Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RBBP4	5928	broad.mit.edu	37	1	33138283	33138283	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:33138283G>A	ENST00000373493.5	+	10	1243	c.1084G>A	c.(1084-1086)Ggg>Agg	p.G362R	RBBP4_ENST00000373485.1_Missense_Mutation_p.G362R|RBBP4_ENST00000414241.3_Missense_Mutation_p.G361R|RBBP4_ENST00000544435.1_Missense_Mutation_p.G110R|RBBP4_ENST00000458695.2_Missense_Mutation_p.G327R	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	362					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TGCAGAAGACGGGCCACCAGA	0.368000													3	25					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170805171	170805171	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:170805171C>T	ENST00000436636.2	-	24	3190	c.2846G>A	c.(2845-2847)cGc>cAc	p.R949H	TNIK_ENST00000470834.1_Missense_Mutation_p.R912H|TNIK_ENST00000341852.6_Missense_Mutation_p.R865H|TNIK_ENST00000460047.1_Missense_Mutation_p.R886H|TNIK_ENST00000488470.1_Missense_Mutation_p.R894H|TNIK_ENST00000369326.5_Missense_Mutation_p.R927H|TNIK_ENST00000357327.5_Missense_Mutation_p.R920H|TNIK_ENST00000284483.8_Missense_Mutation_p.R941H|TNIK_ENST00000538048.1_Missense_Mutation_p.R901H|TNIK_ENST00000475336.1_Missense_Mutation_p.R857H	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	949	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTTGAGACGCGCCCCAGTCC	0.582000													7	75					0	0	1	0	0
NRN1	51299	broad.mit.edu	37	6	6002627	6002627	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr6:6002627C>T	ENST00000244766.2	-	2	376	c.159G>A	c.(157-159)ccG>ccA	p.P53P	NRN1_ENST00000495850.1_5'UTR	NM_016588.2	NP_057672.1	Q9NPD7	NRN1_HUMAN	neuritin 1	53						anchored to membrane|plasma membrane				endometrium(2)|large_intestine(2)|lung(4)	8	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		CCAGGCCCTGCGGGTAGTTGG	0.602000													6	63					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807419	20807419	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:20807419C>G	ENST00000601440.1	-	4	1410	c.1264G>C	c.(1264-1266)Gag>Cag	p.E422Q	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TAGGGTCTCTCTCCAGTATGA	0.378000													5	26					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90651171	90651171	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:90651171G>C	ENST00000282146.4	+	2	1492	c.1051G>C	c.(1051-1053)Gac>Cac	p.D351H		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	351						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CTCCATGAAGGACTTGCTGGC	0.627000													10	36					0	0	1	0	0
GPM6A	2823	broad.mit.edu	37	4	176622894	176622894	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr4:176622894C>A	ENST00000280187.7	-	3	107	c.62G>T	c.(61-63)tGc>tTc	p.C21F	GPM6A_ENST00000506894.1_Missense_Mutation_p.C10F|GPM6A_ENST00000515090.1_Missense_Mutation_p.C14F|GPM6A_ENST00000393658.2_Missense_Mutation_p.C21F	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	21						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GCCCCCCAGGCATTTGATACA	0.433000													6	67					0.000157383	0.000164938	1	1	0
PSAP	5660	broad.mit.edu	37	10	73591605	73591605	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr10:73591605C>T	ENST00000394936.3	-	3	394	c.247G>A	c.(247-249)Gag>Aag	p.E83K	PSAP_ENST00000394934.1_Missense_Mutation_p.E83K			P07602	SAP_HUMAN	prosaposin	83	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						CCGCTCACCTCAGTGGCATTG	0.512000													14	108					0	0	1	0	0
MAP3K2	10746	broad.mit.edu	37	2	128066276	128066276	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:128066276G>A	ENST00000409947.1	-	16	1801	c.1519C>T	c.(1519-1521)Cgg>Tgg	p.R507W	MAP3K2_ENST00000344908.5_Missense_Mutation_p.R507W			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	507	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GTCTGAAGCCGTTTGCTGGCC	0.458000													6	100					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107642158	107642158	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:107642158G>A	ENST00000393561.1	-	1	314	c.130C>T	c.(130-132)Cgc>Tgc	p.R44C	LAMB1_ENST00000222399.6_Missense_Mutation_p.R20C|LAMB1_ENST00000393560.1_Missense_Mutation_p.R20C			P07942	LAMB1_HUMAN	laminin, beta 1	20	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCTGAGCGCGCACTCGGGCT	0.642000													3	21					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	31030518	31030518	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:31030518C>T	ENST00000298139.5	+	35	4448	c.4199C>T	c.(4198-4200)tCt>tTt	p.S1400F	RP11-363L24.3_ENST00000521252.1_RNA|RP11-363L24.3_ENST00000523365.1_RNA	NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1400					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CAGACTTCATCTGCAGAGAGA	0.358000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				9	44					0	0	1	0	0
MPP2	4355	broad.mit.edu	37	17	41958921	41958921	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:41958921G>A	ENST00000269095.4	-	7	1022	c.718C>T	c.(718-720)Cga>Tga	p.R240*	MPP2_ENST00000377184.3_Nonsense_Mutation_p.R257*|MPP2_ENST00000523501.1_Nonsense_Mutation_p.R229*|MPP2_ENST00000518766.1_Nonsense_Mutation_p.R285*|MPP2_ENST00000461854.1_Nonsense_Mutation_p.R264*|MPP2_ENST00000520305.1_Nonsense_Mutation_p.R101*|MPP2_ENST00000536246.1_Nonsense_Mutation_p.R229*	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365.3	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	264	PDZ.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		AGGCTGTCTCGGGCCGGGTCA	0.582000													5	41					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79514274	79514274	+	Missense_Mutation	SNP	C	C	T	rs35394179		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:79514274C>T	ENST00000537152.1	-	5	1906	c.1381G>A	c.(1381-1383)Ggg>Agg	p.G461R	C17orf70_ENST00000425898.2_Missense_Mutation_p.G261R|C17orf70_ENST00000327787.8_Missense_Mutation_p.G612R	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	612					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GCAAGGGCCCCGCCCACCACC	0.672000													7	65					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656621	40656621	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:40656621C>A	ENST00000406785.1	-	2	989	c.800G>T	c.(799-801)cGa>cTa	p.R267L	SLC8A1_ENST00000402441.1_Missense_Mutation_p.R267L|SLC8A1_ENST00000408028.2_Missense_Mutation_p.R267L|SLC8A1_ENST00000542024.1_Missense_Mutation_p.R267L|SLC8A1_ENST00000332839.4_Missense_Mutation_p.R267L|SLC8A1_ENST00000542756.1_Missense_Mutation_p.R267L|SLC8A1_ENST00000406391.2_Missense_Mutation_p.R267L|SLC8A1_ENST00000405269.1_Missense_Mutation_p.R267L|SLC8A1_ENST00000403092.1_Missense_Mutation_p.R267L|SLC8A1_ENST00000405901.3_Missense_Mutation_p.R267L			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	267	Calmodulin-binding (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.R267L(2)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTTGCCAGCTCGATACCTCTT	0.433000													100	123					7.62712e-44	8.39624e-44	1	1	0
