Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C5AR1	728	broad.mit.edu	37	19	47823557	47823557	+	Missense_Mutation	SNP	C	C	T	rs141160351		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:47823557C>T	ENST00000355085.3	+	2	545	c.523C>T	c.(523-525)Cgg>Tgg	p.R175W		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	175					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CTTCCTGTACCGGGTGGTCCG	0.632000													29	133					0	0	0.007291	0	0
PLA2G3	50487	broad.mit.edu	37	22	31535944	31535944	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:31535944C>T	ENST00000215885.3	-	1	649	c.397G>A	c.(397-399)Gca>Aca	p.A133T		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	133					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGCCCTGCTGCTCGCTTCTTC	0.632000													6	77					0	0	0.001984	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944807	43944807	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:43944807C>T	ENST00000389420.3	-	2	357	c.358G>A	c.(358-360)Gac>Aac	p.D120N	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.D120N	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	120						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGCCCTGCGTCGCTCTCCCAG	0.662000													5	29					0	0	0.000602	0	0
INADL	10207	broad.mit.edu	37	1	62263043	62263043	+	Missense_Mutation	SNP	C	C	G	rs145732252		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:62263043C>G	ENST00000371158.2	+	11	1459	c.1345C>G	c.(1345-1347)Cta>Gta	p.L449V	INADL_ENST00000316485.6_Missense_Mutation_p.L449V	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	449	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						ACACCTAACCCTAGTTCGAAG	0.443000													27	96					0	0	0.004656	0	0
FSTL4	23105	broad.mit.edu	37	5	132652310	132652310	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:132652310C>T	ENST00000265342.7	-	5	693	c.444G>A	c.(442-444)ttG>ttA	p.L148L		NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	148						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGACATTCTTCAAGCGGGCGT	0.547000											OREG0016777	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	80					0	0	0.006214	0	0
TNS1	7145	broad.mit.edu	37	2	218713727	218713727	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:218713727C>T	ENST00000171887.4	-	17	1590	c.1138G>A	c.(1138-1140)Ggg>Agg	p.G380R	TNS1_ENST00000430930.1_Missense_Mutation_p.G380R|TNS1_ENST00000419504.1_Missense_Mutation_p.G380R|TNS1_ENST00000480665.1_5'UTR	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	380						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TTAACAGCCCCGGTGCTGCCG	0.607000													41	163					0	0	0.007835	0	0
SVEP1	79987	broad.mit.edu	37	9	113308490	113308490	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:113308490C>G	ENST00000401783.2	-	3	1205	c.869G>C	c.(868-870)cGa>cCa	p.R290P	SVEP1_ENST00000302728.8_Missense_Mutation_p.R290P|SVEP1_ENST00000374461.1_Missense_Mutation_p.R267P|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374469.1_Missense_Mutation_p.R267P	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	290					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GCTTCCCATTCGGTCACAGCA	0.443000													3	1					0	0	0.004672	0	0
PTGS1	5742	broad.mit.edu	37	9	125154466	125154466	+	Splice_Site	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:125154466A>G	ENST00000362012.2	+	11	1449		c.e11-1		PTGS1_ENST00000223423.4_Splice_Site|PTGS1_ENST00000373698.5_Splice_Site|PTGS1_ENST00000540753.1_Splice_Site	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)						cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATCTCCTTGTAGGAGAGAAGG	0.488000													10	24					0	0	0.006214	0	0
LYST	1130	broad.mit.edu	37	1	235940477	235940477	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:235940477G>A	ENST00000389794.3	-	17	5520	c.5346C>T	c.(5344-5346)agC>agT	p.S1782S	LYST_ENST00000536965.1_3'UTR|LYST_ENST00000389793.2_Silent_p.S1782S			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1782					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTAATAAGATGCTCTGAACTT	0.378000													21	84					0	0	0.012319	0	0
MICALL2	79778	broad.mit.edu	37	7	1477796	1477796	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:1477796G>A	ENST00000297508.7	-	12	2423	c.2248C>T	c.(2248-2250)Cgg>Tgg	p.R750W	MICALL2_ENST00000471899.1_5'UTR|MICALL2_ENST00000405088.4_Missense_Mutation_p.R538W	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	750						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCGTCCAGCCGCCTCTCGATG	0.726000													5	8					0	0	0.000602	0	0
CPO	130749	broad.mit.edu	37	2	207824389	207824389	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:207824389G>A	ENST00000272852.3	+	5	453	c.407G>A	c.(406-408)cGc>cAc	p.R136H		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	136					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		TCAAGTATACGCAAGCTCCTT	0.353000													4	46					0	0	0.000602	0	0
NLRP1	22861	broad.mit.edu	37	17	5486116	5486116	+	Missense_Mutation	SNP	G	G	C	rs141118572		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:5486116G>C	ENST00000345221.3	-	2	876	c.322C>G	c.(322-324)Ccc>Gcc	p.P108A	NLRP1_ENST00000572272.1_Missense_Mutation_p.P108A|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000577119.1_Missense_Mutation_p.P108A|NLRP1_ENST00000262467.5_Missense_Mutation_p.P108A|NLRP1_ENST00000354411.3_Missense_Mutation_p.P108A|NLRP1_ENST00000269280.4_Missense_Mutation_p.P108A	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	108					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GGTTGGCTGGGAGACCCCAGG	0.602000													9	37					0	0	0.006214	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19413942	19413942	+	Silent	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:19413942C>G	ENST00000538714.1	+	7	601	c.597C>G	c.(595-597)ctC>ctG	p.L199L	PLEKHA5_ENST00000359180.3_Silent_p.L199L|PLEKHA5_ENST00000299275.6_Silent_p.L199L|PLEKHA5_ENST00000539256.1_Intron|PLEKHA5_ENST00000543806.1_Silent_p.L91L|PLEKHA5_ENST00000317589.4_Silent_p.L199L|PLEKHA5_ENST00000309364.4_Silent_p.L199L|PLEKHA5_ENST00000424268.1_Silent_p.L91L|PLEKHA5_ENST00000510738.2_3'UTR|PLEKHA5_ENST00000355397.3_Silent_p.L199L|PLEKHA5_ENST00000429027.2_Silent_p.L199L	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	199	PH.						1-phosphatidylinositol binding|protein binding	p.L199L(2)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCTTTGCCTCTTTTATTATA	0.303000													21	123					0	0	0.003330	0	0
RP11-468E2.4	0	broad.mit.edu	37	14	24629560	24629560	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:24629560C>T	ENST00000558468.1	+	12	1534	c.1534C>T	c.(1534-1536)Cgc>Tgc	p.R512C	RNF31_ENST00000324103.6_Missense_Mutation_p.R1037C|RNF31_ENST00000382687.3_Missense_Mutation_p.R886C|RNF31_ENST00000559275.1_Missense_Mutation_p.R886C																							CCTGCACGTACGCCCCCAGCC	0.582000											OREG0022619	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	111					0	0	0.002780	0	0
