Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SOX5	6660	broad.mit.edu	37	12	23696176	23696176	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr12:23696176G>A	ENST00000546136.1	-	12	1703	c.1701C>T	c.(1699-1701)gaC>gaT	p.D567D	SOX5_ENST00000545921.1_Silent_p.D570D|SOX5_ENST00000451604.2_Silent_p.D580D|SOX5_ENST00000381381.2_Silent_p.D459D|SOX5_ENST00000396007.2_Silent_p.D194D|SOX5_ENST00000309359.1_Silent_p.D567D|SOX5_ENST00000541536.1_Silent_p.D459D|SOX5_ENST00000537393.1_Silent_p.D545D			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	580					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AGTTGTGCATGTCAGGAAAGG	0.438000													18	100					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72948430	72948430	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr17:72948430G>A	ENST00000425042.2	-	17	2155	c.2078C>T	c.(2077-2079)cCg>cTg	p.P693L		NM_030630.2	NP_085133.1			HID1 domain containing																		GGTCTGCAGCGGCAGCTTCGA	0.667000													7	59					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101892219	101892219	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:101892219G>A	ENST00000360264.3	+	24	4468	c.4448G>A	c.(4447-4449)cGc>cAc	p.R1483H	CUX1_ENST00000550008.2_Missense_Mutation_p.R1416H|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292535.7_Missense_Mutation_p.R1472H|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Missense_Mutation_p.R1314H|CUX1_ENST00000549414.2_Missense_Mutation_p.R1450H|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Missense_Mutation_p.R1370H|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1472					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CGGGACTCGCGCGACAACCCC	0.697000													3	17					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													8	140					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106054585	106054585	+	RNA	SNP	C	C	A	rs113035575		TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr14:106054585C>A	ENST00000390539.2	-	0	147																											AAGTTTCTGGCGGTCACGTTC	0.642000													10	61					2.74318e-10	3.16119e-10	1	1	0
MROH6	642475	broad.mit.edu	37	8	144650361	144650361	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:144650361A>G	ENST00000398882.3	-	11	1971	c.1715T>C	c.(1714-1716)gTg>gCg	p.V572A	MROH6_ENST00000534459.1_5'UTR|MROH6_ENST00000533679.1_Intron|MROH6_ENST00000524906.1_5'UTR	NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		ATAGTGGGCCACGGTGACCAA	0.652000													6	26					0	0	1	0	0
TMEM244	253582	broad.mit.edu	37	6	130166922	130166922	+	Missense_Mutation	SNP	C	C	T	rs143949103	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr6:130166922C>T	ENST00000438392.1	-	3	289	c.109G>A	c.(109-111)Gtg>Atg	p.V37M	TMEM244_ENST00000368143.1_Missense_Mutation_p.V37M			Q5VVB8	CF191_HUMAN	transmembrane protein 244	37						integral to membrane		p.V37M(1)									TCAAACATCACGCAGCCCATG	0.358000													12	91					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562959	178562959	+	Missense_Mutation	SNP	C	C	T	rs144554943		TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr5:178562959C>T	ENST00000251582.7	-	13	2137	c.2036G>A	c.(2035-2037)cGc>cAc	p.R679H		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	679	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTAGGAGCAGCGCGTCCCGTC	0.637000													16	111					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160607290	160607290	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:160607290G>T	ENST00000302035.6	-	2	455	c.106C>A	c.(106-108)Ctc>Atc	p.L36I	SLAMF1_ENST00000538290.1_Missense_Mutation_p.L36I|SLAMF1_ENST00000355199.3_Missense_Mutation_p.L36I|SLAMF1_ENST00000235739.5_Missense_Mutation_p.L36I|SLAMF1_ENST00000494463.1_5'UTR	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	36					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AACTGCCGGAGAATCTTTGGG	0.473000													4	36					0.150653	0.151909	1	1	0
MIR182	406958	broad.mit.edu	37	7	129410237	129410237	+	RNA	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:129410237C>T	ENST00000385255.1	-	0	95					NR_029614.1																						CGGCTGAGTCCTCGCCCCATA	0.632000													3	40					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071698	134071698	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr4:134071698G>A	ENST00000264360.4	+	1	1229	c.403G>A	c.(403-405)Gcc>Acc	p.A135T		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	135	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTCTGAGAGCGCCACGCCAGG	0.607000													30	134					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33068512	33068512	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr21:33068512G>A	ENST00000286835.7	-	9	1364	c.982C>T	c.(982-984)Cag>Tag	p.Q328*	SCAF4_ENST00000399804.1_Nonsense_Mutation_p.Q328*|SCAF4_ENST00000434667.3_Nonsense_Mutation_p.Q313*	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	328						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GCTGGCTGCTGCATGCCATCT	0.418000													39	187					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133196535	133196535	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:133196535C>A	ENST00000388996.4	-	3	977	c.557G>T	c.(556-558)gGc>gTc	p.G186V	KCNQ3_ENST00000519445.1_Missense_Mutation_p.G186V|KCNQ3_ENST00000521134.1_Missense_Mutation_p.G66V	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	186					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCCCCGCCAGCCTTTGTATCG	0.542000													30	187					2.08457e-15	2.42531e-15	1	1	0
MROH7	374977	broad.mit.edu	37	1	55175809	55175809	+	Silent	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:55175809C>T	ENST00000421030.2	+	24	4206	c.3921C>T	c.(3919-3921)cgC>cgT	p.R1307R	MROH7_ENST00000409996.1_Silent_p.R875R|MROH7_ENST00000414150.2_Intron|MROH7_ENST00000454855.2_Silent_p.R825R	NM_001039464.2	NP_001034553.2			maestro heat-like repeat family member 7																		ACCAGCGGCGCTCCTGGATCA	0.622000													5	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179528398	179528398	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:179528398G>A	ENST00000589042.1	-	171	36712	c.36488C>T	c.(36487-36489)gCg>gTg	p.A12163V	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10312	Ig-like 81.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCACTGGCGCTTTCTTTTC	0.388000													35	244					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													4	29					0	0	1	0	0
