Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													7	623					0	0	1	0	0
STXBP5	0	broad.mit.edu	37	6	147684586	147684586	+	Silent	SNP	A	A	G			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr6:147684586A>G	ENST00000367481.3	+	22	2661	c.2553A>G	c.(2551-2553)aaA>aaG	p.K851K	STXBP5_ENST00000321680.6_Silent_p.K887K|STXBP5_ENST00000179882.6_Silent_p.K542K|STXBP5_ENST00000367480.3_Silent_p.K834K	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	887					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CTGAAGAAAAAGACGAAAAGG	0.433000													4	260					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48010515	48010515	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:48010515C>T	ENST00000234420.4	+	1	295	c.143C>T	c.(142-144)gCg>gTg	p.A48V	MSH6_ENST00000540021.1_Missense_Mutation_p.A48V	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	48				AAPGASPSPGGDAAWSEAGPGP -> GCPRGLSFPRRGCGL ERGWAWA (in Ref. 2; BAA23674/BAA23675).	determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGCGGGGATGCGGCCTGGAGC	0.746000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				4	106					0	0	1	0	0
BACE2	25825	broad.mit.edu	37	21	42613839	42613839	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr21:42613839C>T	ENST00000330333.6	+	4	1175	c.712C>T	c.(712-714)Ccc>Tcc	p.P238S	BACE2_ENST00000328735.6_Missense_Mutation_p.P238S|BACE2_ENST00000347667.4_Missense_Mutation_p.P238S|BACE2_ENST00000466122.1_3'UTR	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	238					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				AGCCGGCTTGCCCGTTGCTGG	0.502000													7	760					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84906612	84906612	+	Silent	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:84906612C>T	ENST00000262424.5	+	10	1220	c.996C>T	c.(994-996)tgC>tgT	p.C332C	CRISPLD2_ENST00000567845.1_Silent_p.C331C|CRISPLD2_ENST00000564567.1_Silent_p.C332C	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	332	LCCL 1.					extracellular region|transport vesicle		p.C332C(1)		endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						CTAGCATATGCCGCGCCGCCA	0.542000													6	462					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000509479.2_Silent_p.Q497Q|MAML3_ENST00000327122.5_Silent_p.Q341Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													5	151					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427759	3427759	+	RNA	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr11:3427759C>T	ENST00000529482.1	+	0	876																											TGTCTGCACACGTCCTGCAGT	0.612000													5	155					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127448571	127448571	+	Silent	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr5:127448571G>A	ENST00000262461.2	+	2	1011	c.822G>A	c.(820-822)acG>acA	p.T274T	SLC12A2_ENST00000343225.4_Silent_p.T274T	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	274					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGTGGTCACGTATACTGCAG	0.368000													5	440					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	ZFHX3_ENST00000397992.5_Silent_p.G2606G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													5	178					0	0	1	0	0
SHMT1	6470	broad.mit.edu	37	17	18243536	18243536	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:18243536G>A	ENST00000316694.3	-	7	769	c.635C>T	c.(634-636)gCc>gTc	p.A212V	SHMT1_ENST00000354098.3_Missense_Mutation_p.A212V|SHMT1_ENST00000352886.6_Missense_Mutation_p.A212V|SHMT1_ENST00000539052.1_Missense_Mutation_p.A74V	NM_004169.3	NP_004160.3	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	212					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)	13					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CCGTAGCCGGGCATATTCCAG	0.587000													5	345					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33454858	33454858	+	Missense_Mutation	SNP	C	C	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr8:33454858C>A	ENST00000256261.4	-	2	693	c.176G>T	c.(175-177)tGt>tTt	p.C59F	DUSP26_ENST00000523956.1_Missense_Mutation_p.C59F	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	59						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGCATGGTTACAGGCTGTCTT	0.562000													4	107					1.23904e-05	1.38604e-05	1	1	0
RRN3P2	0	broad.mit.edu	37	16	29110438	29110438	+	RNA	SNP	T	T	C			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:29110438T>C	ENST00000564580.1	+	0	1111																		p.L368P(6)									TTGCAGTATCTTCAGAGTCTG	0.328000													7	366					0	0	1	0	0
