Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BANK1	55024	broad.mit.edu	37	4	102981427	102981427	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr4:102981427C>A	ENST00000504592.1	+	16	2402	c.1984C>A	c.(1984-1986)Cag>Aag	p.Q662K	BANK1_ENST00000322953.4_Missense_Mutation_p.Q677K|BANK1_ENST00000428908.1_Missense_Mutation_p.Q544K|BANK1_ENST00000508653.1_Missense_Mutation_p.Q544K|BANK1_ENST00000444316.2_Missense_Mutation_p.Q647K			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	677					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AACTGATGGTCAGGAAGAACT	0.453000													40	61					5.71845e-15	6.74265e-15	1	1	0
CAMK2A	815	broad.mit.edu	37	5	149629830	149629830	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr5:149629830C>T	ENST00000348628.6	-	11	1524	c.859G>A	c.(859-861)Gtg>Atg	p.V287M	CAMK2A_ENST00000398376.3_Missense_Mutation_p.V287M	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	287					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGCAGTCCACGGTCTCCTGT	0.602000													23	41					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90028152	90028152	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:90028152G>A	ENST00000563594.1	+	8	1684	c.687G>A	c.(685-687)gtG>gtA	p.V229V	DEF8_ENST00000563848.1_3'UTR|DEF8_ENST00000570182.1_Silent_p.V219V|DEF8_ENST00000569453.1_Silent_p.V229V|DEF8_ENST00000563795.1_Silent_p.V229V|DEF8_ENST00000567874.1_Silent_p.V169V|DEF8_ENST00000268676.7_Silent_p.V290V	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	290					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CAGGGGGTGTGCCCAGTGAGG	0.617000													26	32					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42660617	42660617	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:42660617C>A	ENST00000372572.1	-	10	1189	c.878G>T	c.(877-879)aGt>aTt	p.S293I	FOXJ3_ENST00000545068.1_Missense_Mutation_p.S293I|FOXJ3_ENST00000372573.1_Missense_Mutation_p.S293I|FOXJ3_ENST00000361776.1_Missense_Mutation_p.S259I|FOXJ3_ENST00000361346.1_Missense_Mutation_p.S293I	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	293					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AAATGAGGCACTAAGATCTTC	0.348000													70	116					1.64915e-30	2.03567e-30	1	1	0
ANKS1A	23294	broad.mit.edu	37	6	34957002	34957002	+	Splice_Site	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr6:34957002G>A	ENST00000360359.3	+	9	1349	c.1209_splice	c.e9-1	p.R404_splice	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	404						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CTTCTGCAGAGGGAACGTCCA	0.393000													52	85					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144650814	144650814	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr8:144650814G>A	ENST00000398882.3	-	10	1808	c.1552C>T	c.(1552-1554)Ctg>Ttg	p.L518L	MROH6_ENST00000533679.1_5'UTR|MROH6_ENST00000524906.1_5'UTR|MROH6_ENST00000534459.1_5'UTR	NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		cggagccccagccggagcccg	0.741000													4	1					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173873136	173873136	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:173873136G>A	ENST00000367698.3	-	7	1404	c.1286C>T	c.(1285-1287)cCc>cTc	p.P429L		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	429					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CACCCTGTTGGGGTTTAGCGA	0.458000													43	57					0	0	1	0	0
TTTY11	83866	broad.mit.edu	37	Y	8657050	8657050	+	RNA	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chrY:8657050C>T	ENST00000253470.4	-	0	414					NR_001548.2																						CTTTAAAATCCGCTTTAGTCG	0.373000													18	0					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2051046	2051046	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:2051046C>T	ENST00000563630.1	-	7	1237	c.995G>A	c.(994-996)cGt>cAt	p.R332H	ZNF598_ENST00000431526.1_Missense_Mutation_p.R387H|ZNF598_ENST00000562103.1_Missense_Mutation_p.R332H			Q86UK7	ZN598_HUMAN	zinc finger protein 598	387						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CCGGGGGCCACGGGGATCCTC	0.692000													4	5					0	0	1	0	0