VAV1	7409	broad.mit.edu	37	19	6850734	6850734	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:6850734G>A	ENST00000304076.2	+	23	2211	c.2117G>A	c.(2116-2118)cGg>cAg	p.R706Q	VAV1_ENST00000599806.1_Missense_Mutation_p.R673Q|VAV1_ENST00000539284.1_Missense_Mutation_p.R631Q|VAV1_ENST00000596764.1_Missense_Mutation_p.R696Q|VAV1_ENST00000602142.1_Missense_Mutation_p.R728Q	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	728	SH2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GGACTGTACCGGATCACAGAG	0.552000													4	28					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814845	106814845	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:106814845G>A	ENST00000407775.2	+	8	2785	c.2535G>A	c.(2533-2535)acG>acA	p.T845T	RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000378472.4_Silent_p.T576T|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.T713T|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Silent_p.T713T	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	845					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GGACGACCACGTCTCCCAAAA	0.478000													9	12					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100549486	100549486	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:100549486T>C	ENST00000379458.4	+	2	67	c.67T>C	c.(67-69)Tta>Cta	p.23_23insL	MUC3A_ENST00000483366.1_3'UTR					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGCAGGAACTTTATCCACGGC	0.527000													35	76					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118475631	118475631	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr6:118475631T>A	ENST00000360388.4	+	2	398	c.197T>A	c.(196-198)cTa>cAa	p.L66Q		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	66					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TCTGTGGCCCTAGGCCAGGTG	0.418000													6	77					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	29					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23567243	23567243	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:23567243G>A	ENST00000319074.4	+	2	1232	c.376G>A	c.(376-378)Gtg>Atg	p.V126M	C14orf119_ENST00000554203.1_Missense_Mutation_p.V126M	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	126										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		GCCAGACTTCGTGGCAAAGTT	0.498000													8	72					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935708	30935708	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:30935708G>A	ENST00000355537.3	+	2	1386	c.1239G>A	c.(1237-1239)gtG>gtA	p.V413V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGGTGCCTGTGCCCATGGGCG	0.622000													7	37					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36041995	36041995	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:36041995G>A	ENST00000262623.3	-	20	2932	c.2904C>T	c.(2902-2904)atC>atT	p.I968I		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	968					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACACGATGGCGATCACCAGGA	0.552000													9	7					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121662313	121662313	+	Silent	SNP	T	T	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr10:121662313T>G	ENST00000369075.3	+	3	771	c.699T>G	c.(697-699)gtT>gtG	p.V233V	SEC23IP_ENST00000543134.1_Silent_p.V22V	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	233	Interaction with SEC23A.|Pro-rich.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CCCTCCAGGTTCCTTCTTCAG	0.468000													19	52					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61778373	61778373	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:61778373G>A	ENST00000423902.2	+	38	9354	c.8875G>A	c.(8875-8877)Gag>Aag	p.E2959K	CHD7_ENST00000524602.1_Missense_Mutation_p.E910K	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2959					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAGCGATGCCGAGGAGAGCCT	0.522000													6	32					0	0	1	0	0
EIF2A	83939	broad.mit.edu	37	3	150285973	150285973	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:150285973G>A	ENST00000460851.1	+	9	814	c.705G>A	c.(703-705)gtG>gtA	p.V235V	SERP1_ENST00000490945.1_Intron|EIF2A_ENST00000487799.1_Silent_p.V210V|EIF2A_ENST00000406576.3_Silent_p.V174V|SERP1_ENST00000479209.1_Intron|EIF2A_ENST00000383043.3_Silent_p.V21V|EIF2A_ENST00000273435.5_Silent_p.V230V			Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A, 65kDa	235					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding			cervix(1)|endometrium(2)|kidney(1)|lung(3)	7		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTACTGCTGTGTTGGTAATAG	0.353000													9	36					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122729266	122729266	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr12:122729266C>T	ENST00000267199.4	-	7	931	c.819G>A	c.(817-819)caG>caA	p.Q273Q	RP11-512M8.5_ENST00000535844.1_Silent_p.Q234Q	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	273					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CACCATCGCCCTGTTTCTTAG	0.488000													12	67					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114079468	114079468	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr13:114079468C>G	ENST00000356501.4	-	5	602	c.427G>C	c.(427-429)Gaa>Caa	p.E143Q	ADPRHL1_ENST00000375418.3_Missense_Mutation_p.E225Q	NM_199162.1	NP_954631.1	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	225					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CATTTAGCTTCAAAGTAAAAC	0.443000													5	67					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580445	40580445	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:40580445T>A	ENST00000450241.2	-	6	2113	c.1802A>T	c.(1801-1803)cAc>cTc	p.H601L	ZNF780A_ENST00000594395.1_Missense_Mutation_p.H636L|ZNF780A_ENST00000455521.1_Missense_Mutation_p.H636L|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000595687.2_Missense_Mutation_p.H635L|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000340963.5_Missense_Mutation_p.H635L			O75290	Z780A_HUMAN	zinc finger protein 780A	635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTCACCTGTGTGAATGTTCTT	0.413000													13	64					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544994	82544994	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:82544994C>G	ENST00000423517.2	-	7	12645	c.12308G>C	c.(12307-12309)aGa>aCa	p.R4103T	PCLO_ENST00000437081.1_Missense_Mutation_p.R823T|PCLO_ENST00000333891.8_Missense_Mutation_p.R4103T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4034					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACTATGCAATCTAGAGGAAGA	0.448000													3	31					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530548	84530548	+	RNA	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr9:84530548G>A	ENST00000527857.1	+	0	570					NR_026851.1																						AACCACTCCAGAAGACCTAAT	0.512000													4	33					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58508313	58508313	+	Silent	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:58508313T>C	ENST00000302819.5	-	12	1833	c.1542A>G	c.(1540-1542)tcA>tcG	p.S514S	ACOX2_ENST00000481527.1_5'UTR|ACOX2_ENST00000459701.2_Silent_p.S500S	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	514					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		AATGCTGCACTGAGTCCTTTA	0.522000													8	33					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230725191	230725191	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:230725191G>C	ENST00000389044.4	-	3	323	c.155C>G	c.(154-156)tCt>tGt	p.S52C	TRIP12_ENST00000409677.1_Missense_Mutation_p.S52C|TRIP12_ENST00000283943.5_Intron|TRIP12_ENST00000389045.3_Intron|TRIP12_ENST00000543084.1_Missense_Mutation_p.S52C			Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	34					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTTAGAATTAGATTTTCTACT	0.383000													15	69					0	0	1	0	0
