Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EIF4G2	1982	broad.mit.edu	37	11	10823638	10823638	+	Silent	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:10823638T>C	ENST00000526148.1	-	13	1767	c.1257A>G	c.(1255-1257)caA>caG	p.Q419Q	EIF4G2_ENST00000339995.5_Silent_p.Q419Q|EIF4G2_ENST00000525681.1_Silent_p.Q419Q|EIF4G2_ENST00000396525.2_Silent_p.Q419Q	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	419					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CAAACTGCGATTGTGTGGGAG	0.428000													19	61					0	0	1	0	0
WSB1	26118	broad.mit.edu	37	17	25631813	25631813	+	Silent	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:25631813C>A	ENST00000262394.2	+	4	802	c.486C>A	c.(484-486)ctC>ctA	p.L162L	WSB1_ENST00000579733.1_Silent_p.L16L|WSB1_ENST00000583193.1_Intron|WSB1_ENST00000581185.1_Silent_p.L162L|WSB1_ENST00000348811.2_Silent_p.L16L|WSB1_ENST00000427287.2_Silent_p.L131L	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	162					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TAGGAAAACTCCTCCTTAACT	0.358000													13	32					1.49906e-05	1.52458e-05	1	1	0
ADCY10	55811	broad.mit.edu	37	1	167798634	167798634	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:167798634C>T	ENST00000367848.1	-	26	3842	c.3345G>A	c.(3343-3345)cgG>cgA	p.R1115R	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.R1207R|ADCY10_ENST00000545172.1_Silent_p.R1054R			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1207					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding	p.R1207R(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGACAGTTTGCCGGTAAAGTT	0.423000													5	92					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72425365	72425365	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:72425365G>A	ENST00000333850.3	+	11	1504	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	455					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	ACAGAGTATTGAAATTCTGAA	0.393000													19	49					0	0	1	0	0
STRA8	346673	broad.mit.edu	37	7	134925454	134925454	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:134925454C>T	ENST00000275764.3	+	2	244	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F		NM_182489.1	NP_872295.1	Q7Z7C7	STRA8_HUMAN	stimulated by retinoic acid 8	82					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(1)	16						TCAGTCTGATCTCATAGCCTC	0.612000													17	57					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134107289	134107289	+	Splice_Site	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:134107289G>C	ENST00000220616.4	+	42	7281	c.7239_splice	c.e42-1	p.G2414_splice	TG_ENST00000542445.1_Splice_Site_p.G784_splice|TG_ENST00000377869.1_Splice_Site_p.G2357_splice|SLA_ENST00000517648.1_Intron|SLA_ENST00000338087.5_Intron|SLA_ENST00000395352.3_Intron|SLA_ENST00000524345.1_Intron|TG_ENST00000519543.1_Splice_Site_p.G547_splice|SLA_ENST00000518565.1_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2414					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTCTTCCAGGGAGGCTCCGCA	0.592000													30	131					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139413262	139413262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:139413262C>A	ENST00000277541.6	-	6	955	c.880G>T	c.(880-882)Gag>Tag	p.E294*		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	294					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TCCACATCCTCGGTACAGTAC	0.642000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			36	21					3.09479e-21	3.33178e-21	1	1	0
STRIP2	57464	broad.mit.edu	37	7	129093089	129093089	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:129093089C>T	ENST00000249344.2	+	5	471	c.431C>T	c.(430-432)tCa>tTa	p.S144L	STRIP2_ENST00000435494.2_Missense_Mutation_p.S144L	NM_020704.2	NP_065755.1			striatin interacting protein 2																		GAATGTGATTCAGAGGTCGAT	0.507000													27	58					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28707753	28707753	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:28707753C>T	ENST00000416984.2	-	3	534	c.175G>A	c.(175-177)Gat>Aat	p.D59N	INTS9_ENST00000521777.1_Missense_Mutation_p.D35N|INTS9_ENST00000521022.1_Missense_Mutation_p.D59N|INTS9_ENST00000397363.4_5'UTR	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	59					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		GCATTTCCATCCTTCAGGGAC	0.398000													37	96					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43348459	43348459	+	RNA	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:43348459C>T	ENST00000344686.2	-	0	1892							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GAACTGAGTCCAGGGGTGGCA	0.667000											OREG0024479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30101537	30101537	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:30101537G>A	ENST00000585603.1	+	3	2584	c.282G>A	c.(280-282)caG>caA	p.Q94Q	POP4_ENST00000392279.3_Intron|POP4_ENST00000221770.3_Intron|POP4_ENST00000591824.1_3'UTR			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	94					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding			breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			CAGAGCAGCAGAGGTAACCCG	0.582000											OREG0025393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	13					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153881969	153881969	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:153881969A>G	ENST00000511601.1	+	6	1011	c.823A>G	c.(823-825)Ata>Gta	p.I275V	FHDC1_ENST00000260008.3_Missense_Mutation_p.I275V			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	275	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ATATACAGATATAACAGTTTT	0.308000													3	20					0	0	1	0	0
EIF6	3692	broad.mit.edu	37	20	33868521	33868521	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:33868521G>A	ENST00000374450.3	-	4	569	c.305C>T	c.(304-306)tCa>tTa	p.S102L	EIF6_ENST00000374436.3_Missense_Mutation_p.S102L|EIF6_ENST00000374443.3_Intron|EIF6_ENST00000462894.1_Intron	NM_002212.3	NP_002203.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	102					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCCCAAGGCTGAGAGCCGCTC	0.592000													7	12					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971156	21971156	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:21971156C>G	ENST00000579755.1	-	2	537	c.245G>C	c.(244-246)cGc>cCc	p.R82P	CDKN2A_ENST00000530628.2_Missense_Mutation_p.R82P|CDKN2A_ENST00000446177.1_Missense_Mutation_p.A68P|CDKN2A_ENST00000498124.1_Missense_Mutation_p.A68P|CDKN2A_ENST00000479692.2_Missense_Mutation_p.A17P|CDKN2A_ENST00000498628.2_Missense_Mutation_p.A17P|CDKN2A_ENST00000578845.2_Missense_Mutation_p.A17P|CDKN2A_ENST00000361570.3_Missense_Mutation_p.R123P|CDKN2A_ENST00000304494.5_Missense_Mutation_p.A68P|CDKN2A_ENST00000494262.1_Missense_Mutation_p.A17P|CDKN2A_ENST00000497750.1_Missense_Mutation_p.A17P|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579122.1_Missense_Mutation_p.A68P			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(45)|p.A68T(5)|p.E61fs*49(2)|p.E61fs*50(1)|p.R122fs*49(1)|p.E61_L94del(1)|p.0(1)|p.L64_E69>Q(1)|p.V59fs*45(1)|p.L65fs*38(1)|p.L65fs*77(1)|p.A68fs*3(1)|p.L63fs*75(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TTGGGCTCCGCGCCGTGGAGC	0.706000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	12					0	0	1	0	0
NKX2-5	1482	broad.mit.edu	37	5	172659656	172659656	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:172659656G>A	ENST00000329198.4	-	2	1164	c.891C>T	c.(889-891)gtC>gtT	p.V297V		NM_001166175.1|NM_001166176.1|NM_004387.3	NP_001159647.1|NP_001159648.1|NP_004378.1	P52952	NKX25_HUMAN	NK2 homeobox 5	297					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)	12	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TCAAGTCCCCGACGCCGAAGT	0.667000													10	24					0	0	1	0	0
CCNY	219771	broad.mit.edu	37	10	35814905	35814905	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:35814905A>T	ENST00000374704.4	+	5	559	c.379A>T	c.(379-381)Ata>Tta	p.I127L	CCNY_ENST00000265375.9_Missense_Mutation_p.I73L|CCNY_ENST00000492478.1_3'UTR|CCNY_ENST00000374706.1_Missense_Mutation_p.I73L|CCNY_ENST00000339497.5_Missense_Mutation_p.I102L	NM_145012.4	NP_659449.3	Q8ND76	CCNY_HUMAN	cyclin Y	127					cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	8						CGCTCTTGCAATATATTATCA	0.348000													19	30					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	49					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26031895	26031895	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:26031895G>A	ENST00000244661.2	-	1	393	c.394C>T	c.(394-396)Cgc>Tgc	p.R132C		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	132					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CTTTCTCCGCGAATGCGGCGA	0.478000													17	43					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000348295.3_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	56					0	0	1	0	0
GDPD3	79153	broad.mit.edu	37	16	30123725	30123725	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr16:30123725C>G	ENST00000406256.3	-	5	762	c.385G>C	c.(385-387)Gac>Cac	p.D129H		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	129	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						ATGCGCCGGTCTGACCCGTGA	0.602000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	62					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233802462	233802462	+	Silent	SNP	C	C	T	rs143943031		TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:233802462C>T	ENST00000366621.3	+	2	645	c.477C>T	c.(475-477)caC>caT	p.H159H	KCNK1_ENST00000366620.1_Silent_p.H43H|KCNK1_ENST00000472190.1_3'UTR	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	159						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCACCGTGCACGTCACCCGCA	0.592000													13	38					0	0	1	0	0
PREPL	9581	broad.mit.edu	37	2	44548994	44548994	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:44548994T>C	ENST00000541738.1	-	13	2185	c.1799A>G	c.(1798-1800)aAt>aGt	p.N600S	PREPL_ENST00000409272.1_Missense_Mutation_p.N689S|PREPL_ENST00000378520.3_Missense_Mutation_p.N623S|PREPL_ENST00000260648.6_Missense_Mutation_p.N689S|PREPL_ENST00000410081.1_Missense_Mutation_p.N689S|PREPL_ENST00000409936.1_Missense_Mutation_p.N689S|PREPL_ENST00000409957.1_Missense_Mutation_p.N600S|PREPL_ENST00000409411.1_Missense_Mutation_p.N600S|PREPL_ENST00000378511.3_Missense_Mutation_p.N627S	NM_001171617.1	NP_001165088.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like	689					proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AATTACATGATTGCCTCCAGG	0.383000													12	34					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139740915	139740915	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:139740915C>G	ENST00000436881.1	+	1	2049	c.2049C>G	c.(2047-2049)ttC>ttG	p.F683L		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	683										endometrium(2)|large_intestine(1)|lung(6)	9						GCCTCTACTTCAAGTCCTGCC	0.677000													32	56					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46307421	46307421	+	Splice_Site	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:46307421G>T	ENST00000359930.4	-	8	2043	c.1193_splice	c.e8+1	p.R398_splice	CTD-2653D5.1_ENST00000526566.2_RNA|SULF2_ENST00000484875.1_Splice_Site_p.R398_splice|SULF2_ENST00000361612.4_Splice_Site_p.R398_splice|SULF2_ENST00000467815.1_Splice_Site_p.R398_splice	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	398					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CGTCCTCACCGATTCACCGGC	0.622000													67	194					1.35621e-51	1.47334e-51	1	1	0
TRAV29DV5	28653	broad.mit.edu	37	14	22631651	22631651	+	RNA	SNP	T	T	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr14:22631651T>G	ENST00000390458.3	+	0	354																											CCATTAAGGATAAAAATGAAG	0.403000											OREG0022575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	18					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28840936	28840936	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr13:28840936A>T	ENST00000399613.1	+	9	959	c.896A>T	c.(895-897)aAt>aTt	p.N299I	PAN3_ENST00000282391.5_Missense_Mutation_p.N187I|PAN3_ENST00000380958.3_Missense_Mutation_p.N499I			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	499	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AAATCAAGTAATTTTGGATAT	0.403000													19	38					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109730882	109730882	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:109730882G>C	ENST00000369939.3	+	9	1308	c.1125G>C	c.(1123-1125)gtG>gtC	p.V375V	KIAA1324_ENST00000529753.1_Silent_p.V288V|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	375					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCTCTGGTGTGAAGACCCACT	0.537000													33	117					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86813226	86813226	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:86813226G>A	ENST00000441037.2	+	13	1872	c.1777G>A	c.(1777-1779)Ggt>Agt	p.G593S	AGBL1_ENST00000389298.3_Missense_Mutation_p.G324S|AGBL1_ENST00000421325.2_Missense_Mutation_p.G593S	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	593					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CAAAGTGAGCGGTATGCAGGC	0.498000													6	14					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50734082	50734082	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:50734082G>A	ENST00000442544.2	+	11	2372	c.1756G>A	c.(1756-1758)Gaa>Aaa	p.E586K	DCC_ENST00000581580.1_Missense_Mutation_p.E241K|DCC_ENST00000412726.1_Missense_Mutation_p.E434K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	586	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTATAAACTGGAAGGCCTGAA	0.378000													18	38					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112227669	112227669	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:112227669C>A	ENST00000546840.2	+	6	473	c.473C>A	c.(472-474)tCc>tAc	p.S158Y	ALDH2_ENST00000261733.2_Silent_p.I161I|ALDH2_ENST00000416293.3_Silent_p.I114I																							GGAAAACCATCCCCATTGACG	0.522000													10	32					4.68919e-08	4.87268e-08	1	1	0