HIST3H2BB	128312	broad.mit.edu	37	1	228645862	228645862	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:228645862C>T	ENST00000369160.2	+	1	55	c.32C>T	c.(31-33)cCc>cTc	p.P11L		NM_175055.2	NP_778225.1	Q8N257	H2B3B_HUMAN	histone cluster 3, H2bb	11					nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		Prostate(94;0.183)				GCTCCTGCGCCCAAGAAGGGT	0.527000													46	69					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801542	140801542	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr5:140801542G>A	ENST00000398587.2	+	1	781	c.748G>A	c.(748-750)Gtg>Atg	p.V250M	PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.V250M|PCDHGB7_ENST00000398594.2_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATATCGCGTGAGTGTTCC	0.498000													82	100					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30673819	30673819	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr6:30673819G>A	ENST00000376406.3	-	10	3788	c.3141C>T	c.(3139-3141)gcC>gcT	p.A1047A	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Silent_p.A783A	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1047	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TTTGGGGTGGGGCTGGGGCTT	0.532000								Other conserved DNA damage response genes					63	79					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20137643	20137643	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr2:20137643G>A	ENST00000345530.3	-	20	2276	c.2161C>T	c.(2161-2163)Cgc>Tgc	p.R721C	WDR35_ENST00000416055.2_Missense_Mutation_p.R286C|WDR35_ENST00000281405.4_Missense_Mutation_p.R710C	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	721										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTGCAGCGCACAAATGCT	0.428000													4	147					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68125186	68125186	+	Missense_Mutation	SNP	G	G	A	rs146895334		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr11:68125186G>A	ENST00000294304.7	+	3	663	c.557G>A	c.(556-558)cGg>cAg	p.R186Q		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	186	Beta-propeller 1.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGCAGCACCCGGAAGATCATT	0.587000													3	39					0	0	1	0	0
TRGV2	6974	broad.mit.edu	37	7	38403051	38403051	+	RNA	SNP	G	G	C	rs4993385	by1000genomes	TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:38403051G>C	ENST00000426402.2	-	0	68																											GTAGGAGGAGGTGGTCTTCCT	0.527000													3	10					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15694386	15694386	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:15694386G>T	ENST00000396368.3	-	25	4918	c.4712C>A	c.(4711-4713)tCc>tAc	p.S1571Y	KIAA0430_ENST00000551742.1_Missense_Mutation_p.S1571Y|KIAA0430_ENST00000548025.1_Missense_Mutation_p.S1568Y|KIAA0430_ENST00000602337.1_Missense_Mutation_p.S1568Y|KIAA0430_ENST00000540441.2_Missense_Mutation_p.S1406Y|KIAA0430_ENST00000344181.3_Missense_Mutation_p.S1259Y	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1570						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						ATTGGCAGGGGAGAGACTGAG	0.562000													20	95					4.35082e-09	4.77381e-09	1	1	0
SEMA3C	10512	broad.mit.edu	37	7	80430072	80430072	+	Splice_Site	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:80430072C>A	ENST00000265361.3	-	10	1548		c.e10+1		SEMA3C_ENST00000544525.1_Splice_Site|SEMA3C_ENST00000419255.2_Splice_Site|SEMA3C_ENST00000536800.1_Splice_Site	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C						immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGAATAATTACCTTGATGTTG	0.289000													23	36					7.92952e-12	9.21224e-12	1	1	0
CNGB3	54714	broad.mit.edu	37	8	87641258	87641258	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr8:87641258C>T	ENST00000320005.5	-	12	1416	c.1369G>A	c.(1369-1371)Gcc>Acc	p.A457T		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	457					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TCCATGCAGGCGCGGAAGTAG	0.443000													65	202					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736453	140736453	+	Silent	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr5:140736453C>A	ENST00000571252.1	+	1	1686	c.1686C>A	c.(1684-1686)atC>atA	p.I562I	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCTGAGATCCTGTACCCCA	0.582000													122	240					4.94232e-47	6.29747e-47	1	1	0
CSRNP3	80034	broad.mit.edu	37	2	166533063	166533063	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr2:166533063G>T	ENST00000314499.7	+	6	1026	c.650G>T	c.(649-651)cGa>cTa	p.R217L	CSRNP3_ENST00000409420.1_Missense_Mutation_p.R249L|CSRNP3_ENST00000342316.4_Missense_Mutation_p.R217L	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	217	Cys-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						TGTGACTGCCGAGTGTTCTGT	0.542000													35	16					5.8336e-16	7.09007e-16	1	1	0
