Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZFHX3	463	broad.mit.edu	37	16	72993190	72993190	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:72993190G>C	ENST00000268489.5	-	2	1527	c.855C>G	c.(853-855)ttC>ttG	p.F285L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	285					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GTTTGCACAAGAAACACATCA	0.498000													36	80					0	0	0.003271	0	0
EPHB3	2049	broad.mit.edu	37	3	184298946	184298946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184298946C>T	ENST00000330394.2	+	14	3177	c.2725C>T	c.(2725-2727)Cag>Tag	p.Q909*	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	909						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGCCAGCGCTCAGTCTGGGTT	0.572000													48	127					0	0	0.014410	0	0
LPIN1	23175	broad.mit.edu	37	2	11955216	11955216	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:11955216A>G	ENST00000256720.2	+	17	2237	c.2144A>G	c.(2143-2145)aAt>aGt	p.N715S	LPIN1_ENST00000404113.2_Missense_Mutation_p.N216S|LPIN1_ENST00000449576.2_Missense_Mutation_p.N800S|LPIN1_ENST00000425416.2_Missense_Mutation_p.N721S|LPIN1_ENST00000396097.1_Missense_Mutation_p.N445S|LPIN1_ENST00000396099.1_Missense_Mutation_p.N757S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	715	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TCTTTCAGGAATGGATATAAA	0.488000													18	36					0	0	0.006122	0	0
SDHA	6389	broad.mit.edu	37	5	225544	225544	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:225544A>G	ENST00000264932.6	+	4	438	c.323A>G	c.(322-324)aAt>aGt	p.N108S	SDHA_ENST00000504309.1_Missense_Mutation_p.N108S|SDHA_ENST00000510361.1_Intron	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	108					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	GGAGGAATCAATGCTGCTCTG	0.572000									Familial Paragangliomas				4	181					0	0	0.000602	0	0
TOB2	10766	broad.mit.edu	37	22	41832490	41832490	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:41832490C>G	ENST00000327492.3	-	2	1566	c.860G>C	c.(859-861)gGa>gCa	p.G287A		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	287				QGSGTPGPFGGSGAGTCNSSSFDMAQVFGGGANSLFLEKT -> RAAAPQARLEAVGLAPATAAALTWPRYLEVVPTASSWR RH (in Ref. 1; BAA10971).	female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						CCCACTGCCTCCAAACGGGCC	0.607000													25	24					0	0	0.003954	0	0
HUNK	30811	broad.mit.edu	37	21	33371383	33371383	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:33371383G>C	ENST00000270112.2	+	11	2391	c.2031G>C	c.(2029-2031)caG>caC	p.Q677H		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	677					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						AGCGCCATCAGAGTCTGCAGC	0.612000													30	63					0	0	0.006320	0	0
SPATA21	374955	broad.mit.edu	37	1	16757777	16757777	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:16757777C>G	ENST00000375577.1	-	2	429	c.90G>C	c.(88-90)aaG>aaC	p.K30N	SPATA21_ENST00000335496.1_Intron|SPATA21_ENST00000540400.1_Intron|SPATA21_ENST00000466212.1_5'UTR			Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	31							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		CACCAGCCCTCTTTATGGTGA	0.562000													16	22					0	0	0.004007	0	0
FTO	79068	broad.mit.edu	37	16	53844097	53844097	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:53844097C>G	ENST00000471389.1	+	2	313	c.91C>G	c.(91-93)Ctg>Gtg	p.L31V	FTO_ENST00000394647.3_5'UTR	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	31					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GCTCCCTTATCTGACCCCCAA	0.343000													21	43					0	0	0.010504	0	0
ZNF106	64397	broad.mit.edu	37	15	42743338	42743338	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743338G>C	ENST00000263805.4	-	2	1389	c.1063C>G	c.(1063-1065)Cag>Gag	p.Q355E	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		AGAGTCTTCTGAGAAGGGTAA	0.448000													49	60					0	0	0.014410	0	0
GALNTL5	168391	broad.mit.edu	37	7	151711769	151711769	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:151711769C>G	ENST00000392800.2	+	8	1321	c.1067C>G	c.(1066-1068)tCt>tGt	p.S356C	GALNTL5_ENST00000431418.2_Missense_Mutation_p.S356C	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	356	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		ATCCCCTGCTCTCGAGTAGGA	0.413000													34	52					0	0	0.013726	0	0
SLC34A2	10568	broad.mit.edu	37	4	25671434	25671434	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:25671434C>T	ENST00000382051.3	+	7	851	c.801C>T	c.(799-801)atC>atT	p.I267I	SLC34A2_ENST00000504570.1_Silent_p.I266I|SLC34A2_ENST00000503434.1_Silent_p.I266I	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	267					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGAAAGTCATCACTAAGCCCT	0.483000			T	ROS1	NSCLC								74	41					0	0	0.014410	0	0
MOB1B	92597	broad.mit.edu	37	4	71835700	71835700	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:71835700C>T	ENST00000309395.2	+	3	435	c.234C>T	c.(232-234)ttC>ttT	p.F78F	MOB1B_ENST00000396051.2_Silent_p.F83F|MOB1B_ENST00000511449.1_3'UTR	NM_001244766.1|NM_173468.3	NP_001231695.1|NP_775739.1	Q7L9L4	MOL1A_HUMAN	MOB kinase activator 1B	78					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding										TCACAGACTTCTGTACAGAAG	0.338000													3	29					0	0	0.004672	0	0
NRN1L	123904	broad.mit.edu	37	16	67920047	67920047	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67920047C>G	ENST00000339176.3	+	3	482	c.383C>G	c.(382-384)tCc>tGc	p.S128C	CTC-479C5.10_ENST00000572067.1_RNA|NRN1L_ENST00000576147.1_Missense_Mutation_p.P55A	NM_198443.1	NP_940845.1	Q496H8	NRN1L_HUMAN	neuritin 1-like	128						anchored to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GGCACAGGCTCCGAAACCAAC	0.667000													4	17					0	0	0.001168	0	0
KCNH2	3757	broad.mit.edu	37	7	150648119	150648119	+	Missense_Mutation	SNP	G	G	A	rs79624542		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:150648119G>A	ENST00000392968.2	-	6	2867	c.1747C>T	c.(1747-1749)Cgg>Tgg	p.R583W	KCNH2_ENST00000262186.5_Missense_Mutation_p.R679W|KCNH2_ENST00000330883.4_Missense_Mutation_p.R339W|KCNH2_ENST00000430723.3_Missense_Mutation_p.R679W			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	679					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCCCGCACCCGCAGCATCTGT	0.632000													27	32					0	0	0.006320	0	0
LOC220729	220729	broad.mit.edu	37	3	197349060	197349060	+	RNA	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:197349060C>T	ENST00000418868.1	-	0	517					NR_003266.2																						CCCATCACCTCGACCATGGCA	0.582000													29	32					0	0	0.003755	0	0
PARP10	84875	broad.mit.edu	37	8	145052088	145052088	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:145052088G>C	ENST00000313028.7	-	10	2812	c.2718C>G	c.(2716-2718)ttC>ttG	p.F906L	PARP10_ENST00000524918.1_Missense_Mutation_p.F897L|PARP10_ENST00000525773.1_Missense_Mutation_p.F918L	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	906	Myc binding.|PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCGGCCGCAGAAGCTGCGGT	0.721000													7	38					0	0	0.003080	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													4	239					0	0	0.009096	0	0
NDUFV3	4731	broad.mit.edu	37	21	44324239	44324239	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:44324239G>C	ENST00000354250.2	+	3	1186	c.1117G>C	c.(1117-1119)Gat>Cat	p.D373H	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AATCGTGGAAGATCAGATACC	0.572000													21	36					0	0	0.003330	0	0
PTPMT1	114971	broad.mit.edu	37	11	47587500	47587500	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:47587500G>C	ENST00000534775.1	+	1	491	c.326G>C	c.(325-327)cGa>cCa	p.R109P	PTPMT1_ENST00000326674.9_Missense_Mutation_p.E73Q|PTPMT1_ENST00000426530.2_Missense_Mutation_p.R109P|PTPMT1_ENST00000527079.2_3'UTR|NDUFS3_ENST00000533507.1_3'UTR|PTPMT1_ENST00000326656.8_Missense_Mutation_p.E73Q			Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	0	Tyrosine-protein phosphatase.				inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	6						CACCATGAACGAGGAGTACGA	0.677000													14	58					0	0	0.004990	0	0
PRX	57716	broad.mit.edu	37	19	40902497	40902497	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:40902497G>C	ENST00000324001.7	-	7	2032	c.1762C>G	c.(1762-1764)Cca>Gca	p.P588A	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	588	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCACCTTTGGAAGCTTCATC	0.567000													90	198					0	0	0.014410	0	0
NUFIP2	57532	broad.mit.edu	37	17	27613310	27613310	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:27613310C>G	ENST00000225388.4	-	2	1760	c.1702G>C	c.(1702-1704)Gag>Cag	p.E568Q	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	568						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			GTCCGTTTCTCCAGCTCGTAA	0.463000													12	84					0	0	0.013537	0	0
LRIG1	26018	broad.mit.edu	37	3	66432706	66432706	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:66432706C>G	ENST00000383703.3	-	17	3142	c.2539G>C	c.(2539-2541)Gag>Cag	p.E847Q	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_Missense_Mutation_p.E870Q			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	870						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CCATTGCTCTCAATGTGCCCA	0.567000													56	38					0	0	0.014410	0	0
ANK3	288	broad.mit.edu	37	10	61822996	61822996	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:61822996C>T	ENST00000280772.1	-	40	12659	c.12468G>A	c.(12466-12468)tcG>tcA	p.S4156S	ANK3_ENST00000373827.2_Silent_p.S1537S|ANK3_ENST00000355288.2_Silent_p.S677S|ANK3_ENST00000503366.1_Silent_p.S1544S	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4156	Death.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTCAAGACCGAAGTTAAGG	0.348000													12	15					0	0	0.001855	0	0
S100A4	6275	broad.mit.edu	37	1	153516241	153516241	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:153516241C>G	ENST00000368716.4	-	3	447	c.300G>C	c.(298-300)aaG>aaC	p.K100N	S100A4_ENST00000481009.1_5'UTR|S100A4_ENST00000368714.1_Missense_Mutation_p.K100N|S100A4_ENST00000368715.1_Missense_Mutation_p.K100N|S100A4_ENST00000354332.4_Missense_Mutation_p.K100N	NM_002961.2	NP_002952.1	P26447	S10A4_HUMAN	S100 calcium binding protein A4	100					epithelial to mesenchymal transition|positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus|perinuclear region of cytoplasm	calcium ion binding|RAGE receptor binding			large_intestine(2)|lung(1)|prostate(1)	4	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTTTTCATTTCTTCCTGGGCT	0.527000													85	274					0	0	0.014410	0	0
GCC2	9648	broad.mit.edu	37	2	109103017	109103017	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:109103017G>A	ENST00000309863.6	+	16	4557	c.3843G>A	c.(3841-3843)ctG>ctA	p.L1281L		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1281					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ACGAGCACCTGAAAACCTCTG	0.473000													50	79					0	0	0.014410	0	0
ZHX3	23051	broad.mit.edu	37	20	39831571	39831571	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:39831571C>G	ENST00000309060.3	-	4	2401	c.1986G>C	c.(1984-1986)gaG>gaC	p.E662D	ZHX3_ENST00000540170.1_Missense_Mutation_p.E662D|ZHX3_ENST00000432768.2_Missense_Mutation_p.E662D|ZHX3_ENST00000560361.1_Missense_Mutation_p.E662D|ZHX3_ENST00000559234.1_Missense_Mutation_p.E662D|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000544979.2_Missense_Mutation_p.E662D			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	662					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				TTTTCCGTCTCTCTGAAAACC	0.493000													103	182					0	0	0.014410	0	0
ARPC1B	10095	broad.mit.edu	37	7	98988657	98988657	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:98988657G>A	ENST00000451682.1	+	8	951	c.642G>A	c.(640-642)ggG>ggA	p.G214G	ARPC1B_ENST00000252725.5_Silent_p.G214G			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	214					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CAGCCAGCGGGAGCCGCGTGG	0.632000													16	47					0	0	0.004007	0	0
CAPN12	147968	broad.mit.edu	37	19	39234625	39234625	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:39234625C>T	ENST00000328867.4	-	1	489	c.181G>A	c.(181-183)Gac>Aac	p.D61N	CAPN12_ENST00000601953.1_Intron	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	61	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCCAGCTGGTCATAGCCAAGG	0.627000													22	36					0	0	0.012319	0	0
WDR35	57539	broad.mit.edu	37	2	20113939	20113939	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:20113939G>A	ENST00000345530.3	-	27	3369	c.3254C>T	c.(3253-3255)tCa>tTa	p.S1085L	WDR35_ENST00000281405.4_Missense_Mutation_p.S1074L|WDR35_ENST00000416055.2_Intron	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	1085										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAAGCTTTTGAACAAGTCCC	0.433000													30	53					0	0	0.009535	0	0
TTC30A	92104	broad.mit.edu	37	2	178482268	178482268	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:178482268C>G	ENST00000355689.4	-	1	1426	c.1162G>C	c.(1162-1164)Gag>Cag	p.E388Q	AC073834.3_ENST00000357045.4_RNA	NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	388					cell projection organization	cilium	binding			autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CGAAGCTGCTCAGTCAGCATC	0.463000													99	122					0	0	0.014410	0	0
HSD17B4	3295	broad.mit.edu	37	5	118865666	118865666	+	Silent	SNP	A	A	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:118865666A>C	ENST00000504811.1	+	22	2104	c.1920A>C	c.(1918-1920)acA>acC	p.T640T	HSD17B4_ENST00000509514.1_Silent_p.T353T|HSD17B4_ENST00000522415.1_3'UTR|HSD17B4_ENST00000414835.2_Silent_p.T475T|HSD17B4_ENST00000515320.1_Silent_p.T597T|HSD17B4_ENST00000256216.6_Silent_p.T615T|HSD17B4_ENST00000510025.1_Silent_p.T591T|HSD17B4_ENST00000513628.1_Silent_p.T478T	NM_001199291.1	NP_001186220.1	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	615	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(2)	25		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	CAGCTAAGACACCCTCTGAGG	0.378000													5	65					0	0	0.010729	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356015	40356015	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:40356015G>C	ENST00000310169.2	+	5	1057	c.918G>C	c.(916-918)acG>acC	p.T306T		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	306					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	ACATAGCCACGATGGCCCTGA	0.502000													56	216					0	0	0.014410	0	0
KYNU	8942	broad.mit.edu	37	2	143797996	143797996	+	Splice_Site	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:143797996G>A	ENST00000264170.4	+	13	1299		c.e13-1		KYNU_ENST00000409512.1_Splice_Site	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase						anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCATTCCACAGATCTTTAAGC	0.333000													21	50					0	0	0.004656	0	0
ZNF836	162962	broad.mit.edu	37	19	52659059	52659059	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:52659059G>C	ENST00000322146.8	-	5	2398	c.1877C>G	c.(1876-1878)tCa>tGa	p.S626*	CTC-471J1.8_ENST00000594362.1_RNA|ZNF836_ENST00000597252.1_Nonsense_Mutation_p.S626*	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTTATGATTTGAAAGGTTTCC	0.408000													77	141					0	0	0.014410	0	0
EPHB3	2049	broad.mit.edu	37	3	184295229	184295229	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184295229G>C	ENST00000330394.2	+	6	1905	c.1453G>C	c.(1453-1455)Gac>Cac	p.D485H	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	485	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGTCATCCTGGACTACGAGAT	0.602000													3	130					0	0	0.004672	0	0
SYNE2	23224	broad.mit.edu	37	14	64476717	64476717	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:64476717A>T	ENST00000358025.3	+	32	4841	c.4611A>T	c.(4609-4611)ttA>ttT	p.L1537F	SYNE2_ENST00000344113.4_Missense_Mutation_p.L1537F|SYNE2_ENST00000554584.1_Missense_Mutation_p.L1537F|SYNE2_ENST00000357395.3_5'UTR	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1537					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGGAGCTCTTAAAACAATATC	0.353000													18	32					0	0	0.008871	0	0
ARMC4	55130	broad.mit.edu	37	10	28151401	28151401	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:28151401G>A	ENST00000305242.5	-	18	2853	c.2761C>T	c.(2761-2763)Cat>Tat	p.H921Y	ARMC4_ENST00000545014.1_Missense_Mutation_p.H446Y|ARMC4_ENST00000537576.1_Missense_Mutation_p.H613Y	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	921							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ACAACTCCATGATCTGTGATA	0.348000													50	90					0	0	0.014410	0	0
SRSF6	6431	broad.mit.edu	37	20	42086714	42086714	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:42086714G>C	ENST00000244020.3	+	1	147	c.41G>C	c.(40-42)cGg>cCg	p.R14P		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	14	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						TACAACGTCCGGGAGAAGGAC	0.647000													27	39					0	0	0.007291	0	0
ESRP1	54845	broad.mit.edu	37	8	95653588	95653588	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:95653588C>T	ENST00000433389.2	+	1	232	c.42C>T	c.(40-42)atC>atT	p.I14I	ESRP1_ENST00000423620.2_Silent_p.I14I|ESRP1_ENST00000358397.5_Silent_p.I14I|ESRP1_ENST00000454170.2_Silent_p.I14I	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	14					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TTTTTGGGATCACTGCTGGGG	0.587000													10	88					0	0	0.006214	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871400	51871400	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:51871400G>C	ENST00000371497.5	+	2	2290	c.1403G>C	c.(1402-1404)aGg>aCg	p.R468T	TSHZ2_ENST00000603338.2_Missense_Mutation_p.R465T|TSHZ2_ENST00000329613.6_Missense_Mutation_p.R465T	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	468					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAAAAAGAAAGGCCAGAGGAA	0.423000													56	96					0	0	0.014410	0	0
DHX16	8449	broad.mit.edu	37	6	30624384	30624384	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:30624384G>C	ENST00000376442.3	-	14	2496	c.2301C>G	c.(2299-2301)ctC>ctG	p.L767L	DHX16_ENST00000376437.5_Silent_p.L286L	NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	767	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CTAAGCTCTTGAGCAGCAACA	0.557000													73	102					0	0	0.014410	0	0
DCBLD2	131566	broad.mit.edu	37	3	98518387	98518387	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:98518387G>A	ENST00000326840.6	-	16	2519	c.2157C>T	c.(2155-2157)ctC>ctT	p.L719L	DCBLD2_ENST00000326857.9_Silent_p.L733L	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	719					cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						CAGTCCTGGAGAGAAGTGTAT	0.572000													67	253					0	0	0.014410	0	0
SHPK	23729	broad.mit.edu	37	17	3495440	3495440	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3495440C>G	ENST00000572705.1	-	3	479	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	TRPV1_ENST00000399759.3_Missense_Mutation_p.E69Q|TRPV1_ENST00000425167.2_Missense_Mutation_p.E69Q|TRPV1_ENST00000576351.1_Missense_Mutation_p.E69Q|TRPV1_ENST00000174621.6_Silent_p.V43V|TRPV1_ENST00000399756.4_Missense_Mutation_p.E69Q|TRPV1_ENST00000571088.1_Missense_Mutation_p.E69Q|TRPV1_ENST00000310522.5_Missense_Mutation_p.E69Q	NM_080704.3	NP_542435.2	Q9UHJ6	SHPK_HUMAN	sedoheptulokinase	0					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				COAD - Colon adenocarcinoma(5;0.0828)		GAGTCCAGCTCACCTTCCTCG	0.652000													13	25					0	0	0.002450	0	0
SEC24A	10802	broad.mit.edu	37	5	134060674	134060674	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:134060674G>A	ENST00000398844.2	+	23	3460	c.3172G>A	c.(3172-3174)Gag>Aag	p.E1058K		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	1058					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTAAGGGATGAGAGTCCAAT	0.318000													23	43					0	0	0.002780	0	0
