Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MROH2B	133558	broad.mit.edu	37	5	41047840	41047840	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:41047840C>A	ENST00000399564.4	-	17	2161	c.1711G>T	c.(1711-1713)Gaa>Taa	p.E571*	MROH2B_ENST00000506092.2_Nonsense_Mutation_p.E126*	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AGCATGGTTTCCCATAGAACG	0.383000													6	7					0.0293803	0.0297499	1	1	0
CACNA1S	779	broad.mit.edu	37	1	201047050	201047050	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:201047050C>T	ENST00000362061.3	-	11	1802	c.1576G>A	c.(1576-1578)Gtg>Atg	p.V526M	CACNA1S_ENST00000367338.3_Missense_Mutation_p.V526M	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	526					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAGCGGAGCACGGAGATGCCC	0.632000													27	48					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66197808	66197808	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:66197808G>A	ENST00000273854.3	-	17	3491	c.2891C>T	c.(2890-2892)tCt>tTt	p.S964F	EPHA5_ENST00000354839.4_Missense_Mutation_p.S942F|EPHA5_ENST00000511294.1_Missense_Mutation_p.S965F|EPHA5_ENST00000432638.2_Missense_Mutation_p.S801F	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	964					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.S964Y(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GTAGGCCCCAGATCCTAGTGG	0.358000										TSP Lung(17;0.13)			31	17					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101300145	101300145	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:101300145G>A	ENST00000519449.1	-	3	574	c.258C>T	c.(256-258)ggC>ggT	p.G86G	RNF19A_ENST00000341084.2_Silent_p.G86G	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	86					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CATCCACCCCGCCATTTAGCT	0.373000													70	137					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111701419	111701419	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:111701419T>C	ENST00000435970.1	-	13	1802	c.986A>G	c.(985-987)gAc>gGc	p.D329G	REV3L_ENST00000368802.3_Missense_Mutation_p.D407G|REV3L_ENST00000358835.3_Missense_Mutation_p.D407G|REV3L_ENST00000368805.1_Missense_Mutation_p.D407G			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	407					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGGACTACTGTCCACTATAAA	0.433000								DNA polymerases (catalytic subunits)					47	70					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527778	23527778	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:23527778G>A	ENST00000296682.3	+	11	2763	c.2581G>A	c.(2581-2583)Gtc>Atc	p.V861I		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	861					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GAAGCCCTACGTCTGCAGGGA	0.592000										HNSCC(3;0.000094)			54	103					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039233	11039233	+	RNA	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr21:11039233C>A	ENST00000470054.1	-	0	970									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTTGGATACCACTGTTTTAG	0.403000													33	241					1.30897e-18	1.52713e-18	1	1	0
WNK3	65267	broad.mit.edu	37	X	54259280	54259280	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:54259280T>A	ENST00000354646.2	-	21	5240	c.4802A>T	c.(4801-4803)cAg>cTg	p.Q1601L	WNK3_ENST00000375159.2_Missense_Mutation_p.Q1601L|WNK3_ENST00000375169.3_Missense_Mutation_p.Q1554L	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1554					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TGTCAAGGACTGGGGGCGGCT	0.383000													49	9					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355054	33355054	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:33355054C>T	ENST00000023064.4	-	4	617	c.426G>A	c.(424-426)gtG>gtA	p.V142V	SLC7A9_ENST00000587772.1_Silent_p.V142V|SLC7A9_ENST00000590341.1_Silent_p.V142V	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	142			V -> A (in dbSNP:rs12150889).		blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GCTTGCAGCCCACATAGAAGG	0.587000													16	19					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88926546	88926546	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:88926546C>T	ENST00000303236.3	-	1	548	c.247G>A	c.(247-249)Gga>Aga	p.G83R		NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	83					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TCCTGCTCTCccgcggctgcc	0.726000													12	13					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20232255	20232255	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr20:20232255A>G	ENST00000245957.5	+	20	2252	c.2176A>G	c.(2176-2178)Aaa>Gaa	p.K726E	C20orf26_ENST00000389656.3_Missense_Mutation_p.K82E|C20orf26_ENST00000377293.1_Missense_Mutation_p.K82E|C20orf26_ENST00000377309.2_Missense_Mutation_p.K82E	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	726										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TTTTAATGATAAAGATTATGC	0.493000													89	100					0	0	1	0	0
LINC00482	284185	broad.mit.edu	37	17	79278823	79278823	+	RNA	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:79278823G>A	ENST00000332012.5	-	0	770					NR_038080.1																						AGGTCCAGGTGAGCAGGGTCC	0.637000													6	16					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586563	56586563	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr18:56586563G>A	ENST00000336078.4	+	4	1820	c.1044G>A	c.(1042-1044)ccG>ccA	p.P348P	ZNF532_ENST00000591230.1_Silent_p.P348P|ZNF532_ENST00000589288.1_Silent_p.P348P|ZNF532_ENST00000591808.1_Silent_p.P348P|ZNF532_ENST00000591083.1_Silent_p.P348P	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P348P(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AAGGATCCCCGTCCTCTCCCG	0.507000													54	26					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573651	76573651	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:76573651C>G	ENST00000307431.8	+	21	3638	c.3253C>G	c.(3253-3255)Caa>Gaa	p.Q1085E	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.Q1037E|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.Q1013E|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.Q1089E	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1086	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAATAAATATCAAGAGCCTGA	0.343000													44	45					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73039707	73039707	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr10:73039707G>A	ENST00000335350.6	+	2	625	c.209G>A	c.(208-210)cGc>cAc	p.R70H	UNC5B_ENST00000373192.4_Missense_Mutation_p.R70H	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	70	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CTCCGCTGCCGCGCCTTCCCC	0.627000													84	70					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92982962	92982962	+	Missense_Mutation	SNP	C	C	A	rs143723171		TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:92982962C>A	ENST00000523629.1	-	11	1917	c.1463G>T	c.(1462-1464)cGc>cTc	p.R488L	RUNX1T1_ENST00000396218.1_Missense_Mutation_p.R461L|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.R451L|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.R488L|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.R451L|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.R499L|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.R461L|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.R451L	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	488					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GGCGACCGTGCGCTCCATCTT	0.617000													24	28					1.96895e-08	2.11334e-08	1	1	0
SLC26A7	115111	broad.mit.edu	37	8	92406045	92406045	+	Silent	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:92406045C>G	ENST00000276609.3	+	17	2036	c.1797C>G	c.(1795-1797)ggC>ggG	p.G599G	SLC26A7_ENST00000523719.1_Silent_p.G599G|SLC26A7_ENST00000309536.2_Silent_p.G599G|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	599	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACTGTAAAGGCAGGAGTGTGG	0.388000													63	125					0	0	1	0	0
