Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPD2	2820	broad.mit.edu	37	2	157406233	157406233	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:157406233C>A	ENST00000310454.6	+	7	1147	c.775C>A	c.(775-777)Cag>Aag	p.Q259K	GPD2_ENST00000438166.2_Missense_Mutation_p.Q259K|GPD2_ENST00000540309.1_Missense_Mutation_p.Q259K|GPD2_ENST00000409125.4_Missense_Mutation_p.Q32K|GPD2_ENST00000409674.1_Missense_Mutation_p.Q259K	NM_001083112.2	NP_001076581.2	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	259					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|stomach(1)	22						GACAGACCCCCAGACAGGGAA	0.547000													4	51					0.000602214	0.000633556	1	1	0
SEPN1	57190	broad.mit.edu	37	1	26135118	26135118	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:26135118C>T	ENST00000361547.2	+	5	640	c.585C>T	c.(583-585)gcC>gcT	p.A195A	SEPN1_ENST00000354177.4_Silent_p.A161A|SEPN1_ENST00000374315.1_Silent_p.A161A	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	195						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCCGCCGCCTCACCAAGTG	0.662000													24	78					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66426264	66426264	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:66426264G>A	ENST00000341529.3	+	7	1343	c.1195G>A	c.(1195-1197)Gat>Aat	p.D399N	CDH5_ENST00000563425.2_Missense_Mutation_p.D399N	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	399	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CATGGACCCTGATGCGGCTAG	0.557000													26	74					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150931199	150931199	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:150931199C>G	ENST00000035307.2	+	1	1615	c.102C>G	c.(100-102)atC>atG	p.I34M	CHPF2_ENST00000495645.1_Missense_Mutation_p.I26M	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	34						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						TTTCCTGGATCCAGGGGGAGG	0.612000													4	72					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35166957	35166957	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr15:35166957C>G	ENST00000156471.5	-	29	3571	c.3346G>C	c.(3346-3348)Gag>Cag	p.E1116Q		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1116						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AGAGACTGCTCCATGTTTGAG	0.443000													7	95					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429174	179429174	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:179429174C>T	ENST00000589042.1	-	326	81909	c.81685G>A	c.(81685-81687)Gaa>Aaa	p.E27229K	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E24661K|TTN_ENST00000359218.5_Missense_Mutation_p.E18289K|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E18164K|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E25588K|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E18356K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25588	Fibronectin type-III 98.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGTAAATTCAGTTTCTAAT	0.378000													7	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179431877	179431877	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:179431877C>T	ENST00000589042.1	-	326	79206	c.78982G>A	c.(78982-78984)Gaa>Aaa	p.E26328K	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E23760K|TTN_ENST00000359218.5_Missense_Mutation_p.E17388K|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E17263K|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E24687K|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E17455K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24687	Ig-like 127.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGACTGGTTTCTCGCTTTTCA	0.413000													9	132					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44445164	44445164	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:44445164C>G	ENST00000378551.2	+	4	1435	c.1023C>G	c.(1021-1023)atC>atG	p.I341M	PPM1B_ENST00000409432.3_Missense_Mutation_p.I341M|PPM1B_ENST00000282412.4_Missense_Mutation_p.I341M|PPM1B_ENST00000378540.4_3'UTR|PPM1B_ENST00000345249.4_Missense_Mutation_p.I54M	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	341					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCATGCGCATCTTGTCTGCAG	0.388000													10	83					0	0	1	0	0
CHN2	1124	broad.mit.edu	37	7	29544431	29544431	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:29544431G>A	ENST00000222792.6	+	10	1515	c.985G>A	c.(985-987)Gac>Aac	p.D329N	CHN2_ENST00000435288.2_Intron|CHN2_ENST00000424025.2_Missense_Mutation_p.D148N|CHN2_ENST00000421775.2_Missense_Mutation_p.D135N|CHN2_ENST00000410098.1_3'UTR|CHN2_ENST00000546235.1_Missense_Mutation_p.D314N|CHN2_ENST00000409041.4_Missense_Mutation_p.D193N|CHN2_ENST00000539389.1_Missense_Mutation_p.D185N|CHN2_ENST00000439711.2_Missense_Mutation_p.D193N|CHN2_ENST00000539406.1_Missense_Mutation_p.D404N|CHN2_ENST00000495789.2_Missense_Mutation_p.D342N	NM_004067.2	NP_004058.1	P52757	CHIO_HUMAN	chimerin 2	329	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			breast(2)|endometrium(3)|large_intestine(2)|lung(12)|ovary(2)|urinary_tract(2)	23						AATGGCATTTGACAGAGGTAA	0.408000													6	73					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98274689	98274689	+	Missense_Mutation	SNP	C	C	T	rs151155439		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:98274689C>T	ENST00000289228.5	-	7	964	c.748G>A	c.(748-750)Gat>Aat	p.D250N		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	250						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						CCACTTACATCAAGCGTGCTG	0.622000													5	37					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546545	2546545	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:2546545C>T	ENST00000567020.1	+	2	536	c.396C>T	c.(394-396)ccC>ccT	p.P132P	RP11-20I23.1_ENST00000564543.1_Silent_p.P132P|TBC1D24_ENST00000434757.2_Silent_p.P132P|TBC1D24_ENST00000293970.5_Silent_p.P132P	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	132	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						CCTTCTGCCCCGCCCTGCCGG	0.682000													7	59					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38287971	38287971	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:38287971G>T	ENST00000373036.4	-	9	1729	c.1589C>A	c.(1588-1590)cCa>cAa	p.P530Q		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	530						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GACCATGGCTGGCAGGGGCTC	0.567000													4	40					0.184627	0.185941	1	1	0
ZSCAN10	84891	broad.mit.edu	37	16	3141583	3141583	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:3141583C>T	ENST00000252463.2	-	4	667	c.580G>A	c.(580-582)Gag>Aag	p.E194K	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.E112K|ZSCAN10_ENST00000575108.1_5'UTR|ZSCAN10_ENST00000572548.1_3'UTR	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	194					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GGCACATCCTCAAAGGTCAGG	0.512000													5	62					0	0	1	0	0
CPSF7	79869	broad.mit.edu	37	11	61183233	61183233	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:61183233G>C	ENST00000340437.4	-	7	1198	c.1118C>G	c.(1117-1119)tCt>tGt	p.S373C	CPSF7_ENST00000448745.1_Missense_Mutation_p.S321C|CPSF7_ENST00000439958.3_Missense_Mutation_p.S321C|CPSF7_ENST00000394888.4_Missense_Mutation_p.S330C	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	330					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						ACTCACTGTAGAGGGTGGAGG	0.438000													8	93					0	0	1	0	0
ZNF281	23528	broad.mit.edu	37	1	200377405	200377405	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:200377405T>C	ENST00000294740.2	-	2	1553	c.1429A>G	c.(1429-1431)Aaa>Gaa	p.K477E	ZNF281_ENST00000367353.1_Missense_Mutation_p.K477E|ZNF281_ENST00000367352.3_Missense_Mutation_p.K441E	NM_012482.3	NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	477					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						AGGTAGTTTTTATCTGTATTC	0.398000													8	112					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373805	126373805	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:126373805C>T	ENST00000394329.3	+	9	11647	c.11634C>T	c.(11632-11634)caC>caT	p.H3878H	FAT4_ENST00000335110.5_Silent_p.H2176H	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3878	EGF-like 2; calcium-binding (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAACCTGTCACAATTTAGTGG	0.478000													8	47					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123357035	123357035	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:123357035G>A	ENST00000360772.3	-	30	5222	c.4844C>T	c.(4843-4845)gCg>gTg	p.A1615V	MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000475616.1_Missense_Mutation_p.A1615V|MYLK_ENST00000360304.3_Missense_Mutation_p.A1615V|MYLK_ENST00000359169.1_Missense_Mutation_p.A1615V|MYLK_ENST00000354792.5_Missense_Mutation_p.A415V|MYLK_ENST00000346322.5_Missense_Mutation_p.A1546V			Q15746	MYLK_HUMAN	myosin light chain kinase	1615	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGAGACCCCGCATTCTCTGA	0.552000													4	101					0	0	1	0	0