OR13G1	441933	broad.mit.edu	37	1	247835701	247835701	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:247835701A>T	ENST00000359688.2	-	1	664	c.643T>A	c.(643-645)Tat>Aat	p.Y215N	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATAAAACCATAGGAGATGCAG	0.458000													29	45					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40421045	40421045	+	Silent	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:40421045G>T	ENST00000372809.5	+	1	224	c.81G>T	c.(79-81)ccG>ccT	p.P27P	MFSD2A_ENST00000420632.2_5'UTR|MFSD2A_ENST00000372811.5_Silent_p.P27P	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	27					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CTGAACGCCCGGCCCAGGTGA	0.731000													8	16					2.17888e-05	2.35796e-05	1	1	0
TAF1L	138474	broad.mit.edu	37	9	32631299	32631299	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr9:32631299G>C	ENST00000242310.4	-	1	4368	c.4279C>G	c.(4279-4281)Cca>Gca	p.P1427A		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1427	Bromo 1.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.P1427T(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCATTGACTGGAGTGTGGAAA	0.478000													14	290					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48189110	48189110	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr12:48189110C>T	ENST00000080059.7	-	11	1140	c.1141G>A	c.(1141-1143)Gag>Aag	p.E381K	HDAC7_ENST00000552960.1_Missense_Mutation_p.E364K|HDAC7_ENST00000380610.4_Missense_Mutation_p.E398K|HDAC7_ENST00000354334.3_Missense_Mutation_p.E344K|HDAC7_ENST00000427332.2_Missense_Mutation_p.E342K	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	342	Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GAGAGCCGCTCGGTGGTCATT	0.667000													12	22					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr22:42538870A>C	ENST00000424775.1	-	0	440				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													5	45					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188225462	188225462	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr2:188225462G>C	ENST00000409998.1	-	11	1425	c.644C>G	c.(643-645)tCc>tGc	p.S215C	CALCRL_ENST00000392370.3_Missense_Mutation_p.S215C|AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000410068.1_Missense_Mutation_p.S215C			Q16602	CALRL_HUMAN	calcitonin receptor-like	215						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			AATGAACTGGGACACTTTGCA	0.393000													28	28					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15694388	15694388	+	Silent	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:15694388G>T	ENST00000396368.3	-	25	4916	c.4710C>A	c.(4708-4710)ctC>ctA	p.L1570L	KIAA0430_ENST00000551742.1_Silent_p.L1570L|KIAA0430_ENST00000548025.1_Silent_p.L1567L|KIAA0430_ENST00000602337.1_Silent_p.L1567L|KIAA0430_ENST00000540441.2_Silent_p.L1405L|KIAA0430_ENST00000344181.3_Silent_p.L1258L	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1569						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TGGCAGGGGAGAGACTGAGTG	0.562000													19	95					2.4624e-09	2.73985e-09	1	1	0
KLHL34	257240	broad.mit.edu	37	X	21675273	21675273	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chrX:21675273G>T	ENST00000379499.2	-	1	1175	c.634C>A	c.(634-636)Cgc>Agc	p.R212S		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	212	BACK.									cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						TGTGCCAGGCGCTCAGTTGTG	0.692000													18	7					1.02788e-11	1.17685e-11	1	1	0
ALG1L2	644974	broad.mit.edu	37	3	129817144	129817144	+	RNA	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:129817144G>T	ENST00000507643.1	+	0	726							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										TGCGGGAGTCGCAGCAGCTCT	0.527000													4	67					0.150653	0.150653	1	1	0
HEPACAM	220296	broad.mit.edu	37	11	124794758	124794758	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr11:124794758C>T	ENST00000298251.4	-	2	698	c.293G>A	c.(292-294)cGt>cAt	p.R98H		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	98	Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane		p.R98H(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GAGTCGGATACGGTCTCGATA	0.587000													56	82					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72664015	72664015	+	RNA	SNP	C	C	G			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:72664015C>G	ENST00000425256.1	-	0	885					NR_002164.1																						ATACCACCCCCGGGGCATGCC	0.507000													3	21					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E|FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													4	171					0	0	1	0	0
