Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRAV14DV4	28669	broad.mit.edu	37	14	22392815	22392815	+	RNA	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr14:22392815C>T	ENST00000390440.2	+	0	413																											TATTTCTGTGCAATGAGAGAG	0.522000													34	40					0	0	0.080422	0	0
MUC17	140453	broad.mit.edu	37	7	100677648	100677648	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:100677648C>A	ENST00000306151.4	+	3	3015	c.2951C>A	c.(2950-2952)cCa>cAa	p.P984Q		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	984	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAACGACTCCATTAACAAGC	0.507000													92	160					1.01459e-35	1.28316e-35	0.139131	1	0
ABCA1	19	broad.mit.edu	37	9	107593339	107593339	+	Missense_Mutation	SNP	G	G	A	rs2853574		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:107593339G>A	ENST00000374736.3	-	14	2153	c.1759C>T	c.(1759-1761)Cgg>Tgg	p.R587W		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	587			R -> W (in HDLD1; dbSNP:rs2853574).		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGACGTACCGCATGTCCTCA	0.502000													4	94					0	0	0.009096	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994302	140994302	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:140994302C>T	ENST00000285879.4	+	4	1398	c.1112C>T	c.(1111-1113)tCt>tTt	p.S371F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	371							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCCCAGTCTCCTCTCCAG	0.478000										HNSCC(15;0.026)			22	72					0	0	0.062417	0	0
SCG3	29106	broad.mit.edu	37	15	51981445	51981445	+	Silent	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:51981445A>G	ENST00000220478.3	+	6	973	c.570A>G	c.(568-570)gaA>gaG	p.E190E	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	190					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		ATACACTGGAAGATGAAGTAG	0.368000													25	43					0	0	0.076483	0	0
ZNF292	23036	broad.mit.edu	37	6	87968193	87968193	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:87968193A>G	ENST00000369577.3	+	8	4889	c.4846A>G	c.(4846-4848)Aga>Gga	p.R1616G	ZNF292_ENST00000339907.4_Missense_Mutation_p.R1611G	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TCAGAACACAAGATCCAGTCA	0.393000													7	21					0	0	0.029380	0	0
FABP4	2167	broad.mit.edu	37	8	82392828	82392828	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:82392828C>G	ENST00000256104.4	-	2	174	c.79G>C	c.(79-81)Ggc>Cgc	p.G27R	FABP4_ENST00000518669.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_001442.2	NP_001433.1	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	27					triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity	p.G27S(1)		breast(2)|central_nervous_system(1)|large_intestine(1)|ovary(1)|skin(1)	6			Epithelial(68;0.213)			GTGGCAAAGCCCACTCCTACA	0.423000													3	54					0	0	0.115264	0	0
CSMD3	114788	broad.mit.edu	37	8	113933928	113933928	+	Missense_Mutation	SNP	C	C	T	rs140758499		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:113933928C>T	ENST00000297405.5	-	10	1805	c.1561G>A	c.(1561-1563)Gca>Aca	p.A521T	CSMD3_ENST00000455883.2_Missense_Mutation_p.A417T|CSMD3_ENST00000343508.3_Missense_Mutation_p.A481T|CSMD3_ENST00000352409.3_Missense_Mutation_p.A521T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	521	Sushi 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATGCTCTTTGCGCCCTGTAGG	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	53					0	0	0.064281	0	0
SACM1L	22908	broad.mit.edu	37	3	45776796	45776796	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:45776796G>A	ENST00000389061.5	+	14	1374	c.1170G>A	c.(1168-1170)atG>atA	p.M390I	SACM1L_ENST00000418611.1_Missense_Mutation_p.M287I|SACM1L_ENST00000541314.1_Missense_Mutation_p.M329I	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	390	SAC.					Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GCAATTGCATGGATTGTCTAG	0.408000													19	53					0	0	0.049695	0	0
TMEFF2	23671	broad.mit.edu	37	2	192922459	192922459	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:192922459G>A	ENST00000392314.1	-	5	873	c.482C>T	c.(481-483)aCc>aTc	p.T161I	TMEFF2_ENST00000272771.5_Missense_Mutation_p.T161I			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	161						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AATATCACAGGTGGATGTCTC	0.378000													26	50					0	0	0.144211	0	0
