Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF479	90827	broad.mit.edu	37	7	57188621	57188621	+	Silent	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:57188621A>G	ENST00000331162.4	-	5	771	c.501T>C	c.(499-501)ggT>ggC	p.G167G		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TTGAAAATTTACCAAAGACTT	0.299000													8	24					0	0	1	0	0
FAM209B	388799	broad.mit.edu	37	20	55111330	55111330	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:55111330G>A	ENST00000371325.1	+	2	448	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	118						integral to membrane											TACCTTAAACGAACTTGAAGT	0.443000													20	80					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39874633	39874633	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:39874633C>A	ENST00000308559.7	-	10	1496	c.1363G>T	c.(1363-1365)Gcc>Tcc	p.A455S	MOCS1_ENST00000373195.3_Missense_Mutation_p.A368S|MOCS1_ENST00000373175.4_3'UTR|MOCS1_ENST00000373188.2_3'UTR|MOCS1_ENST00000425303.2_Missense_Mutation_p.A471S|MOCS1_ENST00000373186.4_3'UTR|MOCS1_ENST00000340692.5_Missense_Mutation_p.A471S			Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	471	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCTGAGGGGGCAGCAGAAGCC	0.582000													28	80					7.26314e-15	8.15511e-15	1	1	0
LRRC16B	90668	broad.mit.edu	37	14	24529927	24529927	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:24529927G>A	ENST00000342740.5	+	25	2306	c.2152G>A	c.(2152-2154)Gct>Act	p.A718T	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	718										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCTACTCTACGCTCGGGACCT	0.622000													8	20					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127953234	127953234	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:127953234G>A	ENST00000223073.1	-	18	2253	c.2139C>T	c.(2137-2139)tcC>tcT	p.S713S	RBM28_ENST00000481788.1_5'UTR|RBM28_ENST00000415472.2_Silent_p.S572S	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	713					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						TCACCTGCTCGGACGATAATT	0.473000													4	154					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37781744	37781744	+	Silent	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr21:37781744G>T	ENST00000314103.4	+	10	1051	c.900G>T	c.(898-900)ctG>ctT	p.L300L		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	300					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						ACTTTGAACTGAGGCCAGTGG	0.498000													70	139					1.52378e-38	1.81718e-38	1	1	0
METTL10	399818	broad.mit.edu	37	10	126448978	126448978	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr10:126448978T>C	ENST00000494792.1	-	6	604	c.605A>G	c.(604-606)gAg>gGg	p.202_202insG	METTL10_ENST00000368836.2_3'UTR																							AGAAAAAGTCTCACATTTTTT	0.403000													19	15					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55702954	55702954	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:55702954C>A	ENST00000301532.3	-	1	922	c.923G>T	c.(922-924)aGa>aTa	p.R308I		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TACCTTTGATCTTAGAACTTT	0.343000													7	20					5.18039e-06	5.3475e-06	1	1	0
EIF1AX	1964	broad.mit.edu	37	X	20156731	20156731	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:20156731C>T	ENST00000379607.5	-	2	229	c.26G>A	c.(25-27)gGt>gAt	p.G9D	EIF1AX_ENST00000379593.1_Intron	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	9						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TCTGTTTTTACCTCCTTTACC	0.313000													36	9					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18368670	18368670	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr22:18368670C>T	ENST00000441493.2	-	16	2567	c.2215G>A	c.(2215-2217)Gca>Aca	p.A739T	MICAL3_ENST00000400561.2_Missense_Mutation_p.A739T|MICAL3_ENST00000383094.3_Missense_Mutation_p.A739T|MICAL3_ENST00000585038.1_Missense_Mutation_p.A739T|MICAL3_ENST00000414725.2_Missense_Mutation_p.A739T|MICAL3_ENST00000207726.7_Missense_Mutation_p.A739T|MICAL3_ENST00000429452.1_Missense_Mutation_p.A739T|MICAL3_ENST00000444520.1_Missense_Mutation_p.A739T	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	739						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ATGGACTGTGCGGGCGCATTC	0.542000													4	139					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201499611	201499611	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:201499611G>A	ENST00000374700.2	+	21	2560	c.2319G>A	c.(2317-2319)gtG>gtA	p.V773V	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	773					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ATGTCTACGTGTCCACACAGT	0.418000													20	70					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92920295	92920295	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:92920295T>A	ENST00000532405.1	+	11	1158	c.932T>A	c.(931-933)aTt>aAt	p.I311N	SLC24A4_ENST00000531433.1_Missense_Mutation_p.I292N|SLC24A4_ENST00000556739.1_3'UTR|SLC24A4_ENST00000393265.2_Missense_Mutation_p.I247N|SLC24A4_ENST00000351924.5_Missense_Mutation_p.I275N|SLC24A4_ENST00000298877.1_Missense_Mutation_p.I294N			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	311						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GTGGACGAGATTATGAGCTCC	0.532000													10	62					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56649288	56649288	+	Nonsense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:56649288A>T	ENST00000394672.3	+	12	1769	c.1699A>T	c.(1699-1701)Aaa>Taa	p.K567*	CCDC66_ENST00000326595.7_Nonsense_Mutation_p.K533*|CCDC66_ENST00000436465.2_Nonsense_Mutation_p.K567*	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	567										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TAGACTGATTAAAAATCTTGG	0.368000													25	32					0	0	1	0	0
CIR1	9541	broad.mit.edu	37	2	175213705	175213705	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:175213705C>G	ENST00000342016.3	-	10	965	c.873G>C	c.(871-873)agG>agC	p.R291S	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	291	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						ttcttttcttcctttgtattt	0.383000													21	59					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247053320	247053320	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:247053320C>A	ENST00000366508.1	-	17	2333	c.2197G>T	c.(2197-2199)Gta>Tta	p.V733L	AHCTF1_ENST00000391829.2_Missense_Mutation_p.V698L|AHCTF1_ENST00000326225.3_Missense_Mutation_p.V707L|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	698	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCTGAATTACAGGGTAGTTG	0.338000													35	96					7.91308e-09	8.34786e-09	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89348160	89348160	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:89348160C>T	ENST00000301030.4	-	9	5250	c.4790G>A	c.(4789-4791)cGc>cAc	p.R1597H	ANKRD11_ENST00000378330.2_Missense_Mutation_p.R1597H	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1597	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCGCTTGTGGCGCTCCTCGAT	0.622000													4	135					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552979	117552979	+	Missense_Mutation	SNP	C	C	T	rs144487361		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr9:117552979C>T	ENST00000374045.4	-	4	622	c.509G>A	c.(508-510)cGa>cAa	p.R170Q	TNFSF15_ENST00000374044.1_Missense_Mutation_p.R93Q	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	170					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						CTTGTTTGGTCGGCCTGCTTG	0.522000													3	33					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33044516	33044516	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr21:33044516G>A	ENST00000286835.7	-	20	3022	c.2640C>T	c.(2638-2640)ccC>ccT	p.P880P	SCAF4_ENST00000434667.3_Silent_p.P865P|SCAF4_ENST00000399804.1_Silent_p.P858P	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	880						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GCGGTGGCATGGGACGGGGCG	0.652000													29	56					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900553	133900553	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:133900553C>T	ENST00000220616.4	+	10	2541	c.2501C>T	c.(2500-2502)cCg>cTg	p.P834L	TG_ENST00000377869.1_Missense_Mutation_p.P834L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	834	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GATGTCTTCCCGGTGCTGTCA	0.522000													34	54					0	0	1	0	0
ACTR6	64431	broad.mit.edu	37	12	100601474	100601474	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:100601474G>A	ENST00000188312.2	+	4	1054	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	ACTR6_ENST00000551617.1_Missense_Mutation_p.E15K|ACTR6_ENST00000552376.1_Missense_Mutation_p.E97K|ACTR6_ENST00000546902.1_Missense_Mutation_p.E15K	NM_022496.4	NP_071941.1	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog (yeast)	97						cytoplasm|cytoskeleton				autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14						TATTATCACTGAACCATACTT	0.259000													12	20					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72432954	72432954	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:72432954C>A	ENST00000373517.3	-	1	1730	c.1375G>T	c.(1375-1377)Gat>Tat	p.D459Y	NAP1L2_ENST00000536638.1_Missense_Mutation_p.D317Y	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	459					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CTCTAACGATCAATGTCTTCT	0.348000													16	15					1.3612e-06	1.41271e-06	1	1	0
C9orf3	84909	broad.mit.edu	37	9	97522357	97522357	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr9:97522357G>A	ENST00000375315.2	+	1	292	c.292G>A	c.(292-294)Gat>Aat	p.D98N	C9orf3_ENST00000297979.5_Missense_Mutation_p.D98N|C9orf3_ENST00000277198.2_Missense_Mutation_p.D98N	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	98					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GGAATATAATGATTTTGCAAT	0.398000													80	81					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553483	113553483	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:113553483C>T	ENST00000546530.1	-	11	1245	c.960G>A	c.(958-960)ggG>ggA	p.G320G	RASAL1_ENST00000548055.1_Silent_p.G320G|RASAL1_ENST00000261729.5_Silent_p.G320G|RASAL1_ENST00000446861.3_Silent_p.G320G|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	320	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						CCAGAAAGCGCCCAGCCAGTC	0.632000													15	19					0	0	1	0	0
ZNF85	7639	broad.mit.edu	37	19	21132403	21132403	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:21132403G>T	ENST00000601023.1	+	2	1552	c.906G>T	c.(904-906)gaG>gaT	p.E302D	ZNF85_ENST00000328178.8_Missense_Mutation_p.E361D|ZNF85_ENST00000345030.6_Missense_Mutation_p.E328D			Q03923	ZNF85_HUMAN	zinc finger protein 85	361						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						CCACACATGAGGTAATTCATA	0.358000													16	27					4.7546e-09	5.07158e-09	1	1	0