MB21D1	115004	broad.mit.edu	37	6	74135219	74135219	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr6:74135219A>G	ENST00000370315.3	-	5	1394	c.1300T>C	c.(1300-1302)Tct>Cct	p.S434P	MB21D1_ENST00000370318.1_Missense_Mutation_p.S434P	NM_138441.2	NP_612450.2	Q8N884	M21D1_HUMAN	Mab-21 domain containing 1	434										central_nervous_system(1)|large_intestine(4)|lung(1)	6						TGATAAGAAGAGAATTTATCC	0.373000													7	26					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138806	126138806	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr12:126138806A>T	ENST00000299308.3	+	9	2795	c.2787A>T	c.(2785-2787)aaA>aaT	p.K929N	TMEM132B_ENST00000535886.1_Missense_Mutation_p.K441N	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	929						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACAGACACAAAAGGTTTGCTG	0.502000													9	103					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3295768	3295768	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr20:3295768C>T	ENST00000252032.9	-	20	1658		c.e20-1		C20orf194_ENST00000453730.2_Splice_Site|C20orf194_ENST00000498079.1_Splice_Site	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194											NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						ACTCATCCCCCTTTAAAAACA	0.388000													16	76					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34546573	34546573	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr15:34546573G>A	ENST00000354181.3	-	9	1586	c.1094C>T	c.(1093-1095)tCt>tTt	p.S365F	SLC12A6_ENST00000558589.1_Missense_Mutation_p.S356F|SLC12A6_ENST00000558667.1_Missense_Mutation_p.S365F|SLC12A6_ENST00000451844.2_Missense_Mutation_p.S177F|SLC12A6_ENST00000560164.1_Missense_Mutation_p.S177F|SLC12A6_ENST00000458406.2_Missense_Mutation_p.S306F|SLC12A6_ENST00000397702.2_Missense_Mutation_p.S306F|SLC12A6_ENST00000397707.2_Missense_Mutation_p.S350F|SLC12A6_ENST00000560611.1_Missense_Mutation_p.S365F|SLC12A6_ENST00000290209.5_Missense_Mutation_p.S314F			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	365					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AGCAAAAGAAGACTTGATGGC	0.453000													4	145					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111146157	111146157	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:111146157G>A	ENST00000485317.1	-	3	1921	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	KCNA2_ENST00000369770.3_Intron|KCNA2_ENST00000440270.1_Silent_p.F416F|KCNA2_ENST00000316361.4_Silent_p.F416F			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	416						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CCCGGTGGTAGAAGTAGTTGA	0.488000													18	91					0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr9:35906559A>C	ENST00000354323.2	+	1	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane		p.H92P(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000													3	11					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328944	88328944	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr13:88328944G>A	ENST00000325089.6	+	2	1520	c.1301G>A	c.(1300-1302)gGg>gAg	p.G434E	SLITRK5_ENST00000400028.3_Missense_Mutation_p.G193E	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	434						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GAGGCCACGGGGCTGGACCTC	0.572000													6	72					0	0	1	0	0
PTP4A2	8073	broad.mit.edu	37	1	32377362	32377362	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:32377362T>A	ENST00000344035.6	-	4	1248	c.255A>T	c.(253-255)ttA>ttT	p.L85F	PTP4A2_ENST00000602725.1_Missense_Mutation_p.L85F|PTP4A2_ENST00000470404.1_Intron|PTP4A2_ENST00000457805.2_Missense_Mutation_p.L54F|PTP4A2_ENST00000356536.3_Intron|RP11-84A19.4_ENST00000602889.1_lincRNA	NM_080391.3	NP_536316.1	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	85	Tyrosine-protein phosphatase.					early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity			kidney(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				ATTTGGTTTTTAACAGGTTTA	0.383000													14	73					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170489726	170489726	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:170489726C>A	ENST00000260970.3	+	12	1206	c.986C>A	c.(985-987)tCt>tAt	p.S329Y	PPIG_ENST00000448752.2_Missense_Mutation_p.S329Y|PPIG_ENST00000482772.1_3'UTR|PPIG_ENST00000409714.3_Missense_Mutation_p.S314Y|PPIG_ENST00000462903.1_Missense_Mutation_p.S329Y	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	329					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	GTTACTAGATCTGGCAGGAAA	0.373000													10	37					1.58986e-06	1.76489e-06	1	1	0
MUC17	140453	broad.mit.edu	37	7	100676343	100676343	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:100676343G>A	ENST00000306151.4	+	3	1710	c.1646G>A	c.(1645-1647)aGt>aAt	p.S549N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	549	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTGAAGCCAGTTCATCTTCT	0.512000													205	530					0	0	1	0	0
LZTS1	11178	broad.mit.edu	37	8	20107511	20107511	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:20107511C>T	ENST00000381569.1	-	4	1870	c.1513G>A	c.(1513-1515)Gag>Aag	p.E505K	LZTS1_ENST00000265801.6_Missense_Mutation_p.E505K|LZTS1_ENST00000522290.1_Intron			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	505					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		CGCAGCCGCTCCAGCTCCCGC	0.716000													12	97					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30727716	30727716	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr16:30727716G>A	ENST00000262518.4	+	18	3118	c.2733G>A	c.(2731-2733)ccG>ccA	p.P911P	SRCAP_ENST00000344771.4_Silent_p.P911P|SRCAP_ENST00000395059.2_Silent_p.P911P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	911					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ACCCTCGACCGGTTACCTCCC	0.512000													6	545					0	0	1	0	0
LRRC17	10234	broad.mit.edu	37	7	102580025	102580025	+	Silent	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:102580025C>T	ENST00000249377.4	+	3	1202	c.921C>T	c.(919-921)atC>atT	p.I307I	FBXL13_ENST00000313221.4_Intron|LRRC17_ENST00000485478.1_3'UTR|LRRC17_ENST00000339431.4_Silent_p.I307I|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000379308.3_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	307					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						TTGAATTCATCGATCCTGGTA	0.373000													14	104					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67709344	67709344	+	Missense_Mutation	SNP	C	C	T	rs142100170	byFrequency	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr15:67709344C>T	ENST00000335894.4	+	15	2239	c.2173C>T	c.(2173-2175)Cgg>Tgg	p.R725W	IQCH_ENST00000358767.3_Missense_Mutation_p.R461W|IQCH_ENST00000360277.4_Missense_Mutation_p.R386W|IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000546225.1_Missense_Mutation_p.R382W	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	725										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CAATGAGAAACGGTTCCCGAC	0.443000													13	45					0	0	1	0	0
