Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHM	1121	broad.mit.edu	37	X	85218989	85218989	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:85218989G>T	ENST00000357749.2	-	5	412	c.383C>A	c.(382-384)gCa>gAa	p.A128E	CHM_ENST00000467744.1_Intron|CHM_ENST00000537751.1_5'UTR	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	128					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TGTGGAGTTTGCAGATGTCAC	0.433000													20	65					2.4624e-09	2.83762e-09	1	1	0
SORCS3	22986	broad.mit.edu	37	10	106737173	106737173	+	Silent	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr10:106737173G>T	ENST00000369701.3	+	4	1103	c.876G>T	c.(874-876)cgG>cgT	p.R292R		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	292						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGAAGTATCGGCTCACCTTCT	0.448000													24	37					1.10923e-09	1.29055e-09	1	1	0
KCNQ2	3785	broad.mit.edu	37	20	62071033	62071033	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr20:62071033T>C	ENST00000354587.3	-	6	1021	c.845A>G	c.(844-846)gAc>gGc	p.D282G	KCNQ2_ENST00000344425.5_Missense_Mutation_p.D282G|KCNQ2_ENST00000370221.1_Missense_Mutation_p.D282G|KCNQ2_ENST00000370222.3_Missense_Mutation_p.D282G|KCNQ2_ENST00000357249.2_Missense_Mutation_p.D282G|KCNQ2_ENST00000359125.2_Missense_Mutation_p.D282G|KCNQ2_ENST00000370224.1_Missense_Mutation_p.D282G|KCNQ2_ENST00000344462.3_Missense_Mutation_p.D282G|KCNQ2_ENST00000370226.1_Missense_Mutation_p.D282G|KCNQ2_ENST00000359689.1_Missense_Mutation_p.D282G|KCNQ2_ENST00000360480.3_Missense_Mutation_p.D282G|KCNQ2_ENST00000430658.1_Missense_Mutation_p.D282G			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	282					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GGGGTACTTGTCCCCGTAGCC	0.642000													42	51					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80667073	80667073	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr16:80667073G>A	ENST00000299564.8	-	3	832	c.677C>T	c.(676-678)gCg>gTg	p.A226V	CDYL2_ENST00000563890.1_Missense_Mutation_p.A227V|CDYL2_ENST00000566173.1_Missense_Mutation_p.A227V|CDYL2_ENST00000562812.1_Missense_Mutation_p.A227V	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	226						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						GTCCTTCTCCGCTTCCAGCTT	0.488000													39	62					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943730	1943730	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:1943730G>T	ENST00000543818.1	+	5	1798	c.956G>T	c.(955-957)gGc>gTc	p.G319V	CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000535041.1_Missense_Mutation_p.G319V|CACNA2D4_ENST00000586184.1_Intron|LRTM2_ENST00000299194.1_Missense_Mutation_p.G319V|CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000543730.1_3'UTR	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	319						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GTCGTGTGCGGCGTCGTCTGC	0.662000													24	43					7.33628e-21	9.15144e-21	1	1	0
CAP1	10487	broad.mit.edu	37	1	40535481	40535481	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:40535481T>C	ENST00000372797.3	+	9	1489	c.928T>C	c.(928-930)Tcc>Ccc	p.S310P	CAP1_ENST00000372792.2_Missense_Mutation_p.S310P|CAP1_ENST00000479759.1_3'UTR|CAP1_ENST00000372798.1_Missense_Mutation_p.S309P|CAP1_ENST00000372802.1_Missense_Mutation_p.S309P|CAP1_ENST00000372805.3_Missense_Mutation_p.S310P|CAP1_ENST00000340450.3_Missense_Mutation_p.S309P	NM_001105530.1|NM_006367.3	NP_001099000.1|NP_006358.1	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	310					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AACCAGCCCATCCCCCAAACG	0.522000													9	46					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36363454	36363454	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:36363454A>C	ENST00000221891.4	+	7	1112	c.920A>C	c.(919-921)cAc>cCc	p.H307P	APLP1_ENST00000537454.2_Missense_Mutation_p.H268P|APLP1_ENST00000586861.1_Missense_Mutation_p.H301P	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	307					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCAGTGAGCACGAGGGGTTC	0.577000													59	122					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561627	11561627	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:11561627A>C	ENST00000294484.6	+	2	716	c.578A>C	c.(577-579)cAa>cCa	p.Q193P	PTCHD2_ENST00000389575.3_Missense_Mutation_p.Q193P	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	193					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCGCGGCTCAAAAGCCCACA	0.697000													10	11					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			59	33					0	0	1	0	0
BACH1	571	broad.mit.edu	37	21	30699670	30699670	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr21:30699670G>A	ENST00000399921.1	+	3	1768	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	BACH1_ENST00000286800.3_Missense_Mutation_p.E509K	NM_206866.1	NP_996749.1	O14867	BACH1_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 1	509						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|urinary_tract(2)	27						GACGGACACCGAAGGAGACAG	0.413000													50	90					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124157746	124157746	+	Silent	SNP	C	C	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr3:124157746C>G	ENST00000360013.3	+	18	3181	c.3054C>G	c.(3052-3054)gtC>gtG	p.V1018V	KALRN_ENST00000240874.3_Silent_p.V1018V|KALRN_ENST00000460856.1_Silent_p.V1009V	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1018					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGTGTAGTGTCCTGGAGAGCT	0.458000													10	28					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354625	41354625	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:41354625G>A	ENST00000301141.5	-	3	407	c.387C>T	c.(385-387)cgC>cgT	p.R129R	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	129					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CGATGGAGAAGCGCCGGAGCT	0.706000													23	52					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459290	141459290	+	Splice_Site	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr2:141459290C>A	ENST00000389484.3	-	40	7398	c.6427_splice	c.e40+1	p.G2143_splice		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2143	EGF-like 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGTGCTGACCTTTCTCTCTT	0.348000										TSP Lung(27;0.18)			42	21					7.63091e-17	9.32667e-17	1	1	0