HTR7P1	93164	broad.mit.edu	37	12	13154790	13154790	+	RNA	SNP	G	G	C	rs1291363	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:13154790G>C	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							CCAACTACCTGATCGTGTCCA	0.607000													3	18					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152651011	152651011	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:152651011T>G	ENST00000367255.5	-	78	15410	c.14809A>C	c.(14809-14811)Agc>Cgc	p.S4937R	SYNE1_ENST00000448038.1_Missense_Mutation_p.S4866R|SYNE1_ENST00000341594.5_Missense_Mutation_p.S4684R|SYNE1_ENST00000265368.4_Missense_Mutation_p.S4937R|SYNE1_ENST00000423061.1_Missense_Mutation_p.S4866R	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4937					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTCTCAAGCTGGACTGGACC	0.493000										HNSCC(10;0.0054)			82	154					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	897553	897553	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr7:897553G>A	ENST00000456758.2	+	19	2050	c.2050G>A	c.(2050-2052)Gtg>Atg	p.V684M	SUN1_ENST00000389574.3_Missense_Mutation_p.V412M|SUN1_ENST00000401592.1_Missense_Mutation_p.V495M|SUN1_ENST00000452783.2_Missense_Mutation_p.V392M|SUN1_ENST00000405266.1_Missense_Mutation_p.V532M|SUN1_ENST00000413514.2_Missense_Mutation_p.V293M|SUN1_ENST00000425407.2_Missense_Mutation_p.V412M			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	522	SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTGGCGACACGTGAAGACCGG	0.483000													86	197					0	0	1	0	0
RUFY3	22902	broad.mit.edu	37	4	71648890	71648890	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:71648890C>T	ENST00000226328.4	+	9	1540	c.977C>T	c.(976-978)tCc>tTc	p.S326F	RUFY3_ENST00000381006.3_Missense_Mutation_p.S326F|RUFY3_ENST00000502653.1_Missense_Mutation_p.S273F|RUFY3_ENST00000417478.2_Missense_Mutation_p.S386F|RUFY3_ENST00000536664.1_Missense_Mutation_p.S310F	NM_014961.3	NP_055776.1	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3	326					negative regulation of axonogenesis	filopodium|growth cone				endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	16		all_hematologic(202;0.248)	Lung(101;0.235)			ATACTGGAATCCAATCGGAAG	0.353000													12	4					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43818933	43818933	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr15:43818933C>T	ENST00000382031.1	+	5	6007	c.5976C>T	c.(5974-5976)gaC>gaT	p.D1992D	MAP1A_ENST00000300231.5_Silent_p.D1754D|MAP1A_ENST00000399453.1_Silent_p.D1754D			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1754						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGGCCTCAGACTTCAAGGATT	0.567000													64	94					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61854850	61854850	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:61854850C>A	ENST00000577390.1	-	6	1957	c.1003G>T	c.(1003-1005)Ggc>Tgc	p.G335C	CDH8_ENST00000577730.1_Missense_Mutation_p.G335C|CDH8_ENST00000584337.1_Missense_Mutation_p.G335C|CDH8_ENST00000299345.6_Missense_Mutation_p.G335C	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	335	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTTATAATGCCATCCTGGGCC	0.383000													33	63					2.47316e-13	2.78446e-13	1	1	0
C3orf17	25871	broad.mit.edu	37	3	112724609	112724609	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr3:112724609G>T	ENST00000314400.5	-	9	1669	c.1478C>A	c.(1477-1479)aCt>aAt	p.T493N	C3orf17_ENST00000383675.2_Missense_Mutation_p.T423N|C3orf17_ENST00000393857.2_Missense_Mutation_p.T357N	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	493						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						TCTATGCACAGTACAGTGTGA	0.418000													37	78					1.26612e-14	1.44571e-14	1	1	0
CREBBP	1387	broad.mit.edu	37	16	3781794	3781794	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:3781794T>C	ENST00000262367.5	-	29	5682	c.4873A>G	c.(4873-4875)Atg>Gtg	p.M1625V	CREBBP_ENST00000382070.3_Missense_Mutation_p.M1587V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1625	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.M1625V(1)|p.M1625L(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCTTCTCCATGGTGGCATAC	0.612000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						58	28					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913745	77913745	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:77913745G>T	ENST00000321110.1	-	2	468	c.173C>A	c.(172-174)gCc>gAc	p.A58D		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	58							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						GGGCTCCTTGGCCTCTGAGGA	0.572000													17	5					4.7546e-09	5.20742e-09	1	1	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643267	1643267	+	Silent	SNP	G	G	A	rs150695727	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:1643267G>A	ENST00000399682.1	-	1	101	c.57C>T	c.(55-57)tcC>tcT	p.S19S		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	19						keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccccacagccggagccacagc	0.687000													5	59					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65427085	65427085	+	Silent	SNP	A	A	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:65427085A>G	ENST00000519389.1	+	14	2681	c.2502A>G	c.(2500-2502)agA>agG	p.R834R	HEPH_ENST00000343002.2_Silent_p.R780R|HEPH_ENST00000336279.5_Silent_p.R513R|HEPH_ENST00000441993.2_Silent_p.R783R|HEPH_ENST00000419594.1_Silent_p.R591R|HEPH_ENST00000374727.3_Silent_p.R783R			Q9BQS7	HEPH_HUMAN	hephaestin	780	Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						TGGGTTCCAGATACAAGAAAG	0.468000													27	9					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													3	27					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191307	6191307	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:6191307G>T	ENST00000530810.1	-	1	331	c.250C>A	c.(250-252)Cta>Ata	p.L84I	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGATGGCTAGGGCCTTGGGC	0.483000													39	63					1.08169e-08	1.17671e-08	1	1	0
SASH1	23328	broad.mit.edu	37	6	148865655	148865655	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:148865655C>T	ENST00000367467.3	+	18	3524	c.3049C>T	c.(3049-3051)Cca>Tca	p.P1017S		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1017	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TCCCGATGCGCCATGCCTGCC	0.677000													28	46					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19740953	19740953	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:19740953C>T	ENST00000203556.4	-	21	2869	c.2732G>A	c.(2731-2733)cGg>cAg	p.R911Q	GMIP_ENST00000445806.2_Missense_Mutation_p.R882Q|GMIP_ENST00000587238.1_Missense_Mutation_p.R885Q	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	911					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCTGGGCCCCCGCCCCCGCAA	0.672000													11	23					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9449975	9449975	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:9449975A>G	ENST00000393883.2	+	4	788	c.140A>G	c.(139-141)tAt>tGt	p.Y47C	ZNF559_ENST00000592896.1_Missense_Mutation_p.Y75C|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000592504.1_Missense_Mutation_p.Y47C|ZNF559_ENST00000317221.7_Missense_Mutation_p.Y47C|ZNF559_ENST00000603380.1_Missense_Mutation_p.Y47C|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000587557.1_Missense_Mutation_p.Y111C|ZNF559_ENST00000586255.1_Missense_Mutation_p.Y75C|ZNF559_ENST00000585352.1_Missense_Mutation_p.Y47C|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000538743.1_Intron|ZNF177_ENST00000602738.1_Intron|ZNF177_ENST00000446085.4_Intron	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						CTGGAGAACTATAAGAATCTA	0.408000													80	105					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058221	56058221	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:56058221C>A	ENST00000313022.2	-	1	345	c.318G>T	c.(316-318)ttG>ttT	p.L106F		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					CAGCAGCTCCCAAGAAGACAA	0.428000													97	204					3.07327e-39	3.72028e-39	1	1	0