AKR7A3	22977	broad.mit.edu	37	1	19612764	19612764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:19612764C>T	ENST00000361640.4	-	2	857	c.317G>A	c.(316-318)cGa>cAa	p.R106Q		NM_012067.2	NP_036199.2	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	106					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity	p.R106Q(1)		NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)	13		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGTCCACTCGGGGACACTG	0.592000													26	129					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108620880	108620880	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr12:108620880G>A	ENST00000332082.4	+	7	1736	c.918G>A	c.(916-918)gcG>gcA	p.A306A	WSCD2_ENST00000547525.1_Silent_p.A306A|WSCD2_ENST00000549903.1_Silent_p.A306A|WSCD2_ENST00000261400.3_Silent_p.A306A			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	306	WSC 2.					integral to membrane		p.A306A(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						AGTGCAGCGCGGAGGAGTTTG	0.592000													20	99					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1843078	1843078	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:1843078C>T	ENST00000399161.2	-	21	3670	c.2923G>A	c.(2923-2925)Gcc>Acc	p.A975T	MYT1L_ENST00000407844.1_5'UTR|MYT1L_ENST00000471668.1_5'UTR|MYT1L_ENST00000428368.2_Missense_Mutation_p.A973T	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	975					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CACCCGGAGGCGCTGCGATGG	0.632000													17	98					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44778750	44778750	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:44778750A>C	ENST00000391958.2	+	5	2064	c.1937A>C	c.(1936-1938)aAa>aCa	p.K646T	ZNF233_ENST00000592581.1_3'UTR|ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000334152.1_Missense_Mutation_p.K628T	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				ACTGGAGAGAAACCATACAAA	0.418000													45	61					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716227	13716227	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr12:13716227G>A	ENST00000279593.3	-	13	4154	c.3945C>T	c.(3943-3945)gcC>gcT	p.A1315A		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1315					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGCCAGGGCGGCTTCTTCCT	0.597000													23	117					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85345396	85345396	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr15:85345396G>A	ENST00000299927.3	+	8	3598	c.3576G>A	c.(3574-3576)gcG>gcA	p.A1192A	ZNF592_ENST00000560079.2_Silent_p.A1192A			Q92610	ZN592_HUMAN	zinc finger protein 592	1192					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CGGCGGCAGCGGAGATGGCAG	0.617000													7	25					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	79971609	79971609	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:79971609G>A	ENST00000466387.1	+	7	923	c.199G>A	c.(199-201)Gcc>Acc	p.A67T	CTNNA2_ENST00000402739.4_Missense_Mutation_p.A67T|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A67T|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A67T|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A67T|CTNNA2_ENST00000361291.4_Missense_Mutation_p.A101T			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	67					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGTAGAGCAAGCCACTCAGAA	0.468000													5	49					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169315637	169315637	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr4:169315637G>A	ENST00000511577.1	-	28	4036	c.3789C>T	c.(3787-3789)ctC>ctT	p.L1263L	DDX60L_ENST00000505890.1_Silent_p.L1264L|DDX60L_ENST00000260184.7_Silent_p.L1263L			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1263	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTTTTACAAAGAGTATCTCAA	0.323000													4	28					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411686	51411686	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:51411686C>A	ENST00000319760.6	-	1	762	c.710G>T	c.(709-711)tGc>tTc	p.C237F		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				GCCGGAGCTGCAGGTAGACAA	0.408000													12	70					6.40141e-05	6.79448e-05	1	1	0
HERC2P9	440248	broad.mit.edu	37	15	28900606	28900606	+	RNA	SNP	C	C	T	rs150642820	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr15:28900606C>T	ENST00000528584.1	+	0	162					NR_036443.1																						TGGTGAAGAGCGGTGCAGCAG	0.612000													5	24					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27777869	27777869	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr6:27777869G>T	ENST00000369163.2	+	1	28	c.18G>T	c.(16-18)caG>caT	p.Q6H		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	6					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						GTACGAAGCAGACTGCTCGCA	0.582000													13	106					9.31168e-06	1.01506e-05	1	1	0
ACSL6	23305	broad.mit.edu	37	5	131329909	131329909	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr5:131329909G>A	ENST00000379264.2	-	2	193	c.85C>T	c.(85-87)Cag>Tag	p.Q29*	ACSL6_ENST00000379249.3_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000477640.1_5'UTR|ACSL6_ENST00000379244.1_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000379246.1_Nonsense_Mutation_p.Q15*|ACSL6_ENST00000431707.1_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000379272.2_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000544770.1_5'UTR|ACSL6_ENST00000379240.1_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000296869.4_Nonsense_Mutation_p.Q29*|ACSL6_ENST00000543479.1_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000379255.1_Nonsense_Mutation_p.Q4*|ACSL6_ENST00000357096.1_Nonsense_Mutation_p.Q4*	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	4					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGATCTCCTGTGTCTGCATC	0.557000													6	23					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41483450	41483450	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:41483450G>A	ENST00000359345.1	-	2	3390	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C	SLFNL1_ENST00000439569.2_Missense_Mutation_p.R272C|SLFNL1_ENST00000372613.2_Missense_Mutation_p.R272C|SLFNL1_ENST00000372611.1_Missense_Mutation_p.R213C|SLFNL1_ENST00000302946.8_Missense_Mutation_p.R272C|SLFNL1_ENST00000397197.2_Missense_Mutation_p.R272C	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	272							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				TGGCTGCAGCGGATGCCCTGC	0.647000													14	100					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3599708	3599708	+	Silent	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:3599708C>T	ENST00000378295.4	+	3	305	c.150C>T	c.