GATS	352954	broad.mit.edu	37	7	99821545	99821545	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr7:99821545G>A	ENST00000436886.2	-	3	619	c.371C>T	c.(370-372)tCc>tTc	p.S124F	GATS_ENST00000543273.1_RNA	NM_178831.6	NP_849153.3	Q8NAP1	GATS_HUMAN		124										endometrium(2)|large_intestine(2)|lung(4)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CATGAACACGGATATGTTCTG	0.572000													38	81					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q|FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								28	50					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200954026	200954026	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:200954026C>T	ENST00000332129.2	-	27	4080	c.3764G>A	c.(3763-3765)cGt>cAt	p.R1255H	KIF21B_ENST00000461742.2_Missense_Mutation_p.R1255H|KIF21B_ENST00000422435.2_Missense_Mutation_p.R1255H|KIF21B_ENST00000360529.5_Missense_Mutation_p.R1255H	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1255					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ACTGGTGAGACGAGAGAAGAC	0.622000													22	24					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48234310	48234310	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr16:48234310C>A	ENST00000394747.1	-	14	2308	c.1959G>T	c.(1957-1959)caG>caT	p.Q653H	ABCC11_ENST00000353782.5_Missense_Mutation_p.Q653H|ABCC11_ENST00000356608.2_Missense_Mutation_p.Q653H|ABCC11_ENST00000394748.1_Missense_Mutation_p.Q653H|ABCC11_ENST00000537808.1_Missense_Mutation_p.Q653H	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	653	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCAGGTAGATCTGACGGTCGG	0.592000													22	31					2.54575e-18	3.14322e-18	1	1	0
KIRREL2	84063	broad.mit.edu	37	19	36350480	36350480	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:36350480G>A	ENST00000360202.5	+	5	818	c.620G>A	c.(619-621)cGg>cAg	p.R207Q	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000262625.7_Missense_Mutation_p.R207Q|KIRREL2_ENST00000592409.1_Missense_Mutation_p.R207Q|KIRREL2_ENST00000347900.6_Missense_Mutation_p.R157Q|KIRREL2_ENST00000586102.2_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	207	Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGCCGGGCCCGGAGCCAGGCC	0.627000													34	43					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678395	87678395	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr16:87678395G>A	ENST00000284262.2	+	2	1156	c.914G>A	c.(913-915)cGc>cAc	p.R305H		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	305					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GTGAGCCAGCGCTCGGACGGG	0.662000													31	57					0	0	1	0	0
HSPB2	3316	broad.mit.edu	37	11	111784181	111784181	+	Missense_Mutation	SNP	G	G	T	rs145827670	by1000genomes	TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:111784181G>T	ENST00000304298.3	+	2	699	c.111G>T	c.(109-111)gaG>gaT	p.E37D	HSPB2-C11orf52_ENST00000534100.1_Intron|CRYAB_ENST00000527950.1_Intron|HSPB2_ENST00000537382.1_Missense_Mutation_p.E37D|CRYAB_ENST00000533475.1_Intron	NM_001541.3	NP_001532.1	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	37					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			large_intestine(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		TGCCAGAAGAGATCCTGACCC	0.637000													84	257					8.2577e-42	1.08607e-41	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124832754	124832754	+	Silent	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:124832754G>T	ENST00000356219.3	-	30	4127	c.3972C>A	c.(3970-3972)cgC>cgA	p.R1324R	NCOR2_ENST00000404621.1_Silent_p.R1307R|NCOR2_ENST00000404121.2_Silent_p.R878R|NCOR2_ENST00000429285.2_Silent_p.R1307R|NCOR2_ENST00000397355.1_Silent_p.R1308R|NCOR2_ENST00000405201.1_Silent_p.R1317R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1325					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTCTGCCCACGCGGCCCTCCA	0.652000											OREG0022238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	46					1.66031e-10	1.96958e-10	1	1	0
CR2	1380	broad.mit.edu	37	1	207649600	207649600	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:207649600C>T	ENST00000367057.3	+	15	2927	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	CR2_ENST00000367059.3_Intron|CR2_ENST00000367058.3_Missense_Mutation_p.P854L|CR2_ENST00000458541.2_Missense_Mutation_p.P827L	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	854	Sushi 15.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGTCCACCTCCGCCTAAGACC	0.493000													16	50					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10428261	10428261	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:10428261G>T	ENST00000293677.6	-	13	2221	c.2140C>A	c.(2140-2142)Cag>Aag	p.Q714K	CTD-2369P2.12_ENST00000586529.1_Missense_Mutation_p.Q115K	NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	0						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CTGCGTTTCTGGCCGCCCAGT	0.741000													15	18					7.93312e-07	8.80649e-07	1	1	0
