutation_p.R239H|PSMD2_ENST00000435761.1_Missense_Mutation_p.R210H	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	369					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GACTCTGCCCGCATGAACCTG	0.493000													9	1060					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	211215	211215	+	Nonsense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr18:211215G>A	ENST00000261601.6	+	16	1507	c.1416G>A	c.(1414-1416)tgG>tgA	p.W472*	USP14_ENST00000582707.1_Nonsense_Mutation_p.W437*|USP14_ENST00000383589.2_Nonsense_Mutation_p.W426*|USP14_ENST00000400266.3_Nonsense_Mutation_p.W461*	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	472					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				GTGGAGACTGGCATATCGCTT	0.393000													5	458					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													5	106					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82387941	82387941	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:82387941T>C	ENST00000333891.8	-	25	15716	c.15379A>G	c.(15379-15381)Aga>Gga	p.R5127G		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	5050					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGACTATTCTTTTTCTGAGA	0.383000													6	962					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													4	88					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67432919	67432919	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:67432919G>A	ENST00000349015.3	-	7	981	c.543C>T	c.(541-543)ccC>ccT	p.P181P	ALDH3B2_ENST00000530069.1_Silent_p.P181P	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	181					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TCTGCAGGGCGGGCAGCAGCC	0.642000													6	736					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102783700	102783700	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:102783700C>T	ENST00000504592.1	+	8	1015	c.597C>T	c.(595-597)ttC>ttT	p.F199F	BANK1_ENST00000508653.1_Silent_p.F81F|BANK1_ENST00000444316.2_Silent_p.F184F|BANK1_ENST00000322953.4_Silent_p.F214F|BANK1_ENST00000428908.1_Silent_p.F81F			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	214					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GTGAAATATTCATAATTTTGA	0.318000													27	234					0	0	1	0	0
ORMDL3	94103	broad.mit.edu	37	17	38079367	38079367	+	Silent	SNP	C	C	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:38079367C>A	ENST00000394169.1	-	5	1818	c.324G>T	c.(322-324)gtG>gtT	p.V108V	ORMDL3_ENST00000584220.1_Silent_p.V92V|ORMDL3_ENST00000304046.2_Silent_p.V108V|ORMDL3_ENST00000579695.1_Silent_p.V108V			Q8N138	ORML3_HUMAN	ORM1-like 3 (S. cerevisiae)	108					ceramide metabolic process	integral to membrane|SPOTS complex	protein binding			endometrium(3)|kidney(1)|lung(1)	5	Colorectal(19;0.000442)		Lung(15;0.0234)			GCACTCACAGCACGATGGGTG	0.617000													25	530					1.37878e-21	1.46852e-21	1	1	0
WRN	7486	broad.mit.edu	37	8	30945390	30945390	+	Missense_Mutation	SNP	A	A	T	rs149565907	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr8:30945390A>T	ENST00000298139.5	+	12	1779	c.1530A>T	c.(1528-1530)gaA>gaT	p.E510D		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	510	Poly-Glu.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		aagaagaagaagatgatgaaa	0.373000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				5	330					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134218478	134218478	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:134218478C>T	ENST00000305233.5	+	2	533	c.474C>T	c.(472-474)aaC>aaT	p.N158N	PWWP2B_ENST00000368609.4_Silent_p.N158N	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	158										central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		TGTCCCGCAACCGCGACCCGG	0.721000													5	65					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902301	1902301	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:1902301G>A	ENST00000358771.4	+	3	849	c.697G>A	c.(697-699)Gtc>Atc	p.V233I	SIRPA_ENST00000400068.3_Missense_Mutation_p.V233I|SIRPA_ENST00000356025.3_Missense_Mutation_p.V233I	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	233	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V233I(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGTGGCCCACGTCACCTTGCA	0.617000													6	311					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713629	183713629	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:183713629T>C	ENST00000511685.1	+	26	5927	c.5804T>C	c.(5803-5805)cTa>cCa	p.L1935P	TENM3_ENST00000406950.2_Missense_Mutation_p.L1935P					teneurin transmembrane protein 3																		GGGCTGCTTCTACAAACAGCT	0.463000													6	462					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319016	70319016	+	Silent	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:70319016T>C	ENST00000338508.4	-	33	5510	c.5511A>G	c.(5509-5511)agA>agG	p.R1837R	SHANK2_ENST00000449833.2_Silent_p.R1241R|SHANK2_ENST00000409161.1_Silent_p.R1240R|SHANK2_ENST00000423696.2_Silent_p.R1457R			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1457					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTATGTTCATTCTGTGCCCGA	0.502000													8	851					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107827554	107827554	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:107827554C>T	ENST00000317357.5	+	3	1003	c.344C>T	c.(343-345)cCt>cTt	p.P115L		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	115							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		AGTGACTCACCTGCAGGGTCA	0.448000													8	967					0	0	1	0	0
C2	717	broad.mit.edu	37	6	31901955	31901955	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:31901955G>A	ENST00000299367.5	+	6	1004	c.728G>A	c.(727-729)cGt>cAt	p.R243H	CFB_ENST00000477310.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.R243H|CFB_ENST00000556679.1_Intron|C2_ENST00000469372.1_Intron|C2_ENST00000452323.2_Intron|CFB_ENST00000456570.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.R111H	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		AGCCTGGGCCGTAAAATCCAA	0.547000													6	872					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74640687	74640687	+	Silent	SNP	T	T	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:74640687T>C	ENST00000422840.2	-	1	305	c.306A>G	c.(304-306)ggA>ggG	p.G102G	GLG1_ENST00000205061.5_Silent_p.G102G|GLG1_ENST00000447066.2_Silent_p.G102G	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	102						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						CCCCCGCTCCTCCCCGCCGGG	0.697000													10	61					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49059989	49059989	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:49059989G>A	ENST00000262013.7	-	25	3341	c.3133C>T	c.(3133-3135)Cgg>Tgg	p.R1045W	SPAG9_ENST00000357122.4_Missense_Mutation_p.R1031W|SPAG9_ENST00000505279.1_Missense_Mutation_p.R1035W|SPAG9_ENST00000510283.1_Missense_Mutation_p.R888W	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	1045					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TGATGAGGCCGTCCAAGGTCT	0.398000													8	705					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	93225857	93225857	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:93225857C>T	ENST00000282020.4	+	1	308	c.50C>T	c.(49-51)aCc>aTc	p.T17I	GRID2_ENST00000505687.1_3'UTR|GRID2_ENST00000510992.1_Missense_Mutation_p.T17I	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	17					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGTCTCGAACCTGGGACTCG	0.458000													5	298					0	0	1	0	0