NXPH3	11248	broad.mit.edu	37	17	47656174	47656174	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:47656174C>T	ENST00000328741.5	+	2	633	c.271C>T	c.(271-273)Cca>Tca	p.P91S	NXPH3_ENST00000513748.1_Missense_Mutation_p.P91S	NM_007225.2	NP_009156.2	O95157	NXPH3_HUMAN	neurexophilin 3	91	III.				neuropeptide signaling pathway	extracellular region				endometrium(2)|large_intestine(3)|lung(4)|pancreas(1)|skin(2)	12	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CCACAGCCCCCCACCCTCAGC	0.627000													9	35					0	0	1	0	0
RBBP7	5931	broad.mit.edu	37	X	16871871	16871871	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chrX:16871871T>A	ENST00000380087.2	-	6	1052	c.692A>T	c.(691-693)gAt>gTt	p.D231V	RBBP7_ENST00000380084.4_Missense_Mutation_p.D275V|RBBP7_ENST00000404022.1_Missense_Mutation_p.D222V			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	231					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					CCAGGCCACATCCTCTACAAC	0.433000													8	33					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203374	155203374	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:155203374G>A	ENST00000460012.1	-	22	3012	c.2655C>T	c.(2653-2655)agC>agT	p.S885S	PLCH1_ENST00000447496.2_Silent_p.S923S|PLCH1_ENST00000414191.1_Silent_p.S885S|PLCH1_ENST00000340059.7_Silent_p.S923S|PLCH1_ENST00000334686.6_Silent_p.S885S|PLCH1_ENST00000494598.1_Silent_p.S903S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	923					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGGCTGGGGCGCTAGCTGTGC	0.473000													4	66					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73489130	73489130	+	Missense_Mutation	SNP	G	G	T	rs142640709		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:73489130G>T	ENST00000314256.7	+	16	2427	c.2033G>T	c.(2032-2034)cGg>cTg	p.R678L	KIAA0195_ENST00000375248.5_Missense_Mutation_p.R688L|KIAA0195_ENST00000579208.1_Missense_Mutation_p.R329L	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	678					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTCACCAAGCGGCGGCCTCCC	0.602000													8	40					5.18039e-06	5.51733e-06	1	1	0
JAKMIP3	282973	broad.mit.edu	37	10	133966476	133966476	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr10:133966476G>A	ENST00000298622.4	+	16	2154	c.2016G>A	c.(2014-2016)gaG>gaA	p.E672E	JAKMIP3_ENST00000477275.1_3'UTR	NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGACCAATGAGGAGCAGGTGG	0.582000													2	1					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302858	123302858	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:123302858A>T	ENST00000458573.2	+	2	1375	c.1218A>T	c.(1216-1218)aaA>aaT	p.K406N	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	406	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding										TCCCCAAAAAAGTCCAGACTG	0.567000													7	42					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29933536	29933536	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr13:29933536G>A	ENST00000431530.3	+	6	3131	c.3073G>A	c.(3073-3075)Gcg>Acg	p.A1025T		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1015	Localization to the growing distal tip of microtubules.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GCTGGGCGTTGCGCAAGGGGA	0.642000													5	16					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15319196	15319196	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:15319196C>T	ENST00000281513.5	-	51	6781	c.6756G>A	c.(6754-6756)ctG>ctA	p.L2252L	NBAS_ENST00000441750.1_Silent_p.L2132L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	2252										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GAGATGGAAGCAGGAGGGACT	0.552000													6	48					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561319	44561319	+	Missense_Mutation	SNP	T	T	A	rs146911955	byFrequency	TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr18:44561319T>A	ENST00000332567.4	-	1	669	c.317A>T	c.(316-318)cAg>cTg	p.Q106L	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	106					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding	p.Q106R(1)		breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GGCCTTTTCCTGGTCCTGAAG	0.652000													20	47					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727541	7727541	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr6:7727541A>T	ENST00000283147.6	+	1	512	c.353A>T	c.(352-354)cAg>cTg	p.Q118L		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	118					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.Q118L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					cagcagcagcagcTGCCTCGC	0.731000													3	19					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23765013	23765013	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr9:23765013C>T	ENST00000380110.4	-	2	133	c.66G>A	c.(64-66)tgG>tgA	p.W22*	ELAVL2_ENST00000544538.1_Intron|ELAVL2_ENST00000380117.1_Intron|ELAVL2_ENST00000223951.6_Intron|ELAVL2_ENST00000397312.2_Intron			Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	0					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		AGACCCCGGTCCAAGGCTCTG	0.463000													6	64					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200193463	200193463	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:200193463G>A	ENST00000443023.1	-	7	2632	c.1167C>T	c.(1165-1167)gtC>gtT	p.V389V	RP11-486F17.1_ENST00000489557.2_RNA|SATB2_ENST00000428695.1_Silent_p.V330V|SATB2_ENST00000457245.1_Silent_p.V448V|SATB2_ENST00000417098.1_Silent_p.V448V|SATB2_ENST00000260926.5_Silent_p.V448V			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	448						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGGCCGAGGAGACCATGCTCA	0.527000													8	55					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129828664	129828664	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr6:129828664A>C	ENST00000421865.2	+	62	8783	c.8734A>C	c.(8734-8736)Aat>Cat	p.N2912H		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2912	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGCGTCAGGAATCTCCACAT	0.453000													13	87					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423388	26423388	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr22:26423388C>A	ENST00000335473.7	+	43	7698	c.7448C>A	c.(7447-7449)tCc>tAc	p.S2483Y	MYO18B_ENST00000407587.2_Missense_Mutation_p.S2484Y|MYO18B_ENST00000536101.1_Missense_Mutation_p.S2483Y	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2483						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCTAACCGTTCCTTTCTCTCG	0.562000													5	38					1	1	1	1	0
TRGV4	6977	broad.mit.edu	37	7	38393543	38393543	+	RNA	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:38393543G>C	ENST00000390345.2	-	0	460																											CCTTCAGCAAGATCACAAGTG	0.512000													8	87					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026749	79026749	+	Silent	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr5:79026749T>C	ENST00000446378.2	+	2	2192	c.2161T>C	c.(2161-2163)Tta>Cta	p.L721L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	721						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TAAGTCCCCGTTAATATTGAA	0.453000													6	37					0	0	1	0	0