TSPYL5	85453	broad.mit.edu	37	8	98290036	98290036	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:98290036C>T	ENST00000322128.3	-	1	140	c.37G>A	c.(37-39)Gcc>Acc	p.A13T		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	13					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CGGTTTTTGGCGCGGGAGGAC	0.692000													4	26					0	0	0.000602	0	0
TCAIM	285343	broad.mit.edu	37	3	44399311	44399311	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:44399311G>C	ENST00000342649.4	+	3	535	c.108G>C	c.(106-108)ttG>ttC	p.L36F	TCAIM_ENST00000396078.3_Missense_Mutation_p.L36F|TCAIM_ENST00000383746.3_Missense_Mutation_p.L36F|TCAIM_ENST00000417237.1_Missense_Mutation_p.L36F	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		TCAATGCCTTGAGGCCTTTCT	0.388000													6	24					0	0	0.001984	0	0
PRSS12	8492	broad.mit.edu	37	4	119219987	119219987	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:119219987T>C	ENST00000296498.3	-	9	2020	c.1738A>G	c.(1738-1740)Atc>Gtc	p.I580V		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	580	SRCR 4.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						TCTTGCTTGATACAGTCAGCC	0.448000													12	63					0	0	0.010729	0	0
UNC79	57578	broad.mit.edu	37	14	94120290	94120290	+	Silent	SNP	G	G	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:94120290G>C	ENST00000553484.1	+	39	6538	c.6384G>C	c.(6382-6384)ggG>ggC	p.G2128G	UNC79_ENST00000555664.1_Silent_p.G2067G|UNC79_ENST00000256339.4_Silent_p.G1929G|UNC79_ENST00000393151.2_Silent_p.G2106G			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2106						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TTCCAGATGGGACTTTTTTAC	0.483000													5	162					0	0	0.001168	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155924729	155924729	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:155924729C>G	ENST00000368316.1	-	18	2133	c.1663G>C	c.(1663-1665)Gag>Cag	p.E555Q	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.E583Q|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.E584Q|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.E582Q|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.E555Q			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	583	PH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCCTCTGTCTCAATCAGGGGG	0.478000													14	71					0	0	0.002450	0	0
ZMYM6	9204	broad.mit.edu	37	1	35484994	35484994	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:35484994G>A	ENST00000357182.4	-	4	615	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L	ZMYM6_ENST00000373340.2_Silent_p.L130L|ZMYM6_ENST00000317538.5_Silent_p.L130L|ZMYM6_ENST00000493328.1_Intron|ZMYM6_ENST00000373333.1_Silent_p.L130L|ZMYM6_ENST00000487874.1_Silent_p.L130L	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	130					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGAGGTGGCAGGCAGGCAGGT	0.403000													14	42					0	0	0.001855	0	0
PTPRD	5789	broad.mit.edu	37	9	8499728	8499728	+	Silent	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:8499728A>G	ENST00000381196.4	-	22	2784	c.2241T>C	c.(2239-2241)taT>taC	p.Y747Y	PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Silent_p.Y747Y|PTPRD_ENST00000360074.4_Silent_p.Y734Y|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Silent_p.Y734Y|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Silent_p.Y747Y|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	747	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATGCACCTGATATCCTCTTA	0.498000										TSP Lung(15;0.13)			16	88					0	0	0.004990	0	0
FAT4	79633	broad.mit.edu	37	4	126412581	126412581	+	Silent	SNP	C	C	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126412581C>A	ENST00000394329.3	+	17	14617	c.14604C>A	c.(14602-14604)ccC>ccA	p.P4868P	FAT4_ENST00000335110.5_Silent_p.P3109P	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4868				P -> S (in Ref. 4; BAB15534).	homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAGAATGCCCAAATTATCTC	0.458000													17	46					3.52763e-06	3.86095e-06	0.004990	1	0
ALKBH2	121642	broad.mit.edu	37	12	109530419	109530419	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:109530419C>T	ENST00000429722.2	-	2	536	c.173G>A	c.(172-174)cGg>cAg	p.R58Q	ALKBH2_ENST00000343075.3_Missense_Mutation_p.R58Q|ALKBH2_ENST00000440112.2_Missense_Mutation_p.R58Q	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	58					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CCGAATGTGCCGCCAGCTAGG	0.547000								Direct reversal of damage					22	132					0	0	0.012319	0	0
TRPC4	7223	broad.mit.edu	37	13	38211559	38211559	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:38211559C>T	ENST00000379705.3	-	11	3272	c.2415G>A	c.(2413-2415)ccG>ccA	p.P805P	TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379673.2_Intron|TRPC4_ENST00000358477.2_Intron|TRPC4_ENST00000379679.1_Silent_p.P632P|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000379681.3_Silent_p.P810P|TRPC4_ENST00000338947.5_Silent_p.P632P			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	805	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTGCTGATCTCGGATGAATCA	0.443000													10	79					0	0	0.010729	0	0
ZNF649	65251	broad.mit.edu	37	19	52394087	52394087	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:52394087C>A	ENST00000354957.3	-	5	1586	c.1302G>T	c.(1300-1302)gaG>gaT	p.E434D	CTC-429C10.2_ENST00000600329.1_RNA|ZNF649_ENST00000600738.1_Missense_Mutation_p.E406D	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCTCACACTCATCACAGC	0.438000													27	145					3.01185e-09	3.34918e-09	0.003954	1	0
LAMA3	3909	broad.mit.edu	37	18	21330961	21330961	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:21330961C>T	ENST00000313654.9	+	5	1005	c.764C>T	c.(763-765)gCa>gTa	p.A255V	LAMA3_ENST00000399516.3_Missense_Mutation_p.A255V	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	255	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTACCAAGGCAACAAACATC	0.473000													33	85					0	0	0.012213	0	0
YTHDC1	91746	broad.mit.edu	37	4	69203343	69203343	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:69203343G>A	ENST00000344157.4	-	3	741	c.406C>T	c.(406-408)Cgg>Tgg	p.R136W	YTHDC1_ENST00000355665.3_Missense_Mutation_p.R136W|YTHDC1_ENST00000579690.1_Missense_Mutation_p.R136W	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	136										NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						TCCCTTTTCCGGACACAGGTT	0.403000													5	43					0	0	0.000602	0	0