CAMKV	79012	broad.mit.edu	37	3	49899497	49899497	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:49899497C>T	ENST00000477224.1	-	3	686	c.208G>A	c.(208-210)Gag>Aag	p.E70K	CAMKV_ENST00000463537.1_Missense_Mutation_p.E70K|CAMKV_ENST00000296471.7_Missense_Mutation_p.E70K|CAMKV_ENST00000498324.1_5'UTR|CAMKV_ENST00000488336.1_Missense_Mutation_p.E70K|CAMKV_ENST00000467248.1_5'UTR|CAMKV_ENST00000466940.1_Missense_Mutation_p.E70K			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	70	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATGCCTATCTCGTTCTTGGCA	0.597000													15	8					0	0	1	0	0
TOE1	114034	broad.mit.edu	37	1	45808314	45808314	+	Splice_Site	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:45808314T>C	ENST00000372090.5	+	6	1334	c.752_splice	c.e6+1	p.C251_splice	TOE1_ENST00000495703.1_3'UTR|TOE1_ENST00000539779.1_Splice_Site_p.C171_splice	NM_025077.3	NP_079353.3	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	251						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	11	Acute lymphoblastic leukemia(166;0.155)					CTTCCGGAAATGGTGAGGAAA	0.468000													47	138					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201437151	201437151	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:201437151G>T	ENST00000357799.4	+	7	2180	c.2082G>T	c.(2080-2082)caG>caT	p.Q694H		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	694					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TGCAAAAGCAGATCACCAATA	0.363000													14	40					1.52009e-12	1.60045e-12	1	1	0
REG3A	5068	broad.mit.edu	37	2	79386510	79386510	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:79386510G>T	ENST00000393878.1	-	1	276	c.22C>A	c.(22-24)Ccc>Acc	p.P8T	REG3A_ENST00000409839.3_Missense_Mutation_p.P8T|AC011754.1_ENST00000415201.1_RNA|REG3A_ENST00000305165.2_Missense_Mutation_p.P8T	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	8					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						GATACACTGGGCAGGGCCATG	0.532000													11	42					2.27111e-07	2.32959e-07	1	1	0
ZNF835	90485	broad.mit.edu	37	19	57175283	57175283	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:57175283G>A	ENST00000537055.2	-	2	1515	c.1284C>T	c.(1282-1284)agC>agT	p.S428S		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.S450R(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AGGAGCCCTGGCTGAAAGCTT	0.672000													12	35					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161029180	161029180	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:161029180G>A	ENST00000283249.2	-	6	1058	c.821C>T	c.(820-822)tCt>tTt	p.S274F	ITGB6_ENST00000409872.1_Missense_Mutation_p.S274F|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000428609.2_Missense_Mutation_p.S232F|ITGB6_ENST00000409967.2_Missense_Mutation_p.S274F			P18564	ITB6_HUMAN	integrin, beta 6	274	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCCAAAATGAGAATCAGCATC	0.453000													37	93					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141317106	141317106	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:141317106C>T	ENST00000325617.5	-	10	1456	c.1016G>A	c.(1015-1017)gGa>gAa	p.G339E	CLGN_ENST00000537281.1_Missense_Mutation_p.G339E|CLGN_ENST00000414773.1_Missense_Mutation_p.G339E	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	339					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					CTCCCATTCTCCATCCGTGTC	0.398000													13	41					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922663	5922663	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:5922663C>G	ENST00000399933.3	-	8	3332	c.3333G>C	c.(3331-3333)gtG>gtC	p.V1111V	KIAA2026_ENST00000381461.2_Silent_p.V1081V	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1111										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TATGCTGAATCACAAAATTCT	0.378000													20	52					0	0	1	0	0
MEX3C	51320	broad.mit.edu	37	18	48723007	48723007	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:48723007C>G	ENST00000592416.1	-	1	122	c.123G>C	c.(121-123)aaG>aaC	p.K41N	MEX3C_ENST00000591040.1_Intron			Q5U5Q3	MEX3C_HUMAN	mex-3 RNA binding family member C	228						cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|skin(1)	17		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		TGTTGACGCTCTTTCTCCGGA	0.731000													4	7					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17796915	17796915	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:17796915C>T	ENST00000378814.5	-	23	2926	c.2927G>A	c.(2926-2928)aGa>aAa	p.R976K	KIF13A_ENST00000378843.2_Missense_Mutation_p.R976K|KIF13A_ENST00000259711.6_Missense_Mutation_p.R976K|KIF13A_ENST00000378826.2_Missense_Mutation_p.R976K|KIF13A_ENST00000378816.5_Missense_Mutation_p.R976K	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	976					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			ATGCAGTGTTCTTGTCTTAGC	0.498000													39	101					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879176	144879176	+	Missense_Mutation	SNP	C	C	T	rs145464352		TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:144879176C>T	ENST00000369359.4	-	30	4720	c.4682G>A	c.(4681-4683)gGg>gAg	p.G1561E	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.G1425E|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.G1381E|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.G1561E|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.G1425E			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1425	NBPF.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTAGAAAGCCCCAGTGCCATC	0.552000			T	PDGFRB	MPD								7	89					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101266313	101266313	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:101266313C>T	ENST00000223167.4	-	4	490	c.313G>A	c.(313-315)Gac>Aac	p.D105N		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	105	EF-hand 1.					mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						TCCTCTTTGTCGATGAAGCCA	0.627000													11	39					0	0	1	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52034950	52034950	+	RNA	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr13:52034950G>A	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000596180.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000593709.1_RNA																							CAAGACAGAAGAGAATTTCTC	0.408000													3	21					0	0	1	0	0
AWAT2	158835	broad.mit.edu	37	X	69264203	69264203	+	Splice_Site	SNP	T	T	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:69264203T>A	ENST00000276101.3	-	2	200	c.196_splice	c.e2+1	p.R65_splice		NM_001002254.1	NP_001002254.1	Q6E213	AWAT2_HUMAN	acyl-CoA wax alcohol acyltransferase 2	65						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			endometrium(3)|large_intestine(3)|lung(2)|ovary(1)	9						GATGCTTACCTCGCTGAGGGG	0.532000													16	6					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973715	46973715	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:46973715C>T	ENST00000313683.10	-	2	883	c.578G>A	c.(577-579)gGg>gAg	p.G193E	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.G193E	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	193										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CACCTTCCTCCCTGCTGCTAA	0.592000													21	82					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62294399	62294399	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:62294399T>C	ENST00000378024.4	-	5	7764	c.7490A>G	c.(7489-7491)aAt>aGt	p.N2497S	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2497					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ATCGGGGGCATTTACATCAAC	0.507000													53	122					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	121097619	121097619	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:121097619C>T	ENST00000273666.6	+	22	2576	c.2305C>T	c.(2305-2307)Cgt>Tgt	p.R769C	STXBP5L_ENST00000492541.1_Missense_Mutation_p.R769C|STXBP5L_ENST00000497029.1_Intron|STXBP5L_ENST00000471454.1_Missense_Mutation_p.R745C|STXBP5L_ENST00000472879.1_Missense_Mutation_p.R745C	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	769					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TTCTGGAAAACGTCTTTCTAG	0.463000													8	15					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95169470	95169470	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:95169470C>T	ENST00000371501.4	-	6	582	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K	MYOF_ENST00000359263.4_Missense_Mutation_p.E154K|MYOF_ENST00000358334.5_Missense_Mutation_p.E154K|MYOF_ENST00000371502.4_Missense_Mutation_p.E154K|MYOF_ENST00000371489.1_Missense_Mutation_p.E154K			Q9NZM1	MYOF_HUMAN	myoferlin	154					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AACCTGTCTTCATCACCTTCA	0.517000													80	237					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725567	32725567	+	Missense_Mutation	SNP	C	C	T	rs114234640	byFrequency	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:32725567C>T	ENST00000435145.2	-	4	801	c.740G>A	c.(739-741)cGt>cAt	p.R247H	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.R247H			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						ACCCCTGTGACGGATGATAAG	0.552000													5	16					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51612982	51612982	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:51612982G>A	ENST00000371117.3	-	58	9707	c.9432C>T	c.(9430-9432)atC>atT	p.I3144I	PKHD1_ENST00000340994.4_Silent_p.I3144I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3144					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGAAGCCAGAGATTCTGGTAC	0.433000													63	144					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36686199	36686199	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr13:36686199C>T	ENST00000255448.4	-	3	741	c.530G>A	c.(529-531)cGa>cAa	p.R177Q	DCLK1_ENST00000360631.3_Missense_Mutation_p.R177Q|DCLK1_ENST00000379892.4_Missense_Mutation_p.R177Q	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	177					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTTATTCTCTCGCACCTCTGA	0.532000													29	69					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66112497	66112497	+	Splice_Site	SNP	T	T	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:66112497T>A	ENST00000503581.1	-	7	1595	c.1056_splice	c.e7-1	p.D353_splice	EYS_ENST00000370616.2_Splice_Site_p.D353_splice|EYS_ENST00000370618.3_Splice_Site_p.D353_splice|EYS_ENST00000370621.3_Splice_Site_p.D353_splice|EYS_ENST00000342421.5_Splice_Site_p.D353_splice|EYS_ENST00000393380.2_Splice_Site_p.D353_splice	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	353	EGF-like 4.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GCACATAACATCCTAGGAAAG	0.303000													10	22					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212118259	212118259	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:212118259T>C	ENST00000366994.3	-	19	2572	c.2468A>G	c.(2467-2469)aAt>aGt	p.N823S	INTS7_ENST00000366993.3_Missense_Mutation_p.N809S|INTS7_ENST00000366992.3_Missense_Mutation_p.N803S|INTS7_ENST00000440600.2_Missense_Mutation_p.N774S|INTS7_ENST00000469606.1_5'UTR	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	823					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGCTGGTTATTCTGGACAGC	0.502000													18	40					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23523379	23523379	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr14:23523379C>T	ENST00000397359.3	-	6	1202	c.943G>A	c.(943-945)Ggt>Agt	p.G315S	CDH24_ENST00000487137.2_Missense_Mutation_p.G315S|CDH24_ENST00000267383.5_Missense_Mutation_p.G315S|CDH24_ENST00000554034.1_Missense_Mutation_p.G315S	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	315	Cadherin 3.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCGTCTCGACCCTGCAAGTCT	0.597000													42	93					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47863722	47863722	+	Splice_Site	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr21:47863722G>C	ENST00000359568.5	+	45	9807		c.e45-1		PCNT_ENST00000480896.1_Splice_Site	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin						cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TTCTGGGGAAGGGCCCCGAGC	0.507000													16	74					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540475	187540475	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:187540475A>T	ENST00000441802.2	-	10	7474	c.7265T>A	c.(7264-7266)aTa>aAa	p.I2422K		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2422	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAACTTGTCTATGTCTGAACT	0.448000										HNSCC(5;0.00058)			15	37					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31581693	31581693	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr14:31581693G>T	ENST00000399332.1	-	35	6695	c.6207C>A	c.(6205-6207)agC>agA	p.S2069R	HECTD1_ENST00000553700.1_Missense_Mutation_p.S2069R	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2069	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AAGGACATTTGCTGGTTAATT	0.388000													14	23					6.72482e-11	7.04927e-11	1	1	0