CASP4	837	broad.mit.edu	37	11	104821749	104821749	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr11:104821749G>A	ENST00000444739.2	-	4	1359	c.449C>T	c.(448-450)cCt>cTt	p.P150L	CASP4_ENST00000531333.1_5'UTR|CASP4_ENST00000393150.3_Missense_Mutation_p.P94L	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	150					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		ATTCCTCGGAGGCAGATGGTC	0.463000													9	91					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80158520	80158520	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:80158520C>A	ENST00000428277.2	+	4	992	c.606C>A	c.(604-606)aaC>aaA	p.N202K	NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000335750.5_Intron|NRXN3_ENST00000281127.7_Intron|NRXN3_ENST00000557594.1_Intron|NRXN3_ENST00000554719.1_Intron|RP11-242P2.1_ENST00000553322.1_RNA	NM_001105250.1	NP_001098720.1	Q9HDB5	NRX3B_HUMAN	neurexin 3	200	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTAAAGGCAACACTGATAATG	0.328000													3	19					0.004672	0.0047815	1	1	0
SOX17	64321	broad.mit.edu	37	8	55370808	55370808	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:55370808G>T	ENST00000297316.4	+	1	314	c.110G>T	c.(109-111)aGc>aTc	p.S37I		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	37					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			GAGTCGCTGAGCCCCATCGGG	0.751000													3	15					0.004672	0.0047815	1	1	0
FGF9	2254	broad.mit.edu	37	13	22246293	22246293	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr13:22246293C>G	ENST00000382353.5	+	1	772	c.242C>G	c.(241-243)aCt>aGt	p.T81S		NM_002010.2	NP_002001.1	P31371	FGF9_HUMAN	fibroblast growth factor 9	81					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(2)	9		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		CCCAATGGTACTATCCAGGGA	0.458000													11	52					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045748	26045748	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr6:26045748A>T	ENST00000540144.1	+	1	110	c.110A>T	c.(109-111)aAg>aTg	p.K37M		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GGTGGCGTGAAGAAACCTCAT	0.632000													11	26					0	0	1	0	0
SPATA12	353324	broad.mit.edu	37	3	57107805	57107805	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:57107805G>C	ENST00000334325.1	+	2	758	c.83G>C	c.(82-84)aGa>aCa	p.R28T	ARHGEF3_ENST00000338458.4_Intron	NM_181727.1	NP_859078.1	Q7Z6I5	SPT12_HUMAN	spermatogenesis associated 12	28										large_intestine(2)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0111)|Kidney(284;0.0129)		GACTCTTCCAGACTCGTTCCA	0.552000													8	36					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29001349	29001349	+	Missense_Mutation	SNP	T	T	G	rs151270578		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr13:29001349T>G	ENST00000282397.4	-	10	1634	c.1383A>C	c.(1381-1383)caA>caC	p.Q461H	FLT1_ENST00000541932.1_Missense_Mutation_p.Q461H|FLT1_ENST00000539099.1_Missense_Mutation_p.Q461H	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	461	Ig-like C2-type 5.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGATTGTAGGTTGAGGGATAC	0.463000													4	67					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240192	167240192	+	Silent	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:167240192T>C	ENST00000308378.3	-	12	1934	c.1629A>G	c.(1627-1629)gaA>gaG	p.E543E	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Intron|WDR49_ENST00000476376.1_Silent_p.E368E	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	543										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						ATAAAGAAATTTCCTTTTGAA	0.313000													8	43					0	0	1	0	0
WIPI1	55062	broad.mit.edu	37	17	66423284	66423284	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:66423284G>A	ENST00000262139.5	-	11	1183	c.1184C>T	c.(1183-1185)aCg>aTg	p.T395M	RP11-120M18.2_ENST00000592030.1_RNA|WIPI1_ENST00000589459.1_5'UTR|WIPI1_ENST00000546360.1_Missense_Mutation_p.T313M	NM_017983.5	NP_060453.3	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting 1	395					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	18						ACCTGGCACCGTGGAGGCTGA	0.567000													5	63					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31599400	31599400	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr18:31599400G>A	ENST00000261592.5	-	6	1235	c.938C>T	c.(937-939)gCg>gTg	p.A313V	NOL4_ENST00000535384.1_Missense_Mutation_p.A28V|NOL4_ENST00000538587.1_Missense_Mutation_p.A239V|NOL4_ENST00000535475.1_Missense_Mutation_p.A158V|NOL4_ENST00000269185.4_Missense_Mutation_p.A199V|NOL4_ENST00000589544.1_Missense_Mutation_p.A313V	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	313						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						AGTTAGCTGCGCAGAGAGGGG	0.473000													25	42					0	0	1	0	0
CKMT1B	1159	broad.mit.edu	37	15	43891412	43891412	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr15:43891412C>T	ENST00000300283.6	+	10	1587	c.1195C>T	c.(1195-1197)Cgt>Tgt	p.R399C	CKMT1B_ENST00000441322.1_Missense_Mutation_p.R399C	NM_020990.3	NP_066270.1	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B	399	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			large_intestine(1)|lung(3)|skin(1)	5		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	TTGTGAACGGCGTCTGGAGAG	0.498000													10	119					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58123500	58123500	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:58123500C>G	ENST00000184956.6	-	19	2876	c.2860G>C	c.(2860-2862)Gag>Cag	p.E954Q	HEATR6_ENST00000585976.1_Missense_Mutation_p.E842Q	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	954							binding	p.E954Q(1)		NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ATAGACTCCTCAATGATTTCT	0.393000													7	82					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545598	54545598	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr19:54545598G>C	ENST00000338372.2	-	5	595	c.420C>G	c.(418-420)atC>atG	p.I140M	VSTM1_ENST00000376626.1_Intron|VSTM1_ENST00000366170.2_Missense_Mutation_p.I52M|VSTM1_ENST00000425006.2_3'UTR	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	140						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TGCAGCTGAAGATGGCGACAA	0.542000													3	23					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155722	103155722	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:103155722C>T	ENST00000428762.1	-	50	8188	c.8029G>A	c.(8029-8031)Gcc>Acc	p.A2677T	RELN_ENST00000424685.2_Missense_Mutation_p.A2677T|RELN_ENST00000343529.5_Missense_Mutation_p.A2677T	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2677					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGTACTGGGGCGCTGCTGAAG	0.542000													19	25					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733428	152733428	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:152733428G>C	ENST00000368773.1	+	2	1422	c.1364G>C	c.(1363-1365)tGt>tCt	p.C455S	KPRP_ENST00000606109.1_Missense_Mutation_p.C455S	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	455	Pro-rich.					cytoplasm		p.C455Y(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGGGCAGTGTGAGATTCCA	0.612000													14	95					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131219333	131219333	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:131219333G>A	ENST00000264995.3	-	3	457	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L	MRPL3_ENST00000425847.2_Silent_p.L131L	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	104					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						ATCATGCCCAGCTTCAAGGCA	0.388000													4	67					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19460863	19460863	+	Splice_Site	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr16:19460863G>A	ENST00000396229.2	+	5	1707		c.e5-1		TMC5_ENST00000542583.2_Splice_Site|TMC5_ENST00000541464.1_Splice_Site|TMC5_ENST00000381414.4_Splice_Site	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5							integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CTTCCCTCCAGTGAACCCTGC	0.458000													35	70					0	0	1	0	0