CCDC106	29903	broad.mit.edu	37	19	56160925	56160925	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr19:56160925C>T	ENST00000586790.1	+	3	1192	c.288C>T	c.(286-288)ttC>ttT	p.F96F	CCDC106_ENST00000308964.3_Silent_p.F96F|CCDC106_ENST00000591241.1_Silent_p.F61F|CCDC106_ENST00000588740.1_Silent_p.F96F|CCDC106_ENST00000591578.1_Silent_p.F96F			Q9BWC9	CC106_HUMAN	coiled-coil domain containing 106	96						nucleus				endometrium(2)|large_intestine(3)|lung(5)|skin(1)	11		Colorectal(82;0.00403)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TGGACAAATTCATCTCTTCTG	0.607000													15	27					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68228053	68228053	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr14:68228053C>A	ENST00000555452.1	-	35	6754	c.6618G>T	c.(6616-6618)caG>caT	p.Q2206H	ZFYVE26_ENST00000557306.1_Intron|ZFYVE26_ENST00000347230.4_Intron			Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	0					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AAGGCAGGCACTGCCTTTTTG	0.552000													7	12					0.0293803	0.029757	1	1	0
TMTC4	84899	broad.mit.edu	37	13	101320926	101320926	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr13:101320926C>T	ENST00000342624.5	-	3	384	c.126G>A	c.(124-126)aaG>aaA	p.K42K	TMTC4_ENST00000376234.3_Silent_p.K23K|TMTC4_ENST00000328767.5_Silent_p.K23K	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	23						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCACTACTAACTTAGCCCAGA	0.453000													18	34					0	0	1	0	0
ALG1L2	644974	broad.mit.edu	37	3	129817138	129817138	+	RNA	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:129817138G>A	ENST00000507643.1	+	0	720							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										AGAACCTGCGGGAGTCGCAGC	0.522000													4	68					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69383522	69383522	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:69383522C>T	ENST00000564737.1	-	2	222	c.223G>A	c.(223-225)Gca>Aca	p.A75T	TMED6_ENST00000288025.3_Silent_p.R82R|RP11-343C2.9_ENST00000563634.1_Intron																							CAGCAACATGCCGGTCATGTG	0.532000													4	155					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45861590	45861590	+	Missense_Mutation	SNP	G	G	A	rs145895219		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr21:45861590G>A	ENST00000397928.1	+	32	4847	c.4402G>A	c.(4402-4404)Gac>Aac	p.D1468N	TRPM2_ENST00000397932.2_Missense_Mutation_p.D1518N|TRPM2_ENST00000300482.5_Missense_Mutation_p.D1468N|TRPM2_ENST00000300481.9_Missense_Mutation_p.D1414N|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1468	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GCACGCCTGCGACTCGGGGGC	0.662000													24	26					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71247374	71247374	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:71247374G>A	ENST00000318789.4	-	6	684	c.159C>T	c.(157-159)caC>caT	p.H53H	FOXP1_ENST00000468577.1_Silent_p.H53H|FOXP1_ENST00000475937.1_Silent_p.H53H|FOXP1_ENST00000493089.1_Silent_p.H53H|FOXP1_ENST00000484350.1_Silent_p.H53H|FOXP1_ENST00000318779.3_Silent_p.H53H|FOXP1_ENST00000498215.1_Silent_p.H53H	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	53					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCTGCTGGGCGTGGGCGAGGT	0.612000			T	PAX5	ALL								4	164					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184588531	184588531	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:184588531G>A	ENST00000437079.3	+	21	1843	c.1672G>A	c.(1672-1674)Gat>Aat	p.D558N	VPS8_ENST00000446204.2_Missense_Mutation_p.D556N|VPS8_ENST00000436792.2_Missense_Mutation_p.D556N|VPS8_ENST00000287546.4_Missense_Mutation_p.D558N	NM_001009921.2	NP_001009921.1	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	558							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CCATTATGCAGATCGAGCTCT	0.408000													11	14					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60698020	60698020	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr11:60698020G>T	ENST00000005286.4	+	5	1058	c.905G>T	c.(904-906)cGc>cTc	p.R302L	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R302L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	302						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						ACAGCCGCCCGCCCAGCCCAG	0.607000													110	152					5.10254e-61	6.6082e-61	1	1	0
