Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SNX25	83891	broad.mit.edu	37	4	186283809	186283809	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:186283809A>G	ENST00000504273.1	+	18	2680	c.2386A>G	c.(2386-2388)Ata>Gta	p.I796V	SNX25_ENST00000264694.8_Missense_Mutation_p.I796V|SNX25_ENST00000512853.1_3'UTR			Q9H3E2	SNX25_HUMAN	sorting nexin 25	796					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCGCCACGGTATAATAAAAAT	0.388000													58	194					0	0	0.014410	0	0
C12orf52	84934	broad.mit.edu	37	12	113624689	113624689	+	Silent	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:113624689G>A	ENST00000548278.1	+	3	830	c.138G>A	c.(136-138)cgG>cgA	p.R46R	RP11-545P7.4_ENST00000552525.1_RNA|C12orf52_ENST00000549621.1_Silent_p.R46R|C12orf52_ENST00000552495.1_Silent_p.R70R	NM_032848.1	NP_116237.1	Q96K30	RITA_HUMAN	chromosome 12 open reading frame 52	46					negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding			large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	5						CAGGCACCCGGCCTACCCCAC	0.642000													7	31					0	0	0.006214	0	0
SLC38A7	55238	broad.mit.edu	37	16	58705074	58705074	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr16:58705074C>A	ENST00000570101.1	-	9	1989	c.1106G>T	c.(1105-1107)cGg>cTg	p.R369L	SLC38A7_ENST00000566953.1_Intron|SLC38A7_ENST00000564100.1_Intron|SLC38A7_ENST00000564010.1_Missense_Mutation_p.R280L|SLC38A7_ENST00000219320.4_Missense_Mutation_p.R369L			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	369					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						CAGCACTCGCCGCCGCCGCTC	0.667000													4	24					0.00909568	0.00983068	0.009096	1	0
OR5D18	219438	broad.mit.edu	37	11	55587567	55587567	+	Silent	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:55587567C>G	ENST00000333976.4	+	1	482	c.462C>G	c.(460-462)gtC>gtG	p.V154V		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CCTGGGGAGTCTCATGTTCCT	0.478000													34	138					0	0	0.013726	0	0
EPPK1	83481	broad.mit.edu	37	8	144940804	144940804	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:144940804C>T	ENST00000525985.1	-	2	6689	c.6618G>A	c.(6616-6618)acG>acA	p.T2206T				P58107	EPIPL_HUMAN	epiplakin 1	2206						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCTTGCGTCGTGCTCCGTC	0.622000													49	196					0	0	0.014410	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349644	134349644	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:134349644G>A	ENST00000275230.5	-	2	1474	c.1319C>T	c.(1318-1320)gCt>gTt	p.A440V		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	440						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GCTTAATCCAGCATTTAGCAA	0.478000													21	73					0	0	0.002780	0	0
KMT2C	58508	broad.mit.edu	37	7	151970855	151970855	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:151970855G>C	ENST00000355193.2	-	7	1165	c.947C>G	c.(946-948)aCc>aGc	p.T316S	KMT2C_ENST00000262189.6_Missense_Mutation_p.T316S					lysine (K)-specific methyltransferase 2C									p.T316S(2)									ATCCTGAAAGGTGCCGGCTCC	0.433000													5	236					0	0	0.001168	0	0
AK4	205	broad.mit.edu	37	1	65684449	65684449	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:65684449C>T	ENST00000395334.2	+	4	636	c.278C>T	c.(277-279)aCa>aTa	p.T93I	AK4_ENST00000546702.1_Missense_Mutation_p.T41I|AK4_ENST00000327299.7_Missense_Mutation_p.T93I|AK4_ENST00000545314.1_Missense_Mutation_p.T93I|AK4_ENST00000470888.2_3'UTR	NM_001005353.2	NP_001005353.1	P27144	KAD4_HUMAN	adenylate kinase 4	93						mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	9						TTTCCTAGGACATTAGGACAA	0.388000													9	42					0	0	0.008291	0	0
NIM1K	167359	broad.mit.edu	37	5	43280501	43280501	+	Silent	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:43280501G>C	ENST00000512796.1	+	4	2480	c.981G>C	c.(979-981)ggG>ggC	p.G327G	NIM1_ENST00000326035.2_Silent_p.G327G			Q8IY84	NIM1_HUMAN		327							ATP binding|magnesium ion binding|protein serine/threonine kinase activity										GGATGCAAGGGGTGCCATACC	0.502000													17	74					0	0	0.004990	0	0
STAB1	23166	broad.mit.edu	37	3	52557481	52557481	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:52557481C>A	ENST00000321725.6	+	65	7255	c.7179C>A	c.(7177-7179)aaC>aaA	p.N2393K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2393	FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ATGCCTCCAACGCCACCCTCC	0.617000													9	21					7.48243e-07	8.99573e-07	0.006214	1	0
HS3ST3B1	9953	broad.mit.edu	37	17	14205268	14205268	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:14205268G>T	ENST00000360954.2	+	1	869	c.433G>T	c.(433-435)Gtg>Ttg	p.V145L		NM_006041.1	NP_006032.1	Q9Y662	HS3SB_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	145					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			large_intestine(3)|lung(3)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CATCATCGGCGTGAAGAAGGG	0.667000													4	19					2.56e-06	3.01011e-06	0.009096	1	0
CCSER1	401145	broad.mit.edu	37	4	91229530	91229530	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:91229530C>T	ENST00000509176.1	+	2	383	c.95C>T	c.(94-96)tCa>tTa	p.S32L	CCSER1_ENST00000432775.2_Missense_Mutation_p.S32L|CCSER1_ENST00000333691.8_Missense_Mutation_p.S32L	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		CTTCCTTCTTCACCTTCTTCC	0.468000													6	34					0	0	0.001984	0	0