STX11	8676	broad.mit.edu	37	6	144508214	144508214	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:144508214G>T	ENST00000367568.4	+	2	633	c.450G>T	c.(448-450)gaG>gaT	p.E150D		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	150					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		ACCAGGCCGAGATGAAGCAGC	0.637000									Familial Hemophagocytic Lymphohistiocytosis				15	32					1.15088e-07	1.1856e-07	1	1	0
ZNF91	7644	broad.mit.edu	37	19	23543545	23543545	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:23543545C>T	ENST00000300619.7	-	4	2441	c.2236G>A	c.(2236-2238)Gaa>Aaa	p.E746K	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.E714K	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	746						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGCCACATTCTTCACACTTG	0.338000													8	24					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135187212	135187212	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:135187212C>G	ENST00000372169.2	-	11	5488	c.5306G>C	c.(5305-5307)aGa>aCa	p.R1769T	SETX_ENST00000224140.5_Missense_Mutation_p.R1769T|SETX_ENST00000393220.1_Missense_Mutation_p.R1769T			Q7Z333	SETX_HUMAN	senataxin	1769					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GAAATTCTCTCTATTTGGAGA	0.343000													14	18					0	0	1	0	0
FAM46A	55603	broad.mit.edu	37	6	82461310	82461310	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:82461310G>C	ENST00000369754.3	-	2	918	c.606C>G	c.(604-606)ctC>ctG	p.L202L	FAM46A_ENST00000320172.6_Silent_p.L183L|FAM46A_ENST00000369756.3_Silent_p.L264L			Q96IP4	FA46A_HUMAN	family with sequence similarity 46, member A	183										endometrium(2)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	12		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		GTGTTACCTTGAGCGTGAGTG	0.577000													15	44					0	0	1	0	0
CDC37L1	55664	broad.mit.edu	37	9	4701900	4701900	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:4701900G>C	ENST00000381854.3	+	6	986	c.784G>C	c.(784-786)Gaa>Caa	p.E262Q	CDC37L1_ENST00000381858.1_Missense_Mutation_p.E262Q	NM_017913.2	NP_060383.2	Q7L3B6	CD37L_HUMAN	cell division cycle 37-like 1	262	Self-association and interaction with Hsp90.					cytoplasm				breast(1)|kidney(1)|lung(2)	4	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		ATTCAAAAATGAACTTGAAGC	0.333000													8	25					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	55					0	0	1	0	0
IPP	3652	broad.mit.edu	37	1	46206694	46206694	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:46206694G>C	ENST00000396478.3	-	3	705	c.603C>G	c.(601-603)ttC>ttG	p.F201L		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	201						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TTGCAGCTAAGAAGACCTGGT	0.413000													19	56					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13251295	13251295	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:13251295G>C	ENST00000378714.3	+	20	2738	c.2610G>C	c.(2608-2610)ctG>ctC	p.L870L	MCM10_ENST00000484800.2_Silent_p.L871L|MCM10_ENST00000378694.1_3'UTR	NM_018518.4|NM_182751.2	NP_060988.3|NP_877428.1	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	871					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						CTAAATTTCTGAACAGCCTTA	0.398000													7	37					0	0	1	0	0
ABHD1	84696	broad.mit.edu	37	2	27351467	27351467	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:27351467G>C	ENST00000316470.4	+	2	387	c.273G>C	c.(271-273)caG>caC	p.Q91H		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	91						integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTTTATCAGAGGTAAGAAG	0.468000													26	50					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17434770	17434770	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:17434770C>G	ENST00000541323.1	+	2	454	c.9C>G	c.(7-9)gtC>gtG	p.V3V	PDGFRL_ENST00000251630.6_Silent_p.V3V|PDGFRL_ENST00000398074.3_Silent_p.V3V	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	3						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		AGATGAAGGTCTGGCTGCTGC	0.711000											OREG0018579	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44248549	44248549	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:44248549G>A	ENST00000262419.6	-	2	1431	c.961C>T	c.(961-963)Ctg>Ttg	p.L321L	KANSL1_ENST00000572904.1_Silent_p.L321L|KANSL1_ENST00000432791.1_Silent_p.L321L|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000575318.1_Silent_p.L321L|KANSL1_ENST00000574590.1_Silent_p.L321L	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	321						MLL1 complex	protein binding										AATCCACCCAGCTGATGTTGT	0.512000													20	72					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5784161	5784161	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:5784161C>T	ENST00000328090.5	+	14	3054	c.2429C>T	c.(2428-2430)tCt>tTt	p.S810F	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	810																	ATCATACGATCTTCCCGAAAG	0.408000													10	31					0	0	1	0	0
NKIRAS1	28512	broad.mit.edu	37	3	23942311	23942311	+	Silent	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:23942311T>C	ENST00000443659.2	-	3	1101	c.324A>G	c.(322-324)aaA>aaG	p.K108K	NKIRAS1_ENST00000437230.1_Silent_p.K108K|NKIRAS1_ENST00000415901.2_Silent_p.K108K|NKIRAS1_ENST00000421515.2_Silent_p.K108K|NKIRAS1_ENST00000416026.2_Silent_p.K108K|NKIRAS1_ENST00000388759.3_Silent_p.K108K|NKIRAS1_ENST00000412028.1_Silent_p.K108K|NKIRAS1_ENST00000425478.2_Silent_p.K108K			Q9NYS0	KBRS1_HUMAN	NFKB inhibitor interacting Ras-like 1	108					I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	7						CTTTTTTGTCTTTGAACTTAT	0.323000													22	11					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70004271	70004271	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:70004271C>G	ENST00000361484.3	-	1	671	c.348G>C	c.(346-348)gaG>gaC	p.E116D		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	116						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GCAGGCTCAGCTCACTGGGGA	0.567000													18	55					0	0	1	0	0
CLDN5	7122	broad.mit.edu	37	22	19511491	19511491	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr22:19511491G>A	ENST00000406028.1	-	2	1603	c.543C>T	c.(541-543)ttC>ttT	p.F181F	CLDN5_ENST00000403084.1_Silent_p.F181F|CLDN5_ENST00000413119.2_Silent_p.F181F			O00501	CLD5_HUMAN	claudin 5	96					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			liver(1)|lung(2)|prostate(1)	4	Colorectal(54;0.0993)					CCAGGGTCACGAAGAGCGCAA	0.711000													3	5					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35045669	35045669	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:35045669C>A	ENST00000312292.5	+	2	3090	c.3043C>A	c.(3043-3045)Ccc>Acc	p.P1015T	C9orf131_ENST00000421362.2_Missense_Mutation_p.P967T|C9orf131_ENST00000354479.5_Missense_Mutation_p.P942T	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	1015										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCTTCGGGTCCCCAGGATCA	0.577000													26	61					4.72057e-08	4.88406e-08	1	1	0
CBWD1	55871	broad.mit.edu	37	9	163990	163990	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:163990T>C	ENST00000377447.3	-	5	533	c.478A>G	c.(478-480)Att>Gtt	p.I160V	CBWD1_ENST00000356521.4_Missense_Mutation_p.I160V|CBWD1_ENST00000377400.4_Missense_Mutation_p.I160V|CBWD1_ENST00000382447.4_Missense_Mutation_p.I160V|CBWD1_ENST00000314367.10_Missense_Mutation_p.I124V|CBWD1_ENST00000431099.2_Missense_Mutation_p.I124V			Q9BRT8	CBWD1_HUMAN	COBW domain containing 1	160							ATP binding|protein binding			kidney(1)|lung(2)|ovary(1)|skin(1)	5	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		TCAAGATAAATATCACTCCCT	0.313000													42	106					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32217648	32217648	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:32217648G>C	ENST00000346541.3	+	9	1720	c.1183G>C	c.(1183-1185)Gag>Cag	p.E395Q	CBFA2T2_ENST00000342704.5_Missense_Mutation_p.E386Q|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.E366Q|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.E395Q|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.E405Q	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	395						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						TGAAAACACAGAGCTGAGGAA	0.522000													12	40					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323347	15323347	+	RNA	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:15323347T>C	ENST00000455308.2	-	0	501					NR_027417.1																						CCAATAAAAGTGGTGTGTGGC	0.303000													3	5					0	0	1	0	0
YY2	404281	broad.mit.edu	37	X	21875100	21875100	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:21875100G>A	ENST00000429584.2	+	1	996	c.498G>A	c.(496-498)acG>acA	p.T166T	MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000365779.2_Intron|MBTPS2_ENST00000379484.5_Intron	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						GCCTGGGCACGAGGAAGTGGG	0.587000													35	57					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22926026	22926026	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:22926026C>T	ENST00000313077.7	+	3	293	c.168C>T	c.(166-168)atC>atT	p.I56I	CYFIP1_ENST00000560848.1_Silent_p.I56I	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	56					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TTACTGGCATCGCAAGATACA	0.453000													19	48					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98649936	98649936	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:98649936G>C	ENST00000361125.1	-	7	932	c.613C>G	c.(613-615)Caa>Gaa	p.Q205E	SMURF1_ENST00000361368.2_Missense_Mutation_p.Q205E|SMURF1_ENST00000480055.1_5'UTR	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	205					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			TGAAGTCTTTGATCTTGACTT	0.592000													27	68					0	0	1	0	0
ERMP1	79956	broad.mit.edu	37	9	5787438	5787438	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:5787438C>G	ENST00000339450.5	-	14	2631	c.2542G>C	c.(2542-2544)Gaa>Caa	p.E848Q	ERMP1_ENST00000543230.1_3'UTR|ERMP1_ENST00000381506.3_3'UTR|ERMP1_ENST00000214893.5_5'UTR	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	848					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		ACCTGCACTTCTATCCAGAAC	0.473000													22	35					0	0	1	0	0