(148-150)gaC>gaT	p.D50D	TP73_ENST00000346387.4_Silent_p.D50D|TP73_ENST00000604074.1_Silent_p.D50D|TP73_ENST00000357733.3_Silent_p.D50D|TP73_ENST00000354437.4_Silent_p.D50D|TP73_ENST00000603362.1_Silent_p.D50D|TP73_ENST00000604479.1_Silent_p.D50D	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	50	Asp/Glu-rich (acidic).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CCAGCATGGACGTCTTCCACC	0.602000													22	130					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149459795	149459795	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr5:149459795C>T	ENST00000286301.3	-	4	703	c.412G>A	c.(412-414)Gtc>Atc	p.V138I	CSF1R_ENST00000543093.1_Missense_Mutation_p.V138I	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	138	Ig-like C2-type 2.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ACCAGCGAGACGCCTGCTTCC	0.637000													10	61					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33065709	33065709	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr21:33065709G>A	ENST00000286835.7	-	12	1793	c.1411C>T	c.(1411-1413)Cga>Tga	p.R471*	SCAF4_ENST00000399804.1_Nonsense_Mutation_p.R471*|SCAF4_ENST00000434667.3_Nonsense_Mutation_p.R456*	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	471						nucleus	nucleotide binding|RNA binding	p.R471*(1)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GGAGAATGTCGGCGTCTATCC	0.498000													10	56					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278661	50278661	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr18:50278661C>T	ENST00000442544.2	+	2	945	c.329C>T	c.(328-330)cCa>cTa	p.P110L	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	110	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACCACAAGCCAGATGAGGGA	0.448000													13	102					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811363	23811363	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr15:23811363C>T	ENST00000314520.3	+	1	910	c.434C>T	c.(433-435)aCg>aTg	p.T145M	MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000564592.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	145			T -> M (in a colorectal cancer sample; somatic mutation).			ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding	p.T145M(1)		breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGCCCTAGCACGGCTGCGCAC	0.652000													7	68					0	0	1	0	0
GRAMD3	65983	broad.mit.edu	37	5	125813462	125813462	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr5:125813462G>T	ENST00000285689.3	+	6	1026	c.565G>T	c.(565-567)Gca>Tca	p.A189S	GRAMD3_ENST00000511134.1_Missense_Mutation_p.A173S|GRAMD3_ENST00000513040.1_Missense_Mutation_p.A204S|RP11-517I3.1_ENST00000515808.1_RNA|GRAMD3_ENST00000543198.1_Missense_Mutation_p.A166S|GRAMD3_ENST00000544396.1_Missense_Mutation_p.A85S|GRAMD3_ENST00000542322.1_Missense_Mutation_p.A197S|GRAMD3_ENST00000502348.1_Missense_Mutation_p.A80S|GRAMD3_ENST00000515200.1_Missense_Mutation_p.A166S	NM_023927.2	NP_076416.2	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3	189										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		CCTGATCATAGCAACAGTCAC	0.493000													15	89					9.16793e-09	1.03675e-08	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1269115	1269115	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:1269115G>A	ENST00000447027.1	+	31	11072	c.11014G>A	c.(11014-11016)Ggc>Agc	p.G3672S	MUC5B_ENST00000529681.1_Missense_Mutation_p.G3669S|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3669	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTGCAACTACGGCCACTGCCC	0.592000													32	246					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39245929	39245929	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr4:39245929G>A	ENST00000399820.3	+	22	2637	c.2483G>A	c.(2482-2484)cGt>cAt	p.R828H	WDR19_ENST00000288634.7_Missense_Mutation_p.R668H	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	828					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GGAGACATACGTCGAGGGGTT	0.468000													12	104					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105923623	105923623	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:105923623T>G	ENST00000526793.1	-	3	1952	c.1793A>C	c.(1792-1794)cAg>cCg	p.Q598P	KBTBD3_ENST00000531837.1_Missense_Mutation_p.Q598P|KBTBD3_ENST00000534815.1_Missense_Mutation_p.Q519P	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	594										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TTTATTAAACTGAATCACCTG	0.378000													8	71					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466000	110466000	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:110466000C>T	ENST00000329608.6	+	6	1148	c.757C>T	c.(757-759)Cca>Tca	p.P253S	CSF1_ENST00000420111.2_Intron|CSF1_ENST00000369801.1_Missense_Mutation_p.P253S|CSF1_ENST00000369802.3_Missense_Mutation_p.P253S|CSF1_ENST00000344188.5_Missense_Mutation_p.P253S	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	253					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAAGCAGCGGCCACCCAGGAG	0.652000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	82					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891942	5891942	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr18:5891942C>A	ENST00000581347.1	-	3	766	c.121G>T	c.(121-123)Gtg>Ttg	p.V41L	TMEM200C_ENST00000383490.2_Missense_Mutation_p.V41L|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	41						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						CCTTTCACCACCACCACGTCG	0.602000													8	42					3.09899e-07	3.47201e-07	1	1	0