LINC00922	283867	broad.mit.edu	37	16	65319299	65319299	+	RNA	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr16:65319299C>T	ENST00000569736.1	-	0	862				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						GGATTGTAGCCTGGCTCCACA	0.473000													7	45					0	0	0.001984	0	0
TLN2	83660	broad.mit.edu	37	15	62989996	62989996	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:62989996G>A	ENST00000561311.1	+	14	1632	c.1402G>A	c.(1402-1404)Gtt>Att	p.V468I	TLN2_ENST00000306829.6_Missense_Mutation_p.V468I			Q9Y4G6	TLN2_HUMAN	talin 2	468					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GACCTTCAACGTTGGCAGCAT	0.667000													17	25					0	0	0.004990	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	99					0	0	0.010729	0	0
ZNF99	7652	broad.mit.edu	37	19	22940099	22940099	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:22940099T>G	ENST00000397104.3	-	6	2231	c.2232A>C	c.(2230-2232)aaA>aaC	p.K744N						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATTTGTAGGGTTTCTTTCCAG	0.348000													12	55					0	0	0.003163	0	0
EPHB2	2048	broad.mit.edu	37	1	23219501	23219501	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:23219501G>A	ENST00000400191.3	+	7	1571	c.1553G>A	c.(1552-1554)cGc>cAc	p.R518H	EPHB2_ENST00000374632.3_Missense_Mutation_p.R518H|EPHB2_ENST00000374630.3_Missense_Mutation_p.R518H|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374627.1_Missense_Mutation_p.R513H	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	518	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GGTTACGGGCGCTACAGCGGC	0.592000													19	50					0	0	0.008871	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999772	46999772	+	Missense_Mutation	SNP	G	G	A	rs148764984		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:46999772G>A	ENST00000374314.4	+	1	1847	c.892G>A	c.(892-894)Ggt>Agt	p.G298S	GPRIN2_ENST00000374317.1_Missense_Mutation_p.G298S			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	298										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CCACCTTTGGGGTCCCGCTGG	0.612000													3	64					0	0	0.004672	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724384	145724384	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:145724384C>T	ENST00000292539.4	+	4	1333	c.416C>T	c.(415-417)aCg>aTg	p.T139M	PPP1R16A_ENST00000435887.1_Missense_Mutation_p.T139M|CTD-2517M14.5_ENST00000569326.1_RNA|CTD-2517M22.14_ENST00000532766.1_RNA			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	139						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GAGTGCTGGACGCCTCTGCAT	0.622000													10	49					0	0	0.010729	0	0
IDO1	3620	broad.mit.edu	37	8	39785691	39785691	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:39785691T>G	ENST00000518237.1	+	10	1838	c.1199T>G	c.(1198-1200)tTg>tGg	p.L400W	IDO1_ENST00000522495.1_Missense_Mutation_p.L400W|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	400					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	AAATCCCTTTTGAAGGAAGGT	0.398000													4	15					0	0	0.009096	0	0
CAMK1D	57118	broad.mit.edu	37	10	12870837	12870837	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:12870837G>A	ENST00000378847.3	+	11	1446	c.1109G>A	c.(1108-1110)cGg>cAg	p.R370Q		NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	370						calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		GGAGCCGAGCGGAGACCCAGG	0.642000													7	26					0	0	0.003080	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469672	120469672	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:120469672C>G	ENST00000283875.5	+	2	366	c.273C>G	c.(271-273)taC>taG	p.Y91*		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	91	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		GCCATAACTACTACTTCATCA	0.398000													9	38					0	0	0.004482	0	0
REEP1	65055	broad.mit.edu	37	2	86459838	86459838	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:86459838C>T	ENST00000165698.5	-	6	648	c.505G>A	c.(505-507)Ggc>Agc	p.G169S	REEP1_ENST00000535845.1_Missense_Mutation_p.G142S|REEP1_ENST00000541910.1_Silent_p.R90R|REEP1_ENST00000540790.1_Missense_Mutation_p.G148S|REEP1_ENST00000538924.1_Missense_Mutation_p.G176S	NM_022912.2	NP_075063.1	Q9H902	REEP1_HUMAN	receptor accessory protein 1	169					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	13						GGTGGGGGGCCCGAGGGAGCA	0.647000													9	25					0	0	0.008291	0	0
PDCD11	22984	broad.mit.edu	37	10	105201732	105201732	+	Splice_Site	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:105201732G>A	ENST00000369797.3	+	31	4801	c.4707_splice	c.e31+1	p.T1569_splice		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1569					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACCAAGCCACGGTGCTGTATT	0.572000													5	35					0	0	0.008291	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													3	13					0	0	0.004672	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													4	131					0	0	0.009096	0	0
FAM155A	728215	broad.mit.edu	37	13	107863084	107863084	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:107863084A>T	ENST00000375915.2	-	2	1073	c.935T>A	c.(934-936)cTc>cAc	p.L312H		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	312						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTGGGAACAGAGCCAGGCTTT	0.413000											OREG0022506	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	41					0	0	0.001984	0	0