HSF4	3299	broad.mit.edu	37	16	67199662	67199662	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:67199662G>A	ENST00000264009.8	+	5	1238	c.273G>A	c.(271-273)ctG>ctA	p.L91L	HSF4_ENST00000521374.1_Silent_p.L91L|RP11-5A19.5_ENST00000518753.1_3'UTR|HSF4_ENST00000421453.1_Silent_p.L91L|HSF4_ENST00000584272.1_Silent_p.L91L|RP11-5A19.5_ENST00000580114.1_3'UTR	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4	91					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		AGGGCGGCCTGCTTAGGCCGG	0.726000													8	146					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72840498	72840498	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:72840498C>T	ENST00000293190.5	-	12	2646	c.2500G>A	c.(2500-2502)Gcc>Acc	p.A834T	GRIN2C_ENST00000347612.4_Missense_Mutation_p.A834T	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	834					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGCTCCCAGGCGAAGACCAGC	0.617000													6	471					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													6	546					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23530745	23530745	+	Silent	SNP	T	T	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:23530745T>G	ENST00000262710.1	-	17	3687	c.3360A>C	c.(3358-3360)ccA>ccC	p.P1120P	ACIN1_ENST00000555053.1_Silent_p.P1107P|ACIN1_ENST00000338631.6_Silent_p.P393P|ACIN1_ENST00000457657.1_Silent_p.P1080P|ACIN1_ENST00000605057.1_Silent_p.P1062P|ACIN1_ENST00000357481.2_Silent_p.P362P|ACIN1_ENST00000557515.1_Silent_p.P361P|ACIN1_ENST00000397341.3_Silent_p.P362P	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1120	Pro-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGGGTGGGGGTGGGGGGTGCA	0.657000													7	92					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12389931	12389931	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:12389931C>T	ENST00000358136.3	+	37	8373	c.8243C>T	c.(8242-8244)gCc>gTc	p.A2748V	VPS13D_ENST00000356315.4_Missense_Mutation_p.A2748V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2748					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAAGGCTATGCCCACTTCACC	0.418000													5	392					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44832738	44832738	+	Silent	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:44832738G>A	ENST00000354340.4	-	4	1623	c.1572C>T	c.(1570-1572)tgC>tgT	p.C524C	ZNF112_ENST00000536500.1_Silent_p.C547C|ZNF112_ENST00000337401.4_Silent_p.C530C	NM_013380.3	NP_037512.3			zinc finger protein 112																		AACCTTTGCCGCATATATTGC	0.423000													8	900					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716939	13716939	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:13716939G>A	ENST00000279593.3	-	13	3442	c.3233C>T	c.(3232-3234)gCc>gTc	p.A1078V		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1078					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACGCCTCTTGGCGGCATTGCC	0.592000													9	200					0	0	1	0	0
ITGB1BP1	9270	broad.mit.edu	37	2	9558813	9558813	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:9558813C>T	ENST00000360635.3	-	3	910	c.14G>A	c.(13-15)gGc>gAc	p.G5D	ITGB1BP1_ENST00000355346.4_Missense_Mutation_p.G5D|ITGB1BP1_ENST00000238091.4_Missense_Mutation_p.G5D|ITGB1BP1_ENST00000490426.1_Intron|ITGB1BP1_ENST00000488451.1_Missense_Mutation_p.G5D|ITGB1BP1_ENST00000456913.2_Missense_Mutation_p.G5D|ITGB1BP1_ENST00000359712.3_Missense_Mutation_p.G5D			O14713	ITBP1_HUMAN	integrin beta 1 binding protein 1	5					cell migration|cell-matrix adhesion|intracellular protein kinase cascade	cytosol|lamellipodium|membrane|ruffle	protein binding	p.G5D(1)		kidney(2)|large_intestine(2)|lung(2)|prostate(2)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.23)		TCGTTTTTTGCCCTTGCGAAA	0.393000													7	1000					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130699432	130699432	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:130699432G>A	ENST00000510168.1	+	20	2298	c.1748G>A	c.(1747-1749)cGt>cAt	p.R583H	ATP2C1_ENST00000328560.8_Missense_Mutation_p.R583H|ATP2C1_ENST00000422190.2_Missense_Mutation_p.R583H|ATP2C1_ENST00000359644.3_Missense_Mutation_p.R583H|ATP2C1_ENST00000393221.4_Missense_Mutation_p.R617H|ATP2C1_ENST00000428331.2_Missense_Mutation_p.R583H|ATP2C1_ENST00000504948.1_Missense_Mutation_p.R567H|ATP2C1_ENST00000504381.1_Missense_Mutation_p.R528H|ATP2C1_ENST00000533801.2_Missense_Mutation_p.R578H|ATP2C1_ENST00000513801.1_Missense_Mutation_p.R567H|ATP2C1_ENST00000508532.1_Missense_Mutation_p.R583H|ATP2C1_ENST00000507488.2_Missense_Mutation_p.R567H|ATP2C1_ENST00000505330.1_Missense_Mutation_p.R567H			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	583					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTAGCCAGTCGTCTGGGATTG	0.383000									Hailey-Hailey disease				7	286					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85982168	85982168	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:85982168G>T	ENST00000372113.4	-	3	1166	c.1161C>A	c.(1159-1161)gaC>gaA	p.D387E	LRIT2_ENST00000538192.1_Missense_Mutation_p.D397E	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	387	Fibronectin type-III.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CCTTAGAGGTGTCAGCCACTG	0.527000													6	283					3.09899e-07	3.22438e-07	1	1	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000583708.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													6	310					0.00198382	0.00200611	1	1	0
KLK15	55554	broad.mit.edu	37	19	51330936	51330936	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:51330936G>A	ENST00000326856.4	-	3	305	c.176C>T	c.(175-177)gCg>gTg	p.A59V	KLK15_ENST00000596931.1_Missense_Mutation_p.A59V|KLK15_ENST00000301421.2_Missense_Mutation_p.A60V|KLK15_ENST00000416184.1_Missense_Mutation_p.A60V|KLK15_ENST00000598239.1_Missense_Mutation_p.A60V	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	60	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GCAGTGGGCCGCAGACAGCAC	0.627000													4	162					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42656112	42656112	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:42656112G>A	ENST00000372901.1	+	45	5270	c.5012G>A	c.(5011-5013)gGc>gAc	p.G1671D	UBR2_ENST00000372883.3_3'UTR|UBR2_ENST00000372899.1_Missense_Mutation_p.G1671D			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1671					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TCTGGAGTGGGCATCTTCCTG	0.527000													6	728					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57111688	57111688	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:57111688A>G	ENST00000454682.1	-	3	3907	c.3626T>C	c.(3625-3627)cTa>cCa	p.L1209P	NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGGTAGCTAGACCTCCTTT	0.637000			T	BCL6	NHL								6	700					0	0	1	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383275	39383275	+	Silent	SNP	C	C	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:39383275C>G	ENST00000377721.3	+	1	376	c.369C>G	c.(367-369)ccC>ccG	p.P123P	KRTAP9-2_ENST00000455970.2_Silent_p.P107P	NM_031961.2	NP_114167.2	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9-2	123	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			large_intestine(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCTACTACCCCACGACTGTCT	0.627000													8	741					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43529791	43529791	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr21:43529791G>A	ENST00000400427.1	+	10	1819	c.1423G>A	c.(1423-1425)Gca>Aca	p.A475T	UMODL1_ENST00000400424.1_Missense_Mutation_p.A475T|UMODL1_ENST00000408989.2_Missense_Mutation_p.A547T|UMODL1_ENST00000408910.2_Missense_Mutation_p.A547T	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	547	SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CCCCTCCCGCGCAGGCCGGGC	0.677000													5	220					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122303575	122303575	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:122303575A>C	ENST00000334010.7	-	3	923	c.502T>G	c.(502-504)Tgt>Ggt	p.C168G	CADPS2_ENST00000412584.2_Missense_Mutation_p.C168G|CADPS2_ENST00000313070.7_Missense_Mutation_p.C168G|CADPS2_ENST00000449022.2_Missense_Mutation_p.C168G	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	168					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding	p.C168G(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TTAGCAGAACACCCTCCACTC	0.373000													11	95					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050124	164050124	+	Silent	SNP	T	T	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:164050124T>G	ENST00000274054.2	-	8	1603	c.1410A>C	c.(1408-1410)ccA>ccC	p.P470P	NAF1_ENST00000509434.1_Intron|NAF1_ENST00000422287.2_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	470	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				ggggagggggtgggggtaggg	0.522000													4	69					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651423	1651423	+	Missense_Mutation	SNP	G	G	C	rs76164438		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:1651423G>C	ENST00000399676.2	+	1	391	c.353G>C	c.(352-354)gGc>gCc	p.G118A		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	118	8 X 4 AA repeats of C-C-X-P.			Missing (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament		p.G118A(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TCCAAGGGGGGCTGTGGCTCC	0.701000													6	227					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187074872	187074872	+	Missense_Mutation	SNP	G	G	A	rs140771382		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:187074872G>A	ENST00000356371.5	+	5	1033	c.1033G>A	c.