Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OBSCN	84033	broad.mit.edu	37	1	228495983	228495983	+	Missense_Mutation	SNP	G	G	A	rs56306215		TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:228495983G>A	ENST00000570156.2	+	58	15583	c.15509G>A	c.(15508-15510)cGc>cAc	p.R5170H	OBSCN_ENST00000366709.4_Missense_Mutation_p.R1332H|OBSCN_ENST00000366707.4_Missense_Mutation_p.R1847H|OBSCN_ENST00000422127.1_Missense_Mutation_p.R4213H|OBSCN_ENST00000284548.11_Missense_Mutation_p.R4213H	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4213	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGGGATGGCCGCATCCACACC	0.632000													3	30					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62781406	62781406	+	RNA	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr17:62781406G>A	ENST00000582986.1	-	0	2444					NR_024386.1																						TGGTACTTGCGTCAGCGAGCA	0.622000													3	20					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47200709	47200709	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:47200709C>G	ENST00000296861.2	-	6	2153	c.1760G>C	c.(1759-1761)cGg>cCg	p.R587P		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	587					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GCGTACCTGCCGCAACACTGT	0.532000													50	109					0	0	1	0	0
LRRC1	55227	broad.mit.edu	37	6	53747727	53747727	+	Silent	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:53747727T>C	ENST00000370888.1	+	4	676	c.399T>C	c.(397-399)ctT>ctC	p.L133L	LRRC1_ENST00000370882.1_Silent_p.L133L	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	133						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		TAACATGTCTTTCTGTAAATG	0.333000													14	33					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170858223	170858223	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:170858223G>A	ENST00000436636.2	-	13	1641	c.1297C>T	c.(1297-1299)Cgg>Tgg	p.R433W	TNIK_ENST00000357327.5_Missense_Mutation_p.R433W|TNIK_ENST00000538048.1_Missense_Mutation_p.R433W|TNIK_ENST00000369326.5_Missense_Mutation_p.R433W|TNIK_ENST00000475336.1_Missense_Mutation_p.R433W|TNIK_ENST00000488470.1_Missense_Mutation_p.R433W|TNIK_ENST00000470834.1_Missense_Mutation_p.R433W|TNIK_ENST00000341852.6_Missense_Mutation_p.R433W|TNIK_ENST00000284483.8_Missense_Mutation_p.R433W|TNIK_ENST00000460047.1_Missense_Mutation_p.R433W	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	433	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCCTCCTCCCGGCGCATCTGC	0.652000													16	223					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21370992	21370992	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr13:21370992C>T	ENST00000400602.2	-	17	2562	c.2527G>A	c.(2527-2529)Gaa>Aaa	p.E843K	XPO4_ENST00000255305.6_Missense_Mutation_p.E843K	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	843					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TTGTAAACTTCCATCAATCCA	0.393000													12	33					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038309	75038309	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:75038309C>A	ENST00000326665.5	-	14	3303	c.3085G>T	c.(3085-3087)Gtg>Ttg	p.V1029L	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1029	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCCCTTCCACATCTTCCTTG	0.502000													25	153					3.6726e-16	4.27514e-16	1	1	0
C11orf87	399947	broad.mit.edu	37	11	109294474	109294474	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:109294474G>T	ENST00000327419.6	+	2	518	c.115G>T	c.(115-117)Ggc>Tgc	p.G39C	RP11-708B6.2_ENST00000532992.1_RNA|RP11-708B6.2_ENST00000532929.1_RNA	NM_207645.3	NP_997528.2	Q6NUJ2	CK087_HUMAN	chromosome 11 open reading frame 87	39						integral to membrane				breast(2)|endometrium(1)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17						CCGCGGCCCAGGCGCAGTAGG	0.657000													9	40					2.17888e-05	2.3025e-05	1	1	0
WNT11	7481	broad.mit.edu	37	11	75902893	75902893	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:75902893C>T	ENST00000322563.3	-	4	729	c.605G>A	c.(604-606)cGc>cAc	p.R202H	RP11-619A14.2_ENST00000527314.1_RNA	NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	202					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CAGAGAGGCGCGCAGAGCCTG	0.672000													3	42					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475639	75475639	+	RNA	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:75475639T>C	ENST00000459803.1	-	0	890					NR_024241.1													p.H284R(1)									CTCTGGGTTGTGGACGGTAAA	0.662000													6	86					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452430	26452430	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:26452430A>G	ENST00000244519.2	+	11	1789	c.1546A>G	c.(1546-1548)Aaa>Gaa	p.K516E	BTN3A3_ENST00000339789.4_Missense_Mutation_p.K474E|BTN3A3_ENST00000361232.3_Missense_Mutation_p.K467E	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	516	B30.2/SPRY.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						CCCAATACCAAAAGAAGTAGA	0.517000													15	111					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43323121	43323121	+	Missense_Mutation	SNP	G	G	A	rs150884238		TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:43323121G>A	ENST00000361428.2	-	4	2028	c.1951C>T	c.(1951-1953)Cgc>Tgc	p.R651C	ZNF318_ENST00000318149.3_Missense_Mutation_p.R651C	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	651					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCTGAGAAGCGGTGGTCAACT	0.537000													10	110					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558470	129558470	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr12:129558470C>T	ENST00000422113.2	-	9	3576	c.3250G>A	c.(3250-3252)Gac>Aac	p.D1084N	TMEM132D_ENST00000389441.4_Missense_Mutation_p.D622N	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1084						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCTTTGCAGTCCCCAGGGTCC	0.512000													20	120					0	0	1	0	0
MRPS5	64969	broad.mit.edu	37	2	95774025	95774025	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:95774025C>T	ENST00000272418.2	-	5	740	c.532G>A	c.(532-534)Gag>Aag	p.E178K		NM_031902.3	NP_114108.1	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	178					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						CGGTCCCACTCTTCTCTCTGC	0.532000													20	98					0	0	1	0	0
DMPK	1760	broad.mit.edu	37	19	46281006	46281006	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:46281006G>A	ENST00000600757.1	-	6	1518	c.831C>T	c.(829-831)ttC>ttT	p.F277F	DMPK_ENST00000447742.2_Silent_p.F267F|DMPK_ENST00000458663.2_Silent_p.F267F|DMPK_ENST00000343373.4_Silent_p.F277F|DMPK_ENST00000291270.4_Silent_p.F267F|DMPK_ENST00000354227.5_Silent_p.F267F			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	277	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		TTTCATAGGCGAATACACCCA	0.632000													26	141					0	0	1	0	0
QPRT	23475	broad.mit.edu	37	16	29706251	29706251	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:29706251G>A	ENST00000395384.4	+	2	441	c.280G>A	c.(280-282)Gcc>Acc	p.A94T	QPRT_ENST00000562473.1_Intron|QPRT_ENST00000219771.7_Intron|AC009133.19_ENST00000449759.1_Missense_Mutation_p.132_132insL	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	94					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	CCGGGGCCCTGCCCACTGCCT	0.682000													8	72					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32379114	32379114	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr20:32379114G>A	ENST00000375200.1	+	15	2721	c.2356G>A	c.(2356-2358)Gag>Aag	p.E786K	RP4-553F4.6_ENST00000423074.1_RNA|RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA|ZNF341_ENST00000342427.2_Missense_Mutation_p.E779K			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	786					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GCTGGTGCCCGAGGCTGTCCC	0.706000													7	41					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5394709	5394709	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr18:5394709C>A	ENST00000341928.2	-	22	3577	c.3237G>T	c.(3235-3237)gaG>gaT	p.E1079D	EPB41L3_ENST00000342933.3_Missense_Mutation_p.E1079D|EPB41L3_ENST00000544123.1_Intron|EPB41L3_ENST00000540638.2_Missense_Mutation_p.E857D|EPB41L3_ENST00000400111.3_Missense_Mutation_p.E857D|EPB41L3_ENST00000427684.2_Missense_Mutation_p.E376D|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000542146.1_Missense_Mutation_p.E384D	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1079	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CTGGTGTGATCTCTGTCTCTT	0.527000													17	103					4.75885e-15	5.49665e-15	1	1	0