SOGA1	140710	broad.mit.edu	37	20	35444093	35444093	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:35444093G>A	ENST00000237536.4	-	5	2093	c.1752C>T	c.(1750-1752)agC>agT	p.S584S	SOGA1_ENST00000456801.2_Silent_p.S187S|SOGA1_ENST00000357779.3_Silent_p.S346S|SOGA1_ENST00000279034.5_Silent_p.S346S	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	346										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						TGACCTTGCCGCTGAGCTCGC	0.637000													3	10					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25327844	25327844	+	RNA	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:25327844C>T	ENST00000546682.1	+	0	180				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGGGCTTCTTCAGGTGCTGGT	0.483000													9	14					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90409883	90409883	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:90409883G>A	ENST00000369393.3	-	57	8884	c.8769C>T	c.(8767-8769)caC>caT	p.H2923H	MDN1_ENST00000428876.1_Silent_p.H2923H			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2923					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCTGGTGAGGTGGATTACGG	0.478000													17	52					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247202158	247202158	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:247202158C>G	ENST00000366503.2	-	3	303	c.145G>C	c.(145-147)Gac>Cac	p.D49H		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ATATTCTGGTCTTCTGATTTG	0.343000													11	26					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191937885	191937885	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:191937885G>A	ENST00000392320.2	-	5	718	c.404C>T	c.(403-405)tCa>tTa	p.S135L	STAT4_ENST00000358470.4_Missense_Mutation_p.S135L	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	135					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TTCTGAAACTGAAGAACTTTG	0.388000													28	98					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76349813	76349813	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:76349813C>T	ENST00000312916.7	+	10	1873	c.1491C>T	c.(1489-1491)taC>taT	p.Y497Y		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	497					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		GTGACCCTTACGTACTTGAGC	0.403000													24	51					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43127881	43127881	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:43127881G>A	ENST00000359467.3	-	3	130	c.16C>T	c.(16-18)Cag>Tag	p.Q6*	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	6						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TGGAACTTCTGATCTACCTGA	0.418000													5	31					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455565	84455565	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr13:84455565C>G	ENST00000377084.2	-	1	963	c.78G>C	c.(76-78)gaG>gaC	p.E26D		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	26	LRRNT.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AACAGATCTTCTCTTTGCAAA	0.478000													31	67					0	0	1	0	0
HOXD4	3233	broad.mit.edu	37	2	177017499	177017499	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:177017499G>C	ENST00000306324.3	+	2	1009	c.597G>C	c.(595-597)aaG>aaC	p.K199N	HOXD3_ENST00000468418.3_5'UTR	NM_014621.2	NP_055436.2	P09016	HXD4_HUMAN	homeobox D4	199						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GCCAGATCAAGATCTGGTTCC	0.478000													14	61					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323340	15323340	+	RNA	SNP	A	A	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:15323340A>G	ENST00000455308.2	-	0	508					NR_027417.1																						CTTATGGCCAATAAAAGTGGT	0.299000													3	5					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124335581	124335581	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:124335581C>T	ENST00000409039.3	+	34	5920	c.5895C>T	c.(5893-5895)atC>atT	p.I1965I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1965	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCAGCAGATCTGTGAGATCA	0.647000													8	38					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	79639112	79639112	+	Splice_Site	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:79639112C>G	ENST00000464233.1	-	2	64		c.e2-1			NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AATGTGTTATCTGGGGAGATT	0.333000													25	21					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796462	62796462	+	RNA	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:62796462T>C	ENST00000582986.1	-	0	1458					NR_024386.1																						CATCTTCTCATTGTTCCTGAT	0.532000													5	15					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35580468	35580468	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:35580468G>C	ENST00000353139.5	-	28	4010	c.3529C>G	c.(3529-3531)Cac>Gac	p.H1177D	ACACA_ENST00000394406.2_Missense_Mutation_p.H1140D|ACACA_ENST00000360679.3_Missense_Mutation_p.H1082D|ACACA_ENST00000335166.5_Missense_Mutation_p.H1062D	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1140					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGTTGCTGTGATAGAAGAAG	0.388000													22	72					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40854064	40854064	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:40854064G>C	ENST00000255224.3	-	2	698	c.330C>G	c.(328-330)ctC>ctG	p.L110L	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Silent_p.L92L	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	110						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TGCCAGGTTTGAGGTTGGTTT	0.413000													18	62					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8944093	8944093	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:8944093G>C	ENST00000264926.2	-	10	1255	c.1139C>G	c.(1138-1140)tCt>tGt	p.S380C		NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	380					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CTTTTCTGTAGATTCATCTTC	0.299000								Rad6 pathway					28	23					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262180	140262180	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:140262180C>T	ENST00000289272.2	+	1	327	c.327C>T	c.(325-327)atC>atT	p.I109I	PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.I109I|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGGTGATCGTGGACAGGC	0.522000													60	123					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725559	32725559	+	Missense_Mutation	SNP	C	C	T	rs113761247	byFrequency	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:32725559C>T	ENST00000435145.2	-	4	809	c.748G>A	c.(748-750)Ggt>Agt	p.G250S	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.G250S			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CCTTTCTGACCCCTGTGACGG	0.552000													3	15					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	rs67389650		TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:7577127C>T	ENST00000420246.2	-	8	943	c.811G>A	c.(811-813)Gag>Aag	p.E271K	TP53_ENST00000359597.4_Missense_Mutation_p.E271K|TP53_ENST00000269305.4_Missense_Mutation_p.E271K|TP53_ENST00000445888.2_Missense_Mutation_p.E271K|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.E271K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	271	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> Q (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(28)|p.E271*(18)|p.0?(8)|p.E271Q(5)|p.?(2)|p.G266_E271delGRNSFE(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.E271P(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.E271del(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.E271fs*34(1)|p.E271fs*35(1)|p.E271_R273delEVR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	10					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6103627	6103627	+	Silent	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:6103627C>A	ENST00000261405.5	-	36	6464	c.6210G>T	c.(6208-6210)ctG>ctT	p.L2070L		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2070	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGCTGAGCTGCAGTTGGAACT	0.428000													38	85					2.24893e-16	2.38887e-16	1	1	0
ZFP2	80108	broad.mit.edu	37	5	178359177	178359177	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:178359177A>G	ENST00000361362.2	+	5	1393	c.863A>G	c.(862-864)cAt>cGt	p.H288R	ZFP2_ENST00000520301.1_Missense_Mutation_p.H288R|ZFP2_ENST00000503510.2_Missense_Mutation_p.H288R|ZFP2_ENST00000523286.1_Missense_Mutation_p.H288R	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		CTTACCCTACATCAGCGAAAT	0.378000													19	69					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112471054	112471054	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:112471054C>G	ENST00000261745.4	-	23	3027	c.2779G>C	c.(2779-2781)Gac>Cac	p.D927H		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	927						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						AGAGAAGTGTCTTCTAAAATA	0.378000													20	40					0	0	1	0	0
COMTD1	118881	broad.mit.edu	37	10	76995480	76995480	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:76995480C>T	ENST00000372538.3	-	2	198	c.116G>A	c.(115-117)cGa>cAa	p.R39Q	COMTD1_ENST00000460899.1_5'UTR	NM_144589.2	NP_653190.2	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing 1	39						integral to membrane	O-methyltransferase activity			central_nervous_system(1)|large_intestine(1)|lung(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					TCGCCGGCCTCGCCATGGGGG	0.721000													4	6					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137206631	137206631	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:137206631C>G	ENST00000239926.4	+	2	665	c.291C>G	c.(289-291)ctC>ctG	p.L97L	RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000421631.2_Intron|MYOT_ENST00000509812.1_Intron|MYOT_ENST00000515645.1_5'UTR	NM_006790.2	NP_006781.1	Q9UBF9	MYOTI_HUMAN	myotilin	97	Necessary for interaction with ACTN1.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CCAGCTTCCTCAGCTCCATAT	0.478000													11	45					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107824918	107824918	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:107824918G>A	ENST00000317357.5	+	2	813	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	52							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TGATAAGGTTGAATTAAAAGA	0.393000													24	51					0	0	1	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180948	142180948	+	RNA	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:142180948C>G	ENST00000390368.2	-	0	68																											GGCCGATGCTCATGGCAGATG	0.567000													8	31					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44419217	44419217	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:44419217T>C	ENST00000269973.5	-	10	1461	c.371A>G	c.(370-372)aAt>aGt	p.N124S	ZNF45_ENST00000589703.1_Missense_Mutation_p.N124S|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	124					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						TCTTTGAATATTTACCACAGA	0.403000													12	34					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113171109	113171109	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:113171109C>G	ENST00000401783.2	-	38	7107	c.6771G>C	c.(6769-6771)ctG>ctC	p.L2257L	SVEP1_ENST00000374469.1_Silent_p.L2234L|SVEP1_ENST00000297826.5_Silent_p.L183L	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2257	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GAACACACATCAGAGGGGATT	0.483000													49	159					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9484911	9484911	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:9484911G>C	ENST00000281419.3	+	11	1345	c.1005G>C	c.(1003-1005)ctG>ctC	p.L335L	ASAP2_ENST00000315273.4_Silent_p.L335L	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	335	PH.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						ATGGTTTTCTGACCATATCCC	0.408000													10	24					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71949087	71949087	+	Splice_Site	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:71949087C>A	ENST00000298229.2	+	27	3758	c.3552_splice	c.e27-1	p.A1185_splice	INPPL1_ENST00000538751.1_Splice_Site_p.A943_splice|INPPL1_ENST00000541756.1_Splice_Site_p.A943_splice	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1185					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding	p.A1185D(2)		breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TTTCCTTAGGCTCCGTGCCTG	0.657000											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					1	1	1	1	0
VPS13A	23230	broad.mit.edu	37	9	79895113	79895113	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:79895113G>C	ENST00000360280.3	+	27	3123	c.2863G>C	c.(2863-2865)Gat>Cat	p.D955H	VPS13A_ENST00000376636.3_Missense_Mutation_p.D955H|VPS13A_ENST00000357409.5_Missense_Mutation_p.D955H|VPS13A_ENST00000376634.4_Missense_Mutation_p.D955H|VPS13A_ENST00000423463.2_3'UTR	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	955					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TACAACCCTGGATAACACAAT	0.303000													11	32					0	0	1	0	0
BSX	390259	broad.mit.edu	37	11	122848402	122848402	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:122848402G>A	ENST00000343035.2	-	3	705	c.657C>T	c.(655-657)gaC>gaT	p.D219D		NM_001098169.1	NP_001091639.1	Q3C1V8	BSH_HUMAN	brain-specific homeobox	219										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	10		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CGTCTCCAATGTCCACCTCGT	0.736000													18	40					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982199	7982199	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:7982199C>T	ENST00000328600.2	-	2	1121	c.960G>A	c.(958-960)agG>agA	p.R320R		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	320	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTACCTCGCCCTCTCCTCCT	0.517000													26	62					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29761676	29761676	+	RNA	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:29761676C>G	ENST00000457107.1	+	0	902																											gagagggtttcatattcaaga	0.493000													6	23					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91737898	91737898	+	Silent	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:91737898T>C	ENST00000359028.2	+	49	11874	c.11649T>C	c.(11647-11649)taT>taC	p.Y3883Y	AKAP9_ENST00000358100.2_Silent_p.Y3829Y|AKAP9_ENST00000356239.3_Silent_p.Y3879Y			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3883					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TAACAGATTATATCACTCGGC	0.478000			T	BRAF	papillary thyroid								16	37					0	0	1	0	0