ASIC3	9311	broad.mit.edu	37	7	150746472	150746472	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:150746472G>A	ENST00000357922.4	+	1	1094	c.500G>A	c.(499-501)cGt>cAt	p.R167H	ASIC3_ENST00000297512.8_Missense_Mutation_p.R167H|ASIC3_ENST00000349064.5_Missense_Mutation_p.R167H	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	167					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										TGTCGCTTCCGTGGCCAACCT	0.637000													10	63					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174188383	174188383	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:174188383C>T	ENST00000251507.4	+	2	262	c.88C>T	c.(88-90)Cag>Tag	p.Q30*	RABGAP1L_ENST00000357444.6_Intron|RABGAP1L_ENST00000367689.3_Intron	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	30					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						TTTGGTTCCTCAGTATGCAGA	0.318000													7	47					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127396078	127396078	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:127396078C>T	ENST00000468137.1	+	7	901	c.285C>T	c.(283-285)ctC>ctT	p.L95L	ABTB1_ENST00000453791.2_Silent_p.L95L|ABTB1_ENST00000232744.8_Silent_p.L237L|ABTB1_ENST00000393363.3_Silent_p.L95L			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	237						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						ACCCCCGCCTCCGGGAGGACA	0.667000													3	14					0	0	1	0	0
NEK2	4751	broad.mit.edu	37	1	211840550	211840550	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:211840550G>A	ENST00000366999.4	-	7	1147	c.1009C>T	c.(1009-1011)Cgt>Tgt	p.R337C	NEK2_ENST00000366998.3_Missense_Mutation_p.R337C|NEK2_ENST00000540251.1_Missense_Mutation_p.R294C|NEK2_ENST00000462283.1_5'UTR	NM_002497.3	NP_002488.1	P51955	NEK2_HUMAN	NIMA-related kinase 2	337	Interaction with PCNT.|Necessary for interaction with MAD1L1.|Required for microtubule binding and for localization to the centrosomes.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		AGTCTCTCACGAACACAAAGC	0.378000													7	98					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75113085	75113085	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr15:75113085C>G	ENST00000309664.5	+	8	1023	c.884C>G	c.(883-885)tCa>tGa	p.S295*	LMAN1L_ENST00000379709.3_Nonsense_Mutation_p.S283*	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	295						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACTCCAAAATCAGACTCTGAA	0.612000													7	54					0	0	1	0	0
BEND2	139105	broad.mit.edu	37	X	18192182	18192182	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chrX:18192182G>T	ENST00000380033.4	-	12	2081	c.1949C>A	c.(1948-1950)aCt>aAt	p.T650N	BEND2_ENST00000380030.3_Missense_Mutation_p.T559N	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	650										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						TGGATTATCAGTGGAAGGTTC	0.378000													4	26					0.184627	0.186048	1	1	0
CXCR2	3579	broad.mit.edu	37	2	218999925	218999925	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:218999925T>A	ENST00000318507.2	+	3	828	c.401T>A	c.(400-402)aTc>aAc	p.I134N		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	134					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						TATAGTGGCATCCTGCTACTG	0.527000													4	55					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40330439	40330439	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:40330439C>G	ENST00000264661.3	-	3	699	c.367G>C	c.(367-369)Gtc>Ctc	p.V123L	KCNH4_ENST00000607371.1_Missense_Mutation_p.V123L	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	123	PAC.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AACAGCACGACCTCCCCCATC	0.572000													6	32					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910084	35910084	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr5:35910084G>A	ENST00000397367.2	-	4	535	c.409C>T	c.(409-411)Cgt>Tgt	p.R137C	CAPSL_ENST00000397366.1_Missense_Mutation_p.R137C|CAPSL_ENST00000514524.1_Missense_Mutation_p.R137C	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	137	EF-hand 3.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TATACTTCACGAAGGTCTTCG	0.393000													17	100					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96802818	96802818	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr10:96802818C>A	ENST00000371270.3	-	7	1072	c.978G>T	c.(976-978)gaG>gaT	p.E326D	CYP2C8_ENST00000535898.1_Missense_Mutation_p.E224D|CYP2C8_ENST00000539050.1_Missense_Mutation_p.E240D	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	326					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding	p.E326D(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CATGATCAATCTCTTCCTGGA	0.438000													8	57					5.18039e-06	5.51733e-06	1	1	0
GPR37	2861	broad.mit.edu	37	7	124404324	124404324	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:124404324C>T	ENST00000303921.2	-	1	1357	c.707G>A	c.(706-708)cGc>cAc	p.R236H		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	236						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTTTCCCCGGCGGGGACCCCC	0.642000													10	54					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117700104	117700104	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chrX:117700104G>A	ENST00000276204.6	+	8	904	c.830G>A	c.(829-831)aGt>aAt	p.S277N	DOCK11_ENST00000276202.7_Missense_Mutation_p.S277N			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	277					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AACACCGACAGTTTAGTTCAA	0.348000													14	43					0	0	1	0	0
MOB2	81532	broad.mit.edu	37	11	1491582	1491582	+	Silent	SNP	G	G	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr11:1491582G>C	ENST00000329957.6	-	5	816	c.627C>G	c.(625-627)ctC>ctG	p.L209L	MOB2_ENST00000526462.1_5'UTR	NM_001172223.1	NP_001165694.1	Q70IA6	MOB2_HUMAN	MOB kinase activator 2	178						nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|kidney(2)|lung(1)	4						AGTGGACGTAGAGCGTGTTCA	0.597000													9	68					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20885955	20885955	+	Silent	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr12:20885955C>G	ENST00000381552.1	+	10	1667	c.1299C>G	c.(1297-1299)gtC>gtG	p.V433V	SLCO1C1_ENST00000540354.1_Silent_p.V384V|SLCO1C1_ENST00000545102.1_Silent_p.V315V|SLCO1C1_ENST00000545604.1_Silent_p.V433V|SLCO1C1_ENST00000266509.2_Silent_p.V433V			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	433					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					GATCATCTGTCTTTGGTTACC	0.443000													11	91					0	0	1	0	0