CDK17	5128	broad.mit.edu	37	12	96674555	96674555	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:96674555C>T	ENST00000543119.2	-	16	2088	c.1565G>A	c.(1564-1566)cGa>cAa	p.R522Q	CDK17_ENST00000542666.1_Missense_Mutation_p.R469Q|CDK17_ENST00000261211.3_Intron			Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	0							ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AATTCATGATCGACACGTGAA	0.348000													10	38					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57648307	57648307	+	Silent	SNP	A	A	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:57648307A>G	ENST00000269834.1	-	4	560	c.175T>C	c.(175-177)Ttg>Ctg	p.L59L		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCAACCTCAAGATCACATCG	0.517000													9	75					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149139	73149139	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:73149139C>T	ENST00000286657.4	-	22	3368	c.3332G>A	c.(3331-3333)gGt>gAt	p.G1111D		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	1111					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCATTTGGACCTCCCACTGA	0.468000													13	96					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37162988	37162988	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:37162988G>A	ENST00000421307.1	-	7	747	c.325C>T	c.(325-327)Cac>Tac	p.H109Y	LRRFIP2_ENST00000396428.2_Missense_Mutation_p.H92Y|LRRFIP2_ENST00000336686.4_Missense_Mutation_p.H109Y|LRRFIP2_ENST00000354379.4_Intron|LRRFIP2_ENST00000440230.1_Intron|LRRFIP2_ENST00000421276.2_Intron	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	109	DVL3-binding.				Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CCAACCCTGTGACTGCCAACA	0.358000													4	53					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42638408	42638408	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:42638408G>C	ENST00000372899.1	+	36	4299	c.4041G>C	c.(4039-4041)ttG>ttC	p.L1347F	UBR2_ENST00000372883.3_3'UTR|UBR2_ENST00000372901.1_Missense_Mutation_p.L1347F	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1347					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAAGAATTTTGAGTGATGAAG	0.308000													14	90					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767136	57767136	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr20:57767136G>A	ENST00000371030.2	+	1	1062	c.1062G>A	c.(1060-1062)gaG>gaA	p.E354E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	354						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACAGCGCGGAGCAGCCGCATG	0.756000													13	41					0	0	1	0	0
DUS2	54920	broad.mit.edu	37	16	68072007	68072007	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:68072007G>C	ENST00000565263.1	+	3	575	c.81G>C	c.(79-81)atG>atC	p.M27I	DUS2L_ENST00000432752.1_Missense_Mutation_p.M27I|DUS2L_ENST00000358896.6_Missense_Mutation_p.M27I	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN		27					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		CTCTTCCAATGAGGCTGCTGG	0.488000													8	117					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38828727	38828727	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:38828727C>T	ENST00000436693.2	-	2	2487	c.2368G>A	c.(2368-2370)Gaa>Aaa	p.E790K	TLR6_ENST00000381950.1_Missense_Mutation_p.E790K	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	790					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCATTGTTTTCAGTGACTAGT	0.363000													4	36					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1264910	1264910	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:1264910C>T	ENST00000447027.1	+	31	6867	c.6809C>T	c.(6808-6810)tCt>tTt	p.S2270F	MUC5B_ENST00000529681.1_Missense_Mutation_p.S2267F|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2267	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCACCCCCTTCTCCAGGGACG	0.672000													11	201					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206884551	206884551	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:206884551C>T	ENST00000403263.1	-	7	1721	c.1317G>A	c.(1315-1317)ctG>ctA	p.L439L		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	439					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						CCACCTCCCTCAGCTTGGTCC	0.423000													6	22					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94855306	94855306	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:94855306G>A	ENST00000289495.5	+	6	2140	c.1924G>A	c.(1924-1926)Gag>Aag	p.E642K	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.E642K|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.E642K|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.E642K|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.E642K|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.E664K	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	642	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAAGAAGATGAGGTAGGACC	0.473000										HNSCC(28;0.073)			4	111					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017087	1017087	+	Missense_Mutation	SNP	G	G	T	rs71472140		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:1017087G>T	ENST00000421673.2	-	31	5764	c.5714C>A	c.(5713-5715)tCc>tAc	p.S1905Y		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1905	Approximate repeats.|Thr-rich.			SP -> AA (in Ref. 5; AAA35866).	maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAGCTTGGGGATTGGCTGGT	0.552000													20	1105					3.27435e-08	3.67715e-08	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	47976658	47976658	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:47976658C>T	ENST00000543600.1	-	2	607	c.568G>A	c.(568-570)Gag>Aag	p.E190K	PTCHD4_ENST00000339488.4_Missense_Mutation_p.E207K			Q6ZW05	CF138_HUMAN	patched domain containing 4	207						integral to membrane	hedgehog receptor activity										TGATGCTCCTCCTGGAGCTTC	0.502000													11	50					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53645521	53645521	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:53645521C>G	ENST00000452676.2	-	5	989	c.563G>C	c.(562-564)aGc>aCc	p.S188T	ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.S188T|ZNF347_ENST00000334197.7_Missense_Mutation_p.S187T	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TGACTGAAGGCTTAATCCAAG	0.368000													15	132					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505570	159505570	+	Silent	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:159505570G>C	ENST00000334857.2	-	1	272	c.228C>G	c.(226-228)gtC>gtG	p.V76V		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					GTGGCACAATGACCAGTGTGT	0.433000													24	136					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133389906	133389906	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:133389906C>T	ENST00000204726.3	-	4	1064	c.506G>A	c.(505-507)cGc>cAc	p.R169H	GOLGA3_ENST00000545875.1_Missense_Mutation_p.R169H|GOLGA3_ENST00000456883.2_Missense_Mutation_p.R169H|GOLGA3_ENST00000537452.1_Missense_Mutation_p.R169H|GOLGA3_ENST00000450791.2_Missense_Mutation_p.R169H	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	169					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CTCCTGCTGGCGCTTCACCCT	0.587000													6	24					0	0	1	0	0
C9orf135	138255	broad.mit.edu	37	9	72501807	72501807	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:72501807C>A	ENST00000377197.3	+	5	590	c.503C>A	c.(502-504)cCa>cAa	p.P168Q	C9orf135_ENST00000466872.2_3'UTR|C9orf135_ENST00000527647.1_Intron	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	168						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						GATTATCAGCCACATGTGAGT	0.368000													11	58					1.58986e-06	1.75755e-06	1	1	0
COLEC10	10584	broad.mit.edu	37	8	120103455	120103455	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:120103455G>A	ENST00000332843.2	+	3	329	c.288G>A	c.(286-288)aaG>aaA	p.K96K	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	96	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			CCATTGGGAAGAAGGGTAAGT	0.438000													15	46					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115603908	115603908	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:115603908G>C	ENST00000361384.2	-	5	3391	c.2474C>G	c.(2473-2475)tCt>tGt	p.S825C	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.S825C	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	825					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		CGCAAGAAGAGAACGTTCCAT	0.453000								Other identified genes with known or suspected DNA repair function					4	90					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33716499	33716499	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:33716499G>A	ENST00000336934.5	-	4	451	c.335C>T	c.(334-336)aCg>aTg	p.T112M	STARD13_ENST00000399365.3_De_novo_Start_InFrame|STARD13_ENST00000255486.4_Missense_Mutation_p.T104M|STARD13_ENST00000487412.1_5'UTR	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	112	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CTTGTTCAACGTATTTAGTCG	0.358000													13	107					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946376	16946376	+	RNA	SNP	G	G	A	rs12086176		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:16946376G>A	ENST00000412962.1	-	0	1143																											GGAGGCCCTCGTCATGCTCCT	0.657000													6	32					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55540960	55540960	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:55540960T>C	ENST00000361760.1	+	1	47	c.47T>C	c.(46-48)cTc>cCc	p.L16P		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				ACTTTTATTCTCTTGGGTTTT	0.383000													6	222					0	0	1	0	0
JOSD2	126119	broad.mit.edu	37	19	51009451	51009451	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:51009451G>A	ENST00000598418.1	-	5	799	c.546C>T	c.(544-546)ggC>ggT	p.G182G	JOSD2_ENST00000595669.1_Silent_p.G140G|JOSD2_ENST00000391815.3_Silent_p.G182G|JOSD2_ENST00000601423.1_Silent_p.G182G	NM_001270639.1|NM_001270640.1	NP_001257568.1|NP_001257569.1	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	182	Josephin.				protein deubiquitination		ubiquitin-specific protease activity			kidney(1)|lung(3)|prostate(1)	5		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		GCAGCCAGCTGCCCTTCTCCT	0.677000													14	23					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31777941	31777941	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:31777941C>G	ENST00000375654.4	-	2	1998	c.1809G>C	c.(1807-1809)caG>caC	p.Q603H	HSPA1L_ENST00000417199.3_Missense_Mutation_p.Q603H	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	603					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GGTTACACATCTGCTCCAATT	0.483000													31	117					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114448933	114448933	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:114448933A>C	ENST00000297405.5	-	1	395	c.151T>G	c.(151-153)Ttt>Gtt	p.F51V	CSMD3_ENST00000455883.2_Missense_Mutation_p.F51V|CSMD3_ENST00000352409.3_Missense_Mutation_p.F51V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	51						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTCAATAAAAAGACGAGGTTC	0.507000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	260					0	0	1	0	0