HN1L	90861	broad.mit.edu	37	16	1735475	1735475	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr16:1735475T>G	ENST00000248098.3	+	2	137	c.80T>G	c.(79-81)cTt>cGt	p.L27R	HN1L_ENST00000569765.1_Missense_Mutation_p.L55R|HN1L_ENST00000562684.1_Missense_Mutation_p.L55R|HN1L_ENST00000569256.1_Intron|LA16c-431H6.6_ENST00000454337.1_3'UTR|HN1L_ENST00000382710.4_Missense_Mutation_p.L15R|HN1L_ENST00000382711.5_Missense_Mutation_p.L11R|HN1L_ENST00000561516.1_Missense_Mutation_p.L27R	NM_144570.2	NP_653171.1	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	27						cytoplasm|nucleus				endometrium(3)|kidney(2)|lung(3)|upper_aerodigestive_tract(1)	9						TCGAGCAATCTTTTTGGAAGT	0.473000													33	41					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10897294	10897294	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:10897294A>T	ENST00000314646.5	+	7	1068	c.904A>T	c.(904-906)Agc>Tgc	p.S302C	DNM2_ENST00000408974.4_Missense_Mutation_p.S302C|DNM2_ENST00000359692.6_Missense_Mutation_p.S302C|DNM2_ENST00000355667.6_Missense_Mutation_p.S302C|DNM2_ENST00000389253.4_Missense_Mutation_p.S302C|DNM2_ENST00000585892.1_Missense_Mutation_p.S302C			P50570	DYN2_HUMAN	dynamin 2	302					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CAAACTACAGAGCCAGCTGCT	0.592000			"""F, N, Splice, Mis, O"""		ETP ALL								23	57					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111539828	111539828	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:111539828C>T	ENST00000354925.2	-	7	2112	c.407G>A	c.(406-408)cGt>cAt	p.R136H	PITX2_ENST00000556049.1_5'UTR|PITX2_ENST00000394595.3_Silent_p.S67S|PITX2_ENST00000306732.3_Missense_Mutation_p.R143H|PITX2_ENST00000394598.2_Missense_Mutation_p.R136H|PITX2_ENST00000355080.5_Missense_Mutation_p.R90H	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	136			R -> C (in RIEG1).		determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		TTTGGCCCGACGATTCTTGAA	0.582000													19	81					0	0	1	0	0
RNF182	221687	broad.mit.edu	37	6	13977405	13977405	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:13977405G>C	ENST00000488300.1	+	3	578	c.55G>C	c.(55-57)Gag>Cag	p.E19Q	RNF182_ENST00000537388.1_Missense_Mutation_p.E19Q|RNF182_ENST00000537663.1_Missense_Mutation_p.E19Q|RNF182_ENST00000544682.1_Missense_Mutation_p.E19Q	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	19						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			TGATGAGCTGGAGTGCAAAAT	0.458000													26	82					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107245283	107245283	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:107245283G>C	ENST00000392837.4	+	7	1368	c.1217G>C	c.(1216-1218)aGa>aCa	p.R406T	RIC8B_ENST00000392839.2_Missense_Mutation_p.R406T|RIC8B_ENST00000549643.1_Intron|RIC8B_ENST00000355478.2_Missense_Mutation_p.R366T			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	406					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						TCAACTGTGAGAAATAAGCTG	0.443000													19	31					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728308	20728308	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:20728308C>T	ENST00000427401.4	-	4	795	c.701G>A	c.(700-702)tGt>tAt	p.C234Y		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	234					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						GGCTTTGCCACAGTCTTCACA	0.408000													4	13					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293465	145293465	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:145293465C>T	ENST00000342960.5	+	1	95	c.60C>T	c.(58-60)atC>atT	p.I20I	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Silent_p.I20I	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	20										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTCTAGAAATCAACGAGACAT	0.527000													31	580					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144381701	144381701	+	Splice_Site	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:144381701G>A	ENST00000295095.6	+	12	1170		c.e12-1			NM_018460.3	NP_060930.3	Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15						regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGTTTTCCCAGAAGAGAAGCT	0.453000													14	40					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237617746	237617746	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:237617746G>C	ENST00000366574.2	+	15	1665	c.1348G>C	c.(1348-1350)Gag>Cag	p.E450Q	RYR2_ENST00000542537.1_Missense_Mutation_p.E434Q|RYR2_ENST00000360064.6_Missense_Mutation_p.E448Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	450					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTGCCTATAGAGTCCGTAAG	0.448000													11	27					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74141917	74141917	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:74141917G>C	ENST00000409624.1	+	8	1367	c.724G>C	c.(724-726)Gag>Cag	p.E242Q	ACTG2_ENST00000345517.3_Missense_Mutation_p.E242Q|ACTG2_ENST00000409731.3_Missense_Mutation_p.E199Q			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	242					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						GAAGAGCTATGAGCTGCCAGA	0.537000													16	42					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110456955	110456955	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:110456955A>C	ENST00000260283.4	-	13	1684	c.1400T>G	c.(1399-1401)aTa>aGa	p.I467R	ARHGAP20_ENST00000529591.1_Missense_Mutation_p.I10R|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.I431R|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.I431R|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.I441R|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.I441R|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.I444R	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	467	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		AACAGTATTTATTTTCTCTTC	0.264000													18	26					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134232846	134232846	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:134232846C>T	ENST00000250160.6	+	3	478	c.372C>T	c.(370-372)gtC>gtT	p.V124V	WISP1_ENST00000220856.6_Intron|WISP1_ENST00000517423.1_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000377863.2_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	124	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TGGGCTGCGTCCTGGATGGGG	0.642000													20	106					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109937499	109937499	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:109937499C>T	ENST00000342494.3	+	12	1597	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F	UBE3B_ENST00000280774.5_Silent_p.F334F|UBE3B_ENST00000434735.2_Silent_p.F334F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	334					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CAGATGGGTTCGTGAGTTTGC	0.557000													6	16					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33134654	33134654	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:33134654G>A	ENST00000342462.4	-	2	1224	c.1034C>T	c.(1033-1035)tCt>tTt	p.S345F	GLB1_ENST00000445488.2_Intron|TMPPE_ENST00000416695.2_Missense_Mutation_p.S208F|GLB1_ENST00000399402.3_Intron|GLB1_ENST00000307363.5_Intron|GLB1_ENST00000307377.8_Intron	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	345						integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						GCCATGGCCAGAGTAGTGCAG	0.592000													73	45					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35715165	35715165	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:35715165T>G	ENST00000314888.9	-	21	2998	c.2645A>C	c.(2644-2646)gAc>gCc	p.D882A	TLN1_ENST00000540444.1_Missense_Mutation_p.D882A	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	882					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTCCTCACTGTCAGGGTGGGC	0.597000													14	36					0	0	1	0	0
ZBTB3	79842	broad.mit.edu	37	11	62520755	62520755	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:62520755C>T	ENST00000394807.3	-	2	657	c.532G>A	c.(532-534)Gac>Aac	p.D178N		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						TTGGTACTGTCTGCCTCTGCC	0.552000													33	103					0	0	1	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273377	145273377	+	Silent	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:145273377G>C	ENST00000369340.3	+	4	675	c.231G>C	c.(229-231)ctG>ctC	p.L77L	RP11-458D21.5_ENST00000468030.1_Silent_p.L77L|NOTCH2NL_ENST00000344859.3_Silent_p.L77L|NOTCH2NL_ENST00000362074.6_Silent_p.L77L			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	77	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						GACCTTGCCTGAATGGCGGCA	0.532000													29	351					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44832582	44832582	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:44832582T>A	ENST00000354340.4	-	4	1779	c.1728A>T	c.(1726-1728)aaA>aaT	p.K576N	ZNF112_ENST00000536500.1_Missense_Mutation_p.K599N|ZNF112_ENST00000337401.4_Missense_Mutation_p.K582N	NM_013380.3	NP_037512.3			zinc finger protein 112																		ATTCCTCACATTTATAAGGTT	0.438000													48	95					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530351	80530351	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:80530351C>G	ENST00000295057.3	-	2	1250	c.594G>C	c.(592-594)aaG>aaC	p.K198N	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000541047.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.K198N|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	198						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GCGCCAGACTCTTGAGCTGAT	0.587000										HNSCC(69;0.2)			33	81					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161113252	161113252	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:161113252G>A	ENST00000523217.1	+	2	297	c.55G>A	c.(55-57)Ggg>Agg	p.G19R	GABRA6_ENST00000522269.1_3'UTR|GABRA6_ENST00000274545.5_Missense_Mutation_p.G19R	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	19					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAATGCCCTAGGGAAACTCGA	0.473000										TCGA Ovarian(5;0.080)			15	32					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40453425	40453425	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:40453425C>T	ENST00000345506.4	+	10	1764	c.1122C>T	c.(1120-1122)atC>atT	p.I374I	STAT5A_ENST00000452307.2_Silent_p.I374I|STAT5A_ENST00000546010.2_Silent_p.I344I|STAT5A_ENST00000590949.1_Silent_p.I374I|STAT5A_ENST00000588868.1_Silent_p.I374I	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	374					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CCACCATCATCAGTGAGCAGC	0.577000													28	56					0	0	1	0	0
DCPS	28960	broad.mit.edu	37	11	126215347	126215347	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:126215347T>A	ENST00000263579.4	+	6	1182	c.853T>A	c.(853-855)Ttc>Atc	p.F285I	DCPS_ENST00000530860.1_3'UTR	NM_014026.3	NP_054745.1	Q96C86	DCPS_HUMAN	decapping enzyme, scavenger	285					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		CGCCCTGGGCTTCGAGGCCCC	0.632000													26	76					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323336	15323336	+	RNA	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:15323336G>A	ENST00000455308.2	-	0	512					NR_027417.1																						TTTCCTTATGGCCAATAAAAG	0.289000													3	6					0	0	1	0	0
SMYD4	114826	broad.mit.edu	37	17	1703375	1703375	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:1703375T>C	ENST00000305513.7	-	5	1480	c.1313A>G	c.(1312-1314)gAg>gGg	p.E438G		NM_052928.2	NP_443160.2	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	438							zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(5)|stomach(1)	21						GAATTTGTGCTCTGGGCTATG	0.453000													22	69					0	0	1	0	0
CSNK1G2	1455	broad.mit.edu	37	19	1979345	1979345	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:1979345A>C	ENST00000255641.8	+	8	1291	c.796A>C	c.(796-798)Aag>Cag	p.K266Q		NM_001319.6	NP_001310.3	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	266	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)|skin(1)|stomach(1)	8		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGTACCAGAAGATCGGGGA	0.716000													3	10					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33451109	33451109	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:33451109C>T	ENST00000256261.4	-	3	895	c.378G>A	c.(376-378)atG>atA	p.M126I	DUSP26_ENST00000523956.1_Missense_Mutation_p.M126I	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	126	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		AGTGGATGCTCATGTCAAAGG	0.647000													23	49					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19217186	19217186	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:19217186G>A	ENST00000318596.7	+	6	640	c.489G>A	c.(487-489)ccG>ccA	p.P163P	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	163					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			CCGTAACCCCGAAGGAAATGT	0.657000													17	40					0	0	1	0	0