ACYP1	97	broad.mit.edu	37	14	75520263	75520263	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:75520263T>C	ENST00000555463.1	-	3	465	c.274A>G	c.(274-276)Atg>Gtg	p.M92V	ACYP1_ENST00000238618.3_Missense_Mutation_p.M62V|ACYP1_ENST00000357971.3_3'UTR|ACYP1_ENST00000555694.1_Missense_Mutation_p.M62V			P07311	ACYP1_HUMAN	acylphosphatase 1, erythrocyte (common) type	62	Acylphosphatase-like.				phosphate metabolic process		acylphosphatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(234;0.00646)		CATTCCTGCATATGACGCACC	0.468000													49	138					0	0	0.014410	0	0
OTOGL	283310	broad.mit.edu	37	12	80655768	80655768	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:80655768G>A	ENST00000458043.2	+	18	1888	c.1882G>A	c.(1882-1884)Gaa>Aaa	p.E628K	OTOGL_ENST00000547103.1_Missense_Mutation_p.E628K	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGGCATGATAGAAGGTACACC	0.398000													11	58					0	0	0.013537	0	0
GRM8	2918	broad.mit.edu	37	7	126746588	126746588	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:126746588C>T	ENST00000339582.2	-	3	1497	c.689G>A	c.(688-690)aGc>aAc	p.S230N	GRM8_ENST00000358373.3_Missense_Mutation_p.S230N|GRM8_ENST00000444921.2_Missense_Mutation_p.S230N|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000405249.1_Missense_Mutation_p.S230N			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	230					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTCCACACCGCTCTCACCATA	0.507000										HNSCC(24;0.065)			10	35					0	0	0.006214	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100551063	100551063	+	RNA	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:100551063G>A	ENST00000397112.4	-	0	1893				AC010203.1_ENST00000408843.1_RNA	NR_036632.1															large_intestine(1)|lung(3)	4						CAGACGCTGGGGCCCCTCTGA	0.607000													17	62					0	0	0.004990	0	0
LCLAT1	253558	broad.mit.edu	37	2	30790956	30790956	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:30790956C>T	ENST00000309052.4	+	6	865	c.656C>T	c.(655-657)gCt>gTt	p.A219V	LCLAT1_ENST00000319406.4_Missense_Mutation_p.A219V|LCLAT1_ENST00000491680.2_3'UTR|LCLAT1_ENST00000359433.1_Missense_Mutation_p.A219V|LCLAT1_ENST00000379509.3_Missense_Mutation_p.A181V|LCLAT1_ENST00000540623.1_Missense_Mutation_p.A181V	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	219					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						AATGCATTTGCTGAAAAAAAT	0.338000													10	54					0	0	0.006214	0	0
C1orf173	127254	broad.mit.edu	37	1	75072553	75072553	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:75072553C>T	ENST00000326665.5	-	10	1439	c.1221G>A	c.(1219-1221)ccG>ccA	p.P407P	C1orf173_ENST00000420661.2_Silent_p.P210P|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	407										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCGGCAAAGACGGTTTTTTGT	0.418000													23	115					0	0	0.003954	0	0
PELP1	27043	broad.mit.edu	37	17	4607440	4607440	+	Silent	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:4607440T>C	ENST00000572293.1	-	1	180	c.117A>G	c.(115-117)tcA>tcG	p.S39S	PELP1_ENST00000301396.4_5'UTR|PELP1_ENST00000269230.7_5'UTR	NM_014389.2	NP_055204.3	Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	662					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						CGTGGCGCGATGACGCAAACA	0.726000													4	11					0	0	0.009096	0	0
MAOA	4128	broad.mit.edu	37	X	43590580	43590580	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:43590580C>T	ENST00000338702.3	+	7	861	c.738C>T	c.(736-738)caC>caT	p.H246H	MAOA_ENST00000542639.1_Silent_p.H113H|MAOA_ENST00000497485.1_3'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	246					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGTCACTCACGTTGACCAGT	0.453000													22	14					0	0	0.014323	0	0
PER1	5187	broad.mit.edu	37	17	8047139	8047139	+	Silent	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:8047139G>A	ENST00000317276.4	-	19	2754	c.2517C>T	c.(2515-2517)gcC>gcT	p.A839A	PER1_ENST00000581082.1_Silent_p.A816A|PER1_ENST00000578089.1_5'UTR	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	839					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GTGAGCGCTTGGCTTTGGATC	0.672000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					16	35					0	0	0.012319	0	0
ZNF767	79970	broad.mit.edu	37	7	149255890	149255890	+	RNA	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:149255890G>C	ENST00000463567.1	-	0	640					NR_027788.1				zinc finger family member 767											central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)	5	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00434)			gtgacaactcgcataagttac	0.488000													8	53					0	0	0.006214	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951241	30951241	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:30951241C>A	ENST00000402321.1	-	3	1288	c.971G>T	c.(970-972)cGg>cTg	p.R324L	GAL3ST1_ENST00000338911.5_Missense_Mutation_p.R324L|GAL3ST1_ENST00000402369.1_Missense_Mutation_p.R324L|GAL3ST1_ENST00000401975.1_Missense_Mutation_p.R324L|GAL3ST1_ENST00000443111.2_Missense_Mutation_p.R324L|GAL3ST1_ENST00000406361.1_Missense_Mutation_p.R324L|GAL3ST1_ENST00000406955.1_Missense_Mutation_p.R324L			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	324					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						CATGCGCTCCCGCCCGAAGGC	0.711000													5	10					3.59834e-05	4.05286e-05	0.001168	1	0