NFIC	4782	broad.mit.edu	37	19	3452488	3452488	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:3452488C>T	ENST00000589123.1	+	8	1186	c.1066C>T	c.(1066-1068)Cgg>Tgg	p.R356W	NFIC_ENST00000590282.1_Missense_Mutation_p.R365W|NFIC_ENST00000443272.2_Missense_Mutation_p.R365W|NFIC_ENST00000395111.3_Missense_Mutation_p.R356W|NFIC_ENST00000341919.3_Missense_Mutation_p.R365W|NFIC_ENST00000346156.5_Missense_Mutation_p.R332W|NFIC_ENST00000586919.1_Missense_Mutation_p.R332W	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	365					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		AGGGATCGCCCGGAGCCCACA	0.647000													23	220					0	0	1	0	0
GMPR	2766	broad.mit.edu	37	6	16247130	16247130	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:16247130C>T	ENST00000259727.4	+	2	259	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S		NM_006877.3	NP_006868.3	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	49					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	20	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				CTCAGGGATTCCCATCATCGT	0.473000													17	95					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33648240	33648240	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:33648240C>G	ENST00000399362.4	-	16	1890	c.1537G>C	c.(1537-1539)Ggt>Cgt	p.G513R	CLASP2_ENST00000307312.7_Missense_Mutation_p.G2R|CLASP2_ENST00000487200.1_Missense_Mutation_p.G286R|CLASP2_ENST00000461133.3_Missense_Mutation_p.G280R|CLASP2_ENST00000313350.6_Missense_Mutation_p.G286R|CLASP2_ENST00000468888.2_Missense_Mutation_p.G514R|CLASP2_ENST00000480013.1_Missense_Mutation_p.G280R|CLASP2_ENST00000333778.6_Missense_Mutation_p.G290R|CLASP2_ENST00000539981.1_Missense_Mutation_p.G265R|CLASP2_ENST00000359576.5_Missense_Mutation_p.G513R	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	514										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TTTCTAAGACCCATGTATGTC	0.343000													7	94					0	0	1	0	0
TTLL4	9654	broad.mit.edu	37	2	219602570	219602570	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:219602570G>T	ENST00000392102.1	+	3	511	c.171G>T	c.(169-171)aaG>aaT	p.K57N	TTLL4_ENST00000457313.1_Intron|TTLL4_ENST00000442769.1_Missense_Mutation_p.K57N|TTLL4_ENST00000258398.4_Missense_Mutation_p.K57N	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	57					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AGCTGGAAAAGAAGCAAGTGG	0.582000													7	87					2.0095e-06	2.20422e-06	1	1	0
ATP2B3	492	broad.mit.edu	37	X	152823653	152823653	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:152823653C>T	ENST00000370186.1	+	15	2801	c.2475C>T	c.(2473-2475)gtC>gtT	p.V825V	ATP2B3_ENST00000370181.2_Silent_p.V825V|ATP2B3_ENST00000460549.1_3'UTR|ATP2B3_ENST00000393842.1_Silent_p.V825V|ATP2B3_ENST00000359149.3_Silent_p.V839V|ATP2B3_ENST00000263519.4_Silent_p.V839V|ATP2B3_ENST00000349466.2_Silent_p.V839V			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	839					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCAAGGCAGTCATGTGGGGCC	0.582000													17	130					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4871597	4871597	+	Splice_Site	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:4871597G>A	ENST00000321919.9	-	8	759	c.681_splice	c.e8-1	p.P228_splice	GLYR1_ENST00000381983.3_Intron|GLYR1_ENST00000436648.5_Splice_Site_p.P147_splice|GLYR1_ENST00000591451.1_Splice_Site_p.P228_splice	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	228					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						ACAGACAGCTGGCTAATGAAG	0.443000													11	95					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79048590	79048590	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr5:79048590A>G	ENST00000446378.2	+	6	11114	c.11083A>G	c.(11083-11085)Agt>Ggt	p.S3695G		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3695						perinuclear region of cytoplasm		p.S3695R(2)		NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTCGGCAAGAAGTGACCAGAT	0.383000													13	66					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8608483	8608483	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:8608483G>T	ENST00000382480.2	+	6	1315	c.515G>T	c.(514-516)tGg>tTg	p.W172L	CPZ_ENST00000360986.4_Missense_Mutation_p.W309L|CPZ_ENST00000315782.6_Missense_Mutation_p.W298L|CPZ_ENST00000429646.2_5'UTR	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	309					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TACAACGGGTGGACGAGCGGG	0.657000													8	59					0.0581538	0.0587768	1	1	0
DRAM2	128338	broad.mit.edu	37	1	111662502	111662502	+	Missense_Mutation	SNP	G	G	T	rs78046136		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:111662502G>T	ENST00000286692.4	-	7	1214	c.597C>A	c.(595-597)gaC>gaA	p.D199E	DRAM2_ENST00000484310.1_5'UTR|DRAM2_ENST00000539140.1_Missense_Mutation_p.D199E			Q6UX65	DRAM2_HUMAN	DNA-damage regulated autophagy modulator 2	199					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane				endometrium(1)|large_intestine(5)|lung(3)	9						TTCTTACTTTGTCCTCGGGGT	0.333000													6	63					0.00116845	0.0012247	1	1	0
COL6A1	1291	broad.mit.edu	37	21	47423881	47423881	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr21:47423881G>A	ENST00000361866.3	+	35	3155	c.3041G>A	c.(3040-3042)cGc>cAc	p.R1014H	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	1014	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCCCTGCTCCGCGGTGTCTTC	0.677000													6	86					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70775082	70775082	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:70775082T>G	ENST00000373719.3	+	7	988	c.771T>G	c.(769-771)aaT>aaG	p.N257K	OGT_ENST00000373701.3_Missense_Mutation_p.N247K	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	257					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					TGAGTCCAAATCACGCAGTGG	0.483000													14	58					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42866710	42866710	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:42866710G>T	ENST00000334370.4	+	33	6453	c.5818G>T	c.(5818-5820)Gag>Tag	p.E1940*	MEGF8_ENST00000251268.6_Nonsense_Mutation_p.E2007*	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2007	PSI 5.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTGCACGCGGGAGGGCAAGTG	0.632000													14	139					2.35188e-11	2.69467e-11	1	1	0
CFB	629	broad.mit.edu	37	6	31905149	31905149	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:31905149C>G	ENST00000456570.1	+	5	638	c.583C>G	c.(583-585)Ctc>Gtc	p.L195V	C2_ENST00000299367.5_Missense_Mutation_p.L348V|C2_ENST00000442278.2_Missense_Mutation_p.L216V|CFB_ENST00000477310.1_Missense_Mutation_p.L166V|CFB_ENST00000556679.1_Missense_Mutation_p.L195V|C2_ENST00000469372.1_Missense_Mutation_p.L102V|C2_ENST00000452323.2_Missense_Mutation_p.L134V			P00751	CFAB_HUMAN	complement factor B	364	Sushi 3.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CAGTGTCTATCTCATGATGAA	0.473000													11	155					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26204762	26204762	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:26204762C>G	ENST00000264712.3	-	1	604	c.25G>C	c.(25-27)Gag>Cag	p.E9Q	KIF3C_ENST00000405914.1_Missense_Mutation_p.E9Q	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	9	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGAGGGCCTCGCTGGCCTTG	0.667000													6	64					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482036	76482036	+	Silent	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:76482036C>G	ENST00000307431.8	+	6	1048	c.663C>G	c.(661-663)ctC>ctG	p.L221L	CNTNAP4_ENST00000478060.1_Silent_p.L197L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Silent_p.L221L|CNTNAP4_ENST00000476707.1_Silent_p.L225L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	222	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGATTCTACTCCACAGGGAAG	0.378000													9	61					0	0	1	0	0
ZNF85	7639	broad.mit.edu	37	19	21131726	21131726	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:21131726C>G	ENST00000601023.1	+	2	875	c.229C>G	c.(229-231)Caa>Gaa	p.Q77E	ZNF85_ENST00000345030.6_Missense_Mutation_p.Q103E|ZNF85_ENST00000328178.8_Missense_Mutation_p.Q136E			Q03923	ZNF85_HUMAN	zinc finger protein 85	136						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						TGGACTTAACCAATGTCTCAC	0.328000													4	112					0	0	1	0	0
YY2	404281	broad.mit.edu	37	X	21874755	21874755	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:21874755C>T	ENST00000429584.2	+	1	651	c.153C>T	c.(151-153)taC>taT	p.Y51Y	MBTPS2_ENST00000365779.2_Intron|MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000465888.1_3'UTR	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	51	Mediates transcriptional activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						ATTGGATCTACGGTGGCCACA	0.537000													4	121					0	0	1	0	0