SLC35B2	347734	broad.mit.edu	37	6	44223293	44223293	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr6:44223293G>A	ENST00000393812.3	-	4	592	c.449C>T	c.(448-450)aCg>aTg	p.T150M	SLC35B2_ENST00000393810.1_3'UTR|SLC35B2_ENST00000537814.1_Missense_Mutation_p.T17M|SLC35B2_ENST00000538577.1_Missense_Mutation_p.T57M|SLC35B2_ENST00000495706.1_5'UTR	NM_178148.2	NP_835361.1	Q8TB61	S35B2_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	150					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGCGAGTCCGTAAAGCGCTC	0.592000													5	317					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243736307	243736307	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:243736307C>T	ENST00000366539.1	-	9	940	c.740G>A	c.(739-741)cGc>cAc	p.R247H	AKT3_ENST00000263826.5_Missense_Mutation_p.R247H|AKT3_ENST00000366540.1_Missense_Mutation_p.R247H|AKT3_ENST00000336199.5_Missense_Mutation_p.R247H			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	247	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAAACGTGTGCGGTCCTCAGA	0.418000													4	284					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680623	100680623	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr7:100680623C>T	ENST00000306151.4	+	3	5990	c.5926C>T	c.(5926-5928)Cca>Tca	p.P1976S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1976	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCCCAGC	0.498000													8	1311					0	0	1	0	0
HSPE1	3336	broad.mit.edu	37	2	198367975	198367975	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:198367975G>A	ENST00000233893.5	+	4	744	c.301G>A	c.(301-303)Gta>Ata	p.V101I	HSPE1_ENST00000465573.1_3'UTR|HSPE1_ENST00000409468.1_3'UTR|HSPE1_ENST00000409729.1_Missense_Mutation_p.V46I|MOB4_ENST00000604458.1_Intron	NM_002157.2	NP_002148.1			heat shock 10kDa protein 1											lung(1)	1			Epithelial(96;0.225)			TGGAAAGTACGTAGACTGAAA	0.328000													7	448					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23911703	23911703	+	Silent	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr13:23911703C>T	ENST00000382298.3	-	10	6900	c.6312G>A	c.(6310-6312)ggG>ggA	p.G2104G	SACS_ENST00000402364.1_Silent_p.G1354G|SACS_ENST00000382292.3_Silent_p.G2104G	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2104					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCAAAGGATGCCCCTCCAAGG	0.403000													4	260					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33955010	33955010	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr15:33955010C>T	ENST00000389232.4	+	35	5349	c.5279C>T	c.(5278-5280)gCg>gTg	p.A1760V	RYR3_ENST00000415757.3_Missense_Mutation_p.A1760V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1760	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAGCATAGTGCGGGGACAGAG	0.567000													5	289					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													7	48					0	0	1	0	0
NPNT	255743	broad.mit.edu	37	4	106859478	106859478	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr4:106859478G>A	ENST00000379987.2	+	5	622	c.406G>A	c.(406-408)Gca>Aca	p.A136T	NPNT_ENST00000514622.1_Missense_Mutation_p.A136T|NPNT_ENST00000506666.1_Missense_Mutation_p.A166T|NPNT_ENST00000305572.8_Missense_Mutation_p.A136T|NPNT_ENST00000453617.2_Missense_Mutation_p.A153T|NPNT_ENST00000427316.2_Missense_Mutation_p.A166T	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	136	EGF-like 3.				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CTGCTCCATGGCAAACTGTCA	0.498000													4	262					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61828729	61828729	+	Silent	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr10:61828729G>A	ENST00000280772.1	-	37	12101	c.11910C>T	c.(11908-11910)acC>acT	p.T3970T	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3970	Thr-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						tggtggtagtggtggtggtgg	0.468000													5	433					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69403349	69403349	+	Silent	SNP	C	C	T	rs146629248	byFrequency	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr4:69403349C>T	ENST00000317746.2	-	6	1629	c.1587G>A	c.(1585-1587)agG>agA	p.R529R		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	529					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.R529R(2)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						ATAACTAATCCCTTTTCTTCT	0.408000													6	591					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085080	64085080	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:64085080G>A	ENST00000295902.6	-	8	2767	c.2182C>T	c.