Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADHFE1	137872	broad.mit.edu	37	8	67357628	67357628	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:67357628C>T	ENST00000396623.3	+	6	560	c.529C>T	c.(529-531)Cct>Tct	p.P177S	ADHFE1_ENST00000415254.1_Missense_Mutation_p.P129S|ADHFE1_ENST00000496501.1_3'UTR|ADHFE1_ENST00000379385.4_Missense_Mutation_p.P177S	NM_144650.2	NP_653251.2	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	177					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	29		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TGTGTCTGTGCCTCTTAAGCC	0.423000													51	120					0	0	1	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654863	161654863	+	RNA	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:161654863G>A	ENST00000426558.1	-	0	179					NR_002595.1																						GAAGCTCTTTGAGTGCCCGAG	0.507000													17	25					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32560674	32560674	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:32560674C>G	ENST00000345122.3	+	2	1114	c.799C>G	c.(799-801)Caa>Gaa	p.Q267E	ARHGAP5_ENST00000556611.1_Missense_Mutation_p.Q267E|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.Q267E|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.Q267E|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	267					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AACACAGAGACAACTTGTTGT	0.328000													25	197					0	0	1	0	0
GPX6	257202	broad.mit.edu	37	6	28474185	28474185	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:28474185T>A	ENST00000361902.1	-	3	312	c.263A>T	c.(262-264)gAg>gTg	p.E88V	GPX6_ENST00000474923.1_Missense_Mutation_p.E88V|GPX6_ENST00000483058.1_5'UTR	NM_182701.1	NP_874360.1	P59796	GPX6_HUMAN	glutathione peroxidase 6 (olfactory)	88					response to oxidative stress	extracellular region	glutathione peroxidase activity			NS(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Glutathione(DB00143)	ATTCTTCAGCTCCTCCTGTAG	0.458000													24	59					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356180	40356180	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:40356180G>A	ENST00000310169.2	+	5	1222	c.1083G>A	c.(1081-1083)ccG>ccA	p.P361P		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	361					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GCCTCAGCCCGCACCACAGTA	0.547000													4	137					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103431072	103431072	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:103431072G>A	ENST00000358392.2	-	38	3240	c.2923C>T	c.(2923-2925)Cct>Tct	p.P975S	COL11A1_ENST00000512756.1_Missense_Mutation_p.P847S|COL11A1_ENST00000353414.4_Missense_Mutation_p.P924S|COL11A1_ENST00000370096.3_Missense_Mutation_p.P963S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	963	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGCCCAGGAGGGCCGGTC	0.393000													43	94					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91029360	91029360	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:91029360G>A	ENST00000268182.5	+	31	4144	c.4020G>A	c.(4018-4020)ctG>ctA	p.L1340L	IQGAP1_ENST00000560738.1_Silent_p.L768L	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1340	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TCGAGTCCCTGATAGGTAGAG	0.483000													11	36					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116356598	116356598	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr9:116356598G>A	ENST00000462403.1	+	1	833	c.399G>A	c.(397-399)caG>caA	p.Q133Q	RGS3_ENST00000394646.3_Intron|RGS3_ENST00000350696.5_Intron|RGS3_ENST00000374134.3_Intron|RGS3_ENST00000343817.5_Intron|RGS3_ENST00000374140.2_Intron|RGS3_ENST00000462143.1_Intron|RGS3_ENST00000342620.5_Intron	NM_144489.2	NP_652760.2	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1020					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GGAACCTGCAGAGGCGACACA	0.622000													21	54					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40850345	40850345	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr18:40850345C>T	ENST00000255224.3	-	4	1607	c.1239G>A	c.(1237-1239)agG>agA	p.R413R	SYT4_ENST00000586678.1_5'UTR|SYT4_ENST00000590752.1_Silent_p.R395R	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	413						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						CAATTTGTCTCCTGGGGTAGT	0.483000													116	183					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	21000493	21000493	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:21000493C>T	ENST00000274695.4	+	11	1112	c.945C>T	c.(943-945)taC>taT	p.Y315Y	CDKAL1_ENST00000378610.1_Silent_p.Y315Y|CDKAL1_ENST00000378624.4_Silent_p.Y245Y	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	315					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CCAGAGTCTACGCTTTTCTGC	0.393000													54	136					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236898965	236898965	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:236898965G>C	ENST00000366578.4	+	8	894	c.728G>C	c.(727-729)aGa>aCa	p.R243T	ACTN2_ENST00000542672.1_Intron|ACTN2_ENST00000546208.1_Intron|ACTN2_ENST00000492634.1_3'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	243	Actin-binding.|CH 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCCGATGAAAGAGCCATCATG	0.532000													19	54					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123022969	123022969	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:123022969C>T	ENST00000333479.7	+	4	511	c.334C>T	c.(334-336)Cat>Tat	p.H112Y	KNTC1_ENST00000450485.2_Missense_Mutation_p.H112Y	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	112					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ACATCTTATTCATGTAACATC	0.308000													5	5					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7635887	7635887	+	Splice_Site	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:7635887G>C	ENST00000340080.4	+	11	2617		c.e11-1		MIOS_ENST00000405785.1_Splice_Site	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)											breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTGTTTTGTAGGTTTTTGTGA	0.353000													45	55					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045696	124045696	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:124045696G>C	ENST00000368994.2	+	5	572	c.321G>C	c.(319-321)aaG>aaC	p.K107N	BTBD16_ENST00000260723.4_Missense_Mutation_p.K106N			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	106										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCTTGGCCAAGCTCTACCTGA	0.587000													5	219					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123794272	123794272	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:123794272C>A	ENST00000420886.2	-	25	3426	c.3427G>T	c.(3427-3429)Gat>Tat	p.D1143Y	SBNO1_ENST00000602398.1_Missense_Mutation_p.D1143Y|SBNO1_ENST00000602750.1_Missense_Mutation_p.D1142Y|SBNO1_ENST00000267176.4_Missense_Mutation_p.D1142Y	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1143							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATTCCCATATCATATCTTCCA	0.393000													52	119					7.05377e-20	7.95152e-20	1	1	0
SLK	9748	broad.mit.edu	37	10	105765747	105765747	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:105765747A>T	ENST00000369755.3	+	11	3103	c.2558A>T	c.(2557-2559)cAg>cTg	p.Q853L	SLK_ENST00000335753.4_Missense_Mutation_p.Q853L	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	853					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGCAAACTACAGCAACAACGA	0.348000													43	90					0	0	1	0	0
NCK1	4690	broad.mit.edu	37	3	136646895	136646895	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:136646895G>A	ENST00000481752.1	+	2	216	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	NCK1_ENST00000288986.2_Missense_Mutation_p.E18K			P16333	NCK1_HUMAN	NCK adaptor protein 1	18	SH3 1.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						GGCCCAACAAGAACAAGAGTT	0.388000													38	54					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55728019	55728019	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:55728019G>T	ENST00000379906.2	+	6	1271	c.1016G>T	c.(1015-1017)tGt>tTt	p.C339F	SLC6A2_ENST00000568943.1_Missense_Mutation_p.C339F|SLC6A2_ENST00000566163.1_Missense_Mutation_p.C294F|SLC6A2_ENST00000567238.1_Missense_Mutation_p.C234F|SLC6A2_ENST00000414754.3_Missense_Mutation_p.C339F|SLC6A2_ENST00000561820.1_Missense_Mutation_p.C339F|SLC6A2_ENST00000219833.8_Missense_Mutation_p.C339F	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	339					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GACAACAACTGTTACAGGTAA	0.443000													38	57					9.88483e-10	1.04465e-09	1	1	0