ADGRG6	57211	broad.mit.edu	37	6	142689043	142689043	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:142689043C>G	ENST00000230173.6	+	3	917	c.441C>G	c.(439-441)atC>atG	p.I147M	GPR126_ENST00000367608.2_Missense_Mutation_p.I147M|GPR126_ENST00000367609.3_Missense_Mutation_p.I147M|GPR126_ENST00000296932.8_Missense_Mutation_p.I147M|GPR126_ENST00000545477.1_3'UTR	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	147	CUB.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CCAGCTACATCAGAGGTATGT	0.408000													17	33					0	0	0.008871	0	0
FAM46C	54855	broad.mit.edu	37	1	118165574	118165574	+	Silent	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:118165574C>A	ENST00000369448.3	+	2	331	c.84C>A	c.(82-84)gtC>gtA	p.V28V		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	28										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		TGCATGAGGTCCTCACTGAAG	0.557000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			14	64					1.49906e-05	1.53612e-05	0.002450	1	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	53					0	0	0.000602	0	0
GRIA2	2891	broad.mit.edu	37	4	158254442	158254442	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:158254442G>C	ENST00000296526.7	+	8	1417	c.1092G>C	c.(1090-1092)caG>caC	p.Q364H	GRIA2_ENST00000449365.1_Missense_Mutation_p.Q317H|GRIA2_ENST00000393815.2_Missense_Mutation_p.Q317H|GRIA2_ENST00000507898.1_Missense_Mutation_p.Q317H|GRIA2_ENST00000264426.9_Missense_Mutation_p.Q364H	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	364					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGTTTGACCAGAATGGAAAAA	0.358000													23	19					0	0	0.004656	0	0
CHST13	166012	broad.mit.edu	37	3	126260987	126260987	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:126260987A>T	ENST00000319340.2	+	3	642	c.592A>T	c.(592-594)Agg>Tgg	p.R198W		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	198					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CGCCTTCCAGAGGCGCTACGG	0.726000													9	11					0	0	0.010729	0	0
BCHE	590	broad.mit.edu	37	3	165548470	165548470	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:165548470C>T	ENST00000264381.3	-	2	518	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	118					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAACAGTCTTCACTGAGGTCA	0.388000													23	64					0	0	0.002780	0	0
IL36B	27177	broad.mit.edu	37	2	113780314	113780314	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:113780314G>C	ENST00000259213.4	-	6	539	c.432C>G	c.(430-432)ctC>ctG	p.L144L		NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	144					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						CCTTCTTCCTGAGATGGTGAT	0.438000													51	68					0	0	0.014410	0	0
MYBPH	4608	broad.mit.edu	37	1	203144777	203144777	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:203144777G>C	ENST00000255416.4	-	1	164	c.107C>G	c.(106-108)tCa>tGa	p.S36*		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	36					cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		GGTGGACTCTGATACTGCCAC	0.622000													85	218					0	0	0.014410	0	0
NPR1	4881	broad.mit.edu	37	1	153665640	153665640	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:153665640C>G	ENST00000368680.3	+	21	3562	c.3090C>G	c.(3088-3090)ttC>ttG	p.F1030L		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	1030					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TTGGTGGTTTCGAGCTGGAGC	0.552000													41	112					0	0	0.014410	0	0
ZNF318	24149	broad.mit.edu	37	6	43307216	43307216	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:43307216G>C	ENST00000361428.2	-	10	4597	c.4520C>G	c.(4519-4521)tCa>tGa	p.S1507*	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1507	Pro-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TGGCTGTGCTGAGGCCATGAT	0.532000													20	45					0	0	0.010504	0	0
ZFP36	7538	broad.mit.edu	37	19	39898586	39898586	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:39898586C>T	ENST00000597629.1	+	2	320	c.246C>T	c.(244-246)ttC>ttT	p.F82F	ZFP36_ENST00000248673.3_Silent_p.F76F|ZFP36_ENST00000594045.1_3'UTR			P26651	TTP_HUMAN	ZFP36 ring finger protein	76					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCCTGGCTTCGCACCGCTGG	0.706000													22	33					0	0	0.002780	0	0
EXD3	54932	broad.mit.edu	37	9	140249213	140249213	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:140249213T>C	ENST00000340951.4	-	9	965	c.770A>G	c.(769-771)aAc>aGc	p.N257S	EXD3_ENST00000342129.4_5'UTR	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	257					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						AATGGCCGCGTTGGGACACAG	0.697000													28	5					0	0	0.013726	0	0
OR52B2	255725	broad.mit.edu	37	11	6191434	6191434	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:6191434G>A	ENST00000530810.1	-	1	204	c.123C>T	c.(121-123)gtC>gtT	p.V41V	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTTTCCCAGGACTGCAGTGA	0.478000													34	17					0	0	0.013726	0	0
SLMAP	7871	broad.mit.edu	37	3	57743444	57743444	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:57743444C>T	ENST00000383718.3	+	1	164	c.66C>T	c.(64-66)gtC>gtT	p.V22V	SLMAP_ENST00000416870.1_5'UTR|SLMAP_ENST00000295952.3_Silent_p.V22V|SLMAP_ENST00000449503.2_Silent_p.V22V|SLMAP_ENST00000428312.1_Silent_p.V22V|SLMAP_ENST00000295951.3_Silent_p.V22V			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	22	Necessary for targeting to centrosomes (By similarity).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AGCGTCATGTCTACCTGGACG	0.572000													26	9					0	0	0.005443	0	0
MMP27	64066	broad.mit.edu	37	11	102562560	102562560	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102562560C>G	ENST00000260229.4	-	10	1570	c.1479G>C	c.(1477-1479)aaG>aaC	p.K493N		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	493					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		AGCTTAAACTCTTATGATACA	0.299000													32	585					0	0	0.010818	0	0
CSMD2	114784	broad.mit.edu	37	1	34258100	34258100	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:34258100C>G	ENST00000373381.4	-	11	1650	c.1474G>C	c.(1474-1476)Gat>Cat	p.D492H	CSMD2_ENST00000338325.1_Missense_Mutation_p.D100H	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	452	CUB 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCTCCAAATCAAACTCCTCA	0.552000													29	65					0	0	0.009535	0	0
ATP10B	23120	broad.mit.edu	37	5	160071214	160071214	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:160071214C>T	ENST00000327245.5	-	9	1645	c.799G>A	c.(799-801)Gag>Aag	p.E267K		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	267					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAAGACTCTCACAGCCAAAG	0.512000													28	54					0	0	0.009535	0	0
LRP6	4040	broad.mit.edu	37	12	12302048	12302048	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:12302048G>T	ENST00000261349.4	-	14	3110	c.3034C>A	c.(3034-3036)Ctg>Atg	p.L1012M	LRP6_ENST00000543091.1_Missense_Mutation_p.L1012M	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1012	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TGTATTTCCAGGTTCTGACTC	0.428000													94	147					1.41219e-46	1.53124e-46	0.014410	1	0
SPG11	80208	broad.mit.edu	37	15	44856881	44856881	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:44856881C>T	ENST00000261866.7	-	39	7031	c.7015G>A	c.(7015-7017)Gag>Aag	p.E2339K	SPG11_ENST00000535302.2_Missense_Mutation_p.E2226K|SPG11_ENST00000427534.2_Intron	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	2339					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCGTAGGCCTCAGCCACAATA	0.373000													27	38					0	0	0.006320	0	0
PIGS	94005	broad.mit.edu	37	17	26897883	26897883	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26897883C>T	ENST00000308360.7	-	3	648	c.273G>A	c.(271-273)gaG>gaA	p.E91E	PIGS_ENST00000395346.2_Silent_p.E83E|PIGS_ENST00000543734.1_Silent_p.E30E	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	91					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					TCAGAGGAATCTCTCTTTCAT	0.562000													5	134					0	0	0.000602	0	0
DCST2	127579	broad.mit.edu	37	1	155002952	155002952	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:155002952C>G	ENST00000368424.3	-	6	1033	c.975G>C	c.(973-975)ctG>ctC	p.L325L	DCST2_ENST00000295536.5_Silent_p.L325L	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	325						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGAAGCCCATCAGAGCCAGGG	0.662000													5	69					0	0	0.001168	0	0
USP11	8237	broad.mit.edu	37	X	47098752	47098752	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:47098752G>C	ENST00000377107.2	+	3	643	c.289G>C	c.(289-291)Gag>Cag	p.E97Q	USP11_ENST00000218348.3_Missense_Mutation_p.E140Q			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	140	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						CCCCACAGATGAGATAAACTG	0.562000													17	5					0	0	0.004990	0	0
MFAP3	4238	broad.mit.edu	37	5	153433244	153433244	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:153433244G>C	ENST00000436816.1	+	3	1279	c.1060G>C	c.(1060-1062)Gat>Cat	p.D354H	MFAP3_ENST00000439768.2_Missense_Mutation_p.D208H|MFAP3_ENST00000322602.5_Missense_Mutation_p.D354H	NM_001242336.1|NM_005927.4	NP_001229265.1|NP_005918.1	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3	354						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)	7	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		TAACTACAAAGATGGGGCATA	0.408000													25	36					0	0	0.006320	0	0
FAHD2B	151313	broad.mit.edu	37	2	97749505	97749505	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:97749505T>C	ENST00000414820.1	-	9	1202	c.932A>G	c.(931-933)aAc>aGc	p.N311S	FAHD2B_ENST00000440566.2_Missense_Mutation_p.N311S|FAHD2B_ENST00000272610.3_Missense_Mutation_p.N311S			Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing 2B	311							hydrolase activity|metal ion binding			kidney(5)|large_intestine(2)|lung(3)|skin(2)	12						CACCACCTTGTTGATGATGAC	0.567000													38	88					0	0	0.007835	0	0
ANK1	286	broad.mit.edu	37	8	41545690	41545690	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:41545690G>C	ENST00000396942.1	-	35	4325	c.4242C>G	c.(4240-4242)ctC>ctG	p.L1414L	ANK1_ENST00000396945.1_Silent_p.L1414L|ANK1_ENST00000289734.7_Silent_p.L1414L|ANK1_ENST00000379758.2_Silent_p.L1414L|ANK1_ENST00000265709.8_Silent_p.L1455L|ANK1_ENST00000347528.4_Silent_p.L1414L|ANK1_ENST00000352337.4_Silent_p.L1414L			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1414	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGCTGAGACCGAGGTGCTCTG	0.512000													76	43					0	0	0.014410	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41447266	41447266	+	RNA	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:41447266C>G	ENST00000599198.1	+	0	765					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TTTACAAAAACCTACAGGAAA	0.527000													18	144					0	0	0.006122	0	0
DNAH2	146754	broad.mit.edu	37	17	7623114	7623114	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:7623114G>A	ENST00000572933.1	+	2	1522	c.62G>A	c.(61-63)tGg>tAg	p.W21*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.W21*|DNAH2_ENST00000082259.3_Nonsense_Mutation_p.W21*|DNAH2_ENST00000570791.1_Nonsense_Mutation_p.W21*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	21	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGGCAAGCTGGTCAGGGCGG	0.617000													18	24					0	0	0.010504	0	0
NYAP1	222950	broad.mit.edu	37	7	100087172	100087172	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:100087172G>A	ENST00000423930.1	+	4	1987	c.1828G>A	c.(1828-1830)Gcc>Acc	p.A610T	NYAP1_ENST00000454988.1_Missense_Mutation_p.A553T|NYAP1_ENST00000300179.2_Missense_Mutation_p.A610T			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	610																	CCACGTCATCGCCAGCGCAGG	0.637000													35	95					0	0	0.004878	0	0
ZNF284	342909	broad.mit.edu	37	19	44591044	44591044	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:44591044G>C	ENST00000421176.3	+	5	1629	c.1413G>C	c.(1411-1413)ttG>ttC	p.L471F	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				CAGGTATTTTGAGACATAAGA	0.413000													33	37					0	0	0.013726	0	0
MAP3K7	6885	broad.mit.edu	37	6	91228236	91228236	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:91228236C>G	ENST00000369329.3	-	16	1731	c.1570G>C	c.(1570-1572)Gaa>Caa	p.E524Q	MAP3K7_ENST00000479630.1_5'UTR|MAP3K7_ENST00000369320.1_Missense_Mutation_p.E178Q|MAP3K7_ENST00000369325.3_Intron|MAP3K7_ENST00000369332.3_Missense_Mutation_p.E497Q|MAP3K7_ENST00000369327.3_Intron	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	524					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding	p.E497Q(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CAATGCTGTTCAAACACTGCC	0.289000													11	24					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179392320	179392320	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:179392320C>T	ENST00000589042.1	-	362	107757	c.107533G>A	c.(107533-107535)Gag>Aag	p.E35845K	TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26905K|TTN_ENST00000342992.6_Missense_Mutation_p.E33277K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26972K|TTN_ENST00000460472.2_Missense_Mutation_p.E26780K|TTN_ENST00000591111.1_Missense_Mutation_p.E34204K|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000590040.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34204							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTCATCTCAGTCATGCTG	0.478000													36	35					0	0	0.003271	0	0
SF1	7536	broad.mit.edu	37	11	64534668	64534668	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:64534668T>C	ENST00000377394.3	-	11	1756	c.1402A>G	c.(1402-1404)Aaa>Gaa	p.K468E	SF1_ENST00000422298.2_Silent_p.G351G|SF1_ENST00000377387.1_Silent_p.G591G|SF1_ENST00000227503.9_Silent_p.G466G|SF1_ENST00000334944.5_Silent_p.G466G|SF1_ENST00000377390.3_Silent_p.G466G|SF1_ENST00000433274.2_Silent_p.G440G	NM_201997.2	NP_973726.2	Q15637	SF01_HUMAN	splicing factor 1	0	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						CATTACCTTTTCCTTGATGCA	0.562000													40	61					0	0	0.011902	0	0
TOE1	114034	broad.mit.edu	37	1	45808853	45808853	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:45808853C>T	ENST00000372090.5	+	8	1595	c.1012C>T	c.(1012-1014)Cgg>Tgg	p.R338W	TOE1_ENST00000539779.1_Missense_Mutation_p.R258W|TOE1_ENST00000495703.1_3'UTR	NM_025077.3	NP_079353.3	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	338						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	11	Acute lymphoblastic leukemia(166;0.155)					CAAGCGGCGACGGCGACGACG	0.567000													81	129					0	0	0.014410	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349254	89349254	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:89349254C>G	ENST00000301030.4	-	9	4156	c.3696G>C	c.(3694-3696)aaG>aaC	p.K1232N	ANKRD11_ENST00000378330.2_Missense_Mutation_p.K1232N	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1232	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GTTTATTTTTCTTATCTTGCG	0.443000													58	57					0	0	0.014410	0	0
FNDC3B	64778	broad.mit.edu	37	3	172070742	172070742	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:172070742G>A	ENST00000336824.4	+	22	2763	c.2664G>A	c.(2662-2664)ctG>ctA	p.L888L	FNDC3B_ENST00000415807.2_Silent_p.L888L|FNDC3B_ENST00000416957.1_Silent_p.L888L	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	888	Fibronectin type-III 7.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GCCTTGTACTGAACTGGGAAG	0.542000													31	95					0	0	0.004289	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349405	89349405	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:89349405C>T	ENST00000301030.4	-	9	4005	c.3545G>A	c.(3544-3546)aGa>aAa	p.R1182K	ANKRD11_ENST00000378330.2_Missense_Mutation_p.R1182K	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1182	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCTCCTGTCTCTGGGCTCCTT	0.542000													58	79					0	0	0.014410	0	0
VIPR2	7434	broad.mit.edu	37	7	158823439	158823439	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:158823439C>G	ENST00000262178.2	-	13	1370	c.1185G>C	c.(1183-1185)ccG>ccC	p.P395P	VIPR2_ENST00000377633.3_Silent_p.P379P|VIPR2_ENST00000402066.1_Silent_p.P536P	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	395					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CGGACGGGGTCGGGCACCGGC	0.706000													4	7					0	0	0.009096	0	0
BAIAP3	8938	broad.mit.edu	37	16	1388988	1388988	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:1388988G>C	ENST00000324385.5	+	3	480	c.322G>C	c.(322-324)Gag>Cag	p.E108Q	BAIAP3_ENST00000421665.2_Missense_Mutation_p.E73Q|BAIAP3_ENST00000397489.1_Missense_Mutation_p.E73Q|BAIAP3_ENST00000426824.3_Missense_Mutation_p.E73Q|BAIAP3_ENST00000397488.2_Missense_Mutation_p.E73Q|BAIAP3_ENST00000562208.1_Missense_Mutation_p.E73Q|BAIAP3_ENST00000568887.1_Missense_Mutation_p.E73Q	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	108					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GCCGTGCCTCGAGGTAAGGGT	0.667000													40	66					0	0	0.006230	0	0
TSKS	60385	broad.mit.edu	37	19	50247585	50247585	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:50247585C>G	ENST00000246801.3	-	8	1346	c.1264G>C	c.(1264-1266)Gag>Cag	p.E422Q	TSKS_ENST00000358830.3_Missense_Mutation_p.E222Q	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	422							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCGAACTCCTCCAGAATGGGT	0.597000													32	52					0	0	0.012213	0	0
EML5	161436	broad.mit.edu	37	14	89131807	89131807	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89131807C>T	ENST00000554922.1	-	22	3399	c.3151G>A	c.(3151-3153)Gat>Aat	p.D1051N	EML5_ENST00000380664.5_Missense_Mutation_p.D1051N|EML5_ENST00000352093.5_Missense_Mutation_p.D1013N	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1051						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTTTACCATCAGGAGAAAAA	0.413000													33	57					0	0	0.005524	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26666552	26666552	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26666552C>T	ENST00000226225.2	+	2	272	c.5C>T	c.(4-6)tCg>tTg	p.S2L	TNFAIP1_ENST00000583213.1_Intron|TNFAIP1_ENST00000544907.2_Intron	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	2					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CGGGAGATGTCGGGGGACACC	0.637000													17	31					0	0	0.004990	0	0
MED1	5469	broad.mit.edu	37	17	37564043	37564043	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:37564043C>T	ENST00000300651.6	-	17	4654	c.4431G>A	c.(4429-4431)caG>caA	p.Q1477Q	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	1477	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGGGACTATTCTGATAAGATT	0.453000										HNSCC(31;0.082)			27	95					0	0	0.006320	0	0
HHIPL2	79802	broad.mit.edu	37	1	222721362	222721362	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:222721362G>C	ENST00000343410.6	-	1	83	c.25C>G	c.(25-27)Ctg>Gtg	p.L9V		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	9					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		CCACCACACAGATTAGGAGTG	0.582000													23	47					0	0	0.004656	0	0
AUTS2	26053	broad.mit.edu	37	7	70227855	70227855	+	Splice_Site	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:70227855G>T	ENST00000342771.4	+	7	1063		c.e7-1		AUTS2_ENST00000406775.2_Splice_Site	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2											breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CTCCCATGCAGATCCGGAGTT	0.522000													44	225					2.24722e-20	2.40866e-20	0.014410	1	0