ZMAT4	79698	broad.mit.edu	37	8	40554763	40554763	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:40554763C>T	ENST00000297737.6	-	4	496		c.e4+1		ZMAT4_ENST00000315769.7_Splice_Site	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4							nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CCTGCACGTACCTGTGGTCTT	0.517000													18	192					0	0	1	0	0
BCAS3	54828	broad.mit.edu	37	17	58967129	58967129	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr17:58967129C>G	ENST00000589222.1	+	10	803	c.735C>G	c.(733-735)aaC>aaG	p.N245K	BCAS3_ENST00000408905.3_Missense_Mutation_p.N245K|BCAS3_ENST00000588462.1_Missense_Mutation_p.N245K|BCAS3_ENST00000588874.1_Missense_Mutation_p.N16K|BCAS3_ENST00000390652.5_Missense_Mutation_p.N245K|BCAS3_ENST00000585744.1_Missense_Mutation_p.N16K|BCAS3_ENST00000407086.3_Missense_Mutation_p.N245K			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3	245						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ATGCAGAAAACAAGGTAAGAC	0.408000													11	54					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605415	179605415	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:179605415T>C	ENST00000589042.1	-	48	12769	c.12545A>G	c.(12544-12546)gAg>gGg	p.E4182G	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E3865G|TTN_ENST00000342175.6_Missense_Mutation_p.E4011G|TTN_ENST00000460472.2_Missense_Mutation_p.E3819G|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E3944G|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3865							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGATTTTCTCGGTATCTGA	0.413000													21	69					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11141427	11141427	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:11141427G>A	ENST00000358026.2	+	25	3688	c.3404G>A	c.(3403-3405)cGg>cAg	p.R1135Q	SMARCA4_ENST00000429416.3_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000590574.1_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000413806.3_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000589677.1_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000450717.3_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000344626.4_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000541122.2_Missense_Mutation_p.R1135Q|SMARCA4_ENST00000444061.3_Missense_Mutation_p.R1135Q	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1135	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCGGAGGACCGGGGCATGCTG	0.632000			"""F, N, Mis"""		NSCLC								8	13					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	622886	622886	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:622886G>A	ENST00000588649.2	-	7	1474	c.1390C>T	c.(1390-1392)Cgg>Tgg	p.R464W		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	464					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGAGAACCGGCCCTCGTAC	0.682000													14	14					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760546	176760546	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:176760546C>T	ENST00000367662.3	+	19	6112	c.4948C>T	c.(4948-4950)Caa>Taa	p.Q1650*		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1650					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGAGAATCTGCAAGGAGAATG	0.423000													5	62					0	0	1	0	0
CUEDC1	404093	broad.mit.edu	37	17	55946537	55946537	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr17:55946537G>A	ENST00000577830.1	-	7	1299	c.886C>T	c.(886-888)Ccc>Tcc	p.P296S	CUEDC1_ENST00000577840.1_Missense_Mutation_p.P159S|CUEDC1_ENST00000578357.1_5'UTR|CUEDC1_ENST00000360238.2_Missense_Mutation_p.P296S|CUEDC1_ENST00000407144.2_Missense_Mutation_p.P296S	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	296										endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						GACACAGCGGGGTTGGCGTCG	0.607000													6	28					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161138364	161138364	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:161138364C>A	ENST00000367999.4	+	6	880	c.614C>A	c.(613-615)gCa>gAa	p.A205E	PPOX_ENST00000535223.1_Intron|PPOX_ENST00000495483.1_3'UTR|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000352210.5_Missense_Mutation_p.A205E	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	205					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CTGCTGGGGGCAGGTGAGGGG	0.502000													11	63					3.07112e-06	3.37823e-06	1	1	0
AJUBA	84962	broad.mit.edu	37	14	23444276	23444276	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr14:23444276C>T	ENST00000262713.2	-	5	1652	c.1277G>A	c.(1276-1278)tGt>tAt	p.C426Y	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000361265.4_Missense_Mutation_p.C426Y|AJUBA_ENST00000397388.3_Missense_Mutation_p.C9Y	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	426	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										GCATCGGAAACAGCCTGGATG	0.517000													13	71					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681455	55681455	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:55681455C>T	ENST00000344514.1	-	1	603	c.604G>A	c.(604-606)Gtc>Atc	p.V202I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AAACCAAAGACGGTGAATAAC	0.388000													8	77					0	0	1	0	0
PPP6R3	55291	broad.mit.edu	37	11	68312482	68312482	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:68312482A>T	ENST00000393799.2	+	4	671	c.404A>T	c.(403-405)aAa>aTa	p.K135I	PPP6R3_ENST00000393800.2_Missense_Mutation_p.K135I|PPP6R3_ENST00000265637.4_Missense_Mutation_p.K135I|PPP6R3_ENST00000527403.2_Missense_Mutation_p.K135I|PPP6R3_ENST00000265636.5_Missense_Mutation_p.K135I|PPP6R3_ENST00000534534.1_Missense_Mutation_p.K44I|PPP6R3_ENST00000524904.1_Missense_Mutation_p.K135I|PPP6R3_ENST00000524845.1_Missense_Mutation_p.K135I|PPP6R3_ENST00000393801.3_Missense_Mutation_p.K135I|PPP6R3_ENST00000529710.1_Missense_Mutation_p.K135I			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	135					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						ATCAGCAGAAAACCAGAACAG	0.388000													5	61					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151800369	151800369	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:151800369G>T	ENST00000415421.1	+	5	947	c.592G>T	c.(592-594)Gaa>Taa	p.E198*	GALNT11_ENST00000422997.2_Intron|GALNT11_ENST00000434507.1_Intron|GALNT11_ENST00000452146.2_Intron|GALNT11_ENST00000320311.2_Intron|GALNT11_ENST00000430044.2_Intron			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	0	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CTTTGGTAAGGAATGCTGCAC	0.498000													5	30					0.217242	0.217242	1	1	0