(1033-1035)Gca>Aca	p.A345T	FAM149A_ENST00000503432.1_Missense_Mutation_p.A54T|FAM149A_ENST00000389354.5_Missense_Mutation_p.A54T|FAM149A_ENST00000502970.1_Missense_Mutation_p.A54T|FAM149A_ENST00000227065.4_Missense_Mutation_p.A54T|FAM149A_ENST00000514829.1_3'UTR|FAM149A_ENST00000514153.1_Missense_Mutation_p.A54T			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	345										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCCTGCCTCCGCAGTCCACAG	0.507000													6	878					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917842	2917842	+	Missense_Mutation	SNP	G	G	A	rs149690257	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:2917842G>A	ENST00000306908.5	+	4	1371	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	ZNF57_ENST00000523428.1_Missense_Mutation_p.R376Q|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATCATTCCGAGGTCATTTG	0.428000													6	545					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53524146	53524146	+	Silent	SNP	C	C	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:53524146C>T	ENST00000262133.6	+	22	3491	c.3354C>T	c.(3352-3354)tgC>tgT	p.C1118C	RBL2_ENST00000544545.1_Silent_p.C497C|RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1118					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AAAGAATTTGCCCAGAAAATC	0.388000													5	425					0	0	1	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316570	39316570	+	Missense_Mutation	SNP	T	T	C	rs111563615		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:39316570T>C	ENST00000390661.3	-	1	413	c.374A>G	c.(373-375)tAc>tGc	p.Y125C		NM_032524.1	NP_115913.1	Q9BYR3	KRA44_HUMAN	keratin associated protein 4-4	125	26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].					keratin filament				kidney(1)|large_intestine(1)|lung(5)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GGACACACAGTAGCTGGGGCA	0.667000													10	401					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000537089.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													11	374					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53875859	53875859	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:53875859G>A	ENST00000267079.2	-	14	2572	c.2347C>T	c.(2347-2349)Cgg>Tgg	p.R783W	MAP3K12_ENST00000547488.1_Missense_Mutation_p.R816W|MAP3K12_ENST00000547035.1_Missense_Mutation_p.R816W	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	783					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						TCATCTGGCCGCTCATCAGTG	0.577000											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	583					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47315978	47315978	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:47315978G>A	ENST00000389798.3	+	19	2379	c.2182G>A	c.(2182-2184)Gca>Aca	p.A728T	LRCH1_ENST00000389797.3_Missense_Mutation_p.A763T|LRCH1_ENST00000311191.6_Intron	NM_015116.2	NP_055931.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	728										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TGCTCTGTCCGCATAATGTCT	0.502000													6	872					0	0	1	0	0
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:7838212_7838214delTCA	ENST00000054666.6	+	4	381_383	c.266_268delTCA	c.(265-270)ttc>t	p.FI89del	VAMP3_ENST00000470357.1_In_Frame_Del_p.FI61del	NM_004781.3	NP_004772.1	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	89					cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													8	756	---	---	---	---					
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:22838561_22838563delAAG	ENST00000404138.1	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)del	p.K803del	ZBTB40_ENST00000374651.4_In_Frame_Del_p.K691del|ZBTB40_ENST00000375647.4_In_Frame_Del_p.K803del	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													11	437	---	---	---	---					
MACF1	23499	broad.mit.edu	37	1	39799059	39799060	+	Frame_Shift_Ins	INS	-	-	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:39799059_39799060insG	ENST00000564288.1	+	37	7576_7577	c.6799_6800insG	c.(6799-6801)ggafs	p.G2267fs	MACF1_ENST00000317713.7_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000289893.4_Frame_Shift_Ins_p.G707fs|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000372915.3_Frame_Shift_Ins_p.G2272fs|MACF1_ENST00000567887.1_Frame_Shift_Ins_p.G2304fs|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000476350.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2272					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATAGTGGCAGGGAAATTTTT	0.391													8	461	---	---	---	---					
IPP	3652	broad.mit.edu	37	1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:46184897_46184898delAC	ENST00000396478.3	-	6	1265_1266	c.1163_1164delGT	c.(1162-1164)tfs	p.C388fs		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													10	332	---	---	---	---					
ST6GALNAC5	81849	broad.mit.edu	37	1	77334277	77334279	+	In_Frame_Del	DEL	GCA	GCA	-	rs113832855		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:77334277_77334279delGCA	ENST00000477717.1	+	2	346_348	c.111_113delGCA	c.(109-114)ccg>cc	p.PQ37del	ST6GALNAC5_ENST00000496845.1_3'UTR	NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	37					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						AGCGGCCCCCgcagcagcagcag	0.700													8	324	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115469133	115469134	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:115469133_115469134insA	ENST00000369522.3	+	23	2115_2116	c.1875_1876insA	c.(1873-1878)ttaaaafs	p.LK625fs	SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.LK625fs	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	625					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAAGGCCTTGAAAAAAAAAGG	0.267													8	185	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2892)aaafs	p.K964fs	SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.K964fs|SYCP1_ENST00000477590.1_3'UTR	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													18	352	---	---	---	---					
ANKRD20A12P	0	broad.mit.edu	37	1	142716575	142716578	+	RNA	DEL	AAAC	AAAC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:142716575_142716578delAAAC	ENST00000595144.1	-	0	418																											catctcagaaaaacaaacaaacaa	0.422													10	425	---	---	---	---					
ANKRD20A12P	0	broad.mit.edu	37	1	142720897	142720898	+	RNA	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:142720897_142720898insA	ENST00000595144.1	-	0	204_205																											GCTCTTCCTCTAAGCCACTGGT	0.277													14	137	---	---	---	---					
HFE2	148738	broad.mit.edu	37	1	145415369	145415371	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:145415369_145415371delGAG	ENST00000336751.5	+	3	426_428	c.188_190delGAG	c.(187-192)cga>c	p.RG63del	HFE2_ENST00000475797.1_Intron|HFE2_ENST00000357836.5_5'UTR|HFE2_ENST00000497365.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	63					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCACTTCGAGGAGGAGGAGG	0.626													7	374	---	---	---	---					
LINGO4	339398	broad.mit.edu	37	1	151773603	151773603	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:151773603delA	ENST00000368820.3	-	2	2515	c.1578delT	c.(1576-1578)ttfs	p.F526fs		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	526						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCTATCCAGAAAAAAAGGCC	0.582													7	1168	---	---	---	---					
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	TG	-	rs140875805	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:152324558_152324559delTG	ENST00000388718.5	-	3	5775_5776	c.5703_5704delCA	c.(5701-5706)cagcfs	p.HS1901fs	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													11	1283	---	---	---	---					
LCE4A	199834	broad.mit.edu	37	1	152681680	152681681	+	In_Frame_Ins	INS	-	-	AGCTCTGGGGGCTGCTGT	rs6143428	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr1:152681680_152681681insAGCTCTGGGGGCTGCTGT	ENST00000368777.1	+	2	385_386	c.129_130insAGCTCTGGGGGCTGCTGT	c.(127-132)tcgctc>tcAGCTCTGGGGGCTGCTGTgctc	p.43_44SL>SALGAAVL	LCE4A_ENST00000335535.3_In_Frame_Ins_p.43_44SL>SALGAAVL			Q5TA78	LCE4A_HUMAN	late cornified envelope 4A	43	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)			GCTGTGGCTCCAGCTCTGGGGG	0.599													7	626	---	---	---	---					
SMC6	79677	broad.mit.edu	37	2	17898126	17898126	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:17898126delT	ENST00000448223.2	-	14	1497	c.1228delA	c.(1228-1230)tafs	p.I410fs	SMC6_ENST00000351948.4_Frame_Shift_Del_p.I410fs|SMC6_ENST00000402989.1_Frame_Shift_Del_p.I410fs|SMC6_ENST00000381272.4_Frame_Shift_Del_p.I436fs	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	410					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AACCAAGATATTTTTTTTTGT	0.343													13	329	---	---	---	---					