(2182-2184)Cgc>Tgc	p.R728C	PRICKLE2-AS1_ENST00000476308.1_RNA|RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2_ENST00000564377.1_Missense_Mutation_p.R784C	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	728	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTCCGCTGGCGCATAAATTGG	0.617000													4	223					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839311	15839311	+	Missense_Mutation	SNP	C	C	T	rs139469467		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:15839311C>T	ENST00000305899.3	+	1	478	c.458C>T	c.(457-459)tCg>tTg	p.S153L		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCTGGTGGCTCGGTCATGGGG	0.592000													5	252					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37698695	37698695	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr8:37698695G>A	ENST00000315215.7	+	16	2551	c.2188G>A	c.(2188-2190)Ggg>Agg	p.G730R	GPR124_ENST00000412232.2_Missense_Mutation_p.G947R			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	947	GPS.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCTGTGCGCCGGGCTACGCTT	0.627000													5	281					0	0	1	0	0
CLN5	1203	broad.mit.edu	37	13	77570161	77570161	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr13:77570161C>T	ENST00000377453.3	+	3	1903	c.611C>T	c.(610-612)gCc>gTc	p.A204V	CLN5_ENST00000485938.1_3'UTR	NM_006493.2	NP_006484.1	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	155					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		GAAATGGATGCCCCTTTCTGG	0.418000													6	506					0	0	1	0	0
DNM1P46	0	broad.mit.edu	37	15	100340379	100340379	+	RNA	SNP	T	T	C			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr15:100340379T>C	ENST00000341853.1	-	0	547					NR_003260.1																						GTGCCTACTCTGCCGACTCCT	0.592000													5	72					0	0	1	0	0
IL17B	27190	broad.mit.edu	37	5	148756445	148756445	+	Silent	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr5:148756445C>T	ENST00000261796.3	-	2	215	c.165G>A	c.(163-165)ccG>ccA	p.P55P	IL17B_ENST00000505432.1_5'UTR	NM_014443.2	NP_055258.1	Q9UHF5	IL17B_HUMAN	interleukin 17B	55					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)|urinary_tract(1)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGGGCATACGGTTTCATCC	0.622000													6	344					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129140359	129140359	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:129140359G>A	ENST00000505956.1	-	2	499	c.337C>T	c.(337-339)Cgg>Tgg	p.R113W	EFCAB12_ENST00000326085.3_Missense_Mutation_p.R113W	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		AGCTCCTGCCGCAGCTTCGAC	0.552000													4	187					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50462043	50462043	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:50462043C>T	ENST00000447370.2	-	7	1310	c.1220G>A	c.(1219-1221)gGa>gAa	p.G407E	SIGLEC11_ENST00000426971.2_Missense_Mutation_p.G407E	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	407	Ig-like C2-type 3.				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CACGGTCTGTCCCCACCGGGT	0.682000													5	238					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44392244	44392244	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr6:44392244C>T	ENST00000371477.3	+	11	1792	c.1493C>T	c.(1492-1494)gCc>gTc	p.A498V		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	498	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCAGAAAATGCCGAGAAGGAG	0.438000													4	183					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51045410	51045410	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr22:51045410G>A	ENST00000399908.2	+	8	2212	c.1496G>A	c.(1495-1497)cGc>cAc	p.R499H	MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.R470H|MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.R764H|MAPK8IP2_ENST00000442429.2_Missense_Mutation_p.R487H|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.R499H|MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.R385H	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	765					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCCATCCCCGCAACAGCTGG	0.612000													5	296					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85950147	85950147	+	Missense_Mutation	SNP	T	T	C			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chrX:85950147T>C	ENST00000373131.1	+	4	1020	c.857T>C	c.