BAGE2	85319	broad.mit.edu	37	21	11039224	11039224	+	RNA	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr21:11039224T>C	ENST00000470054.1	-	0	979									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTGATTCTTCTTTGGATACCA	0.423000													11	246					0	0	0.008291	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47591350	47591350	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:47591350C>T	ENST00000371917.4	+	13	1713	c.1713C>T	c.(1711-1713)ctC>ctT	p.L571L		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	571					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGTCCATTCTCAAGTGCATGG	0.507000													8	17					0	0	0.013537	0	0
GPR22	2845	broad.mit.edu	37	7	107114861	107114861	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:107114861A>G	ENST00000304402.4	+	3	1699	c.356A>G	c.(355-357)gAg>gGg	p.E119G	COG5_ENST00000347053.3_Intron|COG5_ENST00000297135.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000393603.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	119						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						TGTTTCCATGAGGCTTGTGTA	0.388000													28	81					0	0	0.007291	0	0
ATF1	466	broad.mit.edu	37	12	51173954	51173954	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:51173954C>T	ENST00000262053.3	+	2	48	c.26C>T	c.(25-27)aCg>aTg	p.T9M	ATF1_ENST00000539132.1_5'UTR	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	9					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						AAGAGTACCACGTCAGAGACA	0.408000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								68	177					0	0	0.014410	0	0
ATP2A2	488	broad.mit.edu	37	12	110783837	110783837	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:110783837C>T	ENST00000395494.2	+	18	3255	c.2692C>T	c.(2692-2694)Ccc>Tcc	p.P898S	ATP2A2_ENST00000308664.6_Missense_Mutation_p.P925S|ATP2A2_ENST00000539276.2_Missense_Mutation_p.P925S			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	925					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						GCTGAGGATGCCCCCCTGGGA	0.577000													4	83					0	0	0.009096	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756943	56756943	+	Silent	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:56756943T>G	ENST00000326855.2	+	1	597	c.555T>G	c.(553-555)ctT>ctG	p.L185L		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						CCCCTATTCTTGCTCTTTCAT	0.403000													48	221					0	0	0.014410	0	0
FOXB1	27023	broad.mit.edu	37	15	60297484	60297484	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:60297484C>A	ENST00000396057.4	+	2	801	c.322C>A	c.(322-324)Cgc>Agc	p.R108S	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	108					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						GCGCCGCAAGCGCTTCAAGGT	0.706000													10	17					6.40141e-05	7.13491e-05	0.010729	1	0
MC5R	4161	broad.mit.edu	37	18	13826449	13826449	+	Silent	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr18:13826449C>A	ENST00000324750.3	+	1	907	c.685C>A	c.(685-687)Cgg>Agg	p.R229R		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	229				ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding	p.R229W(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CAGCTCTGCGCGGCAGAGGAC	0.617000													35	137					3.03874e-20	3.87078e-20	0.003271	1	0
RXFP2	122042	broad.mit.edu	37	13	32371542	32371542	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:32371542G>A	ENST00000298386.2	+	17	2062	c.1991G>A	c.(1990-1992)cGg>cAg	p.R664Q	RXFP2_ENST00000380314.1_Missense_Mutation_p.R640Q	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	664						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TCCCTCTTCCGGGTGGAAATA	0.423000													3	88					0	0	0.004672	0	0
KRT31	3881	broad.mit.edu	37	17	39551520	39551520	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:39551520C>G	ENST00000251645.2	-	5	905	c.853G>C	c.(853-855)Gag>Cag	p.E285Q		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	285	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GCCTGCAGCTCGATCTCCAGG	0.607000													14	64					0	0	0.003163	0	0
ERBB4	2066	broad.mit.edu	37	2	212426697	212426697	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:212426697C>G	ENST00000342788.4	-	20	2728	c.2418G>C	c.(2416-2418)gaG>gaC	p.E806D	ERBB4_ENST00000402597.1_Missense_Mutation_p.E796D|ERBB4_ENST00000436443.1_Missense_Mutation_p.E806D	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	806	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGTGGACATACTCCAACAGGC	0.483000										TSP Lung(8;0.080)			27	107					0	0	0.010818	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564673	33564673	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:33564673G>C	ENST00000321505.4	+	1	853	c.673G>C	c.(673-675)Gaa>Caa	p.E225Q	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.E225Q|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.E225Q					KIAA1549-like																		TCCTGTGCCAGAAATGCCCAC	0.537000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	74					0	0	0.004990	0	0
VPS52	6293	broad.mit.edu	37	6	33234453	33234453	+	Missense_Mutation	SNP	C	C	T	rs146611103		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:33234453C>T	ENST00000445902.2	-	12	1380	c.1162G>A	c.(1162-1164)Gcc>Acc	p.A388T	VPS52_ENST00000478934.1_5'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.A263T|VPS52_ENST00000482399.1_3'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	388					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						TCTAGGAGGGCGTAGTGCTGG	0.522000													7	51					0	0	0.001984	0	0