GLYATL1	92292	broad.mit.edu	37	11	58723306	58723306	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:58723306C>T	ENST00000300079.5	+	7	858	c.808C>T	c.(808-810)Cga>Tga	p.R270*	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Nonsense_Mutation_p.R239*	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	239						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	GGAAAAATACCGAAGGACAGG	0.483000													9	116					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600788	25600788	+	Silent	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:25600788G>C	ENST00000329474.6	+	33	3734	c.3366G>C	c.(3364-3366)cgG>cgC	p.R1122R		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1122					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						ATTCTGAACGGATAGAGGAGA	0.537000													14	70					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991630	21991630	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:21991630A>T	ENST00000594012.1	-	7	1705	c.1191T>A	c.(1189-1191)tgT>tgA	p.C397*	ZNF43_ENST00000354959.4_Nonsense_Mutation_p.C403*|ZNF43_ENST00000595461.1_Nonsense_Mutation_p.C397*|ZNF43_ENST00000598381.1_Nonsense_Mutation_p.C397*	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AAGCTTTGCCACATTCTTCAC	0.363000													9	70					0	0	1	0	0
OPN5	221391	broad.mit.edu	37	6	47762987	47762987	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:47762987C>T	ENST00000489301.2	+	4	529	c.444C>T	c.(442-444)caC>caT	p.H148H	OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000371211.2_Silent_p.H148H|OPN5_ENST00000393699.2_Silent_p.H148H			Q6U736	OPN5_HUMAN	opsin 5	148					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						AAAGAAAGCACGCCTACATCT	0.547000													6	33					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43323141	43323141	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:43323141T>C	ENST00000361428.2	-	4	2008	c.1931A>G	c.(1930-1932)cAc>cGc	p.H644R	ZNF318_ENST00000318149.3_Missense_Mutation_p.H644R	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	644					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TGAGGAACAGTGGTCAGCTGA	0.547000													16	109					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45401151	45401151	+	Splice_Site	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr15:45401151C>A	ENST00000389039.6	-	12	1620		c.e12-1		DUOX2_ENST00000603300.1_Splice_Site			Q9NRD8	DUOX2_HUMAN	dual oxidase 2						cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GGCCAGTAATCTGAAGAGGAG	0.542000													10	39					0.000442599	0.000464418	1	1	0
DNAAF1	123872	broad.mit.edu	37	16	84208329	84208329	+	Splice_Site	SNP	G	G	C	rs139519641	byFrequency	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:84208329G>C	ENST00000378553.5	+	10	1822		c.e10+1		DNAAF1_ENST00000563818.1_Splice_Site	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1						axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GGAAGACCAGGTTAAGGTCAT	0.453000											OREG0023983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	60					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56385249	56385249	+	Silent	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr17:56385249G>C	ENST00000355701.3	-	23	5655	c.4785C>G	c.(4783-4785)ccC>ccG	p.P1595P	BZRAP1_ENST00000343736.4_Silent_p.P1595P|BZRAP1_ENST00000268893.6_Silent_p.P1535P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1595						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCTCTTCTGGGGGCCCCTCC	0.622000													7	34					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135763005	135763005	+	Splice_Site	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:135763005C>T	ENST00000375845.3	-	3	265	c.235_splice	c.e3+1	p.G79_splice	MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Splice_Site_p.G96_splice|MAP3K19_ENST00000392917.3_Splice_Site_p.G79_splice|MAP3K19_ENST00000392918.3_Splice_Site_p.G79_splice|MAP3K19_ENST00000358371.4_Splice_Site_p.E79_splice|MAP3K19_ENST00000375844.3_Splice_Site_p.G79_splice	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		AGCCCAGTACCTTCTGTCCTG	0.438000													9	54					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72967823	72967823	+	Silent	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:72967823G>T	ENST00000262209.4	-	12	1584	c.1377C>A	c.(1375-1377)atC>atA	p.I459I	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	459						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GACAGGTATTGATACGCCCAT	0.403000													26	107					3.1745e-13	3.61069e-13	1	1	0
SLC36A2	153201	broad.mit.edu	37	5	150723748	150723748	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:150723748G>A	ENST00000335244.4	-	2	374	c.245C>T	c.(244-246)gCg>gTg	p.A82V	SLC36A2_ENST00000521967.1_Missense_Mutation_p.A82V	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	82					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGGATGCCCGCGTTCTTCAC	0.547000													6	26					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10793234	10793234	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:10793234C>G	ENST00000449870.1	+	13	1719	c.1402C>G	c.(1402-1404)Ccg>Gcg	p.P468A	ILF3_ENST00000318511.3_Missense_Mutation_p.P468A|ILF3_ENST00000420083.1_Missense_Mutation_p.P468A|ILF3_ENST00000588657.1_Missense_Mutation_p.P468A|ILF3_ENST00000589998.1_Missense_Mutation_p.P468A|ILF3_ENST00000592763.1_Missense_Mutation_p.P468A|ILF3_ENST00000590261.1_Missense_Mutation_p.P468A|ILF3_ENST00000407004.3_Missense_Mutation_p.P468A|ILF3_ENST00000250241.8_Missense_Mutation_p.P468A	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	468					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CATGGGCTTGCCGACGGGTGC	0.652000													4	53					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	211019032	211019032	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:211019032T>A	ENST00000281772.9	-	2	538	c.275A>T	c.(274-276)cAc>cTc	p.H92L	KANSL1L_ENST00000429908.2_5'UTR|KANSL1L_ENST00000457374.1_Missense_Mutation_p.H92L|KANSL1L_ENST00000452086.1_Missense_Mutation_p.H92L|KANSL1L_ENST00000418791.1_Missense_Mutation_p.H92L	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	92																	ATTCTCATTGTGTTTATTTAA	0.308000													11	123					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372559	175372559	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:175372559G>A	ENST00000367674.1	-	4	1401	c.693C>T	c.(691-693)tcC>tcT	p.S231S	TNR_ENST00000263525.2_Silent_p.S231S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	231	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACCGGAGTTCGGAACAGTCAT	0.637000													19	125					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35546716	35546716	+	Silent	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr9:35546716A>G	ENST00000455600.1	+	2	767	c.198A>G	c.(196-198)ctA>ctG	p.L66L	RUSC2_ENST00000468041.1_3'UTR	NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	66						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACTCCCTGCTATTCAGCAGCC	0.587000													11	58					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29130641	29130641	+	Silent	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr22:29130641G>T	ENST00000382580.2	-	2	144	c.69C>A	c.(67-69)ggC>ggA	p.G23G	CHEK2_ENST00000382566.1_Silent_p.G23G|CHEK2_ENST00000405598.1_Silent_p.G23G|CHEK2_ENST00000382565.1_Silent_p.G23G|CHEK2_ENST00000403642.1_Silent_p.G23G|CHEK2_ENST00000328354.6_Silent_p.G23G|CHEK2_ENST00000402731.1_Silent_p.G23G|CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000348295.3_Silent_p.G23G|CHEK2_ENST00000404276.1_Silent_p.G23G|CHEK2_ENST00000382578.1_Silent_p.G23G	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	23					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						GGGTAACGCTGCCATGGGGCT	0.562000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					32	79					8.4185e-14	9.6489e-14	1	1	0