ME2	4200	broad.mit.edu	37	18	48439269	48439269	+	Missense_Mutation	SNP	C	C	T	rs16952692		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr18:48439269C>T	ENST00000321341.5	+	4	613	c.341C>T	c.(340-342)cCg>cTg	p.P114L	ME2_ENST00000382927.3_Missense_Mutation_p.P114L	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	114			P -> L (in dbSNP:rs16952692).		malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GTATATACACCGACGGTTGGT	0.328000													25	52					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583252	119583252	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:119583252G>T	ENST00000267260.4	+	9	1226	c.838G>T	c.(838-840)Gga>Tga	p.G280*		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	280	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CACCTCGCGAGGACGTTCCCA	0.607000													6	16					3.59834e-05	3.69455e-05	1	1	0
MKRN2	23609	broad.mit.edu	37	3	12623356	12623356	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:12623356G>T	ENST00000170447.7	+	7	1155	c.1018G>T	c.(1018-1020)Gga>Tga	p.G340*	MKRN2_ENST00000411987.1_Nonsense_Mutation_p.G297*|MKRN2_ENST00000448482.1_Nonsense_Mutation_p.G338*	NM_001271707.1|NM_014160.3	NP_001258636.1|NP_054879.3	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	340						intracellular	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)	16						CTGCCCATTTGGAAGCAAATG	0.498000													11	104					0.000673444	0.000687773	1	1	0
FRAS1	80144	broad.mit.edu	37	4	79400835	79400835	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:79400835C>T	ENST00000264895.6	+	56	8846	c.8406C>T	c.(8404-8406)tcC>tcT	p.S2802S		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2797	Calx-beta 3.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CGACTGTGTCCCTGGGCAACA	0.532000													12	24					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100403871	100403871	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:100403871G>T	ENST00000395996.1	+	21	3132	c.3021G>T	c.(3019-3021)aaG>aaT	p.K1007N	VPS13B_ENST00000357162.2_Missense_Mutation_p.K1007N|VPS13B_ENST00000358544.2_Missense_Mutation_p.K1007N			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1007					protein transport			p.K1007K(2)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTTGGCAAAGCAGCAATCAT	0.453000													46	60					6.21074e-16	7.09799e-16	1	1	0
MOCS1	4337	broad.mit.edu	37	6	39874632	39874632	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:39874632G>A	ENST00000308559.7	-	10	1497	c.1364C>T	c.(1363-1365)gCc>gTc	p.A455V	MOCS1_ENST00000373195.3_Missense_Mutation_p.A368V|MOCS1_ENST00000373175.4_3'UTR|MOCS1_ENST00000373188.2_3'UTR|MOCS1_ENST00000425303.2_Missense_Mutation_p.A471V|MOCS1_ENST00000373186.4_3'UTR|MOCS1_ENST00000340692.5_Missense_Mutation_p.A471V			Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	471	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					TCCTGAGGGGGCAGCAGAAGC	0.582000													28	81					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168067319	168067319	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:168067319C>T	ENST00000409195.1	+	4	726	c.637C>T	c.(637-639)Ctc>Ttc	p.L213F	XIRP2_ENST00000409756.2_Missense_Mutation_p.L213F|XIRP2_ENST00000409273.1_5'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.L246F|XIRP2_ENST00000409043.1_Missense_Mutation_p.L213F|XIRP2_ENST00000409605.1_5'UTR|XIRP2_ENST00000295237.9_Missense_Mutation_p.L213F|XIRP2_ENST00000409728.1_Missense_Mutation_p.L246F	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	38					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGTGTCAGACCTCCACGAAGT	0.562000													37	92					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121970759	121970759	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:121970759A>T	ENST00000377069.4	-	8	1196	c.790T>A	c.(790-792)Tgc>Agc	p.C264S	KDM2B_ENST00000543852.1_Missense_Mutation_p.C64S|KDM2B_ENST00000538046.2_Intron|KDM2B_ENST00000536437.1_Missense_Mutation_p.C178S|KDM2B_ENST00000377071.4_Missense_Mutation_p.C295S	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	295	JmjC.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						ATTCTTTGGCATCGTTCCACA	0.552000													32	28					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53069019	53069019	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:53069019G>A	ENST00000252244.3	-	9	1951	c.1893C>T	c.(1891-1893)agC>agT	p.S631S		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	631	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CAAACTTCACGCTGGAACTGC	0.562000													44	133					0	0	1	0	0
GSTM4	2948	broad.mit.edu	37	1	110199045	110199045	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:110199045G>A	ENST00000369836.4	+	1	343	c.34G>A	c.(34-36)Ggg>Agg	p.G12R	GSTM4_ENST00000336075.5_Missense_Mutation_p.G12R|GSTM4_ENST00000369833.1_5'UTR|GSTM4_ENST00000495742.1_3'UTR|GSTM4_ENST00000326729.5_Missense_Mutation_p.G12R	NM_000850.4	NP_000841.1	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4	12	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GGACATCCGCGGGGTGAGTGA	0.652000													27	109					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869953	174869953	+	Missense_Mutation	SNP	C	C	G	rs5330		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr5:174869953C>G	ENST00000393752.2	-	2	1142	c.150G>C	c.(148-150)agG>agC	p.R50S		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	50			R -> S (in dbSNP:rs5330).		activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GGTGTCGGAACCTGATAACGG	0.572000													19	68					0	0	1	0	0
PAPSS1	9061	broad.mit.edu	37	4	108566209	108566209	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:108566209G>C	ENST00000265174.4	-	10	1527	c.1255C>G	c.(1255-1257)Caa>Gaa	p.Q419E		NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	419					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		TTGCGTAGTTGAAATGCAAAG	0.433000													15	42					0	0	1	0	0
SUFU	51684	broad.mit.edu	37	10	104309846	104309846	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr10:104309846G>T	ENST00000369902.3	+	3	603	c.437G>T	c.(436-438)cGa>cTa	p.R146L	SUFU_ENST00000369899.2_Missense_Mutation_p.R146L|SUFU_ENST00000423559.2_Missense_Mutation_p.R146L	NM_016169.3	NP_057253.2	Q9UMX1	SUFU_HUMAN	suppressor of fused homolog (Drosophila)	146					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			breast(2)|central_nervous_system(7)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	24		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		GGCTTGGCACGATACGTGTTC	0.527000			"""D, F, S"""		medulloblastoma	medulloblastoma			Medulloblastoma, associated with Germline SUFU Mutation				19	43					1.01871e-10	1.11132e-10	1	1	0
KIF16B	55614	broad.mit.edu	37	20	16359864	16359864	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:16359864A>C	ENST00000354981.2	-	19	2940	c.2783T>G	c.(2782-2784)tTt>tGt	p.F928C	KIF16B_ENST00000355755.3_Missense_Mutation_p.F928C|KIF16B_ENST00000378003.2_Missense_Mutation_p.F154C|KIF16B_ENST00000408042.1_Missense_Mutation_p.F928C	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	928	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						AAGAATTTCAAATGCTCTCTG	0.438000													22	91					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444508	20444508	+	Silent	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:20444508A>T	ENST00000305051.5	+	1	906	c.831A>T	c.(829-831)ccA>ccT	p.P277P		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTTGGACCATGCATTTTCA	0.438000													27	76					0	0	1	0	0
BMF	90427	broad.mit.edu	37	15	40398126	40398126	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:40398126G>A	ENST00000354670.4	-	3	396	c.162C>T	c.(160-162)caC>caT	p.H54H	BMF_ENST00000431415.3_Silent_p.H54H|BMF_ENST00000558774.1_Silent_p.H54H|BMF_ENST00000397573.1_Silent_p.H54H|BMF_ENST00000220446.4_Silent_p.H54H|BMF_ENST00000559701.1_Silent_p.H54H|BMF_ENST00000561282.1_Silent_p.H54H|BMF_ENST00000561360.1_Silent_p.H54H	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	54					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		GGCCACAGCAGTGGGTGAGAG	0.637000													21	63					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4443689	4443689	+	Missense_Mutation	SNP	G	G	A	rs138042708		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:4443689G>A	ENST00000254718.4	-	25	3694	c.3388C>T	c.(3388-3390)Cgc>Tgc	p.R1130C	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.R1130C			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	1130					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						TCGTGCAGGCGGCTGGAGCCG	0.642000													3	42					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43911887	43911887	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:43911887G>A	ENST00000562955.1	+	63	8783	c.8783G>A	c.(8782-8784)cGg>cAg	p.R2928Q	SZT2_ENST00000372442.1_Missense_Mutation_p.R2086Q	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2985						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CACCTGCAGCGGGCACTGCCT	0.577000													4	148					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53481001	53481001	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:53481001T>C	ENST00000262133.6	+	4	757	c.620T>C	c.(619-621)cTt>cCt	p.L207P	RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	207					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TGTTGGGTGCTTTTTATATAT	0.284000													4	34					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962546	34962546	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:34962546G>A	ENST00000329357.5	+	1	1634	c.1598G>A	c.(1597-1599)cGg>cAg	p.R533Q		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	533										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AGGAGACGCCGGGCGGCACCG	0.502000													38	17					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49000548	49000548	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:49000548T>G	ENST00000226432.4	+	6	968	c.785T>G	c.(784-786)tTg>tGg	p.L262W	CWH43_ENST00000513409.1_Missense_Mutation_p.L235W	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	262					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GGTACTGGTTTGATCTGGTGG	0.458000													13	88					0	0	1	0	0
THBD	7056	broad.mit.edu	37	20	23028618	23028618	+	Silent	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:23028618C>A	ENST00000377103.2	-	1	1760	c.1524G>T	c.(1522-1524)ccG>ccT	p.P508P		NM_000361.2	NP_000352.1	P07204	TRBM_HUMAN	thrombomodulin	508					blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	GCCCCACGGCCGGAGGAGTCA	0.682000													24	11					6.21321e-17	7.18637e-17	1	1	0
HOXD3	3232	broad.mit.edu	37	2	177036368	177036368	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:177036368C>A	ENST00000468418.3	+	4	2755	c.665C>A	c.(664-666)cCg>cAg	p.P222Q	HOXD3_ENST00000249440.3_Missense_Mutation_p.P222Q|HOXD3_ENST00000410016.1_Missense_Mutation_p.P222Q			P31249	HXD3_HUMAN	homeobox D3	222					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		TTGTGCCGGCCGCGCCGCGTG	0.597000													24	142					1.10923e-09	1.20323e-09	1	1	0