REV3L	5980	broad.mit.edu	37	6	111697700	111697700	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:111697700C>T	ENST00000435970.1	-	15	2440	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K	REV3L_ENST00000368802.3_Missense_Mutation_p.E620K|REV3L_ENST00000358835.3_Missense_Mutation_p.E620K|REV3L_ENST00000368805.1_Missense_Mutation_p.E620K			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	620					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TAAGTGCTTTCGTTTGTAAAA	0.333000								DNA polymerases (catalytic subunits)					9	50					0	0	0.008291	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192500	132192500	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:132192500G>A	ENST00000359827.3	-	2	1915	c.953C>T	c.(952-954)gCg>gTg	p.A318V	PLXNA4_ENST00000423507.2_Missense_Mutation_p.A318V|PLXNA4_ENST00000321063.4_Missense_Mutation_p.A318V|PLXNA4_ENST00000378539.5_Missense_Mutation_p.A318V			Q9HCM2	PLXA4_HUMAN	plexin A4	318	Sema.					integral to membrane|intracellular|plasma membrane		p.A318V(3)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CACGGCCCCCGCTTTGGACAG	0.582000													7	42					0	0	0.004482	0	0
GZMK	3003	broad.mit.edu	37	5	54320494	54320494	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:54320494A>T	ENST00000231009.2	+	2	141	c.71A>T	c.(70-72)aAt>aTt	p.N24I	CTD-2313F11.1_ENST00000595218.1_RNA|CTD-2313F11.1_ENST00000596137.1_RNA|CTD-2313F11.1_ENST00000596909.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	24					proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GTAGGTTTCAATATGGAAATT	0.383000													7	19					0	0	0.003080	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121505	27121505	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:27121505C>T	ENST00000288699.6	+	2	296	c.138C>T	c.(136-138)ggC>ggT	p.G46G	DPYSL5_ENST00000401478.1_Silent_p.G46G	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	46					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	p.G46G(1)		breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCCCTGGCGGGGCCAAGG	0.592000													14	57					0	0	0.001855	0	0
TAAR6	319100	broad.mit.edu	37	6	132891604	132891604	+	Silent	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:132891604T>C	ENST00000275198.1	+	1	144	c.144T>C	c.(142-144)ttT>ttC	p.F48F		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	48						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TGGCTGTGTTTGGAAACCTCC	0.527000													18	110					0	0	0.006122	0	0
C7orf49	78996	broad.mit.edu	37	7	134852541	134852541	+	Silent	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:134852541A>G	ENST00000430372.1	-	3	478	c.153T>C	c.(151-153)acT>acC	p.T51T	C7orf49_ENST00000459937.1_Intron|C7orf49_ENST00000424142.1_5'UTR|C7orf49_ENST00000483029.2_5'UTR|C7orf49_ENST00000393114.3_Silent_p.T52T	NM_001243751.1|NM_024033.3	NP_001230680.1|NP_076938.2	Q9BWK5	MRI_HUMAN	chromosome 7 open reading frame 49	52						cytoplasm				endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						TGCAGTACACAGTCCTTGTCG	0.473000													3	86					0	0	0.004672	0	0
TP53	7157	broad.mit.edu	37	17	7578177	7578177	+	Splice_Site	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7578177C>T	ENST00000420246.2	-	6	804	c.672_splice	c.e6+1	p.E224_splice	TP53_ENST00000445888.2_Splice_Site_p.E224_splice|TP53_ENST00000359597.4_Splice_Site_p.E224_splice|TP53_ENST00000413465.2_Splice_Site_p.E224_splice|TP53_ENST00000455263.2_Splice_Site_p.E224_splice|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Splice_Site_p.E224_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	224	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E224D(20)|p.?(13)|p.E224E(12)|p.0?(8)|p.E131D(3)|p.E131E(2)|p.V218_E224delVPYEPPE(1)|p.V225fs*24(1)|p.E224_V225insXX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACCAGACCTCAGGCGGCT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	24					0	0	0.009096	0	0
MAPK14	1432	broad.mit.edu	37	6	36020563	36020563	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:36020563C>T	ENST00000229795.3	+	2	651	c.204C>T	c.(202-204)acC>acT	p.T68T	MAPK14_ENST00000468133.1_5'UTR|MAPK14_ENST00000310795.4_Silent_p.T68T|MAPK14_ENST00000229794.4_Silent_p.T68T	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	68	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						CGAAAAGAACCTACAGAGAAC	0.378000													8	36					0	0	0.003080	0	0
SDAD1P1	157489	broad.mit.edu	37	8	26238106	26238106	+	RNA	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:26238106G>A	ENST00000519902.1	-	0	1842																											TCAAGTGAACGGCTAAAAAGT	0.388000													4	37					0	0	0.000602	0	0
ZNF761	388561	broad.mit.edu	37	19	53958193	53958193	+	RNA	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:53958193T>C	ENST00000454407.1	+	0	885							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GATCAAGCTTTCATTCGCATC	0.393000													17	108					0	0	0.004990	0	0
ACACA	31	broad.mit.edu	37	17	35591984	35591984	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:35591984C>T	ENST00000353139.5	-	25	3633	c.3152G>A	c.(3151-3153)cGa>cAa	p.R1051Q	ACACA_ENST00000394406.2_Missense_Mutation_p.R1014Q|ACACA_ENST00000360679.3_Missense_Mutation_p.R956Q|ACACA_ENST00000335166.5_Missense_Mutation_p.R936Q	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1014					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTCTCTTCTCGGAGGGCGAA	0.393000													11	49					0	0	0.008291	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420319	56420319	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:56420319C>T	ENST00000407595.2	+	2	1486	c.984C>T	c.(982-984)caC>caT	p.H328H	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	328	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCCTGAACACGCCAGGCACA	0.662000													11	112					0	0	0.010729	0	0
FAT4	79633	broad.mit.edu	37	4	126242740	126242740	+	Splice_Site	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126242740A>G	ENST00000394329.3	+	1	5187	c.5175_splice	c.e1+1	p.E1725_splice		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1725	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGAGAGCAGAGGTAATGATT	0.353000													8	28					0	0	0.003080	0	0
KLHL15	80311	broad.mit.edu	37	X	24024381	24024381	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:24024381C>T	ENST00000328046.8	-	3	685	c.430G>A	c.(430-432)Ggc>Agc	p.G144S		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	144	BACK.									autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						ATGTTTACGCCGAAATCATCT	0.428000													13	18					0	0	0.003163	0	0
PTGIS	5740	broad.mit.edu	37	20	48130868	48130868	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:48130868G>A	ENST00000244043.4	-	7	949	c.920C>T	c.(919-921)gCt>gTt	p.A307V	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	307					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GCGGACAGCAGCCAGGGCTTC	0.577000													8	57					0	0	0.004482	0	0