ABCC11	85320	broad.mit.edu	37	16	48232154	48232154	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:48232154C>A	ENST00000394747.1	-	15	2464	c.2115G>T	c.(2113-2115)ttG>ttT	p.L705F	ABCC11_ENST00000394748.1_Missense_Mutation_p.L705F|ABCC11_ENST00000356608.2_Missense_Mutation_p.L705F|ABCC11_ENST00000353782.5_Missense_Mutation_p.L705F|ABCC11_ENST00000537808.1_Missense_Mutation_p.L705F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	705	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TCCCATTTTCCAACAAAATGA	0.378000													15	81					3.27435e-08	3.56116e-08	1	1	0
PCDHGA5	56110	broad.mit.edu	37	5	140745430	140745430	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:140745430C>T	ENST00000518069.1	+	1	1533	c.1533C>T	c.(1531-1533)acC>acT	p.T511T	PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCTGACACCGGTGTCCTGT	0.557000													26	231					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946775	70946775	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr12:70946775C>T	ENST00000334414.6	-	21	5213	c.5169G>A	c.(5167-5169)caG>caA	p.Q1723Q	PTPRB_ENST00000261266.5_Silent_p.Q1505Q|PTPRB_ENST00000550857.1_Silent_p.Q1415Q|PTPRB_ENST00000550358.1_Silent_p.Q1635Q|PTPRB_ENST00000538708.1_Silent_p.Q1415Q|PTPRB_ENST00000451516.2_Silent_p.Q1415Q	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1505	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GAGGGTGCTGCTGTTCTGGCT	0.453000													32	168					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52881537	52881537	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr12:52881537G>A	ENST00000330722.6	-	9	1730	c.1662C>T	c.(1660-1662)acC>acT	p.T554T		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	554	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGAGGAGGAGGTGGTGGTGT	0.597000													17	119					0	0	1	0	0
SUGP1	57794	broad.mit.edu	37	19	19414163	19414163	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:19414163G>A	ENST00000247001.5	-	6	1104	c.757C>T	c.(757-759)Cag>Tag	p.Q253*	SUGP1_ENST00000585763.1_5'UTR	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	253					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CTACCTTTCTGAGAGGCTGCC	0.552000													13	68					0	0	1	0	0
LYSMD3	116068	broad.mit.edu	37	5	89815001	89815001	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:89815001C>A	ENST00000315948.6	-	3	700	c.556G>T	c.(556-558)Gta>Tta	p.V186L	LYSMD3_ENST00000509384.1_3'UTR|LYSMD3_ENST00000500869.2_Intron	NM_198273.1	NP_938014.1	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain containing 3	186					cell wall macromolecule catabolic process	integral to membrane				breast(2)|large_intestine(1)|lung(2)|prostate(1)|urinary_tract(1)	7		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		AAGGCCGATACTACCTCATTG	0.408000													22	113					7.33628e-21	8.67544e-21	1	1	0
RYR2	6262	broad.mit.edu	37	1	237713905	237713905	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:237713905A>G	ENST00000366574.2	+	27	3445	c.3128A>G	c.(3127-3129)aAg>aGg	p.K1043R	RYR2_ENST00000360064.6_Missense_Mutation_p.K1041R|RYR2_ENST00000542537.1_Missense_Mutation_p.K1027R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1043	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACCGAACCAAGAAATCCAAC	0.507000													3	10					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6082016	6082016	+	Silent	SNP	C	C	T	rs150623866		TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr4:6082016C>T	ENST00000409021.3	-	7	1574	c.1125G>A	c.(1123-1125)gcG>gcA	p.A375A	JAKMIP1_ENST00000282924.5_Silent_p.A375A|JAKMIP1_ENST00000409831.1_Silent_p.A375A|JAKMIP1_ENST00000409371.3_Silent_p.A210A|JAKMIP1_ENST00000410077.2_Silent_p.A210A|JAKMIP1_ENST00000457227.2_5'UTR	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	375	Mediates interaction with TYK2 and GABBR1.		A -> V (in a colorectal cancer sample; somatic mutation).		protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTTCAGAGACGCCTGCGCTG	0.577000													4	35					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76708950	76708950	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:76708950T>A	ENST00000264917.5	+	17	1772	c.1727T>A	c.(1726-1728)cTg>cAg	p.L576Q	PDE8B_ENST00000505283.1_Missense_Mutation_p.L41Q|PDE8B_ENST00000340978.3_Missense_Mutation_p.L529Q|PDE8B_ENST00000342343.4_Missense_Mutation_p.L556Q|PDE8B_ENST00000333194.4_Missense_Mutation_p.L521Q|PDE8B_ENST00000346042.3_Missense_Mutation_p.L479Q	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	576					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TTGGTTTATCTGGGCTTAAAG	0.448000													12	135					0	0	1	0	0
ERI1	90459	broad.mit.edu	37	8	8869081	8869081	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:8869081T>A	ENST00000523898.1	+	4	996	c.317T>A	c.(316-318)cTg>cAg	p.L106Q	ERI1_ENST00000519292.1_Missense_Mutation_p.L106Q|ERI1_ENST00000250263.7_Missense_Mutation_p.L106Q			Q8IV48	ERI1_HUMAN	exoribonuclease 1	106	SAP.				gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11					Adenosine monophosphate(DB00131)	AAGAAGAGACTGAAAAACTAT	0.348000													10	43					0	0	1	0	0
ZNF154	7710	broad.mit.edu	37	19	58213858	58213858	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:58213858T>A	ENST00000512439.2	-	3	655	c.459A>T	c.(457-459)agA>agT	p.R153S	ZNF154_ENST00000426889.1_Missense_Mutation_p.R153S|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron			Q13106	ZN154_HUMAN	zinc finger protein 154	153						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TAGTGAGGGTTCTCTGCTGCT	0.448000													70	277					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149877520	149877520	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:149877520C>T	ENST00000369146.3	-	12	2447	c.1957G>A	c.(1957-1959)Gct>Act	p.A653T	SV2A_ENST00000369145.1_Missense_Mutation_p.A653T	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	653					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAGAGCAGAGCGATCATGGCC	0.547000													28	125					0	0	1	0	0
CCDC6	8030	broad.mit.edu	37	10	61592365	61592365	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr10:61592365T>C	ENST00000263102.6	-	3	731	c.500A>G	c.(499-501)cAg>cGg	p.Q167R		NM_005436.4	NP_005427.2	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	167	5 X 29 AA tandem repeats.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton		CCDC6/RET(4)	breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|stomach(1)	18				Kidney(211;0.0597)		CTGAAATTCCTGCTCTTGTTC	0.398000			T	RET	NSCLC								10	71					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37696570	37696570	+	Missense_Mutation	SNP	G	G	A	rs139221615	byFrequency	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:37696570G>A	ENST00000315215.7	+	12	2068	c.1705G>A	c.(1705-1707)Gcc>Acc	p.A569T	GPR124_ENST00000412232.2_Missense_Mutation_p.A786T			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	786					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CTGCCTCTTCGCCACCATCAT	0.677000													11	38					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7862723	7862723	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:7862723G>T	ENST00000283147.6	+	4	1355	c.1196G>T	c.(1195-1197)aGt>aTt	p.S399I		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	399					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					CGGGTCTCCAGTGCTTCAGGT	0.592000													5	50					0.184627	0.185875	1	1	0