HAUS5	23354	broad.mit.edu	37	19	36109507	36109507	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:36109507C>T	ENST00000203166.5	+	12	947	c.922C>T	c.(922-924)Cgg>Tgg	p.R308W	HAUS5_ENST00000379045.2_Silent_p.S286S	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	308					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						GGTCTCCCAGCGGAGCACCCT	0.642000													49	108					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158619721	158619721	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:158619721C>T	ENST00000368148.3	-	25	3674	c.3494G>A	c.(3493-3495)tGg>tAg	p.W1165*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.W1165*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1165					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAAAGAACCCCAGCGGGAATT	0.448000													4	13					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717515	142717515	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:142717515G>A	ENST00000381779.4	-	2	1635	c.1410C>T	c.(1408-1410)gaC>gaT	p.D470D	SLITRK4_ENST00000338017.4_Silent_p.D470D|SLITRK4_ENST00000356928.1_Silent_p.D470D	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	470						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTGGCATGGAGTCAAAGGTGC	0.393000													31	16					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													4	91					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138762838	138762838	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:138762838G>A	ENST00000413199.1	-	1	896	c.625C>T	c.(625-627)Cgc>Tgc	p.R209C	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.R209C	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	209	Pro-rich.									breast(2)|lung(7)|skin(2)	11						CGTGGAGAGCGTCTCTCTGAA	0.637000													9	21					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21038387	21038387	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:21038387G>A	ENST00000261383.3	-	38	5501	c.5502C>T	c.(5500-5502)ccC>ccT	p.P1834P	DNAH3_ENST00000415178.1_Silent_p.P1834P	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1834	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CGAGGTCGGCGGGCTCGAAGA	0.567000													14	22					0	0	1	0	0
ODF3L1	161753	broad.mit.edu	37	15	76019675	76019675	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:76019675C>A	ENST00000332145.2	+	4	842	c.619C>A	c.(619-621)Cct>Act	p.P207T		NM_175881.3	NP_787077.1	Q8IXM7	OD3L1_HUMAN	outer dense fiber of sperm tails 3-like 1	207										kidney(1)|lung(1)	2						GTACGCCCGACCTGAGCCATC	0.632000													20	63					8.34094e-07	8.70359e-07	1	1	0
NT5C3B	115024	broad.mit.edu	37	17	39983815	39983815	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:39983815C>A	ENST00000269534.8	-	8	708	c.607G>T	c.(607-609)Gag>Tag	p.E203*	NT5C3B_ENST00000435506.2_Nonsense_Mutation_p.E211*|NT5C3B_ENST00000521789.1_Intron	NM_052935.4	NP_443167.4			5'-nucleotidase, cytosolic IIIB																		CCAGAGTTCTCACACGCAGAG	0.502000													68	28					5.41809e-49	6.5017e-49	1	1	0
CDK14	5218	broad.mit.edu	37	7	90528663	90528663	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:90528663G>A	ENST00000406263.1	+	6	1001	c.559G>A	c.(559-561)Gtg>Atg	p.V187M	CDK14_ENST00000380050.3_Missense_Mutation_p.V233M|CDK14_ENST00000436577.2_Missense_Mutation_p.V104M|CDK14_ENST00000265741.3_Missense_Mutation_p.V215M			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	233	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						TCCAGATAATGTGAAGGTAGG	0.358000													4	10					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47310955	47310955	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:47310955G>A	ENST00000342922.4	+	16	3024	c.2667G>A	c.(2665-2667)gcG>gcA	p.A889A	MADD_ENST00000407859.3_Silent_p.A866A|MADD_ENST00000406482.1_Silent_p.A846A|MADD_ENST00000349238.3_Silent_p.A909A|MADD_ENST00000402799.1_Silent_p.A846A|MADD_ENST00000402192.2_Silent_p.A889A|MADD_ENST00000395336.3_Silent_p.A909A|MADD_ENST00000395344.3_Silent_p.A846A|MADD_ENST00000311027.5_Silent_p.A909A	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	909					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		ACAGGAGGGCGTTAGTGGATC	0.488000													5	392					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64077858	64077858	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr5:64077858A>G	ENST00000508024.1	+	3	451	c.250A>G	c.(250-252)Aaa>Gaa	p.K84E	CWC27_ENST00000381070.3_Missense_Mutation_p.K84E			Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	84	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						AGCGCCATTCAAAGTAAGACT	0.363000													11	18					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890308	23890308	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:23890308G>C	ENST00000532292.1	-	1	867	c.773C>G	c.(772-774)gCc>gGc	p.A258G		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGCCTGGGGGGCAGCTGCTGT	0.632000													18	63					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41741077	41741077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr21:41741077G>A	ENST00000400454.1	-	4	1081	c.604C>T	c.(604-606)Cga>Tga	p.R202*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	202	Ig-like C2-type 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCGGTGTATCGATGCCGCGTG	0.428000													15	27					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635586	44635586	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:44635586C>T	ENST00000262894.6	+	5	1099	c.819C>T	c.(817-819)tcC>tcT	p.S273S	ZNF225_ENST00000590612.1_Silent_p.S273S|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				TTCATGATTCCCAGCTTCAGG	0.393000													56	104					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582950	55582950	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr10:55582950T>A	ENST00000361849.3	-	34	4936	c.4542A>T	c.(4540-4542)aaA>aaT	p.K1514N	PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.K1509N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.K1512N|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.K1443N|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.K1489N|PCDH15_ENST00000395432.2_Missense_Mutation_p.K1472N	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1512					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GAAATGTGAATTTTCTTGCAG	0.373000										HNSCC(58;0.16)			23	40					0	0	1	0	0
SLC22A16	85413	broad.mit.edu	37	6	110777855	110777855	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:110777855G>A	ENST00000368919.3	-	2	485	c.419C>T	c.(418-420)gCg>gTg	p.A140V	SLC22A16_ENST00000461487.1_5'UTR|SLC22A16_ENST00000439654.1_Missense_Mutation_p.A140V|SLC22A16_ENST00000456137.2_Missense_Mutation_p.A140V|SLC22A16_ENST00000330550.4_Missense_Mutation_p.A106V	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	140					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CTGGGTCACCGCAGTGCTTTT	0.478000													4	100					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205272827	205272827	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:205272827G>T	ENST00000367157.3	-	7	1764	c.1638C>A	c.(1636-1638)gaC>gaA	p.D546E		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	546					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGGATGCTGTCCTCGCTCA	0.687000													23	66					1.64293e-13	1.82337e-13	1	1	0
TRPC3	7222	broad.mit.edu	37	4	122824075	122824075	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:122824075A>G	ENST00000264811.5	-	8	2594	c.2176T>C	c.(2176-2178)Ttt>Ctt	p.F726L	TRPC3_ENST00000513531.1_Missense_Mutation_p.F671L|TRPC3_ENST00000379645.3_Missense_Mutation_p.F799L	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	714					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CATTTGGGAAAGTTAACAATT	0.368000													3	48					0	0	1	0	0
RRAS	6237	broad.mit.edu	37	19	50139087	50139087	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:50139087G>A	ENST00000246792.3	-	5	578	c.476C>T	c.(475-477)gCc>gTc	p.A159V		NM_006270.3	NP_006261.1	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	159					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(2)	6				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GGCGCCGAAGGCAGAGGCTTC	0.657000													19	28					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196274405	196274405	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:196274405C>A	ENST00000367433.5	-	21	2583	c.2482G>T	c.(2482-2484)Gcc>Tcc	p.A828S	KCNT2_ENST00000294725.8_Missense_Mutation_p.A852S|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Missense_Mutation_p.A778S			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	852						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAGTCTTTGGCTCTGAATTGC	0.363000													5	48					0.014758	0.0148353	1	1	0
ALPP	250	broad.mit.edu	37	2	233245422	233245422	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:233245422C>T	ENST00000392027.2	+	8	1224	c.955C>T	c.(955-957)Cgc>Tgc	p.R319C	AC068134.8_ENST00000439072.1_RNA|AC068134.8_ENST00000441266.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	319						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GGCTGCCCTGCGCCTGCTGAG	0.632000													11	35					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207394	58207394	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr13:58207394C>A	ENST00000377918.3	+	1	740	c.714C>A	c.(712-714)gaC>gaA	p.D238E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	238	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ACTCCAACGACAACAGCCCGG	0.597000													19	62					1.67942e-08	1.76201e-08	1	1	0