FLAD1	80308	broad.mit.edu	37	1	154965259	154965259	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:154965259G>A	ENST00000292180.3	+	6	1947	c.1625G>A	c.(1624-1626)cGa>cAa	p.R542Q	FLAD1_ENST00000368432.1_Missense_Mutation_p.R445Q|FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000315144.10_Missense_Mutation_p.R445Q|FLAD1_ENST00000368428.1_Missense_Mutation_p.R83Q|FLAD1_ENST00000405236.2_Intron	NM_025207.4	NP_079483.3	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	542	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGTATGACCGAGGGTAAGGG	0.512000													60	142					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629687	155629687	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:155629687A>G	ENST00000368340.5	-	10	2476	c.2368T>C	c.(2368-2370)Ttc>Ctc	p.F790L	MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000295566.4_Missense_Mutation_p.F718L|YY1AP1_ENST00000355499.4_Missense_Mutation_p.F672L|YY1AP1_ENST00000361831.5_Missense_Mutation_p.F661L|YY1AP1_ENST00000407221.1_Missense_Mutation_p.F641L|YY1AP1_ENST00000535662.1_Missense_Mutation_p.F518L|YY1AP1_ENST00000359205.5_Missense_Mutation_p.F661L|YY1AP1_ENST00000368339.5_Missense_Mutation_p.F810L|YY1AP1_ENST00000404643.1_Missense_Mutation_p.F652L|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000347088.5_Missense_Mutation_p.F672L|YY1AP1_ENST00000368330.2_Missense_Mutation_p.F672L|YY1AP1_ENST00000311573.5_Missense_Mutation_p.F641L	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					ACTTTGGGGAAAACAGTAGCA	0.507000													31	105					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197566209	197566209	+	Silent	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:197566209A>G	ENST00000438796.2	+	10	1313	c.1269A>G	c.(1267-1269)ccA>ccG	p.P423P	LRCH3_ENST00000425562.2_Silent_p.P423P|LRCH3_ENST00000414675.2_Silent_p.P395P|LRCH3_ENST00000334859.4_Silent_p.P423P|LRCH3_ENST00000441090.2_Silent_p.P269P|LRCH3_ENST00000536618.1_Silent_p.P18P			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	423						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		CAGTAAAGCCAGTAGCCATTA	0.328000													30	51					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32131522	32131522	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:32131522C>A	ENST00000373672.3	-	54	3933	c.3417G>T	c.(3415-3417)gaG>gaT	p.E1139D	COL16A1_ENST00000271069.6_Missense_Mutation_p.E1139D	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1139	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGGTCCTCGCTCTCCTCTGG	0.612000													21	43					6.21321e-17	6.96179e-17	1	1	0
GIMAP6	474344	broad.mit.edu	37	7	150325463	150325463	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:150325463C>T	ENST00000328902.5	-	3	439	c.223G>A	c.(223-225)Gtg>Atg	p.V75M	GIMAP6_ENST00000493969.1_Intron	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	75							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTCTTGGTCACGGGTCTGGTG	0.577000													112	139					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920399	160920399	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:160920399G>A	ENST00000368029.3	-	5	601	c.544C>T	c.(544-546)Cgc>Tgc	p.R182C	ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	182	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTGTTGGTGCGGTACCTCAGC	0.577000													41	128					0	0	1	0	0
REC8	9985	broad.mit.edu	37	14	24648888	24648888	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:24648888G>A	ENST00000311457.3	+	18	2003	c.1404G>A	c.(1402-1404)gtG>gtA	p.V468V	REC8_ENST00000559919.1_Silent_p.V468V|REC8_ENST00000559939.1_3'UTR			O95072	REC8_HUMAN	REC8 meiotic recombination protein	469	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(265;0.00839)		TGCCTTTGGTGCTGCCCCCAG	0.632000													23	52					0	0	1	0	0
VSIG2	23584	broad.mit.edu	37	11	124619698	124619698	+	Silent	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:124619698C>G	ENST00000403470.1	-	4	547	c.492G>C	c.(490-492)ctG>ctC	p.L164L	VSIG2_ENST00000326621.5_Silent_p.L164L			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	164	Ig-like C2-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		AGCTGCATCTCAGTGCAGTAG	0.473000													43	32					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182643	109182643	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:109182643C>G	ENST00000326495.5	-	15	2364	c.2271G>C	c.(2269-2271)ttG>ttC	p.L757F	SSH1_ENST00000360239.3_Missense_Mutation_p.L445F	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	757					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GAGAATTCTTCAAAAGGAGGG	0.527000													61	116					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	58					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110300656	110300656	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:110300656C>A	ENST00000369805.3	-	9	974	c.745G>T	c.(745-747)Gac>Tac	p.D249Y	EPS8L3_ENST00000361852.4_Missense_Mutation_p.D248Y|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361965.4_Missense_Mutation_p.D248Y	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	248						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		AGCTCAATGTCCCTTAGGACA	0.562000													36	68					2.05212e-20	2.3274e-20	1	1	0
UNC5D	137970	broad.mit.edu	37	8	35402012	35402012	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:35402012C>A	ENST00000453357.2	+	1	103	c.47C>A	c.(46-48)aCt>aAt	p.T16N	UNC5D_ENST00000287272.2_Intron|UNC5D_ENST00000416672.1_Intron|UNC5D_ENST00000404895.2_Intron|UNC5D_ENST00000420357.1_Intron			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	0					apoptosis|axon guidance	integral to membrane	receptor activity	p.T16S(1)		NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGTGCTGGGACTTCCGGGTTC	0.423000													27	40					9.39395e-14	1.01586e-13	1	1	0
SART3	9733	broad.mit.edu	37	12	108942937	108942937	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:108942937G>A	ENST00000228284.3	-	2	600	c.366C>T	c.(364-366)ctC>ctT	p.L122L	SART3_ENST00000431469.2_Silent_p.L122L|SART3_ENST00000552221.1_5'UTR	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	122					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						CTTCCAGCCTGAGCAGTCTGA	0.453000									Porokeratosis				23	51					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34035053	34035053	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:34035053G>A	ENST00000373381.4	-	52	8228	c.8052C>T	c.(8050-8052)tcC>tcT	p.S2684S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2686	Sushi 17.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGTGTATCCGGAATTGCAGG	0.582000													19	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21136517	21136517	+	Silent	SNP	A	A	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:21136517A>C	ENST00000261383.3	-	9	1382	c.1383T>G	c.(1381-1383)gtT>gtG	p.V461V	DNAH3_ENST00000415178.1_Silent_p.V461V|CTC-508F8.1_ENST00000575612.1_RNA	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	461	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGAAAAGGGAAACGAGGTCCT	0.448000													30	67					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7071047	7071047	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:7071047G>A	ENST00000299481.4	+	6	2615	c.2269G>A	c.(2269-2271)Gag>Aag	p.E757K		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	757					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GAAACACCCAGAGTGTAAACT	0.373000													66	49					0	0	1	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115611	220115611	+	Silent	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:220115611G>T	ENST00000392088.2	-	4	1320	c.765C>A	c.(763-765)gcC>gcA	p.A255A	TUBA4A_ENST00000248437.4_Silent_p.A270A|TUBA4A_ENST00000498660.1_5'UTR	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	270					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGCATAGGTGGCCAGGGGGA	0.572000													13	49					7.03913e-09	7.39705e-09	1	1	0
UGT2B15	7366	broad.mit.edu	37	4	69520826	69520826	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:69520826C>G	ENST00000338206.5	-	4	1089	c.1080G>C	c.(1078-1080)caG>caC	p.Q360H		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	360					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GAAGGTCATTCTGGGGTAACC	0.358000													97	213					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49646098	49646098	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:49646098G>A	ENST00000334186.4	+	21	2931	c.2582G>A	c.(2581-2583)tGc>tAc	p.C861Y	PPFIA3_ENST00000602351.1_Missense_Mutation_p.C861Y	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	861	SAM 1.					cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GTGGCCGCCTGCCGGGCCAAT	0.622000													29	65					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79314704	79314704	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:79314704G>A	ENST00000305089.3	-	2	115	c.35C>T	c.(34-36)tCc>tTc	p.S12F		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	12					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						CATCAGGGAGGAGATCAGCAT	0.488000													5	13					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24834300	24834300	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:24834300G>C	ENST00000395799.3	+	24	5608	c.5479G>C	c.(5479-5481)Gaa>Caa	p.E1827Q	TNRC6A_ENST00000432286.2_Missense_Mutation_p.E305Q|TNRC6A_ENST00000315183.7_Missense_Mutation_p.E1778Q	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1827	RRM.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CAGTTCAAAAGAAGAGGTAGT	0.542000													59	80					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29274948	29274948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:29274948C>T	ENST00000379558.4	+	20	3400	c.3049C>T	c.(3049-3051)Cag>Tag	p.Q1017*	FAM179A_ENST00000465300.1_3'UTR|FAM179A_ENST00000403861.2_Nonsense_Mutation_p.Q962*	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	1017							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						ATACCCTTTTCAGCTGGATTA	0.468000													4	18					0	0	1	0	0
RIPK2	8767	broad.mit.edu	37	8	90777641	90777641	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:90777641T>C	ENST00000220751.4	+	3	714	c.400T>C	c.(400-402)Tac>Cac	p.Y134H	RIPK2_ENST00000540020.1_5'UTR	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	134	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGGTGTAAATTACCTGCACAA	0.328000													58	102					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90774046	90774046	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:90774046C>A	ENST00000355740.2	+	9	1067	c.847C>A	c.(847-849)Caa>Aaa	p.Q283K	FAS_ENST00000357339.2_Missense_Mutation_p.Q262K|FAS_ENST00000352159.4_3'UTR|FAS_ENST00000355279.2_3'UTR	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	283	Death.|Interaction with HIPK3 (By similarity).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		TAATTGGCATCAACTTCATGG	0.368000													22	80					2.27731e-05	2.31464e-05	1	1	0