OR1B1	347169	broad.mit.edu	37	9	125391590	125391590	+	Silent	SNP	T	T	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:125391590T>G	ENST00000304833.3	-	1	262	c.225A>C	c.(223-225)ctA>ctC	p.L75L	RP11-64P14.7_ENST00000419604.1_RNA|RP11-64P14.7_ENST00000431442.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						TAACTGTGGATAGCCCCATGT	0.522000													48	10					0	0	0.014410	0	0
KRT39	390792	broad.mit.edu	37	17	39118663	39118663	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:39118663G>C	ENST00000355612.2	-	4	896	c.861C>G	c.(859-861)ttC>ttG	p.F287L	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	287	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				CCTGCGTGTTGAACCACTGTT	0.433000													243	2862					0	0	0.014410	0	0
IRAK3	11213	broad.mit.edu	37	12	66603284	66603284	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:66603284C>T	ENST00000261233.4	+	3	786	c.365C>T	c.(364-366)cCa>cTa	p.P122L	IRAK3_ENST00000457197.2_Missense_Mutation_p.P61L	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	122					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		GGTGGATTTCCAAATATATTA	0.353000													21	53					0	0	0.014323	0	0
HS3ST6	64711	broad.mit.edu	37	16	1961639	1961639	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:1961639G>A	ENST00000454677.2	-	2	1097	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	HS3ST6_ENST00000293937.3_Silent_p.F327F|HS3ST6_ENST00000443547.1_Silent_p.F296F			C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	296										endometrium(2)|lung(2)	4						ACCTGCGGTTGAAGGGCCGGT	0.701000													9	5					0	0	0.004482	0	0
ELOVL5	60481	broad.mit.edu	37	6	53138060	53138060	+	Silent	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:53138060A>G	ENST00000542638.1	-	6	1026	c.579T>C	c.(577-579)cgT>cgC	p.R193R	ELOVL5_ENST00000304434.6_Silent_p.R193R|ELOVL5_ENST00000370918.4_Silent_p.R183R|ELOVL5_ENST00000541407.1_Silent_p.R220R			Q9NYP7	ELOV5_HUMAN	ELOVL fatty acid elongase 5	193				YFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQL LQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTN FYIQTYNKKGASRR -> SVCADNHPDQLRGHLAVHIPSWL VVFPDWIHDFPDCSLHKLLHSDLQQERGLPKERPPEGPPEW VHGCCEWTHQQLFTPGKQCEAKEAAEGLKSKN (in Ref. 4; BAD93035).	fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7	Lung NSC(77;0.116)					AGAGGTATGGACGCATGGAAG	0.502000													3	119					0	0	0.009096	0	0
PPP2R3B	28227	broad.mit.edu	37	X	299609	299609	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:299609C>G	ENST00000390665.3	-	11	1392	c.1374G>C	c.(1372-1374)ctG>ctC	p.L458L		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	458					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGCAGCGCTTCAGGTCCTGCA	0.622000													26	111					0	0	0.007291	0	0
SGIP1	84251	broad.mit.edu	37	1	67109271	67109271	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:67109271G>A	ENST00000371037.4	+	7	405	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	SGIP1_ENST00000371035.3_Missense_Mutation_p.E67K|SGIP1_ENST00000371039.1_Missense_Mutation_p.E86K|SGIP1_ENST00000237247.6_Missense_Mutation_p.E114K|SGIP1_ENST00000371036.3_Missense_Mutation_p.E85K|SGIP1_ENST00000468286.1_3'UTR	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	110	Poly-Glu.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						ATCGGAAGAAGAAGAAGAATC	0.343000													22	39					0	0	0.012319	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507521	64507521	+	Silent	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:64507521G>T	ENST00000377494.1	-	5	1408	c.486C>A	c.(484-486)ctC>ctA	p.L162L	RASGRP2_ENST00000377497.3_Silent_p.L162L|RASGRP2_ENST00000354024.3_Silent_p.L162L|RASGRP2_ENST00000394432.3_Silent_p.L162L			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	162	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCAAGTAGGTGAGATGCTCCG	0.607000													12	82					5.16669e-11	5.45942e-11	0.010729	1	0
CEP250	11190	broad.mit.edu	37	20	34091370	34091370	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:34091370G>C	ENST00000397527.1	+	30	5893	c.5173G>C	c.(5173-5175)Gag>Cag	p.E1725Q	CEP250_ENST00000342580.4_Missense_Mutation_p.E1669Q	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1725	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CGGGAGCCTAGAGCACATGAA	0.577000													56	92					0	0	0.014410	0	0
PDS5A	23244	broad.mit.edu	37	4	39929692	39929692	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:39929692G>A	ENST00000303538.8	-	3	770	c.231C>T	c.(229-231)ttC>ttT	p.F77F	PDS5A_ENST00000503396.1_Silent_p.F77F	NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	77					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						TCCTGAGGAAGAATTCAGATG	0.423000													35	33					0	0	0.003755	0	0
PAIP1	10605	broad.mit.edu	37	5	43539098	43539098	+	Silent	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:43539098T>C	ENST00000306846.3	-	5	1006	c.774A>G	c.(772-774)aaA>aaG	p.K258K	PAIP1_ENST00000338972.4_Silent_p.K146K|PAIP1_ENST00000514514.1_Silent_p.K179K|PAIP1_ENST00000436644.2_Silent_p.K179K	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	258	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					CTTCATCCCCTTTTGCAGCTT	0.323000													3	171					0	0	0.009096	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62917013	62917013	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:62917013G>C	ENST00000253401.6	-	4	1353	c.553C>G	c.(553-555)Cta>Gta	p.L185V	ARHGEF9_ENST00000374870.4_Missense_Mutation_p.L83V|ARHGEF9_ENST00000374878.1_Missense_Mutation_p.L183V|ARHGEF9_ENST00000437457.2_Missense_Mutation_p.L132V|ARHGEF9_ENST00000495564.1_5'UTR|ARHGEF9_ENST00000374872.1_Missense_Mutation_p.L164V	NM_015185.2	NP_056000.1	O43307	ARHG9_HUMAN	Cdc42 guanine nucleotide exchange factor (GEF) 9	185	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|skin(1)	35						ACGTGCTCTAGGAAGCAGGGT	0.458000													16	2					0	0	0.004990	0	0
MFSD12	126321	broad.mit.edu	37	19	3542796	3542796	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:3542796C>G	ENST00000398558.4	-	10	1599	c.1600G>C	c.(1600-1602)Gac>Cac	p.D534H	C19orf71_ENST00000329493.5_Intron|MFSD12_ENST00000389395.3_Intron	NM_021731.2	NP_068377.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	0					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						GTCCCCCAGTCTTCCCTGGGC	0.612000													11	19					0	0	0.008291	0	0
CEP250	11190	broad.mit.edu	37	20	34090860	34090860	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:34090860C>G	ENST00000397527.1	+	30	5383	c.4663C>G	c.(4663-4665)Ctg>Gtg	p.L1555V	CEP250_ENST00000342580.4_Missense_Mutation_p.L1499V	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1555	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GTTGGTTACTCTGGAATGCCT	0.498000													27	82					0	0	0.013726	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070139	141070139	+	RNA	SNP	C	C	T	rs143443709	by1000genomes	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:141070139C>T	ENST00000503395.1	+	0	1219																		p.L85F(2)									CGGGCAGGTCCTCAGGCCAGA	0.667000													7	118					0	0	0.004482	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744048	135744048	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:135744048C>G	ENST00000375845.3	-	7	2424	c.2394G>C	c.(2392-2394)caG>caC	p.Q798H	MAP3K19_ENST00000358371.4_Missense_Mutation_p.Q685H|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Missense_Mutation_p.Q815H|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GGAATTCATTCTGTTTCATGG	0.393000													21	70					0	0	0.014323	0	0
OR1A2	26189	broad.mit.edu	37	17	3101343	3101343	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3101343C>T	ENST00000381951.1	+	1	531	c.531C>T	c.(529-531)ttC>ttT	p.F177F		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						TAGCCAATTTCTACTGTGACA	0.473000													57	93					0	0	0.014410	0	0
KIAA0100	9703	broad.mit.edu	37	17	26965349	26965349	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26965349G>A	ENST00000528896.2	-	13	1507	c.1433C>T	c.(1432-1434)tCc>tTc	p.S478F	KIAA0100_ENST00000389003.3_Missense_Mutation_p.S335F|KIAA0100_ENST00000544884.1_Missense_Mutation_p.S335F	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	478						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CTGAATGTGGGAGTCACTGCC	0.562000													28	42					0	0	0.006320	0	0
ZNF211	10520	broad.mit.edu	37	19	58146057	58146057	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:58146057G>C	ENST00000544273.1	+	4	514	c.187G>C	c.(187-189)Gat>Cat	p.D63H	ZNF211_ENST00000391703.3_5'UTR|ZNF211_ENST00000347302.3_Missense_Mutation_p.D51H|ZNF211_ENST00000240731.4_Missense_Mutation_p.D64H|ZNF211_ENST00000254182.7_5'UTR|ZNF211_ENST00000420680.1_Missense_Mutation_p.D55H|ZNF211_ENST00000541801.1_5'UTR|ZNF211_ENST00000299871.5_Missense_Mutation_p.D64H			Q13398	ZN211_HUMAN	zinc finger protein 211	51	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGATCTCCTTGATGAGGCTCA	0.498000													4	127					0	0	0.000602	0	0
RLF	6018	broad.mit.edu	37	1	40627251	40627251	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:40627251G>A	ENST00000372771.4	+	1	207	c.180G>A	c.(178-180)ctG>ctA	p.L60L		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	60					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGACAGAGCTGAGGGAGCAAG	0.657000													32	43					0	0	0.005524	0	0
BIRC2	329	broad.mit.edu	37	11	102233700	102233700	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102233700G>C	ENST00000227758.2	+	4	2468	c.1069G>C	c.(1069-1071)Gaa>Caa	p.E357Q	BIRC2_ENST00000532672.1_Missense_Mutation_p.E336Q|BIRC2_ENST00000530675.1_Missense_Mutation_p.E308Q|BIRC2_ENST00000527910.1_3'UTR	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	357					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		TCATCTTCTTGAACAGGTAAA	0.279000													8	184					0	0	0.004482	0	0
ZNF608	57507	broad.mit.edu	37	5	123974878	123974878	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:123974878G>C	ENST00000306315.5	-	8	4915	c.4480C>G	c.(4480-4482)Cag>Gag	p.Q1494E	ZNF608_ENST00000504926.1_Missense_Mutation_p.Q1067E|ZNF608_ENST00000513985.1_5'UTR	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1494						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCACCTGCTGAGAGGCAACA	0.423000													16	31					0	0	0.008871	0	0
MDGA2	161357	broad.mit.edu	37	14	47426688	47426688	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:47426688G>A	ENST00000426342.1	-	9	1830	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*	MDGA2_ENST00000439988.2_Nonsense_Mutation_p.Q591*|MDGA2_ENST00000399232.2_Nonsense_Mutation_p.Q660*|MDGA2_ENST00000357362.3_Nonsense_Mutation_p.Q362*	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	591	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GTGTATTCCTGAGAGTCAAAT	0.448000													39	67					0	0	0.010771	0	0
NCAN	1463	broad.mit.edu	37	19	19356217	19356217	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:19356217C>T	ENST00000252575.5	+	13	3631	c.3588C>T	c.(3586-3588)aaC>aaT	p.N1196N	NCAN_ENST00000538881.1_Silent_p.N647N	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1196	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGCGCTGGAACGATGTCCCCT	0.552000													21	56					0	0	0.002780	0	0
DBI	1622	broad.mit.edu	37	2	120128369	120128369	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:120128369G>A	ENST00000542275.1	+	3	448	c.364G>A	c.(364-366)Gag>Aag	p.E122K	DBI_ENST00000311521.4_Missense_Mutation_p.E78K|DBI_ENST00000535617.1_Missense_Mutation_p.E103K|DBI_ENST00000409094.1_Missense_Mutation_p.E78K|DBI_ENST00000393103.2_Missense_Mutation_p.E62K|DBI_ENST00000460901.1_3'UTR|DBI_ENST00000535757.1_Missense_Mutation_p.E78K|DBI_ENST00000355857.3_Missense_Mutation_p.E61K	NM_001178017.1	NP_001171488.1	P07108	ACBP_HUMAN	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	61					transport		benzodiazepine receptor binding|fatty-acyl-CoA binding			kidney(1)|lung(4)|skin(1)	6						TGCCTGGAATGAGCTGAAAGG	0.418000													14	27					0	0	0.003163	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39580799	39580799	+	RNA	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:39580799G>C	ENST00000432258.1	+	0	3388																											GGCTGCACAGGAGCTTCAGAT	0.572000													4	108					0	0	0.009096	0	0
KIAA1467	57613	broad.mit.edu	37	12	13221564	13221564	+	Splice_Site	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:13221564C>T	ENST00000197268.8	+	9	1407	c.1286_splice	c.e9-1	p.S429_splice		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	429						integral to membrane				NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TTATTTGCAGCCAGCCTACTC	0.418000													39	72					0	0	0.010771	0	0
DHX40	79665	broad.mit.edu	37	17	57679960	57679960	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:57679960C>T	ENST00000451169.2	+	18	2099	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	DHX40_ENST00000251241.4_Silent_p.F628F|DHX40_ENST00000425628.3_Silent_p.F551F			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	628							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CGGGCTATTTCAAAAATGTAG	0.328000													5	73					0	0	0.000602	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105912815	105912815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:105912815G>A	ENST00000393359.2	-	4	1462	c.1036C>T	c.(1036-1038)Cag>Tag	p.Q346*	TGFBRAP1_ENST00000258449.1_Nonsense_Mutation_p.Q346*			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	346					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						TTACAAACCTGAAATTTTTCC	0.428000													37	74					0	0	0.010771	0	0
DPEP2	64174	broad.mit.edu	37	16	68025794	68025794	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68025794G>C	ENST00000412757.2	-	6	1274	c.609C>G	c.(607-609)ttC>ttG	p.F203L	DPEP2_ENST00000572888.1_Missense_Mutation_p.F203L|DPEP2_ENST00000393847.1_Missense_Mutation_p.F203L			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	203					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CCAGCATGTAGAAGGTAGGTA	0.592000													28	58					0	0	0.007291	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150525982	150525982	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:150525982G>A	ENST00000271643.4	+	6	751	c.515G>A	c.(514-516)cGc>cAc	p.R172H	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.R172H|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.R172H|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.R172H|RP11-54A4.2_ENST00000442435.2_RNA	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	172					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CACCGGAACCGCAGGCACCCT	0.577000													5	153					0	0	0.001168	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844701	128844701	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:128844701C>T	ENST00000310343.9	-	20	2348	c.2349G>A	c.(2347-2349)ttG>ttA	p.L783L	ARHGAP32_ENST00000392657.3_Silent_p.L434L|ARHGAP32_ENST00000524655.1_Silent_p.L709L|ARHGAP32_ENST00000527272.1_Silent_p.L434L	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	783					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTGGTGGGCTCAAGTCAACAT	0.483000													25	10					0	0	0.003330	0	0
ITFG3	83986	broad.mit.edu	37	16	312520	312520	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:312520C>G	ENST00000399932.3	+	8	1390	c.939C>G	c.(937-939)ctC>ctG	p.L313L	ITFG3_ENST00000301678.3_Silent_p.L313L|ITFG3_ENST00000301679.2_Silent_p.L313L|ITFG3_ENST00000442458.2_Silent_p.L313L|ITFG3_ENST00000600536.1_Silent_p.L313L|ITFG3_ENST00000450082.2_Silent_p.L313L			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	313						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AGAGCATGCTCAATGCCACCA	0.652000													25	38					0	0	0.004656	0	0
ERCC3	2071	broad.mit.edu	37	2	128038127	128038127	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:128038127C>G	ENST00000493187.2	-	9	1694	c.1231G>C	c.(1231-1233)Gac>Cac	p.D411H	ERCC3_ENST00000285398.2_Missense_Mutation_p.D475H			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	475	Helicase ATP-binding.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		ACAATTTTGTCATCTTCGCGG	0.507000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				17	45					0	0	0.004990	0	0
TTN	7273	broad.mit.edu	37	2	179458787	179458787	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:179458787C>G	ENST00000589042.1	-	297	58557	c.58333G>C	c.(58333-58335)Gag>Cag	p.E19445Q	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E10505Q|TTN_ENST00000342992.6_Missense_Mutation_p.E16877Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E10572Q|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E10380Q|TTN_ENST00000591111.1_Missense_Mutation_p.E17804Q|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17804	Fibronectin type-III 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCTTCTCTAAAGCAAGT	0.438000													60	112					0	0	0.014410	0	0
RP11-383M4.6	0	broad.mit.edu	37	9	84549692	84549692	+	RNA	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:84549692C>T	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CCATGCCCCACAGGGATCCTG	0.498000													7	29					0	0	0.008291	0	0
IGSF10	285313	broad.mit.edu	37	3	151155107	151155107	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151155107C>G	ENST00000282466.3	-	6	7241	c.7242G>C	c.(7240-7242)agG>agC	p.R2414S	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2414	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAACTTTATTCCTAGCTGCAC	0.393000													62	131					0	0	0.014410	0	0
TOP3B	8940	broad.mit.edu	37	22	22317203	22317203	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:22317203C>G	ENST00000398793.2	-	12	1701	c.1267G>C	c.(1267-1269)Gac>Cac	p.D423H	TOP3B_ENST00000357179.5_Missense_Mutation_p.D423H|TOP3B_ENST00000413067.2_Missense_Mutation_p.D152H	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	423					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TACTTGCAGTCATGGCTGACC	0.612000													36	64					0	0	0.006230	0	0
PARP1	142	broad.mit.edu	37	1	226567800	226567800	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:226567800C>G	ENST00000366794.5	-	10	1509	c.1366G>C	c.(1366-1368)Gag>Cag	p.E456Q		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	456	Automodification domain.|BRCT.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		AGGAAGTCCTCAGACACAACT	0.488000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					18	48					0	0	0.007413	0	0
GALM	130589	broad.mit.edu	37	2	38893363	38893363	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:38893363G>A	ENST00000272252.5	+	1	312	c.60G>A	c.(58-60)gaG>gaA	p.E20E	GALM_ENST00000410063.1_Silent_p.E20E	NM_138801.2	NP_620156.1	Q96C23	GALM_HUMAN	galactose mutarotase (aldose 1-epimerase)	20					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding	p.E20E(1)		NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	14		all_hematologic(82;0.248)				GGACAGTGGAGAAGTTCCAGC	0.597000													15	42					0	0	0.002450	0	0
RNFT2	84900	broad.mit.edu	37	12	117217096	117217096	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:117217096C>T	ENST00000257575.4	+	7	1058	c.825C>T	c.(823-825)atC>atT	p.I275I	RNFT2_ENST00000319176.7_Intron|RNFT2_ENST00000407967.3_Silent_p.I275I|RNFT2_ENST00000392549.2_Silent_p.I275I			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	275						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		ACATCACCATCGCCCTCAAGT	0.552000													60	81					0	0	0.014410	0	0
HTR1F	3355	broad.mit.edu	37	3	88040493	88040493	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:88040493G>C	ENST00000319595.4	+	1	648	c.594G>C	c.(592-594)ttG>ttC	p.L198F		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	198					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CATTGATTTTGATCCTTTACT	0.408000													51	16					0	0	0.014410	0	0