FAT1	2195	broad.mit.edu	37	4	187549662	187549662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:187549662G>A	ENST00000441802.2	-	8	4788	c.4579C>T	c.(4579-4581)Cag>Tag	p.Q1527*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1527	Cadherin 13.			HQHT -> SPAH (in Ref. 1; CAA60685).	actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGGGTGTGCTGGTGAACAGCT	0.488000										HNSCC(5;0.00058)			20	12					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207874869	207874869	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:207874869T>A	ENST00000508064.2	+	9	1294	c.1234T>A	c.(1234-1236)Tca>Aca	p.S412T	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	412	Sushi 7.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CACAGGTAAATCATGTGAAAC	0.433000													77	12					0	0	1	0	0
ZNF830	91603	broad.mit.edu	37	17	33289647	33289647	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:33289647G>A	ENST00000361952.3	+	1	1099	c.1062G>A	c.(1060-1062)gaG>gaA	p.E354E		NM_052857.3	NP_443089.3	Q96NB3	ZN830_HUMAN	zinc finger protein 830	354					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|liver(2)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(249;0.17)				GCGATGATGAGGGGGAACTAC	0.408000													40	58					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5249856	5249856	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr3:5249856C>T	ENST00000256497.4	+	8	1550	c.1417C>T	c.(1417-1419)Cct>Tct	p.P473S	EDEM1_ENST00000445686.1_Missense_Mutation_p.P278S	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	473					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TGGTGCCCTCCCTGAGAGATA	0.498000													68	30					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166845943	166845943	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:166845943C>G	ENST00000510118.1	-	17	1783	c.1443G>C	c.(1441-1443)gaG>gaC	p.E481D	RPS6KA2_ENST00000265678.4_Missense_Mutation_p.E456D|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.E464D|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.E367D|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.E367D			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	456	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GGATCTCAATCTCTTCCGAGG	0.522000													10	19					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10971010	10971010	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr3:10971010C>T	ENST00000254488.2	+	10	1422	c.1356C>T	c.(1354-1356)ctC>ctT	p.L452L		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	452					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TTCTGGGCCTCGTGATGTTAA	0.572000													86	62					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8386060	8386060	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:8386060G>A	ENST00000471889.1	+	4	1058	c.673G>A	c.(673-675)Gca>Aca	p.A225T	SLC45A1_ENST00000377479.2_Missense_Mutation_p.A259T|SLC45A1_ENST00000289877.8_Missense_Mutation_p.A225T			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	225					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTGCAGCCCCGCAGACCAGGA	0.657000													47	17					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324610	103324610	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:103324610G>A	ENST00000233969.2	+	12	2243	c.2101G>A	c.(2101-2103)Ggg>Agg	p.G701R		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	701						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CGCAGATGCCGGGACCACCGT	0.498000													48	70					0	0	1	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13927886	13927886	+	RNA	SNP	G	G	A	rs11649821	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:13927886G>A	ENST00000602743.1	-	0	224																											AACGGAGGGAGTGAGAGCCTT	0.562000													3	25					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107236418	107236418	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:107236418C>T	ENST00000392837.4	+	5	1039	c.888C>T	c.(886-888)ctC>ctT	p.L296L	RIC8B_ENST00000355478.2_Silent_p.L256L|RIC8B_ENST00000549643.1_Intron|RIC8B_ENST00000392839.2_Silent_p.L296L			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	296					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						TGGATGTTCTCATTTGTCCGT	0.358000													33	51					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21349925	21349925	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:21349925G>T	ENST00000256958.2	+	8	869	c.773G>T	c.(772-774)tGg>tTg	p.W258L		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	258					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GTTGGAGCTTGGTGGCTTAAT	0.348000													52	126					1.21353e-23	1.42612e-23	1	1	0
CEP78	84131	broad.mit.edu	37	9	80866898	80866898	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr9:80866898C>G	ENST00000424347.2	+	9	1433	c.1144C>G	c.(1144-1146)Ctt>Gtt	p.L382V	CEP78_ENST00000415759.2_Missense_Mutation_p.L383V|CEP78_ENST00000376597.4_Missense_Mutation_p.L383V|CEP78_ENST00000277082.5_Missense_Mutation_p.L382V|CEP78_ENST00000376598.2_Missense_Mutation_p.L382V			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	382					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						GCCCGCACCTCTTCCACCTGG	0.418000													7	11					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39311416	39311416	+	Missense_Mutation	SNP	C	C	T	rs147710831		TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:39311416C>T	ENST00000263408.4	-	7	1029	c.934G>A	c.(934-936)Gat>Aat	p.D312N		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	312	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGCACAACATCGCGATTTCTC	0.368000													53	71					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48602939	48602939	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:48602939G>T	ENST00000354276.3	-	5	763	c.436C>A	c.(436-438)Caa>Aaa	p.Q146K	PLA2G4C_ENST00000599921.1_Missense_Mutation_p.Q146K|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.Q156K|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.Q146K	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	146	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TCTCTGGTTTGCTTAGAGATA	0.542000													5	67					0.014758	0.0150382	1	1	0
FANCM	57697	broad.mit.edu	37	14	45628353	45628353	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr14:45628353C>T	ENST00000267430.5	+	9	1536	c.1451C>T	c.(1450-1452)tCa>tTa	p.S484L	FANCM_ENST00000542564.2_Missense_Mutation_p.S458L|FANCM_ENST00000556036.1_Missense_Mutation_p.S484L	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	484	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						ATCTTCTCTTCATTTCGAGAT	0.348000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				39	9					0	0	1	0	0
WDYHV1	55093	broad.mit.edu	37	8	124453639	124453639	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:124453639G>C	ENST00000523984.1	+	6	650	c.422G>C	c.(421-423)gGc>gCc	p.G141A	WDYHV1_ENST00000287387.2_Missense_Mutation_p.G201A|WDYHV1_ENST00000523356.1_3'UTR|WDYHV1_ENST00000518125.1_Missense_Mutation_p.G53A|WDYHV1_ENST00000517609.1_3'UTR			Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	201					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(3)	17						CATCGGTTTGGCAGTAAAAAC	0.423000													20	9					0	0	1	0	0