PRDM15	63977	broad.mit.edu	37	21	43287419	43287419	+	Silent	SNP	C	C	T	rs137957423		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr21:43287419C>T	ENST00000269844.3	-	5	719	c.609G>A	c.(607-609)gcG>gcA	p.A203A	PRDM15_ENST00000422911.1_Intron|PRDM15_ENST00000398548.1_Intron|PRDM15_ENST00000538201.1_Intron	NM_022115.3	NP_071398.3	P57071	PRD15_HUMAN	PR domain containing 15	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CTCCTCCGTTCGCAATCTTCC	0.532000													20	119					0	0	0.012319	0	0
ERBB4	2066	broad.mit.edu	37	2	212495211	212495211	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:212495211G>A	ENST00000342788.4	-	17	2365	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	ERBB4_ENST00000402597.1_Silent_p.A675A|ERBB4_ENST00000436443.1_Silent_p.A685A	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	685					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATCTTCTCAAGGCTCTTTTCT	0.393000										TSP Lung(8;0.080)			14	80					0	0	0.002450	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927037	130927037	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:130927037G>A	ENST00000261655.4	-	8	972	c.809C>T	c.(808-810)cCa>cTa	p.P270L	RIMBP2_ENST00000536002.1_Missense_Mutation_p.P178L|RIMBP2_ENST00000535703.1_Missense_Mutation_p.P178L	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	270						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TATGTGGGTTGGGGAGTGGAG	0.577000													15	110					0	0	0.004007	0	0
MS4A14	84689	broad.mit.edu	37	11	60183772	60183772	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:60183772A>T	ENST00000300187.6	+	5	1608	c.1331A>T	c.(1330-1332)aAc>aTc	p.N444I	MS4A14_ENST00000531787.1_Missense_Mutation_p.N332I|MS4A14_ENST00000531783.1_Missense_Mutation_p.N477I|MS4A14_ENST00000395005.2_Missense_Mutation_p.N427I	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	444	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						CAACCAGAAAACACTGAACCT	0.413000													10	51					0	0	0.010729	0	0
LRRC6	23639	broad.mit.edu	37	8	133622493	133622493	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:133622493G>A	ENST00000519595.1	-	10	1157	c.1059C>T	c.(1057-1059)gtC>gtT	p.V353V	LRRC6_ENST00000250173.1_Silent_p.V353V|LRRC6_ENST00000518642.1_Silent_p.V350V			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	353	CS.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTGCAGGAAGGACAAGCTGAA	0.418000													10	67					0	0	0.010729	0	0
EPHA6	285220	broad.mit.edu	37	3	96706230	96706230	+	Silent	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:96706230A>G	ENST00000389672.5	+	3	545	c.507A>G	c.(505-507)gtA>gtG	p.V169V	EPHA6_ENST00000470610.2_Silent_p.V169V|EPHA6_ENST00000542517.1_Silent_p.V75V	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	74	Ephrin-binding.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CATACCAGGTATGTAATGTAA	0.378000													16	127					0	0	0.007413	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769049	31769049	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:31769049G>A	ENST00000240587.4	-	2	1977	c.1650C>T	c.(1648-1650)atC>atT	p.I550I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	550					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGGCGGCATGGATGCTGGGAT	0.552000													12	130					0	0	0.013537	0	0
KIF14	9928	broad.mit.edu	37	1	200550381	200550381	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:200550381G>A	ENST00000367350.4	-	20	3721	c.3283C>T	c.(3283-3285)Cag>Tag	p.Q1095*		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1095	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TTGGCTTCCTGAATCATCATT	0.338000													9	68					0	0	0.006214	0	0
USP17L2	377630	broad.mit.edu	37	8	11996173	11996173	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:11996173G>T	ENST00000333796.3	-	1	413	c.97C>A	c.(97-99)Cag>Aag	p.Q33K	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	33					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						GAAGTCCGCTGGATTTCAGCA	0.527000													17	82					1.33834e-09	1.50023e-09	0.007413	1	0
SERGEF	26297	broad.mit.edu	37	11	18028145	18028145	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:18028145C>A	ENST00000265965.5	-	3	496	c.345G>T	c.(343-345)atG>atT	p.M115I	RP1-59M18.2_ENST00000525523.1_RNA|SERGEF_ENST00000532265.1_Start_Codon_SNP_p.M1I|SERGEF_ENST00000528200.1_Missense_Mutation_p.M115I|SERGEF_ENST00000532212.1_5'UTR	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	115					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						CACCTGTGAGCATAATCGTAA	0.468000													14	86					2.61681e-11	2.95721e-11	0.002450	1	0
MTMR8	55613	broad.mit.edu	37	X	63579362	63579362	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:63579362C>T	ENST00000374852.3	-	2	137	c.70G>A	c.(70-72)Gct>Act	p.A24T	MTMR8_ENST00000453546.1_Missense_Mutation_p.A24T	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	24						nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						ATCCCATTAGCTGGTTTCTTA	0.408000													14	18					0	0	0.004007	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108828	90108828	+	RNA	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:90108828C>G	ENST00000390271.2	+	0	119																											CAGCTTTCCTCTCTGTGACTC	0.478000													9	50					0	0	0.008291	0	0
NID2	22795	broad.mit.edu	37	14	52481904	52481904	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:52481904C>T	ENST00000216286.5	-	15	3117	c.3118G>A	c.(3118-3120)Gtg>Atg	p.V1040M	NID2_ENST00000541773.1_Missense_Mutation_p.V939M	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	1040	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CACTGGGGCACGTACTGGTCA	0.632000													17	81					0	0	0.004990	0	0
OR4X1	390113	broad.mit.edu	37	11	48285470	48285470	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:48285470A>G	ENST00000320048.1	+	1	58	c.58A>G	c.(58-60)Agt>Ggt	p.S20G		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						CCAGAATTGGAGTGAGCAGAG	0.453000													3	55					0	0	0.004672	0	0
SCARNA2	677766	broad.mit.edu	37	1	109642857	109642857	+	RNA	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:109642857C>T	ENST00000458748.1	+	0	43					NR_003023.1																						GTGTTGTGTGCGGAGCTGTGG	0.662000													5	18					0	0	0.001984	0	0
LAMA2	3908	broad.mit.edu	37	6	129687384	129687384	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:129687384G>A	ENST00000421865.2	+	33	4787	c.4738G>A	c.(4738-4740)Ggc>Agc	p.G1580S		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1580	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAGTGCACTGGCCTTCTTCT	0.468000													11	88					0	0	0.013537	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79054873	79054873	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:79054873C>T	ENST00000388820.4	-	23	4985	c.4775G>A	c.(4774-4776)cGc>cAc	p.R1592H		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1592	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CTTGACCAGGCGCCGCTGGAC	0.677000													3	12					0	0	0.009096	0	0