ATP7B	540	broad.mit.edu	37	13	52524492	52524492	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr13:52524492C>T	ENST00000242839.4	-	10	2647	c.2491G>A	c.(2491-2493)Gtc>Atc	p.V831I	ATP7B_ENST00000448424.2_Missense_Mutation_p.V753I|ATP7B_ENST00000344297.5_Missense_Mutation_p.V669I|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000417240.2_Missense_Mutation_p.V103I|ATP7B_ENST00000418097.2_Missense_Mutation_p.V831I|ATP7B_ENST00000400366.3_Missense_Mutation_p.V720I	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	831					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ACCACCTTGACGATATCGCCC	0.557000									Wilson disease				11	33					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7330538	7330538	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:7330538G>C	ENST00000333870.3	+	3	1302	c.1228G>C	c.(1228-1230)Gcc>Ccc	p.A410P	C17orf74_ENST00000574034.1_3'UTR|RP11-104H15.7_ENST00000575310.1_RNA	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	410						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				GTTGGACGAGGCCTCCCATCA	0.697000													13	33					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117676917	117676917	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:117676917C>T	ENST00000276204.6	+	3	322	c.248C>T	c.(247-249)aCg>aTg	p.T83M	DOCK11_ENST00000276202.7_Missense_Mutation_p.T83M			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	83	Interaction with activated CDC42 (By similarity).				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CAACGCAGAACGGTGCAGTCT	0.398000													18	64					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58253014	58253014	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr15:58253014G>T	ENST00000249750.4	-	12	2205	c.1438C>A	c.(1438-1440)Cag>Aag	p.Q480K	ALDH1A2_ENST00000559517.1_Missense_Mutation_p.Q384K|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.Q459K|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.Q442K|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.Q451K	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	480					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	AAGGGGCTCTGGGCATTTAAG	0.418000													21	29					3.62473e-10	4.25818e-10	1	1	0
TAPT1-AS1	202020	broad.mit.edu	37	4	16258163	16258163	+	RNA	SNP	C	C	T	rs10027456	by1000genomes	TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr4:16258163C>T	ENST00000570786.1	+	0	518				TAPT1-AS1_ENST00000573950.1_RNA|TAPT1-AS1_ENST00000573308.1_RNA	NR_027696.1																						ACGAACTCGCCGGCGTTGTTC	0.607000													3	23					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88047695	88047695	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr5:88047695G>A	ENST00000504921.2	-	5	1240	c.568C>T	c.(568-570)Cct>Tct	p.P190S	MEF2C_ENST00000437473.2_Missense_Mutation_p.P190S|MEF2C_ENST00000514015.1_Missense_Mutation_p.P190S|MEF2C_ENST00000424173.2_Missense_Mutation_p.P188S|MEF2C_ENST00000514028.1_Missense_Mutation_p.P190S|MEF2C_ENST00000503554.1_5'UTR|MEF2C_ENST00000508569.1_Missense_Mutation_p.P190S|MEF2C_ENST00000340208.5_Missense_Mutation_p.P208S|MEF2C_ENST00000506554.1_Missense_Mutation_p.P190S|MEF2C_ENST00000510942.1_Missense_Mutation_p.P190S|MEF2C_ENST00000539796.1_Missense_Mutation_p.P142S			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	190					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GCACTTGGAGGTCGATGTGTT	0.473000										HNSCC(66;0.2)			56	130					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109948218	109948218	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:109948218G>A	ENST00000342494.3	+	17	2406	c.1811G>A	c.(1810-1812)cGg>cAg	p.R604Q	UBE3B_ENST00000434735.2_Missense_Mutation_p.R604Q|UBE3B_ENST00000535900.1_3'UTR|UBE3B_ENST00000280774.5_Missense_Mutation_p.R604Q	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	604					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CTGTACGAGCGGGACTGCCGG	0.627000													5	12					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1780781	1780781	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:1780781G>A	ENST00000236671.2	-	3	449	c.317C>T	c.(316-318)cCc>cTc	p.P106L		NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	106					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTGGATGGAGGGGACCCACAG	0.657000													28	102					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18775082	18775082	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:18775082A>G	ENST00000300976.4	+	2	185	c.95A>G	c.(94-96)aAg>aGg	p.K32R	KLHL26_ENST00000596843.1_3'UTR|KLHL26_ENST00000595182.1_Missense_Mutation_p.K32R|KLHL26_ENST00000599006.1_Missense_Mutation_p.K32R	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	32										breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						ACGGCCGACAAGAACGGGGCC	0.622000													46	118					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32509576	32509576	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:32509576C>T	ENST00000357033.4	-	20	2646	c.2440G>A	c.(2440-2442)Gaa>Aaa	p.E814K	DMD_ENST00000378677.2_Missense_Mutation_p.E810K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	814					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGGCAGAATTCGATCCACCGG	0.408000													19	43					0	0	1	0	0
SLC16A1	6566	broad.mit.edu	37	1	113459887	113459887	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:113459887G>A	ENST00000538576.1	-	4	1972	c.1141C>T	c.(1141-1143)Ctt>Ttt	p.L381F	SLC16A1_ENST00000433570.4_Missense_Mutation_p.L381F|SLC16A1_ENST00000369626.3_Missense_Mutation_p.L381F	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	381					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	GGTCCAACAAGGTCCATCAAT	0.488000													15	28					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88752206	88752206	+	RNA	SNP	G	G	A	rs1745903	by1000genomes	TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr10:88752206G>A	ENST00000444431.1	+	0	44				RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CTGCTGTGGGGATGGCTTGAT	0.423000													3	26					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54726840	54726840	+	Silent	SNP	G	G	A	rs144205480	byFrequency	TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:54726840G>A	ENST00000391750.1	-	2	145	c.9C>T	c.(7-9)ccC>ccT	p.P3P	LILRA6_ENST00000391735.3_Intron|LILRB3_ENST00000245620.9_Silent_p.P3P|LILRA6_ENST00000270464.5_Intron|LILRB3_ENST00000346401.6_Silent_p.P3P|LILRA6_ENST00000440558.2_Intron|LILRB3_ENST00000407860.2_Intron|LILRB3_ENST00000424807.1_Silent_p.P3P|LILRA6_ENST00000419410.2_Intron			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	3					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGTGAGGGCGGGCGTCATGG	0.642000													12	64					0	0	1	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69420163	69420163	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:69420163A>C	ENST00000333026.3	+	4	426	c.326A>C	c.