ZNF444	55311	broad.mit.edu	37	19	56671029	56671029	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:56671029G>A	ENST00000337080.3	+	5	810	c.443G>A	c.(442-444)gGg>gAg	p.G148E	ZNF444_ENST00000592949.1_Missense_Mutation_p.G147E|ZNF444_ENST00000592171.1_3'UTR	NM_001253792.1|NM_018337.3	NP_001240721.1|NP_060807.2	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	148					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|lung(5)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		CCGGCGCCTGGGGACTCCCAG	0.726000													3	0					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169938401	169938401	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:169938401A>G	ENST00000327239.4	+	5	1814	c.310A>G	c.(310-312)Aaa>Gaa	p.K104E	DHRS9_ENST00000412271.1_Missense_Mutation_p.K104E|DHRS9_ENST00000357546.2_Missense_Mutation_p.K104E|DHRS9_ENST00000602501.1_Missense_Mutation_p.K104E|DHRS9_ENST00000436483.2_Missense_Mutation_p.K104E|DHRS9_ENST00000432060.2_Missense_Mutation_p.K164E|DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000428522.1_Missense_Mutation_p.K104E	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	104					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AGTTGGGGAGAAAGGTGAGAG	0.493000													16	46					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77764355	77764355	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr7:77764355C>T	ENST00000354212.4	-	17	3267	c.3014G>A	c.(3013-3015)cGc>cAc	p.R1005H	MAGI2_ENST00000522391.1_Missense_Mutation_p.R1005H|MAGI2_ENST00000419488.1_Missense_Mutation_p.R991H	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1005	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGAATGATGCGAAGGGTGAC	0.577000													26	20					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80478021	80478021	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:80478021C>G	ENST00000335255.5	+	1	431	c.257C>G	c.(256-258)cCg>cGg	p.P86R		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	86	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			TTCAcgcccccgggcggcggc	0.731000													11	10					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205039043	205039043	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:205039043G>A	ENST00000331830.4	+	18	2569	c.2285G>A	c.(2284-2286)cGg>cAg	p.R762Q		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	762	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CAGACCGCCCGGGTGCCTGGC	0.652000													121	119					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37422978	37422978	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr10:37422978A>T	ENST00000374660.1	+	5	683	c.584A>T	c.(583-585)cAt>cTt	p.H195L	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.H195L|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.H195L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	251						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TGTGGATTTCATCAGTAAGTG	0.383000													135	2793					0	0	1	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499903	59499903	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr15:59499903T>C	ENST00000307144.4	+	1	862	c.764T>C	c.(763-765)aTa>aCa	p.I255T	MYO1E_ENST00000288235.4_Intron	NM_033195.2	NP_149972.1	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	255					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)	10					NADH(DB00157)	GGAGTGAACATAGCTGGTGTC	0.448000													34	58					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101717876	101717876	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr13:101717876C>T	ENST00000251127.6	-	40	4565	c.4484G>A	c.(4483-4485)cGg>cAg	p.R1495Q		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1495						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACGCAGTAGCCGCAGCAGGAA	0.572000													88	19					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131624166	131624166	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr3:131624166A>T	ENST00000512055.1	-	6	2248	c.122T>A	c.(121-123)cTt>cAt	p.L41H	CPNE4_ENST00000511604.1_Missense_Mutation_p.L41H|CPNE4_ENST00000502818.1_Missense_Mutation_p.L59H|CPNE4_ENST00000512332.1_Missense_Mutation_p.L59H|CPNE4_ENST00000429747.1_Missense_Mutation_p.L41H			Q96A23	CPNE4_HUMAN	copine IV	41	C2 1.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TGGTTTGGAAAGGGCATCTCT	0.517000													59	75					0	0	1	0	0
INO80B	83444	broad.mit.edu	37	2	74684886	74684886	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:74684886C>T	ENST00000233331.7	+	5	1060	c.966C>T	c.(964-966)tgC>tgT	p.C322C		NM_031288.3	NP_112578.2	Q9C086	IN80B_HUMAN	INO80 complex subunit B	322					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	13						GCTACGCTTGCTCCCGCACAG	0.706000													18	24					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158449877	158449877	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:158449877A>G	ENST00000355585.4	+	3	379	c.304A>G	c.(304-306)Act>Gct	p.T102A	SYNJ2_ENST00000367122.2_Missense_Mutation_p.T102A|SYNJ2_ENST00000449859.2_Missense_Mutation_p.T51A|SYNJ2_ENST00000367121.3_Missense_Mutation_p.T102A	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	102							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AATCACTGCCACTGACTTTTA	0.498000													29	56					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129012524	129012524	+	Silent	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:129012524T>C	ENST00000326639.6	+	7	736	c.525T>C	c.(523-525)ggT>ggC	p.G175G	LARP1B_ENST00000441387.1_Silent_p.G175G|LARP1B_ENST00000264584.5_Silent_p.G128G|LARP1B_ENST00000394288.3_Silent_p.G175G|LARP1B_ENST00000432347.2_Silent_p.G175G|LARP1B_ENST00000427266.1_Silent_p.G175G|LARP1B_ENST00000512292.1_Silent_p.G175G|LARP1B_ENST00000354456.3_5'UTR	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	175							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						ATTCATATGGTTATCAAGAAC	0.313000													30	15					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57535057	57535057	+	Silent	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:57535057G>T	ENST00000371236.2	-	8	902	c.639C>A	c.(637-639)ccC>ccA	p.P213P	DAB1_ENST00000371234.4_Silent_p.P213P|DAB1_ENST00000420954.2_Intron|DAB1_ENST00000371231.1_Silent_p.P213P|DAB1_ENST00000414851.2_Intron|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	213					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTTCCGTTTCGGGATCACGGA	0.408000													15	74					3.32936e-07	3.54985e-07	1	1	0
ALB	213	broad.mit.edu	37	4	74283319	74283319	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:74283319T>A	ENST00000295897.4	+	11	1450	c.1361T>A	c.(1360-1362)cTa>cAa	p.L454Q	ALB_ENST00000401494.3_Missense_Mutation_p.L339Q|ALB_ENST00000415165.2_Missense_Mutation_p.L262Q|ALB_ENST00000505649.1_Intron|ALB_ENST00000509063.1_Missense_Mutation_p.L454Q|ALB_ENST00000503124.1_Missense_Mutation_p.L304Q	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	454	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TCAAGAAACCTAGGAAAAGTG	0.363000													25	26					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39281904	39281904	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:39281904C>T	ENST00000426016.1	-	6	657	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	SOS1_ENST00000428721.2_Missense_Mutation_p.E134K|SOS1_ENST00000402219.2_Missense_Mutation_p.E191K|SOS1_ENST00000395038.2_Missense_Mutation_p.E191K			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	191					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				GAAGGCTCTTCGTCAGTTAAA	0.279000									Noonan syndrome				63	105					0	0	1	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880545	105880545	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:105880545A>C	ENST00000301919.4	-	3	2170	c.755T>G	c.(754-756)cTa>cGa	p.L252R		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	252						nucleus											CTCCTTCTCTAGCTGAAGCCG	0.463000													49	95					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763392	5763392	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr9:5763392C>T	ENST00000414202.2	+	19	2556	c.2365C>T	c.