SNRNP40	9410	broad.mit.edu	37	1	31769513	31769513	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:31769513C>A	ENST00000263694.4	-	1	104	c.86G>T	c.(85-87)gGg>gTg	p.G29V	SNRNP40_ENST00000446633.2_Missense_Mutation_p.G29V	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	29						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						TGGGCCAGACCCCGCTCCCAA	0.637000													7	49					0.0293803	0.0298358	1	1	0
COTL1	23406	broad.mit.edu	37	16	84623742	84623742	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr16:84623742G>A	ENST00000262428.4	-	3	449	c.287C>T	c.(286-288)aCg>aTg	p.T96M	COTL1_ENST00000564057.1_Missense_Mutation_p.T27M	NM_021149.2	NP_066972.1	Q14019	COTL1_HUMAN	coactosin-like 1 (Dictyostelium)	96	ADF-H.					cytoplasm|cytoskeleton	actin binding|enzyme binding			endometrium(1)|large_intestine(1)|liver(1)|lung(2)|skin(1)	6						GGTCTTGTCCGTCCCGGTTTT	0.602000													11	31					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154393920	154393920	+	Silent	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr5:154393920T>C	ENST00000435029.4	+	1	661	c.501T>C	c.(499-501)ccT>ccC	p.P167P		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	167	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGGAGGATCCTAAGGAAGGCA	0.408000													25	112					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8239292	8239292	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr4:8239292C>T	ENST00000539824.1	+	17	3794	c.3420C>T	c.(3418-3420)ctC>ctT	p.L1140L	SH3TC1_ENST00000245105.3_Silent_p.L1216L			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	1216							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						ACTTCTACCTCAAGGCCCTGT	0.637000													5	13					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458047	248458047	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:248458047C>T	ENST00000317996.1	-	1	833	c.834G>A	c.(832-834)atG>atA	p.M278I		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AAGGGGTGAACATAGTATAGA	0.473000													30	119					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77619532	77619532	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr13:77619532C>G	ENST00000407578.2	-	83	14284	c.14018G>C	c.(14017-14019)aGa>aCa	p.R4673T	MYCBP2_ENST00000544440.2_Missense_Mutation_p.R4635T|MYCBP2_ENST00000357337.6_Missense_Mutation_p.R4635T	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GTGGGCATTTCTGCACACTCC	0.478000													7	40					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578394	7578394	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr17:7578394T>A	ENST00000420246.2	-	5	668	c.536A>T	c.(535-537)cAt>cTt	p.H179L	TP53_ENST00000269305.4_Missense_Mutation_p.H179L|TP53_ENST00000445888.2_Missense_Mutation_p.H179L|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000359597.4_Missense_Mutation_p.H179L|TP53_ENST00000413465.2_Missense_Mutation_p.H179L|TP53_ENST00000455263.2_Missense_Mutation_p.H179L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	179	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(108)|p.H179L(43)|p.P177_C182delPHHERC(8)|p.0?(8)|p.H47L(4)|p.H86L(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.H178_S183delHHERCS(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.H86R(2)|p.H47R(2)|p.R174fs*1(2)|p.H179fs*68(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H46_S51delHHERCS(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H85_S90delHHERCS(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	25					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130694231	130694231	+	Missense_Mutation	SNP	G	G	A	rs137853014		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:130694231G>A	ENST00000510168.1	+	18	2019	c.1469G>A	c.(1468-1470)tGt>tAt	p.C490Y	ATP2C1_ENST00000393221.4_Missense_Mutation_p.C524Y|ATP2C1_ENST00000504381.1_Missense_Mutation_p.C435Y|ATP2C1_ENST00000359644.3_Missense_Mutation_p.C490Y|ATP2C1_ENST00000507488.2_Missense_Mutation_p.C474Y|ATP2C1_ENST00000428331.2_Missense_Mutation_p.C490Y|ATP2C1_ENST00000513801.1_Missense_Mutation_p.C474Y|ATP2C1_ENST00000504948.1_Missense_Mutation_p.C474Y|ATP2C1_ENST00000422190.2_Missense_Mutation_p.C490Y|ATP2C1_ENST00000505330.1_Missense_Mutation_p.C474Y|ATP2C1_ENST00000508532.1_Missense_Mutation_p.C490Y|ATP2C1_ENST00000533801.2_Missense_Mutation_p.C485Y|ATP2C1_ENST00000328560.8_Missense_Mutation_p.C490Y			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	490			C -> F (in HHD).		actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ATTAAGTACTGTACTACATAC	0.423000									Hailey-Hailey disease				13	74					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13421096	13421096	+	Missense_Mutation	SNP	G	G	C	rs149916127		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:13421096G>C	ENST00000254508.5	-	7	1025	c.943C>G	c.(943-945)Ctg>Gtg	p.L315V		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	315					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTCTGTCCCAGCTGCAGTGCA	0.587000													4	41					0	0	1	0	0
ASB2	51676	broad.mit.edu	37	14	94417390	94417390	+	Missense_Mutation	SNP	C	C	T	rs142812400		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:94417390C>T	ENST00000555019.1	-	6	1265	c.835G>A	c.(835-837)Gcc>Acc	p.A279T	ASB2_ENST00000315988.4_Missense_Mutation_p.A231T|ASB2_ENST00000556337.1_Intron	NM_001202429.1	NP_001189358.1	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box containing 2	231					intracellular signal transduction					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(1)	27		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		CCACTCTGGGCGGCCACGAAC	0.587000													20	105					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113176157	113176157	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:113176157C>T	ENST00000295872.4	-	13	1742	c.1483G>A	c.(1483-1485)Gag>Aag	p.E495K		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	495					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GCCACTTCCTCTCTGAACATC	0.443000													4	81					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702585	27702585	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr10:27702585C>T	ENST00000438700.3	-	1	712	c.595G>A	c.(595-597)Gcc>Acc	p.A199T		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	199					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CTCCTGGAGGCGGAGAAGCGG	0.602000													30	85					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488851	20488851	+	RNA	SNP	G	G	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr15:20488851G>T	ENST00000555186.1	+	0	334					NR_038836.1																						TGTTTCTGTTGGGACTGCTGG	0.448000													14	83					1.05317e-09	1.14971e-09	1	1	0
AMOTL2	51421	broad.mit.edu	37	3	134086462	134086462	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:134086462C>T	ENST00000514516.1	-	3	1270	c.1092G>A	c.(1090-1092)tcG>tcA	p.S364S	AMOTL2_ENST00000249883.5_Silent_p.S306S|AMOTL2_ENST00000513145.1_Silent_p.S306S|AMOTL2_ENST00000422605.2_Silent_p.S306S	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	306										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GGGCACTGCCCGAGGTGGCTG	0.677000													14	50					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59410811	59410811	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:59410811A>T	ENST00000301645.3	-	2	435	c.298T>A	c.(298-300)Ttt>Att	p.F100I		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	100			F -> S.		bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GCAAAGTGAAATTTTTTCCAA	0.323000									Neonatal Giant Cell Hepatitis				9	101					0	0	1	0	0