HELZ	9931	broad.mit.edu	37	17	65174905	65174905	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:65174905T>C	ENST00000358691.5	-	13	1466	c.1300A>G	c.(1300-1302)Att>Gtt	p.I434V	HELZ_ENST00000580168.1_Missense_Mutation_p.I434V	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GAGAGGGGAATTTGGTATCTG	0.383000													5	102					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000445888.2_Missense_Mutation_p.R175H|TP53_ENST00000269305.4_Missense_Mutation_p.R175H|TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000413465.2_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	48					0	0	0.001855	0	0
BCORL1	63035	broad.mit.edu	37	X	129147297	129147297	+	Silent	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:129147297C>A	ENST00000540052.1	+	3	593	c.549C>A	c.(547-549)gtC>gtA	p.V183V	BCORL1_ENST00000359304.2_Silent_p.V183V|BCORL1_ENST00000218147.7_Silent_p.V183V|BCORL1_ENST00000303743.5_Silent_p.V183V	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	183					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GAACTGGAGTCCCTGTGGAGG	0.577000													9	30					0.000978159	0.001079	0.010729	1	0
DDX58	23586	broad.mit.edu	37	9	32488812	32488812	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr9:32488812C>T	ENST00000379882.1	-	6	895	c.738G>A	c.(736-738)ggG>ggA	p.G246G	DDX58_ENST00000379883.2_Silent_p.G291G|DDX58_ENST00000542096.1_Silent_p.G220G|DDX58_ENST00000545044.1_Silent_p.G88G|DDX58_ENST00000379868.1_Silent_p.G88G			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	291					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AGACAACTTTCCCCTTTTGTC	0.338000													10	29					0	0	0.006214	0	0
DUSP22	56940	broad.mit.edu	37	6	348863	348863	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:348863G>T	ENST00000604971.1	+	4	1334	c.221G>T	c.(220-222)cGc>cTc	p.R74L	DUSP22_ENST00000344450.5_Intron|DUSP22_ENST00000419235.2_Missense_Mutation_p.R177L|DUSP22_ENST00000603453.1_Missense_Mutation_p.R74L|DUSP22_ENST00000605315.1_Missense_Mutation_p.R74L|DUSP22_ENST00000605035.1_3'UTR			Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	0	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GAGCAAGGGCGCACAGAGCCC	0.552000													3	31					0.004672	0.00510106	0.004672	1	0
TAS2R1	50834	broad.mit.edu	37	5	9629960	9629960	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:9629960A>G	ENST00000382492.2	-	1	503	c.185T>C	c.(184-186)aTc>aCc	p.I62T	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	62					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						AACGTAGAAGATGAACAACTG	0.368000													22	28					0	0	0.003330	0	0
PICALM	8301	broad.mit.edu	37	11	85779753	85779753	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:85779753T>G	ENST00000526033.1	-	1	386	c.70A>C	c.(70-72)Aag>Cag	p.K24Q	PICALM_ENST00000532317.1_Missense_Mutation_p.K24Q|PICALM_ENST00000393346.3_Missense_Mutation_p.K24Q|PICALM_ENST00000528411.1_5'UTR|PICALM_ENST00000356360.5_Missense_Mutation_p.K24Q|PICALM_ENST00000528398.1_Intron	NM_001206946.1|NM_007166.3	NP_001193875.1|NP_009097.2	Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	24	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CATACTGTCTTGGATACGGCA	0.662000			T	"""MLLT10, MLL"""	"""TALL, AML, """								10	16					0	0	0.013537	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50664505	50664505	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:50664505T>A	ENST00000439308.2	-	9	2299	c.1807A>T	c.(1807-1809)Aac>Tac	p.N603Y	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.N603Y	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	603					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTCAGCAGGTTAATGGTCTTT	0.582000													6	140					0	0	0.001168	0	0
SGK3	23678	broad.mit.edu	37	8	67771691	67771691	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:67771691G>C	ENST00000396596.1	+	17	1580	c.1366G>C	c.(1366-1368)Gaa>Caa	p.E456Q	C8orf44-SGK3_ENST00000519289.1_Missense_Mutation_p.E456Q|SGK3_ENST00000521198.2_Missense_Mutation_p.E456Q|SGK3_ENST00000520976.1_Missense_Mutation_p.E424Q|SGK3_ENST00000345714.4_Missense_Mutation_p.E456Q|SGK3_ENST00000522398.1_Missense_Mutation_p.E456Q	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	456	AGC-kinase C-terminal.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATTTACAGAAGAAACAGTTCC	0.363000													36	72					0	0	0.003755	0	0
OR12D2	26529	broad.mit.edu	37	6	29365111	29365111	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:29365111C>T	ENST00000383555.2	+	1	696	c.635C>T	c.(634-636)aCa>aTa	p.T212I	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TTCTTTCTGACACTTCTCTCC	0.468000													22	147					0	0	0.012319	0	0
OR10R2	343406	broad.mit.edu	37	1	158450102	158450102	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:158450102C>T	ENST00000368152.1	+	1	435	c.435C>T	c.(433-435)gcC>gcT	p.A145A	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					GCTATGCTGCCATTTGTCACC	0.488000													45	205					0	0	0.014410	0	0