MST1	4485	broad.mit.edu	37	3	49723034	49723034	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:49723034C>T	ENST00000449682.2	-	11	1743	c.1382G>A	c.(1381-1383)cGc>cAc	p.R461H	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	447					proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTCACCGCAGCGTCGCAGGGC	0.602000													15	36					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97172889	97172889	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:97172889A>T	ENST00000287020.5	-	1	131	c.32T>A	c.(31-33)gTc>gAc	p.V11D		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	11					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					GATGAGGAAGACGGCCGAGAG	0.667000													27	97					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61026510	61026510	+	Silent	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:61026510T>C	ENST00000335613.5	-	20	2891	c.2505A>G	c.(2503-2505)ccA>ccG	p.P835P	VWCE_ENST00000535710.1_Silent_p.P300P	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	835	Pro-rich.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						CAGGCTCCCCTGGGAAAGTGG	0.597000													38	56					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182141	140182141	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr5:140182141G>A	ENST00000522353.2	+	1	1359	c.1359G>A	c.(1357-1359)ccG>ccA	p.P453P	PCDHA3_ENST00000532566.2_Silent_p.P453P|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAATGCGCCGGCATTCTCGC	0.662000													4	165					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109098191	109098191	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:109098191G>A	ENST00000309863.6	+	10	3813	c.3099G>A	c.(3097-3099)ctG>ctA	p.L1033L		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1033					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						CAGAGCAACTGGATGTGGAAA	0.303000													10	37					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36192435	36192435	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:36192435A>T	ENST00000258840.6	-	15	2292	c.1902T>A	c.(1900-1902)aaT>aaA	p.N634K	RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.N634K|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.N634K|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.N634K			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	634					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGATGTACACATTTAGGTTTG	0.393000													13	33					0	0	1	0	0
B3GAT3	26229	broad.mit.edu	37	11	62384203	62384203	+	Silent	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:62384203G>T	ENST00000531383.1	-	4	890	c.684C>A	c.(682-684)ggC>ggA	p.G228G	B3GAT3_ENST00000534026.1_Silent_p.G228G|B3GAT3_ENST00000265471.5_Silent_p.G228G			O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	228					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)|urinary_tract(1)	12						GTACCTGAGGGCCCTCGAATC	0.652000													12	48					7.03913e-09	7.46692e-09	1	1	0
POSTN	10631	broad.mit.edu	37	13	38164636	38164636	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr13:38164636A>T	ENST00000379747.4	-	4	431	c.314T>A	c.(313-315)cTg>cAg	p.L105Q	POSTN_ENST00000541481.1_Missense_Mutation_p.L105Q|POSTN_ENST00000379742.4_Missense_Mutation_p.L105Q|POSTN_ENST00000379743.4_Missense_Mutation_p.L105Q|POSTN_ENST00000379749.4_Missense_Mutation_p.L105Q|POSTN_ENST00000541179.1_Missense_Mutation_p.L105Q	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	105	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CACGATGCCCAGAGTGCCATA	0.438000													19	9					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213947	102213947	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:102213947A>T	ENST00000520347.1	-	2	2979	c.23T>A	c.(22-24)aTt>aAt	p.I8N	ZNF706_ENST00000521272.1_Missense_Mutation_p.I8N|ZNF706_ENST00000519882.1_Missense_Mutation_p.I8N|ZNF706_ENST00000519744.1_Missense_Mutation_p.I8N|ZNF706_ENST00000520984.1_Missense_Mutation_p.I8N|ZNF706_ENST00000517844.1_Missense_Mutation_p.I8N|ZNF706_ENST00000311212.4_Missense_Mutation_p.I8N|ZNF706_ENST00000518336.1_Missense_Mutation_p.I8N			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	8						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGAGACTGAATTTTCTGCTG	0.393000													9	78					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855241	53855241	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:53855241C>T	ENST00000458035.1	+	4	1430	c.1313C>T	c.(1312-1314)cCt>cTt	p.P438L	ZNF845_ENST00000595091.1_Missense_Mutation_p.P438L	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GGAGAGAAACCTTACAAATGT	0.378000													34	96					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53781384	53781384	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:53781384C>T	ENST00000288139.3	+	27	3401	c.3283C>T	c.(3283-3285)Cgg>Tgg	p.R1095W	CACNA1D_ENST00000422281.2_Missense_Mutation_p.R1075W|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R1075W	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1075	Dihydropyridine binding (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGTCCGTGAACGGATCTGGCA	0.517000													23	72					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166020938	166020938	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:166020938G>A	ENST00000360093.3	-	6	1057	c.566C>T	c.(565-567)cCa>cTa	p.P189L	SCN3A_ENST00000283254.7_Missense_Mutation_p.P189L|SCN3A_ENST00000409101.3_Missense_Mutation_p.P189L	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	189						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CCAGTTCCATGGATCACGAAG	0.378000													14	38					0	0	1	0	0
CDCA7L	55536	broad.mit.edu	37	7	21956456	21956456	+	Silent	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:21956456A>G	ENST00000406877.3	-	2	360	c.81T>C	c.(79-81)gtT>gtC	p.V27V	CDCA7L_ENST00000356195.5_5'UTR|CDCA7L_ENST00000465490.1_5'UTR|CDCA7L_ENST00000373934.4_Silent_p.V27V	NM_018719.4	NP_061189.2	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like	27					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	29						CTCGGAAGCCAACAAACTCTT	0.463000													29	231					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138762753	138762753	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:138762753G>A	ENST00000413199.1	-	1	981	c.710C>T	c.(709-711)cCg>cTg	p.P237L	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.P237L	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	237	Pro-rich.									breast(2)|lung(7)|skin(2)	11						ACCTGGACTCGGAGAGGGAGG	0.627000													5	14					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69521673	69521673	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:69521673C>T	ENST00000341516.5	-	9	1877	c.1730G>A	c.(1729-1731)cGc>cAc	p.R577H	DCAF5_ENST00000556847.1_Missense_Mutation_p.R495H|DCAF5_ENST00000557386.1_Missense_Mutation_p.R576H|DCAF5_ENST00000554215.1_Missense_Mutation_p.R495H	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	577						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						AGAGGCTCGGCGTTCATTCAG	0.582000													10	108					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48637295	48637295	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:48637295G>A	ENST00000263274.7	-	17	1971	c.1552C>T	c.(1552-1554)Ccc>Tcc	p.P518S	LIG1_ENST00000536218.1_Missense_Mutation_p.P450S|LIG1_ENST00000427526.2_Missense_Mutation_p.P487S	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	518					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	AGCAGCACGGGGATAATTCGG	0.632000								Nucleotide excision repair (NER)					3	1					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304133	114304133	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr9:114304133C>T	ENST00000309235.5	+	6	1076	c.918C>T	c.(916-918)ccC>ccT	p.P306P	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	306					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						ATAAAAGCCCCTTTGGACATA	0.393000													56	162					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	C	rs28934573		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:7577559G>C	ENST00000420246.2	-	7	854	c.722C>G	c.(721-723)tCc>tGc	p.S241C	TP53_ENST00000445888.2_Missense_Mutation_p.S241C|TP53_ENST00000455263.2_Missense_Mutation_p.S241C|TP53_ENST00000359597.4_Missense_Mutation_p.S241C|TP53_ENST00000269305.4_Missense_Mutation_p.S241C|TP53_ENST00000413465.2_Missense_Mutation_p.S241C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			49	10					0	0	1	0	0
ADK	132	broad.mit.edu	37	10	76360239	76360239	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr10:76360239A>G	ENST00000372734.3	+	9	1001	c.814A>G	c.(814-816)Ata>Gta	p.I272V	ADK_ENST00000539909.1_Missense_Mutation_p.I232V|ADK_ENST00000286621.2_Missense_Mutation_p.I289V|ADK_ENST00000541550.1_Missense_Mutation_p.I254V	NM_001123.3|NM_001202449.1	NP_001114.2|NP_001189378.1	P55263	ADK_HUMAN	adenosine kinase	289					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			breast(1)|large_intestine(2)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	8	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	AGATGACACTATAATGGCTAC	0.348000													14	22					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129131155	129131155	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:129131155A>T	ENST00000326639.6	+	20	2903	c.2692A>T	c.(2692-2694)Ata>Tta	p.I898L	LARP1B_ENST00000354456.3_Intron|LARP1B_ENST00000264584.5_Missense_Mutation_p.I839L|LARP1B_ENST00000441387.1_3'UTR|LARP1B_ENST00000506199.1_Intron	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	898							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TCAGGTACCAATAAACTCTCC	0.448000													35	325					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48608635	48608635	+	Silent	SNP	A	A	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:48608635A>C	ENST00000354276.3	-	3	402	c.75T>G	c.(73-75)ctT>ctG	p.L25L	PLA2G4C_ENST00000599111.1_Silent_p.L35L|PLA2G4C_ENST00000599921.1_Silent_p.L25L|PLA2G4C_ENST00000413144.2_Silent_p.L25L	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	25	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TCAGCACATGAAGTCTTCGTC	0.517000													97	96					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147561255	147561255	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:147561255C>T	ENST00000281321.3	+	2	773	c.525C>T	c.(523-525)caC>caT	p.H175H		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	175	Poly-His.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					accaccaccaccatcaccacc	0.682000													3	28					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22947044	22947044	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:22947044G>A	ENST00000313077.7	+	13	1442	c.1317G>A	c.(1315-1317)acG>acA	p.T439T	CYFIP1_ENST00000560848.1_Silent_p.T439T	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	439					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		AGCGTGCCACGCGCTACAACT	0.572000													19	128					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25319725	25319725	+	Splice_Site	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:25319725G>T	ENST00000330560.3	+	4	864		c.e4+1		CDCA2_ENST00000380665.3_Splice_Site	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2						cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TCCTTCCCAGGTATGATTTTC	0.413000													10	30					1.11149e-13	1.24073e-13	1	1	0
PCDH1	5097	broad.mit.edu	37	5	141243498	141243498	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr5:141243498G>T	ENST00000287008.3	-	3	2545	c.2398C>A	c.(2398-2400)Ccc>Acc	p.P800T	PCDH1_ENST00000456271.1_Missense_Mutation_p.P788T|PCDH1_ENST00000536585.1_Missense_Mutation_p.P778T|PCDH1_ENST00000503492.1_Intron|PCDH1_ENST00000511044.1_5'UTR|PCDH1_ENST00000394536.3_Missense_Mutation_p.P800T	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	800	Cadherin 7.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TAGCGTGGGGGCTTGCCGCGG	0.617000													36	42					3.86903e-22	4.55738e-22	1	1	0