CHRNA2	1135	broad.mit.edu	37	8	27327422	27327422	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:27327422C>T	ENST00000407991.1	-	3	758	c.150G>A	c.(148-150)ccG>ccA	p.P50P	CHRNA2_ENST00000240132.2_Silent_p.P50P|CHRNA2_ENST00000520933.2_Silent_p.P50P	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	50						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCCTCCCTGCGGCAATGCCG	0.637000													5	84					0	0	0.014758	0	0
RYR1	6261	broad.mit.edu	37	19	38979817	38979817	+	Splice_Site	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:38979817G>A	ENST00000355481.4	+	35	5679	c.5547_splice	c.e35-1	p.V1850_splice	RYR1_ENST00000360985.3_Splice_Site_p.V1850_splice|RYR1_ENST00000359596.3_Splice_Site_p.V1850_splice	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1850	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGTCCTGTAGGTGATGGGCAT	0.532000													11	9					0	0	0.105934	0	0
RPS6KB2	6199	broad.mit.edu	37	11	67200832	67200832	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:67200832C>T	ENST00000312629.5	+	10	865	c.820C>T	c.(820-822)Cgg>Tgg	p.R274W	AP003419.16_ENST00000535922.1_RNA	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	274	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGCAGAGAACCGGAAGAAAAC	0.632000													11	78					0	0	0.080935	0	0
MAPK11	5600	broad.mit.edu	37	22	50703752	50703752	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr22:50703752T>C	ENST00000330651.6	-	11	1113	c.1013A>G	c.(1012-1014)aAg>aGg	p.K338R		NM_002751.5	NP_002742.3	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	338					activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			breast(1)|central_nervous_system(1)|lung(4)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGCTCACCCTTCCACTCCTC	0.637000													3	63					0	0	0.115264	0	0
ZNF880	400713	broad.mit.edu	37	19	52887785	52887785	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:52887785C>T	ENST00000422689.2	+	4	967	c.952C>T	c.(952-954)Cat>Tat	p.H318Y		NM_001145434.1	NP_001138906.1	Q6PDB4	ZN880_HUMAN	zinc finger protein 880	318					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						TCAGAAAATTCATAGTGGAGA	0.413000													19	13					0	0	0.038395	0	0
DSP	1832	broad.mit.edu	37	6	7571657	7571657	+	Silent	SNP	C	C	T	rs139095230		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:7571657C>T	ENST00000379802.3	+	14	2084	c.1743C>T	c.(1741-1743)gcC>gcT	p.A581A	DSP_ENST00000418664.2_Silent_p.A581A	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	581	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGACGATAGCCGACCTTGAGT	0.443000													6	237					0	0	0.038147	0	0
TRIM2	23321	broad.mit.edu	37	4	154249705	154249705	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:154249705C>T	ENST00000338700.5	+	11	2111	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	TRIM2_ENST00000437508.2_Silent_p.F655F	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	655						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		AAGGAGAATTCATGTTGAAGT	0.343000													15	30					0	0	0.038395	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540270	169540270	+	Silent	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:169540270C>G	ENST00000340806.6	+	1	561	c.561C>G	c.(559-561)ctC>ctG	p.L187L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	187										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TCTGTGTTCTCTACACCCTGG	0.488000													4	124					0	0	0.009096	0	0
GPC3	2719	broad.mit.edu	37	X	132826430	132826430	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:132826430G>A	ENST00000370818.3	-	5	1704	c.1259C>T	c.(1258-1260)aCc>aTc	p.T420I	GPC3_ENST00000394299.2_Missense_Mutation_p.T443I|GPC3_ENST00000543339.1_Missense_Mutation_p.T366I	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	420						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					CCAGCAAAGGGTGTCGTTTTC	0.388000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				25	10					0	0	0.091800	0	0
ACTN2	88	broad.mit.edu	37	1	236924422	236924422	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:236924422C>T	ENST00000366578.4	+	20	2641	c.2475C>T	c.(2473-2475)acC>acT	p.T825T	ACTN2_ENST00000546208.1_Silent_p.T319T|ACTN2_ENST00000542672.1_Silent_p.T825T	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	825					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGCTGACACCGACACTGCCG	0.537000													27	34					0	0	0.108266	0	0
TEC	7006	broad.mit.edu	37	4	48169913	48169913	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:48169913C>T	ENST00000381501.3	-	7	710	c.553G>A	c.(553-555)Gta>Ata	p.V185I		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	185	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						TACATGGCTACAACGATTTCT	0.393000													6	97					0	0	0.029380	0	0