(325-327)cAt>cCt	p.H109P		NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	109					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						AATCACCCCCATGGCATTCTC	0.463000													27	54					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4836597	4836597	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:4836597G>A	ENST00000329125.5	+	2	773	c.698G>A	c.(697-699)cGt>cAt	p.R233H		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	233										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						CTCTATTTTCGTCGCTGGCTG	0.498000													28	54					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105924557	105924557	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:105924557C>A	ENST00000526793.1	-	3	1018	c.859G>T	c.(859-861)Gat>Tat	p.D287Y	KBTBD3_ENST00000531837.1_Missense_Mutation_p.D287Y|KBTBD3_ENST00000534815.1_Missense_Mutation_p.D208Y	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	283										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		GGTCGAGCATCAGGGAAGAGT	0.358000													73	78					1.356e-25	1.72712e-25	1	1	0
TBL1X	6907	broad.mit.edu	37	X	9659730	9659730	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:9659730T>G	ENST00000217964.7	+	8	1368	c.728T>G	c.(727-729)gTc>gGc	p.V243G	TBL1X_ENST00000380961.1_Missense_Mutation_p.V192G|TBL1X_ENST00000424279.1_Missense_Mutation_p.V192G|TBL1X_ENST00000536365.1_Missense_Mutation_p.V192G|TBL1X_ENST00000407597.2_Missense_Mutation_p.V243G	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	243					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				TGGAATCCTGTCAGTGATTTG	0.547000													25	46					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49840630	49840630	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:49840630C>A	ENST00000376088.3	+	7	1237	c.596C>A	c.(595-597)aCa>aAa	p.T199K	CLCN5_ENST00000376108.3_Missense_Mutation_p.T129K|CLCN5_ENST00000307367.2_Missense_Mutation_p.T129K|CLCN5_ENST00000376091.3_Missense_Mutation_p.T199K	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	129					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					ATCATCAGCACAGATGAGGTA	0.388000													22	55					8.10497e-08	9.2519e-08	1	1	0
SEC11C	90701	broad.mit.edu	37	18	56816786	56816786	+	Silent	SNP	T	T	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr18:56816786T>C	ENST00000587834.1	+	2	601	c.129T>C	c.(127-129)tcT>tcC	p.S43S	SEC11C_ENST00000588875.1_Silent_p.S43S	NM_033280.2	NP_150596.1	Q9BY50	SC11C_HUMAN	SEC11 homolog C (S. cerevisiae)	43					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity			endometrium(1)|large_intestine(4)|liver(2)|lung(2)	9		Colorectal(73;0.175)				TCGTGTCTTCTGCACTCATGA	0.507000													5	65					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42174866	42174866	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr15:42174866G>A	ENST00000320955.6	-	10	2190	c.1963C>T	c.(1963-1965)Ctg>Ttg	p.L655L		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	655					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CACTCCTTCAGCCAGGCTTCC	0.667000													6	10					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	16000015	16000015	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr4:16000015C>A	ENST00000505450.1	-	14	2260	c.1648G>T	c.(1648-1650)Gtt>Ttt	p.V550F	PROM1_ENST00000540805.1_Missense_Mutation_p.V559F|PROM1_ENST00000508167.1_Missense_Mutation_p.V550F|PROM1_ENST00000543373.1_Missense_Mutation_p.V550F|PROM1_ENST00000539194.1_Missense_Mutation_p.V559F|PROM1_ENST00000447510.2_Missense_Mutation_p.V559F|PROM1_ENST00000510224.1_Missense_Mutation_p.V559F	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	559					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						TACCTGTAAACTTGTTCAAAA	0.294000													7	13					0.000157383	0.00017003	1	1	0
ST6GALNAC2	10610	broad.mit.edu	37	17	74569351	74569351	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:74569351G>A	ENST00000225276.5	-	4	775	c.456C>T	c.(454-456)gcC>gcT	p.A152A	ST6GALNAC2_ENST00000586520.1_5'UTR	NM_006456.2	NP_006447.2	Q9UJ37	SIA7B_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	152					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	11						TGCCCACCACGGCACACCGGA	0.607000													6	9					0	0	1	0	0
AKAP14	158798	broad.mit.edu	37	X	119037536	119037536	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:119037536A>C	ENST00000371431.3	+	4	522	c.248A>C	c.(247-249)gAc>gCc	p.D83A	AKAP14_ENST00000371423.2_Missense_Mutation_p.D83A|AKAP14_ENST00000334356.2_Missense_Mutation_p.D83A|AKAP14_ENST00000371425.4_Missense_Mutation_p.D83A|AKAP14_ENST00000394594.2_Missense_Mutation_p.D83A|AKAP14_ENST00000371422.1_Missense_Mutation_p.D83A	NM_178813.5	NP_848928.1	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14	83						cytoplasm				endometrium(4)|large_intestine(1)|lung(8)	13						AAACAAATTGACGAATATTTT	0.418000													21	43					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1465950	1465950	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:1465950C>T	ENST00000535453.1	+	14	4363	c.2650C>T	c.(2650-2652)Cca>Tca	p.P884S	APC2_ENST00000238483.4_Missense_Mutation_p.P610S|C19orf25_ENST00000588427.1_Intron|APC2_ENST00000233607.2_Missense_Mutation_p.P884S			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	884					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGAGGCGCCACGGGAGGG	0.731000													6	8					0	0	1	0	0
SLC7A1	6541	broad.mit.edu	37	13	30110113	30110113	+	Silent	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr13:30110113C>A	ENST00000380752.5	-	3	599	c.213G>T	c.(211-213)ctG>ctT	p.L71L		NM_003045.4	NP_003036.1	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	71					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|stomach(1)|urinary_tract(2)	24		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GCGCAGCGATCAGGAAGGAGA	0.632000													13	40					0.00244969	0.00257751	1	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125285025	125285025	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr2:125285025C>G	ENST00000431078.1	+	10	2002	c.1638C>G	c.(1636-1638)atC>atG	p.I546M		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	546	EGF-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGTGTAGCATCAAAGACAGGT	0.403000													22	57					0	0	1	0	0