OR2W1	26692	broad.mit.edu	37	6	29012233	29012233	+	Silent	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:29012233G>C	ENST00000377175.1	-	1	784	c.720C>G	c.(718-720)acC>acG	p.T240T		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						GAGATCCACAGGTATTCATTG	0.438000													35	123					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8717816	8717816	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:8717816G>C	ENST00000378641.3	+	20	2660	c.2185G>C	c.(2185-2187)Gaa>Caa	p.E729Q	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000338037.6_Missense_Mutation_p.E729Q|PLCB1_ENST00000378637.2_Missense_Mutation_p.E729Q	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	729	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TGTCTGGGAAGAAGAACCTAT	0.378000													15	92					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189159	50189159	+	Silent	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:50189159A>T	ENST00000335999.6	-	8	2685	c.2484T>A	c.(2482-2484)ccT>ccA	p.P828P		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	824	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CCCCAGGTCGAGGCACCACCT	0.627000													20	59					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12647528	12647528	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:12647528G>A	ENST00000425538.1	+	8	946	c.746G>A	c.(745-747)cGc>cAc	p.R249H	MYOCD_ENST00000395988.1_Missense_Mutation_p.R153H|MYOCD_ENST00000343344.4_Missense_Mutation_p.R249H	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	249					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGTAAGAACCGCCACAAAAAG	0.473000													14	32					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28909738	28909738	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:28909738T>G	ENST00000395503.4	+	14	1914	c.1730T>G	c.(1729-1731)gTc>gGc	p.V577G	ATP2A1_ENST00000357084.3_Missense_Mutation_p.V577G|ATP2A1_ENST00000536376.1_Missense_Mutation_p.V452G	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	577					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GAGGAAATGGTCCTGGATGAC	0.642000													20	36					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70925552	70925552	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:70925552T>A	ENST00000603540.1	+	2	1594	c.1336T>A	c.(1336-1338)Tgt>Agt	p.C446S	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.C446S	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	446	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGGGCTGCCTGTGCTTTTGG	0.498000													20	58					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	83635273	83635273	+	Silent	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr10:83635273G>C	ENST00000404547.1	+	1	177	c.177G>C	c.(175-177)gtG>gtC	p.V59V	NRG3_ENST00000372141.2_Silent_p.V59V			P56975	NRG3_HUMAN	neuregulin 3	59					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ACTGCATCGTGTGGAACCGGC	0.711000													8	11					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120008774	120008774	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:120008774A>T	ENST00000371311.3	-	1	1005	c.751T>A	c.(751-753)Tca>Aca	p.S251T		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	251										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCCTCCTCTGAGGTCGGTTCC	0.701000													106	29					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18523812	18523812	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:18523812G>A	ENST00000336714.3	+	14	2093	c.1661G>A	c.(1660-1662)cGa>cAa	p.R554Q	SEC23B_ENST00000377465.1_Missense_Mutation_p.R554Q|SEC23B_ENST00000377475.3_Missense_Mutation_p.R554Q|SEC23B_ENST00000262544.2_Missense_Mutation_p.R554Q	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	554					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						CAACTCATCCGACTGGTAAAT	0.507000													97	80					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238285684	238285684	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:238285684C>T	ENST00000295550.4	-	7	3253	c.2801G>A	c.(2800-2802)aGc>aAc	p.S934N	COL6A3_ENST00000392004.3_Missense_Mutation_p.S728N|COL6A3_ENST00000392003.2_Missense_Mutation_p.S527N|COL6A3_ENST00000347401.3_Missense_Mutation_p.S733N|COL6A3_ENST00000409809.1_Missense_Mutation_p.S728N|COL6A3_ENST00000472056.1_Missense_Mutation_p.S327N|COL6A3_ENST00000346358.4_Missense_Mutation_p.S734N|COL6A3_ENST00000353578.4_Missense_Mutation_p.S728N	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	934	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTCGATCCGGCTGCCAGCAGA	0.542000													24	56					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616692	77616692	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:77616692C>T	ENST00000521891.2	+	2	817	c.369C>T	c.(367-369)gaC>gaT	p.D123D	ZFHX4_ENST00000050961.6_Silent_p.D123D|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.D123D|ZFHX4_ENST00000455469.2_Silent_p.D123D	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	123						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGACAGTGACGTGGAAAATC	0.493000										HNSCC(33;0.089)			65	47					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50600867	50600867	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:50600867G>A	ENST00000216373.5	-	19	3323	c.3049C>T	c.(3049-3051)Cga>Tga	p.R1017*	SOS2_ENST00000543680.1_Nonsense_Mutation_p.R984*	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	1017	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTGCAGTTTCGAGGTTCAATT	0.323000													4	150					0	0	1	0	0
USP44	84101	broad.mit.edu	37	12	95927582	95927582	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:95927582A>G	ENST00000258499.3	-	2	739	c.451T>C	c.(451-453)Tgg>Cgg	p.W151R	USP44_ENST00000552440.1_Missense_Mutation_p.W151R|USP44_ENST00000537435.2_Missense_Mutation_p.W151R|USP44_ENST00000393091.2_Missense_Mutation_p.W151R	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	151					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						CTCCTGTGCCAAAGAGCAGTA	0.393000													20	50					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7750719	7750719	+	Silent	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:7750719T>C	ENST00000254846.5	+	10	1595	c.1206T>C	c.(1204-1206)agT>agC	p.S402S	KDM6B_ENST00000448097.2_Silent_p.S402S	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	402	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						gcagcagcagtagcagcagca	0.657000													24	84					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76755393	76755393	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr18:76755393G>A	ENST00000536229.3	+	2	3496	c.2787G>A	c.(2785-2787)acG>acA	p.T929T	SALL3_ENST00000537592.2_Silent_p.T1134T|SALL3_ENST00000575389.2_Silent_p.T1062T			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ATGAGCGCACGCACACCGGCG	0.682000													7	4					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94929634	94929634	+	Splice_Site	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:94929634C>A	ENST00000337425.5	-	5	1179		c.e5-1		SERPINA9_ENST00000298845.7_Splice_Site|SERPINA9_ENST00000424550.2_Splice_Site|SERPINA9_ENST00000448305.2_Splice_Site|RP11-349I1.2_ENST00000536735.1_RNA|SERPINA9_ENST00000380365.3_Splice_Site	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9						regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TGTGGGTTGCCTGCCAAGGGA	0.502000													32	26					1.08312e-15	1.23053e-15	1	1	0
FYTTD1	84248	broad.mit.edu	37	3	197497115	197497115	+	Splice_Site	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:197497115A>G	ENST00000428395.2	+	5	657	c.224_splice	c.e5+1	p.K75_splice	FYTTD1_ENST00000415708.2_Splice_Site_p.K140_splice|FYTTD1_ENST00000241502.3_Splice_Site_p.K166_splice|FYTTD1_ENST00000424384.2_Splice_Site_p.K99_splice	NM_001011537.2	NP_001011537.2	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1	166					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		CTAAGCAGAAAGTAAGTGCTC	0.363000													13	39					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50054268	50054268	+	Silent	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:50054268A>G	ENST00000376042.1	+	6	3397	c.3099A>G	c.(3097-3099)ttA>ttG	p.L1033L	CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Silent_p.L1033L|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	1033					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CATTGGCCTTACAAGAGAGTC	0.478000													37	15					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176562	57176562	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:57176562T>C	ENST00000537055.2	-	2	236	c.5A>G	c.(4-6)gAg>gGg	p.E2G		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CAAGAGTCCCTCCATCCTCGA	0.498000													12	45					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86468447	86468447	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:86468447C>T	ENST00000361669.2	+	4	2716	c.1617C>T	c.(1615-1617)taC>taT	p.Y539Y	GRM3_ENST00000394720.2_Intron|GRM3_ENST00000546348.1_Silent_p.Y131Y|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000536043.1_Silent_p.Y411Y	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	539					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCTACGAATACCTGGCTGATG	0.532000													77	70					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135385250	135385250	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr5:135385250C>T	ENST00000442011.2	+	7	1055	c.894C>T	c.(892-894)ggC>ggT	p.G298G	TGFBI_ENST00000305126.8_Silent_p.G298G	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	298	FAS1 2.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding	p.G298G(1)		breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTATCCTGGGCGACCCAGAAG	0.542000													3	24					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57287809	57287809	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:57287809C>T	ENST00000543872.2	+	2	661	c.397C>T	c.(397-399)Cag>Tag	p.Q133*	SMG8_ENST00000578922.1_Nonsense_Mutation_p.Q133*|SMG8_ENST00000580498.1_Intron|SMG8_ENST00000300917.5_Nonsense_Mutation_p.Q133*|CTD-2510F5.6_ENST00000577660.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	133					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						GGCAGGCTCCCAGGACTACAG	0.597000													4	38					0	0	1	0	0