POLR3D	661	broad.mit.edu	37	8	22107661	22107661	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:22107661G>A	ENST00000397802.4	+	7	1210	c.995G>A	c.(994-996)cGc>cAc	p.R332H	POLR3D_ENST00000306433.4_Missense_Mutation_p.R332H			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	332					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTACTCATCCGCAAGTCTGGA	0.562000													4	56					0	0	0.009096	0	0
CELSR3	1951	broad.mit.edu	37	3	48699612	48699612	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:48699612A>T	ENST00000544264.1	-	1	736	c.456T>A	c.(454-456)agT>agA	p.S152R	CELSR3_ENST00000164024.4_Missense_Mutation_p.S152R			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	152					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGTGACAGACTACCTCTTT	0.627000													45	85					0	0	0.124865	0	0
UTRN	7402	broad.mit.edu	37	6	145093097	145093097	+	Silent	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:145093097A>G	ENST00000367545.3	+	58	8550	c.8550A>G	c.(8548-8550)caA>caG	p.Q2850Q	UTRN_ENST00000367526.4_Silent_p.Q405Q	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2850	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AACTCTTTCAATCCCTTGGTA	0.269000													17	44					0	0	0.038395	0	0
CXorf22	170063	broad.mit.edu	37	X	35938046	35938046	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:35938046C>T	ENST00000297866.5	+	1	196	c.130C>T	c.(130-132)Ccg>Tcg	p.P44S		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	44										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GCGGGTGATCCCGGCTGAGGT	0.562000													5	5					0	0	0.021553	0	0
IGFN1	91156	broad.mit.edu	37	1	201185880	201185880	+	Splice_Site	SNP	G	G	A	rs35601315		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:201185880G>A	ENST00000335211.4	+	16	9724	c.9595_splice	c.e16+1	p.E3198_splice	IGFN1_ENST00000295591.8_Splice_Site_p.E358_splice	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1									p.E3198D(1)|p.E358D(1)		autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGGCTCCTGAGGGTGAGAGAA	0.647000													28	37					0	0	0.099896	0	0
PPP1R42	286187	broad.mit.edu	37	8	67929968	67929968	+	Silent	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:67929968G>T	ENST00000522909.1	-	2	199	c.15C>A	c.(13-15)acC>acA	p.T5T	PPP1R42_ENST00000517834.1_5'UTR|PPP1R42_ENST00000324682.5_Silent_p.T5T			Q7Z4L9	LRC67_HUMAN	protein phosphatase 1, regulatory subunit 42	5																	TTAGATCCAAGGTCAGTCGAA	0.338000													14	56					0.000219431	0.000262099	0.119110	1	0
UAP1L1	91373	broad.mit.edu	37	9	139974547	139974547	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:139974547C>T	ENST00000409858.3	+	6	1163	c.1131C>T	c.(1129-1131)aaC>aaT	p.N377N	UAP1L1_ENST00000360271.3_Silent_p.N254N	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	377							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		TAAAACCGAACGGGATAAAGA	0.473000													51	59					0	0	0.139131	0	0
MUC16	94025	broad.mit.edu	37	19	9088749	9088749	+	Silent	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:9088749G>C	ENST00000397910.4	-	1	3269	c.3066C>G	c.(3064-3066)ctC>ctG	p.L1022L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1022	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCTGTTGTGAGGATGGTTG	0.473000													9	144					0	0	0.047766	0	0
AHDC1	27245	broad.mit.edu	37	1	27874105	27874105	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:27874105G>C	ENST00000374011.2	-	6	5490	c.4522C>G	c.(4522-4524)Cca>Gca	p.P1508A	AHDC1_ENST00000247087.5_Missense_Mutation_p.P1508A|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1508							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTGGCTGGTGGGCTAGCCAGG	0.711000													3	8					0	0	0.009096	0	0
CUX2	23316	broad.mit.edu	37	12	111652070	111652070	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr12:111652070C>A	ENST00000261726.6	+	2	284	c.130C>A	c.(130-132)Cat>Aat	p.H44N		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TTCTCATAAACATTTAATTGA	0.383000													4	101					0.00024832	0.000288588	0.009096	1	0