ZNF548	147694	broad.mit.edu	37	19	57911175	57911175	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57911175C>G	ENST00000366197.5	+	3	1770	c.1520C>G	c.(1519-1521)tCc>tGc	p.S507C	AC003002.6_ENST00000596400.1_Intron|AC003002.6_ENST00000600421.1_Intron|ZNF548_ENST00000336128.7_Missense_Mutation_p.S519C|AC004076.7_ENST00000597410.1_Intron	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTGTGTGCTCCATGAATGTG	0.408000													9	44					0	0	0.006214	0	0
SLC4A4	8671	broad.mit.edu	37	4	72215743	72215743	+	Silent	SNP	A	A	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:72215743A>T	ENST00000340595.3	+	2	568	c.372A>T	c.(370-372)ggA>ggT	p.G124G	SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000264485.5_Silent_p.G168G|SLC4A4_ENST00000351898.6_Silent_p.G168G|SLC4A4_ENST00000512686.1_Silent_p.G124G|SLC4A4_ENST00000425175.1_Silent_p.G168G	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	168						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGGAGAAAGGATCCATCATGC	0.453000													15	70					0	0	0.003163	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67176566	67176566	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:67176566C>T	ENST00000312390.5	+	9	984	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	TBC1D10C_ENST00000542590.1_Missense_Mutation_p.P319S|TBC1D10C_ENST00000526387.1_Missense_Mutation_p.P254L	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	319						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TCGAGCCATCCCCCCCGCGCA	0.692000													4	13					0	0	0.009096	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731697	140731697	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:140731697A>C	ENST00000523390.1	+	1	1870	c.1870A>C	c.(1870-1872)Aca>Cca	p.T624P	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGGTGCGCACAGCGCGTGC	0.706000													9	57					0	0	0.001855	0	0
MCF2L2	23101	broad.mit.edu	37	3	183041051	183041051	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:183041051C>T	ENST00000328913.3	-	6	872	c.575G>A	c.(574-576)cGc>cAc	p.R192H	MCF2L2_ENST00000447025.2_Missense_Mutation_p.R192H|MCF2L2_ENST00000414362.2_Missense_Mutation_p.R192H|MCF2L2_ENST00000473233.1_Missense_Mutation_p.R192H	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	192	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CTGACCGTGGCGATATTCCAA	0.488000													23	79					0	0	0.003330	0	0
KRT38	8687	broad.mit.edu	37	17	39594347	39594347	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:39594347G>T	ENST00000246646.3	-	6	1238	c.1239C>A	c.(1237-1239)tgC>tgA	p.C413*		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	413	Tail.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				ACACGTACTTGCAGTCCTCGC	0.527000													8	54					0.000157383	0.000169584	0.003080	1	0
PIK3CA	5290	broad.mit.edu	37	3	178921549	178921549	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:178921549T>G	ENST00000263967.3	+	5	1188	c.1031T>G	c.(1030-1032)gTg>gGg	p.V344G		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	344					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.V344G(8)|p.V344A(5)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GCAACCTACGTGAATGTAAAT	0.303000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	44					0	0	0.006214	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810420	106810420	+	Silent	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:106810420A>G	ENST00000526355.1	-	4	1440	c.972T>C	c.(970-972)tgT>tgC	p.C324C	GUCY1A2_ENST00000282249.2_Silent_p.C324C|GUCY1A2_ENST00000347596.2_Silent_p.C324C	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	324					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GGAAGGCTCTACAGAAGGTGT	0.458000													9	25					0	0	0.006214	0	0
ACD	65057	broad.mit.edu	37	16	67693460	67693460	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67693460G>A	ENST00000219251.8	-	4	973	c.642C>T	c.(640-642)ccC>ccT	p.P214P	ACD_ENST00000393919.4_Silent_p.P217P	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	217					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCCGTAGCCGGGGCTGCTCCG	0.677000													4	48					0	0	0.009096	0	0
SMC1B	27127	broad.mit.edu	37	22	45782901	45782901	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:45782901C>T	ENST00000357450.4	-	11	1756	c.1757G>A	c.(1756-1758)aGg>aAg	p.R586K	SMC1B_ENST00000404354.3_Missense_Mutation_p.R586K	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	586	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTTAAGCTCCCTTAGTCTTTC	0.328000													34	93					0	0	0.003755	0	0
MUC16	94025	broad.mit.edu	37	19	9066782	9066782	+	Silent	SNP	C	C	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:9066782C>A	ENST00000397910.4	-	3	20867	c.20664G>T	c.(20662-20664)gcG>gcT	p.A6888A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6890	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCACATTAGTCGCTGCTGTGC	0.483000													37	177					6.53348e-20	7.44388e-20	0.003755	1	0
PREX1	57580	broad.mit.edu	37	20	47296246	47296246	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:47296246G>A	ENST00000396220.1	-	12	1504	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	PREX1_ENST00000371941.3_Silent_p.F494F			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	494	DEP 1.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CGTCGTAGCGGAAGCGATACA	0.612000													16	95					0	0	0.006122	0	0
SP140L	93349	broad.mit.edu	37	2	231264899	231264899	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:231264899G>A	ENST00000243810.6	+	15	1255	c.1255G>A	c.(1255-1257)Gac>Aac	p.D419N	SP140L_ENST00000444636.1_Missense_Mutation_p.D419N|SP140L_ENST00000415673.2_Missense_Mutation_p.D419N|SP140L_ENST00000396563.4_Missense_Mutation_p.D384N			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	419						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						GTTCTGTTGCGACACTTGTTC	0.498000													21	79					0	0	0.012319	0	0
MKL1	57591	broad.mit.edu	37	22	40825661	40825661	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:40825661C>T	ENST00000396617.3	-	7	840	c.250G>A	c.(250-252)Gtg>Atg	p.V84M	MKL1_ENST00000402630.1_Missense_Mutation_p.V84M|MKL1_ENST00000402042.1_Missense_Mutation_p.V84M|MKL1_ENST00000407029.1_Missense_Mutation_p.V84M|MKL1_ENST00000355630.3_Missense_Mutation_p.V84M			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	84	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						TTCTTCTCCACCAGCTCCATG	0.572000			T	RBM15	acute megakaryocytic leukemia								6	68					0	0	0.001168	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75376271	75376271	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:75376271G>A	ENST00000555647.1	-	8	1532	c.1245C>T	c.(1243-1245)ccC>ccT	p.P415P	RPS6KL1_ENST00000557413.1_Silent_p.P415P|RPS6KL1_ENST00000354625.2_Silent_p.P384P|RPS6KL1_ENST00000358328.4_Silent_p.P415P			Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	415	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GCAGGTTCCCGGGGTGGAGGT	0.672000													12	45					0	0	0.002450	0	0