ASAP3	55616	broad.mit.edu	37	1	23759683	23759683	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:23759683G>A	ENST00000336689.3	-	22	2254	c.2210C>T	c.(2209-2211)gCc>gTc	p.A737V	ASAP3_ENST00000495646.1_Missense_Mutation_p.A241V|ASAP3_ENST00000484906.1_5'UTR|ASAP3_ENST00000437606.2_Missense_Mutation_p.A728V	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	737					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						TCCCAGGCTGGCGACAGTCTC	0.602000													81	93					0	0	0.014410	0	0
UMODL1	89766	broad.mit.edu	37	21	43531075	43531075	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:43531075C>T	ENST00000400427.1	+	11	1923	c.1527C>T	c.(1525-1527)ctC>ctT	p.L509L	UMODL1_ENST00000400424.1_Silent_p.L509L|UMODL1_ENST00000408989.2_Silent_p.L581L|UMODL1_ENST00000408910.2_Silent_p.L581L	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	576	EGF-like 2; calcium-binding (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAGCAGCCCTCGGCCTAGAGA	0.657000													18	42					0	0	0.010504	0	0
PRSS50	29122	broad.mit.edu	37	3	46759219	46759219	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:46759219C>G	ENST00000460241.1	-	6	1766	c.96G>C	c.(94-96)ctG>ctC	p.L32L	PRSS50_ENST00000315170.7_Silent_p.L32L			Q9UI38	TSP50_HUMAN	protease, serine, 50	32					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						CTGCAGACCTCAGCAACAGAA	0.721000													6	2					0	0	0.001984	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68208741	68208741	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:68208741G>A	ENST00000262215.3	-	5	953	c.564C>T	c.(562-564)ctC>ctT	p.L188L		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	188					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCTGATTGATGAGATTTTTGC	0.378000													42	101					0	0	0.014410	0	0
RAC2	5880	broad.mit.edu	37	22	37637674	37637674	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:37637674G>A	ENST00000249071.6	-	2	181	c.60C>T	c.(58-60)ctC>ctT	p.L20L	RAC2_ENST00000405484.1_Silent_p.L13L|RAC2_ENST00000401529.3_Silent_p.L20L|RAC2_ENST00000406508.1_5'UTR	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	20					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGTAGCTGATGAGAAGGCAGG	0.622000													52	72					0	0	0.014410	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074441	76074441	+	RNA	SNP	A	A	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:76074441A>T	ENST00000395215.3	+	0	620																											CGAGCTGCAGAGAAGCGGTCC	0.557000													4	54					0	0	0.001168	0	0
ABL2	27	broad.mit.edu	37	1	179095631	179095631	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:179095631G>A	ENST00000502732.1	-	4	771	c.568C>T	c.(568-570)Cta>Tta	p.L190L	ABL2_ENST00000408940.3_Silent_p.L154L|ABL2_ENST00000511413.1_Silent_p.L190L|ABL2_ENST00000344730.3_Silent_p.L175L|ABL2_ENST00000512653.1_Silent_p.L175L|ABL2_ENST00000392043.3_Silent_p.L169L|ABL2_ENST00000504405.1_Silent_p.L154L|ABL2_ENST00000367623.4_Silent_p.L169L|ABL2_ENST00000507173.1_Silent_p.L169L	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	190	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCATTGATTAGACTGCTGAGC	0.537000			T	ETV6	AML								48	140					0	0	0.014410	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074431	76074431	+	RNA	SNP	C	C	T	rs149323153	by1000genomes	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:76074431C>T	ENST00000395215.3	+	0	610																		p.S190L(2)									CTCCAGTCCTCGAGCTGCAGA	0.547000													4	51					0	0	0.000602	0	0
MYPN	84665	broad.mit.edu	37	10	69881286	69881286	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:69881286G>T	ENST00000358913.5	+	2	579	c.91G>T	c.(91-93)Gag>Tag	p.E31*	MYPN_ENST00000354393.2_Intron|MYPN_ENST00000373675.3_Nonsense_Mutation_p.E31*|MYPN_ENST00000540630.1_Nonsense_Mutation_p.E31*	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	31	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GGGAAACAATGAGAGGAGTCG	0.522000													13	73					9.31168e-06	9.5682e-06	0.001855	1	0
OR1G1	8390	broad.mit.edu	37	17	3030534	3030534	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3030534G>T	ENST00000328890.2	-	1	341	c.312C>A	c.(310-312)ttC>ttA	p.F104L		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						CAAATAACATGAAAAAATACA	0.483000													10	82					0.000442599	0.0004523	0.006214	1	0
OR2A14	135941	broad.mit.edu	37	7	143826410	143826410	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:143826410G>A	ENST00000408899.2	+	1	260	c.205G>A	c.(205-207)Gac>Aac	p.D69N		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					GGCCATTGTTGACATATCCTA	0.463000													79	140					0	0	0.014410	0	0
ACSM1	116285	broad.mit.edu	37	16	20696551	20696551	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:20696551C>G	ENST00000307493.4	-	2	434	c.367G>C	c.(367-369)Gag>Cag	p.E123Q	ACSM1_ENST00000520010.1_Missense_Mutation_p.E123Q|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	123					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						AGCCACCACTCAGGAACTCGA	0.582000													22	74					0	0	0.012319	0	0
HIRIP3	8479	broad.mit.edu	37	16	30005773	30005773	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:30005773G>A	ENST00000279392.3	-	4	1523	c.693C>T	c.(691-693)atC>atT	p.I231I	HIRIP3_ENST00000564026.1_Intron	NM_003609.4	NP_003600.2	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	231	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(9)	17						TCTGGGCTAGGATCTCCTCTT	0.498000													6	230					0	0	0.003080	0	0
ZNF394	84124	broad.mit.edu	37	7	99097680	99097680	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:99097680C>T	ENST00000337673.6	-	1	240	c.37G>A	c.(37-39)Gac>Aac	p.D13N	ZNF394_ENST00000394177.3_Intron|ZNF789_ENST00000494186.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.D13N|ZNF789_ENST00000493485.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	13					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AACTCGGCGTCACTGCCGCGC	0.597000													52	48					0	0	0.014410	0	0
RFPL2	10739	broad.mit.edu	37	22	32590359	32590359	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:32590359C>G	ENST00000400237.1	-	3	1173	c.238G>C	c.(238-240)Gag>Cag	p.E80Q	RFPL2_ENST00000400236.3_5'UTR|RFPL2_ENST00000248983.4_Intron			O75678	RFPL2_HUMAN	ret finger protein-like 2	80							zinc ion binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	21						CCTCTGTCCTCCAGCTGCTTC	0.562000													15	23					0	0	0.006122	0	0
OR8H1	219469	broad.mit.edu	37	11	56058397	56058397	+	Missense_Mutation	SNP	T	T	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:56058397T>G	ENST00000313022.2	-	1	169	c.142A>C	c.(142-144)Ata>Cta	p.I48L		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					AGGCGGATTATCAATATCATC	0.423000													75	201					0	0	0.014410	0	0
ABCB11	8647	broad.mit.edu	37	2	169788945	169788945	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:169788945A>G	ENST00000263817.6	-	24	3279	c.3155T>C	c.(3154-3156)tTt>tCt	p.F1052S		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1052					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CAGCAGTTGAAAAAAGCGTGC	0.433000													8	10					0	0	0.003080	0	0
TRPV1	7442	broad.mit.edu	37	17	3495380	3495380	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3495380C>G	ENST00000174621.6	-	2	478	c.189G>C	c.(187-189)gaG>gaC	p.E63D	TRPV1_ENST00000399759.3_Missense_Mutation_p.D89H|TRPV1_ENST00000425167.2_Missense_Mutation_p.D89H|TRPV1_ENST00000576351.1_Missense_Mutation_p.D89H|TRPV1_ENST00000399756.4_Missense_Mutation_p.D89H|TRPV1_ENST00000571088.1_Missense_Mutation_p.D89H|TRPV1_ENST00000310522.5_Missense_Mutation_p.D89H|SHPK_ENST00000572705.1_Missense_Mutation_p.D89H			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	763					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GTGGGGCCGTCTCCTGGCCTC	0.657000													12	43					0	0	0.001855	0	0
MMP8	4317	broad.mit.edu	37	11	102592421	102592421	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102592421C>G	ENST00000236826.3	-	3	518	c.420G>C	c.(418-420)tgG>tgC	p.W140C		NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)	140					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATGCAACACTCCAGAGTTCAA	0.448000													21	350					0	0	0.012319	0	0
ACRC	93953	broad.mit.edu	37	X	70814205	70814205	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:70814205G>C	ENST00000373695.1	+	4	702	c.165G>C	c.(163-165)agG>agC	p.R55S	ACRC_ENST00000373696.3_Missense_Mutation_p.R55S			Q96QF7	ACRC_HUMAN	acidic repeat containing	55						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					TCCAGTCAAGGAGTGGTGACA	0.403000													32	8					0	0	0.006230	0	0
PARS2	25973	broad.mit.edu	37	1	55224213	55224213	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:55224213C>G	ENST00000371279.3	-	2	704	c.622G>C	c.(622-624)Gat>Cat	p.D208H		NM_152268.3	NP_689481.2	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase 2, mitochondrial (putative)	208					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			breast(1)|endometrium(3)|kidney(2)|lung(4)|ovary(2)|prostate(2)|skin(1)	15					L-Proline(DB00172)	GTGTACATATCCTTCATGTAA	0.552000													54	56					0	0	0.014410	0	0
CSDE1	7812	broad.mit.edu	37	1	115275262	115275262	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:115275262G>C	ENST00000438362.2	-	10	1529	c.1151C>G	c.(1150-1152)tCa>tGa	p.S384*	CSDE1_ENST00000358528.4_Nonsense_Mutation_p.S338*|CSDE1_ENST00000261443.5_Nonsense_Mutation_p.S307*|CSDE1_ENST00000530886.1_Nonsense_Mutation_p.S208*|CSDE1_ENST00000339438.6_Nonsense_Mutation_p.S307*|CSDE1_ENST00000534699.1_Nonsense_Mutation_p.S338*|CSDE1_ENST00000369530.1_Nonsense_Mutation_p.S353*	NM_001242891.1	NP_001229820.1	O75534	CSDE1_HUMAN	cold shock domain containing E1, RNA-binding	338	CSD 5.			IKCVDRDVRMFFHFSEILDGNQL -> HPSVWIRECSVCSF PLPVKFWMGTSS (in Ref. 2; AAD27787).	male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			NS(1)|breast(4)|endometrium(11)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	51	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATGTATTTGACAGAACTTC	0.373000													13	108					0	0	0.003163	0	0
UBXN1	51035	broad.mit.edu	37	11	62445293	62445293	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:62445293C>T	ENST00000294119.2	-	6	625	c.494G>A	c.(493-495)aGa>aAa	p.R165K	UBXN1_ENST00000524762.1_5'UTR|UBXN1_ENST00000533000.1_Missense_Mutation_p.R23K|UBXN1_ENST00000529640.1_Missense_Mutation_p.R161K|UBXN1_ENST00000301935.5_Missense_Mutation_p.R165K	NM_015853.3	NP_056937.2	Q04323	UBXN1_HUMAN	UBX domain protein 1	165	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding			endometrium(5)|lung(12)	17						GATCTTTTCTCTAACTCTTTG	0.433000													50	105					0	0	0.014410	0	0
TSSK2	23617	broad.mit.edu	37	22	19119070	19119070	+	Missense_Mutation	SNP	T	T	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:19119070T>G	ENST00000399635.2	+	1	750	c.158T>G	c.(157-159)gTg>gGg	p.V53G	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	53	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					ACTGACTTTGTGGAGAGATTC	0.498000													22	30					0	0	0.003330	0	0
NTRK2	4915	broad.mit.edu	37	9	87636301	87636301	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:87636301C>G	ENST00000376214.1	+	21	3404	c.2466C>G	c.(2464-2466)ctC>ctG	p.L822L	NTRK2_ENST00000376213.1_Silent_p.L806L|NTRK2_ENST00000277120.3_Silent_p.L822L|NTRK2_ENST00000323115.4_Silent_p.L806L	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	806					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TCCATACCCTCCTTCAGAACT	0.597000										TSP Lung(25;0.17)			88	16					0	0	0.014410	0	0
ACAD11	84129	broad.mit.edu	37	3	132345633	132345633	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:132345633C>G	ENST00000264990.6	-	9	2070	c.1099G>C	c.(1099-1101)Gat>Cat	p.D367H	ACAD11_ENST00000355458.3_Missense_Mutation_p.D367H|ACAD11_ENST00000481970.2_Missense_Mutation_p.D367H|ACAD11_ENST00000545291.1_5'UTR	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						CCAGTAGTATCAATCTGTGGT	0.338000													19	55					0	0	0.010504	0	0
PDK1	5163	broad.mit.edu	37	2	173429336	173429336	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:173429336C>G	ENST00000410055.1	+	4	616	c.516C>G	c.(514-516)gtC>gtG	p.V172V	PDK1_ENST00000544863.1_Silent_p.V17V|PDK1_ENST00000543905.1_Silent_p.V96V|PDK1_ENST00000282077.2_Silent_p.V172V|PDK1_ENST00000392571.2_Silent_p.V192V	NM_002610.3	NP_002601.1	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase, isozyme 1	172	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.12)			TGGATCCTGTCACCAGCCAGA	0.443000									Autosomal Dominant Polycystic Kidney Disease				26	55					0	0	0.004656	0	0
TYK2	7297	broad.mit.edu	37	19	10469922	10469922	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:10469922C>G	ENST00000525621.1	-	15	2585	c.2104G>C	c.(2104-2106)Gag>Cag	p.E702Q	TYK2_ENST00000264818.6_Missense_Mutation_p.E702Q|TYK2_ENST00000529370.1_Missense_Mutation_p.E702Q|TYK2_ENST00000524462.1_Missense_Mutation_p.E517Q	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	702	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TGGCCCCGCTCCCTCCGCAGC	0.637000													3	32					0	0	0.004672	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862469	25862469	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:25862469G>A	ENST00000397060.4	-	3	404	c.295C>T	c.(295-297)Cct>Tct	p.P99S	SLC17A3_ENST00000360657.3_Missense_Mutation_p.P99S|SLC17A3_ENST00000361703.6_Missense_Mutation_p.P99S	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	99					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						ACCTTTGCAGGAAGACTCTTT	0.383000													17	14					0	0	0.007413	0	0
YEATS2	55689	broad.mit.edu	37	3	183493896	183493896	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:183493896C>T	ENST00000305135.5	+	18	2757	c.2562C>T	c.(2560-2562)ctC>ctT	p.L854L		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	854					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTTACATCCTCAAGCAAACTC	0.438000													11	33					0	0	0.002450	0	0
GFOD2	81577	broad.mit.edu	37	16	67709325	67709325	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67709325C>G	ENST00000268797.7	-	3	1236	c.891G>C	c.(889-891)caG>caC	p.Q297H	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	297						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GCGGGACATCCTGGGGCCCCT	0.667000													5	74					0	0	0.001168	0	0
NSMAF	8439	broad.mit.edu	37	8	59522253	59522253	+	Silent	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:59522253T>C	ENST00000038176.3	-	10	809	c.597A>G	c.(595-597)aaA>aaG	p.K199K	NSMAF_ENST00000427130.2_Silent_p.K230K|NSMAF_ENST00000519858.1_5'UTR	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	199	GRAM.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				CCATTTCTGCTTTGCATTCCA	0.428000													57	32					0	0	0.014410	0	0
MTMR7	9108	broad.mit.edu	37	8	17228648	17228648	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:17228648G>C	ENST00000180173.5	-	3	242	c.208C>G	c.(208-210)Ctg>Gtg	p.L70V	MTMR7_ENST00000521857.1_Missense_Mutation_p.L70V	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	70							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		CGAATCAGCAGAGGGCATCCG	0.453000													6	94					0	0	0.001984	0	0
WNT9A	7483	broad.mit.edu	37	1	228113207	228113207	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:228113207C>T	ENST00000272164.5	-	2	119	c.109G>A	c.(109-111)Gag>Aag	p.E37K	WNT9A_ENST00000497852.1_5'UTR	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	37					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				GTCAGGGGCTCGCTGCCCGTC	0.711000													7	10					0	0	0.001984	0	0
FAM83E	54854	broad.mit.edu	37	19	49106753	49106753	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:49106753C>T	ENST00000263266.3	-	4	1363	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	392										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GGTCTCACCTCGTTGTCCCCA	0.706000													12	24					0	0	0.002450	0	0
PDGFA	5154	broad.mit.edu	37	7	552064	552064	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:552064C>G	ENST00000402802.3	-	3	596	c.189G>C	c.(187-189)ctG>ctC	p.L63L	PDGFA_ENST00000354513.5_Silent_p.L63L	NM_033023.4	NP_148983.1	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha polypeptide	63					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CGTGAGCTCTCAGGCTGGTGT	0.647000													26	79					0	0	0.013726	0	0
ODF2L	57489	broad.mit.edu	37	1	86818601	86818601	+	Missense_Mutation	SNP	C	C	G	rs149282656	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:86818601C>G	ENST00000359242.3	-	17	2115	c.1834G>C	c.(1834-1836)Gaa>Caa	p.E612Q	ODF2L_ENST00000317336.7_Missense_Mutation_p.E612Q|ODF2L_ENST00000370566.3_Missense_Mutation_p.E530Q|ODF2L_ENST00000394731.1_Missense_Mutation_p.E452Q|ODF2L_ENST00000370567.1_Missense_Mutation_p.E583Q|ODF2L_ENST00000294678.2_Missense_Mutation_p.E596Q	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like	612						centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		AGCTCAGTTTCCAGATCTAAT	0.279000													23	31					0	0	0.002780	0	0
SNHG14	104472715	broad.mit.edu	37	15	25349693	25349693	+	RNA	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:25349693C>G	ENST00000546682.1	+	0	2163				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						CTGCTGGTCTCCATGATTGAA	0.453000													2	3					0	0	0.004672	0	0
FAM19A3	284467	broad.mit.edu	37	1	113265703	113265703	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:113265703G>A	ENST00000369630.3	+	3	398	c.181G>A	c.(181-183)Gag>Aag	p.E61K	FAM19A3_ENST00000361886.3_Missense_Mutation_p.E61K			Q7Z5A8	F19A3_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A3	61						extracellular region		p.N56_R63delNRNRIEER(1)		lung(4)|ovary(1)	5	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACCGCATCGAGGAGCGCTC	0.657000													16	22					0	0	0.003163	0	0
C5orf51	285636	broad.mit.edu	37	5	41904484	41904484	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:41904484C>G	ENST00000381647.2	+	1	34	c.15C>G	c.(13-15)gtC>gtG	p.V5V	C5orf51_ENST00000505931.2_Intron	NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	5										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						CGGCCGCAGTCTCTAGTGTGG	0.667000													22	39					0	0	0.003954	0	0
CYFIP1	23191	broad.mit.edu	37	15	22997806	22997806	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:22997806G>C	ENST00000313077.7	+	27	3177	c.3052G>C	c.(3052-3054)Gaa>Caa	p.E1018Q	CYFIP1_ENST00000435939.2_Missense_Mutation_p.E587Q|CYFIP1_ENST00000560848.1_Missense_Mutation_p.E1018Q	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	1018					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GTCTTTAGAAGAAGTGTGTGA	0.527000													98	170					0	0	0.014410	0	0
DAB2IP	153090	broad.mit.edu	37	9	124530800	124530800	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:124530800C>G	ENST00000408936.3	+	10	1969	c.1787C>G	c.(1786-1788)tCc>tGc	p.S596C	DAB2IP_ENST00000309989.1_Missense_Mutation_p.S472C|DAB2IP_ENST00000259371.2_Missense_Mutation_p.S568C			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	596					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CTGGAGATCTCCAACCCCGAG	0.587000													5	141					0	0	0.001984	0	0
MFSD6	54842	broad.mit.edu	37	2	191362379	191362379	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:191362379C>G	ENST00000392328.1	+	7	2430	c.2106C>G	c.(2104-2106)ctC>ctG	p.L702L	MFSD6_ENST00000535751.1_Silent_p.L164L|MFSD6_ENST00000281416.7_Silent_p.L702L	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	702					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						TCTATGCACTCTACCAAATTA	0.463000													33	26					0	0	0.010818	0	0