STIM2	57620	broad.mit.edu	37	4	27003875	27003875	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:27003875C>T	ENST00000382009.3	+	6	1190	c.923C>T	c.(922-924)aCa>aTa	p.T308I	STIM2_ENST00000465503.1_Missense_Mutation_p.T221I|STIM2_ENST00000467011.1_Missense_Mutation_p.T221I|STIM2_ENST00000412829.2_Missense_Mutation_p.T308I|STIM2_ENST00000467087.1_Missense_Mutation_p.T221I|STIM2_ENST00000237364.5_Missense_Mutation_p.T308I	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	221				R -> G (in Ref. 4; AAH57231).	activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				TTTATCCTCACAGTTTCTATA	0.343000													3	37					0	0	0.115264	0	0
ZNF214	7761	broad.mit.edu	37	11	7022503	7022503	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:7022503C>A	ENST00000278314.4	-	3	726	c.411G>T	c.(409-411)atG>atT	p.M137I	ZNF214_ENST00000536068.1_Missense_Mutation_p.M137I	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		ACTGCCAAGGCATAAAATTTT	0.393000													5	180					0.014758	0.0154779	0.014758	1	0
METTL13	51603	broad.mit.edu	37	1	171756952	171756952	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:171756952C>A	ENST00000361735.3	+	4	1457	c.1191C>A	c.(1189-1191)gaC>gaA	p.D397E	METTL13_ENST00000367737.5_Missense_Mutation_p.D241E|METTL13_ENST00000458517.1_Missense_Mutation_p.D396E|METTL13_ENST00000362019.3_Missense_Mutation_p.D311E	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	397							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TGAGCGGTGACTATGTCATTG	0.552000													3	33					0.004672	0.00508597	0.115264	1	0
GPIHBP1	338328	broad.mit.edu	37	8	144295190	144295190	+	Silent	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:144295190G>T	ENST00000330824.2	+	1	123	c.48G>T	c.(46-48)cgG>cgT	p.R16R		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	16					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTGCGGGCGGCCAGGTGCGG	0.672000													3	23					0.00909568	0.00965714	0.009096	1	0
SMARCA5	8467	broad.mit.edu	37	4	144467996	144467996	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:144467996A>G	ENST00000283131.3	+	20	3050	c.2588A>G	c.(2587-2589)gAt>gGt	p.D863G		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	863	SANT 1.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					TGGGGTCGTGATGATATTGAA	0.338000													15	31					0	0	0.132662	0	0
TAF1	6872	broad.mit.edu	37	X	70613166	70613166	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:70613166C>T	ENST00000449580.1	+	21	3115	c.3064C>T	c.(3064-3066)Cgc>Tgc	p.R1022C	TAF1_ENST00000423759.1_Missense_Mutation_p.R1043C|TAF1_ENST00000373790.4_Missense_Mutation_p.R1022C|TAF1_ENST00000276072.3_Missense_Mutation_p.R1043C			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1022					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity	p.R1022G(1)		breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				AAAGTTGTCCCGCTGGGAAGT	0.443000													24	12					0	0	0.116897	0	0
CELSR3	1951	broad.mit.edu	37	3	48699613	48699613	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:48699613C>T	ENST00000544264.1	-	1	735	c.455G>A	c.(454-456)aGt>aAt	p.S152N	CELSR3_ENST00000164024.4_Missense_Mutation_p.S152N			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	152					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGTGACAGACTACCTCTTTG	0.632000													47	84					0	0	0.139131	0	0
OR4C11	219429	broad.mit.edu	37	11	55371281	55371281	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:55371281G>A	ENST00000302231.4	-	1	593	c.569C>T	c.(568-570)aCt>aTt	p.T190I		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GATCATGTAAGTGTCCATGCA	0.398000													60	46					0	0	0.139131	0	0
CILP2	148113	broad.mit.edu	37	19	19654666	19654666	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654666T>G	ENST00000586018.1	+	8	1432	c.1330T>G	c.(1330-1332)Tgc>Ggc	p.C444G	CILP2_ENST00000291495.4_Missense_Mutation_p.C438G			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	438						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CTCCCGCTGCTGCTCTGTGCG	0.682000													33	39					0	0	0.045705	0	0
AXDND1	126859	broad.mit.edu	37	1	179460728	179460728	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:179460728T>G	ENST00000367618.3	+	19	2534	c.2147T>G	c.(2146-2148)aTg>aGg	p.M716R	AXDND1_ENST00000457238.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	716										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						CTGATTTTAATGATACCCAAC	0.363000													29	57					0	0	0.134883	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45716536	45716536	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:45716536G>A	ENST00000413988.1	-	10	1061	c.1021C>T	c.(1021-1023)Cgg>Tgg	p.R341W	EXOC3L2_ENST00000252482.3_Missense_Mutation_p.R341W|AC006126.3_ENST00000591569.1_Intron	NM_138568.3	NP_612635.3	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	341								p.R341W(1)		endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		TCCAGGTCCCGGGCCACGGCC	0.657000													9	24					0	0	0.080935	0	0