ASXL3	80816	broad.mit.edu	37	18	31319491	31319491	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:31319491C>G	ENST00000269197.5	+	11	2123	c.2123C>G	c.(2122-2124)tCc>tGc	p.S708C		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	708	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCACCAGTATCCAACTTACCT	0.393000													37	204					0	0	0.004289	0	0
PREX2	80243	broad.mit.edu	37	8	69031723	69031723	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:69031723A>G	ENST00000288368.4	+	28	3755	c.3478A>G	c.(3478-3480)Agt>Ggt	p.S1160G		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1160					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CAAGATACATAGTTGCCTTGA	0.388000													48	55					0	0	0.014410	0	0
MVP	9961	broad.mit.edu	37	16	29848052	29848052	+	Missense_Mutation	SNP	C	C	T	rs150165807		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:29848052C>T	ENST00000357402.5	+	7	820	c.682C>T	c.(682-684)Cac>Tac	p.H228Y	MVP_ENST00000452209.2_Missense_Mutation_p.A42V|MVP_ENST00000395353.1_Missense_Mutation_p.H228Y	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	228					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						GACAGCCCTGCACCTCCGGGC	0.622000													4	46					0	0	0.009096	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378185	55378185	+	Nonstop_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:55378185A>G	ENST00000326321.3	+	9	1400	c.1367A>G	c.(1366-1368)tAg>tGg	p.*456W	KIR3DL1_ENST00000402254.2_Nonstop_Mutation_p.*456W|KIR3DL2_ENST00000270442.5_Nonstop_Mutation_p.*439W	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GGGGTTTTCTAGGGAGACAAC	0.527000													3	180					0	0	0.009096	0	0
MAGED1	9500	broad.mit.edu	37	X	51640125	51640125	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:51640125G>A	ENST00000375695.2	+	5	1695	c.1542G>A	c.(1540-1542)caG>caA	p.Q514Q	MAGED1_ENST00000375722.1_Silent_p.Q458Q|MAGED1_ENST00000326587.7_Silent_p.Q458Q|MAGED1_ENST00000375772.3_Silent_p.Q458Q|MAGED1_ENST00000494718.1_3'UTR	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	458	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GTGCCTCACAGAACCCAGGTG	0.577000										Multiple Myeloma(10;0.10)			4	19					0	0	0.009096	0	0
TMEM115	11070	broad.mit.edu	37	3	50392907	50392907	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:50392907T>C	ENST00000266025.3	-	2	1469	c.923A>G	c.(922-924)gAt>gGt	p.D308G	XXcos-LUCA11.5_ENST00000606589.1_Intron	NM_007024.4	NP_008955.1	Q12893	TM115_HUMAN	transmembrane protein 115	308					negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus				breast(2)|endometrium(1)|lung(1)|prostate(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCATCATCATCCATGCTGGG	0.607000													9	36					0	0	0.004482	0	0
SYBU	55638	broad.mit.edu	37	8	110587403	110587403	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:110587403C>T	ENST00000399066.3	-	6	2442	c.1715G>A	c.(1714-1716)aGa>aAa	p.R572K	SYBU_ENST00000424158.2_Missense_Mutation_p.R580K|SYBU_ENST00000446070.2_Missense_Mutation_p.R574K|SYBU_ENST00000276646.9_Missense_Mutation_p.R575K|SYBU_ENST00000528647.1_Missense_Mutation_p.R574K|SYBU_ENST00000419099.1_Missense_Mutation_p.R574K|SYBU_ENST00000533895.1_Missense_Mutation_p.R574K|SYBU_ENST00000529175.1_Missense_Mutation_p.R369K|SYBU_ENST00000533171.1_Missense_Mutation_p.R575K|SYBU_ENST00000532779.1_Missense_Mutation_p.R507K|SYBU_ENST00000433638.1_Missense_Mutation_p.R575K|SYBU_ENST00000408908.2_Missense_Mutation_p.R575K|SYBU_ENST00000422135.1_Missense_Mutation_p.R575K|SYBU_ENST00000440310.1_Missense_Mutation_p.R575K|SYBU_ENST00000528331.1_Missense_Mutation_p.R456K|SYBU_ENST00000529690.1_Missense_Mutation_p.R445K|SYBU_ENST00000533065.1_Missense_Mutation_p.R456K|SYBU_ENST00000408889.3_Missense_Mutation_p.R456K	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	575						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						ATCCAGCTCTCTCATGAGGCG	0.552000													6	83					0	0	0.001984	0	0
METTL2A	339175	broad.mit.edu	37	17	60501347	60501347	+	Silent	SNP	G	G	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:60501347G>T	ENST00000311506.5	+	1	120	c.84G>T	c.(82-84)ccG>ccT	p.P28P		NM_181725.3	NP_859076.3	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	28							methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|upper_aerodigestive_tract(2)	6			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			TGAGAGATCCGGCGCGCGTCT	0.647000											OREG0024635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	45					0.000157383	0.000169584	0.003080	1	0
NAGS	162417	broad.mit.edu	37	17	42083545	42083545	+	Silent	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:42083545G>A	ENST00000293404.3	+	3	973	c.855G>A	c.(853-855)ctG>ctA	p.L285L		NM_153006.2	NP_694551.1	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	285					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CCAAGGCGCTGCGGCCCACCA	0.667000													11	38					0	0	0.001855	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6058428	6058428	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:6058428T>C	ENST00000409021.3	-	12	2152	c.1703A>G	c.(1702-1704)gAa>gGa	p.E568G	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E403G|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E568G|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E383G|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E568G	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	568	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACGCACCTTTTCCAGCAAGTC	0.542000													18	72					0	0	0.014323	0	0
POLR1B	84172	broad.mit.edu	37	2	113331325	113331325	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:113331325C>T	ENST00000263331.5	+	14	3038	c.2458C>T	c.(2458-2460)Cag>Tag	p.Q820*	POLR1B_ENST00000541869.1_Nonsense_Mutation_p.Q858*|POLR1B_ENST00000537335.1_Nonsense_Mutation_p.Q609*|POLR1B_ENST00000409894.3_Nonsense_Mutation_p.Q637*|POLR1B_ENST00000417433.2_Nonsense_Mutation_p.Q764*	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	820					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						AGCAAAACTGCAGTACGGAGA	0.448000													19	105					0	0	0.008871	0	0
LILRA4	23547	broad.mit.edu	37	19	54848799	54848799	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:54848799A>G	ENST00000291759.4	-	5	880	c.824T>C	c.(823-825)cTc>cCc	p.L275P		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	275	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGCCTGGGAGAGCCCAGCCTG	0.667000													3	57					0	0	0.004672	0	0
WDR7	23335	broad.mit.edu	37	18	54591315	54591315	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:54591315C>T	ENST00000254442.3	+	22	3900	c.3689C>T	c.(3688-3690)gCc>gTc	p.A1230V	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Missense_Mutation_p.A1197V	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	1230										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		GAACTTTGTGCCGATGCCGAG	0.438000													4	135					0	0	0.009096	0	0