RBBP8	5932	broad.mit.edu	37	18	20562197	20562197	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:20562197C>G	ENST00000399722.2	+	7	796	c.445C>G	c.(445-447)Caa>Gaa	p.Q149E	RBBP8_ENST00000327155.5_Missense_Mutation_p.Q149E|RBBP8_ENST00000399725.2_Missense_Mutation_p.Q149E|RBBP8_ENST00000360790.5_Missense_Mutation_p.Q149E|RBBP8_ENST00000585177.1_3'UTR	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	149					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TCAACAGCATCAAGCAGCTGA	0.403000								Homologous recombination					15	21					0	0	0.004007	0	0
GSTO1	9446	broad.mit.edu	37	10	106019428	106019428	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:106019428G>A	ENST00000539281.1	+	3	510	c.154G>A	c.(154-156)Ggt>Agt	p.G52S	GSTO1_ENST00000369710.4_Missense_Mutation_p.G80S|GSTO1_ENST00000369713.5_Missense_Mutation_p.G80S|GSTO1_ENST00000493946.1_3'UTR	NM_001191003.1	NP_001177932.1	P78417	GSTO1_HUMAN	glutathione S-transferase omega 1	80	GST N-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity			large_intestine(1)|lung(1)|stomach(1)	3		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AAACAGTCAGGGTCAGCTGAT	0.468000													43	63					0	0	0.010771	0	0
PPP1R2	5504	broad.mit.edu	37	3	195243706	195243706	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:195243706T>A	ENST00000328432.3	-	6	966	c.606A>T	c.(604-606)ttA>ttT	p.L202F		NM_006241.4	NP_006232.1	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 2	202					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			endometrium(2)|kidney(1)|large_intestine(1)|urinary_tract(2)	6	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		ATGAACTTCGTAATTTGTTTT	0.358000													29	27					0	0	0.003271	0	0
SHANK2	22941	broad.mit.edu	37	11	70332212	70332212	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:70332212G>T	ENST00000338508.4	-	32	4188	c.4189C>A	c.(4189-4191)Ctg>Atg	p.L1397M	SHANK2_ENST00000423696.2_Missense_Mutation_p.L1017M|SHANK2_ENST00000409161.1_Missense_Mutation_p.L800M|SHANK2_ENST00000449833.2_Missense_Mutation_p.L801M			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1017					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACGGATGCCAGAGGGGGAGGA	0.582000													34	457					4.92203e-23	5.29082e-23	0.006230	1	0
MTUS1	57509	broad.mit.edu	37	8	17613105	17613105	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:17613105G>A	ENST00000381869.3	-	2	685	c.212C>T	c.(211-213)tCt>tTt	p.S71F	MTUS1_ENST00000519263.1_Missense_Mutation_p.S71F|MTUS1_ENST00000381862.3_Missense_Mutation_p.S71F|MTUS1_ENST00000262102.6_Missense_Mutation_p.S71F	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	71						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle		p.S71Y(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		AAGGCTTAAAGAAATATTTTC	0.388000													6	76					0	0	0.001168	0	0
ARAP2	116984	broad.mit.edu	37	4	36130348	36130348	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:36130348G>C	ENST00000303965.4	-	21	3936	c.3447C>G	c.(3445-3447)atC>atG	p.I1149M		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1149	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCTTTTGATAGATATATTTGC	0.294000													25	44					0	0	0.003954	0	0
NLRC4	58484	broad.mit.edu	37	2	32476659	32476659	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32476659G>C	ENST00000404025.2	-	5	762	c.274C>G	c.(274-276)Cag>Gag	p.Q92E	NLRC4_ENST00000360906.5_Missense_Mutation_p.Q92E|NLRC4_ENST00000402280.1_Missense_Mutation_p.Q92E|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	92					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCTGATGTCTGATGAAAAAGA	0.433000													25	48					0	0	0.005443	0	0
FAM161A	84140	broad.mit.edu	37	2	62067353	62067353	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:62067353G>A	ENST00000404929.1	-	3	797	c.786C>T	c.(784-786)atC>atT	p.I262I	FAM161A_ENST00000405894.3_Silent_p.I262I	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	262					response to stimulus|visual perception	centrosome		p.I153I(1)|p.I262I(1)		breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTACCATTTCGATATCTGATT	0.393000													37	69					0	0	0.005524	0	0
TBX19	9095	broad.mit.edu	37	1	168281973	168281973	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:168281973C>T	ENST00000367821.3	+	8	1131	c.1080C>T	c.(1078-1080)agC>agT	p.S360S	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	360					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					GGACCATCAGCAATGGTGCCG	0.617000													35	83					0	0	0.006999	0	0
CSTF3	1479	broad.mit.edu	37	11	33182907	33182907	+	Translation_Start_Site	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:33182907G>C	ENST00000323959.4	-	0	104				CSTF3_ENST00000438862.2_De_novo_Start_OutOfFrame|CSTF3_ENST00000526480.1_5'UTR|CSTF3_ENST00000524827.1_De_novo_Start_OutOfFrame|CSTF3_ENST00000431742.2_De_novo_Start_OutOfFrame	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ACTGACCGTCGATGGGAAGCT	0.557000											OREG0020867	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	20					0	0	0.004656	0	0
CHD9	80205	broad.mit.edu	37	16	53260306	53260306	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:53260306G>C	ENST00000566029.1	+	5	2134	c.1925G>C	c.(1924-1926)aGa>aCa	p.R642T	CHD9_ENST00000564845.1_Missense_Mutation_p.R642T|CHD9_ENST00000447540.1_Missense_Mutation_p.R642T|CHD9_ENST00000398510.3_Missense_Mutation_p.R642T			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	642	Lys-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CAAATTAAAAGAAAAAAATAC	0.289000													16	24					0	0	0.003163	0	0
APOB	338	broad.mit.edu	37	2	21232316	21232316	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:21232316G>T	ENST00000233242.1	-	26	7551	c.7424C>A	c.(7423-7425)gCc>gAc	p.A2475D		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2475					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCAACTGTGGCCTTGGTTTC	0.418000													26	107					2.65835e-16	2.84116e-16	0.007291	1	0
RNF208	727800	broad.mit.edu	37	9	140114909	140114909	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:140114909C>T	ENST00000392827.1	-	2	924	c.756G>A	c.(754-756)cgG>cgA	p.R252R	RNF208_ENST00000391553.1_Silent_p.R252R			Q9H0X6	RN208_HUMAN	ring finger protein 208	252							zinc ion binding			lung(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		ACAGTGGGTTCCGCACGTGGC	0.701000													17	8					0	0	0.006122	0	0
LAMB1	3912	broad.mit.edu	37	7	107601753	107601753	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:107601753C>T	ENST00000393561.1	-	15	2263	c.2079G>A	c.(2077-2079)ccG>ccA	p.P693P	LAMB1_ENST00000393560.1_Silent_p.P669P|LAMB1_ENST00000222399.6_Silent_p.P669P			P07942	LAMB1_HUMAN	laminin, beta 1	669	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAAGCACACCGGCCGAGGAA	0.463000													9	55					0	0	0.008291	0	0
ITGB1BP2	26548	broad.mit.edu	37	X	70524109	70524109	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:70524109C>T	ENST00000538820.1	+	8	998	c.658C>T	c.(658-660)Cca>Tca	p.P220S	ITGB1BP2_ENST00000465388.1_3'UTR|ITGB1BP2_ENST00000373829.3_Missense_Mutation_p.P238S			Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein (melusin) 2	238	CS.				muscle organ development|signal transduction		SH3 domain binding			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)	14	Renal(35;0.156)					TGGCCAGATTCCACTTCCTGC	0.473000													46	13					0	0	0.014410	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467896	35467896	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:35467896C>G	ENST00000381151.3	+	2	911	c.399C>G	c.(397-399)ctC>ctG	p.L133L	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	133						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						CTCTGATTCTCTATATTTTCA	0.448000													92	170					0	0	0.014410	0	0
ME1	4199	broad.mit.edu	37	6	83921771	83921771	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:83921771G>A	ENST00000369705.3	-	14	1707	c.1591C>T	c.(1591-1593)Cct>Tct	p.P531S	ME1_ENST00000541327.1_Missense_Mutation_p.P365S|ME1_ENST00000543031.1_Missense_Mutation_p.P456S	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	531					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TGCGGTTCAGGATAAACTGTG	0.358000													32	56					0	0	0.004289	0	0
TMEM234	56063	broad.mit.edu	37	1	32682865	32682865	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:32682865C>G	ENST00000373593.1	-	4	343	c.323G>C	c.(322-324)gGa>gCa	p.G108A	TMEM234_ENST00000485689.1_5'UTR|TMEM234_ENST00000309777.6_Missense_Mutation_p.G108A|TMEM234_ENST00000344461.3_Missense_Mutation_p.G108A|TMEM234_ENST00000545122.1_Missense_Mutation_p.G108A			Q8WY98	TM234_HUMAN	transmembrane protein 234	108						integral to membrane				kidney(2)|lung(3)	5						CTTACGTTTTCCACCAATATC	0.522000													29	48					0	0	0.012213	0	0
UROC1	131669	broad.mit.edu	37	3	126219702	126219702	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:126219702G>A	ENST00000290868.2	-	11	1034	c.981C>T	c.(979-981)caC>caT	p.H327H	UROC1_ENST00000383579.3_Silent_p.H387H	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	327					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TGTCCAATTCGTGGACCAGGC	0.637000													23	40					0	0	0.003330	0	0
LATS1	9113	broad.mit.edu	37	6	150001095	150001095	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:150001095C>G	ENST00000543571.1	-	5	3056	c.2509G>C	c.(2509-2511)Gat>Cat	p.D837H	LATS1_ENST00000253339.5_Missense_Mutation_p.D837H|LATS1_ENST00000542747.1_5'UTR	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	837	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CCATCACGATCAATCAAAATA	0.363000													29	49					0	0	0.007291	0	0
MICAL2	9645	broad.mit.edu	37	11	12248645	12248645	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:12248645C>G	ENST00000256194.4	+	15	2250	c.1962C>G	c.(1960-1962)ctC>ctG	p.L654L	MICAL2_ENST00000379612.3_Silent_p.L654L|MICAL2_ENST00000537344.1_Silent_p.L654L|MICAL2_ENST00000342902.5_Silent_p.L654L|MICAL2_ENST00000527546.1_Silent_p.L654L	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	654						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding	p.L654L(1)		breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ATAACTATCTCAACCTCACAT	0.443000													15	7					0	0	0.008871	0	0
TTF1	7270	broad.mit.edu	37	9	135266215	135266215	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:135266215C>G	ENST00000334270.2	-	7	2030	c.1991G>C	c.(1990-1992)aGa>aCa	p.R664T		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	664	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACCACGATTTCTTTCTGTAGA	0.358000													107	26					0	0	0.014410	0	0
MMP1	4312	broad.mit.edu	37	11	102666324	102666324	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102666324G>A	ENST00000315274.6	-	5	707	c.640C>T	c.(640-642)Cgt>Tgt	p.R214C	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	214	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R214S(1)		breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GCTGCAACACGATGTAAGTTG	0.368000													15	168					0	0	0.003163	0	0
ZC3H14	79882	broad.mit.edu	37	14	89039315	89039315	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89039315G>A	ENST00000251038.5	+	6	1050	c.825G>A	c.(823-825)ccG>ccA	p.P275P	ZC3H14_ENST00000556945.1_Silent_p.P275P|ZC3H14_ENST00000555755.1_Silent_p.P275P|ZC3H14_ENST00000336693.4_Silent_p.P241P|ZC3H14_ENST00000557607.1_Silent_p.P120P|ZC3H14_ENST00000393514.5_Silent_p.P275P|ZC3H14_ENST00000359301.3_Silent_p.P241P|ZC3H14_ENST00000302216.8_Silent_p.P275P	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	275						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						CGTATAGTCCGTTCTTTAGAA	0.388000													4	80					0	0	0.000602	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37199482	37199482	+	RNA	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:37199482G>C	ENST00000425901.2	+	0	2635					NR_033753.2																						TGACAGAACTGAGCTTTGGAA	0.353000													93	285					0	0	0.014410	0	0
WDR81	124997	broad.mit.edu	37	17	1636853	1636853	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:1636853G>C	ENST00000409644.1	+	7	4522	c.4522G>C	c.(4522-4524)Gag>Cag	p.E1508Q	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Missense_Mutation_p.E147Q|WDR81_ENST00000437219.2_Missense_Mutation_p.E305Q|WDR81_ENST00000419248.1_Missense_Mutation_p.E281Q|WDR81_ENST00000309182.5_Missense_Mutation_p.E457Q|WDR81_ENST00000545662.1_Missense_Mutation_p.E139Q	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	281										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCCAACCACGAGCTGGTTGG	0.632000													75	122					0	0	0.014410	0	0
MED12L	116931	broad.mit.edu	37	3	151078367	151078367	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151078367C>T	ENST00000474524.1	+	19	2864	c.2826C>T	c.(2824-2826)ctC>ctT	p.L942L	MED12L_ENST00000273432.4_Silent_p.L802L|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	942					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTAGCCACCTCAGAAGTAAAT	0.428000													68	173					0	0	0.014410	0	0
KCNV1	27012	broad.mit.edu	37	8	110980590	110980590	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:110980590G>A	ENST00000524391.1	-	4	2262	c.1230C>T	c.(1228-1230)ttC>ttT	p.F410F	KCNV1_ENST00000297404.1_Silent_p.F410F			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	410						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATATACACATGAAGGCCACGA	0.478000													39	123					0	0	0.007835	0	0
PAK2	5062	broad.mit.edu	37	3	196554193	196554193	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:196554193G>C	ENST00000327134.3	+	14	1799	c.1477G>C	c.(1477-1479)Gaa>Caa	p.E493Q		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	493	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		TTCAGCCAAAGAATTATTACA	0.358000													41	82					0	0	0.008740	0	0
DDX51	317781	broad.mit.edu	37	12	132627321	132627321	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:132627321C>G	ENST00000397333.3	-	3	660	c.622G>C	c.(622-624)Gac>Cac	p.D208H		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	208					rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		TTCTGCAGGTCAGGATGGACG	0.617000													48	93					0	0	0.014410	0	0
HSPBAP1	79663	broad.mit.edu	37	3	122474119	122474119	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:122474119C>G	ENST00000306103.2	-	5	872	c.729G>C	c.(727-729)ctG>ctC	p.L243L	HSPBAP1_ENST00000465044.1_5'UTR|HSPBAP1_ENST00000383659.1_3'UTR	NM_024610.5	NP_078886.2	Q96EW2	HBAP1_HUMAN	HSPB (heat shock 27kDa) associated protein 1	243	JmjC.					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(114;0.0531)		GTCCTGGGCTCAGTGTAACCG	0.448000													19	55					0	0	0.008871	0	0
NUP85	79902	broad.mit.edu	37	17	73227442	73227442	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:73227442C>T	ENST00000447371.2	+	11	1022	c.598C>T	c.(598-600)Ctg>Ttg	p.L200L	NUP85_ENST00000541827.1_Silent_p.L322L|NUP85_ENST00000245544.4_Silent_p.L368L|NUP85_ENST00000579324.1_Silent_p.L256L|NUP85_ENST00000579298.1_Silent_p.L323L|NUP85_ENST00000540768.1_5'UTR			Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	368					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			CAGCATCGCCCTGAGCAACTG	0.582000													5	191					0	0	0.003080	0	0
CREB3L1	90993	broad.mit.edu	37	11	46341831	46341831	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:46341831C>G	ENST00000529193.1	+	11	1726	c.1275C>G	c.(1273-1275)ctC>ctG	p.L425L	CREB3L1_ENST00000534616.1_3'UTR|CREB3L1_ENST00000288400.3_Silent_p.L425L			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	425					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		CCCGAAGCCTCCTATTCTACG	0.617000			T	FUS	myxofibrosarcoma								13	29					0	0	0.001855	0	0
LATS1	9113	broad.mit.edu	37	6	149983190	149983190	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:149983190G>C	ENST00000543571.1	-	8	3615	c.3068C>G	c.(3067-3069)tCt>tGt	p.S1023C	LATS1_ENST00000253339.5_Missense_Mutation_p.S1023C	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	1023	AGC-kinase C-terminal.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		GTATGAAGCAGACTGCTGTCT	0.388000													14	107					0	0	0.002450	0	0
FLVCR1	28982	broad.mit.edu	37	1	213032530	213032530	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:213032530C>G	ENST00000366971.4	+	1	934	c.736C>G	c.(736-738)Cag>Gag	p.Q246E		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	246					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GCTGGGCAATCAGGTAAGTAC	0.562000													40	112					0	0	0.010771	0	0
NOD1	10392	broad.mit.edu	37	7	30492447	30492447	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:30492447C>T	ENST00000222823.4	-	6	1111	c.586G>A	c.(586-588)Gag>Aag	p.E196K	NOD1_ENST00000423334.2_Intron	NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	196	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						AAGATGGTCTCACCCTGCTCA	0.627000													42	13					0	0	0.007835	0	0
TMEM41A	90407	broad.mit.edu	37	3	185209541	185209541	+	Nonstop_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:185209541C>G	ENST00000296254.3	-	3	303	c.278G>C	c.(277-279)tGa>tCa	p.*93S	TMEM41A_ENST00000421852.1_Missense_Mutation_p.L193F|TMEM41A_ENST00000475480.1_Intron			Q96HV5	TM41A_HUMAN	transmembrane protein 41A	0						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TATATGGGATCAAACCTGGAA	0.423000													21	52					0	0	0.014323	0	0
TSHR	7253	broad.mit.edu	37	14	81610641	81610641	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:81610641C>T	ENST00000541158.2	+	11	2561	c.2239C>T	c.(2239-2241)Cta>Tta	p.L747L	TSHR_ENST00000298171.2_Silent_p.L747L|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	747					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity	p.L747I(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AAACTCCCATCTAACCCCAAA	0.408000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						38	67					0	0	0.009718	0	0
KLK2	3817	broad.mit.edu	37	19	51379884	51379884	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:51379884C>G	ENST00000325321.3	+	3	588	c.363C>G	c.(361-363)ctC>ctG	p.L121L	KLK2_ENST00000358049.4_Silent_p.L121L|KLK2_ENST00000391810.2_Silent_p.L19L			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	121	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GCCATGACCTCATGCTGCTCC	0.582000			T	ETV4	prostate								24	42					0	0	0.003330	0	0
PPP6R2	9701	broad.mit.edu	37	22	50854547	50854547	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:50854547G>A	ENST00000359139.3	+	6	973	c.579G>A	c.(577-579)caG>caA	p.Q193Q	PPP6R2_ENST00000216061.5_Silent_p.Q193Q|PPP6R2_ENST00000395741.3_Silent_p.Q193Q|PPP6R2_ENST00000395744.3_Silent_p.Q193Q	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	193						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						AGGTCATCCAGAGGCTTGTGG	0.517000													10	78					0	0	0.008291	0	0
ZBTB38	253461	broad.mit.edu	37	3	141161524	141161524	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:141161524C>G	ENST00000514251.1	+	4	573	c.294C>G	c.(292-294)gtC>gtG	p.V98V	ZBTB38_ENST00000321464.5_Silent_p.V99V|ZBTB38_ENST00000441582.2_Silent_p.V98V			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	98	BTB.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						CAGTCGTTGTCAAGAGACAGG	0.438000													8	64					0	0	0.004482	0	0
FBLN2	2199	broad.mit.edu	37	3	13670672	13670672	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:13670672G>T	ENST00000404922.3	+	13	2841	c.2722G>T	c.(2722-2724)Gag>Tag	p.E908*	FBLN2_ENST00000535798.1_Nonsense_Mutation_p.E887*|FBLN2_ENST00000492059.1_Nonsense_Mutation_p.E908*|FBLN2_ENST00000295760.7_Nonsense_Mutation_p.E861*	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	904	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGACGTGAATGAGTGTGAGAC	0.667000													16	9					1.33834e-09	1.39441e-09	0.007413	1	0