FAM189A2	9413	broad.mit.edu	37	9	72006659	72006659	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr9:72006659G>A	ENST00000257515.8	+	11	1712	c.1292G>A	c.(1291-1293)cGg>cAg	p.R431Q	FAM189A2_ENST00000303068.7_Missense_Mutation_p.R266Q|FAM189A2_ENST00000377216.3_Missense_Mutation_p.R218Q|FAM189A2_ENST00000455972.1_Missense_Mutation_p.R431Q	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	431						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						AGGAGGCCCCGGCGAGTGGAG	0.667000													8	36					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172835185	172835185	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr3:172835185G>T	ENST00000351008.3	-	2	520	c.337C>A	c.(337-339)Cct>Act	p.P113T		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	113					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GGGATGTGAGGCAGAGGCATG	0.413000													10	69					2.17888e-05	2.35397e-05	1	1	0
FREM1	158326	broad.mit.edu	37	9	14808085	14808085	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr9:14808085C>G	ENST00000380881.4	-	18	3759	c.2944G>C	c.(2944-2946)Gtt>Ctt	p.V982L	FREM1_ENST00000422223.2_Missense_Mutation_p.V981L|FREM1_ENST00000380880.3_Missense_Mutation_p.V981L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	981					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCATCCGAAACCACCAATGTA	0.448000													21	90					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70367763	70367763	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chrX:70367763G>A	ENST00000374051.3	+	2	486	c.164G>A	c.(163-165)cGa>cAa	p.R55Q	NLGN3_ENST00000358741.3_Missense_Mutation_p.R55Q|NLGN3_ENST00000536169.1_Missense_Mutation_p.R55Q	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	55					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					AGGGGTGCCCGAGTACCACTG	0.627000													8	10					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206745	142206745	+	RNA	SNP	T	T	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:142206745T>G	ENST00000426318.2	-	0	160																											CAAGGTCACCTGCCTTCCTGT	0.498000													23	111					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95004436	95004436	+	Splice_Site	SNP	C	C	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr9:95004436C>G	ENST00000375643.3	-	29	3443	c.3177_splice	c.e29+1	p.Q1059_splice	IARS_ENST00000447699.2_Splice_Site_p.Q949_splice|IARS_ENST00000474340.1_5'UTR|IARS_ENST00000375629.3_Splice_Site_p.Q112_splice|IARS_ENST00000375627.1_Splice_Site_p.Q112_splice|IARS_ENST00000443024.2_Splice_Site_p.Q1059_splice	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	1059					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CAGGACTCACCTGTGTTTTTT	0.413000													16	80					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12958063	12958063	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:12958063G>A	ENST00000276297.4	-	9	2192	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C	DLC1_ENST00000520226.1_Missense_Mutation_p.R84C|DLC1_ENST00000358919.2_Missense_Mutation_p.R158C|DLC1_ENST00000512044.2_Missense_Mutation_p.R192C	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	595					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CTGAGGCTGCGGACGGAAGAC	0.701000													17	116					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240003803	240003803	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr2:240003803C>A	ENST00000345617.3	-	21	3423	c.2632G>T	c.(2632-2634)Gat>Tat	p.D878Y	HDAC4_ENST00000543185.1_Missense_Mutation_p.D462Y	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	878	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCTACCTCATCAGGAGCCCCG	0.657000													24	134					4.43304e-23	5.20774e-23	1	1	0
RNF219	79596	broad.mit.edu	37	13	79189852	79189852	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr13:79189852G>C	ENST00000282003.6	-	6	2102	c.2044C>G	c.(2044-2046)Ctt>Gtt	p.L682V	RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000560209.2_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	682	Ser-rich.						zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TGGTTATGAAGACTGTGCATC	0.388000													28	101					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534289	534289	+	Missense_Mutation	SNP	C	C	T	rs104894229		TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:534289C>T	ENST00000417302.1	-	2	221	c.34G>A	c.(34-36)Ggc>Agc	p.G12S	HRAS_ENST00000311189.7_Missense_Mutation_p.G12S|HRAS_ENST00000397596.2_Missense_Mutation_p.G12S|HRAS_ENST00000451590.1_Missense_Mutation_p.G12S|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Missense_Mutation_p.G12S	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	12			G -> A (in FCSS).|G -> C (in FCSS).|G -> E (in FCSS).|G -> S (in FCSS, OSCC and CMEMS).|G -> V (in FCSS, bladder carcinoma and CMEMS; constitutively activated; interacts and recruits PLCE1 to plasma membrane; loss of interaction with and recruitment to plasma membrane of PLCE1 when associated with F-32; loss of interaction with PLCE1 when associated with G-26, F-32 and S-35; no effect on interaction with PLCE1 when associated with A-29, G-34, G-37, N-38 and C-39; no effect on subcellular location of isoform 2).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12S(58)|p.G12C(25)|p.G12R(12)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCCACACCGCCGGCGCCCACC	0.647000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			11	63					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66067341	66067341	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:66067341C>T	ENST00000349533.6	+	9	1446	c.1261C>T	c.(1261-1263)Cgc>Tgc	p.R421C	LEPR_ENST00000371059.3_Missense_Mutation_p.R421C|LEPR_ENST00000371060.3_Missense_Mutation_p.R421C|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000371058.1_Missense_Mutation_p.R421C|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000344610.8_Missense_Mutation_p.R421C	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	421	Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATGCCATCATCGCTATGCTGA	0.358000													5	26					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173952657	173952657	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:173952657C>T	ENST00000367696.2	-	4	842	c.491G>A	c.(490-492)cGa>cAa	p.R164Q	RC3H1_ENST00000367694.2_Missense_Mutation_p.R164Q|RC3H1_ENST00000258349.4_Missense_Mutation_p.R164Q			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	164					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TGTAACTGTTCGTTCACCTAA	0.512000													13	67					0	0	1	0	0