(856-858)cTc>cCc	p.L286P	DACH2_ENST00000508860.1_Missense_Mutation_p.L132P|DACH2_ENST00000373125.4_Missense_Mutation_p.L299P|DACH2_ENST00000510272.1_Missense_Mutation_p.L80P	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GCTCCAACCCTCAATCCACTG	0.483000													3	64					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855284	53855284	+	Silent	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:53855284G>A	ENST00000458035.1	+	4	1473	c.1356G>A	c.(1354-1356)tcG>tcA	p.S452S	ZNF845_ENST00000595091.1_Silent_p.S452S	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S452S(2)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GTTTCAAATCGAACCTTGAAA	0.398000													7	375					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821618	72821618	+	Silent	SNP	A	A	G	rs112443847		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:72821618A>G	ENST00000268489.5	-	10	11229	c.10557T>C	c.(10555-10557)ggT>ggC	p.G3519G	ZFHX3_ENST00000397992.5_Silent_p.G2605G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3519	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G3519G(3)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccaccgccgccgc	0.716000													4	171					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1268340	1268340	+	Silent	SNP	A	A	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr11:1268340A>T	ENST00000447027.1	+	31	10297	c.10239A>T	c.(10237-10239)ccA>ccT	p.P3413P	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.P3410P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3410	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		cctcaactccagggacaactc	0.637000													4	32					0	0	1	0	0
DUSP13	0	broad.mit.edu	37	10	76855494	76855494	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr10:76855494G>A	ENST00000491677.2	-	7	1162	c.620C>T	c.(619-621)gCc>gTc	p.A207V	DUSP13_ENST00000464872.1_Missense_Mutation_p.A78V|DUSP13_ENST00000478873.2_Missense_Mutation_p.A214V|DUSP13_ENST00000607131.1_Missense_Mutation_p.A171V|DUSP13_ENST00000372700.3_Missense_Mutation_p.A128V|DUSP13_ENST00000372702.3_3'UTR|DUSP13_ENST00000605915.1_Missense_Mutation_p.A100V|DUSP13_ENST00000472493.2_Missense_Mutation_p.A78V	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	70						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GCCTGCAGCGGCATTCACAAC	0.577000													10	596					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355167	33355167	+	Missense_Mutation	SNP	C	C	A	rs121908480	byFrequency	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:33355167C>A	ENST00000023064.4	-	4	504	c.313G>T	c.(313-315)Ggg>Tgg	p.G105W	SLC7A9_ENST00000587772.1_Missense_Mutation_p.G105W|SLC7A9_ENST00000590341.1_Missense_Mutation_p.G105W	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	105			G -> R (in CSNU; type III; frequent mutation; severe loss of amino acid transport activity).		blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding	p.G105W(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GGGATGGGCCCGTAGGCCTCC	0.592000													4	156					1	1	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102292989	102292989	+	RNA	SNP	C	C	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr15:102292989C>A	ENST00000561463.1	+	0	1035																											TGCTGTCCAACCTGCACTCGC	0.582000													5	74					5.18039e-06	5.89493e-06	1	1	0
MST1	4485	broad.mit.edu	37	3	49723603	49723603	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:49723603G>A	ENST00000449682.2	-	9	1400	c.1039C>T	c.(1039-1041)Cgg>Tgg	p.R347W	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	333	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity	p.R333W(5)		NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCGGGGTTCCGGCAGAAGTTC	0.662000													5	94					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49701953	49701953	+	Silent	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:49701953C>T	ENST00000296452.4	+	9	11820	c.11706C>T	c.(11704-11706)ggC>ggT	p.G3902G		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3902					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCCTCCCTGGCGGGGCAGCCG	0.642000													5	265					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9886894	9886894	+	Missense_Mutation	SNP	A	A	G	rs146821851		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr18:9886894A>G	ENST00000306084.6	+	2	617	c.418A>G	c.(418-420)Aaa>Gaa	p.K140E	TXNDC2_ENST00000584255.1_3'UTR|TXNDC2_ENST00000426718.3_3'UTR|TXNDC2_ENST00000536353.2_Missense_Mutation_p.K73E|TXNDC2_ENST00000357775.4_Missense_Mutation_p.K73E	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	140	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity	p.K140E(2)|p.K73E(2)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GTCCTCAGAAAAAGCCATCCA	0.547000													6	493					0	0	1	0	0