UPF2	26019	broad.mit.edu	37	10	12070767	12070767	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:12070767G>C	ENST00000356352.2	-	2	1595	c.1122C>G	c.(1120-1122)ctC>ctG	p.L374L	UPF2_ENST00000357604.5_Silent_p.L374L|UPF2_ENST00000397053.2_Silent_p.L374L			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	374	MIF4G 1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				CAGTATTCTGGAGCTCCCTGT	0.373000													37	43					0	0	0.007835	0	0
PLEC	5339	broad.mit.edu	37	8	144990596	144990596	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:144990596C>G	ENST00000322810.4	-	32	13973	c.13804G>C	c.(13804-13806)Gag>Cag	p.E4602Q	PLEC_ENST00000357649.2_Missense_Mutation_p.E4469Q|PLEC_ENST00000354958.2_Missense_Mutation_p.E4443Q|PLEC_ENST00000436759.2_Missense_Mutation_p.E4492Q|PLEC_ENST00000398774.2_Missense_Mutation_p.E4433Q|PLEC_ENST00000354589.3_Missense_Mutation_p.E4465Q|PLEC_ENST00000345136.3_Missense_Mutation_p.E4465Q|PLEC_ENST00000356346.3_Missense_Mutation_p.E4451Q|PLEC_ENST00000527096.1_Missense_Mutation_p.E4488Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4602	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCGGCAGCCTCCAGCAGCCGC	0.677000													57	151					0	0	0.014410	0	0
LRRC36	55282	broad.mit.edu	37	16	67405001	67405001	+	Translation_Start_Site	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67405001G>A	ENST00000541146.1	+	0	593				LRRC36_ENST00000563189.1_Silent_p.L329L|LRRC36_ENST00000329956.6_Silent_p.L450L|LRRC36_ENST00000435835.3_Silent_p.L329L|LRRC36_ENST00000290940.7_Silent_p.L182L			Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36											endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TGCGGACACTGCTGTTGTCTC	0.468000													44	70					0	0	0.010771	0	0
PDE4A	5141	broad.mit.edu	37	19	10574474	10574474	+	Silent	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:10574474C>A	ENST00000380702.2	+	15	1683	c.1683C>A	c.(1681-1683)ctC>ctA	p.L561L	PDE4A_ENST00000344979.3_Silent_p.L344L|PDE4A_ENST00000592685.1_Silent_p.L561L|PDE4A_ENST00000293683.5_Silent_p.L557L|PDE4A_ENST00000352831.6_Silent_p.L583L|PDE4A_ENST00000440014.2_Silent_p.L522L			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	583	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TGCAGGTCCTCCGGAACATGG	0.587000													33	62					1.414e-09	1.46914e-09	0.003755	1	0
SAMD8	142891	broad.mit.edu	37	10	76928341	76928341	+	Silent	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:76928341A>G	ENST00000542569.1	+	4	820	c.717A>G	c.(715-717)gtA>gtG	p.V239V	SAMD8_ENST00000372690.3_Silent_p.V302V|SAMD8_ENST00000372687.3_Silent_p.V239V	NM_001174156.1|NM_144660.2	NP_001167627.1|NP_653261.1	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	239					sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TGGGAACTGTATTCTTGCTTC	0.458000													82	136					0	0	0.014410	0	0
TTC27	55622	broad.mit.edu	37	2	32983539	32983539	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32983539G>C	ENST00000317907.4	+	13	1864	c.1633G>C	c.(1633-1635)Gag>Cag	p.E545Q		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	545							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						GGAGTTTCAAGAGTGTGTAGA	0.522000													34	60					0	0	0.013726	0	0
MED12L	116931	broad.mit.edu	37	3	151072985	151072985	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151072985C>G	ENST00000474524.1	+	16	2408	c.2370C>G	c.(2368-2370)ctC>ctG	p.L790L	MED12L_ENST00000273432.4_Silent_p.L650L|P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000491549.1_3'UTR	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	790					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCACTAAACTCCAGCTCCTTT	0.358000													32	63					0	0	0.008361	0	0
ZNF106	64397	broad.mit.edu	37	15	42743875	42743875	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743875G>C	ENST00000263805.4	-	2	852	c.526C>G	c.(526-528)Cac>Gac	p.H176D	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		CTATGGTTGTGAAACCAAGTC	0.468000													34	77					0	0	0.003271	0	0
COL9A2	1298	broad.mit.edu	37	1	40775622	40775622	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:40775622C>G	ENST00000372748.3	-	16	930	c.834G>C	c.(832-834)gaG>gaC	p.E278D		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	278	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CGTCACCCTTCTCCCCAGCTC	0.622000													50	81					0	0	0.014410	0	0
BCAN	63827	broad.mit.edu	37	1	156626846	156626846	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:156626846C>G	ENST00000329117.4	+	10	2503	c.2167C>G	c.(2167-2169)Ctg>Gtg	p.L723V	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	723	C-type lectin.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGGCGCGCATCTGGCCAGCAT	0.637000													29	86					0	0	0.009535	0	0
OCRL	4952	broad.mit.edu	37	X	128692624	128692624	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:128692624G>C	ENST00000371113.4	+	7	619	c.454G>C	c.(454-456)Gaa>Caa	p.E152Q	OCRL_ENST00000486673.1_3'UTR|OCRL_ENST00000357121.5_Missense_Mutation_p.E152Q	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	152					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						TCTTGGATTTGAAGACAATTT	0.408000													3	52					0	0	0.009096	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236757	33236757	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:33236757C>G	ENST00000401073.2	+	6	2047	c.1977C>G	c.(1975-1977)gtC>gtG	p.V659V	KIAA1522_ENST00000373481.3_Silent_p.V611V|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373480.1_Silent_p.V600V	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	600	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACAGGTTTGTCATACCTCCTC	0.632000													80	103					0	0	0.014410	0	0
MARK4	57787	broad.mit.edu	37	19	45783693	45783693	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:45783693G>A	ENST00000300843.4	+	11	1365	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	MARK4_ENST00000262891.4_Silent_p.K356K	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	356	UBA.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCAGCCAGAAGTACAACGAAG	0.607000													67	125					0	0	0.014410	0	0
PARD6G	84552	broad.mit.edu	37	18	77960666	77960666	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:77960666G>A	ENST00000353265.3	-	2	419	c.222C>T	c.(220-222)atC>atT	p.I74I	AC139100.3_ENST00000588950.1_RNA|PARD6G_ENST00000470488.2_Silent_p.I74I	NM_032510.3	NP_115899.1	Q9BYG4	PAR6G_HUMAN	par-6 family cell polarity regulator gamma	74	OPR.				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	8		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		CATCATTGTTGATGGGCAGCA	0.493000													6	108					0	0	0.001168	0	0
PLVAP	83483	broad.mit.edu	37	19	17487789	17487789	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:17487789C>G	ENST00000252590.4	-	1	370	c.309G>C	c.(307-309)ctG>ctC	p.L103L		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	103						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCGAGCATTCAGCCACATCT	0.622000													10	59					0	0	0.008291	0	0
ZNF347	84671	broad.mit.edu	37	19	53643671	53643671	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:53643671T>C	ENST00000452676.2	-	5	2839	c.2413A>G	c.(2413-2415)Agc>Ggc	p.S805G	ZNF347_ENST00000334197.7_Missense_Mutation_p.S804G|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.S805G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	804					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		GTAGTTAGGCTTGAACAGATA	0.418000													66	101					0	0	0.014410	0	0
KLHL12	59349	broad.mit.edu	37	1	202864773	202864773	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:202864773C>T	ENST00000367261.3	-	8	1230	c.1012G>A	c.(1012-1014)Gat>Aat	p.D338N	KLHL12_ENST00000367259.1_Missense_Mutation_p.D71N|KLHL12_ENST00000435533.3_Missense_Mutation_p.D376N	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	338					Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAACGGCCATCATAGCCACCA	0.507000													24	69					0	0	0.006320	0	0
MUC17	140453	broad.mit.edu	37	7	100679095	100679095	+	Silent	SNP	G	G	C	rs149059191	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:100679095G>C	ENST00000306151.4	+	3	4462	c.4398G>C	c.(4396-4398)ccG>ccC	p.P1466P		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1466	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAACACGCCGGTGGCCAATT	0.478000													161	432					0	0	0.014410	0	0
STAM	8027	broad.mit.edu	37	10	17737124	17737124	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:17737124C>T	ENST00000377524.3	+	7	827	c.612C>T	c.(610-612)ctC>ctT	p.L204L	STAM_ENST00000540523.1_Silent_p.L93L	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	204					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						CATCCAGTCTCTTAACTAACC	0.388000													30	51					0	0	0.003755	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529368	5529368	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:5529368G>T	ENST00000311659.4	-	2	1568	c.1421C>A	c.(1420-1422)cCt>cAt	p.P474H	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	474										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCCAGGGAGGCTCAGGGAT	0.552000													29	18					3.65163e-15	3.89159e-15	0.006320	1	0
GCNT2	2651	broad.mit.edu	37	6	10556812	10556812	+	Silent	SNP	C	C	T	rs55823251		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:10556812C>T	ENST00000316170.3	+	1	573	c.156C>T	c.(154-156)atC>atT	p.I52I	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000397423.2_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	53						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		CATCTTTTATCAATGGAAAAA	0.418000													45	30					0	0	0.014410	0	0
FAM63A	55793	broad.mit.edu	37	1	150972984	150972984	+	Silent	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:150972984G>C	ENST00000361936.5	-	6	1638	c.684C>G	c.(682-684)gtC>gtG	p.V228V	FAM63A_ENST00000361738.6_Silent_p.V276V|FAM63A_ENST00000493834.2_Silent_p.V133V|FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000312210.5_Silent_p.V86V	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	228							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCAGGTCAAAGACACTGCACT	0.527000													45	112					0	0	0.013114	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40268942	40268942	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:40268942G>A	ENST00000263791.5	+	12	2189	c.2146G>A	c.(2146-2148)Gag>Aag	p.E716K	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.E716K	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	716	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CACTTCGGGCGAGCGCTCGGC	0.716000													36	62					0	0	0.004878	0	0
EPHB3	2049	broad.mit.edu	37	3	184298534	184298534	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184298534C>T	ENST00000330394.2	+	13	2858	c.2406C>T	c.(2404-2406)atC>atT	p.I802I	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	802	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGATCCCCATCCGCTGGACTG	0.642000													15	76					0	0	0.004990	0	0
RBM12	10137	broad.mit.edu	37	20	34242517	34242517	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:34242517C>T	ENST00000374114.3	-	3	991	c.728G>A	c.(727-729)gGc>gAc	p.G243D	CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397442.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.G243D|CPNE1_ENST00000317619.3_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.G243D|CPNE1_ENST00000352393.4_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	243	Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGGCGGCATGCCCGACATGGG	0.552000													4	128					0	0	0.009096	0	0
OR14A16	284532	broad.mit.edu	37	1	247978846	247978846	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:247978846C>T	ENST00000357627.1	-	1	185	c.186G>A	c.(184-186)aaG>aaA	p.K62K		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AAGATAGATTCTTCAAGAAGA	0.418000													23	62					0	0	0.012319	0	0
LRRC30	339291	broad.mit.edu	37	18	7231387	7231387	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:7231387G>A	ENST00000383467.2	+	1	265	c.251G>A	c.(250-252)cGg>cAg	p.R84Q		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	84										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						AACCAGCTCCGGGTTCTCCCT	0.587000													23	45					0	0	0.002780	0	0
OCA2	4948	broad.mit.edu	37	15	28211914	28211914	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:28211914G>A	ENST00000354638.3	-	15	1713	c.1558C>T	c.(1558-1560)Ctc>Ttc	p.L520F	OCA2_ENST00000382996.2_Missense_Mutation_p.L520F|OCA2_ENST00000353809.5_Missense_Mutation_p.L496F	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	520					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CAGACCAGGAGAACAAGGCAA	0.483000									Oculocutaneous Albinism				13	23					0	0	0.013537	0	0
TAPBP	6892	broad.mit.edu	37	6	33272808	33272808	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:33272808G>A	ENST00000434618.2	-	4	1171	c.826C>T	c.(826-828)Cca>Tca	p.P276S	TAPBP_ENST00000475304.1_Missense_Mutation_p.P294S|TAPBP_ENST00000489157.1_Missense_Mutation_p.P189S|TAPBP_ENST00000456592.2_Missense_Mutation_p.P276S|TAPBP_ENST00000426633.2_Missense_Mutation_p.P276S	NM_003190.4|NM_172209.2	NP_003181.3|NP_757346.2	O15533	TPSN_HUMAN	TAP binding protein (tapasin)	276					antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			endometrium(2)|large_intestine(5)|lung(8)|ovary(3)	18						TGCAGGTATGGCAGGTGTATG	0.587000													108	138					0	0	0.014410	0	0
OR6N1	128372	broad.mit.edu	37	1	158735618	158735618	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:158735618G>A	ENST00000335094.2	-	1	874	c.855C>T	c.(853-855)ctC>ctT	p.L285L		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					TGAAGGGGTTGAGGAAGGGTG	0.517000													72	200					0	0	0.014410	0	0
PIAS3	10401	broad.mit.edu	37	1	145581458	145581458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:145581458C>T	ENST00000393045.2	+	9	1129	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	PIAS3_ENST00000369298.1_Nonsense_Mutation_p.Q312*	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	347					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGCCCACCTGCAGAGCTTCGA	0.507000													89	74					0	0	0.014410	0	0
ABRA	137735	broad.mit.edu	37	8	107782023	107782023	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:107782023C>T	ENST00000311955.3	-	1	450	c.396G>A	c.(394-396)gaG>gaA	p.E132E		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	132					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CAGCATCCCTCTCGTACCTGT	0.542000													62	155					0	0	0.014410	0	0
ATP10B	23120	broad.mit.edu	37	5	160049574	160049574	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:160049574C>G	ENST00000327245.5	-	14	2485	c.1639G>C	c.(1639-1641)Gat>Cat	p.D547H	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	547					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGTTTTTATCTGGAGTTACA	0.507000													45	65					0	0	0.014410	0	0
HSPA2	3306	broad.mit.edu	37	14	65008483	65008483	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:65008483G>C	ENST00000247207.6	+	1	1298	c.916G>C	c.(916-918)Gag>Cag	p.E306Q	HSPA2_ENST00000394709.1_Missense_Mutation_p.E306Q	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	306					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CGCCCGCTTCGAGGAGCTCAA	0.652000													10	19					0	0	0.008291	0	0
GTPBP6	8225	broad.mit.edu	37	X	221851	221851	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:221851C>T	ENST00000326153.4	-	6	753	c.754G>A	c.(754-756)Gag>Aag	p.E252K				O43824	GTPB6_HUMAN	GTP binding protein 6 (putative)	481						intracellular	GTP binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(3)	7		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				ACTGTGGCCTCCTTATACAGC	0.512000													37	12					0	0	0.007835	0	0
GOLGA3	2802	broad.mit.edu	37	12	133350895	133350895	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:133350895C>T	ENST00000204726.3	-	23	4713	c.4155G>A	c.(4153-4155)ccG>ccA	p.P1385P	GOLGA3_ENST00000450791.2_Silent_p.P1385P	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1385					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCTCGCCTTTCGGCTCCTTTC	0.617000													28	49					0	0	0.009535	0	0
OR2B6	26212	broad.mit.edu	37	6	27925541	27925541	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:27925541G>A	ENST00000244623.1	+	1	523	c.523G>A	c.(523-525)Gat>Aat	p.D175N		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CTATGTGATAGATCACTTTCT	0.483000													51	39					0	0	0.014410	0	0
KHDC1	80759	broad.mit.edu	37	6	73951446	73951446	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:73951446C>G	ENST00000370384.3	-	5	1020	c.520G>C	c.(520-522)Gag>Cag	p.E174Q	KHDC1_ENST00000257765.5_Missense_Mutation_p.E101Q|RP11-257K9.8_ENST00000423730.3_Intron	NM_001251874.1	NP_001238803.1	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	174						integral to membrane	RNA binding			large_intestine(1)|lung(4)|skin(1)	6						TCCAGCATCTCCAGGCCTGCA	0.582000													27	35					0	0	0.007291	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736827	140736827	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:140736827C>T	ENST00000571252.1	+	1	2060	c.2060C>T	c.(2059-2061)tCg>tTg	p.S687L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGACGACTCGGGCCTCACA	0.617000													25	40					0	0	0.012213	0	0
MZF1	7593	broad.mit.edu	37	19	59080894	59080894	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:59080894C>G	ENST00000215057.2	-	4	1200	c.640G>C	c.(640-642)Gag>Cag	p.E214Q	AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000594234.1_Missense_Mutation_p.E214Q|AC016629.8_ENST00000600726.1_RNA|MZF1_ENST00000594108.1_Missense_Mutation_p.E214Q|AC016629.8_ENST00000600534.1_RNA|MZF1_ENST00000599369.1_Missense_Mutation_p.E214Q	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	214					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TGGGCCTCCTCAGGCAGGAGG	0.597000													30	45					0	0	0.013726	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:7578212G>A	ENST00000420246.2	-	6	769	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_ENST00000445888.2_Nonsense_Mutation_p.R213*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R213*|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Nonsense_Mutation_p.R213*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R213*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R213*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(250)|p.R81*(21)|p.R120*(21)|p.0?(8)|p.?(5)|p.R213G(5)|p.R213fs*35(3)|p.R213fs*34(3)|p.D208_V216delDRNTFRHSV(1)|p.R120G(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R120fs*35(1)|p.R81G(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	8					0	0	0.005524	0	0
DNAAF1	123872	broad.mit.edu	37	16	84209596	84209596	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:84209596G>A	ENST00000378553.5	+	11	1880	c.1756G>A	c.(1756-1758)Gaa>Aaa	p.E586K	DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	586					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						CAGTGACCCTGAACTGGACTA	0.453000											OREG0023983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	69					0	0	0.010771	0	0
PMS2	5395	broad.mit.edu	37	7	6029573	6029573	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:6029573G>C	ENST00000265849.7	-	10	1107	c.1002C>G	c.(1000-1002)atC>atG	p.I334M	PMS2_ENST00000406569.3_Missense_Mutation_p.I334M|PMS2_ENST00000382321.4_Intron|PMS2_ENST00000469652.1_Intron|PMS2_ENST00000441476.2_Missense_Mutation_p.I228M	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	334					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GAGTAACATTGATATCAACGC	0.289000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				36	35					0	0	0.005524	0	0