FCGR1B	2210	broad.mit.edu	37	1	120930249	120930249	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:120930249C>T	ENST00000369384.4	-	4	394	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K	RP11-439A17.10_ENST00000426275.1_RNA|FCGR1B_ENST00000472543.1_5'UTR|RP11-439A17.9_ENST00000457996.1_RNA|FCGR1B_ENST00000369383.4_Missense_Mutation_p.E26K	NM_001017986.3	NP_001017986.1	Q92637	FCGRB_HUMAN	Fc fragment of IgG, high affinity Ib, receptor (CD64)	118	Ig-like C2-type 2.				interferon-gamma-mediated signaling pathway	integral to membrane|plasma membrane	IgG binding|immunoglobulin receptor activity			breast(1)|endometrium(1)|lung(2)	4	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		GCCAGAGGTTCTCCTTCCATG	0.463000													45	114					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81706258	81706258	+	Missense_Mutation	SNP	C	C	T	rs142564545		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr10:81706258C>T	ENST00000372292.3	-	2	198	c.158G>A	c.(157-159)cGg>cAg	p.R53Q		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	53	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCTCCCATCCCGTCCATCGCG	0.597000													25	47					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022217	34022217	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr20:34022217G>A	ENST00000374372.1	-	4	1499	c.996C>T	c.(994-996)gcC>gcT	p.A332A	GDF5OS_ENST00000374375.1_Silent_p.A87A|GDF5_ENST00000374369.3_Silent_p.A332A			P43026	GDF5_HUMAN	growth differentiation factor 5	332					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CCTGCCGGGCGGCGCGGTCGA	0.637000													36	89					0	0	1	0	0
EVA1C	59271	broad.mit.edu	37	21	33830008	33830008	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr21:33830008T>G	ENST00000300255.2	+	3	934	c.461T>G	c.(460-462)gTc>gGc	p.V154G	EVA1C_ENST00000401402.3_Missense_Mutation_p.V154G|EVA1C_ENST00000382699.3_Missense_Mutation_p.V154G	NM_058187.3	NP_478067.2			eva-1 homolog C (C. elegans)																		TACCTCCTGGTCTCCTTTAAA	0.522000													20	46					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22680762	22680762	+	Silent	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr10:22680762C>T	ENST00000376603.2	+	8	1480	c.1338C>T	c.(1336-1338)caC>caT	p.H446H	RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376601.1_Silent_p.H131H|SPAG6_ENST00000490361.1_3'UTR|SPAG6_ENST00000376624.3_Silent_p.H370H|SPAG6_ENST00000313311.6_Silent_p.H370H|SPAG6_ENST00000538630.1_Silent_p.H345H			O75602	SPAG6_HUMAN	sperm associated antigen 6	370					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						CTCCTGAACACGCACGGGCTG	0.453000													16	34					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164780178	164780178	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr3:164780178A>G	ENST00000264382.3	-	9	1063	c.1001T>C	c.(1000-1002)gTa>gCa	p.V334A		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	334	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTGTTGAACTACTTGTTCTGG	0.333000										HNSCC(35;0.089)			18	63					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149515170	149515170	+	RNA	SNP	C	C	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr7:149515170C>G	ENST00000378016.2	+	0	11560							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGCCGTGGGCCCCGCCAGGA	0.697000													5	10					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203044811	203044811	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:203044811C>T	ENST00000367240.2	+	28	3964	c.3437C>T	c.(3436-3438)cCg>cTg	p.P1146L	PPFIA4_ENST00000414050.2_Missense_Mutation_p.P874L|PPFIA4_ENST00000295706.4_Missense_Mutation_p.P652L|PPFIA4_ENST00000599966.1_Missense_Mutation_p.P652L|PPFIA4_ENST00000272198.6_Missense_Mutation_p.P661L|PPFIA4_ENST00000447715.2_Missense_Mutation_p.P1145L			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	661					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GAGACCCTCCCGGCGGGCTTC	0.706000													6	9					0	0	1	0	0
ZNF449	203523	broad.mit.edu	37	X	134483099	134483099	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:134483099C>A	ENST00000339249.4	+	3	559	c.419C>A	c.(418-420)aCc>aAc	p.T140N		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	140					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ATACCACCAACCATGCACCTA	0.567000													64	150					5.5144e-22	6.95045e-22	1	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098975	178098975	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr2:178098975A>G	ENST00000397062.3	-	2	624	c.70T>C	c.(70-72)Tgg>Cgg	p.W24R	NFE2L2_ENST00000446151.2_Missense_Mutation_p.W8R|NFE2L2_ENST00000397063.4_Missense_Mutation_p.W8R|NFE2L2_ENST00000423513.1_Missense_Mutation_p.W8R|NFE2L2_ENST00000464747.1_Missense_Mutation_p.W8R	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.W24R(2)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCTTGCCTCCAAAGTATGTCA	0.348000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			38	12					0	0	1	0	0