FRG1	2483	broad.mit.edu	37	4	190864424	190864424	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr4:190864424G>A	ENST00000226798.4	+	2	352	c.130G>A	c.(130-132)Gtt>Att	p.V44I	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	44					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTTGATATTGTTGGTGAGTC	0.313000													37	47					0	0	1	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154527222	154527222	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:154527222C>A	ENST00000292211.4	-	4	656	c.577G>T	c.(577-579)Gag>Tag	p.E193*	UBE2Q1_ENST00000497453.1_5'UTR|UBE2Q1-AS1_ENST00000441613.1_RNA	NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	193							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCAGGCATCTCCTCATCTTCA	0.527000													13	12					0.000151284	0.000159353	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141093256	141093256	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr2:141093256C>A	ENST00000389484.3	-	78	13015	c.12044G>T	c.(12043-12045)gGc>gTc	p.G4015V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4015					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G4015D(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCAGTTGGGGCCATTCAGCTG	0.418000										TSP Lung(27;0.18)			45	55					1.00953e-15	1.20838e-15	1	1	0
NCF1	653361	broad.mit.edu	37	7	74193734	74193734	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:74193734C>T	ENST00000289473.4	+	4	431	c.361C>T	c.(361-363)Cgc>Tgc	p.R121C	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	121	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity	p.R121C(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						CTTCAAGGTGCGCCCTGATGA	0.597000													9	52					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204900	56204900	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr18:56204900G>A	ENST00000361673.3	-	5	2732	c.2519C>T	c.(2518-2520)aCg>aTg	p.T840M	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	840							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGCCAGTTCCGTATCTACAGA	0.398000													22	48					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43936862	43936862	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr20:43936862C>T	ENST00000343694.3	+	2	174	c.102C>T	c.(100-102)gaC>gaT	p.D34D	MATN4_ENST00000342716.4_5'UTR|RBPJL_ENST00000372743.1_Silent_p.D34D|MATN4_ENST00000353917.5_5'UTR|MATN4_ENST00000360607.5_5'UTR|RBPJL_ENST00000372741.3_Silent_p.D34D|MATN4_ENST00000372751.4_5'UTR|MATN4_ENST00000537548.1_5'UTR	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	34					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				GCGAAGCCGACAGGCGGAGCC	0.647000													39	108					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135015258	135015258	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr10:135015258C>T	ENST00000304613.3	+	17	3264	c.3243C>T	c.(3241-3243)ccC>ccT	p.P1081P	KNDC1_ENST00000368571.2_Silent_p.P1016P|KNDC1_ENST00000368572.2_Silent_p.P1083P			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1081					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTTGTCCCCCGGCCCAGCCG	0.697000													13	16					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223396790	223396790	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:223396790G>A	ENST00000343846.3	-	7	1878	c.1245C>T	c.(1243-1245)ccC>ccT	p.P415P	SUSD4_ENST00000454695.2_Silent_p.P255P|SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000366878.4_Silent_p.P415P			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	415						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CCCCTGAGCCGGGGTATGCTG	0.637000													11	29					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8671394	8671394	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:8671394C>A	ENST00000317371.4	-	14	1703	c.478G>T	c.(478-480)Ggg>Tgg	p.G160W	SSUH2_ENST00000341795.3_Missense_Mutation_p.G160W|SSUH2_ENST00000415132.1_Missense_Mutation_p.G160W|SSUH2_ENST00000544814.1_Missense_Mutation_p.G182W					ssu-2 homolog (C. elegans)																		CGCCCACGCCCATGGCATTTG	0.582000													63	52					5.80444e-35	7.27858e-35	1	1	0
KIAA0195	9772	broad.mit.edu	37	17	73481511	73481511	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr17:73481511C>T	ENST00000314256.7	+	3	421	c.27C>T	c.(25-27)ggC>ggT	p.G9G	KIAA0195_ENST00000375248.5_Silent_p.G19G|KIAA0195_ENST00000579208.1_Intron	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	9					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTGCAGGGCGAGCCTCCCT	0.677000													4	109					0	0	1	0	0