(2365-2367)Ctt>Ttt	p.L789F	KIAA1432_ENST00000251879.6_Missense_Mutation_p.L789F|KIAA1432_ENST00000381532.2_Missense_Mutation_p.L710F|KIAA1432_ENST00000449720.2_Missense_Mutation_p.L673F|KIAA1432_ENST00000418622.3_Missense_Mutation_p.L710F	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	789						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGCTTTAGTCCTTGGTGCTGT	0.473000													168	91					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140811698	140811698	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr9:140811698G>A	ENST00000371372.1	+	6	926	c.781G>A	c.(781-783)Gag>Aag	p.E261K	CACNA1B_ENST00000277551.2_Missense_Mutation_p.E261K|CACNA1B_ENST00000371363.1_Missense_Mutation_p.E261K|CACNA1B_ENST00000371355.4_Missense_Mutation_p.E261K|CACNA1B_ENST00000371357.1_Missense_Mutation_p.E261K|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	261					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGCAGATGCGGAGCCCGTGGG	0.612000													30	48					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496892	1496892	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:1496892G>A	ENST00000421627.2	+	2	167	c.33G>A	c.(31-33)ccG>ccA	p.P11P		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	90					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GGACCCAGCCGCCGCTGTGTT	0.706000													7	3					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30046468	30046468	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr14:30046468G>A	ENST00000331968.5	-	18	2944	c.2715C>T	c.(2713-2715)ctC>ctT	p.L905L	PRKD1_ENST00000415220.2_Silent_p.L913L	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	905					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CACGCTCACCGAGGGCTTTCA	0.478000													46	13					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615733	140615733	+	RNA	SNP	A	A	G	rs2907306	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:140615733A>G	ENST00000526308.1	+	0	1796					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GCCGCAGACCACGGCTCCCCG	0.667000													6	90					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585721	33585721	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:33585721T>A	ENST00000404816.2	+	27	4411	c.4058T>A	c.(4057-4059)cTc>cAc	p.L1353H	LTBP1_ENST00000402934.1_Missense_Mutation_p.L972H|LTBP1_ENST00000390003.4_Missense_Mutation_p.L1028H|LTBP1_ENST00000404525.1_Missense_Mutation_p.L974H|LTBP1_ENST00000272273.5_Missense_Mutation_p.L251H|LTBP1_ENST00000418533.2_Missense_Mutation_p.L985H|LTBP1_ENST00000354476.3_Missense_Mutation_p.L1354H|LTBP1_ENST00000407925.1_Missense_Mutation_p.L1027H			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1353	TB 3.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TACTATAATCTCAATGACGCC	0.418000													36	83					0	0	1	0	0
IGKV1D-8	28904	broad.mit.edu	37	2	90260018	90260018	+	RNA	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:90260018G>A	ENST00000471857.1	+	0	302																											AGGAGACAGAGTCACCATCAG	0.463000													57	110					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137694768	137694768	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr9:137694768G>A	ENST00000371817.3	+	39	3455	c.3041G>A	c.(3040-3042)cGt>cAt	p.R1014H		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1014	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATGGGTGAGCGTGGCCACCCT	0.602000													10	10					0	0	1	0	0
SOCS2	8835	broad.mit.edu	37	12	93968823	93968823	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:93968823G>A	ENST00000340600.2	+	3	1063	c.465G>A	c.(463-465)ccG>ccA	p.P155P	SOCS2_ENST00000549122.1_Silent_p.P155P|SOCS2_ENST00000549206.1_Silent_p.P155P|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000536696.2_Silent_p.P155P|SOCS2_ENST00000551556.1_Silent_p.P155P	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	155	SH2.|SOCS box.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity	p.P155P(1)		cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						TGACCAAACCGCTCTACACGT	0.502000													41	61					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19969136	19969136	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr22:19969136C>T	ENST00000263207.3	-	5	785	c.494G>A	c.(493-495)cGg>cAg	p.R165Q	ARVCF_ENST00000406259.1_Missense_Mutation_p.R165Q|ARVCF_ENST00000406522.1_Missense_Mutation_p.R102Q|ARVCF_ENST00000401994.1_Missense_Mutation_p.R102Q|ARVCF_ENST00000487793.1_5'UTR|ARVCF_ENST00000344269.3_Missense_Mutation_p.R102Q	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	165					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CAGGAAATGCCGGTCCAGGGC	0.682000													33	50					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029109	37029109	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:37029109C>A	ENST00000358047.3	+	1	2678	c.2626C>A	c.(2626-2628)Cct>Act	p.P876T		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	876										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGACTTTACCCCTGAGTGCAG	0.463000													46	12					5.20006e-24	6.15595e-24	1	1	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342197	60342197	+	RNA	SNP	T	T	C	rs76635225		TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:60342197T>C	ENST00000581291.1	-	0	1956																				breast(2)|kidney(1)|lung(2)	5						TGGGAGGGGCTGGGCATGGTT	0.488000													4	17					0	0	1	0	0
PPP1R17	10842	broad.mit.edu	37	7	31736590	31736590	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr7:31736590G>C	ENST00000342032.3	+	4	875	c.247G>C	c.(247-249)Gaa>Caa	p.E83Q	PPP1R17_ENST00000409146.3_Missense_Mutation_p.E32Q|PPP1R17_ENST00000498609.1_3'UTR	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	83					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											TGTGTTTTCAGAACATTTAAT	0.383000													31	66					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40689364	40689364	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:40689364G>A	ENST00000298910.7	+	23	3072	c.3014G>A	c.(3013-3015)tGt>tAt	p.C1005Y	LRRK2_ENST00000343742.2_Missense_Mutation_p.C1005Y	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1005					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CAGAAATGCTGTATAAGTGTT	0.388000													38	57					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917572	65917572	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr15:65917572C>A	ENST00000261892.6	+	2	1441	c.1154C>A	c.(1153-1155)gCa>gAa	p.A385E	SLC24A1_ENST00000546330.1_Missense_Mutation_p.A385E|SLC24A1_ENST00000544319.2_Missense_Mutation_p.A385E|SLC24A1_ENST00000537259.1_Missense_Mutation_p.A385E|SLC24A1_ENST00000399033.4_Missense_Mutation_p.A385E|SLC24A1_ENST00000339868.6_Missense_Mutation_p.A385E	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	385					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						ACGGTCAGGGCAAAGCTGACC	0.577000													35	61					1.62565e-12	1.81756e-12	1	1	0
AIMP2	7965	broad.mit.edu	37	7	6049123	6049123	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr7:6049123C>G	ENST00000223029.3	+	1	248	c.129C>G	c.(127-129)caC>caG	p.H43Q	AIMP2_ENST00000400479.2_Intron|AIMP2_ENST00000395236.2_Missense_Mutation_p.H43Q	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	43					apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						GCGCTGGCCACGTGCAGGTAG	0.776000													16	31					0	0	1	0	0
NOLC1	9221	broad.mit.edu	37	10	103912172	103912172	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr10:103912172C>T	ENST00000405356.1	+	1	240	c.5C>T	c.(4-6)gCg>gTg	p.A2V	NOLC1_ENST00000488254.2_Missense_Mutation_p.A2V|NOLC1_ENST00000605788.1_Missense_Mutation_p.A2V|NOLC1_ENST00000603742.1_5'UTR			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	2					mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		TGGAGGATGGCGGACGCCGGC	0.632000													30	22					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368530	18368530	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:18368530G>A	ENST00000392413.3	-	4	3779	c.3564C>T	c.(3562-3564)ccC>ccT	p.P1188P	KIAA1683_ENST00000600328.2_Silent_p.P1001P|KIAA1683_ENST00000600359.2_Silent_p.P955P	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	0						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CCCACGTGACGGGGTGGAGCA	0.667000													34	57					0	0	1	0	0