WIPF2	147179	broad.mit.edu	37	17	38412764	38412764	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:38412764C>T	ENST00000323571.4	+	2	293	c.53C>T	c.(52-54)aCa>aTa	p.T18I	WIPF2_ENST00000585043.1_Missense_Mutation_p.T18I|WIPF2_ENST00000494757.1_Intron|WIPF2_ENST00000536600.1_Missense_Mutation_p.T18I|WIPF2_ENST00000394103.3_Missense_Mutation_p.T18I|WIPF2_ENST00000583130.1_Missense_Mutation_p.T18I	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	18						cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						CCACCTCCCACATTTCATCAG	0.468000										HNSCC(43;0.11)			33	57					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10385558	10385558	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:10385558C>T	ENST00000264832.3	+	2	510	c.185C>T	c.(184-186)aCc>aTc	p.T62I	ICAM1_ENST00000423829.2_Intron|CTD-2369P2.5_ENST00000592893.1_RNA	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	62	Ig-like C2-type 1.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GGCATAGAGACCCCGTTGCCT	0.537000													42	86					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533552	533552	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:533552C>A	ENST00000417302.1	-	4	538	c.351G>T	c.(349-351)aaG>aaT	p.K117N	HRAS_ENST00000397594.1_Missense_Mutation_p.K117N|HRAS_ENST00000451590.1_Missense_Mutation_p.K117N|HRAS_ENST00000397596.2_Missense_Mutation_p.K117N|HRAS_ENST00000311189.7_Missense_Mutation_p.K117N	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	117			K -> R (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.K117N(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCAGGTCACACTTGTTCCCCA	0.632000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			74	127					1.15074e-40	1.4972e-40	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113275944	113275944	+	Silent	SNP	G	G	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr8:113275944G>C	ENST00000297405.5	-	61	10030	c.9786C>G	c.(9784-9786)ggC>ggG	p.G3262G	CSMD3_ENST00000455883.2_Silent_p.G3093G|CSMD3_ENST00000352409.3_Silent_p.G3192G|CSMD3_ENST00000343508.3_Silent_p.G3222G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3262	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATAGCTCATAGCCTGGAGAAC	0.473000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	60					0	0	1	0	0
ZNF420	147923	broad.mit.edu	37	19	37618388	37618388	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:37618388A>C	ENST00000337995.3	+	5	710	c.495A>C	c.(493-495)aaA>aaC	p.K165N	ZNF585A_ENST00000588723.1_Intron|ZNF420_ENST00000304239.7_Missense_Mutation_p.K165N	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGGTGAAAAACCCTATGAAT	0.423000													28	54					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810742	123810742	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:123810742T>A	ENST00000307033.2	+	1	493	c.419T>A	c.(418-420)gTc>gAc	p.V140D		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AATCAGACTGTCTGTGCACTC	0.522000													21	106					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15308354	15308354	+	Nonsense_Mutation	SNP	C	C	A	rs148166997		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:15308354C>A	ENST00000263388.2	-	2	229	c.154G>T	c.(154-156)Gga>Tga	p.G52*		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	52	EGF-like 1.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAACGACCTCCATTTGCACAC	0.687000													6	7					0.0215528	0.0222896	1	1	0
RPL12P38	645688	broad.mit.edu	37	17	58512431	58512431	+	RNA	SNP	T	T	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:58512431T>A	ENST00000588627.1	-	0	926																											AAAAAAAAAGTAAAATAAAAT	0.323000													5	17					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19576921	19576921	+	Splice_Site	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr9:19576921C>T	ENST00000341998.2	-	5	1290		c.e5+1		SLC24A2_ENST00000286344.3_Splice_Site	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2						visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		CCTGCACTCACCCACGTGGTT	0.557000													22	30					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47364534	47364534	+	RNA	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:47364534C>A	ENST00000505841.1	-	0	302					NR_002788.2																						TCAGGAGAATCTTGACATAGT	0.478000													19	46					5.3912e-06	5.93032e-06	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52417474	52417474	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr3:52417474G>A	ENST00000420323.2	+	51	8275	c.8014G>A	c.(8014-8016)Gcg>Acg	p.A2672T		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2672	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTGTATACTGCGGACGAGCA	0.557000													13	25					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730375	96730375	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr14:96730375C>G	ENST00000216629.6	+	3	962	c.356C>G	c.(355-357)gCc>gGc	p.A119G	RP11-404P21.3_ENST00000553638.1_RNA|BDKRB1_ENST00000553356.1_Missense_Mutation_p.A119G	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	119					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		GTCATCAAGGCCAATTTGTTC	0.592000													28	118					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466706	56466706	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:56466706G>A	ENST00000291971.3	+	3	1353	c.1282G>A	c.(1282-1284)Gtc>Atc	p.V428I	NLRP8_ENST00000590542.1_Missense_Mutation_p.V428I	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	428	NACHT.					cytoplasm	ATP binding	p.V428I(1)		breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTCTGTGTTCGTCCGGTATAT	0.498000													45	65					0	0	1	0	0
KCTD12	115207	broad.mit.edu	37	13	77459494	77459494	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr13:77459494C>T	ENST00000377474.2	-	1	1031	c.790G>A	c.(790-792)Gag>Aag	p.E264K	KCTD12_ENST00000317765.2_Missense_Mutation_p.E264K	NM_138444.3	NP_612453.1	Q96CX2	KCD12_HUMAN	potassium channel tetramerization domain containing 12	264						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		GTGTAGCGCTCCGGGGGACGG	0.637000											OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	20					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663566	169663566	+	RNA	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr3:169663566C>T	ENST00000483289.2	-	0	3728				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						TACTGTAAAACGGGAGAAAAG	0.413000													10	31					0	0	1	0	0