PCNXL2	80003	broad.mit.edu	37	1	233313598	233313598	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:233313598G>T	ENST00000258229.8	-	17	3457	c.3223C>A	c.(3223-3225)Ctg>Atg	p.L1075M	PCNXL2_ENST00000488780.2_Missense_Mutation_p.L208M	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1075						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GACTCTGCCAGATTTTGATGT	0.428000													4	52					1.23904e-05	1.42556e-05	0.000602	1	0
FOXJ2	55810	broad.mit.edu	37	12	8200482	8200482	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:8200482T>A	ENST00000162391.3	+	7	1967	c.822T>A	c.(820-822)ttT>ttA	p.F274L	FOXJ2_ENST00000428177.2_Missense_Mutation_p.F274L	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	274					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		CTGCAGGCTTTTCTTCTCTCC	0.532000													18	67					0	0	0.008871	0	0
RIC8B	55188	broad.mit.edu	37	12	107254159	107254159	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:107254159G>T	ENST00000392837.4	+	8	1571	c.1420G>T	c.(1420-1422)Gac>Tac	p.D474Y	RIC8B_ENST00000549643.1_5'UTR|RIC8B_ENST00000355478.2_Missense_Mutation_p.D434Y|RIC8B_ENST00000392839.2_Missense_Mutation_p.D474Y			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	474					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						TGAGGACACAGACACTGAAGA	0.438000													6	31					3.59834e-05	4.05286e-05	0.001168	1	0
CSMD1	64478	broad.mit.edu	37	8	3351179	3351179	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:3351179C>T	ENST00000520002.1	-	12	1972	c.1417G>A	c.(1417-1419)Ggg>Agg	p.G473R	CSMD1_ENST00000537824.1_Missense_Mutation_p.G472R|CSMD1_ENST00000539096.1_Missense_Mutation_p.G472R|CSMD1_ENST00000602723.1_Missense_Mutation_p.G473R|CSMD1_ENST00000400186.3_Missense_Mutation_p.G473R|CSMD1_ENST00000602557.1_Missense_Mutation_p.G473R|CSMD1_ENST00000542608.1_Missense_Mutation_p.G472R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	473	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCACCTTCCCAGCATCACCA	0.507000													4	9					0	0	0.000602	0	0
SON	6651	broad.mit.edu	37	21	34931551	34931551	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr21:34931551G>A	ENST00000356577.4	+	5	6812	c.6337G>A	c.(6337-6339)Gca>Aca	p.A2113T	SON_ENST00000300278.4_Missense_Mutation_p.A2113T|SON_ENST00000290239.6_Missense_Mutation_p.A2113T|SON_ENST00000381692.2_Missense_Mutation_p.A141T	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	2113					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TAAACAGATCGCACAGAGTAA	0.308000													12	42					0	0	0.013537	0	0
TEX15	56154	broad.mit.edu	37	8	30703495	30703495	+	Silent	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:30703495T>C	ENST00000256246.2	-	1	3113	c.3039A>G	c.(3037-3039)acA>acG	p.T1013T		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1013										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTGCAAAGATGTGTGAACTC	0.343000													42	98					0	0	0.014410	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033054	52033054	+	Silent	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:52033054T>G	ENST00000346477.3	-	4	956	c.888A>C	c.(886-888)gcA>gcC	p.A296A	SIGLEC6_ENST00000436458.1_Silent_p.A260A|SIGLEC6_ENST00000425629.3_Silent_p.A312A|SIGLEC6_ENST00000343300.4_Silent_p.A312A|SIGLEC6_ENST00000391797.3_Silent_p.A301A|SIGLEC6_ENST00000359982.4_Silent_p.A323A	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	312	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTCCTTCTTCTGCAGACCCTA	0.607000													14	32					0	0	0.002450	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819421	50819421	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:50819421G>C	ENST00000374115.3	+	1	1075	c.635G>C	c.(634-636)cGt>cCt	p.R212P	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	212					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						GAGCGCAGTCGTGCACTGGGC	0.672000													4	13					0	0	0.009096	0	0
MARK3	4140	broad.mit.edu	37	14	103958157	103958157	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:103958157A>G	ENST00000429436.2	+	15	2140	c.1630A>G	c.(1630-1632)Atc>Gtc	p.I544V	MARK3_ENST00000335102.5_Missense_Mutation_p.I567V|MARK3_ENST00000303622.9_Missense_Mutation_p.I544V|MARK3_ENST00000440884.3_Missense_Mutation_p.I465V|MARK3_ENST00000216288.7_Missense_Mutation_p.I528V|MARK3_ENST00000553942.1_Missense_Mutation_p.I544V|MARK3_ENST00000561071.1_3'UTR|MARK3_ENST00000416682.2_Missense_Mutation_p.I567V	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	544							ATP binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			AACACACAGTATCAGTAGTGC	0.488000													11	45					0	0	0.008291	0	0
C1orf51	148523	broad.mit.edu	37	1	150255844	150255844	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:150255844G>C	ENST00000290363.5	+	1	616	c.167G>C	c.(166-168)cGg>cCg	p.R56P	C1orf51_ENST00000469255.1_3'UTR|C1orf51_ENST00000369094.1_Intron|C1orf51_ENST00000369095.1_Missense_Mutation_p.R56P	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	56										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAGGTTCACGGCCCAGCCCG	0.602000													8	170					0	0	0.006214	0	0
MEPE	56955	broad.mit.edu	37	4	88755893	88755893	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:88755893C>T	ENST00000395102.4	+	2	137	c.27C>T	c.(25-27)ctC>ctT	p.L9L	MEPE_ENST00000560249.1_5'UTR|MEPE_ENST00000361056.3_Silent_p.L9L|MEPE_ENST00000540395.1_5'UTR|MEPE_ENST00000424957.3_Silent_p.L9L|MEPE_ENST00000511670.1_Silent_p.L9L|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000497649.2_5'UTR			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	9					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TGGGACTACTCCTTTTCAGTG	0.368000													17	76					0	0	0.012319	0	0