MTERFD1	51001	broad.mit.edu	37	8	97269221	97269221	+	Silent	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:97269221A>G	ENST00000523821.1	-	3	575	c.456T>C	c.(454-456)caT>caC	p.H152H	MTERFD1_ENST00000522822.1_Silent_p.H31H|MTERFD1_ENST00000287025.3_Silent_p.H152H|MTERFD1_ENST00000524341.1_5'UTR			Q96E29	MTER1_HUMAN	MTERF domain containing 1	152					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					GAGTCTCAGAATGATCCACAT	0.378000													33	44					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31238976	31238976	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:31238976G>A	ENST00000383329.3	-	3	507	c.493C>T	c.(493-495)Cag>Tag	p.Q165*	HLA-C_ENST00000376228.5_Nonsense_Mutation_p.Q165*			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	165	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						TGGGTGATCTGAGCCGCGGTG	0.677000													10	38					0	0	1	0	0
WBSCR16	81554	broad.mit.edu	37	7	74470029	74470029	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:74470029T>A	ENST00000503250.2	-	9	1279	c.1210A>T	c.(1210-1212)Agc>Tgc	p.S404C	WBSCR16_ENST00000329959.4_Missense_Mutation_p.S404C			Q96I51	WBS16_HUMAN	Williams-Beuren syndrome chromosome region 16	404										kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						GCAAAGTGGCTGAGTCCACAT	0.557000													4	168					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368272	74368272	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:74368272C>A	ENST00000290438.3	-	8	659	c.619G>T	c.(619-621)Gag>Tag	p.E207*		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	207										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						AGCGCCCGCTCCTTTATGGTC	0.592000													6	257					0.248553	0.248553	1	1	0
GOLGA6B	55889	broad.mit.edu	37	15	72953659	72953659	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:72953659G>T	ENST00000421285.3	+	8	619	c.619G>T	c.(619-621)Gag>Tag	p.E207*		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	207										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						GACCATAAAGGAGCGGGCGCT	0.597000													22	190					8.24728e-16	9.07689e-16	1	1	0
LEKR1	389170	broad.mit.edu	37	3	156763348	156763348	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:156763348G>C	ENST00000470811.1	+	14	2311	c.976G>C	c.(976-978)Gga>Cga	p.G326R	LEKR1_ENST00000356539.4_Missense_Mutation_p.G630R			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	0										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTCTGAAAAAGGAATCCAAAT	0.532000													37	61					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900173	151900173	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chrX:151900173C>T	ENST00000393900.3	-	3	981	c.628G>A	c.(628-630)Gca>Aca	p.A210T	CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Missense_Mutation_p.A210T|MAGEA12_ENST00000393869.3_Missense_Mutation_p.A210T	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	210	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTCTTTTGCGATTATGGCC	0.577000													7	362					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71426711	71426711	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr17:71426711T>C	ENST00000392650.3	-	12	1522	c.1522A>G	c.(1522-1524)Atc>Gtc	p.I508V	SDK2_ENST00000388726.3_Missense_Mutation_p.I508V	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	508	Ig-like C2-type 6.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGCCCTTGATGACACTCTGA	0.617000													19	5					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79264256	79264256	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:79264256C>A	ENST00000419573.3	-	27	3955	c.3681G>T	c.(3679-3681)gaG>gaT	p.E1227D	RASGRF1_ENST00000558480.2_Missense_Mutation_p.E1211D|RASGRF1_ENST00000394745.3_Missense_Mutation_p.E443D	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1229	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ACTGGCGAATCTCTCGGATAA	0.478000													51	173					1.17673e-23	1.36795e-23	1	1	0
TMEM161A	54929	broad.mit.edu	37	19	19243552	19243552	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:19243552C>G	ENST00000450333.2	-	4	237	c.200G>C	c.(199-201)gGc>gCc	p.G67A	TMEM161A_ENST00000592369.1_5'UTR|TMEM161A_ENST00000162044.9_Missense_Mutation_p.G67A|TMEM161A_ENST00000587583.2_Missense_Mutation_p.G67A	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	67					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			CTCACTAAGGCCATTGGCCCA	0.632000													14	24					0	0	1	0	0
ANAPC16	119504	broad.mit.edu	37	10	73983758	73983758	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:73983758C>T	ENST00000299381.4	+	2	204	c.86C>T	c.(85-87)gCc>gTc	p.A29V	ANAPC16_ENST00000470481.2_3'UTR	NM_001242546.1|NM_001242547.1|NM_001242548.1|NM_173473.3	NP_001229475.1|NP_001229476.1|NP_001229477.1|NP_775744.1	Q96DE5	APC16_HUMAN	anaphase promoting complex subunit 16	29					cell division|mitosis|protein ubiquitination	anaphase-promoting complex|cytoplasm				large_intestine(1)|ovary(1)	2						TCAGACCTTGCCCCACCACGG	0.493000													4	117					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688689	55688689	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:55688689A>T	ENST00000358433.2	-	1	327	c.328T>A	c.(328-330)Ttt>Att	p.F110I		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AGGAGGTAAAACTCAGTAACT	0.393000													36	54					0	0	1	0	0
GABARAPL2	11345	broad.mit.edu	37	16	75601963	75601963	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:75601963A>C	ENST00000037243.2	+	3	255	c.119A>C	c.(118-120)cAg>cCg	p.Q40P	GABARAPL2_ENST00000565057.1_Missense_Mutation_p.Q40P|RP11-77K12.8_ENST00000564489.1_RNA|GABARAPL2_ENST00000568455.1_5'UTR|GABARAPL2_ENST00000563744.1_Intron	NM_007285.6	NP_009216.1	P60520	GBRL2_HUMAN	GABA(A) receptor-associated protein-like 2	40	Interaction with GABRG2 (Potential).				autophagy|intra-Golgi vesicle-mediated transport|positive regulation of ATPase activity|protein transport	autophagic vacuole membrane|cytosol|Golgi membrane|membrane fraction	ATPase binding|beta-tubulin binding|GABA receptor binding|microtubule binding|SNARE binding			lung(1)|ovary(1)	2						TCAGGCTCTCAGATTGTTGAC	0.478000													78	104					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47163179	47163179	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:47163179C>G	ENST00000409792.3	-	3	2989	c.2947G>C	c.(2947-2949)Gaa>Caa	p.E983Q		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	983					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.E983*(1)|p.E480*(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCTCCTCTTTCATCTAAAGAG	0.393000			"""N, F, S, Mis"""		clear cell renal carcinoma								5	116					0	0	1	0	0
DNAJC17	55192	broad.mit.edu	37	15	41068427	41068427	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:41068427G>C	ENST00000220496.4	-	6	475	c.445C>G	c.(445-447)Cag>Gag	p.Q149E		NM_018163.2	NP_060633.1	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	149					protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|skin(1)	6		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		TGGCGTATCTGCTCCCGGATG	0.607000													13	36					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	941650	941650	+	Silent	SNP	C	C	T	rs34645349	byFrequency	TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:941650C>T	ENST00000264771.4	+	2	308	c.123C>T	c.(121-123)gaC>gaT	p.D41D	TMEM175_ENST00000508204.1_Intron|TMEM175_ENST00000515740.1_Intron	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	41						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCTTCAGTGACGCCCTGCTGT	0.672000													48	23					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53756362	53756362	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:53756362C>A	ENST00000288139.3	+	13	1705	c.1587C>A	c.(1585-1587)aaC>aaA	p.N529K	CACNA1D_ENST00000422281.2_Missense_Mutation_p.N509K|CACNA1D_ENST00000350061.5_Missense_Mutation_p.N509K	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	509					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTCGCTGGAACCGATTCAATC	0.448000													35	87					2.05212e-20	2.3274e-20	1	1	0
LSG1	55341	broad.mit.edu	37	3	194390737	194390737	+	Splice_Site	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:194390737C>T	ENST00000265245.5	-	2	541		c.e2+1			NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1						nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		AAACAACTTACCAGCTACAAA	0.443000													38	122					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42874353	42874353	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:42874353G>A	ENST00000334370.4	+	38	7281	c.6646G>A	c.(6646-6648)Gag>Aag	p.E2216K	MEGF8_ENST00000251268.6_Missense_Mutation_p.E2283K|MEGF8_ENST00000378073.4_5'UTR	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2283	EGF-like 5.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CAGCCACTGTGAGCAGTGCCT	0.622000													17	42					0	0	1	0	0
OTUD5	55593	broad.mit.edu	37	X	48781242	48781242	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chrX:48781242G>A	ENST00000156084.4	-	7	1426	c.1366C>T	c.(1366-1368)Cgg>Tgg	p.R456W	OTUD5_ENST00000396743.3_Missense_Mutation_p.R451W|OTUD5_ENST00000376488.3_Missense_Mutation_p.R451W|OTUD5_ENST00000428668.2_Missense_Mutation_p.R234W	NM_017602.3	NP_060072.1	Q96G74	OTUD5_HUMAN	OTU domain containing 5	456					negative regulation of type I interferon production		cysteine-type peptidase activity	p.R427G(1)|p.R456G(1)		endometrium(2)|large_intestine(3)|lung(6)|pancreas(2)	13						GCTGAACTCCGCTGCCGCGGG	0.637000													10	6					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183513602	183513602	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:183513602G>T	ENST00000367537.3	+	16	2101	c.1906G>T	c.(1906-1908)Gga>Tga	p.G636*	SMG7_ENST00000507469.1_Nonsense_Mutation_p.G607*|SMG7_ENST00000456731.2_Nonsense_Mutation_p.G565*|SMG7_ENST00000515829.2_Nonsense_Mutation_p.G607*|SMG7_ENST00000508461.1_Nonsense_Mutation_p.G611*|SMG7_ENST00000347615.2_Nonsense_Mutation_p.G653*			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	653					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TCATCACCCTGGAGCCTTCCC	0.423000													77	42					1.39921e-30	1.65766e-30	1	1	0
