Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LDHD	197257	broad.mit.edu	37	16	75146279	75146279	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:75146279A>G	ENST00000300051.4	-	11	1545	c.1499T>C	c.(1498-1500)cTc>cCc	p.L500P	LDHD_ENST00000450168.2_Missense_Mutation_p.L477P	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	500							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						TGGATTCATGAGGCCTTGGGG	0.622000													3	37					0	0	0.00024832	0	0
CLCN4	1183	broad.mit.edu	37	X	10201603	10201603	+	Silent	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chrX:10201603C>T	ENST00000380833.4	+	13	2653	c.2262C>T	c.(2260-2262)ccC>ccT	p.P754P	CLCN4_ENST00000421085.2_Silent_p.P660P|CLCN4_ENST00000380829.1_Silent_p.P723P	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	754	CBS 2.					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACCAGGACCCCGAATCCATCA	0.363000													4	40					0	0	0.000602214	0	0
KPNA4	3840	broad.mit.edu	37	3	160239585	160239585	+	Silent	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:160239585G>A	ENST00000334256.4	-	11	1190	c.885C>T	c.(883-885)caC>caT	p.H295H		NM_002268.4	NP_002259.1	O00629	IMA4_HUMAN	karyopherin alpha 4 (importin alpha 3)	295					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)	22			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TAACTTCCTGGTGGCTGAGCA	0.388000													53	79					0	0	0.000781405	0	0
PDYN	5173	broad.mit.edu	37	20	1961249	1961249	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:1961249T>G	ENST00000217305.2	-	4	710	c.485A>C	c.(484-486)tAt>tCt	p.Y162S	PDYN_ENST00000539905.1_Missense_Mutation_p.Y162S|PDYN_ENST00000540134.1_Missense_Mutation_p.Y162S|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	162					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTCAGCGAGATAGAGTGTGCC	0.597000													5	94					0	0	0.000602214	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23261077	23261077	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr15:23261077G>A	ENST00000450802.3	+	10	850	c.752G>A	c.(751-753)cGg>cAg	p.R251Q																								GAGAGGGCCCGGTGGCAGCAG	0.463000													40	110					0	0	0.000781405	0	0
NAALADL2	254827	broad.mit.edu	37	3	174974236	174974236	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:174974236G>A	ENST00000454872.1	+	4	984	c.856G>A	c.(856-858)Gat>Aat	p.D286N	NAALADL2-AS2_ENST00000424690.1_RNA|NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	286					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AATGGCAGATGATTTAAAAAG	0.363000													14	78					0	0	0.000219431	0	0
PLCB1	23236	broad.mit.edu	37	20	8678323	8678323	+	Silent	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:8678323C>T	ENST00000378641.3	+	11	1535	c.1060C>T	c.(1060-1062)Ctg>Ttg	p.L354L	PLCB1_ENST00000338037.6_Silent_p.L354L|PLCB1_ENST00000378637.2_Silent_p.L354L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	354	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CCAAGTGCTCCTGTCTGGTTG	0.502000													38	86					0	0	0.00111076	0	0
EP300	2033	broad.mit.edu	37	22	41565529	41565529	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr22:41565529G>A	ENST00000263253.7	+	26	5414	c.4195G>A	c.(4195-4197)Gat>Aat	p.D1399N	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1399					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399N(5)|p.D1399Y(2)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						ATCTTACCTCGATAGTGTTCA	0.338000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				32	24					0	0	0.000409698	0	0
UBR4	23352	broad.mit.edu	37	1	19451143	19451143	+	Silent	SNP	T	T	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:19451143T>G	ENST00000375267.2	-	65	9483	c.9480A>C	c.(9478-9480)ctA>ctC	p.L3160L	UBR4_ENST00000375254.3_Silent_p.L3160L|UBR4_ENST00000375217.2_Silent_p.L3153L|UBR4_ENST00000375226.2_Silent_p.L3136L			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3160					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCATTTCTGTTAGAAGCTGAG	0.423000													14	44					0	0	0.00185496	0	0
SLC30A8	169026	broad.mit.edu	37	8	118170064	118170064	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:118170064G>A	ENST00000427715.2	+	7	840	c.406G>A	c.(406-408)Gca>Aca	p.A136T	SLC30A8_ENST00000519688.1_Missense_Mutation_p.A136T|SLC30A8_ENST00000456015.2_Missense_Mutation_p.A185T|SLC30A8_ENST00000521243.1_Missense_Mutation_p.A136T	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	185					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TTCCAGCTGCGCAGTGGCGGC	0.527000													37	69					0	0	0.000953801	0	0
SLC4A4	8671	broad.mit.edu	37	4	72319250	72319250	+	Missense_Mutation	SNP	C	C	G	rs138493429	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:72319250C>G	ENST00000340595.3	+	9	1425	c.1229C>G	c.(1228-1230)gCg>gGg	p.A410G	SLC4A4_ENST00000512686.1_Missense_Mutation_p.A410G|SLC4A4_ENST00000351898.6_Missense_Mutation_p.A454G|SLC4A4_ENST00000264485.5_Missense_Mutation_p.A454G|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000425175.1_Missense_Mutation_p.A454G	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	454						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AAGAGGAAAGCGCCATTTTTT	0.343000													28	113					0	0	0.00127121	0	0