MISP	126353	broad.mit.edu	37	19	758045	758045	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:758045C>T	ENST00000215582.6	+	2	1202	c.1099C>T	c.(1099-1101)Cgg>Tgg	p.R367W		NM_173481.2	NP_775752.1			mitotic spindle positioning																		AGACCACCGGCGGGAGGGCCT	0.687000													3	21					0	0	1	0	0
CHML	1122	broad.mit.edu	37	1	241798408	241798408	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:241798408G>A	ENST00000366553.1	-	1	824	c.661C>T	c.(661-663)Caa>Taa	p.Q221*	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	221					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TTAACTATTTGAGAGTAAGTA	0.328000													40	156					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121396297	121396297	+	Splice_Site	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:121396297C>T	ENST00000393667.3	-	16	8984	c.8873_splice	c.e16-1	p.R2958_splice	GOLGB1_ENST00000340645.5_Splice_Site_p.R2953_splice	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2953					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TCTTCTCCATCCTAGAAAAAA	0.413000													15	77					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587832	247587832	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:247587832G>C	ENST00000366497.2	+	4	1867	c.1087G>C	c.(1087-1089)Gac>Cac	p.D363H	NLRP3_ENST00000391828.3_Missense_Mutation_p.D363H|NLRP3_ENST00000366496.2_Missense_Mutation_p.D363H|NLRP3_ENST00000391827.2_Missense_Mutation_p.D363H|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.D363H|NLRP3_ENST00000348069.2_Missense_Mutation_p.D363H	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	363	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCACTTGCTGGACCATCCTCG	0.552000													17	96					0	0	1	0	0
RAB7A	7879	broad.mit.edu	37	3	128532230	128532230	+	Silent	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:128532230C>A	ENST00000265062.3	+	6	835	c.589C>A	c.(589-591)Cgg>Agg	p.R197R	RAB7A_ENST00000482525.1_Silent_p.R150R|RAB7A_ENST00000485280.1_Silent_p.R81R	NM_004637.5	NP_004628.4	P51149	RAB7A_HUMAN	RAB7A, member RAS oncogene family	197					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(114;0.231)		CAAGAATGACCGGGCCAAGGC	0.507000													36	223					9.65963e-10	1.08217e-09	1	1	0
S1PR3	1903	broad.mit.edu	37	9	91616168	91616168	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr9:91616168T>C	ENST00000375846.3	+	1	4748	c.53T>C	c.(52-54)cTg>cCg	p.L18P	S1PR3_ENST00000358157.2_Missense_Mutation_p.L18P			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	18					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						AACGAGACCCTGCGGGAGCAT	0.637000											OREG0019291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	131					0	0	1	0	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226593	168226593	+	RNA	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:168226593T>C	ENST00000359760.5	-	0	796					NR_027906.1																						CTGCTGAGCCTAGCACCGCCC	0.716000													9	101					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577111	7577111	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr17:7577111G>T	ENST00000420246.2	-	8	959	c.827C>A	c.(826-828)gCc>gAc	p.A276D	TP53_ENST00000455263.2_Missense_Mutation_p.A276D|TP53_ENST00000445888.2_Missense_Mutation_p.A276D|TP53_ENST00000359597.4_Missense_Mutation_p.A276D|TP53_ENST00000269305.4_Missense_Mutation_p.A276D|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	276	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		A -> D (in sporadic cancers; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.A276V(7)|p.A276D(6)|p.A276G(4)|p.?(2)|p.A276fs*69(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.A276fs*68(1)|p.L265_K305del41(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.A276fs*70(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCCAGGACAGGCACAAACACG	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	35					2.23348e-06	2.37707e-06	1	1	0
OR8K5	219453	broad.mit.edu	37	11	55927156	55927156	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:55927156A>T	ENST00000313447.1	-	1	637	c.638T>A	c.(637-639)aTa>aAa	p.I213K		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CACTAAGACTATCAGAAAGGA	0.378000													13	105					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36216487	36216487	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:36216487A>T	ENST00000222270.7	+	12	3750	c.3750A>T	c.(3748-3750)aaA>aaT	p.K1250N	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Missense_Mutation_p.K1250N	NM_014727.1	NP_055542.1																					GTCGCTGCAAATTCTGCCACG	0.637000													30	152					0	0	1	0	0
SEC22A	26984	broad.mit.edu	37	3	122944059	122944059	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:122944059A>C	ENST00000309934.4	+	3	1352	c.456A>C	c.(454-456)caA>caC	p.Q152H	SEC22A_ENST00000492595.1_Missense_Mutation_p.Q152H|SEC22A_ENST00000481965.2_Intron|SEC22A_ENST00000477063.1_3'UTR	NM_012430.4	NP_036562.2	Q96IW7	SC22A_HUMAN	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	152					ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			NS(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	10				GBM - Glioblastoma multiforme(114;0.0548)		CTCCTTATCAAATTTCCATGT	0.433000													20	153					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62300566	62300566	+	Silent	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:62300566T>C	ENST00000378024.4	-	5	1597	c.1323A>G	c.(1321-1323)gtA>gtG	p.V441V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	441					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTGCACCTGATACAGAGAACT	0.537000													14	93					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98851130	98851130	+	Silent	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:98851130G>T	ENST00000477737.1	+	17	2532	c.2328G>T	c.(2326-2328)ctG>ctT	p.L776L		NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	776										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AAACCAGCCTGCTCAGAAGCC	0.473000													9	54					5.4927e-09	6.10756e-09	1	1	0
LHX3	8022	broad.mit.edu	37	9	139089573	139089573	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr9:139089573C>T	ENST00000371746.3	-	6	925	c.807G>A	c.(805-807)gcG>gcA	p.A269A	LHX3_ENST00000371748.5_Silent_p.A264A	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	264					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GGCCCATTTCCGCCAAGGAAG	0.677000													4	16					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35422786	35422786	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:35422786G>C	ENST00000439785.1	+	3	493	c.49G>C	c.(49-51)Gag>Cag	p.E17Q	ZNF30_ENST00000601957.1_Missense_Mutation_p.E17Q|ZNF30_ENST00000601540.1_3'UTR|ZNF30_ENST00000303586.7_Missense_Mutation_p.E17Q|ZNF30_ENST00000426813.2_5'UTR|ZNF30_ENST00000601142.1_Missense_Mutation_p.E17Q	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		AGTGACATTTGAGGATGTGGC	0.453000													7	22					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42630014	42630014	+	Splice_Site	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:42630014A>G	ENST00000372901.1	+	31	3793	c.3536_splice	c.e31+1	p.R1179_splice	UBR2_ENST00000372883.3_3'UTR|UBR2_ENST00000372899.1_Splice_Site_p.R1179_splice			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1179					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TTGTTGGCAAAGGTAATGTAT	0.333000													41	115					0	0	1	0	0