PRKG1	5592	broad.mit.edu	37	10	53564372	53564372	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:53564372T>A	ENST00000373980.4	+	4	1037	c.620T>A	c.(619-621)aTt>aAt	p.I207N	PRKG1_ENST00000373985.1_Missense_Mutation_p.I180N|PRKG1_ENST00000401604.2_Missense_Mutation_p.I192N	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	192					actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTCTGGGCCATTGATCGACAA	0.343000													12	36					0	0	0.105934	0	0
IP6K3	117283	broad.mit.edu	37	6	33690555	33690555	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:33690555T>C	ENST00000451316.1	-	7	1710	c.1175A>G	c.(1174-1176)tAt>tGt	p.Y392C	IP6K3_ENST00000293756.4_Missense_Mutation_p.Y392C	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	392					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						GCCAAAAATATAGCCAGGGTC	0.483000													29	82					0	0	0.144211	0	0
CES2	8824	broad.mit.edu	37	16	66974469	66974469	+	Silent	SNP	G	G	A	rs150055059		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:66974469G>A	ENST00000317091.4	+	5	1863	c.879G>A	c.(877-879)gcG>gcA	p.A293A	CES2_ENST00000417689.1_Silent_p.A293A	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	229					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		GCGAGTCTGCGGGTGGCACGA	0.607000													35	70					0	0	0.098360	0	0
KIF3B	9371	broad.mit.edu	37	20	30897975	30897975	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr20:30897975G>T	ENST00000375712.3	+	2	562	c.395G>T	c.(394-396)cGa>cTa	p.R132L		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	132	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACATCTCTCGATCCCAGAAT	0.463000													5	102					1.6384e-10	2.01289e-10	0.029380	1	0
ASAP2	8853	broad.mit.edu	37	2	9515038	9515038	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:9515038G>A	ENST00000281419.3	+	17	2051	c.1711G>A	c.(1711-1713)Gat>Aat	p.D571N	ASAP2_ENST00000315273.4_Missense_Mutation_p.D571N	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	571					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						TGATGGTGTGGATCTTACGGA	0.483000													23	39					0	0	0.076483	0	0
ELL	8178	broad.mit.edu	37	19	18555654	18555654	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:18555654T>A	ENST00000262809.4	-	12	1845	c.1774A>T	c.(1774-1776)Aag>Tag	p.K592*		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	592					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CAGCGGTGCTTCTCCTGGCTG	0.642000			T	MLL	AL								16	41					0	0	0.146539	0	0
LINC00969	440993	broad.mit.edu	37	3	195395399	195395399	+	RNA	SNP	G	G	A	rs62287990	by1000genomes	TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:195395399G>A	ENST00000445430.1	+	0	806																											GGCTACGGGCGCACCTACTTG	0.607000													5	49					0	0	0.021553	0	0
GFRA1	2674	broad.mit.edu	37	10	117823944	117823944	+	Silent	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:117823944G>A	ENST00000439649.3	-	10	1715	c.1348C>T	c.(1348-1350)Ctg>Ttg	p.L450L	GFRA1_ENST00000369236.1_Silent_p.L450L|GFRA1_ENST00000355422.6_Silent_p.L455L|GFRA1_ENST00000544592.1_Silent_p.L334L	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	455					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		AGGGTGGACAGAGCGGTTACC	0.428000													12	36					0	0	0.080935	0	0
PDGFRL	5157	broad.mit.edu	37	8	17478590	17478590	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:17478590G>T	ENST00000541323.1	+	4	829	c.384G>T	c.(382-384)ttG>ttT	p.L128F	PDGFRL_ENST00000398074.3_Missense_Mutation_p.L128F|PDGFRL_ENST00000251630.6_Missense_Mutation_p.L128F	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	128	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		ACGGCCAGTTGACTCTGGTCA	0.567000													13	35					1.05317e-09	1.27567e-09	0.119110	1	0
ZNF609	23060	broad.mit.edu	37	15	64967739	64967739	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:64967739G>A	ENST00000326648.3	+	4	2814	c.2686G>A	c.(2686-2688)Gag>Aag	p.E896K		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	896						nucleus	zinc ion binding	p.E896Q(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCAAGGCTTTGAGAGTTACTA	0.507000													5	97					0	0	0.021553	0	0