CYB5R4	51167	broad.mit.edu	37	6	84665107	84665107	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:84665107G>A	ENST00000369681.4	+	15	1577	c.1437G>A	c.(1435-1437)ttG>ttA	p.L479L		NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	479					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CTGAATTTTTGAAAAGAAATT	0.393000													24	46					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25585277	25585277	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:25585277C>T	ENST00000232165.3	-	12	3109	c.2453G>A	c.(2452-2454)gGa>gAa	p.G818E	UBE3A_ENST00000428984.2_Missense_Mutation_p.G798E|UBE3A_ENST00000438097.1_Missense_Mutation_p.G798E|UBE3A_ENST00000566215.1_Missense_Mutation_p.G798E|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000397954.2_Missense_Mutation_p.G821E	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	821	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CTTTAATTTTCCTAGTCCTCC	0.413000													15	61					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31856267	31856267	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:31856267G>A	ENST00000395728.3	-	11	1552	c.1553C>T	c.(1552-1554)gCc>gTc	p.A518V	EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375528.4_Missense_Mutation_p.A484V|EHMT2_ENST00000375530.4_Missense_Mutation_p.A427V|EHMT2_ENST00000375537.4_Missense_Mutation_p.A461V			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	461					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GAGGATGGCGGCATTGCAGCC	0.662000													3	35					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56949990	56949990	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:56949990G>A	ENST00000497933.1	+	1	770	c.623G>A	c.(622-624)cGa>cAa	p.R208Q		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	178						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						ATGCAGCTCCGAGACCTGGAC	0.647000													27	99					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183094593	183094593	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:183094593G>A	ENST00000258341.4	+	15	2966	c.2709G>A	c.(2707-2709)ggG>ggA	p.G903G	LAMC1_ENST00000466964.1_3'UTR	NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	903	Laminin EGF-like 9.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGTGACGGGGCAGTGTGAAT	0.527000													61	46					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71491651	71491651	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr9:71491651G>A	ENST00000265382.3	+	6	564	c.259G>A	c.(259-261)Gct>Act	p.A87T	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.A87T	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	87	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TAAGACATACGCTCCATTAGC	0.378000													26	55					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21789467	21789467	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:21789467A>G	ENST00000206660.6	+	12	1517	c.1517A>G	c.(1516-1518)aAt>aGt	p.N506S	RPGRIP1_ENST00000557771.1_Missense_Mutation_p.N479S|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.N479S|RPGRIP1_ENST00000553500.1_Intron|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.N506S|RPGRIP1_ENST00000382933.4_Missense_Mutation_p.N148S			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	506					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAGGTGCTAAATGAGTTGCAA	0.428000													17	23					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431139	67431139	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:67431139C>T	ENST00000349015.3	-	9	1405	c.967G>A	c.(967-969)Gga>Aga	p.G323R	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.G323R	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	323					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CCACCGACTCCCCCGAATGGC	0.582000													7	42					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63477029	63477029	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr18:63477029C>A	ENST00000536984.2	+	3	994	c.300C>A	c.(298-300)aaC>aaA	p.N100K	CDH7_ENST00000323011.3_Missense_Mutation_p.N100K|CDH7_ENST00000397968.2_Missense_Mutation_p.N100K			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	100	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TTGATGAGAACACTGGGGATA	0.483000													24	31					3.01185e-09	3.24874e-09	1	1	0
ERBB2	2064	broad.mit.edu	37	17	37882904	37882904	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:37882904G>A	ENST00000406381.2	+	26	3382	c.2872G>A	c.(2872-2874)Gtc>Atc	p.V958I	ERBB2_ENST00000269571.5_Missense_Mutation_p.V988I|ERBB2_ENST00000584601.1_Missense_Mutation_p.V958I|ERBB2_ENST00000541774.1_Missense_Mutation_p.V973I|ERBB2_ENST00000540147.1_Missense_Mutation_p.V958I|ERBB2_ENST00000584450.1_Missense_Mutation_p.V988I|ERBB2_ENST00000445658.2_Missense_Mutation_p.V712I	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	988	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GCGCTTTGTGGTCATCCAGGT	0.602000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			7	56					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71946906	71946906	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:71946906C>T	ENST00000541756.1	+	25	2959	c.2029C>T	c.(2029-2031)Cca>Tca	p.P677S	INPPL1_ENST00000298229.2_Missense_Mutation_p.P919S|INPPL1_ENST00000538751.1_Missense_Mutation_p.P677S			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	919					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GAGCCGCAAGCCAGCCTTCAC	0.612000													4	81					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62598610	62598610	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:62598610G>C	ENST00000512091.1	+	7	1280	c.533G>C	c.(532-534)aGa>aCa	p.R178T	LPHN3_ENST00000514591.1_Missense_Mutation_p.R178T|LPHN3_ENST00000507164.1_Missense_Mutation_p.R246T|LPHN3_ENST00000514157.1_Missense_Mutation_p.R178T|LPHN3_ENST00000511324.1_Missense_Mutation_p.R246T|LPHN3_ENST00000506746.1_Missense_Mutation_p.R246T|LPHN3_ENST00000545650.1_Missense_Mutation_p.R178T|LPHN3_ENST00000506720.1_Missense_Mutation_p.R246T|LPHN3_ENST00000504896.1_Missense_Mutation_p.R178T|LPHN3_ENST00000507625.1_Missense_Mutation_p.R246T|LPHN3_ENST00000509896.1_Missense_Mutation_p.R246T|LPHN3_ENST00000514996.1_Missense_Mutation_p.R178T|LPHN3_ENST00000506700.1_Missense_Mutation_p.R178T|LPHN3_ENST00000508693.1_Missense_Mutation_p.R246T|LPHN3_ENST00000508946.1_Missense_Mutation_p.R178T			Q9HAR2	LPHN3_HUMAN	latrophilin 3	178	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ACTCCCTACAGAACTGATACC	0.483000													15	43					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39219731	39219731	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:39219731G>T	ENST00000252699.2	+	20	2590	c.2514G>T	c.(2512-2514)gaG>gaT	p.E838D	ACTN4_ENST00000497637.1_3'UTR|ACTN4_ENST00000424234.2_Missense_Mutation_p.E448D|ACTN4_ENST00000390009.3_Missense_Mutation_p.E619D	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	838	EF-hand 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTCGCGGGAGACCACCGACA	0.612000													14	159					4.7546e-09	5.07158e-09	1	1	0
XKR4	114786	broad.mit.edu	37	8	56015384	56015384	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:56015384C>A	ENST00000327381.5	+	1	436	c.336C>A	c.(334-336)tgC>tgA	p.C112*		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	112						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGTGGGACTGCCTCTGGATCC	0.751000													24	35					3.6726e-16	4.22239e-16	1	1	0
GPR17	2840	broad.mit.edu	37	2	128408482	128408482	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:128408482G>A	ENST00000544369.1	+	4	868	c.257G>A	c.(256-258)cGa>cAa	p.R86Q	LIMS2_ENST00000409808.2_Intron|GPR17_ENST00000393018.3_Missense_Mutation_p.R86Q|LIMS2_ENST00000410011.1_Intron|LIMS2_ENST00000324938.5_Intron|GPR17_ENST00000272644.3_Missense_Mutation_p.R86Q|LIMS2_ENST00000355119.4_Intron|GPR17_ENST00000486700.1_3'UTR|LIMS2_ENST00000545738.2_Intron|LIMS2_ENST00000409455.1_Intron	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	86						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		CTTTTCATCCGAGACCACAAG	0.587000													83	84					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120118212	120118212	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:120118212C>T	ENST00000332843.2	+	6	657	c.616C>T	c.(616-618)Cgg>Tgg	p.R206W		NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	206	C-type lectin.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			TGGCTTCTTTCGGGTGTTCAT	0.517000													52	54					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126086270	126086270	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:126086270C>A	ENST00000339582.2	-	10	3395	c.2587G>T	c.(2587-2589)Gcc>Tcc	p.A863S	GRM8_ENST00000444921.2_Missense_Mutation_p.A863S|GRM8_ENST00000358373.3_Missense_Mutation_p.A863S			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	863					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGCATGGTGGCAGCTGTCACC	0.423000										HNSCC(24;0.065)			35	110					1.836e-18	2.13644e-18	1	1	0
PAXIP1	22976	broad.mit.edu	37	7	154746133	154746133	+	Splice_Site	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:154746133T>C	ENST00000404141.1	-	16	2807	c.2652_splice	c.e16-1	p.K885_splice	PAXIP1_ENST00000473219.1_5'UTR|PAXIP1_ENST00000397192.1_Splice_Site_p.K885_splice			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	885	BRCT 5.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		ATGTAGAGCTTCTAAAGGTCA	0.483000													7	25					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29519891	29519891	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:29519891C>G	ENST00000389048.3	-	9	2586	c.1680G>C	c.(1678-1680)ttG>ttC	p.L560F	ALK_ENST00000498037.1_5'UTR|ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	560	MAM 2.		L -> F (in a breast pleomorphic lobular carcinoma sample; somatic mutation).		protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.L560L(1)|p.L560F(1)	ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CGTTTCCCCTCAAGACTCCAC	0.547000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				34	45					0	0	1	0	0
GSTM4	2948	broad.mit.edu	37	1	110199046	110199046	+	Splice_Site	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:110199046G>A	ENST00000369836.4	+	1	344	c.36_splice	c.e1+1	p.G12_splice	GSTM4_ENST00000336075.5_Splice_Site_p.G12_splice|GSTM4_ENST00000369833.1_5'UTR|GSTM4_ENST00000495742.1_3'UTR|GSTM4_ENST00000326729.5_Splice_Site_p.G12_splice	NM_000850.4	NP_000841.1	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4	12	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GACATCCGCGGGGTGAGTGAG	0.652000													27	106					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155529728	155529728	+	Silent	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:155529728A>G	ENST00000404648.3	-	7	980	c.741T>C	c.(739-741)acT>acC	p.T247T	FGG_ENST00000336098.3_Silent_p.T247T|FGG_ENST00000407946.1_Silent_p.T255T|FGG_ENST00000405164.1_Silent_p.T255T	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	247	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CTGTTGTGCCAGTAGGAGACA	0.388000													13	60					0	0	1	0	0