IRF2BP2	359948	broad.mit.edu	37	1	234743476	234743476	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:234743476T>C	ENST00000366609.3	-	2	1201	c.1171A>G	c.(1171-1173)Atg>Gtg	p.M391V	RP4-781K5.2_ENST00000436039.1_RNA|IRF2BP2_ENST00000366610.3_Missense_Mutation_p.M375V|IRF2BP2_ENST00000491430.1_5'UTR	NM_182972.2	NP_892017.2	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GTAGGAGTCATGGGGATCTTG	0.612000													9	84					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41176735	41176735	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:41176735A>T	ENST00000263413.3	-	8	1274	c.1010T>A	c.(1009-1011)gTc>gAc	p.V337D	C6_ENST00000337836.5_Missense_Mutation_p.V337D|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	337	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTCAAAAAGACATCAGAAAG	0.383000													18	82					0	0	1	0	0
HCG17	414778	broad.mit.edu	37	6	30227442	30227442	+	RNA	SNP	T	T	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:30227442T>G	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							CTGCTGCTCTTGGGGGCCCTG	0.706000													5	41					0	0	1	0	0
B3GNT7	93010	broad.mit.edu	37	2	232262479	232262479	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:232262479G>A	ENST00000287590.5	+	2	310	c.49G>A	c.(49-51)Gcc>Acc	p.A17T	B3GNT7_ENST00000479618.1_3'UTR	NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	17					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		CCTGGCCCTGGCCCTGCTCGT	0.632000													11	57					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19218754	19218754	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:19218754G>A	ENST00000318596.7	+	7	700	c.549G>A	c.(547-549)ctG>ctA	p.L183L	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	183					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AAGAGGGGCTGAAGACTCTCT	0.567000													23	100					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670474	25670474	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr13:25670474G>A	ENST00000281589.3	+	1	175	c.138G>A	c.(136-138)ttG>ttA	p.L46L		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	46	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GCAGGGACTTGATCACCAGCG	0.567000													9	72					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107216852	107216852	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:107216852C>A	ENST00000542267.1	-	8	2257	c.1851G>T	c.(1849-1851)atG>atT	p.M617I	FBXL17_ENST00000359660.5_Missense_Mutation_p.M219I|FBXL17_ENST00000496714.1_Missense_Mutation_p.M219I	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	617										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TCTCTATTGTCATGCTGTATC	0.458000													13	94					1.5842e-08	1.73563e-08	1	1	0
ZIC2	7546	broad.mit.edu	37	13	100637931	100637931	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr13:100637931G>C	ENST00000376335.3	+	3	1887	c.1594G>C	c.(1594-1596)Gtg>Ctg	p.V532L		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	532					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGAATGGTACGTGTGACGGGT	0.706000													3	15					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105441917	105441917	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:105441917T>C	ENST00000351513.2	-	5	938	c.806A>G	c.(805-807)tAt>tGt	p.Y269C		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	269					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGGTTCACCATAGACCACCTT	0.423000													16	87					0	0	1	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092581	29092581	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:29092581G>A	ENST00000306108.5	-	1	586	c.563C>T	c.(562-564)cCg>cTg	p.P188L		NM_017910.3	NP_060380.3	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B (S. cerevisiae)	188							tRNA (adenine-N1-)-methyltransferase activity	p.P188Q(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	13						CTTGCCGAACGGGACTGCCCC	0.473000													13	129					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3211669	3211669	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr20:3211669T>C	ENST00000380059.3	-	10	1308	c.1207A>G	c.(1207-1209)Atc>Gtc	p.I403V	SLC4A11_ENST00000539553.1_Missense_Mutation_p.I360V|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Missense_Mutation_p.I376V	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	376	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GTGGTGGTGATGTATTTGCCC	0.577000													13	99					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3599913	3599913	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:3599913T>A	ENST00000302006.3	+	2	903	c.851T>A	c.(850-852)cTg>cAg	p.L284Q	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	284						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CCCTTGGGCCTGGCAAAGGAG	0.741000													3	13					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53133435	53133435	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:53133435A>G	ENST00000607203.1	-	1	34	c.35T>C	c.(34-36)gTt>gCt	p.V12A	RFT1_ENST00000296292.3_Silent_p.C390C|RFT1_ENST00000394738.3_Silent_p.C351C																							CAAATGTGAAACACTCTGTCA	0.468000													8	52					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720964	140720964	+	Splice_Site	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:140720964T>C	ENST00000394576.2	+	1	2424		c.e1+2		PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTCTCAGGTAATCTATCTT	0.393000													9	96					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24535227	24535227	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:24535227G>C	ENST00000264463.4	-	5	1315	c.808C>G	c.(808-810)Ccc>Gcc	p.P270A		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	270	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTACTCTGGGGGAAACGTGGT	0.458000										HNSCC(23;0.051)			5	50					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37642616	37642616	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:37642616C>T	ENST00000356958.4	-	5	2443	c.2185G>A	c.(2185-2187)Gac>Aac	p.D729N	ZNF585A_ENST00000392157.2_Missense_Mutation_p.D674N|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.D674N|ZNF585A_ENST00000355533.2_Missense_Mutation_p.D366N			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTGGACCTGTCAGTAAAGGCC	0.458000													18	110					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3977871	3977871	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:3977871G>A	ENST00000309311.6	-	12	2101	c.2013C>T	c.(2011-2013)taC>taT	p.Y671Y		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	671						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCGTTGAGGTACTGCACAC	0.627000													15	93					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155233126	155233126	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:155233126C>A	ENST00000368361.4	-	13	1698	c.1383G>T	c.(1381-1383)gaG>gaT	p.E461D	CLK2_ENST00000536801.1_Missense_Mutation_p.E461D|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000361168.5_Missense_Mutation_p.E460D|CLK2_ENST00000355560.4_Missense_Mutation_p.E459D			P49760	CLK2_HUMAN	CDC-like kinase 2	461	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGGTTCATACTCTAGCATGC	0.567000								Other conserved DNA damage response genes					4	64					0.184627	0.185875	1	1	0
ZNF280B	140883	broad.mit.edu	37	22	22843036	22843036	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr22:22843036G>C	ENST00000360412.2	-	4	1463	c.688C>G	c.(688-690)Cag>Gag	p.Q230E	ZNF280B_ENST00000406426.1_Missense_Mutation_p.Q230E	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GCTCCATTCTGAACATGGCTT	0.368000													56	130					0	0	1	0	0