ANKRD17	26057	broad.mit.edu	37	4	73963791	73963791	+	Splice_Site	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:73963791T>G	ENST00000358602.4	-	26	5136	c.5021_splice	c.e26+1	p.K1674_splice	ANKRD17_ENST00000330838.6_Splice_Site_p.K1423_splice|ANKRD17_ENST00000509867.2_Splice_Site_p.K1561_splice	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	1674	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGAACTAACTTTATTGAAGCC	0.333000													28	50					0	0	0.045705	0	0
OR2A14	135941	broad.mit.edu	37	7	143826964	143826964	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:143826964C>T	ENST00000408899.2	+	1	814	c.759C>T	c.(757-759)agC>agT	p.S253S		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					TCTTTGGCAGCGCCATTGTCA	0.577000													4	136					0	0	0.009096	0	0
SYBU	55638	broad.mit.edu	37	8	110587412	110587412	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:110587412C>T	ENST00000399066.3	-	6	2433	c.1706G>A	c.(1705-1707)cGc>cAc	p.R569H	SYBU_ENST00000528331.1_Missense_Mutation_p.R453H|SYBU_ENST00000422135.1_Missense_Mutation_p.R572H|SYBU_ENST00000533895.1_Missense_Mutation_p.R571H|SYBU_ENST00000529175.1_Missense_Mutation_p.R366H|SYBU_ENST00000424158.2_Missense_Mutation_p.R577H|SYBU_ENST00000408908.2_Missense_Mutation_p.R572H|SYBU_ENST00000533171.1_Missense_Mutation_p.R572H|SYBU_ENST00000446070.2_Missense_Mutation_p.R571H|SYBU_ENST00000276646.9_Missense_Mutation_p.R572H|SYBU_ENST00000529690.1_Missense_Mutation_p.R442H|SYBU_ENST00000532779.1_Missense_Mutation_p.R504H|SYBU_ENST00000408889.3_Missense_Mutation_p.R453H|SYBU_ENST00000440310.1_Missense_Mutation_p.R572H|SYBU_ENST00000533065.1_Missense_Mutation_p.R453H|SYBU_ENST00000528647.1_Missense_Mutation_p.R571H|SYBU_ENST00000419099.1_Missense_Mutation_p.R571H|SYBU_ENST00000433638.1_Missense_Mutation_p.R572H	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	572						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						TCTCATGAGGCGGTTTGCATG	0.542000													19	37					0	0	0.049695	0	0
GNRHR	2798	broad.mit.edu	37	4	68610290	68610290	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:68610290G>A	ENST00000420975.2	-	2	609	c.610C>T	c.(610-612)Cca>Tca	p.P204S	GNRHR_ENST00000226413.4_Silent_p.P246P|RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000502758.1_RNA	NM_001012763.1	NP_001012781.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	0					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ACATACCGTGGGGGTCCTGAT	0.428000													20	26					0	0	0.049695	0	0
ARID1B	57492	broad.mit.edu	37	6	157502235	157502235	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:157502235C>G	ENST00000346085.5	+	12	3269	c.3268C>G	c.(3268-3270)Ctg>Gtg	p.L1090V	ARID1B_ENST00000350026.5_Missense_Mutation_p.L1077V|ARID1B_ENST00000478761.1_3'UTR|ARID1B_ENST00000367148.1_Missense_Mutation_p.L1130V|ARID1B_ENST00000275248.4_Missense_Mutation_p.L1072V	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1077	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGTCTCAAGTCTGCCTGCCGT	0.577000													7	21					0	0	0.029380	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29432467	29432467	+	Splice_Site	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr18:29432467G>A	ENST00000283351.4	-	24	3838	c.3502_splice	c.e24-1	p.A1168_splice	TRAPPC8_ENST00000582539.1_Splice_Site_p.A1114_splice	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	1168					ER to Golgi vesicle-mediated transport	cis-Golgi network		p.A1168V(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTGTGTGGCCGCTAAAAAACA	0.318000													4	186					0	0	0.009096	0	0
CDH11	1009	broad.mit.edu	37	16	64984710	64984710	+	Silent	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:64984710G>A	ENST00000394156.3	-	12	2307	c.1854C>T	c.(1852-1854)ggC>ggT	p.G618G	CDH11_ENST00000566827.1_Silent_p.G492G|CDH11_ENST00000268603.4_Silent_p.G618G			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	618					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CGATCAGGGCGCCTGTGCTCA	0.632000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	27					0	0	0.058154	0	0
ZNF608	57507	broad.mit.edu	37	5	123977043	123977043	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:123977043C>T	ENST00000306315.5	-	7	4787	c.4352G>A	c.(4351-4353)cGc>cAc	p.R1451H	ZNF608_ENST00000504926.1_Missense_Mutation_p.R1024H|ZNF608_ENST00000513985.1_5'UTR	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1451						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGGGGAGTGGCGATCCCTTTC	0.557000													4	76					0	0	0.009096	0	0