CACNB3	784	broad.mit.edu	37	12	49220822	49220822	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:49220822C>T	ENST00000301050.2	+	12	1255	c.1056C>T	c.(1054-1056)taC>taT	p.Y352Y	CACNB3_ENST00000547392.1_Silent_p.Y325Y|CACNB3_ENST00000547230.1_Silent_p.Y311Y|CACNB3_ENST00000540990.1_Silent_p.Y339Y|CACNB3_ENST00000536187.2_Silent_p.Y351Y	NM_000725.3	NP_000716.2	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3 subunit	352					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(1)|large_intestine(5)|lung(4)|prostate(1)	12					Verapamil(DB00661)	TGGCTGAGTACCTGGAGGTTT	0.607000													51	135					0	0	1	0	0
UTP14A	10813	broad.mit.edu	37	X	129059987	129059987	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:129059987A>T	ENST00000394422.3	+	13	1870	c.1842A>T	c.(1840-1842)gaA>gaT	p.E614D	UTP14A_ENST00000371051.5_Missense_Mutation_p.E560D|UTP14A_ENST00000425117.2_Missense_Mutation_p.E562D|UTP14A_ENST00000371042.3_Missense_Mutation_p.E446D|RP4-537K23.4_ENST00000432062.1_RNA	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	614					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						AGAAGAGGGAAGCTGTGGAGG	0.527000											OREG0019920	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	8					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173232894	173232894	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:173232894G>A	ENST00000506823.1	+	4	1034	c.377G>A	c.(376-378)cGt>cAt	p.R126H	GALNTL6_ENST00000457021.1_3'UTR|GALNTL6_ENST00000508122.1_Missense_Mutation_p.R109H	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	126						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						CCAGATATTCGTCATGCTAAG	0.373000													41	128					0	0	1	0	0
FAM96A	84191	broad.mit.edu	37	15	64380932	64380932	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:64380932G>A	ENST00000557835.1	-	2	269	c.243C>T	c.(241-243)atC>atT	p.I81I	FAM96A_ENST00000300030.3_Silent_p.I81I|FAM96A_ENST00000380290.3_Silent_p.I81I|FAM96A_ENST00000559950.1_Silent_p.I81I			Q9H5X1	FA96A_HUMAN	family with sequence similarity 96, member A	81					chromosome segregation					kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						GCGTGAACCTGATAATAACCA	0.373000													4	18					0	0	1	0	0
MLYCD	23417	broad.mit.edu	37	16	83948911	83948911	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr16:83948911C>G	ENST00000262430.4	+	5	1318	c.1299C>G	c.(1297-1299)atC>atG	p.I433M	RP11-505K9.4_ENST00000561562.1_RNA	NM_012213.2	NP_036345.2	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase	433					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						TGTGGCGCATCAACTGGATGG	0.647000													34	98					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26915839	26915839	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:26915839G>A	ENST00000231021.4	-	3	594	c.422C>T	c.(421-423)cCg>cTg	p.P141L		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	141	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTCCGATTCCGGTTCCACCTG	0.398000													33	77					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113238804	113238804	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:113238804A>T	ENST00000369644.1	+	13	2675	c.1646A>T	c.(1645-1647)tAt>tTt	p.Y549F	MOV10_ENST00000413052.2_Missense_Mutation_p.Y605F|MOV10_ENST00000369645.1_Missense_Mutation_p.Y605F|MOV10_ENST00000357443.2_Missense_Mutation_p.Y605F|MOV10_ENST00000468624.1_3'UTR|RP11-426L16.3_ENST00000421943.1_RNA			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	605					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		AAGGGGGAGTATGTATTTCCC	0.547000													8	25					0	0	1	0	0
B2M	567	broad.mit.edu	37	15	45007745	45007745	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:45007745G>C	ENST00000558401.1	+	2	262	c.192G>C	c.(190-192)gaG>gaC	p.E64D	B2M_ENST00000559916.1_Missense_Mutation_p.E64D|B2M_ENST00000544417.1_Missense_Mutation_p.E64D|B2M_ENST00000559220.1_Intron	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	64	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.K61_L74del(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		AGAATGGAGAGAGAATTGAAA	0.413000													20	57					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153249385	153249385	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:153249385G>C	ENST00000281708.4	-	9	2622	c.1393C>G	c.(1393-1395)Cgt>Ggt	p.R465G	FBXW7_ENST00000263981.5_Missense_Mutation_p.R385G|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347G|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465G|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289G|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								24	100					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91260237	91260237	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:91260237T>C	ENST00000369329.3	-	9	1060	c.899A>G	c.(898-900)tAt>tGt	p.Y300C	MAP3K7_ENST00000369325.3_Missense_Mutation_p.Y300C|MAP3K7_ENST00000369320.1_5'UTR|MAP3K7_ENST00000369332.3_Missense_Mutation_p.Y300C|MAP3K7_ENST00000369327.3_Missense_Mutation_p.Y300C	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	300					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGACAAGGATACTGTAATGG	0.333000													3	16					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26213017	26213017	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:26213017C>T	ENST00000379034.1	+	2	1203	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	352	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CAACAGTGATCCTCCATGCTA	0.512000													64	21					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	33684434	33684434	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr14:33684434C>T	ENST00000346562.2	+	2	171	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C	NPAS3_ENST00000551008.1_5'UTR|NPAS3_ENST00000357798.5_Missense_Mutation_p.R33C|NPAS3_ENST00000551492.1_Missense_Mutation_p.R70C|NPAS3_ENST00000548645.1_Missense_Mutation_p.R33C|NPAS3_ENST00000341321.4_Missense_Mutation_p.R63C|NPAS3_ENST00000356141.4_Missense_Mutation_p.R63C|NPAS3_ENST00000547068.1_5'UTR	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TGCTCGCTCCCGCCGGGGAAA	0.458000													12	41					0	0	1	0	0
SAP30BP	29115	broad.mit.edu	37	17	73664664	73664664	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:73664664G>C	ENST00000584667.1	+	2	432	c.175G>C	c.(175-177)Gat>Cat	p.D59H	SAP30BP_ENST00000355423.3_Missense_Mutation_p.D59H|SAP30BP_ENST00000579864.1_3'UTR	NM_013260.6	NP_037392.1	Q9UHR5	S30BP_HUMAN	SAP30 binding protein	59					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)	17	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGTGATGAAGATGGTTATGA	0.408000													18	40					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936814	4936814	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:4936814C>T	ENST00000322013.3	-	1	108	c.80G>A	c.(79-81)cGc>cAc	p.R27H	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GATGTGCATGCGCTCCAGCCC	0.527000													18	56					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5410702	5410702	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:5410702G>C	ENST00000399537.4	-	11	3871	c.3523C>G	c.(3523-3525)Ctg>Gtg	p.L1175V	TNRC18_ENST00000430969.1_Missense_Mutation_p.L1175V			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1175	Pro-rich.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGCGACTCCAGAGGCGGCAGC	0.711000													14	54					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31601231	31601231	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:31601231G>A	ENST00000376033.2	+	17	4629	c.4395G>A	c.(4393-4395)ctG>ctA	p.L1465L	PRRC2A_ENST00000376007.4_Silent_p.L1465L	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1465	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TCTTCCGCCTGGACCAAGTTA	0.612000													18	54					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3528031	3528031	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:3528031G>A	ENST00000262919.5	+	5	906	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	ATRN_ENST00000446916.2_Missense_Mutation_p.E280K	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	280					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGGAAAGGTGAAGCATGTGA	0.438000													13	56					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530608	80530608	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:80530608G>A	ENST00000295057.3	-	2	993	c.337C>T	c.(337-339)Cgc>Tgc	p.R113C	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000541047.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.R113C|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	113						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						TTAACTCGGCGCAGTTTCTGA	0.597000										HNSCC(69;0.2)			5	140					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28354392	28354392	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:28354392G>T	ENST00000373871.3	-	7	647	c.407C>A	c.(406-408)aCt>aAt	p.T136N	EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000436342.2_Missense_Mutation_p.T10N|EYA3_ENST00000373863.3_Intron|EYA3_ENST00000373864.1_Intron|EYA3_ENST00000545175.1_Missense_Mutation_p.T83N|EYA3_ENST00000540618.1_Intron			Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	136					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TGGAGATGGAGTCTGAATTAA	0.433000													31	70					1.99505e-19	2.13819e-19	1	1	0
BMP2K	55589	broad.mit.edu	37	4	79792085	79792085	+	Missense_Mutation	SNP	G	G	C	rs71828885		TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:79792085G>C	ENST00000335016.5	+	11	1546	c.1380G>C	c.(1378-1380)caG>caC	p.Q460H	BMP2K_ENST00000502871.1_Missense_Mutation_p.Q460H	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	460	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity	p.Q460H(3)		NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						ATCCTCACcagcagcagcagc	0.577000													4	44					0	0	1	0	0
ELP3	55140	broad.mit.edu	37	8	27995295	27995295	+	Silent	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:27995295T>C	ENST00000256398.8	+	10	1364	c.987T>C	c.(985-987)taT>taC	p.Y329Y	ELP3_ENST00000521015.1_Silent_p.Y315Y|ELP3_ENST00000537665.1_Silent_p.Y210Y|ELP3_ENST00000542181.1_Silent_p.Y200Y|ELP3_ENST00000380353.4_Silent_p.Y237Y|ELP3_ENST00000524103.1_Silent_p.Y257Y	NM_018091.5	NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	329					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		CCGGGCTTTATGAGCTTTGGA	0.488000													17	28					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65271665	65271665	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr14:65271665C>G	ENST00000389722.3	-	2	345	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	SPTB_ENST00000556626.1_Missense_Mutation_p.E98Q|SPTB_ENST00000542895.1_Missense_Mutation_p.E98Q|SPTB_ENST00000389720.3_Missense_Mutation_p.E98Q|SPTB_ENST00000389721.5_Missense_Mutation_p.E98Q	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	98	Actin-binding.|CH 1.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ACCAGCATCTCTCCAGAGAGC	0.607000													48	92					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52695816	52695816	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:52695816G>A	ENST00000293525.5	+	1	168	c.116G>A	c.(115-117)cGc>cAc	p.R39H	KRT86_ENST00000544024.1_Missense_Mutation_p.R39H|KRT86_ENST00000423955.2_Missense_Mutation_p.R39H	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	39	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCTGCTACCGCGGCCTCACC	0.746000													14	38					0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51497226	51497226	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:51497226C>G	ENST00000335891.5	-	4	288	c.279G>C	c.(277-279)gtG>gtC	p.V93V				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	93					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		GGCTTGTCATCACATATGCAT	0.398000													8	11					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													3	30					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39504133	39504133	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:39504133G>C	ENST00000518318.2	+	10	1858	c.1816G>C	c.(1816-1818)Gag>Cag	p.E606Q	POU6F2_ENST00000559001.1_Missense_Mutation_p.E587Q|POU6F2_ENST00000403058.1_Missense_Mutation_p.E642Q			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	642					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CGAAATTGCTGAGAAGCTGAA	0.502000													14	27					0	0	1	0	0