PRSS53	339105	broad.mit.edu	37	16	31097782	31097782	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr16:31097782C>T	ENST00000280606.6	-	5	692	c.539G>A	c.(538-540)cGt>cAt	p.R180H		NM_001039503.2	NP_001034592.1	Q2L4Q9	PRS53_HUMAN	protease, serine, 53	180	Peptidase S1 1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)|lung(3)	4						ACTGATGAGACGCAGGCGCAG	0.622000													14	52					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51580587	51580587	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr10:51580587G>A	ENST00000452682.1	+	4	473	c.221G>A	c.(220-222)cGt>cAt	p.R74H	NCOA4_ENST00000414907.2_Intron|NCOA4_ENST00000430396.2_5'UTR|NCOA4_ENST00000498586.1_3'UTR|NCOA4_ENST00000344348.6_Missense_Mutation_p.R58H|NCOA4_ENST00000374087.4_Missense_Mutation_p.R58H|NCOA4_ENST00000443446.1_Missense_Mutation_p.R58H|NCOA4_ENST00000374082.1_Missense_Mutation_p.R58H|NCOA4_ENST00000438493.1_Missense_Mutation_p.R74H	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	58					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						TGCATAAGCCGTCACCTGGAA	0.433000			T	RET	papillary thyroid								25	140					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65268712	65268712	+	RNA	SNP	T	T	G			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:65268712T>G	ENST00000534336.1	+	0	3480					NR_002819.2																						TTTGTGGGGGTGGGGGCAAAA	0.393000													8	21					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155450764	155450764	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:155450764C>A	ENST00000368346.3	-	3	2536	c.1897G>T	c.(1897-1899)Gta>Tta	p.V633L	ASH1L_ENST00000392403.3_Missense_Mutation_p.V633L			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	633					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GAATCATTTACCTCTTTATCA	0.353000													6	56					0.00116845	0.00121881	1	1	0
EPHX4	253152	broad.mit.edu	37	1	92528795	92528795	+	Silent	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:92528795C>T	ENST00000370383.4	+	7	1139	c.1041C>T	c.(1039-1041)aaC>aaT	p.N347N		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	347						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						ACATAGTGAACAAATTGATAT	0.313000													7	31					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	48					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26959417	26959417	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr13:26959417T>C	ENST00000381527.3	+	6	1087	c.584T>C	c.(583-585)gTt>gCt	p.V195A	CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	195	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CCAGTGGTTGTTACATTCTGG	0.358000													11	52					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38775449	38775449	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr6:38775449C>T	ENST00000359357.3	+	22	2817	c.2563C>T	c.(2563-2565)Cgg>Tgg	p.R855W	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1072W|DNAH8_ENST00000441566.1_Missense_Mutation_p.R855W					dynein, axonemal, heavy chain 8									p.R855W(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAAAGCTACACGGTTATCTCT	0.328000													8	62					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9003333	9003333	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:9003333C>T	ENST00000397910.4	-	50	40305	c.40102G>A	c.(40102-40104)Gtc>Atc	p.V13368I	MUC16_ENST00000380951.5_Missense_Mutation_p.V9I	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13370	SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGAGCTGACACTGGTGTTC	0.532000													31	51					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10083028	10083028	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr4:10083028C>T	ENST00000382452.2	-	11	1519	c.1237G>A	c.(1237-1239)Gta>Ata	p.V413I	WDR1_ENST00000502702.1_Missense_Mutation_p.V273I|WDR1_ENST00000382451.2_Missense_Mutation_p.V273I|WDR1_ENST00000515743.1_5'UTR|WDR1_ENST00000499869.2_Missense_Mutation_p.V413I	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	413					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CCGACGGCTACGCACTTTGGC	0.572000													13	79					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10265093	10265093	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:10265093G>A	ENST00000340748.4	-	21	2082	c.1847C>T	c.(1846-1848)aCg>aTg	p.T616M	DNMT1_ENST00000359526.4_Missense_Mutation_p.T632M|DNMT1_ENST00000540357.1_Missense_Mutation_p.T616M			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	616					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGTGGCTTTCGTGGGTCCCCT	0.547000													102	141					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764239	82764239	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:82764239G>A	ENST00000423517.2	-	3	2964	c.2627C>T	c.(2626-2628)cCa>cTa	p.P876L	PCLO_ENST00000333891.8_Missense_Mutation_p.P876L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	822	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGGGGGTGTTGGTGACCCTTT	0.517000													52	270					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4619834	4619834	+	Silent	SNP	G	G	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr17:4619834G>C	ENST00000269260.2	+	5	521	c.288G>C	c.(286-288)cgG>cgC	p.R96R	ARRB2_ENST00000381488.6_Silent_p.R81R|ARRB2_ENST00000574954.1_5'UTR|ARRB2_ENST00000412477.3_Silent_p.R96R|ARRB2_ENST00000572457.1_5'UTR|ARRB2_ENST00000346341.2_Silent_p.R81R|ARRB2_ENST00000571206.1_5'UTR|ARRB2_ENST00000575877.1_Silent_p.R96R|ARRB2_ENST00000570718.1_3'UTR	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	96					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding			large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						ACCCACCCCGGCCCCCCACCC	0.672000													7	14					0	0	1	0	0
IFNGR2	3460	broad.mit.edu	37	21	34809233	34809233	+	Silent	SNP	G	G	A	rs17885407	byFrequency	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr21:34809233G>A	ENST00000290219.6	+	7	1626	c.978G>A	c.(976-978)ccG>ccA	p.P326P	TMEM50B_ENST00000468874.2_5'UTR|IFNGR2_ENST00000381995.1_Silent_p.P345P|IFNGR2_ENST00000405436.1_Silent_p.P247P	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	326					regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity	p.P326P(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	TCTCGTTTCCGGAAAAGGAGC	0.502000													6	53					0	0	1	0	0