GJC1	10052	broad.mit.edu	37	17	42882006	42882006	+	Missense_Mutation	SNP	C	C	T	rs146820007		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:42882006C>T	ENST00000426548.1	-	3	1449	c.1180G>A	c.(1180-1182)Gtc>Atc	p.V394I	GJC1_ENST00000590758.1_Missense_Mutation_p.V394I|GJC1_ENST00000330514.4_Missense_Mutation_p.V394I|GJC1_ENST00000592524.1_Missense_Mutation_p.V394I	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	394					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				TAAATCCAGACGGAGGTCTTC	0.488000													36	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595332	82595332	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr7:82595332C>T	ENST00000423517.2	-	4	4109	c.3772G>A	c.(3772-3774)Gaa>Aaa	p.E1258K	PCLO_ENST00000333891.8_Missense_Mutation_p.E1258K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1197					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTCTGTTCTTCTGGGGCTGAT	0.413000													71	151					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103947745	103947745	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr4:103947745C>A	ENST00000394785.3	-	12	2027	c.1396G>T	c.(1396-1398)Gca>Tca	p.A466S	SLC9B2_ENST00000339611.4_Intron|SLC9B2_ENST00000503103.1_Missense_Mutation_p.C363F|SLC9B2_ENST00000362026.3_Missense_Mutation_p.A466S|SLC9B2_ENST00000503230.1_Missense_Mutation_p.A409S	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	466					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										GATCCTATTGCAGCCTATAAA	0.353000													30	48					3.65163e-15	4.41847e-15	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33337511	33337511	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr20:33337511G>A	ENST00000374796.2	-	10	5057	c.2487C>T	c.(2485-2487)gtC>gtT	p.V829V	NCOA6_ENST00000359003.2_Silent_p.V829V			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	829	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|NCOA6IP-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CATGAGGGGGGACCATGTTGG	0.502000													133	116					0	0	1	0	0
SYCN	342898	broad.mit.edu	37	19	39694790	39694790	+	Silent	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:39694790C>T	ENST00000318438.6	-	1	116	c.105G>A	c.(103-105)acG>acA	p.T35T		NM_001080468.2	NP_001073937.1	Q0VAF6	SYCN_HUMAN	syncollin	35					exocytosis	transport vesicle membrane				endometrium(1)|kidney(1)	2	all_cancers(60;7.32e-07)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|all_epithelial(25;8.97e-07)|Ovarian(47;0.0454)		Epithelial(26;1.34e-25)|all cancers(26;9.31e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGCAAGTGCGCGTCCCGTCCG	0.716000													18	27					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42360793	42360793	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr14:42360793G>C	ENST00000298119.4	+	4	2915	c.1726G>C	c.(1726-1728)Gct>Cct	p.A576P	LRFN5_ENST00000554120.1_Intron|LRFN5_ENST00000554171.1_Intron	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	576						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AACTAACGGGGCTCAAATACA	0.453000										HNSCC(30;0.082)			19	100					0	0	1	0	0
WFIKKN1	117166	broad.mit.edu	37	16	682656	682656	+	Silent	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr16:682656C>A	ENST00000319070.2	+	2	568	c.246C>A	c.(244-246)ggC>ggA	p.G82G		NM_053284.2	NP_444514.1	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	82						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|prostate(1)|upper_aerodigestive_tract(1)	4		Hepatocellular(780;0.00335)				GCTTCCCCGGCAGCCCAGCTG	0.677000													7	17					8.12818e-05	8.86045e-05	1	1	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342186	60342186	+	RNA	SNP	T	T	C	rs79096325		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:60342186T>C	ENST00000581291.1	-	0	1967																				breast(2)|kidney(1)|lung(2)	5						GCTGGGGGTGTTGGGAGGGGC	0.498000													3	22					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895068	77895068	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr18:77895068C>A	ENST00000262198.4	+	4	2227	c.1772C>A	c.(1771-1773)aCc>aAc	p.T591N		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	591					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CAGAACACCACCTTCCTGACA	0.552000													22	16					5.26018e-13	6.3018e-13	1	1	0
TMTC2	160335	broad.mit.edu	37	12	83289634	83289634	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:83289634T>A	ENST00000549919.1	+	4	2479	c.674T>A	c.(673-675)tTa>tAa	p.L225*	TMTC2_ENST00000321196.3_Nonsense_Mutation_p.L231*|TMTC2_ENST00000548305.1_Nonsense_Mutation_p.L231*			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	231						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						ATTAGTTTGTTAATTTTCTGG	0.433000													48	73					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56528147	56528147	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:56528147C>T	ENST00000394048.5	+	15	1831	c.1567C>T	c.(1567-1569)Cca>Tca	p.P523S	ESYT1_ENST00000267113.4_Missense_Mutation_p.P533S|ESYT1_ENST00000541590.1_Missense_Mutation_p.P533S	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	523	C2 2.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						TACCAACTGCCCAGTGTGGGA	0.512000													34	78					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953521	56953521	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:56953521A>C	ENST00000504904.3	-	7	1562	c.843T>G	c.(841-843)caT>caG	p.H281Q	ZNF667_ENST00000342634.3_Missense_Mutation_p.H409Q|ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000292069.6_Missense_Mutation_p.H281Q			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TATTATATTTATGTGTTTTCT	0.368000													39	95					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506882	11506882	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr12:11506882G>T	ENST00000500254.2	-	3	192	c.155C>A	c.(154-156)cCt>cAt	p.P52H	PRB1_ENST00000546254.1_Missense_Mutation_p.P52H|PRB1_ENST00000545626.1_Missense_Mutation_p.P52H	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	235						extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TCCTGGAGGAGGTGGGGGGCC	0.582000													74	149					5.2429e-30	6.74884e-30	1	1	0