EML5	161436	broad.mit.edu	37	14	89192964	89192964	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89192964G>C	ENST00000554922.1	-	8	1356	c.1108C>G	c.(1108-1110)Cgt>Ggt	p.R370G	EML5_ENST00000380664.5_Missense_Mutation_p.R370G|EML5_ENST00000352093.5_Missense_Mutation_p.R370G	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	370						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTGCACAACGAATTGGTTCT	0.368000													3	14					0	0	0.004672	0	0
DGCR5	26220	broad.mit.edu	37	22	18979430	18979430	+	RNA	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:18979430G>C	ENST00000438934.1	+	0	2781				DGCR5_ENST00000440005.2_RNA																							CGTCCTGGTGGAGTTCACCCT	0.577000													16	22					0	0	0.004990	0	0
IFNGR1	3459	broad.mit.edu	37	6	137540429	137540429	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:137540429C>G	ENST00000367739.4	-	1	157	c.36G>C	c.(34-36)caG>caC	p.Q12H	IFNGR1_ENST00000367735.2_5'UTR|IFNGR1_ENST00000478333.1_5'UTR	NM_000416.2	NP_000407.1	P15260	INGR1_HUMAN	interferon gamma receptor 1	12					regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	18	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TGCTCACACCCTGCATGACAA	0.692000													12	21					0	0	0.007413	0	0
TMEM40	55287	broad.mit.edu	37	3	12777058	12777058	+	Silent	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:12777058C>A	ENST00000314124.7	-	11	1034	c.678G>T	c.(676-678)ctG>ctT	p.L226L	TMEM40_ENST00000264728.8_Silent_p.L226L|TMEM40_ENST00000435218.2_Silent_p.L196L|TMEM40_ENST00000435575.1_Silent_p.L150L|TMEM40_ENST00000476331.1_5'UTR|TMEM40_ENST00000431022.2_Silent_p.L242L	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	226						integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						AGTTACCTGTCAGCCTAAACT	0.453000													7	69					2.74318e-10	2.87417e-10	0.006214	1	0
MOAP1	64112	broad.mit.edu	37	14	93650551	93650551	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:93650551T>C	ENST00000556883.1	-	2	521	c.37A>G	c.(37-39)Atg>Gtg	p.M13V	MOAP1_ENST00000298894.4_Missense_Mutation_p.M13V			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	13					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ttcatgtccatccccctgcac	0.507000													5	169					0	0	0.001984	0	0
LHFPL5	222662	broad.mit.edu	37	6	35773513	35773513	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:35773513G>A	ENST00000360215.1	+	1	443	c.66G>A	c.(64-66)tcG>tcA	p.S22S	LHFPL5_ENST00000373853.1_Silent_p.S22S	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	22						integral to membrane		p.S22S(1)		endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						TGCGGAACTCGCGAGCCGTGG	0.617000													30	122					0	0	0.009535	0	0
DLG2	1740	broad.mit.edu	37	11	84245714	84245714	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:84245714C>G	ENST00000398309.2	-	2	573	c.103G>C	c.(103-105)Gaa>Caa	p.E35Q	DLG2_ENST00000532653.1_Missense_Mutation_p.E35Q|DLG2_ENST00000376104.2_Missense_Mutation_p.E140Q|DLG2_ENST00000524982.1_Missense_Mutation_p.E35Q|DLG2_ENST00000543673.1_Missense_Mutation_p.E140Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	35						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CCTCTTACTTCGTGGGTTAGT	0.398000													47	83					0	0	0.014410	0	0
EVI2B	2124	broad.mit.edu	37	17	29632227	29632227	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:29632227G>C	ENST00000330927.4	-	2	555	c.401C>G	c.(400-402)tCt>tGt	p.S134C	NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|EVI2B_ENST00000577894.1_Missense_Mutation_p.S134C|EVI2B_ENST00000544462.1_Missense_Mutation_p.S149C	NM_006495.3	NP_006486.3	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	134						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTGTGTGGTAGAAGTACGGGC	0.448000													127	216					0	0	0.014410	0	0
LACE1	246269	broad.mit.edu	37	6	108616315	108616315	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:108616315T>C	ENST00000368977.4	+	1	218	c.32T>C	c.(31-33)cTg>cCg	p.L11P		NM_145315.3	NP_660358.2	Q8WV93	LACE1_HUMAN	lactation elevated 1	11							ATP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		TTGGTTACCCTGCGCCCCTTA	0.617000													3	49					0	0	0.004672	0	0
PLA2G15	23659	broad.mit.edu	37	16	68293433	68293433	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68293433G>T	ENST00000219345.5	+	6	1195	c.1112G>T	c.(1111-1113)tGc>tTc	p.C371F	PLA2G15_ENST00000566188.1_3'UTR|PLA2G15_ENST00000444212.2_Missense_Mutation_p.C171F|PLA2G15_ENST00000413021.2_Missense_Mutation_p.C277F|RP11-96D1.7_ENST00000563175.1_RNA	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	371					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						GCCCTGCAGTGCCAGGCCTGG	0.587000													21	40					2.89027e-11	3.0627e-11	0.014323	1	0
IGSF10	285313	broad.mit.edu	37	3	151155347	151155347	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151155347C>G	ENST00000282466.3	-	6	7001	c.7002G>C	c.(7000-7002)ctG>ctC	p.L2334L	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2334					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCGGTCTTCTCAGCATTTCCA	0.448000													67	178					0	0	0.014410	0	0
MYL9	10398	broad.mit.edu	37	20	35173441	35173441	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35173441G>T	ENST00000279022.2	+	2	258	c.154G>T	c.(154-156)Gag>Tag	p.E52*	MYL9_ENST00000346786.2_Nonsense_Mutation_p.E52*|RP5-977B1.7_ENST00000439595.1_RNA|RP5-977B1.7_ENST00000425233.1_RNA	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	52	EF-hand 1.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CATTGACAAGGAGGACCTGCA	0.542000													13	74					3.41278e-10	3.56574e-10	0.004990	1	0
CCSAP	126731	broad.mit.edu	37	1	229478177	229478177	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:229478177C>T	ENST00000284617.2	-	2	160	c.36G>A	c.(34-36)atG>atA	p.M12I	CCSAP_ENST00000452552.1_Missense_Mutation_p.M12I|CCSAP_ENST00000366687.1_Missense_Mutation_p.M12I|CCSAP_ENST00000483092.1_5'UTR	NM_145257.3	NP_660300.3			centriole, cilia and spindle-associated protein																		GGTAGCGCTTCATGTACTCGC	0.726000													10	32					0	0	0.001855	0	0
PRSS36	146547	broad.mit.edu	37	16	31153248	31153248	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:31153248C>G	ENST00000268281.4	-	11	1613	c.1555G>C	c.(1555-1557)Gag>Cag	p.E519Q	PRSS36_ENST00000569305.1_Missense_Mutation_p.E514Q|PRSS36_ENST00000418068.2_Missense_Mutation_p.E519Q	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	519	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						CAGGTCCCCTCCTCCTGGCAC	0.557000													46	89					0	0	0.014410	0	0
ZNF559	84527	broad.mit.edu	37	19	9453221	9453221	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:9453221C>G	ENST00000393883.2	+	6	1742	c.1094C>G	c.(1093-1095)tCt>tGt	p.S365C	ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000586255.1_Intron|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000603380.1_Missense_Mutation_p.S365C|ZNF559_ENST00000317221.7_3'UTR|ZNF177_ENST00000602856.1_Intron|ZNF177_ENST00000602738.1_Intron|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000538743.1_Missense_Mutation_p.S285C|ZNF559_ENST00000587557.1_Missense_Mutation_p.S429C	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TTTGCTAACTCTTCACATCTT	0.378000													13	23					0	0	0.013537	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857426	9857426	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:9857426G>A	ENST00000396573.2	-	14	4284	c.3975C>T	c.(3973-3975)taC>taT	p.Y1325Y	GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000330684.3_Silent_p.Y1325Y|GRIN2A_ENST00000396575.2_Silent_p.Y1325Y	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1325					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.Y1325Y(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACAGGCTGCCGTAAAAATTTC	0.527000													56	86					0	0	0.014410	0	0
FXYD5	53827	broad.mit.edu	37	19	35646421	35646421	+	Translation_Start_Site	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:35646421C>A	ENST00000342879.3	+	0	746				FXYD5_ENST00000392218.2_Intron|FXYD5_ENST00000541435.2_Intron|FXYD5_ENST00000590686.1_Intron|FXYD5_ENST00000588699.1_Intron|FXYD5_ENST00000543307.1_Intron|FXYD5_ENST00000392219.2_Intron|FXYD5_ENST00000423817.3_Intron			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5						microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TCACTGACATCATGGCTGACC	0.627000													12	51					7.03913e-09	7.27311e-09	0.013537	1	0
TRIB1	10221	broad.mit.edu	37	8	126445719	126445719	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:126445719G>A	ENST00000311922.3	+	2	1103	c.521G>A	c.(520-522)cGg>cAg	p.R174Q	TRIB1_ENST00000520847.1_Missense_Mutation_p.R8Q|TRIB1_ENST00000521778.1_3'UTR	NM_025195.2	NP_079471.1	Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1	174	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			GTGCGAAGCCGGAAGAGGCTG	0.572000													94	202					0	0	0.014410	0	0
PUF60	22827	broad.mit.edu	37	8	144902849	144902849	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:144902849G>C	ENST00000526683.1	-	5	890	c.335C>G	c.(334-336)tCa>tGa	p.S112*	PUF60_ENST00000524570.1_5'UTR|PUF60_ENST00000456095.2_Nonsense_Mutation_p.S83*|PUF60_ENST00000527197.1_Intron|PUF60_ENST00000453551.2_Nonsense_Mutation_p.S69*|PUF60_ENST00000349157.6_Intron|PUF60_ENST00000313352.7_Intron	NM_001271098.1|NM_078480.1	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	112	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TTGCAAAGGTGAGAGAGGATC	0.547000													78	246					0	0	0.014410	0	0
ZNF106	64397	broad.mit.edu	37	15	42743329	42743329	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743329G>A	ENST00000263805.4	-	2	1398	c.1072C>T	c.(1072-1074)Ctg>Ttg	p.L358L	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		TGTAAATCCAGAGTCTTCTGA	0.438000													49	63					0	0	0.014410	0	0
CFB	629	broad.mit.edu	37	6	31915793	31915793	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:31915793T>A	ENST00000556679.1	+	18	2393	c.2338T>A	c.(2338-2340)Tca>Aca	p.S780T	CFB_ENST00000456570.1_Missense_Mutation_p.S780T|CFB_ENST00000497841.1_3'UTR|CFB_ENST00000477310.1_Missense_Mutation_p.S629T|CFB_ENST00000425368.2_Missense_Mutation_p.S278T			P00751	CFAB_HUMAN	complement factor B	278					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GCTAGATGGATCAGACAGCAT	0.537000													30	42					0	0	0.007291	0	0
RBAK	57786	broad.mit.edu	37	7	5112576	5112576	+	Missense_Mutation	SNP	G	G	C	rs140476131		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:5112576G>C	ENST00000407184.1	+	8	725	c.459G>C	c.(457-459)gaG>gaC	p.E153D	RBAK_ENST00000498308.1_3'UTR|RBAK_ENST00000396904.2_3'UTR			Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	0					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		CGGAGACGGAGAGCTGCGGGC	0.657000													32	99					0	0	0.004878	0	0
GPR39	2863	broad.mit.edu	37	2	133402856	133402856	+	Missense_Mutation	SNP	T	T	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:133402856T>G	ENST00000329321.3	+	2	1508	c.1039T>G	c.(1039-1041)Tcc>Gcc	p.S347A	GPR39_ENST00000470071.1_3'UTR|LYPD1_ENST00000397463.2_3'UTR	NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	347						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTACACGGTGTCCTCGCAGCA	0.622000													23	72					0	0	0.006320	0	0
AP4E1	23431	broad.mit.edu	37	15	51233943	51233943	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:51233943G>C	ENST00000261842.5	+	10	1253	c.1147G>C	c.(1147-1149)Gat>Cat	p.D383H	AP4E1_ENST00000560508.1_Missense_Mutation_p.D308H	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	383					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TGAATGTTTAGATCATCCTGA	0.333000													14	38					0	0	0.001855	0	0
ZNF697	90874	broad.mit.edu	37	1	120165544	120165544	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:120165544G>A	ENST00000421812.2	-	3	1541	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F		NM_001080470.1	NP_001073939.1	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		AGAAGTCGCTGAAGCGCTTCT	0.647000													14	9					0	0	0.001855	0	0
CFAP54	144535	broad.mit.edu	37	12	97102560	97102560	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:97102560C>A	ENST00000524981.3	+	15	2056	c.2056C>A	c.(2056-2058)Cca>Aca	p.P686T				Q6ZTY8	CL063_HUMAN		660										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CAAGAGCAAACCAAACCTACC	0.348000													20	41					1.01871e-10	1.07339e-10	0.008871	1	0
ANAPC5	51433	broad.mit.edu	37	12	121756175	121756175	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:121756175C>T	ENST00000261819.3	-	15	1919	c.1798G>A	c.(1798-1800)Gcg>Acg	p.A600T	ANAPC5_ENST00000535482.1_Missense_Mutation_p.A266T|ANAPC5_ENST00000441917.2_Missense_Mutation_p.A488T|ANAPC5_ENST00000544314.1_5'UTR|ANAPC5_ENST00000344395.4_Missense_Mutation_p.A488T|ANAPC5_ENST00000541887.1_Missense_Mutation_p.A587T	NM_016237.4	NP_057321.2	Q9UJX4	APC5_HUMAN	anaphase promoting complex subunit 5	600					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATGGGCAGCGCGATGGTAGGG	0.552000													33	47					0	0	0.009535	0	0
JAG2	3714	broad.mit.edu	37	14	105609974	105609974	+	Splice_Site	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:105609974G>C	ENST00000331782.3	-	25	3489	c.3084_splice	c.e25-1	p.S1029_splice	JAG2_ENST00000347004.2_Splice_Site_p.S991_splice	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	1029					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AGGGCTGAAGGACTGCGGCAA	0.682000													5	60					0	0	0.001168	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34835329	34835329	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:34835329G>A	ENST00000192788.5	+	17	3825	c.3654G>A	c.(3652-3654)gaG>gaA	p.E1218E	UHRF1BP1_ENST00000452449.2_Silent_p.E1218E	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	1218										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						TGCAAGCAGAGGAACTGACCC	0.547000													40	89					0	0	0.006999	0	0
IFT80	57560	broad.mit.edu	37	3	159995223	159995223	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:159995223G>C	ENST00000326448.7	-	18	2402	c.1970C>G	c.(1969-1971)tCt>tGt	p.S657C	IFT80_ENST00000483465.1_Missense_Mutation_p.S520C|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.S828C|IFT80_ENST00000496589.1_Missense_Mutation_p.S520C	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	657						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGATTCTTTAGATGGAAGATT	0.318000													24	61					0	0	0.003954	0	0
VPS13C	54832	broad.mit.edu	37	15	62161820	62161820	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:62161820C>T	ENST00000261517.5	-	80	10700	c.10627G>A	c.(10627-10629)Gcc>Acc	p.A3543T	VPS13C_ENST00000249837.3_Missense_Mutation_p.A3500T|VPS13C_ENST00000395898.3_Missense_Mutation_p.A3500T|VPS13C_ENST00000395896.4_Missense_Mutation_p.A3543T	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3543					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TCCTTTTTGGCACCTTCAGAA	0.443000													4	132					0	0	0.009096	0	0
CABIN1	23523	broad.mit.edu	37	22	24483645	24483645	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:24483645G>A	ENST00000398319.2	+	23	3889	c.3504G>A	c.(3502-3504)ctG>ctA	p.L1168L	CABIN1_ENST00000405822.2_Silent_p.L1118L|CABIN1_ENST00000263119.5_Silent_p.L1168L	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1168					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GAGGCGAGCTGCCCCCTGAGC	0.567000													54	63					0	0	0.014410	0	0
MTRF1L	54516	broad.mit.edu	37	6	153311053	153311053	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:153311053C>G	ENST00000367233.5	-	7	1119	c.1120G>C	c.(1120-1122)Gaa>Caa	p.E374Q	MTRF1L_ENST00000464135.1_5'UTR|MTRF1L_ENST00000367231.5_3'UTR|MTRF1L_ENST00000367230.1_3'UTR	NM_019041.5	NP_061914.3	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor 1-like	374						mitochondrion	translation release factor activity, codon specific			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	10		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		GAAATAATTTCTACTAAAGAT	0.333000													37	80					0	0	0.014410	0	0
HBZ	3050	broad.mit.edu	37	16	202962	202962	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:202962C>T	ENST00000252951.2	+	1	277	c.54C>T	c.(52-54)atC>atT	p.I18I		NM_005332.2	NP_005323.1	P02008	HBAZ_HUMAN	hemoglobin, zeta	18						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GGGCCAAGATCTCCACGCAGG	0.622000													17	36					0	0	0.007413	0	0
RNF31	55072	broad.mit.edu	37	14	24617533	24617533	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:24617533G>T	ENST00000324103.6	+	3	726	c.406G>T	c.(406-408)Gaa>Taa	p.E136*	RNF31_ENST00000559275.1_5'UTR|RNF31_ENST00000557878.1_3'UTR	NM_017999.4	NP_060469.4	Q96EP0	RNF31_HUMAN	ring finger protein 31	136	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(4)|skin(2)|soft_tissue(1)	39				GBM - Glioblastoma multiforme(265;0.00861)		GAGCTTCCCCGAAGGGCAGGA	0.567000													14	38					7.93312e-07	8.17418e-07	0.002450	1	0
TNFRSF12A	51330	broad.mit.edu	37	16	3071626	3071626	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:3071626C>T	ENST00000575124.1	+	2	456	c.433C>T	c.(433-435)Cgt>Tgt	p.R145C	TNFRSF12A_ENST00000573001.1_Silent_p.F41F|TNFRSF12A_ENST00000341627.5_Silent_p.F55F|TNFRSF12A_ENST00000326577.4_Silent_p.F90F			Q9NP84	TNR12_HUMAN	tumor necrosis factor receptor superfamily, member 12A	0					angiogenesis|apoptosis	integral to membrane	receptor activity			lung(1)|skin(1)	2						GCCTGACCTTCGTGCTGGGGC	0.652000											OREG0023566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	41					0	0	0.008361	0	0
DHX34	9704	broad.mit.edu	37	19	47884111	47884111	+	Silent	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:47884111C>G	ENST00000328771.4	+	15	3370	c.3021C>G	c.(3019-3021)gtC>gtG	p.V1007V		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1007						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GGCTAGAAGTCCAGAACATGT	0.597000													30	44					0	0	0.008361	0	0
PIAS3	10401	broad.mit.edu	37	1	145581457	145581457	+	Silent	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:145581457G>T	ENST00000393045.2	+	9	1128	c.1038G>T	c.(1036-1038)ctG>ctT	p.L346L	PIAS3_ENST00000369298.1_Silent_p.L311L	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	346					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGCCCACCTGCAGAGCTTCG	0.507000													90	73					2.01383e-38	2.17727e-38	0.014410	1	0
ITCH	83737	broad.mit.edu	37	20	33001680	33001680	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:33001680C>T	ENST00000374864.4	+	6	683	c.470C>T	c.(469-471)tCa>tTa	p.S157L	ITCH_ENST00000262650.6_Missense_Mutation_p.S157L|ITCH_ENST00000535650.1_Missense_Mutation_p.S47L	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	157					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						ACTACATGTTCAGAAAGTAAG	0.328000													22	28					0	0	0.003954	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200818403	200818403	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:200818403G>C	ENST00000358823.2	+	11	2776	c.2506G>C	c.(2506-2508)Gat>Cat	p.D836H	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.D847H|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.D820H	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	847						cytoplasm|microtubule	protein binding										GTCACTGGCAGATATAAAAGA	0.453000													48	153					0	0	0.014410	0	0
TRIM43	129868	broad.mit.edu	37	2	96260159	96260159	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:96260159G>C	ENST00000272395.2	+	2	524	c.388G>C	c.(388-390)Gaa>Caa	p.E130Q		NM_001164464.1|NM_138800.1	NP_001157936.1|NP_620155.1	Q96BQ3	TRI43_HUMAN	tripartite motif containing 43	130						intracellular	zinc ion binding			breast(1)|large_intestine(3)|lung(7)|ovary(1)	12						CCATCCCATCGAAGAGGCAGC	0.488000													37	53					0	0	0.004878	0	0