IGKV1D-16	0	broad.mit.edu	37	2	90139477	90139477	+	RNA	SNP	G	G	A	rs2848291	by1000genomes	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:90139477G>A	ENST00000492446.1	+	0	275																											GTCCCATCAAGGTTCAGCGGC	0.483000													7	586					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													4	190					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67794755	67794755	+	Missense_Mutation	SNP	C	C	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr18:67794755C>A	ENST00000255674.6	-	25	3652	c.3366G>T	c.(3364-3366)tgG>tgT	p.W1122C	RTTN_ENST00000437017.1_Missense_Mutation_p.W1122C|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1122							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				GTGCGGTGTGCCAAGCCAAGG	0.463000													4	168					0.00024832	0.000264341	1	1	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664743	22664743	+	RNA	SNP	G	G	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr22:22664743G>A	ENST00000426066.1	+	0	924					NR_027293.1																						CAGACTAAAGGCAAACAAGGA	0.498000													5	132					0	0	1	0	0
RP11-296I10.6	0	broad.mit.edu	37	16	70253871	70253871	+	RNA	SNP	A	A	G			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:70253871A>G	ENST00000581050.1	-	0	1619					NR_033959.1																						GTAAAGCTTCACCGAAGAGTG	0.388000													3	73					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170884937	170884937	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:170884937C>T	ENST00000436636.2	-	10	1240	c.896G>A	c.(895-897)cGc>cAc	p.R299H	TNIK_ENST00000470834.1_Missense_Mutation_p.R299H|TNIK_ENST00000538048.1_Missense_Mutation_p.R299H|TNIK_ENST00000341852.6_Missense_Mutation_p.R299H|TNIK_ENST00000369326.5_Missense_Mutation_p.R299H|TNIK_ENST00000475336.1_Missense_Mutation_p.R299H|TNIK_ENST00000488470.1_Missense_Mutation_p.R299H|TNIK_ENST00000357327.5_Missense_Mutation_p.R299H|TNIK_ENST00000284483.8_Missense_Mutation_p.R299H|TNIK_ENST00000460047.1_Missense_Mutation_p.R299H	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	299	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GAGTTGAATGCGGACCTGTCG	0.428000													4	153					0	0	1	0	0
WNT9B	7484	broad.mit.edu	37	17	44950050	44950050	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:44950050C>T	ENST00000393461.2	+	2	298	c.245C>T	c.(244-246)gCg>gTg	p.A82V	WNT9B_ENST00000290015.2_Missense_Mutation_p.A82V			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	82					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGGGATGCTGCGCACCTCGGC	0.662000													4	136					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													7	75					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40028015	40028016	+	Frame_Shift_Ins	INS	-	-	G			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:40028015_40028016insG	ENST00000372857.3	-	13	2485_2486	c.1693_1694insC	c.(1693-1695)ggafs	p.G565fs	PABPC4_ENST00000372858.3_Frame_Shift_Ins_p.G581fs|PABPC4_ENST00000372862.3_Frame_Shift_Ins_p.G536fs|PABPC4_ENST00000372856.3_Frame_Shift_Ins_p.G552fs	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	565	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTTCTGTTCCTGGGGGGGTGCT	0.604													7	310	---	---	---	---					
IPP	3652	broad.mit.edu	37	1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:46184897_46184898delAC	ENST00000396478.3	-	6	1265_1266	c.1163_1164delGT	c.(1162-1164)tfs	p.C388fs		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													7	259	---	---	---	---					
GBP5	115362	broad.mit.edu	37	1	89732166	89732166	+	Frame_Shift_Del	DEL	T	T	-	rs34148688		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:89732166delT	ENST00000343435.5	-	7	1267	c.731delA	c.(730-732)agfs	p.K244fs	GBP5_ENST00000481145.1_5'UTR|GBP5_ENST00000370459.3_Frame_Shift_Del_p.K244fs|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	244						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TTGGGCAAGCTTTTTTTGGTG	0.388													8	576	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143210446	143210446	+	RNA	DEL	T	T	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:143210446delT	ENST00000412204.2	-	0	624				RP11-782C8.1_ENST00000438000.1_lincRNA																							GTCCATATACTAAAAAGGTTA	0.284													9	120	---	---	---	---					
PVRL4	81607	broad.mit.edu	37	1	161059028	161059030	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:161059028_161059030delAGC	ENST00000368012.3	-	1	359_361	c.57_59delGCT	c.(55-60)cta>ct	p.LL21del		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	21					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCCAGCAGTAGCAGCAGCAGCA	0.567													7	447	---	---	---	---					