PNPLA4	8228	broad.mit.edu	37	X	7870135	7870135	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:7870135G>A	ENST00000381042.4	-	6	695	c.525C>T	c.(523-525)gtC>gtT	p.V175V	PNPLA4_ENST00000537427.1_Silent_p.V88V|PNPLA4_ENST00000444736.1_Silent_p.V175V	NM_004650.2	NP_004641.1	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	175	Patatin.				lipid catabolic process		triglyceride lipase activity			kidney(1)|large_intestine(3)|lung(2)|prostate(1)	7		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				CTGTCCGGCCGACGGGCAGGA	0.547000													18	33					0	0	1	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253775	32253775	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr21:32253775C>T	ENST00000332378.4	-	1	99	c.69G>A	c.(67-69)gtG>gtA	p.V23V		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	23						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						TAACTTGGGCCACTGGAACAA	0.557000													24	68					0	0	1	0	0
WDR5B	54554	broad.mit.edu	37	3	122133836	122133836	+	Silent	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:122133836G>T	ENST00000330689.4	-	1	1046	c.540C>A	c.(538-540)tcC>tcA	p.S180S		NM_019069.3	NP_061942.2	Q86VZ2	WDR5B_HUMAN	WD repeat domain 5B	180										kidney(2)|large_intestine(4)|lung(2)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	13				GBM - Glioblastoma multiforme(114;0.0704)		ACACTATCAAGGACCCACTAC	0.433000													24	67					3.28513e-13	3.47409e-13	1	1	0
SYNPO2L	79933	broad.mit.edu	37	10	75407449	75407449	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:75407449G>A	ENST00000394810.2	-	4	2110	c.1961C>T	c.(1960-1962)tCg>tTg	p.S654L	SYNPO2L_ENST00000372872.4_Intron|SYNPO2L_ENST00000372873.4_Missense_Mutation_p.S430L	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	654	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CTGTACCAGCGATAGCAGCTC	0.627000													37	145					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580247	35580247	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:35580247G>A	ENST00000373330.1	+	11	2990	c.2816G>A	c.(2815-2817)aGa>aAa	p.R939K	ZMYM1_ENST00000373329.1_3'UTR|ZMYM1_ENST00000359858.4_Missense_Mutation_p.R939K			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	939						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGAAAAGAAGAAAAATTCAG	0.284000													3	14					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													3	61					1	1	1	1	0
CEP104	9731	broad.mit.edu	37	1	3753141	3753141	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:3753141C>T	ENST00000378230.3	-	10	1559	c.1235G>A	c.(1234-1236)gGc>gAc	p.G412D	CEP104_ENST00000460038.1_Intron	NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	412						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						CCCTAACATGCCTCCCCTCCG	0.507000													30	73					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182346359	182346359	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:182346359G>A	ENST00000397033.2	+	7	1219	c.789G>A	c.(787-789)caG>caA	p.Q263Q		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	263					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TTCGGAGCCAGCATACTACCG	0.373000													3	16					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45750164	45750164	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr7:45750164C>T	ENST00000297323.7	+	19	2992	c.2970C>T	c.(2968-2970)ggC>ggT	p.G990G		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	990					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GAGTGATTGGCGCTCGCAGGC	0.577000													45	63					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30729875	30729875	+	Splice_Site	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:30729875G>A	ENST00000295754.5	+	6	1778		c.e6-1		TGFBR2_ENST00000359013.4_Splice_Site	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)						activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						TTTCTTCACAGAAGTAAAAGA	0.512000													37	32					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30077427	30077427	+	Splice_Site	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr22:30077427G>A	ENST00000338641.4	+	15	2015		c.e15-1		NF2_ENST00000361452.4_Splice_Site|NF2_ENST00000334961.7_Splice_Site|NF2_ENST00000361166.4_Splice_Site|NF2_ENST00000403435.1_Splice_Site|NF2_ENST00000361676.4_Splice_Site|NF2_ENST00000397789.3_Splice_Site|NF2_ENST00000347330.5_Splice_Site|NF2_ENST00000353887.4_Splice_Site|NF2_ENST00000403999.3_Splice_Site|NF2_ENST00000413209.2_Intron	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)						actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(6)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						CTTGCCGGCAGAGTGGAATAC	0.537000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				68	47					0	0	1	0	0
TRAPPC2	6399	broad.mit.edu	37	X	13734173	13734173	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:13734173C>T	ENST00000453655.2	-	5	566	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	TRAPPC2_ENST00000358231.5_Missense_Mutation_p.E92K|TRAPPC2_ENST00000458511.2_Missense_Mutation_p.E126K|TRAPPC2_ENST00000359680.5_Missense_Mutation_p.E92K|TRAPPC2_ENST00000380579.1_Missense_Mutation_p.E92K|TRAPPC2_ENST00000519885.1_Missense_Mutation_p.E92K	NM_001011658.3|NM_001128835.2	NP_001011658.1|NP_001122307.2	Q6IBE5	Q6IBE5_HUMAN	trafficking protein particle complex 2	92					ER to Golgi vesicle-mediated transport	intracellular				kidney(1)	1						ATTCCATCTTCTTGTCTTATG	0.279000													4	11					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118949908	118949908	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:118949908G>T	ENST00000328252.3	+	2	1260	c.891G>T	c.(889-891)tgG>tgT	p.W297C		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	297	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AGCATGCCTGGTCCCCCATGA	0.577000													23	73					3.10358e-05	3.14303e-05	1	1	0
MAGEA12	4111	broad.mit.edu	37	X	151899861	151899861	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:151899861C>G	ENST00000393900.3	-	3	1293	c.940G>C	c.(940-942)Gag>Cag	p.E314Q	MAGEA12_ENST00000357916.4_Missense_Mutation_p.E314Q|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.E314Q	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	314										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CAGACTCACTCTTCCCCCTCT	0.552000													50	100					0	0	1	0	0
NACC1	112939	broad.mit.edu	37	19	13246121	13246121	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr19:13246121G>C	ENST00000292431.4	+	2	226	c.100G>C	c.(100-102)Gtg>Ctg	p.V34L		NM_052876.3	NP_443108.1	Q96RE7	NACC1_HUMAN	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	34	BTB.				negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body				endometrium(3)|large_intestine(2)|lung(3)|skin(1)	9						TGACGTGTCAGTGGTGGTCAA	0.617000													14	71					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30723310	30723310	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:30723310G>A	ENST00000361762.2	+	1	1274	c.266G>A	c.(265-267)cGg>cAg	p.R89Q	PCDH7_ENST00000543491.1_Missense_Mutation_p.R89Q	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	89	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						ACGAGCGAGCGGCGCATCGAC	0.617000													4	27					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113308070	113308070	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:113308070G>A	ENST00000297405.5	-	54	8850	c.8606C>T	c.(8605-8607)tCc>tTc	p.S2869F	CSMD3_ENST00000343508.3_Missense_Mutation_p.S2829F|CSMD3_ENST00000352409.3_Missense_Mutation_p.S2799F|CSMD3_ENST00000455883.2_Missense_Mutation_p.S2700F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2869	Sushi 18.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACGCACACAGGATGGGAGCTG	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	33					0	0	1	0	0
B3GAT3	26229	broad.mit.edu	37	11	62384631	62384631	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:62384631T>C	ENST00000531383.1	-	3	652	c.446A>G	c.(445-447)gAg>gGg	p.E149G	B3GAT3_ENST00000534026.1_Missense_Mutation_p.E149G|B3GAT3_ENST00000265471.5_Missense_Mutation_p.E149G			O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	149					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)|urinary_tract(1)	12						CCAGCCAGGCTCGCCCTCCCG	0.692000													18	32					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25819047	25819047	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:25819047G>C	ENST00000406818.3	-	6	760	c.511C>G	c.(511-513)Ctg>Gtg	p.L171V	DTNB_ENST00000472690.1_5'UTR|DTNB_ENST00000407661.3_Missense_Mutation_p.L171V|DTNB_ENST00000407038.3_Missense_Mutation_p.L171V|DTNB_ENST00000407186.1_Missense_Mutation_p.L171V|DTNB_ENST00000405222.1_Missense_Mutation_p.L171V|DTNB_ENST00000545439.1_Intron|DTNB_ENST00000496972.2_Missense_Mutation_p.L114V|DTNB_ENST00000404103.3_Missense_Mutation_p.L171V|DTNB_ENST00000288642.8_Missense_Mutation_p.L171V	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	171						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTTCCTTCAGAAACTGGTCA	0.423000													16	29					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130272455	130272455	+	Silent	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:130272455G>A	ENST00000373312.3	-	9	1344	c.1131C>T	c.(1129-1131)atC>atT	p.I377I	FAM129B_ENST00000373314.3_Silent_p.I364I|FAM129B_ENST00000468379.1_Intron	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	377							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CGCCCTCGTTGATGACGTTCA	0.632000													61	90					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150676644	150676644	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:150676644C>T	ENST00000368993.2	-	12	1003	c.898G>A	c.(898-900)Gaa>Aaa	p.E300K	HORMAD1_ENST00000368995.4_Missense_Mutation_p.E220K|HORMAD1_ENST00000322343.7_Missense_Mutation_p.E293K|HORMAD1_ENST00000361824.2_Missense_Mutation_p.E300K			Q86X24	HORM1_HUMAN	HORMA domain containing 1	300					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			CTCATAATTTCATCTTCCTCA	0.303000													4	5					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8131545	8131545	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:8131545C>G	ENST00000315684.8	-	23	3614	c.3607G>C	c.(3607-3609)Gag>Cag	p.E1203Q		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	1203					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TACTCTGACTCTCGGATAGAA	0.547000													14	29					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	591898	591898	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:591898G>C	ENST00000381578.1	+	2	957	c.266G>C	c.(265-267)aGa>aCa	p.R89T	SHOX_ENST00000334060.3_Missense_Mutation_p.R89T|SHOX_ENST00000554971.1_Missense_Mutation_p.R89T|SHOX_ENST00000381575.1_Missense_Mutation_p.R89T	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	89					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCACCGCGAGAGTGGCAGAA	0.652000													29	70					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114352855	114352855	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:114352855G>A	ENST00000545145.2	-	21	2555	c.2477C>T	c.(2476-2478)cCc>cTc	p.P826L	RBM19_ENST00000392561.3_Missense_Mutation_p.P826L|RBM19_ENST00000261741.5_Missense_Mutation_p.P826L	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	826					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CTGCTTTCTGGGAACTTGTTT	0.572000													30	93					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43412147	43412147	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr21:43412147C>A	ENST00000310826.5	-	3	2241	c.2058G>T	c.(2056-2058)aaG>aaT	p.K686N	ZBTB21_ENST00000398499.1_Missense_Mutation_p.K686N|ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398511.3_Missense_Mutation_p.K686N|ZBTB21_ENST00000398505.3_Intron	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		TTATATGCTGCTTAAATTGAG	0.418000													35	110					9.04072e-19	9.64612e-19	1	1	0
ZBTB3	79842	broad.mit.edu	37	11	62521034	62521034	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr11:62521034A>G	ENST00000394807.3	-	2	378	c.253T>C	c.(253-255)Ttc>Ctc	p.F85L		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	85	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						TGGGCCAAGAACTGGGTACTA	0.572000													11	24					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89053960	89053960	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr8:89053960T>C	ENST00000286614.6	-	10	1834	c.1553A>G	c.(1552-1554)gAa>gGa	p.E518G		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	518	Hemopexin-like 4.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						ATATCCAGGTTCTACCTTGAG	0.423000													10	53					0	0	1	0	0