ARHGAP24	83478	broad.mit.edu	37	4	86916451	86916451	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:86916451G>C	ENST00000395184.1	+	9	2110	c.1644G>C	c.(1642-1644)caG>caC	p.Q548H	ARHGAP24_ENST00000264343.4_Missense_Mutation_p.Q455H|ARHGAP24_ENST00000395183.2_Missense_Mutation_p.Q453H	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	548					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		ATGACAAGCAGAGCATTGACA	0.502000													30	59					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23306136	23306136	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:23306136G>C	ENST00000381990.2	+	7	1216	c.1055G>C	c.(1054-1056)gGa>gCa	p.G352A	GPNMB_ENST00000258733.4_Splice_Site_p.G340_splice|GPNMB_ENST00000539136.1_Splice_Site_p.G241_splice|GPNMB_ENST00000453162.2_Missense_Mutation_p.G294A	NM_001005340.1|NM_002510.2	NP_001005340.1|NP_002501.1	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	352					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			AACACCCCAGGACCTGCTGGT	0.388000													24	94					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88658688	88658688	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:88658688T>A	ENST00000340700.5	-	5	1184	c.733A>T	c.(733-735)Att>Ttt	p.I245F	KCNK10_ENST00000319231.5_Missense_Mutation_p.I250F|KCNK10_ENST00000312350.5_Missense_Mutation_p.I250F	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	245					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						ACAAACACAATGCAGCCGGCC	0.502000													9	62					0	0	1	0	0
ISYNA1	51477	broad.mit.edu	37	19	18546692	18546692	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:18546692C>A	ENST00000545187.1	-	5	851	c.565G>T	c.(565-567)Gat>Tat	p.D189Y	ISYNA1_ENST00000457269.3_Missense_Mutation_p.D285Y|ISYNA1_ENST00000578963.1_Missense_Mutation_p.D211Y|ISYNA1_ENST00000317018.6_Missense_Mutation_p.D137Y|ISYNA1_ENST00000338128.7_Missense_Mutation_p.D339Y			Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	339					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			breast(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	12						TTCTCCCCATCGTTGTTGCCC	0.592000													7	201					2.7689e-08	2.89334e-08	1	1	0
SLC22A11	55867	broad.mit.edu	37	11	64335155	64335155	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:64335155C>T	ENST00000301891.4	+	7	1517	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	SLC22A11_ENST00000377581.3_Silent_p.F381F|SLC22A11_ENST00000377585.3_Intron	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	381					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	AGGCCCTCTTCGGGGCCGTGG	0.652000													44	76					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45480359	45480359	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:45480359G>A	ENST00000334940.6	+	6	633	c.499G>A	c.(499-501)Gag>Aag	p.E167K	RASSF4_ENST00000374417.2_Silent_p.*127*|RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000340258.4_Missense_Mutation_p.E158K			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	158					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CGCCCCCGGTGAGGCCCAGCG	0.672000													54	101					0	0	1	0	0
PPP2R5E	5529	broad.mit.edu	37	14	63858695	63858695	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:63858695C>T	ENST00000337537.3	-	9	1500	c.898G>A	c.(898-900)Gaa>Aaa	p.E300K	PPP2R5E_ENST00000553266.1_5'UTR|PPP2R5E_ENST00000555899.1_Missense_Mutation_p.E300K|PPP2R5E_ENST00000422769.2_Missense_Mutation_p.E224K	NM_006246.2	NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	300					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CTTACTGGTTCTGTGAGTGAA	0.289000													12	42					0	0	1	0	0
LOC728554	728554	broad.mit.edu	37	5	177310701	177310701	+	RNA	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr5:177310701C>G	ENST00000506672.1	+	0	998					NR_003615.2																						TGTGAGTCTCCGACCTTCACA	0.473000													8	41					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680442	114680442	+	Missense_Mutation	SNP	C	C	A	rs139165674	byFrequency	TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:114680442C>A	ENST00000393296.1	-	3	823	c.746G>T	c.(745-747)cGt>cTt	p.R249L	SYT6_ENST00000369547.1_Missense_Mutation_p.R164L			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	249	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity	p.R164H(2)		central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAGGATACGCACAATCAG	0.542000													41	72					7.63091e-17	8.4991e-17	1	1	0
GSG1	83445	broad.mit.edu	37	12	13243575	13243575	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:13243575C>A	ENST00000337630.6	-	2	254	c.187G>T	c.(187-189)Gtg>Ttg	p.V63L	GSG1_ENST00000457134.2_Missense_Mutation_p.V63L|GSG1_ENST00000396302.3_Missense_Mutation_p.V63L|GSG1_ENST00000432710.2_Missense_Mutation_p.V76L|GSG1_ENST00000537302.1_Missense_Mutation_p.V63L|GSG1_ENST00000396310.2_Missense_Mutation_p.V60L|GSG1_ENST00000324458.8_Missense_Mutation_p.V76L|GSG1_ENST00000351606.6_Missense_Mutation_p.V76L	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	63						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TCCAGGGACACTGGCATGTCA	0.567000													35	86					1.26612e-14	1.38528e-14	1	1	0
NPHS1	4868	broad.mit.edu	37	19	36336673	36336673	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:36336673G>T	ENST00000378910.5	-	13	1654	c.1655C>A	c.(1654-1656)gCc>gAc	p.A552D	NPHS1_ENST00000353632.6_Missense_Mutation_p.A552D	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	552	Ig-like C2-type 6.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGATGCGTTGGCCAGGATCGT	0.637000													10	34					5.50884e-06	5.66101e-06	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144921929	144921929	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:144921929C>T	ENST00000529945.1	-	5	2028	c.1589G>A	c.(1588-1590)cGc>cAc	p.R530H	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R367H|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R433H|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R367H|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R367H|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R367H|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R530H|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.R504H|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.R154H|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R504H			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	367					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGCCAGTTGGCGCTCTTTCTG	0.478000			T	PDGFRB	MPD								7	693					0	0	1	0	0
DHODH	1723	broad.mit.edu	37	16	72057134	72057134	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:72057134G>A	ENST00000572887.1	+	7	1067	c.890G>A	c.(889-891)cGc>cAc	p.R297H	DHODH_ENST00000219240.4_Missense_Mutation_p.R297H|DHODH_ENST00000573922.1_3'UTR			Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase (quinone)	297					'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity			breast(1)|endometrium(2)|large_intestine(4)|ovary(1)|skin(1)|stomach(1)	10		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GGTGCCCTGCGCTCTGAAACA	0.562000													33	39					0	0	1	0	0
RASL10A	10633	broad.mit.edu	37	22	29709456	29709456	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr22:29709456C>G	ENST00000216101.6	-	3	955	c.446G>C	c.(445-447)cGc>cCc	p.R149P	RASL10A_ENST00000401450.3_3'UTR	NM_006477.4	NP_006468.1	Q92737	RSLAA_HUMAN	RAS-like, family 10, member A	149	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)	1						CCAGCCCCTGCGCACTAGGGC	0.736000													4	4					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7214103	7214103	+	Silent	SNP	G	G	A	rs149003494		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:7214103G>A	ENST00000361972.4	-	19	2259	c.2169C>T	c.(2167-2169)gaC>gaT	p.D723D	SFMBT2_ENST00000397167.1_Silent_p.D723D	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	723					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						TGGCGTCAGCGTCCTCCTCTT	0.682000													7	26					0	0	1	0	0
E2F5	1875	broad.mit.edu	37	8	86126067	86126067	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:86126067T>G	ENST00000418930.2	+	8	1204	c.1008T>G	c.(1006-1008)gaT>gaG	p.D336E	E2F5_ENST00000519128.1_3'UTR|E2F5_ENST00000416274.2_Missense_Mutation_p.D337E|E2F5_ENST00000517476.1_Missense_Mutation_p.D176E|E2F5_ENST00000256117.5_Missense_Mutation_p.D338E|E2F5_ENST00000521429.1_Missense_Mutation_p.D164E			Q15329	E2F5_HUMAN	E2F transcription factor 5, p130-binding	337	RBL2 association (Potential).|Transactivation (Potential).				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			NS(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	8						GAGTTTGTGATCTGTTTGATG	0.348000													16	38					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	21000492	21000492	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:21000492A>C	ENST00000274695.4	+	11	1111	c.944A>C	c.(943-945)tAc>tCc	p.Y315S	CDKAL1_ENST00000378610.1_Missense_Mutation_p.Y315S|CDKAL1_ENST00000378624.4_Missense_Mutation_p.Y245S	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	315					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CCCAGAGTCTACGCTTTTCTG	0.393000													52	136					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45475316	45475316	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:45475316C>G	ENST00000361462.2	+	5	2933	c.2750C>G	c.(2749-2751)cCa>cGa	p.P917R	FAM179B_ENST00000361577.3_Missense_Mutation_p.P917R|FAM179B_ENST00000382233.2_Missense_Mutation_p.P917R|KLHL28_ENST00000553817.1_Intron			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	917							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CCTCCCATACCAAGGGGAATA	0.438000													44	90					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38565632	38565632	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:38565632G>T	ENST00000287675.5	+	6	982	c.886G>T	c.(886-888)Gtg>Ttg	p.V296L	EXOG_ENST00000422077.2_Missense_Mutation_p.V246L|EXOG_ENST00000358249.2_Intron	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	296						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						TATCTGCTCTGTGGACACCTG	0.448000													82	158					2.05912e-35	2.48699e-35	1	1	0