ZNF10	7556	broad.mit.edu	37	12	133732617	133732617	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:133732617A>T	ENST00000248211.6	+	5	1007	c.785A>T	c.(784-786)gAg>gTg	p.E262V	ZNF268_ENST00000416488.1_Intron|ZNF10_ENST00000402932.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.E262V|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	262				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ATACATAGAGAGAAACCCTAT	0.398000													5	49					0	0	0.000602	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273547	26273547	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:26273547G>A	ENST00000377733.2	+	1	404	c.344G>A	c.(343-345)gGc>gAc	p.G115D		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	115					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						GTGTCGGAGGGCACCAAGGCG	0.567000													15	55					0	0	0.002450	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963951	88963951	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:88963951A>G	ENST00000333190.4	+	4	2264	c.1655A>G	c.(1654-1656)tAt>tGt	p.Y552C		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	552						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAGAGGAAATATAATTTGGAC	0.343000										HNSCC(36;0.09)			4	40					0	0	0.000602	0	0
SRCAP	10847	broad.mit.edu	37	16	30750152	30750152	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:30750152C>T	ENST00000262518.4	+	34	9176	c.8791C>T	c.(8791-8793)Ctg>Ttg	p.L2931L	SRCAP_ENST00000344771.4_Silent_p.L2773L|SRCAP_ENST00000395059.2_Silent_p.L2869L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2931	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CAATCCCCTCCTGTCACCTGT	0.572000													12	79					0	0	0.002450	0	0
KLHL30	377007	broad.mit.edu	37	2	239049729	239049729	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:239049729C>T	ENST00000409223.1	+	2	441	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C	KLHL30_ENST00000305959.4_Missense_Mutation_p.R94C			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	112										lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CACGGCTGCGCGCCTGCACTT	0.667000													18	81					0	0	0.004990	0	0
LCNL1	401562	broad.mit.edu	37	9	139879239	139879239	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:139879239A>G	ENST00000408973.2	+	3	865	c.271A>G	c.(271-273)Aaa>Gaa	p.K91E	LCNL1_ENST00000432827.1_Intron	NM_207510.3	NP_997393.3	Q6ZST4	LCNL1_HUMAN	lipocalin-like 1	91							binding										GGAGATGCGGAAAGGGGGCCT	0.662000													7	9					0	0	0.001984	0	0
C2orf83	56918	broad.mit.edu	37	2	228476326	228476326	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:228476326C>T	ENST00000264387.4	-	3	323	c.237G>A	c.(235-237)agG>agA	p.R79R	C2orf83_ENST00000409066.1_3'UTR	NM_020161.3	NP_064546.3	Q53S99	CB083_HUMAN	chromosome 2 open reading frame 83	79						membrane	folic acid binding|reduced folate carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(2)	11						CGGTAAGTTTCCTCATCCCTG	0.468000													18	65					0	0	0.006122	0	0
EPHA3	2042	broad.mit.edu	37	3	89478308	89478308	+	Silent	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:89478308T>C	ENST00000336596.2	+	12	2352	c.2127T>C	c.(2125-2127)agT>agC	p.S709S	EPHA3_ENST00000494014.1_Silent_p.S709S	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	709	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCTTGGATAGTTTCCTACGTG	0.323000										TSP Lung(6;0.00050)			12	34					0	0	0.004990	0	0
POMP	51371	broad.mit.edu	37	13	29252224	29252224	+	Silent	SNP	A	A	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:29252224A>G	ENST00000380842.4	+	6	492	c.411A>G	c.(409-411)aaA>aaG	p.K137K	POMP_ENST00000460403.1_3'UTR	NM_015932.5	NP_057016.1	Q9Y244	POMP_HUMAN	proteasome maturation protein	137					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex				endometrium(2)|kidney(1)|large_intestine(1)	4		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		TGGAATATAAACTTGGTTTAC	0.358000													11	40					0	0	0.008291	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986053	11986053	+	RNA	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:11986053G>A	ENST00000434078.2	+	0	608					NR_027425.1																						CACAATGATAGGCATTCTCTC	0.507000													4	46					0	0	0.000602	0	0
TMEM145	284339	broad.mit.edu	37	19	42818774	42818774	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:42818774G>A	ENST00000598766.1	+	4	313	c.313G>A	c.(313-315)Gcc>Acc	p.A105T	TMEM145_ENST00000301204.3_Missense_Mutation_p.A95T|TMEM145_ENST00000601020.1_3'UTR			Q8NBT3	TM145_HUMAN	transmembrane protein 145	95						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GGACTGCCTGGCCAAGGAGTC	0.642000													14	131					0	0	0.001855	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508732	106508732	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:106508732C>T	ENST00000359195.3	+	2	1036	c.726C>T	c.(724-726)ggC>ggT	p.G242G	PIK3CG_ENST00000496166.1_Silent_p.G242G|PIK3CG_ENST00000440650.2_Silent_p.G242G	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	242					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						ACACCCCCGGCGCCATCCTGC	0.527000													18	98					0	0	0.006122	0	0
USP20	10868	broad.mit.edu	37	9	132637882	132637882	+	Silent	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:132637882C>T	ENST00000315480.4	+	21	2420	c.2262C>T	c.(2260-2262)gtC>gtT	p.V754V	USP20_ENST00000358355.1_Silent_p.V754V|USP20_ENST00000372429.3_Silent_p.V754V			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	754	DUSP 1.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				ACCTGGTGGTCATCCTGCCCC	0.622000													26	61					0	0	0.006320	0	0
CNTROB	116840	broad.mit.edu	37	17	7842957	7842957	+	Missense_Mutation	SNP	C	C	T	rs141146363		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7842957C>T	ENST00000380262.3	+	8	1979	c.1054C>T	c.(1054-1056)Cgg>Tgg	p.R352W	CNTROB_ENST00000565740.1_Missense_Mutation_p.R352W|CNTROB_ENST00000563694.1_Missense_Mutation_p.R352W|CNTROB_ENST00000380255.3_Missense_Mutation_p.R352W	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	352					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GGAGACTCTTCGGGCTGCCCT	0.612000													18	62					0	0	0.004990	0	0
IKBKE	9641	broad.mit.edu	37	1	206649530	206649530	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:206649530G>A	ENST00000367120.3	+	6	738	c.365G>A	c.(364-366)gGc>gAc	p.G122D	IKBKE_ENST00000462698.1_Intron|IKBKE_ENST00000537984.1_Missense_Mutation_p.G37D	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	122	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding	p.G122D(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					CCAGTGGCCGGCATGAACCAC	0.617000													3	39					0	0	0.004672	0	0