ID2	3398	broad.mit.edu	37	2	8822561	8822561	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:8822561A>G	ENST00000234091.4	+	3	1126	c.266A>G	c.(265-267)cAt>cGt	p.H89R	ID2_ENST00000396290.1_Missense_Mutation_p.H89R|ID2_ENST00000331129.3_Missense_Mutation_p.H89R			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	89					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCAGCCTGCATCACCAGAGA	0.577000													7	75					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53994161	53994161	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:53994161T>A	ENST00000396403.4	+	4	803	c.675T>A	c.(673-675)aaT>aaA	p.N225K	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AAGCCTTTAATTATAGCTCAC	0.363000													18	143					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37687410	37687410	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:37687410G>C	ENST00000315215.7	+	6	959	c.596G>C	c.(595-597)cGc>cCc	p.R199P	GPR124_ENST00000412232.2_Missense_Mutation_p.R199P			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	199	LRRCT.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGCCACCTGCGCTGGCTGCTG	0.667000													13	52					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418041	64418041	+	Silent	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:64418041G>C	ENST00000265459.6	-	15	3449	c.2988C>G	c.(2986-2988)gtC>gtG	p.V996V	NRXN2_ENST00000377551.1_Silent_p.V996V|NRXN2_ENST00000409571.1_Silent_p.V989V|AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000377559.3_Silent_p.V956V	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	996	Laminin G-like 5.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						GGTTGTCATTGACTGGTTTGT	0.577000											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	154					0	0	1	0	0
PPP5C	5536	broad.mit.edu	37	19	46891878	46891878	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:46891878G>T	ENST00000012443.4	+	11	1348	c.1245G>T	c.(1243-1245)ttG>ttT	p.L415F	PPP5C_ENST00000391919.1_Missense_Mutation_p.L287F	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	415	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		AGGCCTTCTTGGAAGAGAACA	0.612000													11	75					1.58986e-06	1.71659e-06	1	1	0
SLC35B4	84912	broad.mit.edu	37	7	133986850	133986850	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr7:133986850G>C	ENST00000378509.4	-	5	656	c.357C>G	c.(355-357)ttC>ttG	p.F119L		NM_032826.4	NP_116215.1	Q969S0	S35B4_HUMAN	solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4	119				F -> S (in Ref. 6; BAD96594).		Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			large_intestine(1)|lung(2)|skin(1)|stomach(1)	5						AGGTATATTTGAATATACTGT	0.353000													13	53					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138169279	138169279	+	Silent	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:138169279A>G	ENST00000409968.1	+	14	2974	c.2796A>G	c.(2794-2796)ggA>ggG	p.G932G	THSD7B_ENST00000413152.2_Silent_p.G901G|THSD7B_ENST00000272643.3_Silent_p.G932G|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AACCTTATGGAAACTGGTCAG	0.478000													19	129					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644850	20644850	+	RNA	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr15:20644850G>A	ENST00000428453.1	-	0	3097																		p.A803V(4)		central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CATGTCCCTCGCCCTTTCGGT	0.463000													4	51					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099945	50099945	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:50099945G>A	ENST00000418929.2	+	4	2365	c.2353G>A	c.(2353-2355)Gcc>Acc	p.A785T		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	480							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCTTCTGGAGGCCGGGGGCCC	0.711000													3	16					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													4	25					0	0	1	0	0
DARS	1615	broad.mit.edu	37	2	136743008	136743008	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:136743008G>A	ENST00000264161.4	-	1	246	c.31C>T	c.(31-33)Cag>Tag	p.Q11*	AC093391.2_ENST00000444406.1_RNA|AC093391.2_ENST00000419808.1_RNA|AC093391.2_ENST00000438432.1_RNA|DARS_ENST00000537273.1_5'UTR	NM_001349.2	NP_001340.2	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	11					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(2)	15				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GGCTTCTCCTGACTCTTGCGG	0.687000													4	38					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590357	140590357	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:140590357C>T	ENST00000239450.2	+	1	2067	c.1878C>T	c.(1876-1878)acC>acT	p.T626T	PCDHB12_ENST00000541609.1_Silent_p.T289T	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		626	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGTGCGCACCGCCAGGCTGC	0.701000													16	110					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45462012	45462012	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr5:45462012T>G	ENST00000303230.4	-	3	1004	c.947A>C	c.(946-948)cAg>cCg	p.Q316P		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	316						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TACTAAGAACTGAAGACAACC	0.423000													8	41					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40541116	40541116	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chrX:40541116G>A	ENST00000324817.1	-	19	2563	c.2445C>T	c.(2443-2445)acC>acT	p.T815T	MED14_ENST00000496531.1_5'UTR	NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	815	Interaction with SREBF1.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGCTTCCCTTGGTGGTTCCAT	0.299000													10	30					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185156	130185156	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr12:130185156G>A	ENST00000422113.2	-	2	493	c.167C>T	c.(166-168)gCg>gTg	p.A56V		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	56						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGACGTCCGCGTTGTTGAT	0.557000													10	50					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123542661	123542661	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:123542661G>T	ENST00000334268.4	-	39	2314	c.1997C>A	c.(1996-1998)aCt>aAt	p.T666N	TRDN_ENST00000398178.3_Missense_Mutation_p.T674N			Q13061	TRDN_HUMAN	triadin	674					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		CACATCTTCAGTTCCTTCTAG	0.269000													4	18					0.150653	0.153749	1	1	0
RNF169	254225	broad.mit.edu	37	11	74546712	74546712	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr11:74546712C>A	ENST00000299563.4	+	6	1077	c.1064C>A	c.(1063-1065)tCa>tAa	p.S355*		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	355							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						AGCTCCCTTTCATCCTTGGCT	0.512000													8	100					0.0381472	0.0391996	1	1	0
MAPK8IP3	23162	broad.mit.edu	37	16	1811306	1811306	+	Splice_Site	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:1811306G>A	ENST00000250894.4	+	13	1693	c.1536_splice	c.e13+1	p.S512_splice	MAPK8IP3_ENST00000356010.5_Splice_Site_p.S506_splice	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	512					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						GTACAGAATCGGTACATCCAC	0.567000													17	85					0	0	1	0	0
HSD17B8	7923	broad.mit.edu	37	6	33173308	33173308	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:33173308G>C	ENST00000374662.3	+	4	499	c.472G>C	c.(472-474)Gta>Cta	p.V158L	HSD17B8_ENST00000469186.1_3'UTR	NM_014234.4	NP_055049.1	Q92506	DHB8_HUMAN	hydroxysteroid (17-beta) dehydrogenase 8	158			V -> L (in a breast cancer sample; somatic mutation).		estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity	p.V158L(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(2)	9					NADH(DB00157)	CAGTAGCATCGTAGGAAAGGT	0.537000													8	110					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471331	92471331	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr14:92471331T>A	ENST00000267622.4	-	11	3362	c.2989A>T	c.(2989-2991)Aca>Tca	p.T997S		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	997					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TGAACTTTTGTTTCTTGAAAA	0.318000			T	PDGFRB	AML								5	108					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99762293	99762293	+	Splice_Site	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:99762293G>T	ENST00000370185.3	+	3	905		c.e3-1		LPPR4_ENST00000457765.1_Splice_Site	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN									phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TATCTTTGCAGATTATGGTAG	0.383000													14	192					1.52009e-12	1.71586e-12	1	1	0