CTH	1491	broad.mit.edu	37	1	70887340	70887340	+	Silent	SNP	A	A	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:70887340A>G	ENST00000411986.2	+	3	540	c.342A>G	c.(340-342)gcA>gcG	p.A114A	CTH_ENST00000370938.3_Silent_p.A146A|CTH_ENST00000464926.1_3'UTR|CTH_ENST00000346806.2_Silent_p.A146A	NM_001190463.1	NP_001177392.1	P32929	CGL_HUMAN	cystathionase (cystathionine gamma-lyase)	146					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TAGAGGCAGCAATTACACCAG	0.353000													12	36					0	0	1	0	0
RRP1	8568	broad.mit.edu	37	21	45217866	45217866	+	Silent	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr21:45217866C>T	ENST00000497547.1	+	8	813	c.696C>T	c.(694-696)ctC>ctT	p.L232L	RRP1_ENST00000471909.1_3'UTR	NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	232					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		TTGAAGACCTCCTGAATGAAC	0.572000													19	32					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203012543	203012543	+	Silent	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr1:203012543C>A	ENST00000367240.2	+	3	780	c.253C>A	c.(253-255)Cgg>Agg	p.R85R	PPFIA4_ENST00000295706.4_5'UTR|PPFIA4_ENST00000447715.2_Silent_p.R85R			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CACCTTAACCCGGGAGCTGAG	0.542000													3	4					0.115264	0.117201	1	1	0
FAM126A	84668	broad.mit.edu	37	7	22985394	22985394	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr7:22985394G>A	ENST00000432176.2	-	11	1612	c.1380C>T	c.(1378-1380)gtC>gtT	p.V460V	FAM126A_ENST00000409923.1_3'UTR	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	460						cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						GTGGGACTGTGACACCACTGA	0.468000													32	76					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67102347	67102347	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr17:67102347C>A	ENST00000284425.2	-	19	2569	c.2395G>T	c.(2395-2397)Gaa>Taa	p.E799*		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	799					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TCCACTTGTTCGAAATCTATA	0.378000													10	30					7.48243e-07	8.38309e-07	1	1	0
PAMR1	25891	broad.mit.edu	37	11	35454063	35454063	+	Silent	SNP	G	G	A			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr11:35454063G>A	ENST00000378880.2	-	11	2449	c.2004C>T	c.(2002-2004)atC>atT	p.I668I	PAMR1_ENST00000378878.3_Silent_p.I557I|PAMR1_ENST00000532848.1_Silent_p.I628I|PAMR1_ENST00000278360.3_Silent_p.I685I	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	668	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						ACACAGCCGCGATGCCTCCTG	0.567000													32	94					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113935464	113935464	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr10:113935464C>T	ENST00000348367.4	-	6	504	c.307G>A	c.(307-309)Gga>Aga	p.G103R	GPAM_ENST00000369425.1_Missense_Mutation_p.G103R|GPAM_ENST00000423155.1_Missense_Mutation_p.G103R			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	103					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity	p.G103*(1)		breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		GCAAGCCATCCGCGGTGTCTG	0.408000													14	49					0	0	1	0	0
LINC01250	101927554	broad.mit.edu	37	2	2910724	2910724	+	RNA	DEL	C	C	-			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr2:2910724delC	ENST00000457478.1	-	0	594																											caccccctctccccagcccac	0.706													2	4	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187628153	187628154	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr4:187628153_187628154insC	ENST00000441802.2	-	2	3037_3038	c.2828_2829insG	c.(2827-2829)gacfs	p.D943fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	943	Cadherin 8.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TGATGACGGTTCCTTCTGGAAG	0.455										HNSCC(5;0.00058)			93	147	---	---	---	---					
ZBTB22	9278	broad.mit.edu	37	6	33283037	33283037	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr6:33283037delG	ENST00000431845.2	-	2	1808	c.1657delC	c.(1657-1659)gafs	p.R553fs	ZBTB22_ENST00000418724.1_Frame_Shift_Del_p.R553fs	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						AAGCTGTCTCGCCACATGAAC	0.617													56	90	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75145720	75145721	+	RNA	DEL	AT	AT	-			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr7:75145720_75145721delAT	ENST00000418756.1	-	0	618					NR_028059.1															lung(1)	1						TCCTTTGGGGatatatatatat	0.302													3	6	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130486240	130486241	+	RNA	INS	-	-	GCTTAACATG	rs146923907	by1000genomes	TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr8:130486240_130486241insGCTTAACATG	ENST00000446592.3	-	0	360																											ggctcagctcagcttaacatgg	0.545													5	1	---	---	---	---					
CEACAM20	125931	broad.mit.edu	37	19	45017502	45017503	+	RNA	DEL	GC	GC	-	rs10669399		TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr19:45017502_45017503delGC	ENST00000454753.1	-	0	1588							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ttttggttttgctttttttttt	0.460													2	4	---	---	---	---					
AIFM3	150209	broad.mit.edu	37	22	21328069	21328070	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chr22:21328069_21328070insG	ENST00000399167.2	+	4	508_509	c.268_269insG	c.(268-270)gggfs	p.G90fs	AIFM3_ENST00000440238.2_Frame_Shift_Ins_p.G90fs|AIFM3_ENST00000399163.2_Frame_Shift_Ins_p.G90fs|AIFM3_ENST00000333607.6_Frame_Shift_Ins_p.G90fs|AIFM3_ENST00000335375.5_Intron|AIFM3_ENST00000405089.1_Frame_Shift_Ins_p.G96fs	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGAGCTGGGCTGGGGGAAGGTG	0.629													2	4	---	---	---	---					
DGAT2L6	347516	broad.mit.edu	37	X	69420157	69420158	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CQ-A4CG-01A-11D-A25Y-08	TCGA-CQ-A4CG-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	009cbff6-7773-4ad9-a8a3-4770af607598	08cf1852-84bf-4af9-b7ea-12d38a3749fb	g.chrX:69420157_69420158insC	ENST00000333026.3	+	4	420_421	c.320_321insC	c.(319-321)cccfs	p.P107fs		NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	107					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						ATTGCCAATCACCCCCATGGCA	0.465													22	67	---	---	---	---					