PKIG	11142	broad.mit.edu	37	20	43246985	43246985	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:43246985G>T	ENST00000372889.1	+	6	796	c.211G>T	c.(211-213)Gat>Tat	p.D71Y	Z97053.1_ENST00000597250.1_Intron|PKIG_ENST00000372891.3_Missense_Mutation_p.D71Y|PKIG_ENST00000372886.1_Missense_Mutation_p.D71Y|PKIG_ENST00000372887.1_Intron|PKIG_ENST00000349959.3_Missense_Mutation_p.D71Y|PKIG_ENST00000372892.3_Missense_Mutation_p.D71Y|PKIG_ENST00000372882.3_Intron|PKIG_ENST00000372894.3_Missense_Mutation_p.D71Y			Q9Y2B9	IPKG_HUMAN	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	71							cAMP-dependent protein kinase inhibitor activity|protein binding			breast(1)|urinary_tract(1)	2		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CCAGAGCAGCGATGGGACCAC	0.587000													37	132					9.62906e-15	1.18426e-14	0.006230	1	0
PCSK5	5125	broad.mit.edu	37	9	78969062	78969062	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr9:78969062C>T	ENST00000545128.1	+	36	5638	c.5100C>T	c.(5098-5100)agC>agT	p.S1700S		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	765					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TGGACGACAGCCACTGCCTCC	0.602000													3	10					0	0	0.004672	0	0
UBB	7314	broad.mit.edu	37	17	16285788	16285788	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:16285788C>T	ENST00000302182.3	+	2	959	c.567C>T	c.(565-567)ccC>ccT	p.P189P	UBB_ENST00000395837.1_Silent_p.P189P|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000578649.1_3'UTR|UBB_ENST00000395839.1_Silent_p.P189P|UBB_ENST00000535788.1_Silent_p.P113P	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	189	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding	p.P189P(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AAGGCATCCCCCCCGACCAGC	0.552000													4	67					0	0	0.009096	0	0
LATS1	9113	broad.mit.edu	37	6	150001304	150001304	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:150001304C>A	ENST00000543571.1	-	5	2847	c.2300G>T	c.(2299-2301)cGt>cTt	p.R767L	LATS1_ENST00000253339.5_Missense_Mutation_p.R767L|LATS1_ENST00000542747.1_5'UTR	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	767	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATAATATAGACGAACTACCCA	0.373000													22	58					3.7963e-18	4.72331e-18	0.003330	1	0
HIST1H2AG	8969	broad.mit.edu	37	6	27100994	27100994	+	Silent	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:27100994G>T	ENST00000359193.2	+	1	163	c.144G>T	c.(142-144)gcG>gcT	p.A48A		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	48					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						GGGCCGGCGCGCCGGTGTATC	0.682000													14	58					9.31168e-06	1.08299e-05	0.001855	1	0
TACR2	6865	broad.mit.edu	37	10	71175838	71175838	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:71175838C>T	ENST00000373306.4	-	1	785	c.242G>A	c.(241-243)tGc>tAc	p.C81Y		NM_001057.2	NP_001048.2	P21452	NK2R_HUMAN	tachykinin receptor 2	81					excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	11					Clonidine(DB00575)|Octreotide(DB00104)	GGCAGCCATGCAGAGGTCAGC	0.547000													11	16					0	0	0.008291	0	0
MOGS	7841	broad.mit.edu	37	2	74689540	74689540	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:74689540A>G	ENST00000233616.4	-	4	1538	c.1376T>C	c.(1375-1377)gTt>gCt	p.V459A	MOGS_ENST00000409065.1_3'UTR|MOGS_ENST00000452063.2_Missense_Mutation_p.V353A	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	459					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						CCACCGCTGAACCACCAGCTG	0.597000													6	34					0	0	0.001168	0	0
PCDH10	57575	broad.mit.edu	37	4	134072815	134072815	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:134072815T>C	ENST00000264360.4	+	1	2346	c.1520T>C	c.(1519-1521)aTc>aCc	p.I507T		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	507	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GAGTGCCAGATCCAGGGCATG	0.577000													22	71					0	0	0.014323	0	0
COL4A2	1284	broad.mit.edu	37	13	111117869	111117869	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:111117869C>T	ENST00000360467.5	+	25	2200	c.1894C>T	c.(1894-1896)Cgt>Tgt	p.R632C		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	632	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAAAGGCCAACGTGGTTTCCC	0.632000													9	34					0	0	0.004482	0	0
WIPF1	7456	broad.mit.edu	37	2	175437112	175437112	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:175437112A>G	ENST00000392547.2	-	5	520	c.421T>C	c.(421-423)Ttt>Ctt	p.F141L	WIPF1_ENST00000392546.2_Missense_Mutation_p.F141L|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000409891.1_Missense_Mutation_p.F141L|WIPF1_ENST00000409415.3_Missense_Mutation_p.F141L|WIPF1_ENST00000359761.3_Missense_Mutation_p.F141L|AC018890.6_ENST00000412835.1_RNA|WIPF1_ENST00000272746.5_Missense_Mutation_p.F141L	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	141					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						GGGGGTGAAAAGGGTTTCGCA	0.562000													3	51					0	0	0.004672	0	0