AMDHD2	51005	broad.mit.edu	37	16	2578082	2578082	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:2578082G>A	ENST00000302956.4	+	6	744	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	AMDHD2_ENST00000293971.6_Missense_Mutation_p.R217Q|AMDHD2_ENST00000413459.3_Missense_Mutation_p.R217Q|CEMP1_ENST00000382350.1_Intron|AMDHD2_ENST00000565570.1_Intron			Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2	217					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						GCTGACCTGCGGGCGGCAGAG	0.682000													48	24					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026258	16026258	+	Silent	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr8:16026258G>C	ENST00000350896.3	-	4	536	c.339C>G	c.(337-339)gtC>gtG	p.V113V	MSR1_ENST00000445506.2_Silent_p.V131V|MSR1_ENST00000262101.5_Silent_p.V113V|MSR1_ENST00000381998.4_Silent_p.V113V|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000355282.2_Silent_p.V113V	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	113					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity	p.V113V(1)		haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GTTCCATAAAGACTTCTTGAA	0.388000													72	56					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62261196	62261196	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:62261196C>A	ENST00000416284.3	-	2	1595	c.11G>T	c.(10-12)aGa>aTa	p.R4I	FAM19A2_ENST00000551449.1_Missense_Mutation_p.R4I|FAM19A2_ENST00000551619.1_Missense_Mutation_p.R4I	NM_178539.4	NP_848634.1	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	4						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		CTGTAAGTATCTCTTACTCAT	0.313000													36	50					4.34311e-12	4.82234e-12	1	1	0
HJURP	55355	broad.mit.edu	37	2	234749348	234749348	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:234749348C>T	ENST00000411486.2	-	8	2143	c.2078G>A	c.(2077-2079)cGc>cAc	p.R693H	HJURP_ENST00000441687.1_Missense_Mutation_p.R608H|HJURP_ENST00000432087.1_Missense_Mutation_p.R639H	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	693					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ATTGCCCTGGCGTCCGGAGCC	0.592000													62	24					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10387081	10387081	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr3:10387081G>T	ENST00000397077.1	-	17	3130	c.2555C>A	c.(2554-2556)gCc>gAc	p.A852D	ATP2B2_ENST00000383800.4_Missense_Mutation_p.A852D|ATP2B2_ENST00000360273.2_Missense_Mutation_p.A897D|ATP2B2_ENST00000352432.4_Missense_Mutation_p.A897D|ATP2B2_ENST00000343816.4_Missense_Mutation_p.A883D			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	897					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CGTGATGCAGGCGCCTGTGAA	0.622000													20	12					1.33834e-09	1.47584e-09	1	1	0
CLVS2	134829	broad.mit.edu	37	6	123319157	123319157	+	Silent	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:123319157C>A	ENST00000275162.4	+	2	1570	c.235C>A	c.(235-237)Cgg>Agg	p.R79R	CLVS2_ENST00000368438.1_Intron	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	79					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						CTTTGAGTACCGGCAGCAGAA	0.557000													58	92					4.96213e-28	5.9178e-28	1	1	0
OR8J3	81168	broad.mit.edu	37	11	55904585	55904585	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:55904585C>G	ENST00000301529.1	-	1	609	c.610G>C	c.(610-612)Gca>Cca	p.A204P		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AAATTTGTTGCTGCAGATATA	0.313000													40	73					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115858651	115858651	+	Silent	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:115858651T>A	ENST00000264363.2	-	5	1908	c.1230A>T	c.(1228-1230)ggA>ggT	p.G410G		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	410	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGATTGGTATTCCATGTTCCT	0.433000													21	11					0	0	1	0	0
FANCA	2175	broad.mit.edu	37	16	89807210	89807210	+	Splice_Site	SNP	A	A	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:89807210A>T	ENST00000389301.3	-	38	3859		c.e38+1		ZNF276_ENST00000289816.5_3'UTR|FANCA_ENST00000568369.1_Splice_Site	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A						DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GGTCTGACTTACATTTGAGGT	0.483000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				11	17					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106109985	106109985	+	RNA	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr14:106109985G>C	ENST00000390545.2	-	0	632																											TGGTTTTCTCGATGGGGGCTG	0.627000													4	31					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88723830	88723830	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr4:88723830T>C	ENST00000226284.5	+	4	197	c.130T>C	c.(130-132)Tat>Cat	p.Y44H		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	44					biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		GCCACGATATTATCTTTACAA	0.274000													35	21					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455101	84455101	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr13:84455101T>C	ENST00000377084.2	-	1	1427	c.542A>G	c.(541-543)cAc>cGc	p.H181R		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	181						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAGGTCGAGGTGGGTGATGGG	0.537000													67	30					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44737219	44737219	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr7:44737219C>T	ENST00000222673.5	+	17	2238	c.2196C>T	c.(2194-2196)ttC>ttT	p.F732F	OGDH_ENST00000543843.1_Silent_p.F683F|OGDH_ENST00000439616.2_Silent_p.F582F|OGDH_ENST00000447398.1_Silent_p.F743F|OGDH_ENST00000449767.1_Silent_p.F728F|OGDH_ENST00000444676.1_Silent_p.F747F	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	732				LGFA -> AGLR (in Ref. 1; BAA01393 and 2; BAA06836).	glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	AGCTGGGCTTCGCCATGGCCA	0.597000													52	84					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79226361	79226361	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:79226361C>T	ENST00000374759.3	-	13	1962	c.1579G>A	c.(1579-1581)Gcg>Acg	p.A527T	SLC38A10_ENST00000288439.5_Missense_Mutation_p.A527T	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	527					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TTTCCGCCCGCGTGTCTGGAT	0.622000													47	88					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47969742	47969742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr21:47969742C>T	ENST00000318711.7	+	22	2767	c.2584C>T	c.(2584-2586)Cag>Tag	p.Q862*	DIP2A_ENST00000457905.3_Nonsense_Mutation_p.Q861*|DIP2A_ENST00000427143.2_Nonsense_Mutation_p.Q797*|DIP2A_ENST00000417564.2_Nonsense_Mutation_p.Q861*|DIP2A_ENST00000400274.1_Nonsense_Mutation_p.Q857*	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	861					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGTGGCTGAGCAGCGGCCGGA	0.637000													52	29					0	0	1	0	0
SPIRE1	56907	broad.mit.edu	37	18	12493138	12493138	+	Silent	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr18:12493138T>C	ENST00000409402.4	-	8	1389	c.1122A>G	c.(1120-1122)ttA>ttG	p.L374L	SPIRE1_ENST00000410092.3_Silent_p.L374L|SPIRE1_ENST00000464481.1_5'UTR|SPIRE1_ENST00000453447.2_Silent_p.L254L|SPIRE1_ENST00000383356.2_Silent_p.L215L|SPIRE1_ENST00000309836.5_Silent_p.L177L	NM_001128626.1	NP_001122098.1	Q08AE8	SPIR1_HUMAN	spire-type actin nucleation factor 1	374	WH2 2.					cytoskeleton|perinuclear region of cytoplasm	actin binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)	28						TAATTTCTTCTAATATTCTTT	0.438000													30	46					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177196	89177196	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:89177196G>A	ENST00000561129.2	+	1	242	c.112G>A	c.(112-114)Gca>Aca	p.A38T	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.A38T			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						GAGAAATAACGCAGATACAGG	0.552000													35	7					0	0	1	0	0