DNAJC28	54943	broad.mit.edu	37	21	34861415	34861415	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr21:34861415C>G	ENST00000314399.3	-	2	724	c.286G>C	c.(286-288)Gaa>Caa	p.E96Q	DNAJC28_ENST00000381947.3_Missense_Mutation_p.E96Q|DNAJC28_ENST00000402202.1_Missense_Mutation_p.E96Q	NM_017833.3	NP_060303.2	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	96	J.						heat shock protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(5)|skin(1)|urinary_tract(1)	18						TAAGCTTTTTCAATCCTTATA	0.368000													16	52					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40916382	40916382	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr15:40916382A>T	ENST00000346991.5	+	11	4388	c.3998A>T	c.(3997-3999)aAt>aTt	p.N1333I	CASC5_ENST00000399668.2_Missense_Mutation_p.N1307I			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1333					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGTTTACCAAATGTTATTTCC	0.363000													22	60					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51612983	51612983	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:51612983A>G	ENST00000371117.3	-	58	9706	c.9431T>C	c.(9430-9432)aTc>aCc	p.I3144T	PKHD1_ENST00000340994.4_Missense_Mutation_p.I3144T	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3144					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GAAGCCAGAGATTCTGGTACA	0.428000													63	143					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6525470	6525470	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr10:6525470G>C	ENST00000263125.5	-	11	1210	c.1111C>G	c.(1111-1113)Ctg>Gtg	p.L371V	PRKCQ_ENST00000397176.2_Missense_Mutation_p.L371V|PRKCQ_ENST00000539722.1_Missense_Mutation_p.L246V	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	371					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TTAATCTGCAGAGATGGTCTT	0.433000													28	77					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187535448	187535448	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:187535448G>C	ENST00000441802.2	-	12	9335	c.9126C>G	c.(9124-9126)atC>atG	p.I3042M		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3042	Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGATCTGCATGATCAATTTTC	0.388000										HNSCC(5;0.00058)			13	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587808	179587808	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr2:179587808C>T	ENST00000589042.1	-	75	22150	c.21926G>A	c.(21925-21927)gGa>gAa	p.G7309E	TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G6065E|TTN_ENST00000591111.1_Missense_Mutation_p.G6992E|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6992	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATCCCTTCCTGCCTCATT	0.378000													15	26					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119428695	119428695	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:119428695C>G	ENST00000273390.5	+	5	530	c.453C>G	c.(451-453)ctC>ctG	p.L151L	MAATS1_ENST00000463700.1_Silent_p.L151L	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		GGCCTTTTCTCCCATTTTTTC	0.353000													7	38					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214169881	214169881	+	Translation_Start_Site	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:214169881G>T	ENST00000366958.4	+	2	611	c.3G>T	c.(1-3)atG>atT	p.M1I	PROX1_ENST00000498508.2_Start_Codon_SNP_p.M1I|PROX1_ENST00000261454.4_Start_Codon_SNP_p.M1I|PROX1_ENST00000435016.1_Start_Codon_SNP_p.M1I	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	1					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GTCCAGTGATGCCTGACCATG	0.507000													12	35					7.03913e-09	7.34651e-09	1	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176983	140176983	+	Nonsense_Mutation	SNP	A	A	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:140176983A>T	ENST00000378132.1	+	1	2540	c.2434A>T	c.(2434-2436)Aaa>Taa	p.K812*	PCDHA2_ENST00000526136.1_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_031495.1	NP_113683.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTCTTTTTAAAAAATTCTA	0.308000													8	15					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060867	139060867	+	Silent	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:139060867C>T	ENST00000302517.3	+	2	1473	c.759C>T	c.(757-759)atC>atT	p.I253I	CXXC5_ENST00000511048.1_Silent_p.I253I|CXXC5_ENST00000515038.1_3'UTR	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	253					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCTGCCATCAGCTCCGGCA	0.632000													29	76					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146264650	146264650	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr6:146264650A>C	ENST00000367503.3	-	9	2265	c.1867T>G	c.(1867-1869)Ttc>Gtc	p.F623V	SHPRH_ENST00000275233.7_Missense_Mutation_p.F623V|SHPRH_ENST00000438092.2_Missense_Mutation_p.F623V|SHPRH_ENST00000367505.2_Missense_Mutation_p.F623V	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	623					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTGGTTGAATTCAGAGATA	0.403000													21	66					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21550081	21550081	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:21550081G>A	ENST00000425654.2	+	11	1679	c.1199G>A	c.(1198-1200)cGa>cAa	p.R400Q	CNKSR2_ENST00000379510.3_Missense_Mutation_p.R400Q|CNKSR2_ENST00000543067.1_Missense_Mutation_p.R351Q|CNKSR2_ENST00000485012.1_3'UTR|CNKSR2_ENST00000279451.4_Missense_Mutation_p.R400Q	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	400	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						CAGGAATATCGAAAGAGATTT	0.393000													18	46					0	0	1	0	0
SPRTN	83932	broad.mit.edu	37	1	231489080	231489080	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:231489080C>G	ENST00000295050.7	+	5	1779	c.1443C>G	c.(1441-1443)atC>atG	p.I481M		NM_001010984.2|NM_032018.5	NP_001010984.1|NP_114407.3			SprT-like N-terminal domain																		GTGACAGCATCAAAGTCAAAA	0.418000													12	37					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33956919	33956919	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:33956919G>T	ENST00000361328.3	+	6	1214	c.1061G>T	c.(1060-1062)cGc>cTc	p.R354L	ZSCAN20_ENST00000373413.2_Missense_Mutation_p.R300L	NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	354					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CACCAGAACCGCCAGGTATAT	0.517000													33	92					3.86903e-22	4.18415e-22	1	1	0
CXXC5	51523	broad.mit.edu	37	5	139061005	139061005	+	Silent	SNP	C	C	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr5:139061005C>G	ENST00000302517.3	+	2	1611	c.897C>G	c.(895-897)ctC>ctG	p.L299L	CXXC5_ENST00000511048.1_Silent_p.L299L|CXXC5_ENST00000515038.1_3'UTR	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	299					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGGAACTCAAAAAGAAGC	0.567000													42	133					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121410218	121410218	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr3:121410218C>T	ENST00000393667.3	-	14	8103	c.7993G>A	c.(7993-7995)Gaa>Aaa	p.E2665K	GOLGB1_ENST00000340645.5_Missense_Mutation_p.E2660K	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2660					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ACCAATTCTTCTTCCAGTTCT	0.373000													36	113					0	0	1	0	0
GPR137B	7107	broad.mit.edu	37	1	236305987	236305988	+	Frame_Shift_Ins	INS	-	-	C			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr1:236305987_236305988insC	ENST00000366592.3	+	1	156_157	c.65_66insC	c.(64-66)gccfs	p.A22fs	GPR137B_ENST00000366591.4_Frame_Shift_Ins_p.A22fs	NM_003272.3	NP_003263.1	O60478	G137B_HUMAN	G protein-coupled receptor 137B	22						integral to plasma membrane|membrane fraction				endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			CCGCCGTGGGACCCAGCCCGCA	0.772													4	9	---	---	---	---					
PIGG	54872	broad.mit.edu	37	4	524368	524370	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:524368_524370delTTC	ENST00000453061.2	+	11	2511_2513	c.2405_2407delTTC	c.(2404-2409)gtt>g	p.VL802del	PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000383028.4_In_Frame_Del_p.VL669del|PIGG_ENST00000310340.5_In_Frame_Del_p.VL794del|PIGG_ENST00000504346.1_In_Frame_Del_p.VL713del	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	802					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						AGTGGATTAGTTCTTCTGGCAGC	0.414													52	145	---	---	---	---					
RGS12	6002	broad.mit.edu	37	4	3430399	3430399	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr4:3430399delA	ENST00000336727.3	+	16	4430	c.3526delA	c.(3526-3528)aafs	p.K1178fs	RGS12_ENST00000382788.3_Frame_Shift_Del_p.K1178fs|RGS12_ENST00000344733.5_Frame_Shift_Del_p.K1178fs|RGS12_ENST00000338806.4_Frame_Shift_Del_p.K530fs|RGS12_ENST00000306648.7_Intron|RGS12_ENST00000538395.1_Intron	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1178						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAAGATTGGGAAAAAAAAATA	0.328													7	67	---	---	---	---					
SNORD118	727676	broad.mit.edu	37	9	38147473	38147473	+	RNA	DEL	A	A	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:38147473delA	ENST00000363156.1	+	0	49																											gagggcagatagaacatgatg	0.408													2	4	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													2	4	---	---	---	---					
KRT76	51350	broad.mit.edu	37	12	53162773	53162775	+	In_Frame_Del	DEL	ACT	ACT	-	rs1464423	by1000genomes	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr12:53162773_53162775delACT	ENST00000332411.2	-	9	1692_1694	c.1639_1641delAGT	c.(1639-1641)del	p.S547del		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	547	Tail.				cytoskeleton organization	keratin filament	structural molecule activity	p.S547_G548insS(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ctccatagccactgctgctgctg	0.635													2	4	---	---	---	---					
NFAT5	10725	broad.mit.edu	37	16	69726976	69726985	+	Frame_Shift_Del	DEL	CTCATTCACA	CTCATTCACA	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr16:69726976_69726985delCTCATTCACA	ENST00000349945.1	+	14	4518_4527	c.2966_2975delCTCATTCACA	c.(2965-2976)tgfs	p.SHSQ989fs	NFAT5_ENST00000566899.1_Frame_Shift_Del_p.SHSQ989fs|NFAT5_ENST00000432919.1_Frame_Shift_Del_p.SHSQ1083fs|NFAT5_ENST00000393742.2_Frame_Shift_Del_p.SHSQ989fs|NFAT5_ENST00000354436.2_Frame_Shift_Del_p.SHSQ1065fs|NFAT5_ENST00000567239.1_Frame_Shift_Del_p.SHSQ1082fs	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1065					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CAGCAGTCTTCTCATTCACAGGCCCAACTT	0.414													27	94	---	---	---	---					
TNK1	8711	broad.mit.edu	37	17	7291834	7291835	+	Frame_Shift_Ins	INS	-	-	G			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr17:7291834_7291835insG	ENST00000570896.1	+	12	2033_2034	c.1587_1588insG	c.(1585-1590)ccgcctfs	p.P530fs	TNK1_ENST00000576812.1_Frame_Shift_Ins_p.P535fs|TNK1_ENST00000311668.2_Frame_Shift_Ins_p.P530fs			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	535	Pro-rich.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				AGGGACCTCCAGGCCTGCCTCC	0.614													21	53	---	---	---	---					
SRSF6	6431	broad.mit.edu	37	20	42089617	42089619	+	In_Frame_Del	DEL	CCT	CCT	-	rs149557843	byFrequency	TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:42089617_42089619delCCT	ENST00000244020.3	+	6	1055_1057	c.949_951delCCT	c.(949-951)del	p.P319del		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	319	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						TTCTGTGTCCCCTCCACCAAAAA	0.478													22	75	---	---	---	---					
TOX2	84969	broad.mit.edu	37	20	42574639	42574651	+	Frame_Shift_Del	DEL	TGCAAGACACTGG	TGCAAGACACTGG	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chr20:42574639_42574651delTGCAAGACACTGG	ENST00000358131.5	+	1	295_307	c.87_99delTGCAAGACACTGG	c.(85-99)ctfs	p.LARHW29fs	TOX2_ENST00000423191.1_Intron|TOX2_ENST00000372999.1_Intron|TOX2_ENST00000341197.3_Intron	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.A30E(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TCCTTCTACTTGCAAGACACTGGTGCATTGCAG	0.587													7	40	---	---	---	---					
HUWE1	10075	broad.mit.edu	37	X	53592084	53592087	+	Frame_Shift_Del	DEL	GACT	GACT	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:53592084_53592087delGACT	ENST00000342160.3	-	49	7278_7281	c.6821_6824delAGTC	c.(6820-6825)atfs	p.KS2274fs	HUWE1_ENST00000262854.6_Frame_Shift_Del_p.KS2274fs			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2274					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ATCCTGCTCAGACTTGTTCTTGCT	0.520													37	33	---	---	---	---					
ARHGEF6	9459	broad.mit.edu	37	X	135825852	135825852	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A6II-01A-11D-A31L-08	TCGA-QK-A6II-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49d64104-0345-4a84-b039-c7d76631b300	4e6f3c43-f771-46e9-930d-113f837e12ae	g.chrX:135825852delC	ENST00000250617.6	-	5	1758	c.553delG	c.(553-555)acfs	p.D185fs	ARHGEF6_ENST00000370620.1_Frame_Shift_Del_p.D31fs|ARHGEF6_ENST00000535227.1_Frame_Shift_Del_p.D31fs|ARHGEF6_ENST00000370622.1_Frame_Shift_Del_p.D31fs	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	185	SH3.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					TAAATGATGTCCCCCTTACAA	0.423													77	52	---	---	---	---					