PCYOX1	51449	broad.mit.edu	37	2	70503972	70503972	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:70503972G>A	ENST00000433351.2	+	6	994	c.966G>A	c.(964-966)tcG>tcA	p.S322S	PCYOX1_ENST00000545138.1_Silent_p.S244S|PCYOX1_ENST00000264441.5_Intron|PCYOX1_ENST00000505044.2_Silent_p.S245S	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	322					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						GAAAAATGTCGAATATTACTT	0.368000													4	46					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98392478	98392478	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:98392478T>C	ENST00000186436.5	-	32	4376	c.4148A>G	c.(4147-4149)aAa>aGa	p.K1383R		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1383	Lys-rich.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AGGTTTTCCTTTCCCTGAGGA	0.438000													5	36					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33596524	33596524	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr20:33596524C>A	ENST00000252015.2	-	13	1627	c.1538G>T	c.(1537-1539)gGc>gTc	p.G513V	TRPC4AP_ENST00000432634.2_Missense_Mutation_p.G474V|TRPC4AP_ENST00000539834.1_Missense_Mutation_p.G115V|TRPC4AP_ENST00000451813.1_Missense_Mutation_p.G505V			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	513					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGTTAATAAGCCCCTCTTCCC	0.537000													6	66					0.00116845	0.00121481	1	1	0
IFNAR1	3454	broad.mit.edu	37	21	34727622	34727622	+	Splice_Site	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr21:34727622T>C	ENST00000270139.3	+	11	1593	c.1440_splice	c.e11-1	p.Y481_splice	IFNAR1_ENST00000442357.2_Splice_Site_p.Y420_splice|IFNAR1_ENST00000416947.2_Splice_Site_p.Y412_splice	NM_000629.2	NP_000620.2	P17181	INAR1_HUMAN	interferon (alpha, beta and omega) receptor 1	481					JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTTAAATTAGTATTTCTCTGA	0.274000													7	23					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3845297	3845297	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr20:3845297G>A	ENST00000428216.2	+	6	1148	c.1020G>A	c.(1018-1020)gcG>gcA	p.A340A	MAVS_ENST00000416600.2_Silent_p.A199A|MAVS_ENST00000358134.6_3'UTR	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	340					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CTTCTAATGCGCTCACCAATC	0.562000													7	87					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17482118	17482118	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr11:17482118C>T	ENST00000302539.4	-	6	1053	c.928G>A	c.(928-930)Gac>Aac	p.D310N	ABCC8_ENST00000389817.3_Missense_Mutation_p.D310N	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	310	ABC transmembrane type-1 1.		D -> N (in HHF1).		carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCCAGCAGGTCGGCCAAGATG	0.647000													9	54					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8722154	8722154	+	Silent	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr20:8722154G>A	ENST00000378641.3	+	23	2932	c.2457G>A	c.(2455-2457)ctG>ctA	p.L819L	PLCB1_ENST00000378637.2_Silent_p.L819L|PLCB1_ENST00000338037.6_Silent_p.L819L|PLCB1_ENST00000494924.1_3'UTR	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	819					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ATGTGAACCTGATGGAACAGA	0.368000													3	36					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35453023	35453023	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:35453023C>T	ENST00000357182.4	-	16	3887	c.3660G>A	c.(3658-3660)atG>atA	p.M1220I	ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1220					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TTTGGTGATTCATAAAAGGGT	0.368000													12	57					0	0	1	0	0
BTNL3	10917	broad.mit.edu	37	5	180424310	180424310	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr5:180424310C>T	ENST00000342868.6	+	3	679	c.495C>T	c.(493-495)gcC>gcT	p.A165A		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	165	Ig-like V-type.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			AGCCCACAGCCAAGTGGAAAG	0.522000													11	53					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350592	100350592	+	RNA	SNP	T	T	C	rs112032841		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:100350592T>C	ENST00000542585.1	+	0	3012				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGAAAAACTCACCATCCCC	0.512000													9	92					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140400147	140400147	+	Silent	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr9:140400147C>A	ENST00000406427.1	-	14	1728	c.1392G>T	c.(1390-1392)acG>acT	p.T464T	PNPLA7_ENST00000277531.4_Silent_p.T439T|PNPLA7_ENST00000371457.1_Silent_p.T45T	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	439				FLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETL ASRKSDAIFRAAKKDLLTLMKLEDSSLLDG -> LCLLPQC LGGLPPTDTSVYSSASSDCCGCSMPVLCIMGHKPHVTVDT (in Ref. 1; BAC86509).	lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGGTCTCATCCGTGTGACTCT	0.587000													5	101					1.23904e-05	1.30899e-05	1	1	0
NFIB	4781	broad.mit.edu	37	9	14150263	14150263	+	Splice_Site	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr9:14150263C>T	ENST00000380959.3	-	5	1160	c.685_splice	c.e5-1	p.T229_splice	NFIB_ENST00000543693.1_5'UTR|NFIB_ENST00000397575.3_Splice_Site_p.T229_splice|NFIB_ENST00000380953.1_Splice_Site_p.T229_splice|NFIB_ENST00000397581.2_Splice_Site_p.T229_splice|NFIB_ENST00000397579.2_Splice_Site_p.T229_splice|NFIB_ENST00000380924.1_5'UTR|NFIB_ENST00000380934.4_Splice_Site_p.T255_splice	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	229					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GGGTTATGGGCGCTGAGGAAT	0.438000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								93	88					0	0	1	0	0
ARL5A	26225	broad.mit.edu	37	2	152659794	152659794	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:152659794C>G	ENST00000295087.8	-	6	847	c.536G>C	c.(535-537)aGa>aCa	p.R179T	ARL5A_ENST00000428992.2_Missense_Mutation_p.R142T	NM_001037174.1|NM_012097.3	NP_001032251.1|NP_036229.1	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A	179					small GTPase mediated signal transduction	intracellular	GTP binding			breast(1)|large_intestine(2)|liver(1)|lung(2)	6				BRCA - Breast invasive adenocarcinoma(221;0.153)		TAGAGATCATCTAATCTTAAG	0.313000													4	27					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5145467	5145467	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr16:5145467C>T	ENST00000427587.4	-	2	213	c.145G>A	c.(145-147)Gat>Aat	p.D49N	FAM86A_ENST00000458008.4_Missense_Mutation_p.D49N|FAM86A_ENST00000587133.1_Missense_Mutation_p.D49N	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	49										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						TGCAAAATATCCCGCAGCAGC	0.488000													7	60					0	0	1	0	0