OPCML	4978	broad.mit.edu	37	11	132527154	132527154	+	Silent	SNP	G	G	A	rs142071206	byFrequency	TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:132527154G>A	ENST00000331898.7	-	2	806	c.228C>T	c.(226-228)taC>taT	p.Y76Y	OPCML_ENST00000541867.1_Silent_p.Y76Y|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000524381.1_Silent_p.Y69Y|OPCML_ENST00000374778.4_Silent_p.Y35Y	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	76	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CATTCCCAGCGTAGAGGATGG	0.542000													12	71					0	0	0.001855	0	0
ZNF471	57573	broad.mit.edu	37	19	57037304	57037304	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57037304G>C	ENST00000308031.5	+	5	2001	c.1868G>C	c.(1867-1869)gGa>gCa	p.G623A	ZNF471_ENST00000591537.1_3'UTR|ZNF471_ENST00000593197.1_3'UTR	NM_020813.2	NP_065864.2	Q9BX82	ZN471_HUMAN	zinc finger protein 471	623					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGTCATACTGGAGAAGAACCT	0.403000													9	45					0	0	0.008291	0	0
ZNF789	285989	broad.mit.edu	37	7	99074083	99074083	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:99074083T>G	ENST00000331410.5	+	2	274	c.4T>G	c.(4-6)Ttc>Gtc	p.F2V	ZNF789_ENST00000379724.3_Missense_Mutation_p.F2V|ZNF789_ENST00000493485.1_5'UTR|ZNF789_ENST00000448667.1_5'UTR|ZNF789_ENST00000483089.1_5'UTR	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAAGCCATGTTCCCACCAGC	0.562000													7	52					0	0	0.003080	0	0
MDGA2	161357	broad.mit.edu	37	14	47351384	47351384	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:47351384T>C	ENST00000426342.1	-	11	2131	c.1385A>G	c.(1384-1386)aAt>aGt	p.N462S	MDGA2_ENST00000439988.2_Missense_Mutation_p.N691S|MDGA2_ENST00000399232.2_Missense_Mutation_p.N760S|MDGA2_ENST00000357362.3_Missense_Mutation_p.N462S|MDGA2_ENST00000399222.3_5'UTR	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	691	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						AATATTCCCATTTATTTTAAT	0.373000													3	23					0	0	0.004672	0	0
TRPC6	7225	broad.mit.edu	37	11	101323814	101323814	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:101323814C>G	ENST00000344327.3	-	13	3092	c.2668G>C	c.(2668-2670)Gac>Cac	p.D890H	TRPC6_ENST00000360497.4_Missense_Mutation_p.D835H|TRPC6_ENST00000348423.4_Missense_Mutation_p.D774H|TRPC6_ENST00000532133.1_Missense_Mutation_p.D812H	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	890					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTTGAGATGTCCTGCTTAATT	0.398000													8	61					0	0	0.004482	0	0
PEX11A	8800	broad.mit.edu	37	15	90226612	90226612	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:90226612C>T	ENST00000300056.3	-	3	889	c.740G>A	c.(739-741)cGt>cAt	p.R247H	PEX11A_ENST00000561257.1_Missense_Mutation_p.R216H|PEX11A_ENST00000561224.1_Intron|PEX11A_ENST00000557982.1_Intron|PEX11A_ENST00000559170.1_3'UTR	NM_001271573.1	NP_001258502.1	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	247					cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane				endometrium(2)|large_intestine(2)|lung(3)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			AACACCCTAACGGGTCTTCAG	0.443000													62	207					0	0	0.014410	0	0
MYBPC1	4604	broad.mit.edu	37	12	102028349	102028349	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:102028349C>T	ENST00000549145.1	+	8	638	c.538C>T	c.(538-540)Cca>Tca	p.P180S	MYBPC1_ENST00000547509.1_Missense_Mutation_p.P153S|MYBPC1_ENST00000545503.2_Missense_Mutation_p.P167S|MYBPC1_ENST00000541119.1_Missense_Mutation_p.P155S|MYBPC1_ENST00000536007.1_Missense_Mutation_p.P167S|MYBPC1_ENST00000452455.2_Missense_Mutation_p.P167S|MYBPC1_ENST00000441232.1_Missense_Mutation_p.P167S|MYBPC1_ENST00000392934.3_Missense_Mutation_p.P154S|MYBPC1_ENST00000361466.2_Missense_Mutation_p.P192S|MYBPC1_ENST00000547405.1_Missense_Mutation_p.P141S|MYBPC1_ENST00000361685.2_Missense_Mutation_p.P192S|MYBPC1_ENST00000553190.1_Missense_Mutation_p.P167S|MYBPC1_ENST00000360610.2_Missense_Mutation_p.P167S|MYBPC1_ENST00000551300.1_Missense_Mutation_p.P68S|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000550270.1_Missense_Mutation_p.P167S			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	167					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TGGGACTACTCCAAACATTGA	0.358000													4	46					0	0	0.009096	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													4	6	---	---	---	---					
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:147560457_147560458insGGC	ENST00000281321.3	+	1	413_414	c.165_166insGGC	c.(163-168)gggcgg>ggGGCgcgg	p.55_56GR>GAR	AC093887.1_ENST00000584185.1_RNA	NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	55	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.762													8	16	---	---	---	---					
FRG2B	441581	broad.mit.edu	37	10	135438960	135438960	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr10:135438960delC	ENST00000443774.1	-	4	532	c.483delG	c.(481-483)agfs	p.R161fs	FRG2B_ENST00000425520.1_Frame_Shift_Del_p.R160fs			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	160						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGGCCCGAGACCTATGCCGCT	0.557													7	250	---	---	---	---					
ACTN3	89	broad.mit.edu	37	11	66325699	66325699	+	RNA	DEL	T	T	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:66325699delT	ENST00000513398.1	+	0	1373				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						GAGATTGGTGTGCAGGGGCAG	0.587													7	46	---	---	---	---					
GOLGA2P5	55592	broad.mit.edu	37	12	100564316	100564316	+	RNA	DEL	G	G	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:100564316delG	ENST00000397112.4	-	0	599					NR_036632.1															large_intestine(1)|lung(3)	4						CAGGCTGCCAGGGGATGGGGC	0.587													2	4	---	---	---	---					
FAM155A	728215	broad.mit.edu	37	13	108518337	108518338	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:108518337_108518338insC	ENST00000375915.2	-	1	745_746	c.607_608insG	c.(607-609)cggfs	p.R203fs		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	203						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTCCTGCCCGTCCCCCCCGGCC	0.609													26	143	---	---	---	---					
ATP6V0D1	9114	broad.mit.edu	37	16	67472541	67472543	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67472541_67472543delAGA	ENST00000290949.3	-	8	1094_1096	c.944_946delTCT	c.(943-948)tat>t	p.FY315del	ATP6V0D1_ENST00000540149.1_In_Frame_Del_p.FY356del|ATP6V0D1_ENST00000602876.1_In_Frame_Del_p.FY238del|ATP6V0D1_ENST00000567694.1_5'UTR	NM_004691.4	NP_004682.2	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	315					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex				large_intestine(3)|lung(3)|urinary_tract(2)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		ACGAAGGCATAGAAGACACCAAA	0.552													13	105	---	---	---	---					