MRPS18B	28973	broad.mit.edu	37	6	30585647	30585647	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:30585647C>T	ENST00000259873.4	+	1	162	c.5C>T	c.(4-6)gCg>gTg	p.A2V	MRPS18B_ENST00000472229.1_3'UTR|MRPS18B_ENST00000506373.2_Missense_Mutation_p.A2V	NM_014046.3	NP_054765.1	Q9Y676	RT18B_HUMAN	mitochondrial ribosomal protein S18B	2					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(2)	13						GTCAAGATGGCGGCGTCTGTA	0.537000													30	39					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188074	140188074	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:140188074G>A	ENST00000530339.1	+	1	1302	c.1302G>A	c.(1300-1302)tcG>tcA	p.S434S	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.S434S|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.S434S|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGCCTTCGCTGTGGGCCA	0.612000													76	53					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369375	86369375	+	Silent	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr13:86369375C>A	ENST00000400286.2	-	2	1867	c.1269G>T	c.(1267-1269)ctG>ctT	p.L423L		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	423						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTAATTTGGTCAGGTGGTTAC	0.348000													10	108					1.76689e-08	1.90919e-08	1	1	0
EXOC6B	23233	broad.mit.edu	37	2	72725629	72725629	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:72725629C>T	ENST00000272427.6	-	13	1421	c.1291G>A	c.(1291-1293)Gac>Aac	p.D431N	EXOC6B_ENST00000410104.1_Missense_Mutation_p.D431N	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	431					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						CTATATTGGTCTCTGATTTCT	0.353000													12	16					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612366	179612366	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:179612366T>C	ENST00000360870.5	-	46	14983	c.14761A>G	c.(14761-14763)Aaa>Gaa	p.K4921E	TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1048	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTGTCTTTAGTTTCAGGA	0.433000													52	124					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381889	101381889	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:101381889G>T	ENST00000372780.1	+	3	306	c.87G>T	c.(85-87)aaG>aaT	p.K29N	TCEAL2_ENST00000329035.2_Missense_Mutation_p.K29N	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						ACGAGGGAAAGCCAGAAGTAG	0.423000													34	13					3.90053e-15	4.48561e-15	1	1	0
KIZ-AS1	101929591	broad.mit.edu	37	20	21143487	21143487	+	RNA	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr20:21143487G>T	ENST00000591761.1	-	0	5091				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							GTCGCCACTTGCAGATCATCT	0.458000													8	22					0.0381472	0.0383856	1	1	0
CXCR2P1	3580	broad.mit.edu	37	2	218925149	218925149	+	RNA	SNP	G	G	A	rs6758271	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:218925149G>A	ENST00000439871.1	-	0	1231					NR_002712.1																						TGATCAAGCCGTGTATGGCTA	0.502000													4	49					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342186	60342186	+	RNA	SNP	T	T	C	rs79096325		TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:60342186T>C	ENST00000581291.1	-	0	1967																				breast(2)|kidney(1)|lung(2)	5						GCTGGGGGTGTTGGGAGGGGC	0.498000													4	12					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80045897	80045897	+	Silent	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:80045897C>T	ENST00000306749.2	-	18	3017	c.2799G>A	c.(2797-2799)ctG>ctA	p.L933L		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	933					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCCGTACCTCCAGGGACACTG	0.667000													36	72					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25011639	25011639	+	Silent	SNP	A	A	G	rs60849220	by1000genomes	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr20:25011639A>G	ENST00000537502.1	-	1	1669	c.138T>C	c.(136-138)ttT>ttC	p.F46F	ACSS1_ENST00000432802.2_Intron|ACSS1_ENST00000323482.4_Intron|ACSS1_ENST00000542618.1_Intron			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	0	Poly-Ala.				acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAGGAGGGCCAAAATGCAGAG	0.517000													3	23					0	0	1	0	0
ZNF417	147687	broad.mit.edu	37	19	58420556	58420556	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr19:58420556T>A	ENST00000312026.5	-	3	1254	c.1090A>T	c.(1090-1092)Aag>Tag	p.K364*	CTD-2583A14.9_ENST00000602124.1_Intron|ZNF417_ENST00000536263.1_Nonsense_Mutation_p.K165*|ZNF417_ENST00000595559.1_Nonsense_Mutation_p.K363*	NM_152475.2	NP_689688.2	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		AAGCAGAACTTCTGACGAAAA	0.433000													88	63					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111701420	111701420	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:111701420C>A	ENST00000435970.1	-	13	1801	c.985G>T	c.(985-987)Gac>Tac	p.D329Y	REV3L_ENST00000368802.3_Missense_Mutation_p.D407Y|REV3L_ENST00000358835.3_Missense_Mutation_p.D407Y|REV3L_ENST00000368805.1_Missense_Mutation_p.D407Y			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	407					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GGACTACTGTCCACTATAAAA	0.433000								DNA polymerases (catalytic subunits)					47	67					1.7489e-18	2.02571e-18	1	1	0
IFNA17	3451	broad.mit.edu	37	9	21227775	21227775	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr9:21227775G>C	ENST00000413767.2	-	1	446	c.398C>G	c.(397-399)cCc>cGc	p.P133R		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	133					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATTCATCAGGGGAGTCTCTTC	0.453000													254	71					0	0	1	0	0
CCDC121	79635	broad.mit.edu	37	2	27850447	27850447	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:27850447C>T	ENST00000324364.3	-	2	400	c.220G>A	c.(220-222)Gaa>Aaa	p.E74K	CCDC121_ENST00000394775.3_Missense_Mutation_p.E236K|ZNF512_ENST00000556601.1_Intron|RP11-158I13.2_ENST00000505973.1_RNA	NM_024584.4	NP_078860.2	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121	74										breast(1)|endometrium(3)|large_intestine(2)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(172;0.155)					GAGGCTGATTCTTGTCTTCTT	0.403000													136	209					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18145527	18145527	+	Missense_Mutation	SNP	C	C	T	rs150245335	byFrequency	TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:18145527C>T	ENST00000316843.4	+	20	3026	c.2930C>T	c.(2929-2931)cCa>cTa	p.P977L		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	977					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					AACGGGACCCCAAGCATCCTG	0.617000													7	140					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12164245	12164245	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:12164245G>A	ENST00000379388.2	+	9	8040	c.7708G>A	c.(7708-7710)Gaa>Aaa	p.E2570K	HIVEP1_ENST00000541134.1_Missense_Mutation_p.E435K	NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	2570					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GGGAGCTCCAGAAATGCCAGC	0.542000													23	16					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127843862	127843862	+	Silent	SNP	G	G	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr10:127843862G>T	ENST00000368679.4	-	4	582	c.273C>A	c.(271-273)gcC>gcA	p.A91A	ADAM12_ENST00000368676.4_Silent_p.A91A	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	91					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TGAAACTGCTGGCAATGAGAC	0.433000													9	76					0.000274275	0.000286742	1	1	0