GPR160	26996	broad.mit.edu	37	3	169801763	169801763	+	Translation_Start_Site	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:169801763G>A	ENST00000355897.5	+	4	611	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_014373.2	NP_055188.1	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	1						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)	8	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			CTAAAAATATGACTGCTCTCT	0.358000													5	115					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8239028	8239028	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:8239028G>A	ENST00000520004.1	-	2	494	c.230C>T	c.(229-231)tCa>tTa	p.S77L	SGK223_ENST00000330777.4_Missense_Mutation_p.S77L			Q86YV5	SG223_HUMAN		77							ATP binding|non-membrane spanning protein tyrosine kinase activity										GGAGTAAGGTGAGCTGTTCAC	0.647000													13	64					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249485	119249485	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:119249485C>T	ENST00000217999.2	-	1	362	c.288G>A	c.(286-288)ccG>ccA	p.P96P	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	96					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						TCTCGGGCTGCGGACCCTCCA	0.662000													4	96					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178681637	178681637	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:178681637G>A	ENST00000286063.5	-	9	1973	c.1656C>T	c.(1654-1656)atC>atT	p.I552I	PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Silent_p.I194I|PDE11A_ENST00000409504.1_Silent_p.I194I|PDE11A_ENST00000358450.4_Silent_p.I302I|PDE11A_ENST00000389683.3_Silent_p.I108I	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	552	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding	p.I552I(1)|p.I302I(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GTCCACAAAAGATGACAAAAG	0.423000									Primary Pigmented Nodular Adrenocortical Disease, Familial				7	74					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19683938	19683938	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:19683938G>A	ENST00000395544.4	-	25	3262	c.2763C>T	c.(2761-2763)gtC>gtT	p.V921V	ULK2_ENST00000361658.2_Silent_p.V921V	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	921					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TCAGATTCTTGACAACTGAAA	0.338000													5	47					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113358346	113358346	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:113358346A>C	ENST00000297405.5	-	41	6666	c.6422T>G	c.(6421-6423)aTa>aGa	p.I2141R	CSMD3_ENST00000343508.3_Missense_Mutation_p.I2101R|CSMD3_ENST00000455883.2_Missense_Mutation_p.I2037R|CSMD3_ENST00000352409.3_Missense_Mutation_p.I2071R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2141	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGGTAGATTTATTGTCCATGT	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			35	246					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96771954	96771954	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:96771954G>A	ENST00000359933.4	-	31	5598	c.4705C>T	c.(4705-4707)Cct>Tct	p.P1569S	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1569										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAAGTGGGAGGGACTATTCCA	0.378000													10	50					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7021955	7021955	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:7021955T>C	ENST00000278314.4	-	3	1274	c.959A>G	c.(958-960)aAt>aGt	p.N320S	ZNF214_ENST00000536068.1_Missense_Mutation_p.N320S	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TCTTTGATGATTGTGAAGACT	0.398000													14	131					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63994239	63994239	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:63994239G>A	ENST00000279206.3	+	2	271	c.115G>A	c.(115-117)Gag>Aag	p.E39K	NUDT22_ENST00000441250.2_Missense_Mutation_p.E39K	NM_001128612.2|NM_032344.2	NP_001122084.1|NP_115720.1	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 22	39							hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						AGGTGGGGACGAGGCCATCAC	0.687000													10	68					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20101734	20101734	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:20101734G>C	ENST00000396085.1	+	25	5665	c.5304G>C	c.(5302-5304)aaG>aaC	p.K1768N	NAV2_ENST00000349880.4_Missense_Mutation_p.K1768N|NAV2_ENST00000360655.4_Missense_Mutation_p.K1704N|NAV2_ENST00000396087.3_Missense_Mutation_p.K1824N|NAV2_ENST00000533917.1_Missense_Mutation_p.K832N|NAV2_ENST00000527559.2_Missense_Mutation_p.K1753N|NAV2_ENST00000311043.8_Missense_Mutation_p.K832N|NAV2_ENST00000540292.1_Missense_Mutation_p.K1755N	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1824						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GTGACTCAAAGAAGAAGAAGC	0.567000													4	23					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57918797	57918797	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:57918797C>T	ENST00000355673.3	+	5	634	c.278C>T	c.(277-279)tCa>tTa	p.S93L	MBD6_ENST00000431731.2_Missense_Mutation_p.S93L	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	93						chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						GGGCCAGCATCAGAGGAGGAC	0.597000													15	139					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53400278	53400278	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:53400278C>T	ENST00000262056.9	+	1	337	c.11C>T	c.(10-12)tCa>tTa	p.S4L	EIF4B_ENST00000551527.1_3'UTR|EIF4B_ENST00000420463.3_Missense_Mutation_p.S4L|EIF4B_ENST00000416762.3_Missense_Mutation_p.S4L	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	4					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						ATGGCGGCCTCAGGTGAGCGA	0.612000													15	135					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177908869	177908869	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:177908869G>A	ENST00000308284.6	-	18	2260	c.2171C>T	c.(2170-2172)tCa>tTa	p.S724L	RP4-798P15.3_ENST00000528461.1_3'UTR|RP4-798P15.3_ENST00000354921.2_5'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	724					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CGAAATATCTGAGCGAGTAGG	0.408000													4	13					0	0	1	0	0
IDH3B	3420	broad.mit.edu	37	20	2639112	2639112	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr20:2639112G>A	ENST00000380851.5	-	12	1158	c.1128C>T	c.(1126-1128)gtC>gtT	p.V376V	IDH3B_ENST00000488299.1_5'UTR|IDH3B_ENST00000380843.4_3'UTR	NM_001258384.1|NM_174855.2	NP_001245313.1|NP_777280.1	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3 (NAD+) beta	376					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding			breast(1)|endometrium(3)|kidney(2)|lung(7)|prostate(1)	14					NADH(DB00157)	AGGCAGCAATGACAGCCTCAG	0.493000													3	24					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96091445	96091445	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:96091445C>T	ENST00000453304.1	-	15	2838	c.2490G>A	c.(2488-2490)gcG>gcA	p.A830A		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	830					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGATGGTGTTCGCAGGATCCA	0.552000													23	190					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	100015808	100015808	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:100015808C>G	ENST00000289371.5	+	24	3796	c.3594C>G	c.(3592-3594)ttC>ttG	p.F1198L		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	1198					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAGACTGGTTCAGAGATGAAA	0.433000													6	83					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115603955	115603955	+	Silent	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:115603955G>C	ENST00000361384.2	-	5	3344	c.2427C>G	c.(2425-2427)gtC>gtG	p.V809V	DCLRE1A_ENST00000369305.1_Silent_p.V809V	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	809					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGTGTAATATGACAGTACCAT	0.443000								Other identified genes with known or suspected DNA repair function					6	79					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27601563	27601563	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:27601563G>A	ENST00000323703.6	-	3	768	c.570C>T	c.(568-570)ctC>ctT	p.L190L	ZNF513_ENST00000491924.1_Intron|ZNF513_ENST00000407879.1_Silent_p.L128L	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	190					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAGGTTGACGAGCTGGGCTG	0.657000													7	58					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31071207	31071207	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:31071207G>A	ENST00000206595.6	+	10	1034	c.880G>A	c.(880-882)Gag>Aag	p.E294K	G2E3_ENST00000438909.2_Missense_Mutation_p.E248K|G2E3_ENST00000544007.1_3'UTR|G2E3_ENST00000553504.1_Missense_Mutation_p.E324K	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	294					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						ATCTGTAGGAGAGTTCCAAAA	0.284000													5	46					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144732950	144732950	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:144732950G>A	ENST00000501748.2	+	1	997	c.908G>A	c.(907-909)cGc>cAc	p.R303H	ZNF623_ENST00000458270.2_Missense_Mutation_p.R263H|ZNF623_ENST00000526926.1_Missense_Mutation_p.R263H	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTCCGTCATCGCTCAGACCTT	0.448000													11	94					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39806526	39806526	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:39806526G>A	ENST00000564288.1	+	40	11259	c.10482G>A	c.(10480-10482)ctG>ctA	p.L3494L	MACF1_ENST00000567887.1_Silent_p.L3531L|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000372915.3_Silent_p.L3499L|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000289893.4_Silent_p.L1934L|MACF1_ENST00000545844.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3499					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTCAAGATCTGAGAGCCTGGG	0.418000													7	65					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20460094	20460094	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr22:20460094C>G	ENST00000426804.1	-	1	1692	c.1208G>C	c.(1207-1209)cGt>cCt	p.R403P		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			GCAGCCTGCACGCCGCAGCTG	0.667000													5	47					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47456604	47456604	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:47456604G>A	ENST00000265565.5	-	19	3535	c.3123C>T	c.(3121-3123)agC>agT	p.S1041S	SCAP_ENST00000441517.2_Silent_p.S785S|SCAP_ENST00000545718.1_Silent_p.S648S	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	1041	Interaction with SREBF2 (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		ACTGCAGGGGGCTGAGGGCAG	0.597000													3	34					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985295	6985295	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr18:6985295C>T	ENST00000389658.3	-	39	5694	c.5601G>A	c.(5599-5601)ctG>ctA	p.L1867L		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1867	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTGTAGACCAGGTCGACTG	0.502000													25	199					0	0	1	0	0