CALM2	805	broad.mit.edu	37	2	47389661	47389661	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr2:47389661C>G	ENST00000272298.7	-	3	332	c.175G>C	c.(175-177)Gat>Cat	p.D59H	CALM2_ENST00000409563.1_Missense_Mutation_p.D106H|CALM2_ENST00000422269.1_Intron	NM_001743.4	NP_001734.1	P62158	CALM_HUMAN	calmodulin 2 (phosphorylase kinase, delta)	59	EF-hand 2.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding	p.0?(2)		kidney(1)|large_intestine(2)|lung(1)|skin(1)	5		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	GACTTACCATCAGCATCTACT	0.398000													5	101					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75078171	75078171	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:75078171C>T	ENST00000261978.4	-	1	863	c.477G>A	c.(475-477)ccG>ccA	p.P159P	LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Silent_p.P159P	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	159					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCCGCCCTCGCGGCGGGGTTG	0.731000													7	17					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31242413	31242413	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr12:31242413G>A	ENST00000407793.2	+	8	1120	c.869G>A	c.(868-870)aGa>aAa	p.R290K	DDX11_ENST00000228264.6_Missense_Mutation_p.R264K|DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000545668.1_Missense_Mutation_p.R290K|DDX11_ENST00000350437.4_Missense_Mutation_p.R290K|DDX11_ENST00000542838.1_Missense_Mutation_p.R290K	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	290	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GACATGCAGAGAAGCAGGCAC	0.517000										Multiple Myeloma(12;0.14)			3	28					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785713	12785713	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:12785713C>T	ENST00000332530.3	+	3	819	c.593C>T	c.(592-594)cCc>cTc	p.P198L	AADACL3_ENST00000359318.5_Missense_Mutation_p.P268L	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	268							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ATGTGCTCGCCCCTGATTGCA	0.493000													14	55					0	0	1	0	0
ALG1L	200810	broad.mit.edu	37	3	125652459	125652459	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:125652459C>T	ENST00000340333.3	-	2	222	c.59G>A	c.(58-60)cGc>cAc	p.R20H		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	20							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						TGGCCACTCGCGGAGATGCAT	0.622000													6	20					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154898213	154898213	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr3:154898213T>C	ENST00000460393.1	+	23	2338	c.2218T>C	c.(2218-2220)Tac>Cac	p.Y740H	MME_ENST00000492661.1_Missense_Mutation_p.Y740H|MME_ENST00000360490.2_Missense_Mutation_p.Y740H|MME_ENST00000493237.1_Missense_Mutation_p.Y740H|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000462745.1_Missense_Mutation_p.Y740H	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	740					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAGAATTCATACATGAATCC	0.428000													30	87					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182898852	182898852	+	Missense_Mutation	SNP	C	C	T	rs141913952		TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:182898852C>T	ENST00000367547.3	-	6	1348	c.1112G>A	c.(1111-1113)cGt>cAt	p.R371H	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.R252H|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	443										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TCCTTTCCTACGCCTCAGAAT	0.289000													10	25					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20516826	20516826	+	Silent	SNP	G	G	A	rs141481899	byFrequency	TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr18:20516826G>A	ENST00000399722.2	+	2	363	c.12G>A	c.(10-12)tcG>tcA	p.S4S	RBBP8_ENST00000360790.5_Silent_p.S4S|RBBP8_ENST00000327155.5_Silent_p.S4S|RBBP8_ENST00000399725.2_Silent_p.S4S	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	4				S -> L (in Ref. 1; AAC14371).	cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TGAACATCTCGGGAAGCAGCT	0.388000								Homologous recombination					22	66					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118376894	118376894	+	Silent	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr11:118376894C>T	ENST00000534358.1	+	27	10310	c.10287C>T	c.(10285-10287)atC>atT	p.I3429I	KMT2A_ENST00000354520.4_Silent_p.I3388I|KMT2A_ENST00000389506.5_Silent_p.I3426I	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CATCTAGCATCTGTGTGCTCC	0.542000													7	95					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85422147	85422147	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr1:85422147C>T	ENST00000370608.3	-	4	599	c.532G>A	c.(532-534)Gag>Aag	p.E178K	MCOLN2_ENST00000531325.1_5'UTR|MCOLN2_ENST00000284027.5_Missense_Mutation_p.E150K	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	178						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTCAGTGTCTCATTAGAAGGA	0.408000													19	112					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30975976	30975976	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr16:30975976T>A	ENST00000262519.8	+	7	1599	c.913T>A	c.(913-915)Tac>Aac	p.Y305N		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	305	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						AGAGAACAGCTACCAAGATGC	0.597000													13	77					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116963002	116963002	+	Silent	SNP	C	C	A			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr7:116963002C>A	ENST00000265441.3	-	1	341	c.42G>T	c.(40-42)ctG>ctT	p.L14L		NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	14					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AGGTCAAGAGCAGAGGGAGCC	0.622000													8	44					1.76689e-08	1.91292e-08	1	1	0
TRAPPC13	80006	broad.mit.edu	37	5	64956687	64956687	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr5:64956687delA	ENST00000399438.3	+	10	1205	c.860delA	c.(859-861)gafs	p.E287fs	TRAPPC13_ENST00000505553.1_Frame_Shift_Del_p.E281fs|TRAPPC13_ENST00000438419.2_Frame_Shift_Del_p.E287fs|TRAPPC13_ENST00000545191.1_Frame_Shift_Del_p.E288fs|TRAPPC13_ENST00000231526.4_Frame_Shift_Del_p.E281fs	NM_001093755.1|NM_024941.3	NP_001087224.1|NP_079217.2			trafficking protein particle complex 13																		AATCTAGGTGAAAGGGGAAGG	0.393													16	18	---	---	---	---					
CNBD1	168975	broad.mit.edu	37	8	88365940	88365940	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr8:88365940delA	ENST00000518476.1	+	10	1280	c.1229delA	c.(1228-1230)cafs	p.Q410fs		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	410										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						GTCCTTCTTCAAGTTCCTTTC	0.323													8	46	---	---	---	---					
GPR132	29933	broad.mit.edu	37	14	105518104	105518106	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-CQ-A4C9-01A-11D-A25D-08	TCGA-CQ-A4C9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50ae1afb-03a8-4470-8e00-5037f448bd98	fd1b9890-2f7d-455d-90f6-aa3ad1073601	g.chr14:105518104_105518106delAGA	ENST00000329797.3	-	4	1279_1281	c.368_370delTCT	c.(367-372)tgc>t	p.FC123del	GPR132_ENST00000539291.2_In_Frame_Del_p.FC123del|GPR132_ENST00000392585.2_In_Frame_Del_p.FC114del|GPR132_ENST00000546679.1_5'UTR	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	123					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		TAGATGTTGCAGAAGAAGATGTA	0.631													9	159	---	---	---	---					