TMCO1	54499	broad.mit.edu	37	1	165712550	165712551	+	Splice_Site	INS	-	-	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:165712550_165712551insA	ENST00000367881.5	-	6	752		c.e6-2		TMCO1_ENST00000580248.1_Splice_Site|TMCO1_ENST00000464650.1_Splice_Site|TMCO1_ENST00000392129.6_Splice_Site			Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CCATCAAATCTAAAAGAAAAAA	0.381													9	260	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222376802	222376802	+	RNA	DEL	T	T	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr1:222376802delT	ENST00000416510.1	-	0	278																											TTCCTCCAGGTTATATCATGC	0.433													2	4	---	---	---	---					
AC113607.1	0	broad.mit.edu	37	2	859471	859472	+	RNA	DEL	CA	CA	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:859471_859472delCA	ENST00000414556.1	-	0	309					NR_033880.1																						ACCCCCCCCCCAGCCCCCACTG	0.663													4	5	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:26022304_26022306delCTG	ENST00000435504.4	-	5	644_646	c.351_353delCAG	c.(349-354)agt>ag	p.SS117del	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000336112.4_In_Frame_Del_p.SS89del|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	117	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													7	609	---	---	---	---					
USP34	9736	broad.mit.edu	37	2	61575023	61575025	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:61575023_61575025delTGG	ENST00000398571.2	-	15	2341_2343	c.2265_2267delCCA	c.(2263-2268)cat>ca	p.HH759del		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	759					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			gtggtggtgatggtggtggtggt	0.389													10	272	---	---	---	---					
SP3	6670	broad.mit.edu	37	2	174829202	174829204	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:174829202_174829204delGCC	ENST00000310015.6	-	2	615_617	c.85_87delGGC	c.(85-87)del	p.G29del	SP3_ENST00000455789.2_In_Frame_Del_p.G17del	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	29	Poly-Gly.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			ACTcgccgtggccgccgccgccg	0.719													2	4	---	---	---	---					
GTF3C3	9330	broad.mit.edu	37	2	197649613	197649614	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr2:197649613_197649614insT	ENST00000263956.3	-	8	1170_1171	c.1081_1082insA	c.(1081-1083)ttcfs	p.F361fs	GTF3C3_ENST00000409364.3_Frame_Shift_Ins_p.F361fs	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	361						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTCTTCTGAAGTTTTTTTTTCC	0.337													8	271	---	---	---	---					
KIAA2018	205717	broad.mit.edu	37	3	113380090	113380090	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr3:113380090delT	ENST00000316407.4	-	7	849	c.439delA	c.(439-441)ttfs	p.I148fs	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Frame_Shift_Del_p.I148fs	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	148					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TAAACAATAATTTTTTTTTGA	0.373													10	457	---	---	---	---					
ZNF876P	0	broad.mit.edu	37	4	217874	217874	+	RNA	DEL	G	G	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr4:217874delG	ENST00000356347.3	+	0	172					NR_027481.1																						ggctgcttcagggagcacagc	0.537													7	135	---	---	---	---					
KLF3	51274	broad.mit.edu	37	4	38691476	38691476	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr4:38691476delC	ENST00000261438.5	+	4	976	c.671delC	c.(670-672)tcfs	p.S224fs	KLF3_ENST00000514033.1_Frame_Shift_Del_p.S224fs	NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	224	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						AACTCAGTGTCCCCCCCGCAA	0.423													8	713	---	---	---	---					
RIOK1	83732	broad.mit.edu	37	6	7393450	7393452	+	In_Frame_Del	DEL	GAC	GAC	-	rs2274212	byFrequency	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr6:7393450_7393452delGAC	ENST00000379834.2	+	2	697_699	c.190_192delGAC	c.(190-192)del	p.D69del		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	69							ATP binding|protein serine/threonine kinase activity	p.D57G(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					ggagggttatgacgatgatgatg	0.433													8	259	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32521545	32521546	+	RNA	INS	-	-	AAGG	rs144810212	by1000genomes	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr6:32521545_32521546insAAGG	ENST00000411500.1	-	0	851					NR_001298.1																						TTGGGGAAAGACTTTATCCAGG	0.436													8	6	---	---	---	---					