ZNF213	7760	broad.mit.edu	37	16	3187479	3187479	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:3187479C>T	ENST00000396878.3	+	2	673	c.198C>T	c.(196-198)ctC>ctT	p.L66L	ZNF213_ENST00000416391.2_5'UTR|ZNF213_ENST00000574902.1_Silent_p.L66L|ZNF213_ENST00000576416.1_Silent_p.L66L	NM_001134655.1|NM_004220.2	NP_001128127.1|NP_004211.1	O14771	ZN213_HUMAN	zinc finger protein 213	66	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	16						TCAGCCAGCTCTGGGAGCTCT	0.652000													9	100					0	0	1	0	0
RASSF5	83593	broad.mit.edu	37	1	206760287	206760287	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:206760287G>C	ENST00000304534.8	+	5	1184	c.775G>C	c.(775-777)Gaa>Caa	p.E259Q	RASSF5_ENST00000355294.4_Missense_Mutation_p.E412Q|RASSF5_ENST00000338603.2_Intron|RASSF5_ENST00000491368.1_3'UTR|EIF2D_ENST00000472709.2_Intron|RASSF5_ENST00000367117.3_3'UTR	NM_182665.2	NP_872606.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	412					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGCCTTAAGAGAATCCCAGGG	0.413000													7	54					0	0	1	0	0
IRF5	3663	broad.mit.edu	37	7	128582205	128582205	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:128582205C>A	ENST00000402030.2	+	2	142	c.70C>A	c.(70-72)Cag>Aag	p.Q24K	IRF5_ENST00000477535.1_Missense_Mutation_p.Q24K|IRF5_ENST00000473745.1_Missense_Mutation_p.Q24K|IRF5_ENST00000249375.4_Missense_Mutation_p.Q24K|IRF5_ENST00000357234.5_Missense_Mutation_p.Q24K	NM_001098629.1|NM_001098630.1	NP_001092099.1|NP_001092100.1	Q13568	IRF5_HUMAN	interferon regulatory factor 5	24					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|prostate(1)	15						GCTGGTGGCCCAGGTGAACAG	0.622000													14	57					2.32078e-09	2.63768e-09	1	1	0
CERS4	79603	broad.mit.edu	37	19	8321959	8321959	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:8321959G>A	ENST00000558331.1	+	9	1045	c.586G>A	c.(586-588)Gag>Aag	p.E196K	CERS4_ENST00000595722.1_3'UTR|CERS4_ENST00000559336.1_Missense_Mutation_p.E247K|CERS4_ENST00000559450.1_Missense_Mutation_p.E247K|CERS4_ENST00000251363.5_Missense_Mutation_p.E247K			Q9HA82	CERS4_HUMAN	ceramide synthase 4	247	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CTACCTGCTGGAGGTGGGCCC	0.612000													20	188					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72022728	72022728	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:72022728C>T	ENST00000378743.3	-	20	4274	c.3916G>A	c.(3916-3918)Gag>Aag	p.E1306K		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1306					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GACTGTTCCTCATCACTACTG	0.328000													11	88					0	0	1	0	0
HDAC8	55869	broad.mit.edu	37	X	71792516	71792516	+	Silent	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:71792516G>T	ENST00000439122.2	-	1	382	c.96C>A	c.(94-96)gcC>gcA	p.A32A	HDAC8_ENST00000373573.3_Silent_p.A32A|HDAC8_ENST00000373583.1_Silent_p.A32A|HDAC8_ENST00000373589.4_Silent_p.A32A|HDAC8_ENST00000373554.1_Silent_p.A32A|HDAC8_ENST00000373561.4_Silent_p.A32A|HDAC8_ENST00000478743.1_5'UTR|HDAC8_ENST00000373560.2_Silent_p.A32A|HDAC8_ENST00000373556.3_Silent_p.A32A|HDAC8_ENST00000373571.1_Silent_p.A32A|HDAC8_ENST00000373559.4_Silent_p.A32A|HDAC8_ENST00000429103.2_5'UTR	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	32	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	TGGGGATCTTGGCCAGGGAGT	0.592000													10	82					5.50884e-06	5.99616e-06	1	1	0
CCNI	10983	broad.mit.edu	37	4	77979787	77979787	+	Splice_Site	SNP	T	T	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:77979787T>A	ENST00000237654.4	-	3	692	c.114_splice	c.e3-1	p.N39_splice	CCNI_ENST00000504697.1_5'UTR|CCNI_ENST00000537948.1_Splice_Site_p.N25_splice	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	39					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						TGGAGAAACATTCTATAAGGG	0.363000													16	107					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155051	12155051	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:12155051G>C	ENST00000602107.1	-	5	1305	c.1306C>G	c.(1306-1308)Cac>Gac	p.H436D	CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.H389D|CTD-2006C1.2_ENST00000591838.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TCTCCAGTGTGAGTCCTTTCA	0.428000													7	81					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4924259	4924259	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:4924259G>A	ENST00000396658.4	+	14	2551	c.1848G>A	c.(1846-1848)caG>caA	p.Q616Q	UBN1_ENST00000262376.6_Silent_p.Q616Q|UBN1_ENST00000590769.1_Silent_p.Q616Q|UBN1_ENST00000545171.1_Silent_p.Q616Q	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	616					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						CATCAGGACAGATTGGTGGCC	0.507000													22	250					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765413	47765413	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:47765413G>C	ENST00000273857.4	-	4	599	c.600C>G	c.(598-600)atC>atG	p.I200M	CORIN_ENST00000502252.1_Missense_Mutation_p.I133M|CORIN_ENST00000504584.1_Missense_Mutation_p.I200M|CORIN_ENST00000505909.1_Missense_Mutation_p.I200M|CORIN_ENST00000508498.1_Missense_Mutation_p.I61M	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	200	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CGCCATCAATGATGCACTCAG	0.408000													3	32					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47889778	47889778	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:47889778C>T	ENST00000446256.2	+	16	2850	c.2278C>T	c.(2278-2280)Cgg>Tgg	p.R760W	DHX30_ENST00000457607.1_Missense_Mutation_p.R827W|DHX30_ENST00000445061.1_Missense_Mutation_p.R799W|DHX30_ENST00000348968.4_Missense_Mutation_p.R771W	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	799	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCCTCGAAGCCGGCTGGAGAA	0.597000													4	51					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76726448	76726448	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:76726448G>C	ENST00000538159.1	+	20	2308	c.2308G>C	c.(2308-2310)Gaa>Caa	p.E770Q	USO1_ENST00000514213.2_Missense_Mutation_p.E746Q			O60763	USO1_HUMAN	USO1 vesicle transport factor	761					intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTCTATGATTGAAAATATGGT	0.338000													3	31					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367739	57367739	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:57367739G>A	ENST00000403558.1	+	2	907	c.541G>A	c.(541-543)Gta>Ata	p.V181I	SERPING1_ENST00000378324.2_Missense_Mutation_p.V95I|SERPING1_ENST00000340687.6_Missense_Mutation_p.V147I|SERPING1_ENST00000278407.4_Missense_Mutation_p.V147I|SERPING1_ENST00000378323.4_Missense_Mutation_p.V152I	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	147					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						GGATGCTTTGGTAGATTTCTC	0.542000													31	155					0	0	1	0	0
LZTFL1	54585	broad.mit.edu	37	3	45872573	45872573	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:45872573C>T	ENST00000296135.6	-	6	688	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	LZTFL1_ENST00000539217.1_Missense_Mutation_p.E168K|LZTFL1_ENST00000536047.1_Missense_Mutation_p.E155K|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	172										endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		ACCTGTATTTCAATGGTCTTC	0.279000													6	32					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135080595	135080595	+	Nonsense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:135080595G>C	ENST00000428680.2	-	9	1190	c.911C>G	c.(910-912)tCa>tGa	p.S304*	CNOT4_ENST00000541284.1_Nonsense_Mutation_p.S307*|CNOT4_ENST00000315544.5_Nonsense_Mutation_p.S307*|CNOT4_ENST00000414802.1_Nonsense_Mutation_p.S307*|CNOT4_ENST00000451834.1_Nonsense_Mutation_p.S304*|CNOT4_ENST00000361528.4_Nonsense_Mutation_p.S304*|CNOT4_ENST00000423368.2_Nonsense_Mutation_p.S307*|CNOT4_ENST00000356162.4_Nonsense_Mutation_p.S307*	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	307					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						ATTGGATTTTGACAAACCAGG	0.388000													21	41					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103137151	103137151	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:103137151G>A	ENST00000424685.2	-	56	9174	c.9015C>T	c.(9013-9015)taC>taT	p.Y3005Y	RELN_ENST00000343529.5_Silent_p.Y3005Y|RELN_ENST00000428762.1_Silent_p.Y3005Y|CTB-107G13.1_ENST00000422488.1_RNA			P78509	RELN_HUMAN	reelin	3005					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAGAAGTATGTAGTCGTGTC	0.428000													5	96					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113259262	113259262	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:113259262C>T	ENST00000297405.5	-	64	10453	c.10209G>A	c.(10207-10209)caG>caA	p.Q3403Q	CSMD3_ENST00000343508.3_Silent_p.Q3363Q|CSMD3_ENST00000455883.2_Silent_p.Q3234Q|CSMD3_ENST00000352409.3_Silent_p.Q3333Q	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3403	Sushi 27.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGCATTCAGGCTGAATCCCAC	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	42					0	0	1	0	0