PPM1B	5495	broad.mit.edu	37	2	44459467	44459467	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:44459467C>G	ENST00000378551.2	+	6	1559	c.1147C>G	c.(1147-1149)Cta>Gta	p.L383V	PPM1B_ENST00000378540.4_Intron	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	383					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGCTGGAGATCTAGAAGACCC	0.333000													31	72					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33092942	33092942	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:33092942T>C	ENST00000306065.4	-	26	2904	c.2746A>G	c.(2746-2748)Act>Gct	p.T916A		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	916					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					ATCTTAACAGTGACATACTCC	0.378000													46	88					0	0	1	0	0
TMEM68	137695	broad.mit.edu	37	8	56652716	56652716	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:56652716C>G	ENST00000434581.2	-	8	1149	c.950G>C	c.(949-951)aGt>aCt	p.S317T	TMEM68_ENST00000334667.2_Missense_Mutation_p.S250T|TMEM68_ENST00000519784.1_Missense_Mutation_p.S136T			Q96MH6	TMM68_HUMAN	transmembrane protein 68	317						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			TAACAAAGCACTCATAATGTT	0.308000													4	142					0	0	1	0	0
AMER2	219287	broad.mit.edu	37	13	25745572	25745572	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:25745572C>T	ENST00000357816.2	-	2	661	c.186G>A	c.(184-186)aaG>aaA	p.K62K	AMER2_ENST00000381853.3_Silent_p.K62K|AMER2_ENST00000515384.1_Silent_p.K62K					APC membrane recruitment protein 2																		CTTTATTAATCTTCCCCGACG	0.597000													14	31					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298223	42298223	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:42298223T>G	ENST00000399518.3	-	4	976	c.490A>C	c.(490-492)Aag>Cag	p.K164Q	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.K135Q	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	146					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		TGGGTTTTCTTTCGGAAACAG	0.507000													10	53					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160846552	160846552	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:160846552C>G	ENST00000326245.3	-	8	959	c.844G>C	c.(844-846)Gat>Cat	p.D282H		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	282					positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAGAAAAATCTCCACACTGC	0.483000													36	99					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30822217	30822217	+	Splice_Site	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr12:30822217C>G	ENST00000256079.4	-	10	1383		c.e10-1		IPO8_ENST00000544829.1_Splice_Site	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8						intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CAGAGATATTCTAAAATGAGA	0.308000													25	31					0	0	1	0	0
RNASE13	440163	broad.mit.edu	37	14	21502043	21502043	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:21502043G>C	ENST00000382951.3	-	2	542	c.405C>G	c.(403-405)taC>taG	p.Y135*	NDRG2_ENST00000403829.3_Intron|RP11-998D10.1_ENST00000531638.1_3'UTR	NM_001012264.3	NP_001012264.1	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 (non-active)	135						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			cervix(1)|endometrium(1)|lung(5)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	12	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		AGCAGAGTAGGTAGAGCTTCT	0.532000													61	115					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37229640	37229640	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:37229640T>A	ENST00000233099.5	-	32	5221	c.5126A>T	c.(5125-5127)aAa>aTa	p.K1709I	HEATR5B_ENST00000354531.2_Intron	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1709							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				CACAAGAGATTTTCCAGGAAT	0.443000													33	69					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138221913	138221913	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr5:138221913G>C	ENST00000302763.7	+	8	1165	c.1075G>C	c.(1075-1077)Gaa>Caa	p.E359Q	CTNNA1_ENST00000355078.5_Missense_Mutation_p.E256Q|CTNNA1_ENST00000540387.1_5'UTR|CTNNA1_ENST00000520400.1_3'UTR|CTNNA1_ENST00000518825.1_Missense_Mutation_p.E359Q	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	359	Interaction with alpha-actinin.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGGACGTAAAGAAAGAAGTGA	0.378000													36	33					0	0	1	0	0
PDS5B	23047	broad.mit.edu	37	13	33332780	33332780	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:33332780C>A	ENST00000315596.10	+	28	3484	c.3298C>A	c.(3298-3300)Caa>Aaa	p.Q1100K		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1100					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TTTCTTCACTCAACCTGACAA	0.383000													40	96					1.32136e-16	1.46293e-16	1	1	0
GJC1	10052	broad.mit.edu	37	17	42882287	42882287	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr17:42882287T>A	ENST00000426548.1	-	3	1168	c.899A>T	c.(898-900)cAg>cTg	p.Q300L	GJC1_ENST00000330514.4_Missense_Mutation_p.Q300L|GJC1_ENST00000592524.1_Missense_Mutation_p.Q300L|GJC1_ENST00000590758.1_Missense_Mutation_p.Q300L	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	300					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				TTCGGTGTACTGGATTTGATC	0.488000													70	158					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82336850	82336850	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:82336850C>G	ENST00000329713.4	-	2	796	c.361G>C	c.(361-363)Gcc>Ccc	p.A121P	MEX3B_ENST00000558133.1_3'UTR	NM_032246.3	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	121	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CGAGCCATGGCCACATCCTCC	0.592000													54	38					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167031787	167031787	+	Silent	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:167031787A>G	ENST00000392766.2	-	16	1732	c.1392T>C	c.(1390-1392)tcT>tcC	p.S464S	ZBBX_ENST00000392767.2_Silent_p.S464S|ZBBX_ENST00000307529.5_Silent_p.S464S|ZBBX_ENST00000392764.1_Silent_p.S435S|ZBBX_ENST00000455345.2_Silent_p.S464S	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	464						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TATAATAAGTAGAGCTGTTTC	0.308000													65	160					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36003524	36003524	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:36003524C>T	ENST00000339686.3	-	2	771	c.595G>A	c.(595-597)Gga>Aga	p.G199R	DMKN_ENST00000440396.1_Missense_Mutation_p.G199R|DMKN_ENST00000424570.2_Missense_Mutation_p.G199R|DMKN_ENST00000419602.1_Missense_Mutation_p.G199R|DMKN_ENST00000451297.2_Missense_Mutation_p.G199R|DMKN_ENST00000447113.2_Missense_Mutation_p.G199R|DMKN_ENST00000429837.1_Missense_Mutation_p.G199R|DMKN_ENST00000418261.1_Missense_Mutation_p.G199R	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	199	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GGTGGCCCTCCATTGCCTCCT	0.612000													37	58					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64335076	64335076	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:64335076C>T	ENST00000301891.4	+	7	1438	c.1064C>T	c.(1063-1065)tCt>tTt	p.S355F	SLC22A11_ENST00000377581.3_Missense_Mutation_p.S355F|SLC22A11_ENST00000377585.3_Intron	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	355					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	CGCAGTTTCTCTCTATTGATC	0.637000													53	100					0	0	1	0	0
ENOSF1	55556	broad.mit.edu	37	18	678725	678725	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr18:678725A>T	ENST00000319815.6	-	4	1463	c.199T>A	c.(199-201)Tta>Ata	p.L67I	ENOSF1_ENST00000251101.7_Missense_Mutation_p.L297I|ENOSF1_ENST00000583973.1_5'UTR|ENOSF1_ENST00000580982.1_Missense_Mutation_p.L221I|ENOSF1_ENST00000383578.3_Missense_Mutation_p.L215I|ENOSF1_ENST00000340116.7_Intron			Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	297					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						CCAATTCCTAATGGGACCAGT	0.478000													4	150					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67855743	67855743	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:67855743C>T	ENST00000262345.1	+	15	2618	c.1978C>T	c.(1978-1980)Cag>Tag	p.Q660*	IL12RB2_ENST00000465396.1_3'UTR|IL12RB2_ENST00000541374.1_Intron|IL12RB2_ENST00000544434.1_Nonsense_Mutation_p.Q574*|IL12RB2_ENST00000371000.1_Intron	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	660					positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						CCTCAGACCTCAGTGGTGTAG	0.463000													24	51					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38084919	38084919	+	Silent	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr21:38084919C>G	ENST00000290399.6	+	3	958	c.345C>G	c.(343-345)tcC>tcG	p.S115S	SIM2_ENST00000430056.3_Silent_p.S115S	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	115	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TAGGCTTATCCCAGGTGGGTA	0.378000													34	57					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237794734	237794734	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:237794734A>C	ENST00000366574.2	+	42	6765	c.6448A>C	c.(6448-6450)Atg>Ctg	p.M2150L	RYR2_ENST00000360064.6_Missense_Mutation_p.M2148L|RYR2_ENST00000542537.1_Missense_Mutation_p.M2134L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2150	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAGGGATATTATGAATAACAA	0.413000													4	16					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	110267	110267	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:110267C>T	ENST00000262316.6	-	13	1811	c.1669G>A	c.(1669-1671)Gag>Aag	p.E557K		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	557					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GAGGAGGGCTCATCACACACC	0.602000													23	33					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113653031	113653031	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:113653031G>T	ENST00000361127.4	+	13	1843	c.1645G>T	c.(1645-1647)Gtt>Ttt	p.V549F	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	549	Ig-like C2-type 1.					cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TGAGAATTTTGTTCGTTATTG	0.423000													60	127					2.93687e-30	3.45733e-30	1	1	0