PUM2	23369	broad.mit.edu	37	2	20482977	20482979	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:20482977_20482979delGCT	ENST00000361078.2	-	11	1471_1473	c.1449_1451delAGC	c.(1447-1452)gct>gc	p.AA483del	PUM2_ENST00000403432.1_In_Frame_Del_p.AA483del|PUM2_ENST00000338086.5_In_Frame_Del_p.AA483del|PUM2_ENST00000319801.5_In_Frame_Del_p.AA483del|PUM2_ENST00000536417.1_In_Frame_Del_p.AA427del			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	483	Ala-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTCCTCCAGCTGCTGCTGCTG	0.424													8	443	---	---	---	---					
HS1BP3	64342	broad.mit.edu	37	2	20840864	20840864	+	Frame_Shift_Del	DEL	G	G	-	rs77941615	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:20840864delG	ENST00000402541.1	-	3	289	c.275delC	c.(274-276)cafs	p.P92fs	HS1BP3_ENST00000304031.3_Frame_Shift_Del_p.P92fs|HS1BP3_ENST00000406618.3_Frame_Shift_Del_p.P92fs			Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	92	PX.				cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGGGTAGTGGGGGGAGGCT	0.537													8	1270	---	---	---	---					
RTN4	57142	broad.mit.edu	37	2	55253745	55253746	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:55253745_55253746insT	ENST00000337526.6	-	3	1732_1733	c.1489_1490insA	c.(1489-1491)agafs	p.R497fs	RTN4_ENST00000404909.1_Frame_Shift_Ins_p.R291fs|RTN4_ENST00000357376.3_Frame_Shift_Ins_p.R291fs|RTN4_ENST00000402434.2_Intron|RTN4_ENST00000357732.4_Intron|RTN4_ENST00000405240.1_Frame_Shift_Ins_p.R291fs|RTN4_ENST00000354474.6_Frame_Shift_Ins_p.R265fs|RTN4_ENST00000317610.7_Intron|RTN4_ENST00000394611.2_Frame_Shift_Ins_p.R291fs	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	497					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						CTTTTCTTCTATTTTTTTTTCA	0.381													8	481	---	---	---	---					
DUSP2	1844	broad.mit.edu	37	2	96809973	96809973	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:96809973delA	ENST00000288943.4	-	3	735	c.650delT	c.(649-651)tcfs	p.F217fs		NM_004418.3	NP_004409.1	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	217					endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			NS(1)|breast(1)|lung(2)|skin(1)	5		Ovarian(717;0.0228)				CTTGTAGCGGAAAAGGCCCTC	0.602													7	642	---	---	---	---					
SLC9A4	389015	broad.mit.edu	37	2	103149137	103149137	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:103149137delA	ENST00000295269.4	+	12	2844	c.2387delA	c.(2386-2388)cafs	p.Q796fs		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	796					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CCTTTGCTCCAAAAAAAATAG	0.473													11	267	---	---	---	---					
IFIH1	64135	broad.mit.edu	37	2	163134715	163134716	+	Splice_Site	INS	-	-	T	rs150760072		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:163134715_163134716insT	ENST00000263642.2	-	9	2159_2160	c.1765_splice	c.e9+1	p.NC588_splice		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	588					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						CCTAAATTACCTTTTTTTTCCA	0.327													7	485	---	---	---	---					
HIBCH	26275	broad.mit.edu	37	2	191161629	191161629	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:191161629delT	ENST00000392332.3	-	3	268	c.129delA	c.(127-129)aafs	p.K43fs	HIBCH_ENST00000359678.5_Frame_Shift_Del_p.K43fs			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	43					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CCGTGCAACCTTTTTTTTCCA	0.353													8	362	---	---	---	---					
AC010136.2	0	broad.mit.edu	37	2	218847717	218847717	+	RNA	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr2:218847717delC	ENST00000450996.1	+	0	138																											CCCCCCACCACCAATGCCACC	0.512													2	4	---	---	---	---					
LRIG1	26018	broad.mit.edu	37	3	66436625	66436627	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:66436625_66436627delGCT	ENST00000383703.3	-	14	2242_2244	c.1639_1641delAGC	c.(1639-1641)del	p.S548del	LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_In_Frame_Del_p.S524del|SLC25A26_ENST00000536651.1_3'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	524	Ig-like C2-type 1.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TCATGGGGGAGCTGCTGCTGCTG	0.547													11	1636	---	---	---	---					
EAF2	55840	broad.mit.edu	37	3	121573658	121573659	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:121573658_121573659insA	ENST00000273668.2	+	3	397_398	c.326_327insA	c.(325-327)gaafs	p.E109fs	EAF2_ENST00000451944.2_Frame_Shift_Ins_p.E109fs	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	109					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		AACATCACTGTAAAAAAAACAA	0.248													7	621	---	---	---	---					
PDIA5	10954	broad.mit.edu	37	3	122869089	122869089	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:122869089delC	ENST00000316218.7	+	14	1246	c.1151delC	c.(1150-1152)gcfs	p.A384fs	PDIA5_ENST00000467157.1_3'UTR	NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	384	Thioredoxin 2.|Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		AGCCCTGAGGCCCCCCCGCCC	0.602													8	539	---	---	---	---					
TMCC1	23023	broad.mit.edu	37	3	129546680	129546682	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:129546680_129546682delGCA	ENST00000393238.3	-	3	880_882	c.540_542delTGC	c.(538-543)gca>gc	p.AA180del	TMCC1_ENST00000426664.2_In_Frame_Del_p.AA66del	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	180						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						TGGTAGACATgcagcagcagcag	0.483													10	477	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995077	146995077	+	RNA	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:146995077delA	ENST00000473299.1	-	0	132																											TCTGGACTGtaaaaaaaaaaa	0.294													8	27	---	---	---	---					
RP11-139K4.2	0	broad.mit.edu	37	3	182220015	182220016	+	RNA	DEL	AG	AG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr3:182220015_182220016delAG	ENST00000489016.1	-	0	461																											agggacagacagagagagagag	0.470													2	4	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													7	343	---	---	---	---					
PKD2	5311	broad.mit.edu	37	4	88986558	88986559	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:88986558_88986559insA	ENST00000237596.2	+	11	2217_2218	c.2151_2152insA	c.(2149-2154)ctaaaafs	p.LK717fs	PKD2_ENST00000508588.1_Frame_Shift_Ins_p.LK135fs|PKD2_ENST00000502363.1_Frame_Shift_Ins_p.LK135fs|PKD2_ENST00000511337.1_3'UTR	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	717	EF-hand domain.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		AACTAAAACTGAAAAAAAATAC	0.386													8	573	---	---	---	---					
HMGB2	3148	broad.mit.edu	37	4	174253277	174253279	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr4:174253277_174253279delTCC	ENST00000296503.5	-	5	1455_1457	c.582_584delGGA	c.(580-585)gaa>ga	p.EE196del	HMGB2_ENST00000438704.2_In_Frame_Del_p.EE196del|HMGB2_ENST00000446922.2_In_Frame_Del_p.EE196del			P26583	HMGB2_HUMAN	high mobility group box 2	196	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding	p.E194E(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		atcttcttcttcctcctcctcct	0.468													17	510	---	---	---	---					
BRD9	65980	broad.mit.edu	37	5	889776	889777	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:889776_889777insA	ENST00000323510.4	-	1	37_38	c.38_39insT	c.(37-39)tctfs	p.S13fs	BRD9_ENST00000388890.4_Frame_Shift_Ins_p.S13fs|BRD9_ENST00000483173.1_Intron|BRD9_ENST00000467963.1_Intron|BRD9_ENST00000435709.2_Frame_Shift_Ins_p.S13fs			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	0							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			ACAATTTAAGGAAAAAAAAATT	0.446													7	365	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:24492973delA	ENST00000264463.4	-	10	2084	c.1577delT	c.(1576-1578)tcfs	p.F526fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			10	1474	---	---	---	---					
AC026703.1	0	broad.mit.edu	37	5	32789822	32789823	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:32789822_32789823delGT	ENST00000326958.1	+	1	878_879	c.315_316delGT	c.(313-318)gggtfs	p.GC105fs	NPR3_ENST00000265074.8_3'UTR																							CTGATTTTGGGTGTGTGTGTGT	0.421													11	513	---	---	---	---					