PROSC	11212	broad.mit.edu	37	8	37623065	37623065	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr8:37623065C>T	ENST00000328195.3	+	2	188	c.121C>T	c.(121-123)Cgg>Tgg	p.R41W		NM_007198.3	NP_009129.1	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog (bacterial)	41							pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	CATCCAGCCCCGGCTAGTGGC	0.532000													6	473					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114269973	114269973	+	Silent	SNP	A	A	G	rs149757187		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:114269973A>G	ENST00000393500.3	+	11	1105	c.285A>G	c.(283-285)caA>caG	p.Q95Q	FOXP2_ENST00000378237.3_Silent_p.Q170Q|FOXP2_ENST00000350908.4_Silent_p.Q170Q|FOXP2_ENST00000390668.3_Silent_p.Q194Q|FOXP2_ENST00000360232.4_Silent_p.Q170Q|FOXP2_ENST00000393491.3_Silent_p.Q78Q|FOXP2_ENST00000393498.2_Silent_p.Q150Q|FOXP2_ENST00000393494.2_Silent_p.Q170Q|FOXP2_ENST00000408937.3_Silent_p.Q195Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393489.3_Silent_p.Q78Q|FOXP2_ENST00000403559.4_Silent_p.Q187Q			O15409	FOXP2_HUMAN	forkhead box P2	170	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcagcagcaacaacaacaac	0.502000													5	73					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18547728	18547728	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr18:18547728C>T	ENST00000399799.1	-	26	4117	c.3177G>A	c.(3175-3177)ctG>ctA	p.L1059L		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	1059					actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					GCATGTCATTCAGTTCCTTCT	0.338000													81	174					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791509	60791509	+	Silent	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr20:60791509G>A	ENST00000340177.5	-	3	1175	c.891C>T	c.(889-891)ggC>ggT	p.G297G	HRH3_ENST00000317393.6_Silent_p.G297G	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	297	Poly-Gly.				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CCACGGAGCCGCCCCCACCGC	0.741000													8	1					0	0	1	0	0
SMC1A	8243	broad.mit.edu	37	X	53423264	53423264	+	Silent	SNP	A	A	G			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chrX:53423264A>G	ENST00000322213.4	-	18	2872	c.2745T>C	c.(2743-2745)atT>atC	p.I915I		NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	915					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						GCTTGGTCTCAATGGCTGTCA	0.507000													67	6					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72991587	72991587	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:72991587G>A	ENST00000268489.5	-	2	3130	c.2458C>T	c.(2458-2460)Cgc>Tgc	p.R820C	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	820					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ATGTGAATGCGGAGGTTCCTG	0.567000													79	118					0	0	1	0	0
ALG1L2	644974	broad.mit.edu	37	3	129817127	129817127	+	RNA	SNP	A	A	C			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:129817127A>C	ENST00000507643.1	+	0	709							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CCAGTTCCGGAAGAACCTGCG	0.522000													4	76					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121196183	121196183	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr10:121196183C>T	ENST00000392870.2	+	9	1088	c.759C>T	c.(757-759)taC>taT	p.Y253Y	GRK5_ENST00000369108.3_Silent_p.Y148Y	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	253	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CCTATGCCTACGAGACCAAGG	0.562000													5	48					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216258155	216258155	+	Silent	SNP	C	C	T			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:216258155C>T	ENST00000366943.2	-	25	5438	c.5052G>A	c.(5050-5052)ccG>ccA	p.P1684P	RP11-22M7.2_ENST00000446411.1_RNA|USH2A_ENST00000307340.3_Silent_p.P1684P|RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000442606.1_RNA|RP11-22M7.2_ENST00000430890.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1684	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAATAGCTGACGGATTGTAAT	0.393000										HNSCC(13;0.011)			15	77					0	0	1	0	0
CEP89	84902	broad.mit.edu	37	19	33444543	33444543	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr19:33444543T>C	ENST00000305768.4	-	4	558	c.470A>G	c.(469-471)tAc>tGc	p.Y157C	CEP89_ENST00000590597.1_Missense_Mutation_p.Y157C	NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	157						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						TGGCACAGCGTACAGGTCATC	0.488000													13	693					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22604998	22604998	+	Splice_Site	SNP	A	A	G			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr19:22604998A>G	ENST00000357774.5	-	1	150	c.30_splice	c.e1+1	p.M10_splice	ZNF98_ENST00000601553.1_Splice_Site_p.M10_splice	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CACTCTCACCATTTCTAGGCT	0.607000													53	134					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186823502	186823502	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr1:186823502delC	ENST00000367466.3	+	2	168	c.16delC	c.(16-18)ctfs	p.P6fs	PLA2G4A_ENST00000442353.2_Frame_Shift_Del_p.P6fs|PLA2G4A_ENST00000466600.1_3'UTR	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	6	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATTTATAGATCCTTACCAGCA	0.343													29	34	---	---	---	---					