FXR1	8087	broad.mit.edu	37	3	180688142	180688142	+	Silent	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr3:180688142G>T	ENST00000357559.4	+	15	1983	c.1599G>T	c.(1597-1599)ggG>ggT	p.G533G	FXR1_ENST00000445140.2_Silent_p.G533G|FXR1_ENST00000491062.1_Silent_p.G484G|FXR1_ENST00000468861.1_Silent_p.G448G|FXR1_ENST00000480918.1_Silent_p.G520G|FXR1_ENST00000305586.7_Silent_p.G448G	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	533					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			ATGAAAATGGGCTAGGTATGT	0.323000													7	71					0.00307968	0.00313144	1	1	0
TECPR2	9895	broad.mit.edu	37	14	102898197	102898197	+	Silent	SNP	G	G	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr14:102898197G>T	ENST00000359520.7	+	8	1375	c.1149G>T	c.(1147-1149)ctG>ctT	p.L383L	TECPR2_ENST00000558678.1_Silent_p.L383L	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	383							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CGGAGAAGCTGCCAGGGGCCA	0.582000													7	132					0.00307968	0.00313144	1	1	0
SLC17A9	63910	broad.mit.edu	37	20	61597910	61597910	+	Silent	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr20:61597910G>A	ENST00000370349.3	+	12	1281	c.1077G>A	c.(1075-1077)ccG>ccA	p.P359P	SLC17A9_ENST00000488738.1_3'UTR|SLC17A9_ENST00000370351.4_Silent_p.P365P			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	365					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						ACTTGGCCCCGTCCTGCGCCG	0.647000													45	174					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267060	3267060	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr8:3267060G>C	ENST00000602557.1	-	14	2187	c.1632C>G	c.(1630-1632)ttC>ttG	p.F544L	CSMD1_ENST00000400186.3_Missense_Mutation_p.F544L|CSMD1_ENST00000520002.1_Missense_Mutation_p.F544L|CSMD1_ENST00000542608.1_Missense_Mutation_p.F543L|CSMD1_ENST00000539096.1_Missense_Mutation_p.F543L|CSMD1_ENST00000537824.1_Missense_Mutation_p.F543L|CSMD1_ENST00000602723.1_Missense_Mutation_p.F544L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	544	Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCATGGAGGAAACTGCTGC	0.507000													6	13					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54544333	54544333	+	Splice_Site	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr19:54544333G>A	ENST00000338372.2	-	9	768	c.591_splice	c.e9-1	p.T198_splice	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000376626.1_Splice_Site_p.T167_splice|VSTM1_ENST00000366170.2_Splice_Site_p.T110_splice	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	198						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GGGGTCTGCCGTCTTTGGAGA	0.453000													8	22					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47034444	47034444	+	Silent	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr4:47034444C>T	ENST00000295454.3	+	3	475	c.183C>T	c.(181-183)gtC>gtT	p.V61V	GABRB1_ENST00000509366.1_3'UTR|GABRB1_ENST00000538619.1_Intron	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	61					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCCCCCCGTCGACGTTGGGA	0.627000													46	238					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148907754	148907754	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr7:148907754C>T	ENST00000262085.3	+	5	1015	c.910C>T	c.(910-912)Cgg>Tgg	p.R304W	ZNF282_ENST00000479907.1_Missense_Mutation_p.R304W	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	304					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CCGGGGTCAGCGGGGCCTGGA	0.642000													5	21					0	0	1	0	0
C5orf34	375444	broad.mit.edu	37	5	43506091	43506091	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr5:43506091G>A	ENST00000306862.2	-	4	1066	c.691C>T	c.(691-693)Cac>Tac	p.H231Y	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968.1	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	231										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					ACACATGTGTGCTTTGTACCA	0.423000													15	128					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16960898	16960913	+	RNA	DEL	GTGTGTGTGTGTGTGC	GTGTGTGTGTGTGTGC	-	rs71703041	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:16960898_16960913delGTGTGTGTGTGTGTGC	ENST00000412962.1	-	0	16																											gtgtgtgtgtgtgtgtgtgtgtgtgcgcgtgtgtgA	0.431													2	4	---	---	---	---					
SFN	2810	broad.mit.edu	37	1	27190360	27190363	+	Frame_Shift_Del	DEL	CATG	CATG	-			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr1:27190360_27190363delCATG	ENST00000339276.4	+	1	728_731	c.657_660delCATG	c.(655-660)atfs	p.IM219fs		NM_006142.3	NP_006133.1	P31947	1433S_HUMAN	stratifin	219					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	9		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GCACCCTCATCATGCAGCTGCTGC	0.642													30	166	---	---	---	---					
ZNF660	285349	broad.mit.edu	37	3	44636019	44636019	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr3:44636019delG	ENST00000322734.2	+	3	667	c.334delG	c.(334-336)ggfs	p.G112fs	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CAGTGAATGTGGGAAATCTTT	0.438													19	105	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995077	146995077	+	RNA	DEL	A	A	-			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr3:146995077delA	ENST00000473299.1	-	0	132																											TCTGGACTGtaaaaaaaaaaa	0.294													3	5	---	---	---	---					
AQP11	282679	broad.mit.edu	37	11	77301070	77301072	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr11:77301070_77301072delGCA	ENST00000313578.3	+	1	391_393	c.33_35delGCA	c.(31-36)ctg>ct	p.LQ11del	AQP11_ENST00000528638.1_Intron	NM_173039.2	NP_766627.1	Q8NBQ7	AQP11_HUMAN	aquaporin 11	11						cell surface|integral to membrane	transporter activity			kidney(2)|large_intestine(1)|lung(5)	8	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GGTCCGAGCTGCAGGACACCTGC	0.724													9	37	---	---	---	---					
PRKD1	5587	broad.mit.edu	37	14	30396622	30396623	+	In_Frame_Ins	INS	-	-	CCCGGA	rs139860047	by1000genomes	TCGA-CN-A63V-01A-11D-A28R-08	TCGA-CN-A63V-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	638b8daa-53b7-47ca-847e-542e7f7f439a	b76a5229-61b4-4820-ae31-f656156779f0	g.chr14:30396622_30396623insCCCGGA	ENST00000331968.5	-	1	325_326	c.96_97insTCCGGG	c.(94-99)ggccgg>ggTCCGGGccgg	p.35_36insGP	PRKD1_ENST00000415220.2_In_Frame_Ins_p.35_36insGP	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	35					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GCGGGCCCGGGCCCGGACCCTG	0.762													3	3	---	---	---	---					