CMYA5	202333	broad.mit.edu	37	5	79041149	79041151	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:79041149_79041151delGAA	ENST00000446378.2	+	4	10870_10872	c.10839_10841delGAA	c.(10837-10842)gtg>gt	p.VK3613del		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3613	B-box coiled-coil; BBC.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTGAGGAAGTGAAGAAGAAGAAG	0.448													8	295	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216457	149216459	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:149216457_149216459delGGA	ENST00000309241.5	+	8	2471_2473	c.2439_2441delGGA	c.(2437-2442)ggg>gg	p.GE813del	PPARGC1B_ENST00000403750.1_In_Frame_Del_p.GE749del|PPARGC1B_ENST00000394320.3_In_Frame_Del_p.GE813del|PPARGC1B_ENST00000360453.4_In_Frame_Del_p.GE774del	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	813	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			aggaagaaggggaggaggaggag	0.606													8	462	---	---	---	---					
UNC5A	90249	broad.mit.edu	37	5	176301302	176301304	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr5:176301302_176301304delCAC	ENST00000329542.4	+	8	1387_1389	c.1113_1115delCAC	c.(1111-1116)agc>ag	p.ST371del	UNC5A_ENST00000261961.3_In_Frame_Del_p.ST331del	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	371					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGACCTCAGCACCACCACCACC	0.645													7	500	---	---	---	---					
GABBR1	0	broad.mit.edu	37	6	29573436	29573438	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:29573436_29573438delCAG	ENST00000377034.4	-	20	2682_2684	c.2347_2349delCTG	c.(2347-2349)del	p.L783del	GABBR1_ENST00000377012.4_In_Frame_Del_p.L666del|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000355973.3_In_Frame_Del_p.L666del|GABBR1_ENST00000377016.4_In_Frame_Del_p.L721del	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	783					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.L783M(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GGAAGATTCCCAGCAGCAGCAGC	0.512													10	620	---	---	---	---					
PPP1R10	5514	broad.mit.edu	37	6	30571900	30571900	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:30571900delG	ENST00000376511.2	-	14	1945	c.1393delC	c.(1393-1395)ggfs	p.R465fs		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	465	Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						ACCAGGGGCCGGGGGCACACC	0.582													7	1201	---	---	---	---					
CYP21A1P	0	broad.mit.edu	37	6	31975223	31975224	+	RNA	INS	-	-	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:31975223_31975224insT	ENST00000342991.6	+	0	1346_1347					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										CTGGGCCGTGGTTTTTTTTGCT	0.614													7	877	---	---	---	---					
TREML2	79865	broad.mit.edu	37	6	41168714	41168716	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:41168714_41168716delCAG	ENST00000483722.1	-	1	216_218	c.31_33delCTG	c.(31-33)del	p.L11del		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	11					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTGTGGCCACAGCAGCAGCAGC	0.631													10	171	---	---	---	---					
PHF3	23469	broad.mit.edu	37	6	64394097	64394097	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:64394097delA	ENST00000262043.3	+	4	814	c.474delA	c.(472-474)acfs	p.T158fs	PHF3_ENST00000509330.1_Frame_Shift_Del_p.T158fs|PHF3_ENST00000393387.1_Frame_Shift_Del_p.T158fs			Q92576	PHF3_HUMAN	PHD finger protein 3	158					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TAAGTAACACAAAAAAAGCAT	0.383													7	1074	---	---	---	---					
GABRR2	2570	broad.mit.edu	37	6	89975427	89975429	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:89975427_89975429delAAG	ENST00000402938.3	-	7	925_927	c.792_794delCTT	c.(790-795)ttg>tt	p.FL264del	GABRR2_ENST00000602399.1_In_Frame_Del_p.FL289del			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	289					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGTTTGGAGCAAGAAGAAGAAGA	0.517													8	359	---	---	---	---					
WISP3	8838	broad.mit.edu	37	6	112389434	112389434	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:112389434delA	ENST00000361714.1	+	4	715	c.670delA	c.(670-672)aafs	p.K226fs	WISP3_ENST00000604763.1_Frame_Shift_Del_p.K208fs|WISP3_ENST00000409166.1_5'UTR|WISP3_ENST00000230529.5_Frame_Shift_Del_p.K208fs|WISP3_ENST00000368663.3_Frame_Shift_Del_p.K185fs|WISP3_ENST00000368666.2_Frame_Shift_Del_p.K208fs			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	208	TSP type-1.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		ACTTATTTGGAAAAAAAAATG	0.333													9	271	---	---	---	---					
SOGA3	387104	broad.mit.edu	37	6	127804080	127804080	+	Frame_Shift_Del	DEL	T	T	-	rs34142169		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr6:127804080delT	ENST00000556132.1	-	5	2399	c.1535delA	c.(1534-1536)agfs	p.K512fs	SOGA3_ENST00000368268.2_Frame_Shift_Del_p.K512fs|SOGA3_ENST00000465909.2_Frame_Shift_Del_p.K512fs|SOGA3_ENST00000481848.2_Frame_Shift_Del_p.K512fs|SOGA3_ENST00000525778.1_Frame_Shift_Del_p.K512fs	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	512						integral to membrane											CTGTTGAGCCTTTTTTTCAGA	0.294													10	827	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91732038	91732039	+	Frame_Shift_Ins	INS	-	-	G	rs143306820		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:91732038_91732039insG	ENST00000359028.2	+	46	11465_11466	c.11240_11241insG	c.(11239-11241)aggfs	p.R3747fs	AKAP9_ENST00000356239.3_Frame_Shift_Ins_p.R3743fs|AKAP9_ENST00000358100.2_Frame_Shift_Ins_p.R3693fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3747					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTTGCCCGGATGGGGGGGCAGC	0.535			T	BRAF	papillary thyroid								8	1173	---	---	---	---					
WASL	8976	broad.mit.edu	37	7	123332873	123332875	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr7:123332873_123332875delGGA	ENST00000223023.4	-	9	1205_1207	c.873_875delTCC	c.(871-876)ccc>cc	p.PP293del		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	293	Pro-rich.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						gtgtggagggggaggaggaggag	0.567													8	480	---	---	---	---					
KAT6A	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr8:41798420_41798422delCTC	ENST00000396930.3	-	16	3520_3522	c.2977_2979delGAG	c.(2977-2979)del	p.E993del	KAT6A_ENST00000406337.1_In_Frame_Del_p.E993del|KAT6A_ENST00000265713.2_In_Frame_Del_p.E993del	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GGCTTTCCGGCTCCTCCTCCTCC	0.567													11	880	---	---	---	---					
SULF1	23213	broad.mit.edu	37	8	70514026	70514026	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr8:70514026delT	ENST00000260128.4	+	10	1740	c.1023delT	c.(1021-1023)ccfs	p.P341fs	SULF1_ENST00000419716.3_Frame_Shift_Del_p.P341fs|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000458141.2_Frame_Shift_Del_p.P341fs|SULF1_ENST00000402687.4_Frame_Shift_Del_p.P341fs	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	341					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTCGTGTGCCTTTTTTTATTC	0.408													7	1222	---	---	---	---					
DCAF13	25879	broad.mit.edu	37	8	104439486	104439487	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr8:104439486_104439487insT	ENST00000521971.1	+	4	590_591	c.510_511insT	c.(508-513)atttttfs	p.IF170fs	DCAF13_ENST00000519682.1_Frame_Shift_Ins_p.IF206fs|DCAF13_ENST00000521999.1_Intron|DCAF13_ENST00000297579.5_Intron			Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	0					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TTGAGGTAATGTTTTTTTTTAA	0.277													8	235	---	---	---	---					
MTSS1	9788	broad.mit.edu	37	8	125597329	125597329	+	Splice_Site	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr8:125597329delT	ENST00000518547.1	-	6	932	c.460_splice	c.e6+1	p.K153_splice	MTSS1_ENST00000378017.3_Splice_Site_p.K153_splice|MTSS1_ENST00000354184.4_5'UTR|MTSS1_ENST00000325064.5_Splice_Site_p.K153_splice	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	153	IMD.			K -> KVDTL (in Ref. 2; AK027015).	actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			AGGAGTTACCTTTTTTTGCTT	0.373													7	726	---	---	---	---					
SLC46A2	57864	broad.mit.edu	37	9	115652769	115652769	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr9:115652769delC	ENST00000374228.4	-	1	424	c.193delG	c.(193-195)ctfs	p.A65fs		NM_033051.3	NP_149040.3	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	65						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(1)	18						TCCTCTAGAGCCCCCCGGGGC	0.627													7	798	---	---	---	---					