COL7A1	1294	broad.mit.edu	37	3	48625824	48625824	+	Silent	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:48625824C>T	ENST00000328333.8	-	20	2708	c.2601G>A	c.(2599-2601)ccG>ccA	p.P867P	COL7A1_ENST00000454817.1_Silent_p.P867P	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	867	Fibronectin type-III 8.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCAGGGCTGGCGGAGCCTCAG	0.706000													3	14					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5170100	5170100	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr4:5170100G>A	ENST00000282908.5	+	3	605	c.183G>A	c.(181-183)gaG>gaA	p.E61E	STK32B_ENST00000510398.1_Silent_p.E14E|STK32B_ENST00000512636.1_Silent_p.E14E	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	61	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						AGTGCATCGAGAGGGATGAGG	0.517000													5	28					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966828	41966828	+	Silent	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr12:41966828G>T	ENST00000298919.7	+	10	1855	c.1467G>T	c.(1465-1467)ccG>ccT	p.P489P	PDZRN4_ENST00000539469.2_Silent_p.P491P|PDZRN4_ENST00000402685.2_Silent_p.P749P			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	749							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGTACTCCGCTCACTGTAG	0.493000													18	106					9.16793e-09	1.01187e-08	1	1	0
MTMR8	55613	broad.mit.edu	37	X	63488489	63488489	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chrX:63488489G>T	ENST00000374852.3	-	14	2110	c.2043C>A	c.(2041-2043)gaC>gaA	p.D681E	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	681						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AGATGCCCATGTCCCCAGAGA	0.527000													6	33					0.0215528	0.0223011	1	1	0
CNTN4	152330	broad.mit.edu	37	3	2944593	2944593	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:2944593A>G	ENST00000397461.1	+	11	1495	c.1111A>G	c.(1111-1113)Ata>Gta	p.I371V	CNTN4_ENST00000397459.2_Missense_Mutation_p.I43V|CNTN4_ENST00000427331.1_Missense_Mutation_p.I371V|CNTN4_ENST00000448906.2_Missense_Mutation_p.I43V|CNTN4_ENST00000358480.3_Missense_Mutation_p.I152V|CNTN4_ENST00000418658.1_Missense_Mutation_p.I371V|CNTN4_ENST00000475817.1_3'UTR	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	371	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AACACTCAACATAACAATAGT	0.373000													18	35					0	0	1	0	0
ANG	283	broad.mit.edu	37	14	21162089	21162089	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr14:21162089G>A	ENST00000336811.6	+	2	966	c.366G>A	c.(364-366)gcG>gcA	p.A122A	RNASE4_ENST00000555835.1_Intron|AL163636.6_ENST00000553909.1_RNA|RP11-903H12.3_ENST00000554286.1_lincRNA|RNASE4_ENST00000397995.2_Intron|ANG_ENST00000554073.1_Intron|ANG_ENST00000397990.4_Silent_p.A122A|RNASE4_ENST00000555597.1_Intron|RNASE4_ENST00000304704.4_Intron	NM_001145.4	NP_001136.1	P03950	ANGI_HUMAN	angiogenin, ribonuclease, RNase A family, 5	122					actin filament polymerization|activation of phospholipase A2 activity|activation of phospholipase C activity|activation of protein kinase B activity|angiogenesis|cell communication|cell death|cell migration|diacylglycerol biosynthetic process|homeostatic process|negative regulation of smooth muscle cell proliferation|negative regulation of translation|oocyte maturation|ovarian follicle development|placenta development|positive regulation of endothelial cell proliferation|positive regulation of phosphorylation|positive regulation of protein secretion|response to hormone stimulus|response to hypoxia|rRNA transcription	angiogenin-PRI complex|basal lamina|extracellular space|growth cone|neuronal cell body|nucleolus	actin binding|copper ion binding|heparin binding|pancreatic ribonuclease activity|peptide binding|receptor binding|rRNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)	5	all_cancers(95;0.00387)	all_cancers(140;0.196)|all_epithelial(140;0.156)	Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	OV - Ovarian serous cystadenocarcinoma(311;3.25e-17)|GBM - Glioblastoma multiforme(265;5.56e-07)		GAGCCACAGCGGGGTTCAGAA	0.517000													26	84					0	0	1	0	0
GAMT	2593	broad.mit.edu	37	19	1399013	1399013	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:1399013G>A	ENST00000447102.3	-	5	565	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C	GAMT_ENST00000252288.2_Missense_Mutation_p.R158C	NM_138924.2	NP_620279.1	Q14353	GAMT_HUMAN	guanidinoacetate N-methyltransferase	158					creatine biosynthetic process|muscle contraction	cytosol	guanidinoacetate N-methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|upper_aerodigestive_tract(1)	6		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Lung NSC(49;0.000195)|Breast(49;0.000231)|all_lung(49;0.000247)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Creatine(DB00148)	TTCAGCAGGCGAAAGGCGTGG	0.627000													7	50					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53279747	53279747	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:53279747C>G	ENST00000566029.1	+	15	3648	c.3439C>G	c.(3439-3441)Cca>Gca	p.P1147A	CHD9_ENST00000398510.3_Missense_Mutation_p.P1147A|CHD9_ENST00000447540.1_Missense_Mutation_p.P1147A|CHD9_ENST00000564845.1_Missense_Mutation_p.P1147A			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1147					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TTGTAATCATCCATATCTTAT	0.313000													9	31					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21973240	21973240	+	Silent	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:21973240G>A	ENST00000381418.4	-	19	5023	c.3543C>T	c.(3541-3543)gcC>gcT	p.A1181A	HR_ENST00000312841.8_Silent_p.A1126A	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	1181							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		ATGTCCCCACGGCCACCTTCA	0.567000													10	27					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62121936	62121936	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr20:62121936C>T	ENST00000217182.3	-	6	1090	c.925G>A	c.(925-927)Ggc>Agc	p.G309S	EEF1A2_ENST00000298049.7_Missense_Mutation_p.G309S	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	309						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			ACATTGAAGCCGACGTTGTCG	0.602000													19	129					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190250835	190250835	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:190250835T>A	ENST00000367462.3	-	3	513	c.282A>T	c.(280-282)agA>agT	p.R94S	RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_Intron|FAM5C_ENST00000534846.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		94						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CAAGGAAATTTCTTCTCTCAA	0.398000													24	90					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229100	20229100	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:20229100C>A	ENST00000418063.2	+	4	849	c.737C>A	c.(736-738)gCa>gAa	p.A246E	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	246						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						ACCCTTACTGCACATAAGAGA	0.368000													3	19					1	1	1	1	0