ZNF658	26149	broad.mit.edu	37	9	40774007	40774007	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:40774007G>T	ENST00000602553.1	-	5	1562	c.1268C>A	c.(1267-1269)tCa>tAa	p.S423*	ZNF658_ENST00000377626.3_Nonsense_Mutation_p.S423*|ZNF658_ENST00000441795.1_Nonsense_Mutation_p.S421*			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATGTGAACTTGAACAAAAGGA	0.398000													6	181					0.00116845	0.00132219	0.021553	1	0
APOA1BP	128240	broad.mit.edu	37	1	156563322	156563322	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:156563322C>T	ENST00000368234.3	+	5	626	c.583C>T	c.(583-585)Cat>Tat	p.H195Y	APOA1BP_ENST00000368233.3_Silent_p.P213P|APOA1BP_ENST00000368235.3_Silent_p.P213P			Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein	0	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCACTGTGCCCATTGCCAGCA	0.577000													5	46					0	0	0.014758	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788902	140788902	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:140788902G>C	ENST00000520790.1	+	1	1133	c.1133G>C	c.(1132-1134)gGa>gCa	p.G378A	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTTCGGAGGAAATGGAGAA	0.413000													19	21					0	0	0.055883	0	0
ZNF835	90485	broad.mit.edu	37	19	57176313	57176313	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:57176313G>A	ENST00000537055.2	-	2	485	c.254C>T	c.(253-255)gCg>gTg	p.A85V		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.A107V(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CTCCCCAGGCGCGCTGCACCT	0.647000													10	17					0	0	0.146539	0	0
GCDH	2639	broad.mit.edu	37	19	13004312	13004312	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:13004312G>A	ENST00000222214.5	+	6	561	c.350G>A	c.(349-351)gGg>gAg	p.G117E	GCDH_ENST00000591470.1_Missense_Mutation_p.G117E|GCDH_ENST00000422947.2_Missense_Mutation_p.G73E|GCDH_ENST00000457854.1_Missense_Mutation_p.G117E			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	117					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						GGCTGTGCTGGGGTTTCGTCT	0.597000													25	27					0	0	0.108266	0	0
FRK	2444	broad.mit.edu	37	6	116288718	116288718	+	Silent	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:116288718T>C	ENST00000606080.1	-	4	1241	c.795A>G	c.(793-795)aaA>aaG	p.K265K	FRK_ENST00000538210.1_Silent_p.K123K	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	265	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TCGCACCTGGTTTTAATGTTT	0.403000													9	126					0	0	0.058154	0	0
NMUR2	56923	broad.mit.edu	37	5	151784417	151784417	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:151784417G>T	ENST00000255262.3	-	1	423	c.258C>A	c.(256-258)agC>agA	p.S86R	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	86					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGACCGCCAGGCTGAAGAGGT	0.572000													30	68					1.99505e-19	2.48659e-19	0.050027	1	0
KIAA1009	22832	broad.mit.edu	37	6	84862866	84862866	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:84862866C>A	ENST00000403245.3	-	23	3141	c.3027G>T	c.(3025-3027)gaG>gaT	p.E1009D	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Missense_Mutation_p.E933D	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	1009					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CAAGTAGCTGCTCCTGCTGCT	0.428000													5	14					0.00116845	0.00132219	0.021553	1	0
LRIF1	55791	broad.mit.edu	37	1	111490996	111490996	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:111490996G>A	ENST00000369763.4	-	4	2285	c.1895C>T	c.(1894-1896)gCa>gTa	p.A632V	LRIF1_ENST00000494675.1_Missense_Mutation_p.A96V|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000485275.2_Missense_Mutation_p.A96V	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						ATTAGTTTTTGCTTTTCTTTT	0.343000													11	22					0	0	0.069234	0	0
ATXN1	6310	broad.mit.edu	37	6	16327903	16327904	+	In_Frame_Ins	INS	-	-	TGA	rs3817753		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:16327903_16327904insTGA	ENST00000244769.4	-	8	1574_1575	c.638_639insTCA	c.(637-639)cca>cTCAca	p.213_213P>LT	ATXN1_ENST00000436367.1_In_Frame_Ins_p.213_213P>LT	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	213	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgctgctgctgctgatgctg	0.668													4	2	---	---	---	---					