SLC16A9	220963	broad.mit.edu	37	10	61414180	61414180	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:61414180delT	ENST00000395348.3	-	5	1240	c.604delA	c.(604-606)tafs	p.I202fs	SLC16A9_ENST00000395347.1_Frame_Shift_Del_p.I202fs	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	202					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						TCTGGAGCTATTTTTTTAGGC	0.378													7	746	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61828745	61828747	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:61828745_61828747delGTG	ENST00000280772.1	-	37	12083_12085	c.11892_11894delCAC	c.(11890-11895)act>ac	p.TT3964del	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3964	Thr-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ggtggtggcagtggtggtggtgg	0.498													8	629	---	---	---	---					
SCD	6319	broad.mit.edu	37	10	102107836	102107838	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr10:102107836_102107838delACC	ENST00000370355.2	+	2	424_426	c.43_45delACC	c.(43-45)del	p.T19del		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	19					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581													7	802	---	---	---	---					
AP2A2	161	broad.mit.edu	37	11	970195	970195	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:970195delA	ENST00000448903.2	+	3	304	c.163delA	c.(163-165)aafs	p.K57fs	AP2A2_ENST00000534328.1_Frame_Shift_Del_p.K57fs|AP2A2_ENST00000332231.5_Frame_Shift_Del_p.K57fs	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	57	Lipid-binding.				axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity	p.K57fs*24(1)		breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGCTATAGTAAAAAAAAGTA	0.488													7	692	---	---	---	---					
KCNA4	3739	broad.mit.edu	37	11	30034029	30034031	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:30034029_30034031delTGG	ENST00000328224.6	-	2	1428_1430	c.195_197delCCA	c.(193-198)cag>ca	p.HQ65del		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	65	Poly-His.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCGCGTGACTGGTGGTGGTGGT	0.660													7	467	---	---	---	---					
ATG16L2	89849	broad.mit.edu	37	11	72528863	72528865	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:72528863_72528865delAGG	ENST00000321297.5	+	3	419_421	c.281_283delAGG	c.(280-285)cag>c	p.QE94del	ATG16L2_ENST00000534905.1_In_Frame_Del_p.QE94del	NM_033388.1	NP_203746.1	Q8NAA4	A16L2_HUMAN	autophagy related 16-like 2 (S. cerevisiae)	94					autophagy|protein transport	cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	14			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			GTGAAGTGGCAGGAGGAGGAGGA	0.591													7	197	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89407177	89407177	+	RNA	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:89407177delC	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TTTTTTTTTTCCCCAATCTGG	0.303													7	180	---	---	---	---					
OR8D4	338662	broad.mit.edu	37	11	123777441	123777442	+	Frame_Shift_Ins	INS	-	-	T	rs79561639	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr11:123777441_123777442insT	ENST00000321355.2	+	1	333_334	c.303_304insT	c.(301-306)ctttttfs	p.LF101fs		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGATTCAGCTGTTTTTTTTCTG	0.436													16	1107	---	---	---	---					
LINC00987	0	broad.mit.edu	37	12	9392739	9392740	+	RNA	INS	-	-	TCTTCCTCCTCC	rs71045240		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:9392739_9392740insTCTTCCTCCTCC	ENST00000427111.3	+	0	141_142					NR_036466.1																						caccatcaccttcttcctcccc	0.545													8	116	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46318575	46318577	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:46318575_46318577delGGT	ENST00000465950.1	-	2	4104_4106	c.2895_2897delACC	c.(2893-2898)ccc>cc	p.PP969del	SCAF11_ENST00000549162.1_In_Frame_Del_p.PP1092del|SCAF11_ENST00000369367.3_In_Frame_Del_p.PP1284del|SCAF11_ENST00000419565.2_In_Frame_Del_p.PP1284del			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1284	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TGGGGGAGGGGGTGGTGGTGGTG	0.483													7	411	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													9	987	---	---	---	---					
GOLGA2B	0	broad.mit.edu	37	12	100551828	100551830	+	RNA	DEL	CCT	CCT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:100551828_100551830delCCT	ENST00000397112.4	-	0	1625_1627					NR_036632.1															large_intestine(1)|lung(3)	4						GGCTGAGGCACCTCCTCCTCCTC	0.635													7	134	---	---	---	---					
RASAL1	8437	broad.mit.edu	37	12	113565943	113565943	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:113565943delC	ENST00000546530.1	-	4	448	c.163delG	c.(163-165)agfs	p.E56fs	RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000261729.5_Frame_Shift_Del_p.E56fs|RASAL1_ENST00000548055.1_Frame_Shift_Del_p.E56fs|RASAL1_ENST00000446861.3_Frame_Shift_Del_p.E56fs	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	56	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GTGTACTCCTCCCCCCAGAAG	0.617													7	1483	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr12:121134166_121134168delGAA	ENST00000228506.3	+	5	1125_1127	c.697_699delGAA	c.(697-699)del	p.E238del	MLEC_ENST00000412616.2_In_Frame_Del_p.RK154del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	238	Poly-Glu.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding	p.E233E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gaaagaagaggaagaagaagaag	0.458													11	842	---	---	---	---					
TPTE2	93492	broad.mit.edu	37	13	20041394	20041394	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:20041394delA	ENST00000400230.2	-	7	527	c.483delT	c.(481-483)ttfs	p.F161fs	TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000382975.4_Intron|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382977.4_Frame_Shift_Del_p.F161fs|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000382978.1_Intron|TPTE2_ENST00000400103.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	161						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ACTTAATGTCAAAAAAAATGT	0.303													10	354	---	---	---	---					
SACS	26278	broad.mit.edu	37	13	23912864	23912864	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:23912864delT	ENST00000382298.3	-	10	5739	c.5151delA	c.(5149-5151)aafs	p.K1717fs	SACS_ENST00000402364.1_Frame_Shift_Del_p.K967fs|SACS_ENST00000382292.3_Frame_Shift_Del_p.K1717fs	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1717					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGAGCAGGATTTTTTTTTAA	0.358													10	316	---	---	---	---					
RFC3	5983	broad.mit.edu	37	13	34398063	34398063	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:34398063delA	ENST00000380071.3	+	3	365	c.235delA	c.(235-237)aafs	p.K81fs	RFC3_ENST00000434425.1_Frame_Shift_Del_p.K81fs	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	81					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		GACTCCATCTAAAAAAAAAAT	0.269													14	283	---	---	---	---					
SLITRK5	26050	broad.mit.edu	37	13	88329794	88329796	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr13:88329794_88329796delCGG	ENST00000325089.6	+	2	2370_2372	c.2151_2153delCGG	c.(2149-2154)tac>ta	p.YG717del	SLITRK5_ENST00000400028.3_In_Frame_Del_p.YG476del	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	717						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACAGCGTGTACGGCGGCGGCGGC	0.645													7	426	---	---	---	---					
APEX1	328	broad.mit.edu	37	14	20925506	20925506	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:20925506delT	ENST00000216714.3	+	5	1064	c.796delT	c.(796-798)ttfs	p.F266fs	APEX1_ENST00000398030.4_Frame_Shift_Del_p.F266fs|APEX1_ENST00000557054.1_3'UTR|APEX1_ENST00000555414.1_Frame_Shift_Del_p.F266fs	NM_001244249.1|NM_001641.3	NP_001231178.1|NP_001632.2	P27695	APEX1_HUMAN	APEX nuclease (multifunctional DNA repair enzyme) 1	266					base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	TGCCTACACCTTTTGGACTTA	0.502								Other BER factors					7	834	---	---	---	---					
SALL2	6297	broad.mit.edu	37	14	21991334	21991336	+	In_Frame_Del	DEL	GGT	GGT	-	rs113881459		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:21991334_21991336delGGT	ENST00000327430.3	-	2	2820_2822	c.2526_2528delACC	c.(2524-2529)cct>cc	p.PP842del	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_In_Frame_Del_p.PP705del	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	842	Poly-Pro.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CAGGCTGTCAGGTGGTGGTGGTG	0.571													7	540	---	---	---	---					