PRR23A	729627	broad.mit.edu	37	3	138724434	138724434	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:138724434A>G	ENST00000383163.2	-	1	676	c.677T>C	c.(676-678)gTc>gCc	p.V226A		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	226	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						TGAGCTGGGGACAGGCTCCAG	0.682000													6	17					0	0	8.12818e-05	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	29					0	0	6.4e-05	0	0
ACSL1	2180	broad.mit.edu	37	4	185684332	185684332	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:185684332C>T	ENST00000515030.1	-	16	1835	c.1510G>A	c.(1510-1512)Ggc>Agc	p.G504S	ACSL1_ENST00000504342.1_Missense_Mutation_p.G504S|ACSL1_ENST00000513317.1_Missense_Mutation_p.G504S|ACSL1_ENST00000454703.2_Missense_Mutation_p.G333S|ACSL1_ENST00000437665.3_Missense_Mutation_p.G333S|ACSL1_ENST00000507295.1_Missense_Mutation_p.G470S|ACSL1_ENST00000281455.2_Missense_Mutation_p.G504S			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	504					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCGCCCTCGCCCTCGGCAGCC	0.488000													10	28					0	0	0.000442599	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395831	47395831	+	Missense_Mutation	SNP	G	G	A	rs58897090		TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:47395831G>A	ENST00000310638.4	-	12	1547	c.1516C>T	c.(1516-1518)Ctc>Ttc	p.L506F	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.L507F	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	506			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AGCCTCCTGAGACGCAGGTGG	0.577000													4	59					0	0	8.12818e-05	0	0
ARSI	340075	broad.mit.edu	37	5	149676844	149676844	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr5:149676844C>A	ENST00000328668.7	-	2	2222	c.1643G>T	c.(1642-1644)tGc>tTc	p.C548F		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	548						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAAATCTTGCATTTTTTCTT	0.527000													48	84					6.61955e-31	5.68679e-30	0.000781405	1	0
GPBP1L1	60313	broad.mit.edu	37	1	46099783	46099784	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:46099783_46099784insA	ENST00000355105.3	-	9	2229_2230	c.869_870insT	c.(868-870)cagfs	p.Q290fs	GPBP1L1_ENST00000290795.3_Frame_Shift_Ins_p.Q290fs|GPBP1L1_ENST00000479235.1_5'UTR	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					TGGGAGAACTCAGAGCTGCACC	0.465													22	56	---	---	---	---					
ALK	238	broad.mit.edu	37	2	29451771	29451772	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr2:29451771_29451772delCA	ENST00000389048.3	-	16	3699_3700	c.2793_2794delTG	c.(2791-2796)gggafs	p.GG935fs	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	935	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCGCCTCCTCCACCTGAGGAGC	0.619			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				12	33	---	---	---	---					
TIMMDC1	51300	broad.mit.edu	37	3	119219666	119219667	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:119219666_119219667insAG	ENST00000494664.1	+	2	521_522	c.319_320insAG	c.(319-321)gagfs	p.E107fs	TIMMDC1_ENST00000493694.1_Intron	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	107						integral to membrane|mitochondrial inner membrane	protein transporter activity			autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						ATACATTGAGCAGAGCCAGGCA	0.421													42	66	---	---	---	---					
FSTL5	56884	broad.mit.edu	37	4	162307557	162307558	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:162307557_162307558insT	ENST00000306100.5	-	16	2321_2322	c.1885_1886insA	c.(1885-1887)tgafs	p.*629fs	FSTL5_ENST00000379164.4_Frame_Shift_Ins_p.*628fs|FSTL5_ENST00000536695.1_Frame_Shift_Ins_p.*628fs|FSTL5_ENST00000427802.2_Frame_Shift_Ins_p.*619fs|RP11-234O6.2_ENST00000508189.1_RNA	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	629						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCAAGATCAATTTTTTGTAGT	0.361													13	36	---	---	---	---					
NUGGC	389643	broad.mit.edu	37	8	27925899	27925899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:27925899delA	ENST00000413272.2	-	5	456	c.314delT	c.(313-315)tafs	p.L105fs	NUGGC_ENST00000341513.6_Frame_Shift_Del_p.L105fs	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		GCTTCCAAATAATGCAATGTA	0.433													2	4	---	---	---	---					
ALPK3	57538	broad.mit.edu	37	15	85383922	85383922	+	Frame_Shift_Del	DEL	C	C	-	rs143709902	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr15:85383922delC	ENST00000258888.5	+	5	2185	c.2018delC	c.(2017-2019)acfs	p.T673fs		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	673					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CACTCCTTGACCCCCCAGCCG	0.617													17	55	---	---	---	---					
IL34	146433	broad.mit.edu	37	16	70693992	70693993	+	Frame_Shift_Ins	INS	-	-	AGCTG			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:70693992_70693993insAGCTG	ENST00000429149.2	+	7	1186_1187	c.631_632insAGCTG	c.(631-633)gctfs	p.A211fs	IL34_ENST00000566361.1_Frame_Shift_Ins_p.A186fs|IL34_ENST00000288098.2_Frame_Shift_Ins_p.A211fs	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34	211					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						TGCGGCCACCCAGCTGTACCCT	0.649													24	120	---	---	---	---					