CLIP2	7461	broad.mit.edu	37	7	73771745	73771746	+	Frame_Shift_Ins	INS	-	-	C			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr7:73771745_73771746insC	ENST00000223398.6	+	6	1480_1481	c.1153_1154insC	c.(1153-1155)cacfs	p.H385fs	CLIP2_ENST00000395060.1_Frame_Shift_Ins_p.H385fs|CLIP2_ENST00000361545.5_Frame_Shift_Ins_p.H385fs	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	385						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GGTGGCCAAGGCCACAAGCCAC	0.629													7	95	---	---	---	---					
CBLL1	79872	broad.mit.edu	37	7	107395909	107395909	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr7:107395909delA	ENST00000440859.2	+	5	880	c.413delA	c.(412-414)gafs	p.E138fs	CBLL1_ENST00000415884.2_Intron|CBLL1_ENST00000222597.2_Frame_Shift_Del_p.E137fs	NM_024814.2	NP_079090.2	Q75N03	HAKAI_HUMAN	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase	138					cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						ATTTTACATGAAAAAAAGGGA	0.269													7	862	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	GGGGGTGCAAGGTGA	-	rs11270020		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	ENST00000308860.6	+	12	1301_1311	c.1267_splice	c.e12+1	p.L419_splice		NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	419	Protein kinase.					integral to membrane	protein serine/threonine kinase activity	p.?(2)		endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.730													4	6	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89405323	89405326	+	RNA	DEL	TTTA	TTTA	-	rs34562444		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr11:89405323_89405326delTTTA	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						aattatattgtttatttatttttg	0.230													10	22	---	---	---	---					
KIF21A	55605	broad.mit.edu	37	12	39713783	39713784	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr12:39713783_39713784insT	ENST00000395670.3	-	27	4122_4123	c.3703_3704insA	c.(3703-3705)tccfs	p.S1235fs	KIF21A_ENST00000547745.1_5'UTR|KIF21A_ENST00000361961.3_Frame_Shift_Ins_p.S1222fs|KIF21A_ENST00000361418.5_Frame_Shift_Ins_p.S1235fs|KIF21A_ENST00000541463.2_Frame_Shift_Ins_p.S1199fs|KIF21A_ENST00000544797.2_Frame_Shift_Ins_p.S1215fs			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1235					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				AGGCTCTGGAATTTTTTTTTCT	0.342													7	548	---	---	---	---					
EBPL	84650	broad.mit.edu	37	13	50235208	50235209	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr13:50235208_50235209insA	ENST00000242827.6	-	4	566_567	c.516_517insT	c.(514-519)ttacggfs	p.LR172fs	EBPL_ENST00000495963.2_5'UTR|EBPL_ENST00000378272.5_3'UTR|EBPL_ENST00000378270.5_Stop_Codon_Ins|EBPL_ENST00000378284.2_3'UTR	NM_032565.3	NP_115954.1	Q9BY08	EBPL_HUMAN	emopamil binding protein-like	172					sterol metabolic process	endoplasmic reticulum membrane|integral to membrane	cholestenol delta-isomerase activity	p.F172fs*7(1)		endometrium(8)|kidney(6)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Lung NSC(96;0.000468)|Breast(56;0.0011)|Prostate(109;0.00243)|Hepatocellular(98;0.0556)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.06e-09)		CACACACCGTTAAAAAAAAACA	0.480													7	239	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr14:72190482_72190484delTCC	ENST00000555818.1	+	16	4738_4740	c.4390_4392delTCC	c.(4390-4392)del	p.S1468del	SIPA1L1_ENST00000537413.1_In_Frame_Del_p.S922del|SIPA1L1_ENST00000358550.2_In_Frame_Del_p.S1447del|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000381232.3_In_Frame_Del_p.S1447del	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													9	492	---	---	---	---					
TERF2IP	54386	broad.mit.edu	37	16	75690204	75690206	+	In_Frame_Del	DEL	GAA	GAA	-	rs140846731		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:75690204_75690206delGAA	ENST00000300086.4	+	3	992_994	c.895_897delGAA	c.(895-897)del	p.E304del		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	304	Asp/Glu-rich (acidic).				negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						TGATgaggaggaagaagaagaag	0.424													13	300	---	---	---	---					