PCK2	5106	broad.mit.edu	37	14	24572757	24572757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:24572757delT	ENST00000545054.2	+	10	2023	c.1105delT	c.(1105-1107)ttfs	p.F370fs	PCK2_ENST00000559250.1_Intron|PCK2_ENST00000216780.4_Frame_Shift_Del_p.F504fs|PCK2_ENST00000561286.1_Frame_Shift_Del_p.F370fs|PCK2_ENST00000558096.1_Frame_Shift_Del_p.F338fs|NRL_ENST00000561028.1_Intron			Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	504					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			breast(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(265;0.0184)		CATGCGGCCCTTTTTTGGCTA	0.577													7	588	---	---	---	---					
RALGAPA1	253959	broad.mit.edu	37	14	36194270	36194270	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:36194270delT	ENST00000258840.6	-	14	2216	c.1826delA	c.(1825-1827)atfs	p.N609fs	RALGAPA1_ENST00000307138.6_Frame_Shift_Del_p.N609fs|RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000382366.3_Frame_Shift_Del_p.N609fs|RALGAPA1_ENST00000389698.3_Frame_Shift_Del_p.N609fs			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	609					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAAGGTCATATTTTTTTTCCC	0.378													9	702	---	---	---	---					
ATG2B	55102	broad.mit.edu	37	14	96783571	96783572	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:96783571_96783572insT	ENST00000359933.4	-	20	4013_4014	c.3120_3121insA	c.(3118-3123)aatagafs	p.NR1040fs		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1040										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGAGAGTCTAATTTTTTTTTCC	0.371													10	384	---	---	---	---					
IGHV3-48	0	broad.mit.edu	37	14	106993939	106993941	+	RNA	DEL	TAC	TAC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr14:106993939_106993941delTAC	ENST00000390624.2	-	0	302_304																											TAGTATATGGTACTACTACTACT	0.502													11	1166	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25324325	25324325	+	RNA	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:25324325delT	ENST00000549804.2	+	0	1377																											ACAACTGTCATTTTTTTTGAT	0.478													9	399	---	---	---	---					
OCA2	4948	broad.mit.edu	37	15	28200305	28200305	+	Splice_Site	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:28200305delT	ENST00000354638.3	-	17	1996	c.1842_splice	c.e17+1	p.K614_splice	OCA2_ENST00000353809.5_Splice_Site_p.K590_splice|OCA2_ENST00000382996.2_Splice_Site_p.K614_splice	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	614			K -> E (in OCA2).|K -> N (in OCA2).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCTGGGTACCTTTTTTTGGAG	0.443									Oculocutaneous Albinism				7	876	---	---	---	---					
FAM63B	54629	broad.mit.edu	37	15	59144132	59144134	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:59144132_59144134delGCT	ENST00000559228.1	+	8	1787_1789	c.1705_1707delGCT	c.(1705-1707)del	p.A574del	FAM63B_ENST00000450403.2_In_Frame_Del_p.A574del			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	574	Gln-rich.									central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						ACAAGCAGCAGCTGCTGCTGCTG	0.468													7	475	---	---	---	---					
ZNF609	23060	broad.mit.edu	37	15	64967246	64967247	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:64967246_64967247insA	ENST00000326648.3	+	4	2321_2322	c.2193_2194insA	c.(2191-2196)gaaaaafs	p.EK731fs		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	731	Poly-Lys.					nucleus	zinc ion binding	p.K734fs*12(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AAAAGAAAGACAAAAAAAAGAA	0.490													11	874	---	---	---	---					
MYO9A	4649	broad.mit.edu	37	15	72190580	72190580	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr15:72190580delA	ENST00000356056.5	-	25	4736	c.4264delT	c.(4264-4266)atfs	p.Y1422fs	MYO9A_ENST00000424560.1_Frame_Shift_Del_p.Y1422fs|MYO9A_ENST00000444904.1_Frame_Shift_Del_p.Y1403fs|MYO9A_ENST00000566885.1_Frame_Shift_Del_p.Y1042fs|MYO9A_ENST00000564571.1_Frame_Shift_Del_p.Y1422fs|MYO9A_ENST00000563542.1_5'UTR	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1422	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TGGGGGATATAAAAAAAAGTA	0.398													8	440	---	---	---	---					
Z84812.4	0	broad.mit.edu	37	16	81973	81974	+	RNA	INS	-	-	GTCC			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:81973_81974insGTCC	ENST00000568710.1	-	0	349																											ATCAGCAGGAGGCCCACCTCGT	0.614													11	48	---	---	---	---					
KIAA0430	9665	broad.mit.edu	37	16	15729982	15729984	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:15729982_15729984delCCA	ENST00000396368.3	-	3	566_568	c.360_362delTGG	c.(358-363)ggc>gg	p.GG120del	KIAA0430_ENST00000548025.1_In_Frame_Del_p.GG120del|KIAA0430_ENST00000602337.1_In_Frame_Del_p.GG120del|KIAA0430_ENST00000551742.1_In_Frame_Del_p.GG120del|KIAA0430_ENST00000540441.2_In_Frame_Del_p.GG120del|KIAA0430_ENST00000344181.3_5'UTR	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	119	Poly-Gly.					peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TCCGCTACCGCCACCACCACCAC	0.532													8	661	---	---	---	---					
RP11-368J21.3	0	broad.mit.edu	37	16	22579763	22579764	+	RNA	DEL	TT	TT	-	rs112473041	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:22579763_22579764delTT	ENST00000550753.1	+	0	1976					NR_003676.2																						tgtgtgtgtgtttgtttgtTTT	0.505													9	489	---	---	---	---					
RP11-1166P10.8	0	broad.mit.edu	37	16	32127005	32127005	+	RNA	DEL	C	C	-	rs78871347		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:32127005delC	ENST00000564145.1	-	0	456																											GCGGCTTTTTCCCCCCACCGC	0.687													3	6	---	---	---	---					
COQ9	57017	broad.mit.edu	37	16	57486732	57486734	+	In_Frame_Del	DEL	GAG	GAG	-	rs149029279		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:57486732_57486734delGAG	ENST00000262507.6	+	3	331_333	c.262_264delGAG	c.(262-264)del	p.E91del	COQ9_ENST00000567072.1_In_Frame_Del_p.E91del|COQ9_ENST00000567384.1_3'UTR|COQ9_ENST00000567933.1_In_Frame_Del_p.E91del	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	91					ubiquinone biosynthetic process	mitochondrion				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						CCAGGGCGGCGAGGAGGAGGAGG	0.576													9	711	---	---	---	---					
SLC9A5	6553	broad.mit.edu	37	16	67300017	67300019	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:67300017_67300019delGAG	ENST00000299798.11	+	15	2172_2174	c.2107_2109delGAG	c.(2107-2109)del	p.E708del		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	708					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CGTGGAGTCTGAGGAGGAGGAGG	0.571													7	242	---	---	---	---					
CDH3	1001	broad.mit.edu	37	16	68718504	68718504	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr16:68718504delA	ENST00000264012.4	+	10	1745	c.1201delA	c.(1201-1203)aafs	p.K401fs	CDH3_ENST00000581171.1_Frame_Shift_Del_p.K346fs|CDH3_ENST00000429102.2_Frame_Shift_Del_p.K401fs	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	401	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TTTTGAGGCCAAAAACCAGCA	0.522													10	1733	---	---	---	---					
EPN2	22905	broad.mit.edu	37	17	19232949	19232950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:19232949_19232950insA	ENST00000314728.5	+	9	1884_1885	c.1400_1401insA	c.(1399-1401)taafs	p.*467fs	EPN2_ENST00000347697.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000571254.1_Frame_Shift_Ins_p.*403fs|EPN2_ENST00000575595.1_Frame_Shift_Ins_p.*175fs|EPN2_ENST00000395618.3_Frame_Shift_Ins_p.*182fs|EPN2_ENST00000395620.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000395626.1_Frame_Shift_Ins_p.*467fs	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding	p.T470fs*19(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTCGGACTTCAAAAAAAACAG	0.396													8	577	---	---	---	---					
STAT5B	6777	broad.mit.edu	37	17	40370236	40370236	+	Frame_Shift_Del	DEL	G	G	-	rs144993426		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:40370236delG	ENST00000293328.3	-	9	1270	c.1102delC	c.(1102-1104)agfs	p.Q368fs		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	368					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GCCTTCACCTGGGGGGGGTTC	0.577													9	306	---	---	---	---					
TRIM25	7706	broad.mit.edu	37	17	54978862	54978862	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:54978862delT	ENST00000316881.4	-	4	1054	c.1005delA	c.(1003-1005)aafs	p.K335fs	TRIM25_ENST00000537230.1_Frame_Shift_Del_p.K335fs	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	335	Interaction with influenza A virus NS1.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					GGTGGATGCCTTTTATCAGCT	0.547													7	1992	---	---	---	---					