TTC21A	199223	broad.mit.edu	37	3	39167822	39167822	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:39167822A>G	ENST00000301819.6	+	12	1664	c.1487A>G	c.(1486-1488)aAa>aGa	p.K496R	TTC21A_ENST00000440121.1_Missense_Mutation_p.K447R|TTC21A_ENST00000431162.2_Missense_Mutation_p.K496R	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	496							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCTGTAGTCAAAGCAGCACCA	0.567000													6	76					0	0	1	0	0
GNRHR	2798	broad.mit.edu	37	4	68619925	68619925	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:68619925G>A	ENST00000226413.4	-	1	153	c.129C>T	c.(127-129)ttC>ttT	p.F43F	GNRHR_ENST00000420975.2_Silent_p.F43F|RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000502758.1_RNA	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	43					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GAAAAAGGAAGAAAGTAACCG	0.443000													31	72					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45929191	45929191	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr21:45929191C>T	ENST00000323084.4	-	10	1710	c.1645G>A	c.(1645-1647)Gat>Aat	p.D549N	TSPEAR-AS1_ENST00000451035.1_RNA|TSPEAR_ENST00000397916.1_Missense_Mutation_p.D481N	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	549					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ATCTCCACATCGTAGCTGTGA	0.532000													16	28					0	0	1	0	0
HDAC8	55869	broad.mit.edu	37	X	71694509	71694509	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chrX:71694509C>T	ENST00000373561.4	-	10	1150	c.809G>A	c.(808-810)aGc>aAc	p.S270N	HDAC8_ENST00000373573.3_Intron|HDAC8_ENST00000373560.2_3'UTR|HDAC8_ENST00000429103.2_Intron|HDAC8_ENST00000373571.1_Intron|HDAC8_ENST00000373589.4_Intron|HDAC8_ENST00000373583.1_Intron|HDAC8_ENST00000439122.2_3'UTR|HDAC8_ENST00000373559.4_3'UTR			Q9BY41	HDAC8_HUMAN	histone deacetylase 8	0	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	TCAGACAAGGCTATGCAAATG	0.443000													15	56					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38938649	38938649	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:38938649G>C	ENST00000302328.3	-	14	2288	c.2090C>G	c.(2089-2091)tCt>tGt	p.S697C	SCN11A_ENST00000444237.2_Missense_Mutation_p.S697C|SCN11A_ENST00000450244.1_Missense_Mutation_p.S697C|SCN11A_ENST00000456224.3_Missense_Mutation_p.S697C	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	697					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGCTCCGACAGAGTTGCCGAT	0.433000													31	38					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140990941	140990941	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr9:140990941G>C	ENST00000277549.5	+	37	5251	c.2682G>C	c.(2680-2682)ttG>ttC	p.L894F	CACNA1B_ENST00000371363.1_Missense_Mutation_p.L1698F|CACNA1B_ENST00000371365.2_Missense_Mutation_p.L64F|CACNA1B_ENST00000371355.4_Missense_Mutation_p.L1701F|CACNA1B_ENST00000371372.1_Missense_Mutation_p.L1700F|CACNA1B_ENST00000371357.1_Missense_Mutation_p.L1699F|CACNA1B_ENST00000277551.2_Missense_Mutation_p.L1700F			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1700					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGCAGATGTTGAACCTCTTTG	0.572000													25	68					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28233203	28233203	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:28233203T>A	ENST00000305242.5	-	12	1783	c.1691A>T	c.(1690-1692)aAg>aTg	p.K564M	ARMC4_ENST00000545014.1_Missense_Mutation_p.K89M|ARMC4_ENST00000537576.1_Missense_Mutation_p.K256M	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	564							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCTTTTAAACTTGGCAACATT	0.498000													20	31					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37368468	37368468	+	Silent	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:37368468A>T	ENST00000361924.2	+	14	5465	c.5091A>T	c.(5089-5091)tcA>tcT	p.S1697S	GOLGA4_ENST00000356847.4_Silent_p.S1719S|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1697	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AACTTAAGTCAGTGGAAAGTT	0.378000													65	107					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149523244	149523244	+	RNA	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:149523244C>T	ENST00000378016.2	+	0	14330							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGCAGTTGCTCGGCCCCCTGT	0.647000													53	57					0	0	1	0	0
CWF19L2	143884	broad.mit.edu	37	11	107219718	107219718	+	Nonsense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:107219718A>T	ENST00000282251.5	-	14	2174	c.2147T>A	c.(2146-2148)tTg>tAg	p.L716*	CWF19L2_ENST00000433523.1_Nonsense_Mutation_p.L716*	NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	716							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		ATGGTGCTGCAAAGGGACTAT	0.388000													12	29					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204210863	204210863	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:204210863A>C	ENST00000272203.3	-	16	2568	c.2252T>G	c.(2251-2253)gTg>gGg	p.V751G	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.V771G	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	751										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CCTGGTGGGCACAAGGCTGAT	0.542000													38	54					0	0	1	0	0
CRISP1	167	broad.mit.edu	37	6	49819806	49819806	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:49819806T>A	ENST00000335847.4	-	3	204	c.103A>T	c.(103-105)Acc>Tcc	p.T35S	CRISP1_ENST00000536021.1_Missense_Mutation_p.T35S|CRISP1_ENST00000355791.2_Missense_Mutation_p.T35S|CRISP1_ENST00000507853.1_Missense_Mutation_p.T35S|CRISP1_ENST00000505118.1_Missense_Mutation_p.T35S|CRISP1_ENST00000329411.5_Missense_Mutation_p.T35S	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	35					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					GGCAAGTCGGTGACGAGCTTA	0.373000													42	103					0	0	1	0	0
FAF1	11124	broad.mit.edu	37	1	51049377	51049377	+	Silent	SNP	G	G	A	rs140546895		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:51049377G>A	ENST00000396153.2	-	11	1429	c.978C>T	c.(976-978)aaC>aaT	p.N326N	FAF1_ENST00000545823.1_Silent_p.N84N|FAF1_ENST00000472808.1_5'UTR|FAF1_ENST00000371778.4_Silent_p.N326N	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	326					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.N326N(1)|p.0?(1)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		CATTTTCTGCGTTTTCTGGCA	0.294000													21	21					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058168	11058168	+	RNA	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr21:11058168A>T	ENST00000470054.1	-	0	479									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACATCTTTCAGGAGCTTGGT	0.388000													4	128					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245335	59245335	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:59245335A>G	ENST00000530162.1	+	1	490	c.433A>G	c.(433-435)Aca>Gca	p.T145A		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CATTGGGCTCACAGTGGCTGC	0.512000													43	76					0	0	1	0	0
CSAG4	100130935	broad.mit.edu	37	X	151896589	151896589	+	RNA	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chrX:151896589C>A	ENST00000361201.4	-	0	351					NR_073432.1													p.L11F(1)		endometrium(2)|kidney(2)|lung(1)	5						GGTTGTTGGACAATGGGCTGG	0.557000													5	225					8.12818e-05	8.21653e-05	1	1	0
MAMLD1	10046	broad.mit.edu	37	X	149639635	149639635	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chrX:149639635A>T	ENST00000370401.2	+	4	2100	c.1790A>T	c.(1789-1791)cAg>cTg	p.Q597L	MAMLD1_ENST00000262858.5_Missense_Mutation_p.Q597L|MAMLD1_ENST00000426613.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000432680.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000455522.2_Missense_Mutation_p.Q78L			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	597	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TTgcagctgcagcagcagcag	0.607000													5	132					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86601504	86601504	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:86601504C>T	ENST00000320354.4	+	1	648	c.563C>T	c.(562-564)cCg>cTg	p.P188L		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	188					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						GAGCCGCCCCCGGCGGCGTCC	0.701000									Late-onset Hereditary Lymphedema				17	37					0	0	1	0	0