CRBN	51185	broad.mit.edu	37	3	3215894	3215894	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:3215894C>T	ENST00000231948.4	-	3	248	c.226G>A	c.(226-228)Gac>Aac	p.D76N	CRBN_ENST00000432408.2_Missense_Mutation_p.D75N	NM_016302.3	NP_057386.2	Q96SW2	CRBN_HUMAN	cereblon	76					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	11				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		TGACAGCTGTCGTCATCGTGC	0.398000													14	38					0	0	1	0	0
CCNL2	81669	broad.mit.edu	37	1	1325745	1325745	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:1325745G>C	ENST00000400809.3	-	8	876	c.871C>G	c.(871-873)Ctc>Gtc	p.L291V	CCNL2_ENST00000505849.1_5'UTR|CCNL2_ENST00000408952.5_Missense_Mutation_p.L69V	NM_030937.4	NP_112199.2	Q96S94	CCNL2_HUMAN	cyclin L2	291					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		AGGTGTGTGAGATCAACCTGC	0.517000													28	55					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25230329	25230329	+	RNA	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:25230329C>T	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						TACTGTCAGTCTAAGGACTCA	0.393000													10	31					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	6					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	69954473	69954473	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr11:69954473G>A	ENST00000355303.5	+	6	1067	c.762G>A	c.(760-762)ttG>ttA	p.L254L	ANO1_ENST00000398543.2_Silent_p.L138L|ANO1_ENST00000538023.1_Silent_p.L254L|ANO1_ENST00000531349.1_5'UTR|ANO1_ENST00000530676.1_Silent_p.L138L|ANO1_ENST00000316296.5_Silent_p.L226L	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	254					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						ATGAGATCTTGAAGAGAACGA	0.502000													23	252					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23191872	23191872	+	RNA	SNP	T	T	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr15:23191872T>A	ENST00000400153.2	-	0	1824					NR_003521.1																						TATCTTATGCTTTCTTCAGCC	0.418000													15	65					0	0	1	0	0
RGS18	64407	broad.mit.edu	37	1	192153626	192153626	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:192153626G>T	ENST00000367460.3	+	5	831	c.650G>T	c.(649-651)cGc>cTc	p.R217L		NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	217					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGACGATCACGCTCATTTACC	0.348000													20	46					3.51602e-12	3.85757e-12	1	1	0
ZNF491	126069	broad.mit.edu	37	19	11917357	11917357	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:11917357A>C	ENST00000323169.5	+	3	920	c.589A>C	c.(589-591)Aat>Cat	p.N197H	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						GAAATCATTCAATTTTTCCAG	0.433000													14	26					0	0	1	0	0
EPN1	29924	broad.mit.edu	37	19	56190148	56190148	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr19:56190148C>T	ENST00000411543.2	+	3	1035	c.488C>T	c.(487-489)gCc>gTc	p.A163V	EPN1_ENST00000270460.6_Missense_Mutation_p.A52V|EPN1_ENST00000085079.7_Missense_Mutation_p.A52V	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	52					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		AACGTTGTCGCCTTCTCGGAG	0.582000													18	40					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378104	19378104	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:19378104T>C	ENST00000550708.1	+	1	583	c.511T>C	c.(511-513)Ttc>Ctc	p.F171L		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTCTGTGGTTCCTGATCCC	0.488000													24	329					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42226060	42226060	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:42226060C>T	ENST00000319977.4	+	3	1126	c.889C>T	c.(889-891)Cct>Tct	p.P297S	C17orf53_ENST00000585683.1_Missense_Mutation_p.P297S|C17orf53_ENST00000245382.6_Missense_Mutation_p.P297S	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	297										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AAATCGTTTCCCTTGTCAGCC	0.527000													126	124					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30872091	30872091	+	Silent	SNP	A	A	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:30872091A>C	ENST00000251071.5	-	13	2967	c.2217T>G	c.(2215-2217)tcT>tcG	p.S739S	CAPRIN2_ENST00000417045.1_Silent_p.S739S|CAPRIN2_ENST00000308433.5_Silent_p.S406S|CAPRIN2_ENST00000395805.2_Silent_p.S704S|CAPRIN2_ENST00000298892.5_Intron	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	739					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AGCCCTGTTCAGAGCCCTTTG	0.498000													56	441					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70541926	70541926	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:70541926G>T	ENST00000310961.5	+	24	4575	c.4157G>T	c.(4156-4158)gGa>gTa	p.G1386V	LRRC7_ENST00000415775.2_Missense_Mutation_p.G712V|LRRC7_ENST00000035383.5_Missense_Mutation_p.G1428V			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1428						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCTCAGCCTGGACGGTGCTTA	0.438000													20	82					2.37509e-13	2.62079e-13	1	1	0
FAM86JP	100125556	broad.mit.edu	37	3	125643926	125643926	+	RNA	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:125643926C>A	ENST00000485843.1	+	0	450					NR_024251.1																						GTCCGCAACCCAGAGACATGC	0.657000													31	73					2.08457e-15	2.35434e-15	1	1	0
RNF113B	140432	broad.mit.edu	37	13	98829181	98829181	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr13:98829181C>T	ENST00000267291.6	-	1	338	c.310G>A	c.(310-312)Ggg>Agg	p.G104R	FARP1_ENST00000376581.5_Intron|FARP1_ENST00000595437.1_Intron|FARP1_ENST00000376586.2_Intron|FARP1_ENST00000319562.6_Intron	NM_178861.4	NP_849192.1	Q8IZP6	R113B_HUMAN	ring finger protein 113B	104							nucleic acid binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TCCTCTGGCCCCACAGGCTTC	0.687000													24	37					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113826348	113826348	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:113826348A>T	ENST00000280800.3	+	12	1718	c.1687A>T	c.(1687-1689)Agc>Tgc	p.S563C	PLBD2_ENST00000545182.2_Missense_Mutation_p.S531C	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	563					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GTTCCAGTGGAGCACCTCGCC	0.647000													5	14					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20278851	20278851	+	Silent	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr20:20278851G>A	ENST00000245957.5	+	25	3319	c.3243G>A	c.(3241-3243)gcG>gcA	p.A1081A	C20orf26_ENST00000377309.2_3'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	1081										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CCGGCAGTGCGAAAAATGGGA	0.428000													25	65					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101717845	101717845	+	Silent	SNP	G	G	A	rs138307186		TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:101717845G>A	ENST00000318607.5	-	12	2787	c.1659C>T	c.(1657-1659)gcC>gcT	p.A553A	PABPC1_ENST00000519004.1_Silent_p.A508A|PABPC1_ENST00000522387.1_Silent_p.A521A	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	553	PABC.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CTTGAGGAGGGGCAGATGCCA	0.428000													6	48					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3761502	3761502	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:3761502C>T	ENST00000378230.3	-	6	859	c.535G>A	c.(535-537)Gag>Aag	p.E179K	CEP104_ENST00000378223.3_Missense_Mutation_p.E179K	NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	179						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GCAGGGTCCTCGCTGTTGTGC	0.478000													9	44					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94155053	94155053	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:94155053T>C	ENST00000553484.1	+	46	7289	c.7135T>C	c.(7135-7137)Ttt>Ctt	p.F2379L	UNC79_ENST00000555664.1_Missense_Mutation_p.F2318L|UNC79_ENST00000256339.4_Missense_Mutation_p.F2180L|UNC79_ENST00000393151.2_Missense_Mutation_p.F2357L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2357						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGAAGATACCTTTGGGGGACA	0.507000													20	58					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215963407	215963407	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:215963407C>T	ENST00000366943.2	-	51	10562	c.10176G>A	c.(10174-10176)atG>atA	p.M3392I	USH2A_ENST00000307340.3_Missense_Mutation_p.M3392I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3392					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.M3392I(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTACCTTCATCATCATTCCAG	0.333000										HNSCC(13;0.011)			9	37					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50147090	50147090	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:50147090A>G	ENST00000347869.3	+	15	1422	c.1247A>G	c.(1246-1248)tAt>tGt	p.Y416C	RBM5_ENST00000441812.2_3'UTR	NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	416	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCTCAGCTGTATAATCAAACC	0.473000													54	102					0	0	1	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184629643	184629643	+	Silent	SNP	A	A	G	rs113269326	byFrequency	TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:184629643A>G	ENST00000334690.6	+	29	3475	c.3273A>G	c.(3271-3273)ccA>ccG	p.P1091P	TRAPPC11_ENST00000357207.4_Intron|TRAPPC11_ENST00000512476.1_Silent_p.P697P	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	1091																	AGCAGCTGCCATCTCTCAACA	0.413000													22	35					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79708024	79708024	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:79708024T>C	ENST00000275034.4	-	18	2131	c.1964A>G	c.(1963-1965)gAc>gGc	p.D655G		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	655					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ACGTCTCAGGTCTTGCTCCTG	0.388000													14	31					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99808698	99808698	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:99808698C>T	ENST00000426455.1	+	30	3710	c.3303C>T	c.(3301-3303)agC>agT	p.S1101S	GATS_ENST00000436886.2_Intron|STAG3_ENST00000394018.2_Silent_p.S1043S|STAG3_ENST00000440830.1_3'UTR|GATS_ENST00000543273.1_RNA|STAG3_ENST00000317296.5_Silent_p.S1101S			Q9UJ98	STAG3_HUMAN	stromal antigen 3	1101					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCTGAACAGCATCCCGCCCA	0.577000													33	77					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65145895	65145895	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr4:65145895C>T	ENST00000381210.3	-	12	1097	c.987G>A	c.(985-987)atG>atA	p.M329I	TECRL_ENST00000507440.1_Intron	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	329					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TCTGGATACTCATCAGAAGTG	0.274000													6	25					0	0	1	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454293	114454293	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:114454293G>T	ENST00000369563.3	+	4	1525	c.1079G>T	c.(1078-1080)aGt>aTt	p.S360I	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	360					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTGAGGAAAGTGCTGATCAA	0.488000								Other identified genes with known or suspected DNA repair function					34	81					9.04072e-19	1.05843e-18	1	1	0