ANKRD11	29123	broad.mit.edu	37	16	89349640	89349641	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr16:89349640_89349641insT	ENST00000301030.4	-	9	3769_3770	c.3309_3310insA	c.(3307-3312)aaatgafs	p.*1104fs	ANKRD11_ENST00000378330.2_Frame_Shift_Ins_p.*1104fs	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1104	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTTGTCATCTTTTTTTTCAG	0.465													7	752	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3721809	3721811	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:3721809_3721811delTCC	ENST00000158149.3	-	11	1111_1113	c.216_218delGGA	c.(214-219)gaa>ga	p.EE78del	C17orf85_ENST00000389005.4_In_Frame_Del_p.EE358del			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	358							nucleotide binding			endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ctcttcctcttcctcctcctcct	0.507													9	442	---	---	---	---					
KRT10	3858	broad.mit.edu	37	17	38978766	38978768	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:38978766_38978768delTCC	ENST00000269576.5	-	1	79_81	c.70_72delGGA	c.(70-72)del	p.G24del	TMEM99_ENST00000301665.3_Intron|TMEM99_ENST00000496847.1_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	24	Gly-rich.|Head.			Missing (in Ref. 1; AAA60544).	epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				ctcctccacatcctcctcctcct	0.547													11	123	---	---	---	---					
STAT5B	6777	broad.mit.edu	37	17	40370236	40370236	+	Frame_Shift_Del	DEL	G	G	-	rs144993426		TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:40370236delG	ENST00000293328.3	-	9	1270	c.1102delC	c.(1102-1104)agfs	p.Q368fs		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	368					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GCCTTCACCTGGGGGGGGTTC	0.577													7	190	---	---	---	---					
LRRC37A3	374819	broad.mit.edu	37	17	62856336	62856336	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr17:62856336delT	ENST00000584306.1	-	11	4458	c.3928delA	c.(3928-3930)ctfs	p.T1310fs	LRRC37A3_ENST00000400877.3_Frame_Shift_Del_p.T348fs|LRRC37A3_ENST00000319651.5_Frame_Shift_Del_p.T1310fs|LRRC37A3_ENST00000334962.5_Frame_Shift_Del_p.T287fs|LRRC37A3_ENST00000339474.5_Frame_Shift_Del_p.T428fs	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1310						integral to membrane		p.T1310S(1)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						CGGGAGCGAGTTTTGTGAAAG	0.418													9	1221	---	---	---	---					
ZNF181	339318	broad.mit.edu	37	19	35231932	35231932	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr19:35231932delG	ENST00000392232.3	+	6	946	c.778delG	c.(778-780)ggfs	p.G260fs	ZNF181_ENST00000492450.1_Frame_Shift_Del_p.G216fs|ZNF181_ENST00000459757.1_Frame_Shift_Del_p.G215fs			Q2M3W8	ZN181_HUMAN	zinc finger protein 181	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TAATAAAAGTGGGGCAGCCTT	0.358													7	619	---	---	---	---					
C21orf58	54058	broad.mit.edu	37	21	47721985	47721986	+	In_Frame_Ins	INS	-	-	TGG	rs144223236	by1000genomes	TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr21:47721985_47721986insTGG	ENST00000291691.7	-	8	2032_2033	c.896_897insCCA	c.(895-897)cgc>cCCAgc	p.299_299R>PS	C21orf58_ENST00000472607.1_5'UTR|C21orf58_ENST00000397683.1_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000397682.3_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000397680.1_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000397679.1_In_Frame_Ins_p.193_193R>PS	NM_058180.3	NP_478060.2	P58505	CU058_HUMAN	chromosome 21 open reading frame 58	299	Poly-His.							p.H299_A300insH(3)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(1)|pancreas(1)	9	Breast(49;0.112)			Colorectal(79;0.239)		GCCACACAGCAtggtggtggtg	0.708													6	6	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610573	42610575	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chr22:42610573_42610575delAGG	ENST00000359486.3	-	1	873_875	c.737_739delCCT	c.(736-741)ttc>t	p.SF246del	TCF20_ENST00000335626.4_In_Frame_Del_p.SF246del	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	246	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GGTGAAGGGAaggaggaggagga	0.507													8	367	---	---	---	---					
PRPS2	5634	broad.mit.edu	37	X	12827359	12827360	+	Frame_Shift_Ins	INS	-	-	C			TCGA-IB-AAUV-01A-11D-A38G-08	TCGA-IB-AAUV-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a6ed3bc0-d0b9-4ab8-b0aa-f95c82c12cc7	2d3fe7a3-7260-43ff-8dc6-1ef945e51bd7	g.chrX:12827359_12827360insC	ENST00000380668.5	+	3	441_442	c.313_314insC	c.(313-315)cccfs	p.P105fs	PRPS2_ENST00000489404.1_Frame_Shift_Ins_p.P105fs|PRPS2_ENST00000398491.2_Frame_Shift_Ins_p.P108fs	NM_001039091.2|NM_002765.4	NP_001034180.1|NP_002756.1	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	105					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						GTAGAGTCGTGCCCCAATTTCT	0.436													7	284	---	---	---	---					