AVPR1A	552	broad.mit.edu	37	12	63541270	63541270	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:63541270C>G	ENST00000299178.2	-	2	1231	c.1126G>C	c.(1126-1128)Gaa>Caa	p.E376Q		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	376					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TCAGTATCTTCTTTGTTGAAT	0.403000													21	130					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49064276	49064276	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:49064276G>C	ENST00000326739.4	-	7	702	c.663C>G	c.(661-663)atC>atG	p.I221M		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	221	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	TCCGGGCAATGATGGCCACAA	0.527000													15	163					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069412	57069412	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:57069412G>A	ENST00000532437.1	-	8	5151	c.4840C>T	c.(4840-4842)Cgg>Tgg	p.R1614W	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.R1614W			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1614	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CGAGATGCCCGTGGCTCTGCA	0.587000													4	69					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30361940	30361940	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:30361940G>A	ENST00000327564.7	+	6	2130	c.2069G>A	c.(2068-2070)cGc>cAc	p.R690H	LRRC37B_ENST00000394713.3_Missense_Mutation_p.R612H|LRRC37B_ENST00000341671.7_Missense_Mutation_p.R663H|LRRC37B_ENST00000543378.2_Missense_Mutation_p.R581H|LRRC37B_ENST00000584368.1_Missense_Mutation_p.R624H			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	663						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ATTCTCAATCGCAATCCTCTG	0.323000													4	84					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26294277	26294277	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr22:26294277G>T	ENST00000335473.7	+	29	4922	c.4672G>T	c.(4672-4674)Ggg>Tgg	p.G1558W	CTA-125H2.2_ENST00000594856.1_RNA|CTA-125H2.2_ENST00000594585.1_RNA|CTA-125H2.2_ENST00000600903.1_RNA|CTA-125H2.2_ENST00000595102.1_RNA|CTA-125H2.2_ENST00000597548.1_RNA|CTA-125H2.2_ENST00000453457.2_RNA|CTA-125H2.2_ENST00000597284.1_RNA|CTA-125H2.2_ENST00000599080.1_RNA|MYO18B_ENST00000407587.2_Missense_Mutation_p.G1559W|CTA-125H2.2_ENST00000600211.1_RNA|MYO18B_ENST00000536101.1_Missense_Mutation_p.G1558W|CTA-125H2.2_ENST00000599792.1_RNA|CTA-125H2.2_ENST00000600269.1_RNA|CTA-125H2.2_ENST00000594542.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1558	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTTACAGCTTGGGGAGTTGCA	0.468000													5	63					0.217242	0.218013	1	1	0
CSTF2T	23283	broad.mit.edu	37	10	53459276	53459276	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:53459276C>A	ENST00000331173.4	-	1	79	c.34G>T	c.(34-36)Gat>Tat	p.D12Y	PRKG1_ENST00000373985.1_Intron|PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	12					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		AGTGATCGATCCATTGCCGGG	0.522000													14	168					3.32936e-07	3.70948e-07	1	1	0
YKT6	10652	broad.mit.edu	37	7	44251862	44251862	+	Nonsense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:44251862C>G	ENST00000223369.2	+	7	665	c.578C>G	c.(577-579)tCa>tGa	p.S193*	YKT6_ENST00000447123.1_3'UTR|YKT6_ENST00000496112.1_Nonsense_Mutation_p.S159*	NM_006555.3	NP_006546.1	O15498	YKT6_HUMAN	YKT6 v-SNARE homolog (S. cerevisiae)	193	v-SNARE coiled-coil homology.				ER to Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi|vesicle docking involved in exocytosis|vesicle targeting	cytoplasmic vesicle membrane|cytosol|endoplasmic reticulum|endosome|Golgi membrane|integral to plasma membrane|mitochondrion|SNARE complex	protein-cysteine S-palmitoleyltransferase activity|SNAP receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7						AAACAAAACTCATGCTGTGCC	0.542000													15	249					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2831387	2831387	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:2831387G>A	ENST00000356331.5	+	8	1015	c.754G>A	c.(754-756)Gag>Aag	p.E252K	SH3BP2_ENST00000511747.1_Missense_Mutation_p.E252K|SH3BP2_ENST00000452765.2_Missense_Mutation_p.E252K|SH3BP2_ENST00000435136.2_Missense_Mutation_p.E252K|SH3BP2_ENST00000442312.2_Missense_Mutation_p.E280K|SH3BP2_ENST00000503393.2_Missense_Mutation_p.E309K|SH3BP2_ENST00000515183.1_3'UTR	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	252					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CCTGGCTGCTGAGGACTCCAA	0.677000									Cherubism				6	49					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186971086	186971086	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:186971086T>G	ENST00000337774.5	-	6	1151	c.762A>C	c.(760-762)aaA>aaC	p.K254N	MASP1_ENST00000296280.6_Missense_Mutation_p.K254N|MASP1_ENST00000169293.6_Missense_Mutation_p.K254N|MASP1_ENST00000495249.1_Intron|MASP1_ENST00000392470.2_Missense_Mutation_p.K228N|MASP1_ENST00000392472.2_Missense_Mutation_p.K141N	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	254	CUB 2.|Interaction with FCN2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity	p.K254N(2)|p.K254K(2)		NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GCCCCAAAACTTTTGGACCAA	0.498000													21	230					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116048543	116048543	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:116048543G>A	ENST00000374199.4	+	8	1182	c.781G>A	c.(781-783)Gat>Aat	p.D261N	PRPF4_ENST00000374198.4_Missense_Mutation_p.D262N			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	262						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						GTCTGTTCCTGATTGCAACCT	0.443000													12	143					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122625503	122625503	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:122625503C>T	ENST00000319080.6	+	16	2643	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F	MLXIP_ENST00000538698.1_Silent_p.F444F			Q9HAP2	MLXIP_HUMAN	MLX interacting protein	837	Mediates heterotypic interactions between MLXIP and MLX and is required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		CACTGCAGTTCAGCATCATCA	0.607000													18	79					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138820219	138820219	+	Silent	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:138820219G>C	ENST00000370557.1	-	28	4162	c.3135C>G	c.(3133-3135)ctC>ctG	p.L1045L	ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370543.1_Silent_p.L1051L|ATP11C_ENST00000327569.3_Silent_p.L1051L|ATP11C_ENST00000361648.2_Silent_p.L1051L|ATP11C_ENST00000359686.2_Silent_p.L1051L			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	1051					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TCTGTTGCTTGAGAAAAGGCC	0.333000													4	77					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835662	247835662	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:247835662C>T	ENST00000359688.2	-	1	703	c.682G>A	c.(682-684)Gta>Ata	p.V228I	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTGCCTTCTACTGTGCGGATA	0.453000													9	91					0	0	1	0	0
ADIG	149685	broad.mit.edu	37	20	37214687	37214687	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr20:37214687A>T	ENST00000537425.1	+	2	196	c.125A>T	c.(124-126)gAc>gTc	p.D42V		NM_001018082.1	NP_001018092.1	Q0VDE8	ADIG_HUMAN	adipogenin	47					brown fat cell differentiation|positive regulation of fat cell differentiation|white fat cell differentiation	cytoplasm|integral to membrane|nucleus				endometrium(1)|kidney(1)	2		Myeloproliferative disorder(115;0.00878)				GAGGAAAATGACTCCAGTGTG	0.587000													6	15					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370086	36370086	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:36370086G>C	ENST00000221891.4	+	16	2016	c.1824G>C	c.(1822-1824)aaG>aaC	p.K608N	APLP1_ENST00000586861.1_Missense_Mutation_p.K601N|APLP1_ENST00000537454.2_Missense_Mutation_p.K568N	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	607					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCAGGAAGAAGCCCTACGGGG	0.652000													5	79					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986156	61986156	+	Silent	SNP	A	A	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:61986156A>G	ENST00000409186.1	-	5	4181	c.2076T>C	c.(2074-2076)ggT>ggC	p.G692G	PCDH20_ENST00000409204.4_Silent_p.G692G			Q8N6Y1	PCD20_HUMAN	protocadherin 20	665	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCCTCAGCATACCCTTTCCTG	0.488000													24	79					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56504321	56504321	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:56504321T>C	ENST00000370754.5	-	20	2686	c.2687A>G	c.(2686-2688)aAa>aGa	p.K896R	DST_ENST00000370765.6_Missense_Mutation_p.K392R|DST_ENST00000312431.6_Missense_Mutation_p.K718R|DST_ENST00000370769.4_Missense_Mutation_p.K718R|DST_ENST00000361203.3_Missense_Mutation_p.K718R|DST_ENST00000370788.2_Missense_Mutation_p.K718R|DST_ENST00000518935.1_Missense_Mutation_p.K392R|DST_ENST00000421834.2_Missense_Mutation_p.K718R|DST_ENST00000446842.2_Missense_Mutation_p.K392R|DST_ENST00000244364.6_Missense_Mutation_p.K392R			Q03001	DYST_HUMAN	dystonin	718	SH3.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTCCTCTTCTTTTTCATTCAA	0.378000													39	116					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76872081	76872081	+	Splice_Site	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:76872081C>A	ENST00000373344.5	-	22	5780	c.5566_splice	c.e22+1	p.G1856_splice	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Splice_Site_p.G1818_splice	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1856					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TATTGTTTACCTGTTAAGTGA	0.323000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						19	231					5.26018e-13	6.05134e-13	1	1	0