RASA4B	100271927	broad.mit.edu	37	7	102136604	102136604	+	Missense_Mutation	SNP	C	C	T	rs746316		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:102136604C>T	ENST00000481893.1	-	16	1962	c.838G>A	c.(838-840)Gtg>Atg	p.V280M	RASA4B_ENST00000465829.1_Missense_Mutation_p.V352M|RASA4B_ENST00000541662.1_Missense_Mutation_p.V352M|RASA4B_ENST00000306682.6_Missense_Mutation_p.V280M					RAS p21 protein activator 4B									p.V352M(1)		skin(1)	1						AAAGACTCCACGGACTTTGAG	0.542000													5	145					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677735	149677735	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr5:149677735C>T	ENST00000328668.7	-	2	1331	c.752G>A	c.(751-753)cGc>cAc	p.R251H		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	251						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTGCGGTAGCGGTACAGGTA	0.627000													14	46					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44567730	44567730	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr20:44567730C>G	ENST00000372409.3	+	3	456	c.92C>G	c.(91-93)cCa>cGa	p.P31R		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	31						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						CCCTGTTCTCCAAAGCCAATC	0.632000													22	49					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													8	479					0	0	1	0	0
NMT2	9397	broad.mit.edu	37	10	15183456	15183456	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:15183456C>G	ENST00000378165.4	-	2	291	c.211G>C	c.(211-213)Gat>Cat	p.D71H	NMT2_ENST00000378150.1_Silent_p.L43L|NMT2_ENST00000535341.1_Silent_p.L43L|NMT2_ENST00000540259.1_5'UTR	NM_004808.2	NP_004799.1	O60551	NMT2_HUMAN	N-myristoyltransferase 2	71					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			breast(3)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(3)	21						TCCTGGGAATCAGATGCCGAG	0.433000													18	49					0	0	1	0	0
STH	246744	broad.mit.edu	37	17	44076946	44076946	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr17:44076946C>G	ENST00000537309.1	+	1	331	c.301C>G	c.(301-303)Cag>Gag	p.Q101E	MAPT_ENST00000340799.5_Intron|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000262410.5_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000574436.1_Intron|MAPT_ENST00000571987.1_Intron|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000344290.5_Intron|MAPT_ENST00000415613.2_Intron|MAPT_ENST00000576518.1_Intron	NM_001007532.2	NP_001007533.1	Q8IWL8	STH_HUMAN	saitohin	101						cytoplasm|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						AGGCCCCTTTCAGGGCCAGAA	0.587000													7	23					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133623563	133623563	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:133623563C>T	ENST00000519595.1	-	9	1119	c.1021G>A	c.(1021-1023)Gtg>Atg	p.V341M	LRRC6_ENST00000518642.1_Missense_Mutation_p.V341M|LRRC6_ENST00000250173.1_Missense_Mutation_p.V341M			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	341	CS.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATTACTCGCACGTAAGTTGGT	0.318000													61	41					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32786429	32786429	+	Splice_Site	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:32786429G>A	ENST00000380250.3	+	35	5088	c.4591_splice	c.e35-1	p.G1531_splice		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1531					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCATCTACAGGAACCACCTCT	0.418000													12	14					0	0	1	0	0
IFI27	3429	broad.mit.edu	37	14	94578103	94578103	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr14:94578103C>T	ENST00000555744.1	+	2	263	c.75C>T	c.(73-75)gcC>gcT	p.A25A	IFI27_ENST00000444961.1_Silent_p.A25A|IFI27_ENST00000298902.5_Silent_p.A25A|IFI27_ENST00000557098.1_Intron|IFI27_ENST00000557634.1_Silent_p.A25A|IFI27_ENST00000448882.1_Silent_p.A25A			P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27	25					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion				breast(1)|lung(3)	4				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		CTGGCTCTGCCGTAGTTTTGC	0.662000													17	25					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375708	93375708	+	Silent	SNP	G	G	A	rs76821927		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr9:93375708G>A	ENST00000375765.3	-	2	790	c.402C>T	c.(400-402)agC>agT	p.S134S		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	134					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						CCTCCGCCTCGCTGCTCTGCA	0.582000													36	51					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45412980	45412980	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:45412980C>G	ENST00000558996.1	-	4	283	c.229G>C	c.(229-231)Gag>Cag	p.E77Q	DUOXA1_ENST00000267803.4_Missense_Mutation_p.E122Q|DUOXA1_ENST00000430224.2_Missense_Mutation_p.E77Q|DUOXA1_ENST00000560572.1_Missense_Mutation_p.E122Q|DUOXA1_ENST00000559014.1_Missense_Mutation_p.E122Q|DUOXA1_ENST00000558422.1_Missense_Mutation_p.E77Q	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	122					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TTGATGGTCTCATTCAGCTGC	0.592000													55	120					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21992531	21992531	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:21992531C>G	ENST00000594012.1	-	7	804	c.290G>C	c.(289-291)aGa>aCa	p.R97T	ZNF43_ENST00000354959.4_Missense_Mutation_p.R103T|ZNF43_ENST00000598381.1_Missense_Mutation_p.R97T|ZNF43_ENST00000595461.1_Missense_Mutation_p.R97T	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GTTTTTATATCTTCTCAGTGT	0.318000													15	78					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46807198	46807198	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:46807198C>T	ENST00000377670.4	+	2	101	c.70C>T	c.(70-72)Cgc>Tgc	p.R24C	HIF3A_ENST00000300862.3_Missense_Mutation_p.R22C|HIF3A_ENST00000420102.2_Silent_p.P21P|HIF3A_ENST00000339613.2_5'UTR|HIF3A_ENST00000600383.1_Silent_p.P3P|HIF3A_ENST00000472815.1_Silent_p.P3P|HIF3A_ENST00000244303.6_Silent_p.P3P	NM_152795.3	NP_690008.2	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGATGCGGCCCGCAGCCGGCG	0.657000													4	15					0	0	1	0	0
ZBTB3	79842	broad.mit.edu	37	11	62520867	62520867	+	Silent	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr11:62520867C>G	ENST00000394807.3	-	2	545	c.420G>C	c.(418-420)ctG>ctC	p.L140L		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	140	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						TATCCCCTCTCAGGGTCAGCT	0.547000													42	77					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132862907	132862907	+	Splice_Site	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr9:132862907G>A	ENST00000372406.1	+	11	1446		c.e11-1		GPR107_ENST00000347136.6_Splice_Site|GPR107_ENST00000372410.3_Splice_Site	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107							integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TTTGATTTCAGATTGACTACC	0.408000													61	109					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103364278	103364278	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:103364278G>A	ENST00000358392.2	-	56	4545	c.4228C>T	c.(4228-4230)Cag>Tag	p.Q1410*	COL11A1_ENST00000512756.1_Nonsense_Mutation_p.Q1282*|COL11A1_ENST00000353414.4_Nonsense_Mutation_p.Q1359*|COL11A1_ENST00000370096.3_Nonsense_Mutation_p.Q1398*	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1398	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCAGGTCCCTGAGGACCGACT	0.478000													24	34					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840472	142840472	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:142840472G>A	ENST00000309575.3	+	2	2198	c.814G>A	c.(814-816)Gtg>Atg	p.V272M		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	272					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						CAAGGAGGTCGTGGGGTTGGT	0.657000													7	16					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51773320	51773320	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr15:51773320C>G	ENST00000251076.5	-	24	6270	c.5983G>C	c.(5983-5985)Ggt>Cgt	p.G1995R	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.G1359R|DMXL2_ENST00000543779.2_Missense_Mutation_p.G1995R	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1995						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATCACTAAACCAACAGCATCG	0.423000													23	239					0	0	1	0	0
FUCA2	2519	broad.mit.edu	37	6	143823693	143823693	+	Silent	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:143823693C>A	ENST00000002165.5	-	4	817	c.762G>T	c.(760-762)cgG>cgT	p.R254R	FUCA2_ENST00000367585.1_Intron|FUCA2_ENST00000438118.2_Intron|RP1-20N2.6_ENST00000591892.1_RNA|RP1-20N2.6_ENST00000589563.1_RNA	NM_032020.4	NP_114409.2	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma	254					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CTACTGTGCCCCGAACTGGGC	0.383000													33	16					4.11147e-13	4.42043e-13	1	1	0
VWA8	23078	broad.mit.edu	37	13	42259355	42259355	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:42259355C>A	ENST00000379310.3	-	35	4223	c.4155G>T	c.(4153-4155)tgG>tgT	p.W1385C		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		ATGGTCTCTTCCAAGAATAAA	0.383000													16	44					2.35188e-11	2.49971e-11	1	1	0
SCNN1B	6338	broad.mit.edu	37	16	23364196	23364196	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:23364196C>G	ENST00000343070.2	+	3	562	c.386C>G	c.(385-387)cCt>cGt	p.P129R	SCNN1B_ENST00000307331.5_Missense_Mutation_p.P174R|SCNN1B_ENST00000568923.1_Missense_Mutation_p.P129R|SCNN1B_ENST00000568085.1_Missense_Mutation_p.P129R|SCNN1B_ENST00000569789.1_3'UTR	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	129					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	ATCCTGGCTCCTGAGCTAAGC	0.542000													42	59					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904393	180904393	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:180904393G>A	ENST00000367588.4	+	5	1403	c.1348G>A	c.(1348-1350)Gtg>Atg	p.V450M	KIAA1614_ENST00000367587.1_Missense_Mutation_p.V71M	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	450										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GCCGTCGCACGTGCGCTTTGA	0.701000													4	9					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26203812	26203812	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:26203812C>T	ENST00000264712.3	-	1	1554	c.975G>A	c.(973-975)ctG>ctA	p.L325L	KIF3C_ENST00000405914.1_Silent_p.L325L	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	325	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTCCTGGAGCAGCCGGGTCA	0.597000													18	54					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6978337	6978337	+	Silent	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr18:6978337C>T	ENST00000389658.3	-	43	6141	c.6048G>A	c.(6046-6048)acG>acA	p.T2016T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2016	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding	p.T2016T(1)		NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTTGCAGACGTGGCCAGCT	0.512000													24	111					0	0	1	0	0