GFPT1	2673	broad.mit.edu	37	2	69614196	69614196	+	Splice_Site	DEL	C	C	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr2:69614196delC	ENST00000357308.4	-	1	186		c.e1+1		GFPT1_ENST00000494201.1_Splice_Site|GFPT1_ENST00000361060.4_Splice_Site	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1						dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						GGCCCCCTTACCACACATGAT	0.736													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													4	9	---	---	---	---					
GRID2	2895	broad.mit.edu	37	4	94377041	94377041	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr4:94377041delC	ENST00000282020.4	+	11	2032	c.1774delC	c.(1774-1776)ccfs	p.P593fs	GRID2_ENST00000510992.1_Frame_Shift_Del_p.P498fs	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	593					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTGGCTTAATCCCCCACGATT	0.453													40	73	---	---	---	---					
CLINT1	9685	broad.mit.edu	37	5	157216481	157216485	+	Frame_Shift_Del	DEL	GGCAA	GGCAA	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr5:157216481_157216485delGGCAA	ENST00000523094.1	-	11	1622_1626	c.1417_1421delTTGCC	c.(1417-1422)cfs	p.LP473fs	CLINT1_ENST00000411809.2_Frame_Shift_Del_p.LP473fs|CLINT1_ENST00000296951.5_Frame_Shift_Del_p.LP473fs|CLINT1_ENST00000530742.1_Frame_Shift_Del_p.LP473fs|CLINT1_ENST00000523908.1_Frame_Shift_Del_p.LP491fs	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	473					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAAGTAGAGGGCAAGGTTTTGCTG	0.439													52	105	---	---	---	---					
GTF2IRD1P1	729156	broad.mit.edu	37	7	66304731	66304731	+	RNA	DEL	T	T	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr7:66304731delT	ENST00000457166.1	-	0	189					NR_003934.1																						TTTCTTTCCCttttttttttt	0.512													4	8	---	---	---	---					
UBXN8	7993	broad.mit.edu	37	8	30612473	30612474	+	RNA	INS	-	-	T	rs34741520		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr8:30612473_30612474insT	ENST00000519246.1	+	0	604							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						GGGGTTGGTCGttttttttttt	0.391													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96415908	96415918	+	RNA	DEL	TTTTTTTTTTT	TTTTTTTTTTT	-	rs59279759		TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr8:96415908_96415918delTTTTTTTTTTT	ENST00000521905.1	+	0	126																											aataaaAGACttttttttttttttttttttt	0.322													3	6	---	---	---	---					
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr11:281553_281555delGAG	ENST00000534750.1	+	4	2024_2026	c.1819_1821delGAG	c.(1819-1821)del	p.E611del	NLRP6_ENST00000312165.5_In_Frame_Del_p.E611del	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.670													7	173	---	---	---	---					
RP11-160C18.2	0	broad.mit.edu	37	15	79023175	79023175	+	RNA	DEL	C	C	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr15:79023175delC	ENST00000568337.1	+	0	31																											GGTGCAGTGACCCTGCAGGCC	0.537													2	4	---	---	---	---					
CCNF	899	broad.mit.edu	37	16	2481177	2481177	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr16:2481177delA	ENST00000397066.4	+	2	151	c.63delA	c.(61-63)cgfs	p.R22fs		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	22					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				CTACAAAGCGAAGAATAAGGA	0.443													46	80	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chr19:43969653_43969655delAGC	ENST00000244333.3	-	1	157_159	c.69_71delGCT	c.(67-72)ctt>ct	p.LL23del		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	23						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	235	---	---	---	---					
USP9X	8239	broad.mit.edu	37	X	41060380	41060380	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HD-A634-01A-11D-A28R-08	TCGA-HD-A634-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e12e6ab-b2a4-4bcc-bc70-f0432bd57b86	cb781355-b159-46e4-9f27-c4a3e5113845	g.chrX:41060380delG	ENST00000324545.7	+	31	5304	c.4671delG	c.(4669-4671)gtfs	p.V1557fs	USP9X_ENST00000378308.2_Frame_Shift_Del_p.V1557fs	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1557					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						AAGGATTCGTGGGGCTGAAAA	0.463													51	10	---	---	---	---					