ITGB4	3691	broad.mit.edu	37	17	73732157	73732158	+	Frame_Shift_Del	DEL	GT	GT	-	rs121912463		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr17:73732157_73732158delGT	ENST00000200181.3	+	14	1870_1871	c.1683_1684delGT	c.(1681-1686)cagtfs	p.QC561fs	ITGB4_ENST00000449880.2_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000579662.1_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000450894.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000339591.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000584558.1_3'UTR	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	561	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCATGGGCCAGTGTGTGTGTGA	0.604													9	779	---	---	---	---					
ROCK1P1	0	broad.mit.edu	37	18	112519	112520	+	RNA	INS	-	-	A	rs140158594	by1000genomes	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr18:112519_112520insA	ENST00000576266.1	+	0	153_154																											CCAGCTCCCCCGGGGCCTCCGT	0.530													8	120	---	---	---	---					
RP11-595B24.1	0	broad.mit.edu	37	18	19622068	19622068	+	RNA	DEL	C	C	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr18:19622068delC	ENST00000584898.1	+	0	39																											ctgaaaggtgccccccaccct	0.443													2	4	---	---	---	---					
DENND1C	79958	broad.mit.edu	37	19	6477251	6477251	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:6477251delG	ENST00000381480.2	-	8	603	c.491delC	c.(490-492)ctfs	p.P164fs	DENND1C_ENST00000591030.1_5'UTR|DENND1C_ENST00000543576.1_Frame_Shift_Del_p.P120fs	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	164	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						CCCCCGGGTAGGGGGGGGGAT	0.672													11	281	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9057565	9057565	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:9057565delT	ENST00000397910.4	-	3	30084	c.29881delA	c.(29881-29883)gtfs	p.S9962fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9964	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGGAGAACTTTTTTGGGTG	0.488													8	1368	---	---	---	---					
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Frame_Shift_Del	DEL	T	T	-	rs77187934		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:52877717delT	ENST00000597976.1	+	3	325	c.305delT	c.(304-306)atfs	p.I102fs	ZNF880_ENST00000422689.2_Intron|ZNF880_ENST00000600321.1_Intron|ZNF880_ENST00000424032.2_Intron|ZNF880_ENST00000344085.5_Intron			Q6PDB4	ZN880_HUMAN	zinc finger protein 880	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						GGCCCCATAAttttttttttt	0.473													9	46	---	---	---	---					
ZIM3	0	broad.mit.edu	37	19	57646387	57646387	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr19:57646387delT	ENST00000269834.1	-	5	1703	c.1318delA	c.(1318-1320)ccfs	p.T440fs		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCAGTATGGGTTTTTTTATGC	0.403													7	905	---	---	---	---					
ZNF337	26152	broad.mit.edu	37	20	25657231	25657232	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:25657231_25657232delTG	ENST00000376436.1	-	4	1231_1232	c.692_693delCA	c.(691-693)afs	p.T231fs	ZNF337_ENST00000538750.1_Frame_Shift_Del_p.T199fs|RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000252979.5_Frame_Shift_Del_p.T231fs|RP4-694B14.5_ENST00000455791.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ACTTCTCTCCTGTGTGTGTGTT	0.510													7	557	---	---	---	---					
DIDO1	11083	broad.mit.edu	37	20	61512380	61512381	+	Frame_Shift_Ins	INS	-	-	G			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:61512380_61512381insG	ENST00000266070.4	-	16	5252_5253	c.4927_4928insC	c.(4927-4929)cccfs	p.P1643fs	DIDO1_ENST00000395343.1_Frame_Shift_Ins_p.P1643fs	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1643					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CGTGGCGGGGCGGGTGCCCTCC	0.728													8	105	---	---	---	---					
DIDO1	11083	broad.mit.edu	37	20	61537401	61537402	+	Frame_Shift_Ins	INS	-	-	T	rs140153728		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr20:61537401_61537402insT	ENST00000266070.4	-	6	1750_1751	c.1425_1426insA	c.(1423-1428)aaagacfs	p.D476fs	DIDO1_ENST00000395335.2_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000354665.4_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000266071.5_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000395343.1_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000370368.1_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000395340.1_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000370366.1_Frame_Shift_Ins_p.D476fs|DIDO1_ENST00000370371.4_Frame_Shift_Ins_p.D476fs	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	476					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACTGTGGTCTCTTTTTTTTCTG	0.490													7	641	---	---	---	---					
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661172	22661173	+	RNA	INS	-	-	C	rs7410785		TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chr22:22661172_22661173insC	ENST00000426066.1	+	0	264_265					NR_027293.1																						CATACAGGTTTTCCCCCCCCAC	0.411													7	172	---	---	---	---					
FAM155B	27112	broad.mit.edu	37	X	68725672	68725672	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:68725672delA	ENST00000252338.4	+	1	589	c.547delA	c.(547-549)aafs	p.K184fs		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	184						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						CCCCTCCGCCAAAAAAAACTT	0.592													7	212	---	---	---	---					
TSIX	0	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													13	356	---	---	---	---					
BHLHB9	80823	broad.mit.edu	37	X	102004419	102004421	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:102004419_102004421delGAG	ENST00000372735.1	+	4	1081_1083	c.496_498delGAG	c.(496-498)del	p.E171del	BHLHB9_ENST00000361229.4_In_Frame_Del_p.E171del|BHLHB9_ENST00000447531.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000457056.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000448867.1_In_Frame_Del_p.E171del			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	171	Poly-Glu.					cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GTCAGGGGCTGAGGAGGAGGAGG	0.488													7	516	---	---	---	---					
GUCY2F	2986	broad.mit.edu	37	X	108619355	108619355	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:108619355delT	ENST00000218006.2	-	18	3483	c.3192delA	c.(3190-3192)aafs	p.K1064fs		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	1064					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						TCATGAAGCCTTTTTTCCCAA	0.418													7	679	---	---	---	---					
HTATSF1	27336	broad.mit.edu	37	X	135585048	135585050	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:135585048_135585050delAAG	ENST00000535601.1	+	6	1104_1106	c.682_684delAAG	c.(682-684)del	p.K232del	HTATSF1_ENST00000218364.4_In_Frame_Del_p.K232del	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	232	Poly-Lys.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TGATGCCTCAAAGAAGAAGAAGA	0.335													9	278	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994114	140994116	+	In_Frame_Del	DEL	CTC	CTC	-	rs141900922	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:140994114_140994116delCTC	ENST00000285879.4	+	4	1210_1212	c.924_926delCTC	c.(922-927)agc>ag	p.SS312del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	312							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.483										HNSCC(15;0.026)			7	1097	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994639	140994641	+	In_Frame_Del	DEL	CTC	CTC	-	rs144357389	byFrequency	TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:140994639_140994641delCTC	ENST00000285879.4	+	4	1735_1737	c.1449_1451delCTC	c.(1447-1452)agc>ag	p.SS487del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	487							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.473										HNSCC(15;0.026)			8	756	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-3A-A9IJ-01A-11D-A397-08	TCGA-3A-A9IJ-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8bf3938-5f3e-430e-8353-e7d5d41b451b	7f130a3c-8efa-41a2-a092-380ae507db20	g.chrX:140994844_140994846delCCT	ENST00000285879.4	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)del	p.P553del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)			8	1107	---	---	---	---					