PAXBP1	94104	broad.mit.edu	37	21	34127589	34127589	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr21:34127589G>A	ENST00000331923.4	-	8	1648	c.1459C>T	c.(1459-1461)Cga>Tga	p.R487*	PAXBP1_ENST00000290178.4_Nonsense_Mutation_p.R487*	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TCATCTTGTCGTCTTTGGACA	0.373000											OREG0003541	type=REGULATORY REGION|Gene=C21orf66|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	35					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179526210	179526210	+	Silent	SNP	C	C	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:179526210C>A	ENST00000467460.1	-	13	1698	c.1368G>T	c.(1366-1368)ggG>ggT	p.G456G	PEX5L_ENST00000465751.1_Silent_p.G432G|PEX5L_ENST00000464614.1_Silent_p.G348G|PEX5L_ENST00000392649.3_Silent_p.G348G|PEX5L_ENST00000263962.8_Silent_p.G454G|PEX5L_ENST00000485199.1_Silent_p.G421G|PEX5L_ENST00000476138.1_Silent_p.G413G|PEX5L_ENST00000472994.1_Silent_p.G397G|PEX5L_ENST00000468741.1_Silent_p.G264G|PEX5L_ENST00000467440.2_5'UTR	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	456					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ATTCCTTCACCCCTTCCAGAA	0.398000													17	110					0.006122	0.00621918	1	1	0
CDC42BPB	9578	broad.mit.edu	37	14	103438345	103438345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:103438345G>A	ENST00000361246.2	-	13	2083	c.1795C>T	c.(1795-1797)Cga>Tga	p.R599*		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	599					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TCCTTGTCTCGCAGCTGCCGG	0.617000													4	143					0	0	1	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775416	27775416	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:27775416A>G	ENST00000377401.2	-	1	293	c.269T>C	c.(268-270)aTc>aCc	p.I90T		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	90					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CCTGGAGGTGATGGTCGAGCG	0.627000													48	130					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67109491	67109491	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:67109491A>G	ENST00000284425.2	-	15	2087	c.1913T>C	c.(1912-1914)tTa>tCa	p.L638S		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	638	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TGGTTCATCTAAAAGCAAAAT	0.368000													15	15					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23415099	23415099	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:23415099C>T	ENST00000307149.5	-	13	1904	c.1719G>A	c.(1717-1719)cgG>cgA	p.R573R		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	573					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GCTGGTTAAGCCGAGTCAGCG	0.512000													28	35					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120622	193120622	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr3:193120622A>C	ENST00000342695.4	-	30	3732	c.3410T>G	c.(3409-3411)aTg>aGg	p.M1137R	ATP13A4_ENST00000482964.1_5'UTR|ATP13A4_ENST00000392443.3_Missense_Mutation_p.M1118R|ATP13A4_ENST00000400270.2_Missense_Mutation_p.M153R	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1137					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTTAATCATCATCCACAGGGC	0.448000													10	65					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88858450	88858450	+	Silent	SNP	C	C	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:88858450C>T	ENST00000303236.3	-	16	3436	c.3135G>A	c.(3133-3135)caG>caA	p.Q1045Q	AC104134.2_ENST00000413234.1_RNA|EIF2AK3_ENST00000419748.1_Silent_p.Q894Q	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	1045	Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						AAGGATATTTCTGAGTAAATA	0.313000													15	16					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173748	126173748	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:126173748T>A	ENST00000339582.2	-	9	2496	c.1688A>T	c.(1687-1689)aAc>aTc	p.N563I	GRM8_ENST00000444921.2_Missense_Mutation_p.N563I|GRM8_ENST00000358373.3_Missense_Mutation_p.N563I|GRM8_ENST00000480995.1_5'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	563					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCGGTTCATGTTGGGTCTCTG	0.522000										HNSCC(24;0.065)			32	70					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96792231	96792231	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:96792231T>C	ENST00000359933.4	-	15	3085	c.2192A>G	c.(2191-2193)gAt>gGt	p.D731G		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	731										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATGTGAATCATCTAGAAACAC	0.348000													38	34					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112257	59112257	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr14:59112257T>C	ENST00000395153.3	+	4	952	c.805T>C	c.(805-807)Tgc>Cgc	p.C269R	DACT1_ENST00000556859.1_Missense_Mutation_p.C25R|DACT1_ENST00000395151.3_Missense_Mutation_p.C25R|DACT1_ENST00000541264.2_Missense_Mutation_p.C25R|DACT1_ENST00000335867.4_Missense_Mutation_p.C306R	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	306					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						CAGTGACATTTGCGGTGGATC	0.522000													45	31					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803276	142803278	+	RNA	DEL	AAC	AAC	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr1:142803276_142803278delAAC	ENST00000423385.1	-	0	1687_1689																											ACCAAACCAAaacaacaacaaca	0.345													3	3	---	---	---	---					
LY75-CD302	100526664	broad.mit.edu	37	2	160637475	160637477	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr2:160637475_160637477delTTC	ENST00000504764.1	-	36	5161_5163	c.5134_5136delGAA	c.(5134-5136)del	p.E1712del	CD302_ENST00000259053.4_In_Frame_Del_p.E71del|LY75-CD302_ENST00000505052.1_In_Frame_Del_p.E1656del|LY75_ENST00000554112.1_In_Frame_Del_p.E1712del|CD302_ENST00000429078.2_In_Frame_Del_p.E71del|LY75_ENST00000553424.1_In_Frame_Del_p.E1656del|CD302_ENST00000480212.1_5'UTR	NM_001198759.1	NP_001185688.1	O60449	LY75_HUMAN		1580					endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding	p.E71Q(1)									TAAAAGCATTTTCTTCTTCATTA	0.335													43	26	---	---	---	---					
TIAM2	26230	broad.mit.edu	37	6	155572056	155572057	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr6:155572056_155572057insT	ENST00000461783.3	+	24	5234_5235	c.3961_3962insT	c.(3961-3963)ttcfs	p.F1321fs	TIAM2_ENST00000528391.2_Frame_Shift_Ins_p.F657fs|TIAM2_ENST00000456144.1_Frame_Shift_Ins_p.F1350fs|TIAM2_ENST00000318981.5_Frame_Shift_Ins_p.F1321fs|TIAM2_ENST00000367174.2_Frame_Shift_Ins_p.F697fs|TIAM2_ENST00000456877.2_Frame_Shift_Ins_p.F633fs|TIAM2_ENST00000275246.7_Frame_Shift_Ins_p.F246fs|TIAM2_ENST00000529824.2_Frame_Shift_Ins_p.F1350fs|TIAM2_ENST00000360366.4_Frame_Shift_Ins_p.F1345fs			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1321					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GGTAACAGAACTTTCGATGGGA	0.421													45	66	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75145720	75145721	+	RNA	DEL	AT	AT	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr7:75145720_75145721delAT	ENST00000418756.1	-	0	618					NR_028059.1															lung(1)	1						TCCTTTGGGGatatatatatat	0.302													2	4	---	---	---	---					
KCNQ3	3786	broad.mit.edu	37	8	133150233	133150233	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr8:133150233delT	ENST00000388996.4	-	12	2019	c.1599delA	c.(1597-1599)aafs	p.K533fs	KCNQ3_ENST00000521134.1_Frame_Shift_Del_p.K413fs|KCNQ3_ENST00000519445.1_Frame_Shift_Del_p.K533fs	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	533					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCTCCTTGAATTTTTTTTTAT	0.453													7	185	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													4	7	---	---	---	---					
TFCP2	7024	broad.mit.edu	37	12	51566196	51566196	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:51566196delC	ENST00000307660.4	-	1	730	c.10delG	c.(10-12)ctfs	p.A4fs	TFCP2_ENST00000549867.1_Frame_Shift_Del_p.A4fs|TFCP2_ENST00000548115.1_Frame_Shift_Del_p.A4fs|TFCP2_ENST00000257915.5_Frame_Shift_Del_p.A4fs	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	4					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						AGCTTCAGAGCCCAGGCCATC	0.577													30	61	---	---	---	---					
LDHAL6CP	121498	broad.mit.edu	37	12	63398006	63398007	+	RNA	DEL	AA	AA	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr12:63398006_63398007delAA	ENST00000550738.1	+	0	548_549																											TTCATTGGACAAAAGCTTGGTA	0.460													25	39	---	---	---	---					
EIF3C	8663	broad.mit.edu	37	16	28734579	28734581	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr16:28734579_28734581delGAG	ENST00000331666.6	+	9	1057_1059	c.871_873delGAG	c.(871-873)del	p.E294del	EIF3C_ENST00000566866.1_In_Frame_Del_p.E294del|EIF3C_ENST00000564243.1_In_Frame_Del_p.E284del|EIF3C_ENST00000395587.1_In_Frame_Del_p.E294del|EIF3C_ENST00000566501.1_In_Frame_Del_p.E294del			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	294	Poly-Glu.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						GCGCCTGGATGAGGAGGAGGAGG	0.562													7	1205	---	---	---	---					
RAPGEFL1	51195	broad.mit.edu	37	17	38340867	38340867	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr17:38340867delT	ENST00000436615.3	+	4	642	c.152delT	c.(151-153)ctfs	p.L51fs	RAPGEFL1_ENST00000264644.6_Frame_Shift_Del_p.L51fs|RAPGEFL1_ENST00000544503.1_Frame_Shift_Del_p.L100fs|RAPGEFL1_ENST00000540388.1_3'UTR|RAPGEFL1_ENST00000456989.2_Frame_Shift_Del_p.L106fs	NM_016339.3	NP_057423.1	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor (GEF)-like 1	257	Gly-rich.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						GACGAGTCCCTTTACCAGGGC	0.567													2	4	---	---	---	---					
IGLV1-50	28821	broad.mit.edu	37	22	22681921	22681921	+	RNA	DEL	C	C	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chr22:22681921delC	ENST00000390291.2	+	0	154																											GGCCCCAGGGCAGAGGGTCAC	0.597													65	110	---	---	---	---					
P2RY8	286530	broad.mit.edu	37	X	1585382	1585382	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IQ-A61G-01A-11D-A30E-08	TCGA-IQ-A61G-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04522aa6-0bb7-47fd-af3f-b3e2d8937f76	0584501b-8e3d-422f-94d7-d2529d73640a	g.chrX:1585382delC	ENST00000381297.4	-	2	280	c.70delG	c.(70-72)tgfs	p.V24fs	P2RY8_ENST00000460672.1_5'UTR	NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	24						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCAGGGCCACCGCGATCGCC	0.706			T	CRLF2	"""B-ALL, Downs associated ALL"""								25	26	---	---	---	---					