MED15	51586	broad.mit.edu	37	22	20937129	20937129	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr22:20937129C>T	ENST00000263205.7	+	11	1481	c.1412C>T	c.(1411-1413)tCt>tTt	p.S471F	MED15_ENST00000542773.1_Intron|MED15_ENST00000406969.1_Missense_Mutation_p.S405F|MED15_ENST00000292733.7_Missense_Mutation_p.S431F|MED15_ENST00000425759.2_Missense_Mutation_p.S320F|MED15_ENST00000541476.1_Missense_Mutation_p.S405F|MED15_ENST00000478831.1_3'UTR|MED15_ENST00000382974.2_Missense_Mutation_p.S360F	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	471	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			GGCTGCAGCTCTGGCCCTGCC	0.692000													42	65					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192213	211192213	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:211192213A>T	ENST00000367007.4	-	6	1113	c.944T>A	c.(943-945)gTg>gAg	p.V315E	KCNH1_ENST00000271751.4_Missense_Mutation_p.V315E	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	315					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AACCTCATCCACGTTCTCAAA	0.478000													14	114					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14273620	14273620	+	Silent	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr19:14273620G>A	ENST00000340736.6	-	6	1305	c.1008C>T	c.(1006-1008)gaC>gaT	p.D336D	CTB-55O6.12_ENST00000592086.1_RNA|LPHN1_ENST00000361434.3_Silent_p.D331D|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	336	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCGCCTCGCTGTCATCATCCA	0.607000													19	42					0	0	1	0	0
PCBP1	5093	broad.mit.edu	37	2	70315482	70315482	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr2:70315482G>A	ENST00000303577.5	+	1	898	c.607G>A	c.(607-609)Gac>Aac	p.D203N	PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	203					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						TCGGTGCAGCGACGCTGCGGG	0.627000													25	42					0	0	1	0	0
MAP7D1	55700	broad.mit.edu	37	1	36643562	36643562	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:36643562C>G	ENST00000316156.4	+	8	1810	c.1357C>G	c.(1357-1359)Ctg>Gtg	p.L453V	MAP7D1_ENST00000373150.4_Missense_Mutation_p.L458V|MAP7D1_ENST00000373151.2_Missense_Mutation_p.L490V|MAP7D1_ENST00000373148.4_Missense_Mutation_p.L36V			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	490						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				AGGCCACACTCTGCCTCCAAA	0.682000													23	35					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100459413	100459413	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:100459413C>T	ENST00000354161.3	+	12	1716	c.1591C>T	c.(1591-1593)Cgg>Tgg	p.R531W	SLC12A9_ENST00000540482.1_Missense_Mutation_p.R531W|SLC12A9_ENST00000275729.3_Missense_Mutation_p.R442W|SLC12A9_ENST00000415287.1_Missense_Mutation_p.R442W|SLC12A9_ENST00000428758.1_Missense_Mutation_p.R531W	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	531						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GAAGTTCTGGCGGCCCCAGCT	0.632000													4	126					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59514673	59514673	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:59514673G>A	ENST00000038176.3	-	14	1281	c.1069C>T	c.(1069-1071)Cgg>Tgg	p.R357W	NSMAF_ENST00000519858.1_5'UTR|NSMAF_ENST00000427130.2_Missense_Mutation_p.R388W	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	357	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				CTGAGATCCCGGAAGGTTCCT	0.383000													12	115					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84132848	84132848	+	Silent	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr16:84132848C>A	ENST00000343411.3	-	3	726	c.231G>T	c.(229-231)ctG>ctT	p.L77L		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	77					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CACTGCTCTTCAGGGCACTTG	0.348000													47	83					1.6237e-14	1.76613e-14	1	1	0
C8orf33	65265	broad.mit.edu	37	8	146278031	146278031	+	Silent	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr8:146278031G>T	ENST00000331434.6	+	2	180	c.66G>T	c.(64-66)gcG>gcT	p.A22A		NM_023080.2	NP_075568.1	Q9H7E9	CH033_HUMAN	chromosome 8 open reading frame 33	22										endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		CTCCCTGCGCGTCCCGCGGAG	0.687000													88	38					7.63117e-38	9.27711e-38	1	1	0
PPP2R5D	5528	broad.mit.edu	37	6	42975720	42975720	+	Silent	SNP	C	C	G			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr6:42975720C>G	ENST00000485511.1	+	7	953	c.774C>G	c.(772-774)ctC>ctG	p.L258L	PPP2R5D_ENST00000472118.1_Silent_p.L250L|PPP2R5D_ENST00000394110.3_Silent_p.L226L|PPP2R5D_ENST00000461010.1_Silent_p.L152L	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	258					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGGACTTCCTCAAGACCATTT	0.552000													45	94					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176675230	176675230	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr5:176675230G>T	ENST00000439151.2	+	11	4591	c.4546G>T	c.(4546-4548)Gag>Tag	p.E1516*	NSD1_ENST00000354179.4_Nonsense_Mutation_p.E1247*|NSD1_ENST00000361032.4_Nonsense_Mutation_p.E1413*|NSD1_ENST00000347982.4_Nonsense_Mutation_p.E1247*	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1516					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGAGACTGTTGAGGAAGGTGT	0.488000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			22	13					7.45023e-12	7.96403e-12	1	1	0
DZIP1	22873	broad.mit.edu	37	13	96293908	96293908	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:96293908C>A	ENST00000347108.3	-	3	670	c.238G>T	c.(238-240)Gtg>Ttg	p.V80L	DZIP1_ENST00000361396.2_Missense_Mutation_p.V80L|DZIP1_ENST00000466027.1_5'UTR|DZIP1_ENST00000376829.2_Missense_Mutation_p.V80L|DZIP1_ENST00000361156.3_Missense_Mutation_p.V80L			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	80					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GCCCCCGCCACCTTGTCCACG	0.662000													38	70					2.19962e-31	2.62263e-31	1	1	0
AADAC	13	broad.mit.edu	37	3	151545711	151545711	+	Silent	SNP	G	G	C			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr3:151545711G>C	ENST00000232892.6	+	5	1077	c.951G>C	c.(949-951)gtG>gtC	p.V317V	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	317					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TCCTAGATGTGAGGGCAGCCC	0.433000													24	54					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16349201	16349201	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:16349201delC	ENST00000375692.1	+	3	215	c.87delC	c.(85-87)cgfs	p.R30fs	CLCNKA_ENST00000331433.4_Frame_Shift_Del_p.R30fs|CLCNKA_ENST00000420078.1_Frame_Shift_Del_p.R30fs|CLCNKA_ENST00000439316.2_Frame_Shift_Del_p.R30fs|CLCNKA_ENST00000464764.1_3'UTR			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	30					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CCCACATCCGCCGAGCCATCC	0.662													2	4	---	---	---	---					
NDUFS5	4725	broad.mit.edu	37	1	39500131	39500135	+	Frame_Shift_Del	DEL	CACCT	CACCT	-	rs1050978		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr1:39500131_39500135delCACCT	ENST00000372969.3	+	3	371_375	c.284_288delCACCT	c.(283-288)cfs	p.PP95fs	NDUFS5_ENST00000372967.3_Frame_Shift_Del_p.PP95fs	NM_004552.2	NP_004543.1	O43920	NDUS5_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	95					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|large_intestine(2)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.93e-18)		NADH(DB00157)	TACACCCCTCCACCTCACCACATTG	0.502													18	61	---	---	---	---					
ZNF876P	642280	broad.mit.edu	37	4	212236	212236	+	RNA	DEL	A	A	-	rs80061878		TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr4:212236delA	ENST00000356347.3	+	0	172					NR_027481.1																						ctaaaaatacaaaaaaaaaaa	0.493													2	4	---	---	---	---					
CARD11	84433	broad.mit.edu	37	7	2954870	2954873	+	Splice_Site	DEL	CCTT	CCTT	-			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr7:2954870_2954873delCCTT	ENST00000396946.4	-	21	3240_3243	c.2839_splice	c.e21+1	p.946_splice		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	946					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCCCCATGTACCTTCCTGCTTCTC	0.637			Mis		DLBCL								27	54	---	---	---	---					
TAF5	6877	broad.mit.edu	37	10	105127982	105127982	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr10:105127982delC	ENST00000369839.3	+	1	259	c.236delC	c.(235-237)gcfs	p.A79fs	TAF5_ENST00000351396.4_Frame_Shift_Del_p.A79fs	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	79					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		gcgggggcggccccggtgccc	0.756													2	4	---	---	---	---					
PDX1	3651	broad.mit.edu	37	13	28494313	28494313	+	Frame_Shift_Del	DEL	T	T	-			TCGA-P3-A6T6-01A-11D-A34J-08	TCGA-P3-A6T6-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f48dd4fb-5ca5-4cd4-860c-7aedfa65adb9	d1623ca9-854a-4331-a006-88e54166eb6f	g.chr13:28494313delT	ENST00000381033.4	+	1	157	c.38delT	c.(37-39)ctfs	p.L13fs	PDX1-AS1_ENST00000499662.2_RNA	NM_000209.3	NP_000200.1	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	13	Transactivation domain (By similarity).				detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity					all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		GCCACGCAGCTTTACAAGGAC	0.741													2	4	---	---	---	---					