FRYL	285527	broad.mit.edu	37	4	48578177	48578177	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr4:48578177C>G	ENST00000537810.1	-	24	3195	c.2591G>C	c.(2590-2592)tGg>tCg	p.W864S	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.W864S|FRYL_ENST00000358350.4_Missense_Mutation_p.W864S|FRYL_ENST00000507711.1_Missense_Mutation_p.W864S			O94915	FRYL_HUMAN	FRY-like	864					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						ATAGTTTCTCCACAGGCCAAT	0.438000													19	97					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51101894	51101894	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:51101894C>T	ENST00000266037.9	+	6	354	c.331C>T	c.(331-333)Ctt>Ttt	p.L111F		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	111						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAAAGTAGATCTTTTCTACAA	0.408000													12	93					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959070	25959070	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr15:25959070C>T	ENST00000356865.6	-	10	2206	c.2095G>A	c.(2095-2097)Gat>Aat	p.D699N		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	699					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCGGCCTCATCCGGGCTCTCC	0.667000													17	55					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110438	106110438	+	RNA	SNP	G	G	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr14:106110438G>A	ENST00000390545.2	-	0	297																											CAACATTTGCGCTCTGCAGAG	0.602000													43	141					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123517884	123517884	+	Silent	SNP	T	T	C			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chrX:123517884T>C	ENST00000422452.2	-	30	6960	c.6897A>G	c.(6895-6897)acA>acG	p.T2299T	TENM1_ENST00000371130.3_Silent_p.T2292T|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AATACAGAGATGTAATCTCCG	0.438000													39	69					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196250051	196250051	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:196250051G>T	ENST00000367433.5	-	24	2878	c.2777C>A	c.(2776-2778)tCt>tAt	p.S926Y	KCNT2_ENST00000367431.4_Missense_Mutation_p.S876Y|KCNT2_ENST00000294725.8_Missense_Mutation_p.S950Y|KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	950						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ATCTCCAGTAGAAGAACACAA	0.323000													7	58					2.0095e-06	2.15407e-06	1	1	0
ENPP3	5169	broad.mit.edu	37	6	132059223	132059223	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr6:132059223A>T	ENST00000414305.1	+	24	2548	c.2220A>T	c.(2218-2220)agA>agT	p.R740S	ENPP3_ENST00000358229.5_3'UTR|ENPP3_ENST00000357639.3_Missense_Mutation_p.R740S			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	740	Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CCACAGAAAGAAATGGAGTAA	0.313000													15	69					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206480461	206480461	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr2:206480461G>T	ENST00000406610.2	+	23	3749	c.3542G>T	c.(3541-3543)cGt>cTt	p.R1181L	PARD3B_ENST00000349953.3_Missense_Mutation_p.R1080L|PARD3B_ENST00000351153.1_Missense_Mutation_p.R1112L|PARD3B_ENST00000358768.2_Missense_Mutation_p.R1119L|PARD3B_ENST00000488622.1_3'UTR	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1181					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCAGGGCCCCGTGGGGGCAGC	0.627000													16	101					7.05477e-17	8.27685e-17	1	1	0
SRSF4	6429	broad.mit.edu	37	1	29475219	29475221	+	In_Frame_Del	DEL	CTT	CTT	-	rs138237342	by1000genomes	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:29475219_29475221delCTT	ENST00000373795.4	-	6	1420_1422	c.1186_1188delAAG	c.(1186-1188)del	p.K396del	SRSF4_ENST00000546138.1_3'UTR|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	396	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						CAGTGTCTTCCTTCTTCTTCTTC	0.601													8	208	---	---	---	---					
DENND1B	163486	broad.mit.edu	37	1	197552285	197552285	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr1:197552285delC	ENST00000235453.4	-	15	1333	c.1056delG	c.(1054-1056)aafs	p.K352fs	DENND1B_ENST00000367396.3_Frame_Shift_Del_p.K382fs|DENND1B_ENST00000400967.2_Frame_Shift_Del_p.K352fs			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	382	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity	p.K352K(1)		NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						CTCTTACCTGCTTAAAAAGCT	0.403													21	80	---	---	---	---					
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs2622736	byFrequency	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr3:137880741_137880743delTCG	ENST00000260803.4	-	8	1776_1778	c.1623_1625delCGA	c.(1621-1626)gat>ga	p.DD541del	DBR1_ENST00000505015.2_In_Frame_Del_p.DD307del	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	541						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						TTAAGCTGCATCGTCATCATCAT	0.394													7	164	---	---	---	---					
KCNQ3	3786	broad.mit.edu	37	8	133150232	133150233	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr8:133150232_133150233insT	ENST00000388996.4	-	12	2019_2020	c.1599_1600insA	c.(1597-1602)aatcaafs	p.NQ533fs	KCNQ3_ENST00000519445.1_Frame_Shift_Ins_p.NQ533fs|KCNQ3_ENST00000521134.1_Frame_Shift_Ins_p.NQ413fs	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	533					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.F534I(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTCTCCTTGAATTTTTTTTTAT	0.455													9	201	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66545695	66545695	+	RNA	DEL	A	A	-			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr9:66545695delA	ENST00000445604.2	-	0	669																											CTGTAAGAGGAAAAAAAAACA	0.373													2	4	---	---	---	---					
GNG13	51764	broad.mit.edu	37	16	849043	849046	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr16:849043_849046delTCTT	ENST00000248150.4	-	2	133_136	c.32_35delAAGA	c.(31-36)agfs	p.KE11fs		NM_016541.2	NP_057625.1	Q9P2W3	GBG13_HUMAN	guanine nucleotide binding protein (G protein), gamma 13	11					cellular response to glucagon stimulus|energy reserve metabolic process		signal transducer activity			ovary(1)	1		Hepatocellular(780;0.00335)				GCTCTCCACCTCTTTCTTCATCTG	0.623													9	43	---	---	---	---					
LINC00482	284185	broad.mit.edu	37	17	79279019	79279020	+	RNA	INS	-	-	C	rs3215153	by1000genomes	TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr17:79279019_79279020insC	ENST00000332012.5	-	0	573_574					NR_038080.1																						CCCAGGCACAGCCCCTGAGGCA	0.673													6	10	---	---	---	---					
MBOAT7	79143	broad.mit.edu	37	19	54678110	54678111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr19:54678110_54678111insA	ENST00000245615.1	-	8	1526_1527	c.1046_1047insT	c.(1045-1047)actfs	p.T349fs	MBOAT7_ENST00000338624.6_Frame_Shift_Ins_p.T276fs|MBOAT7_ENST00000431666.2_Frame_Shift_Ins_p.T276fs	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	349					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGCTCAGCAGCATGGTCCAGGC	0.688													9	51	---	---	---	---					
AP001604.3	0	broad.mit.edu	37	21	28793489	28793490	+	RNA	INS	-	-	T	rs144948060		TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr21:28793489_28793490insT	ENST00000420186.2	-	0	202																											atttttttttcttttttttttt	0.347													3	6	---	---	---	---					
RP1-90G24.10	0	broad.mit.edu	37	22	32614394	32614401	+	RNA	DEL	AAAAAAAA	AAAAAAAA	-	rs72175023		TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chr22:32614394_32614401delAAAAAAAA	ENST00000434942.1	+	0	274																											actccctctcaaaaaaaaaaaaaaaaaa	0.385													2	4	---	---	---	---					
NONO	4841	broad.mit.edu	37	X	70511784	70511787	+	Frame_Shift_Del	DEL	TTCA	TTCA	-			TCGA-BA-A4II-01A-11D-A25Y-08	TCGA-BA-A4II-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2746527-5f39-47a2-ba05-4ff608616b57	887def3d-1332-4ddb-b05b-a79450f9e4f5	g.chrX:70511784_70511787delTTCA	ENST00000535149.1	+	2	686_689	c.43_46delTTCA	c.(43-48)ttfs	p.FI15fs	NONO_ENST00000373856.3_Frame_Shift_Del_p.FI104fs|NONO_ENST00000276079.8_Frame_Shift_Del_p.FI104fs|NONO_ENST00000373841.1_Frame_Shift_Del_p.FI104fs	NM_001145410.1	NP_001138882.1	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	104					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					AGGCGAAGTCTTCATTCATAAGGA	0.441			T	TFE3	papillary renal cancer								27	80	---	---	---	---					