C7orf63	79846	broad.mit.edu	37	7	89891339	89891339	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:89891339G>A	ENST00000389297.4	+	4	576	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	C7orf63_ENST00000316089.8_Missense_Mutation_p.E109K|C7orf63_ENST00000463311.1_3'UTR|C7orf63_ENST00000497910.1_Missense_Mutation_p.E109K	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	109							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						TCGTTTTATAGAATCTGCATA	0.264000													8	143					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88307720	88307720	+	Missense_Mutation	SNP	T	T	C	rs145337179	byFrequency	TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:88307720T>C	ENST00000357081.3	-	3	185	c.41A>G	c.(40-42)aAt>aGt	p.N14S	AGTPBP1_ENST00000376083.3_Missense_Mutation_p.N14S|AGTPBP1_ENST00000376081.4_Missense_Mutation_p.N14S|AGTPBP1_ENST00000337006.4_5'UTR|AGTPBP1_ENST00000376109.3_Missense_Mutation_p.N66S			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	14					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						CCTAGAATTATTGGTAAGGCT	0.363000													10	45					0	0	1	0	0
TM6SF2	53345	broad.mit.edu	37	19	19377413	19377413	+	Silent	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:19377413C>G	ENST00000389363.4	-	9	882	c.810G>C	c.(808-810)ctG>ctC	p.L270L	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	270						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			ACATGTACATCAGCATCTGCA	0.607000													5	23					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33015613	33015613	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:33015613C>G	ENST00000280979.4	+	4	1924	c.1754C>G	c.(1753-1755)tCt>tGt	p.S585C	AKAP6_ENST00000557272.1_Missense_Mutation_p.S585C|AKAP6_ENST00000557354.1_Missense_Mutation_p.S585C	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	585					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGTGAATCCTCTGTTGGCTCA	0.448000													21	99					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35243359	35243359	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:35243359G>C	ENST00000378495.3	+	6	688	c.466G>C	c.(466-468)Gag>Cag	p.E156Q	UNC13B_ENST00000396787.1_Missense_Mutation_p.E156Q|UNC13B_ENST00000378496.4_Missense_Mutation_p.E156Q	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	156					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGACAATGAGGTAGGAGC	0.448000													10	81					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66467891	66467891	+	Silent	SNP	G	G	A	rs55882537		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:66467891G>A	ENST00000273854.3	-	3	978	c.378C>T	c.(376-378)atC>atT	p.I126I	EPHA5_ENST00000432638.2_Silent_p.I126I|EPHA5_ENST00000511294.1_Silent_p.I126I|EPHA5_ENST00000354839.4_Silent_p.I126I	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	126					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GTTCTATGAAGATTCTGGAAG	0.438000										TSP Lung(17;0.13)			8	127					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21422676	21422676	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr18:21422676G>A	ENST00000313654.9	+	29	3806	c.3565G>A	c.(3565-3567)Gca>Aca	p.A1189T	LAMA3_ENST00000399516.3_Missense_Mutation_p.A1189T	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1189	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAAGTGGCCGCAACTGTGAA	0.547000													15	94					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118363941	118363941	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:118363941C>G	ENST00000534358.1	+	16	5197	c.5174C>G	c.(5173-5175)tCt>tGt	p.S1725C	KMT2A_ENST00000354520.4_Missense_Mutation_p.S1684C|KMT2A_ENST00000389506.5_Missense_Mutation_p.S1722C	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AATTACACATCTGTGGTATGT	0.413000													10	84					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210012466	210012466	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:210012466C>G	ENST00000491415.2	+	7	1332	c.1275C>G	c.(1273-1275)ttC>ttG	p.F425L		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	425					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						ATGACCACTTCAGGATTGGTA	0.438000													14	42					0	0	1	0	0
IL1R1	3554	broad.mit.edu	37	2	102785104	102785104	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:102785104G>C	ENST00000410023.1	+	7	1020	c.702G>C	c.(700-702)gaG>gaC	p.E234D	IL1R1_ENST00000409589.1_Intron|IL1R1_ENST00000409288.1_Missense_Mutation_p.E234D|IL1R1_ENST00000409329.1_Missense_Mutation_p.E234D|IL1R1_ENST00000424272.1_Missense_Mutation_p.E234D|IL1R1_ENST00000233946.3_Missense_Mutation_p.E234D|IL1R1_ENST00000409929.1_Missense_Mutation_p.E234D			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	234	Ig-like C2-type 3.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	CAGCTAATGAGACAATGGAAG	0.373000													15	125					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414440	29414440	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:29414440G>A	ENST00000378993.1	+	4	1101	c.428G>A	c.(427-429)tGc>tAc	p.C143Y	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.C143Y	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	143	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						ACTGGACTCTGCTATAATTCC	0.388000													7	101					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48613940	48613940	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:48613940G>T	ENST00000268933.3	+	2	602	c.23G>T	c.(22-24)cGc>cTc	p.R8L	EPN3_ENST00000537145.1_Silent_p.A90A|EPN3_ENST00000541226.1_5'UTR	NM_017957.2	NP_060427.2	Q9H201	EPN3_HUMAN	epsin 3	8						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			GCACTCCGGCGCCAGGTGAAG	0.657000													4	69					0.000602214	0.000633556	1	1	0
RELN	5649	broad.mit.edu	37	7	103251214	103251214	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:103251214G>A	ENST00000428762.1	-	22	3095	c.2936C>T	c.(2935-2937)tCa>tTa	p.S979L	RELN_ENST00000424685.2_Missense_Mutation_p.S979L|RELN_ENST00000343529.5_Missense_Mutation_p.S979L	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	979					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATACTTGCTGATGTAAATTC	0.418000													15	254					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36162722	36162722	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:36162722T>A	ENST00000378660.1	+	11	1493	c.1305T>A	c.(1303-1305)agT>agA	p.S435R	CHDC2_ENST00000313548.4_Missense_Mutation_p.S435R					calponin homology domain containing 2																		caggagtcagtggcctgagaa	0.488000													6	49					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049930	94049930	+	Silent	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:94049930C>A	ENST00000297268.6	+	37	2736	c.2265C>A	c.(2263-2265)ccC>ccA	p.P755P		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	755			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTGTTGGTCCCACAGGCCCCG	0.498000										HNSCC(75;0.22)			5	25					0.014758	0.0150777	1	1	0
PSG6	5675	broad.mit.edu	37	19	43420318	43420318	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:43420318C>A	ENST00000601833.1	-	2	1456	c.173G>T	c.(172-174)gGg>gTg	p.G58V	PSG6_ENST00000187910.2_Missense_Mutation_p.G129V|PSG6_ENST00000292125.2_Missense_Mutation_p.G129V|PSG6_ENST00000402603.4_Missense_Mutation_p.G129V					pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				TCCTCCAGTCCCATCGCCTCG	0.493000													26	129					9.86323e-18	1.14397e-17	1	1	0
CDK15	65061	broad.mit.edu	37	2	202677239	202677239	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:202677239C>T	ENST00000450471.2	+	4	488	c.402C>T	c.(400-402)atC>atT	p.I134I	CDK15_ENST00000434439.1_Silent_p.I134I|CDK15_ENST00000488419.1_3'UTR|CDK15_ENST00000260967.2_Silent_p.I83I|CDK15_ENST00000374598.4_Silent_p.I134I|CDK15_ENST00000410091.3_Silent_p.I83I	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	134	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	TAAAAGTCATCAGCATGAATG	0.413000													11	146					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722214	196722214	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:196722214G>A	ENST00000312428.6	-	44	8401	c.8301C>T	c.(8299-8301)atC>atT	p.I2767I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2767	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTTTTCTTATGATATTCATAT	0.393000													4	80					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292770	102292770	+	RNA	SNP	C	C	T	rs149751844	by1000genomes	TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr15:102292770C>T	ENST00000561463.1	+	0	816																											AGCGGCGCGACGAGATGCTGC	0.597000													6	35					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481238	140481238	+	Silent	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr5:140481238C>A	ENST00000231130.2	+	1	1005	c.1005C>A	c.(1003-1005)gtC>gtA	p.V335V	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		335	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGTCATAGTCCAGGTGGTTG	0.463000													5	73					2.0095e-06	2.20422e-06	1	1	0