GJC1	10052	broad.mit.edu	37	17	42882699	42882699	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:42882699C>A	ENST00000426548.1	-	3	756	c.487G>T	c.(487-489)Gat>Tat	p.D163Y	GJC1_ENST00000330514.4_Missense_Mutation_p.D163Y|GJC1_ENST00000590758.1_Missense_Mutation_p.D163Y|GJC1_ENST00000592524.1_Missense_Mutation_p.D163Y	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	163					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				CGTCGGCCATCATGCTTAGGT	0.478000													27	127					6.12954e-19	7.716e-19	0.004656	1	0
ABRA	137735	broad.mit.edu	37	8	107782152	107782152	+	Silent	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:107782152A>G	ENST00000311955.3	-	1	321	c.267T>C	c.(265-267)caT>caC	p.H89H		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	89					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GTCCATCTCCATGTCCTTCTG	0.532000													13	129					0	0	0.001855	0	0
TRMT13	54482	broad.mit.edu	37	1	100602603	100602603	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:100602603C>A	ENST00000370141.2	+	3	229	c.223C>A	c.(223-225)Cat>Aat	p.H75N	TRMT13_ENST00000370143.1_Missense_Mutation_p.H75N|TRMT13_ENST00000370139.1_Missense_Mutation_p.H44N	NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		ACTAGCAAAGCATTTGAAAAA	0.328000													10	55					2.80697e-09	3.41303e-09	0.010729	1	0
MCM8	84515	broad.mit.edu	37	20	5974238	5974238	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:5974238C>G	ENST00000378896.3	+	18	2704	c.2327C>G	c.(2326-2328)gCg>gGg	p.A776G	MCM8_ENST00000378883.1_Missense_Mutation_p.A729G|MCM8_ENST00000265187.4_Missense_Mutation_p.A760G|MCM8_ENST00000378886.2_Missense_Mutation_p.A816G	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	776					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						AGGTCAACAGCGAAAAGATTT	0.368000													18	93					0	0	0.006122	0	0
NRD1	4898	broad.mit.edu	37	1	52256303	52256304	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:52256303_52256304insCC	ENST00000354831.7	-	31	3462_3463	c.3273_3274insGG	c.(3271-3276)aatgaafs	p.NE1091fs	NRD1_ENST00000539524.1_Frame_Shift_Ins_p.NE959fs|NRD1_ENST00000352171.7_Frame_Shift_Ins_p.NE1023fs|NRD1_ENST00000485608.1_5'UTR	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	1022					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						CACTCCTTCAGCTTGATGAGAG	0.545													14	67	---	---	---	---					
RBM15	64783	broad.mit.edu	37	1	110884597	110884598	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:110884597_110884598insT	ENST00000369784.3	+	1	3470_3471	c.2570_2571insT	c.(2569-2571)tgcfs	p.C857fs	RBM15_ENST00000487146.2_Frame_Shift_Ins_p.C857fs|RBM15_ENST00000602849.1_Frame_Shift_Ins_p.C857fs	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	857	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCAATGGTTATGCCATTCTTT	0.540			T	MKL1	acute megakaryocytic leukemia								53	111	---	---	---	---					
ZNF687	57592	broad.mit.edu	37	1	151261022	151261023	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:151261022_151261023insT	ENST00000368879.2	+	3	2232_2233	c.2134_2135insT	c.(2134-2136)gatfs	p.D712fs		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AACCTGCCCCATGATGCTCCCC	0.574													16	50	---	---	---	---					
TGOLN2	10618	broad.mit.edu	37	2	85554626	85554627	+	In_Frame_Ins	INS	-	-	GGT	rs76078295		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:85554626_85554627insGGT	ENST00000377386.3	-	2	690_691	c.228_229insACC	c.(226-231)accaga>acACCcaga	p.76_77TR>TPR	TGOLN2_ENST00000282120.2_Intron|TGOLN2_ENST00000409015.1_In_Frame_Ins_p.76_77TR>TPR|TGOLN2_ENST00000398263.2_In_Frame_Ins_p.76_77TR>TPR|TGOLN2_ENST00000409232.3_In_Frame_Ins_p.76_77TR>TPR|TGOLN2_ENST00000444342.2_In_Frame_Ins_p.76_77TR>TPR			O43493	TGON2_HUMAN	trans-golgi network protein 2	76	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										GTGTCTTCTGGGGTCTGCGCCT	0.599													33	299	---	---	---	---					
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:113704096_113704098delCTG	ENST00000550785.1	+	5	734_736	c.565_567delCTG	c.(565-567)del	p.L194del	TPCN1_ENST00000335509.6_In_Frame_Del_p.L122del|TPCN1_ENST00000541517.1_In_Frame_Del_p.L194del|TPCN1_ENST00000392569.4_In_Frame_Del_p.L54del	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	122						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGCCACGGCCCTGCTGCTGCTGC	0.640													8	455	---	---	---	---					
ZBTB25	7597	broad.mit.edu	37	14	64954345	64954345	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:64954345delA	ENST00000394715.1	-	6	1305	c.604delT	c.(604-606)ccfs	p.S202fs	ZBTB25_ENST00000555220.1_Intron|ZBTB25_ENST00000555424.1_Intron|ZBTB25_ENST00000261683.2_Frame_Shift_Del_p.S202fs			P24278	ZBT25_HUMAN	zinc finger and BTB domain containing 25	202						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(2)|skin(2)	10				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TGCTTGATGGAAACTGGGGGC	0.567													61	221	---	---	---	---					
USP9X	8239	broad.mit.edu	37	X	41088557	41088563	+	Frame_Shift_Del	DEL	CACAATC	CACAATC	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:41088557_41088563delCACAATC	ENST00000324545.7	+	42	7746_7752	c.7113_7119delCACAATC	c.(7111-7119)gafs	p.DTI2371fs	USP9X_ENST00000378308.2_Frame_Shift_Del_p.DTI2371fs	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2371					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						GGCTGTTTGACACAATCCAGCGCTCTA	0.362													5	5	---	---	---	---					