TDRD7	23424	broad.mit.edu	37	9	100222899	100222899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:100222899delA	ENST00000355295.4	+	7	1590	c.1295delA	c.(1294-1296)cafs	p.Q432fs	TDRD7_ENST00000422139.2_Frame_Shift_Del_p.Q358fs	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	432	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				ATGGTTGAACAAGAGTATTTG	0.408													27	91	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651228	+	In_Frame_Del	DEL	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	-	rs35089393	by1000genomes	TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:1651199_1651228delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	ENST00000399676.2	+	1	167_196	c.129_158delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	c.(127-159)ggg>gg	p.GGCGGCGSGCA43del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtgggggctgtggctccggctgtgcgggctgtggg	0.691													47	10	---	---	---	---					
OVOS2	144203	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													4	9	---	---	---	---					
UNC79	57578	broad.mit.edu	37	14	94046720	94046721	+	Splice_Site	DEL	GT	GT	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr14:94046720_94046721delGT	ENST00000553484.1	+	19	2813_2814	c.2661_splice	c.e19+1	p.V887_splice	UNC79_ENST00000555664.1_Splice_Site_p.V887_splice|UNC79_ENST00000256339.4_Splice_Site_p.V710_splice|UNC79_ENST00000393151.2_Splice_Site_p.V887_splice			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	887						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AAGCCGGCTGGTGGTAAGCAGT	0.441													13	34	---	---	---	---					
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:22382920_22382921insT	ENST00000328795.4	+	1	539_540	c.448_449insT	c.(448-450)tggfs	p.W150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535													20	113	---	---	---	---					
ZNF646	9726	broad.mit.edu	37	16	31092942	31092943	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:31092942_31092943insC	ENST00000394979.2	+	1	5720_5721	c.5297_5298insC	c.(5296-5298)tccfs	p.S1766fs	ZNF646_ENST00000300850.5_Frame_Shift_Ins_p.S1766fs			O15015	ZN646_HUMAN	zinc finger protein 646	1766					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						TGCCCCCATTGTCCCCGCCACT	0.693													7	64	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45247389	45247389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr17:45247389delT	ENST00000066544.3	-	4	364	c.271delA	c.(271-273)tcfs	p.I91fs	CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000531206.1_Frame_Shift_Del_p.I91fs|RP5-867C24.5_ENST00000572193.1_RNA|CDC27_ENST00000446365.2_Frame_Shift_Del_p.I30fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.I91fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	91					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.I91fs*54(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CCAGATAAGATTTGTTCCCCT	0.323													7	113	---	---	---	---					
KCNH6	81033	broad.mit.edu	37	17	61601637	61601645	+	In_Frame_Del	DEL	CCCAACACA	CCCAACACA	-	rs143633824		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr17:61601637_61601645delCCCAACACA	ENST00000583023.1	+	2	225_233	c.214_222delCCCAACACA	c.(214-222)del	p.PNT72del	KCNH6_ENST00000456941.2_In_Frame_Del_p.PNT72del|KCNH6_ENST00000314672.5_In_Frame_Del_p.PNT72del|KCNH6_ENST00000581784.1_In_Frame_Del_p.PNT72del|KCNH6_ENST00000580652.1_In_Frame_Del_p.PNT72del	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	72					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CCTCACAGGCCCCAACACACCAAGCAGCG	0.612													24	83	---	---	---	---					
CILP2	148113	broad.mit.edu	37	19	19654650	19654659	+	Frame_Shift_Del	DEL	CGCCAGCTCC	CGCCAGCTCC	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654650_19654659delCGCCAGCTCC	ENST00000586018.1	+	8	1416_1425	c.1314_1323delCGCCAGCTCC	c.(1312-1323)gafs	p.DASS438fs	CILP2_ENST00000291495.4_Frame_Shift_Del_p.DASS432fs			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	432						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity	p.A433D(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCTGCGGGGACGCCAGCTCCCGCTGCTGCT	0.671													32	59	---	---	---	---					
FCGBP	8857	broad.mit.edu	37	19	40384082	40384089	+	Frame_Shift_Del	DEL	CGTCGTAA	CGTCGTAA	-	rs143028655	byFrequency	TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:40384082_40384089delCGTCGTAA	ENST00000221347.6	-	21	9528_9535	c.9521_9528delTTACGACG	c.(9520-9528)cfs	p.LTT3174fs		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	3174	TIL 7.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ATACGGCTGGCGTCGTAAGGGGTGCAGG	0.635													9	134	---	---	---	---					