SKI	6497	broad.mit.edu	37	1	2160775	2160775	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:2160775C>T	ENST00000378536.4	+	1	642	c.570C>T	c.(568-570)ctC>ctT	p.L190L		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	190					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		ACGCGCTGCTCTACGGCGGCG	0.692000													4	10					0	0	0.000602	0	0
NLRC4	58484	broad.mit.edu	37	2	32476577	32476577	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32476577G>A	ENST00000404025.2	-	5	844	c.356C>T	c.(355-357)cCc>cTc	p.P119L	NLRC4_ENST00000360906.5_Missense_Mutation_p.P119L|NLRC4_ENST00000402280.1_Missense_Mutation_p.P119L|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	119					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCACCAAGGGGATAAAAGTT	0.433000													27	40					0	0	0.004656	0	0
FAM83B	222584	broad.mit.edu	37	6	54792428	54792428	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:54792428C>A	ENST00000306858.7	+	4	848	c.732C>A	c.(730-732)taC>taA	p.Y244*		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	244										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					ACGGTTCTTACAGGTAAGATC	0.299000													44	83					2.74695e-27	2.96131e-27	0.014410	1	0
TRMT13	54482	broad.mit.edu	37	1	100613702	100613702	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:100613702G>T	ENST00000370141.2	+	10	1076	c.1070G>T	c.(1069-1071)gGa>gTa	p.G357V		NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		CTAGGCCTTGGAGCAGTGGAA	0.458000													19	39					1.96292e-10	2.06245e-10	0.010504	1	0
SULF1	23213	broad.mit.edu	37	8	70539481	70539481	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:70539481G>C	ENST00000260128.4	+	16	2604	c.1887G>C	c.(1885-1887)gaG>gaC	p.E629D	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000419716.3_Missense_Mutation_p.E629D|SULF1_ENST00000458141.2_Missense_Mutation_p.E629D|SULF1_ENST00000402687.4_Missense_Mutation_p.E629D	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	629					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TCCATTGTGAGAGAGAACTGT	0.388000													8	64					0	0	0.006214	0	0
SOGA1	140710	broad.mit.edu	37	20	35444081	35444081	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35444081C>T	ENST00000237536.4	-	5	2105	c.1764G>A	c.(1762-1764)aaG>aaA	p.K588K	SOGA1_ENST00000357779.3_Silent_p.K350K|SOGA1_ENST00000279034.5_Silent_p.K350K|SOGA1_ENST00000456801.2_Silent_p.K191K	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	350										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						ACTGCAGCTTCTTGACCTTGC	0.647000													6	9					0	0	0.001168	0	0
PROK1	84432	broad.mit.edu	37	1	110998955	110998955	+	Missense_Mutation	SNP	G	G	C	rs148436202		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:110998955G>C	ENST00000271331.3	+	3	317	c.300G>C	c.(298-300)ttG>ttC	p.L100F		NM_032414.2	NP_115790.1	P58294	PROK1_HUMAN	prokineticin 1	100					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCATGGACTTGAAGAACATCA	0.537000													9	94					0	0	0.004482	0	0
ARMC4	55130	broad.mit.edu	37	10	28151529	28151529	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:28151529G>T	ENST00000305242.5	-	18	2725	c.2633C>A	c.(2632-2634)tCc>tAc	p.S878Y	ARMC4_ENST00000545014.1_Missense_Mutation_p.S403Y|ARMC4_ENST00000537576.1_Missense_Mutation_p.S570Y	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	878							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ACCAACAAAGGAACGAACCAT	0.348000													15	17					4.7546e-09	4.9263e-09	0.004007	1	0
TRBV7-7	28591	broad.mit.edu	37	7	142120047	142120047	+	RNA	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:142120047G>C	ENST00000390377.1	-	0	119																											GATCACACCTGAGAGTTACAT	0.478000													21	40					0	0	0.012319	0	0
WDR81	124997	broad.mit.edu	37	17	1636020	1636020	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:1636020G>A	ENST00000409644.1	+	6	4384	c.4384G>A	c.(4384-4386)Gat>Aat	p.D1462N	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Missense_Mutation_p.D101N|WDR81_ENST00000437219.2_Missense_Mutation_p.D259N|WDR81_ENST00000419248.1_Missense_Mutation_p.D235N|WDR81_ENST00000309182.5_Missense_Mutation_p.D411N|WDR81_ENST00000545662.1_Missense_Mutation_p.D93N	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	235										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGTCTTCTCTGATGGGCAGCA	0.642000													14	26					0	0	0.003163	0	0
CD101	9398	broad.mit.edu	37	1	117554213	117554213	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:117554213C>G	ENST00000256652.4	+	3	524	c.466C>G	c.(466-468)Ctc>Gtc	p.L156V	CD101_ENST00000369470.1_Missense_Mutation_p.L156V	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	156	Ig-like C2-type 2.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTCTCAGACTCTCGGTAAGGA	0.512000													39	73					0	0	0.008740	0	0
CNGB3	54714	broad.mit.edu	37	8	87645092	87645092	+	Missense_Mutation	SNP	C	C	T	rs147876778	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:87645092C>T	ENST00000320005.5	-	11	1255	c.1208G>A	c.(1207-1209)cGa>cAa	p.R403Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	403			R -> Q (in macular degeneration).		signal transduction|visual perception	integral to membrane	cGMP binding	p.R403P(1)|p.R403L(1)		NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AATTAAAGTTCGAACTGCCCA	0.328000													18	42					0	0	0.007413	0	0
KRT27	342574	broad.mit.edu	37	17	38935781	38935781	+	Silent	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:38935781C>T	ENST00000301656.3	-	5	985	c.945G>A	c.(943-945)gaG>gaA	p.E315E		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	315	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				GAAGTTCAATCTCAAGGGTTT	0.453000													25	255					0	0	0.008361	0	0
KCNC2	3747	broad.mit.edu	37	12	75601539	75601539	+	Silent	SNP	G	G	A			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:75601539G>A	ENST00000549446.1	-	2	905	c.225C>T	c.(223-225)ggC>ggT	p.G75G	KCNC2_ENST00000393288.2_Silent_p.G75G|KCNC2_ENST00000540018.1_Silent_p.G75G|KCNC2_ENST00000341669.3_Silent_p.G75G|KCNC2_ENST00000298972.1_Silent_p.G75G|KCNC2_ENST00000350228.2_Silent_p.G75G|KCNC2_ENST00000550433.1_Silent_p.G75G|KCNC2_ENST00000548513.1_Silent_p.G75G	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	75	Gly/Pro-rich (insert).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CGAAGCAGCCGCCTGGCCCGg	0.766000													7	1					0	0	0.003080	0	0
APBB1	322	broad.mit.edu	37	11	6422239	6422239	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:6422239A>G	ENST00000389906.2	-	11	1751	c.1652T>C	c.(1651-1653)gTa>gCa	p.V551A	APBB1_ENST00000524626.1_5'UTR|APBB1_ENST00000299402.6_Missense_Mutation_p.V549A|APBB1_ENST00000311051.3_Missense_Mutation_p.V549A|APBB1_ENST00000530885.1_Missense_Mutation_p.V329A	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	551	PID 2.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AGCAACAGGTACATTCCCCAG	0.478000													9	216					0	0	0.008291	0	0
ABCB11	8647	broad.mit.edu	37	2	169792772	169792772	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:169792772G>C	ENST00000263817.6	-	22	2906	c.2782C>G	c.(2782-2784)Cga>Gga	p.R928G		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	928	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TGCTTATCTCGAGAGGCAAAT	0.488000													18	29					0	0	0.006122	0	0
ABCA7	10347	broad.mit.edu	37	19	1055346	1055346	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:1055346C>T	ENST00000263094.6	+	30	4432	c.4201C>T	c.(4201-4203)Cag>Tag	p.Q1401*	ABCA7_ENST00000435683.2_Nonsense_Mutation_p.Q1263*|ABCA7_ENST00000433129.1_Nonsense_Mutation_p.Q1401*	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1401					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGTGCGCCAGGGGTGAGC	0.637000													5	18					0	0	0.001168	0	0
FBXO4	26272	broad.mit.edu	37	5	41934106	41934106	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:41934106C>G	ENST00000296812.2	+	4	761	c.705C>G	c.(703-705)atC>atG	p.I235M	FBXO4_ENST00000509134.1_Missense_Mutation_p.I235M|FBXO4_ENST00000281623.3_Missense_Mutation_p.I235M	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	235					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				ACATTCTAATCTTATATTCAA	0.328000													16	69					0	0	0.004990	0	0
FAM83A	84985	broad.mit.edu	37	8	124219708	124219708	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:124219708A>C	ENST00000518448.1	+	5	3099	c.1085A>C	c.(1084-1086)cAc>cCc	p.H362P	FAM83A_ENST00000522648.1_Intron|FAM83A_ENST00000276699.6_Intron|FAM83A_ENST00000546351.1_Intron|FAM83A_ENST00000536633.1_Intron|FAM83A_ENST00000318462.6_Missense_Mutation_p.H362P			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	362	Pro-rich.									breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGGCCCCACACCCGCCTCCA	0.766000													5	13					0	0	0.004482	0	0
DUS2	54920	broad.mit.edu	37	16	68109341	68109341	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68109341C>T	ENST00000565263.1	+	14	1510	c.1016C>T	c.(1015-1017)tCa>tTa	p.S339L	DUS2L_ENST00000432752.1_Missense_Mutation_p.S304L|DUS2L_ENST00000358896.6_Missense_Mutation_p.S339L	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN		339					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		GCCAAGACTTCAGAGCAGACA	0.567000													20	32					0	0	0.012319	0	0
FLG2	388698	broad.mit.edu	37	1	152327320	152327320	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:152327320G>C	ENST00000388718.5	-	3	3014	c.2942C>G	c.(2941-2943)tCa>tGa	p.S981*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	981	Ser-rich.						calcium ion binding|structural molecule activity	p.S981*(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATTTTCCTGAGCCTGACTC	0.493000													12	592					0	0	0.010729	0	0
HACE1	57531	broad.mit.edu	37	6	105281023	105281023	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:105281023C>T	ENST00000262903.4	-	6	704	c.428G>A	c.(427-429)cGg>cAg	p.R143Q	HACE1_ENST00000369125.2_Missense_Mutation_p.R143Q|RP11-809N15.2_ENST00000422930.1_RNA	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	143					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TAGTTCTGTCCGCCCATTCAC	0.423000													25	75					0	0	0.006320	0	0
INPP5B	3633	broad.mit.edu	37	1	38339682	38339682	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:38339682C>T	ENST00000373023.2	-	18	2267	c.2174G>A	c.(2173-2175)aGa>aAa	p.R725K	INPP5B_ENST00000373024.3_Missense_Mutation_p.R645K|INPP5B_ENST00000373026.1_Missense_Mutation_p.R725K|INPP5B_ENST00000458109.2_3'UTR|INPP5B_ENST00000373027.1_Missense_Mutation_p.R481K	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	725					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GAGGAAGCCTCTGCTGGGGTT	0.438000													18	18					0	0	0.008871	0	0
SLC39A14	23516	broad.mit.edu	37	8	22262337	22262337	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:22262337C>G	ENST00000359741.5	+	2	289	c.114C>G	c.(112-114)atC>atG	p.I38M	SLC39A14_ENST00000240095.6_Missense_Mutation_p.I38M|SLC39A14_ENST00000381237.1_Missense_Mutation_p.I38M|SLC39A14_ENST00000289952.5_Missense_Mutation_p.I38M	NM_015359.4	NP_056174.2	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter), member 14	38						endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity			NS(1)|endometrium(4)|large_intestine(2)|lung(4)|prostate(1)	12				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CACCAGCTATCAGCGCTGCCT	0.602000													3	76					0	0	0.009096	0	0
HDGF	3068	broad.mit.edu	37	1	156713644	156713648	+	Frame_Shift_Del	DEL	TGCCT	TGCCT	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:156713644_156713648delTGCCT	ENST00000357325.5	-	5	826_830	c.512_516delAGGCA	c.(511-516)gfs	p.EA171fs	HDGF_ENST00000465180.1_5'UTR|HDGF_ENST00000537739.1_Frame_Shift_Del_p.EA171fs|HDGF_ENST00000416666.2_Frame_Shift_Del_p.EA139fs|HDGF_ENST00000368206.5_Frame_Shift_Del_p.EA187fs|HDGF_ENST00000368209.5_Frame_Shift_Del_p.EA164fs	NM_004494.2	NP_004485.1	P51858	HDGF_HUMAN	hepatoma-derived growth factor	171	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CAGGGTTTTCTGCCTCCTTGGGACG	0.605													20	60	---	---	---	---					
LYST	1130	broad.mit.edu	37	1	235964315	235964327	+	Frame_Shift_Del	DEL	TTCCCCTTGAGTG	TTCCCCTTGAGTG	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:235964315_235964327delTTCCCCTTGAGTG	ENST00000389794.3	-	9	3957_3969	c.3783_3795delCACTCAAGGGGAA	c.(3781-3795)ctfs	p.LTQGE1261fs	LYST_ENST00000389793.2_Frame_Shift_Del_p.LTQGE1261fs|LYST_ENST00000536965.1_Frame_Shift_Del_p.LTQGE1261fs			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1261					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GATAAATTATTTCCCCTTGAGTGAGGTTTTCGA	0.366													20	139	---	---	---	---					
CD8B	926	broad.mit.edu	37	2	87085532	87085533	+	Frame_Shift_Ins	INS	-	-	T	rs137953763	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:87085532_87085533insT	ENST00000390655.6	-	2	108_109	c.50_51insA	c.(49-51)cggfs	p.R17fs	CD8B_ENST00000349455.3_Frame_Shift_Ins_p.R17fs|CD8B_ENST00000431506.2_Intron|CD8B_ENST00000331469.2_Frame_Shift_Ins_p.R17fs|CD8B_ENST00000393759.2_Frame_Shift_Ins_p.R17fs|CD8B_ENST00000393761.2_Frame_Shift_Ins_p.R17fs	NM_004931.4	NP_004922.1	P10966	CD8B_HUMAN	CD8b molecule	17					immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						CTGAGTTGCCATGGAGAACTAG	0.490													22	39	---	---	---	---					
RNPEPL1	57140	broad.mit.edu	37	2	241517130	241517131	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:241517130_241517131delAG	ENST00000270357.3	+	11	1899_1900	c.1306_1307delAG	c.(1306-1308)afs	p.R436fs		NM_018226.4	NP_060696.4	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like 1	436					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	13		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CAACCTGCGCAGAGCCATCCAG	0.663													7	7	---	---	---	---					
IQUB	154865	broad.mit.edu	37	7	123109372	123109372	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:123109372delT	ENST00000466202.1	-	9	2053	c.1477delA	c.(1477-1479)tcfs	p.I493fs	IQUB_ENST00000434450.1_Frame_Shift_Del_p.I493fs|IQUB_ENST00000324698.6_Frame_Shift_Del_p.I493fs			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	493										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						CTGGCTCTGATGGTGAACTGC	0.358													31	134	---	---	---	---					
TOX	9760	broad.mit.edu	37	8	59750796	59750798	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:59750796_59750798delCTT	ENST00000361421.1	-	5	986_988	c.766_768delAAG	c.(766-768)del	p.K256del		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	256						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CATTGGGATCCTTCTTCTTCTTC	0.453													8	420	---	---	---	---					
MYBL1	4603	broad.mit.edu	37	8	67488453	67488453	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:67488453delT	ENST00000522677.3	-	10	1669	c.1259delA	c.(1258-1260)acfs	p.N420fs	MYBL1_ENST00000517885.1_Intron|MYBL1_ENST00000524176.2_Frame_Shift_Del_p.N420fs	NM_001080416.2|NM_001144755.1	NP_001073885.1|NP_001138227.1	P10243	MYBA_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 1	420	Negative regulatory domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|skin(1)	25			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATTACAAGTGTTTTTTTTCCC	0.403													7	442	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:98336475delT	ENST00000371142.4	-	2	430	c.214delA	c.(214-216)gtfs	p.S72fs		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	72						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363													7	163	---	---	---	---					
PDE3A	5139	broad.mit.edu	37	12	20782960	20782977	+	In_Frame_Del	DEL	AACTGCCAAACAAAGCCT	AACTGCCAAACAAAGCCT	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:20782960_20782977delAACTGCCAAACAAAGCCT	ENST00000359062.3	+	6	1699_1716	c.1659_1676delAACTGCCAAACAAAGCCT	c.(1657-1677)aca>ac	p.TTAKQSL553del	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	553					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCAC	0.500													9	144	---	---	---	---					
WHAMMP3	339005	broad.mit.edu	37	15	23205231	23205231	+	RNA	DEL	G	G	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:23205231delG	ENST00000400153.2	-	0	656					NR_003521.1																						GCTCAAGTCAGGACAGTGTAA	0.333													4	5	---	---	---	---					
MYH10	4628	broad.mit.edu	37	17	8415820	8415822	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:8415820_8415822delTTC	ENST00000360416.3	-	24	3037_3039	c.2899_2901delGAA	c.(2899-2901)del	p.E967del	MYH10_ENST00000269243.4_In_Frame_Del_p.E936del|MYH10_ENST00000379980.4_In_Frame_Del_p.E952del|MYH10_ENST00000396239.1_In_Frame_Del_p.E957del	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	936					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTTGGTTTCTTTCTTCTTCTTCT	0.350													7	100	---	---	---	---					
AKAP1	8165	broad.mit.edu	37	17	55183460	55183460	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:55183460delA	ENST00000337714.3	+	2	868	c.635delA	c.(634-636)gafs	p.E212fs	AKAP1_ENST00000571629.1_Frame_Shift_Del_p.E212fs|AKAP1_ENST00000539273.1_Frame_Shift_Del_p.E212fs|AKAP1_ENST00000572557.1_Frame_Shift_Del_p.E212fs|AKAP1_ENST00000314126.3_Frame_Shift_Del_p.E212fs	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	212					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					GTGTTGGGGGAAAAGGTGCTT	0.587													7	432	---	---	---	---					
GLTSCR2	29997	broad.mit.edu	37	19	48258620	48258620	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:48258620delG	ENST00000246802.5	+	9	1107	c.1069delG	c.(1069-1071)cgfs	p.A357fs	GLTSCR2_ENST00000598681.1_3'UTR	NM_015710.4	NP_056525.2	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	357						nucleolus				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	15		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		ACAGCAGGCCGCGTTGCGGGC	0.721													2	4	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50156573	50156573	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:50156573delC	ENST00000360565.3	+	7	3051	c.2927delC	c.(2926-2928)acfs	p.T976fs		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	976					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GTTCCTAGCACCCCGCCCCCC	0.682													2	4	---	---	---	---					
DLGAP4	22839	broad.mit.edu	37	20	35155318	35155330	+	Frame_Shift_Del	DEL	GAGGCCCGCAAGA	GAGGCCCGCAAGA	-			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35155318_35155330delGAGGCCCGCAAGA	ENST00000373913.3	+	13	3334_3346	c.2854_2866delGAGGCCCGCAAGA	c.(2854-2868)gafs	p.EARKR952fs	DLGAP4_ENST00000339266.5_Frame_Shift_Del_p.EARKR955fs|DLGAP4_ENST00000340491.4_Frame_Shift_Del_p.EARKR416fs|DLGAP4_ENST00000401952.2_Frame_Shift_Del_p.EARKR952fs|RP5-977B1.7_ENST00000425233.1_RNA|DLGAP4_ENST00000373907.2_Frame_Shift_Del_p.EARKR955fs|DLGAP4_ENST00000475894.1_3'UTR|RP5-977B1.7_ENST00000439595.1_RNA			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	955					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GCAGCGCCAGGAGGCCCGCAAGAGACTCCTGGC	0.638													23	45	---	---	---	---					
ATXN3L	92552	broad.mit.edu	37	X	13337468	13337469	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:13337468_13337469insT	ENST00000380622.2	-	1	1049_1050	c.585_586insA	c.(583-588)aatagtfs	p.NS195fs	GS1-600G8.3_ENST00000431486.1_RNA	NM_001135995.1	NP_001129467.1	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	195					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TGTTTTACTAATTTTTTTCCAT	0.381													158	70	---	---	---	---					