FAM47C	442444	broad.mit.edu	37	X	37029110	37029110	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chrX:37029110C>T	ENST00000358047.3	+	1	2679	c.2627C>T	c.(2626-2628)cCt>cTt	p.P876L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	876										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GACTTTACCCCTGAGTGCAGA	0.468000													45	12					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61473152	61473152	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:61473152C>G	ENST00000424789.2	+	16	2882	c.2878C>G	c.(2878-2880)Ctc>Gtc	p.L960V	RP11-269G24.3_ENST00000583552.1_RNA|AC015923.1_ENST00000431604.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.L960V	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	960							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						TCATGCTGCACTCCGAGGTCA	0.498000													15	6					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2602465	2602465	+	Silent	SNP	C	C	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr12:2602465C>A	ENST00000399655.1	+	7	1291	c.1026C>A	c.(1024-1026)ggC>ggA	p.G342G	CACNA1C_ENST00000399638.1_Silent_p.G342G|CACNA1C_ENST00000399595.1_Silent_p.G342G|CACNA1C_ENST00000406454.3_Silent_p.G342G|CACNA1C_ENST00000344100.3_Silent_p.G342G|CACNA1C_ENST00000399591.1_Silent_p.G342G|CACNA1C_ENST00000335762.5_Silent_p.G342G|CACNA1C_ENST00000399606.1_Silent_p.G342G|CACNA1C_ENST00000399603.1_Silent_p.G342G|CACNA1C_ENST00000480911.1_Silent_p.G342G|CACNA1C_ENST00000327702.7_Silent_p.G342G|CACNA1C_ENST00000399629.1_Silent_p.G342G|CACNA1C_ENST00000399634.1_Silent_p.G342G|CACNA1C_ENST00000399597.1_Silent_p.G342G|CACNA1C_ENST00000399644.1_Silent_p.G342G|CACNA1C_ENST00000399637.1_Silent_p.G342G|CACNA1C_ENST00000402845.3_Silent_p.G342G|CACNA1C_ENST00000399649.1_Silent_p.G342G|CACNA1C_ENST00000399601.1_Silent_p.G342G|CACNA1C_ENST00000399621.1_Silent_p.G342G|CACNA1C_ENST00000399641.1_Silent_p.G342G|CACNA1C_ENST00000347598.4_Silent_p.G342G|CACNA1C_ENST00000399617.1_Silent_p.G342G	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	342					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCAAGCACGGCATCACCAACT	0.607000													80	161					6.86016e-32	8.24243e-32	1	1	0
SGTB	54557	broad.mit.edu	37	5	64976529	64976529	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr5:64976529G>C	ENST00000381007.4	-	7	807	c.572C>G	c.(571-573)tCa>tGa	p.S191*		NM_019072.2	NP_061945.1	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	191							binding			large_intestine(3)|lung(3)|skin(3)	9		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		TTTCAGATTTGACTTATAGGA	0.368000													26	92					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097229	167097229	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr1:167097229G>A	ENST00000361200.2	+	6	3027	c.2861G>A	c.(2860-2862)tGg>tAg	p.W954*	DUSP27_ENST00000271385.5_Nonsense_Mutation_p.W954*|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Nonsense_Mutation_p.W954*			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	954	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CAAAGTGACTGGTCTGGAAGT	0.483000													15	41					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128350410	128350410	+	Silent	SNP	G	G	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:128350410G>A	ENST00000389524.4	+	17	2087	c.2034G>A	c.(2032-2034)tcG>tcA	p.S678S	MYO7B_ENST00000428314.1_Silent_p.S678S|MYO7B_ENST00000409816.2_Silent_p.S678S			Q6PIF6	MYO7B_HUMAN	myosin VIIB	678	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCGATACTCGGGCATGATGG	0.657000													8	7					0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113418038	113418039	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:113418038_113418039insA	ENST00000272542.3	+	9	2221_2222	c.1682_1683insA	c.(1681-1683)catfs	p.H561fs		NM_005415.4	NP_005406.3	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate transporter), member 1	561					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						GTGGCAACACCAATATGGCTTC	0.455													104	138	---	---	---	---					
CYP20A1	57404	broad.mit.edu	37	2	204150380	204150380	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr2:204150380delA	ENST00000356079.4	+	9	1019	c.896delA	c.(895-897)cafs	p.Q299fs	CYP20A1_ENST00000429815.2_Frame_Shift_Del_p.Q307fs|CYP20A1_ENST00000461371.1_3'UTR	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	299						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						GAAGAAGTTCAAAAAAAATTA	0.348													7	220	---	---	---	---					
SYNCRIP	10492	broad.mit.edu	37	6	86332353	86332354	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr6:86332353_86332354insT	ENST00000355238.6	-	8	1060_1061	c.854_855insA	c.(853-855)aagfs	p.K285fs	SYNCRIP_ENST00000369622.3_Frame_Shift_Ins_p.K285fs	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	285	RRM 2.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		AAAAGCCTCTGTTTTTTTTCTT	0.411													7	271	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24762969	24762970	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr10:24762969_24762970insC	ENST00000376451.2	+	2	1073_1074	c.813_814insC	c.(811-816)atccaafs	p.Q272fs	KIAA1217_ENST00000396446.1_Frame_Shift_Ins_p.Q272fs|KIAA1217_ENST00000458595.1_Frame_Shift_Ins_p.Q554fs|KIAA1217_ENST00000376454.3_Frame_Shift_Ins_p.Q554fs|KIAA1217_ENST00000376452.3_Frame_Shift_Ins_p.Q554fs|KIAA1217_ENST00000430453.2_Frame_Shift_Ins_p.Q475fs|KIAA1217_ENST00000307544.6_Frame_Shift_Ins_p.Q272fs|KIAA1217_ENST00000396445.1_Frame_Shift_Ins_p.Q272fs|KIAA1217_ENST00000376462.1_Frame_Shift_Ins_p.Q474fs			Q5T5P2	SKT_HUMAN	KIAA1217	554					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CGGCGACAATACCCAAAGACAG	0.550													30	12	---	---	---	---					
H2AFX	3014	broad.mit.edu	37	11	118965860	118965860	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr11:118965860delC	ENST00000530167.1	-	1	317	c.245delG	c.(244-246)ccfs	p.R82fs		NM_002105.2	NP_002096.1	P16104	H2AX_HUMAN	H2A histone family, member X	82					DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding			lung(3)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		CTGCAGGTGGCGGGGGATGAT	0.662								Chromatin Structure			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	120	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95696016	95696016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr13:95696016delT	ENST00000376887.4	-	29	3769	c.3655delA	c.(3655-3657)tcfs	p.I1219fs	ABCC4_ENST00000412704.1_Frame_Shift_Del_p.I1172fs	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1219	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCTCCCGGATTTTTTTTTGT	0.378													7	166	---	---	---	---					
SMG1P4	100507526	broad.mit.edu	37	16	21893285	21893299	+	RNA	DEL	TATTGGTTAGCTTGT	TATTGGTTAGCTTGT	-			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr16:21893285_21893299delTATTGGTTAGCTTGT	ENST00000540706.1	-	0	1710																											GTAATTAAAATATTGGTTAGCTTGTATTCCTATGC	0.335													17	8	---	---	---	---					
WSCD1	23302	broad.mit.edu	37	17	6021339	6021350	+	In_Frame_Del	DEL	CCGACGCACCAT	CCGACGCACCAT	-			TCGA-CQ-A4CI-01A-11D-A25Y-08	TCGA-CQ-A4CI-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcadacd-7540-4143-ab82-15889248d286	83a03ed6-2b0b-42f5-bac6-d5146df9c520	g.chr17:6021339_6021350delCCGACGCACCAT	ENST00000574946.1	+	8	1596_1607	c.1206_1217delCCGACGCACCAT	c.(1204-1218)agc>ag	p.SRRTI402del	WSCD1_ENST00000573634.1_In_Frame_Del_p.SRRTI286del|WSCD1_ENST00000574232.1_In_Frame_Del_p.SRRTI402del|WSCD1_ENST00000539421.1_In_Frame_Del_p.SRRTI402del|WSCD1_ENST00000317744.5_In_Frame_Del_p.SRRTI402del			Q658N2	WSCD1_HUMAN	WSC domain containing 1	402						integral to membrane	sulfotransferase activity	p.R404H(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						ACTGGCGGAGCCGACGCACCATCTGTGTCAAA	0.552													29	39	---	---	---	---					