CPSF7	79869	broad.mit.edu	37	11	61183152	61183152	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:61183152G>C	ENST00000340437.4	-	7	1279	c.1199C>G	c.(1198-1200)tCt>tGt	p.S400C	CPSF7_ENST00000448745.1_Missense_Mutation_p.S348C|CPSF7_ENST00000439958.3_Missense_Mutation_p.S348C|CPSF7_ENST00000394888.4_Missense_Mutation_p.S357C	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	357					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						ACTGGCTCCAGATACTGCTTT	0.443000													6	74					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52758751	52758751	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:52758751C>A	ENST00000257901.3	-	2	699	c.624G>T	c.(622-624)aaG>aaT	p.K208N		NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	208	Coil 1B.|Rod.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CTCACTTCTTCTTGTAGCCCT	0.607000													7	132					0.00198382	0.00206405	1	1	0
LMF2	91289	broad.mit.edu	37	22	50943396	50943396	+	Silent	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr22:50943396C>A	ENST00000216080.5	-	10	1365	c.1197G>T	c.(1195-1197)gtG>gtT	p.V399V	LMF2_ENST00000380796.3_Intron|LMF2_ENST00000474879.2_Silent_p.V424V			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	424						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCCGGGCTCCACGTAGGAGT	0.692000													4	11					0.00024832	0.00026419	1	1	0
ABT1	29777	broad.mit.edu	37	6	26597380	26597380	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:26597380T>A	ENST00000274849.1	+	1	201	c.170T>A	c.(169-171)tTc>tAc	p.F57Y		NM_013375.3	NP_037507.1	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	57	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11						CCGCCGCGCTTCCGGCCCCTG	0.622000													4	31					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72134001	72134001	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:72134001G>A	ENST00000305425.4	-	5	1814	c.1392C>T	c.(1390-1392)agC>agT	p.S464S	DACH1_ENST00000354591.4_Intron|DACH1_ENST00000359684.2_Silent_p.S516S|DACH1_ENST00000313174.7_Intron	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	514					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGGACACGCTGCTGCTGCGAT	0.547000													8	26					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20101610	20101610	+	Splice_Site	SNP	G	G	T	rs143296630	byFrequency	TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:20101610G>T	ENST00000396085.1	+	25	5541	c.5179_splice	c.e25-1	p.G1727_splice	NAV2_ENST00000349880.4_Splice_Site_p.G1727_splice|NAV2_ENST00000360655.4_Splice_Site_p.G1663_splice|NAV2_ENST00000396087.3_Splice_Site_p.G1783_splice|NAV2_ENST00000533917.1_Splice_Site_p.G791_splice|NAV2_ENST00000527559.2_Splice_Site_p.G1712_splice|NAV2_ENST00000311043.8_Splice_Site_p.G791_splice|NAV2_ENST00000540292.1_Splice_Site_p.G1714_splice	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1783						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TGGTCTCCAGGAAACGGCACT	0.577000													7	46					8.12818e-05	8.7463e-05	1	1	0
UCP3	7352	broad.mit.edu	37	11	73716916	73716916	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:73716916C>A	ENST00000314032.4	-	4	952	c.400G>T	c.(400-402)Gcc>Tcc	p.A134S	UCP3_ENST00000348534.4_Intron|UCP3_ENST00000426995.2_Missense_Mutation_p.A134S	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	134					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					GTGGGCTGGGCACAGGTCACC	0.612000													7	59					0.0293803	0.0298016	1	1	0
COG7	91949	broad.mit.edu	37	16	23436185	23436185	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:23436185G>A	ENST00000307149.5	-	7	1079	c.894C>T	c.(892-894)ctC>ctT	p.L298L		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	298					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		CGCCGTTGCTGAGGCAGGAGG	0.647000													9	71					0	0	1	0	0
RP11-383M4.6	0	broad.mit.edu	37	9	84547870	84547870	+	RNA	SNP	T	T	C	rs138226188	by1000genomes	TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:84547870T>C	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CGTGAACCCATAGAAATCTTC	0.428000													3	10					0	0	1	0	0
LECT2	3950	broad.mit.edu	37	5	135286949	135286949	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr5:135286949C>G	ENST00000274507.1	-	3	452	c.252G>C	c.(250-252)aaG>aaC	p.K84N	LECT2_ENST00000512872.1_Missense_Mutation_p.K12N|FBXL21_ENST00000467490.1_RNA|LECT2_ENST00000514447.2_Missense_Mutation_p.K84N|LECT2_ENST00000522943.1_Missense_Mutation_p.K84N|LECT2_ENST00000471827.1_5'UTR	NM_002302.2	NP_002293.2	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2	84					chemotaxis|skeletal system development	cytoplasm|extracellular space				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGATAGCATTCTTGTTTTGAT	0.463000													8	55					0	0	1	0	0
RTKN	6242	broad.mit.edu	37	2	74654356	74654356	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:74654356G>C	ENST00000305557.5	-	12	1846	c.1261C>G	c.(1261-1263)Cct>Gct	p.P421A	RTKN_ENST00000272430.5_Missense_Mutation_p.P434A|RTKN_ENST00000233330.6_Missense_Mutation_p.P384A	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	434					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						CGGGGAGCAGGAGTTTCAATT	0.502000													7	86					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49067981	49067981	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:49067981G>C	ENST00000395443.2	-	10	2707	c.2235C>G	c.(2233-2235)atC>atG	p.I745M	QRICH1_ENST00000357496.2_Missense_Mutation_p.I745M|QRICH1_ENST00000424300.1_Missense_Mutation_p.I745M	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	745										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GCTCTCTGCTGATAGGCTGGA	0.547000													3	64					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425789	57425789	+	Silent	SNP	T	T	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:57425789T>C	ENST00000371237.4	-	2	219	c.153A>G	c.(151-153)agA>agG	p.R51R	C8B_ENST00000494324.1_5'UTR|C8B_ENST00000535057.1_5'UTR|C8B_ENST00000543257.1_5'UTR	NM_000066.2	NP_000057.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	51					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TCCGCATCTGTCTGCTCTTAG	0.463000													4	73					0	0	1	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159618	242159618	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:242159618C>T	ENST00000357246.3	-	4	355	c.291G>A	c.(289-291)atG>atA	p.M97I		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	97					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGGTTGCGCTCATGCTGACCA	0.562000													16	151					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36766906	36766906	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:36766906G>A	ENST00000399881.3	+	21	2221	c.2184G>A	c.(2182-2184)ccG>ccA	p.P728P		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	728	Segment S9.					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.P728P(5)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCAGCCCCGATGGGGCTTC	0.468000													12	538					0	0	1	0	0
OR5M11	219487	broad.mit.edu	37	11	56310057	56310057	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:56310057C>T	ENST00000528616.2	-	1	700	c.677G>A	c.(676-678)cGg>cAg	p.R226Q		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						TGATTTGATCCGGAGGATGGC	0.493000													9	62					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31318539	31318539	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr18:31318539G>T	ENST00000269197.5	+	11	1171	c.1171G>T	c.(1171-1173)Ggc>Tgc	p.G391C		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TGGGACTTCTGGCCTTCCAGT	0.498000													4	34					0.00024832	0.00026419	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76486617	76486617	+	Silent	SNP	T	T	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:76486617T>A	ENST00000307431.8	+	9	1666	c.1281T>A	c.(1279-1281)ctT>ctA	p.L427L	CNTNAP4_ENST00000478060.1_Silent_p.L355L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Silent_p.L379L|CNTNAP4_ENST00000476707.1_Silent_p.L431L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	428	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						ATGGAAAACTTAAGTCGAATC	0.418000													5	53					0	0	1	0	0
GSDMD	79792	broad.mit.edu	37	8	144643207	144643207	+	Silent	SNP	G	G	A	rs145648319		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:144643207G>A	ENST00000526406.1	+	8	1498	c.615G>A	c.(613-615)acG>acA	p.T205T	GSDMD_ENST00000533063.1_Silent_p.T253T|GSDMD_ENST00000262580.4_Silent_p.T205T	NM_001166237.1	NP_001159709.1	P57764	GSDMD_HUMAN	gasdermin D	205										breast(1)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	12						AGAAGAAGACGGTCACCATCC	0.687000													9	41					0	0	1	0	0
CAPN12	147968	broad.mit.edu	37	19	39221800	39221800	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:39221800C>T	ENST00000328867.4	-	19	2329	c.2021G>A	c.(2020-2022)cGt>cAt	p.R674H	CAPN12_ENST00000601953.1_Missense_Mutation_p.R525H|ACTN4_ENST00000252699.2_3'UTR	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	674	Domain IV.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GAAGTCCACACGCAGACGGCT	0.647000													3	38					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135038267	135038267	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:135038267G>A	ENST00000304613.3	+	30	5144	c.5123G>A	c.(5122-5124)cGc>cAc	p.R1708H	KNDC1_ENST00000368572.2_Missense_Mutation_p.R1710H			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1708	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction			p.R1708H(1)		NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGGATTGCCCGCTTCAGCGGT	0.587000													8	38					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92436038	92436038	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:92436038C>T	ENST00000267622.4	-	21	6292	c.5919G>A	c.(5917-5919)ctG>ctA	p.L1973L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1973					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		AAAGGTCTTTCAGCACAACCC	0.438000			T	PDGFRB	AML								11	95					0	0	1	0	0
CALM3	808	broad.mit.edu	37	19	47111501	47111501	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:47111501A>G	ENST00000291295.9	+	3	281	c.82A>G	c.(82-84)Atc>Gtc	p.I28V	CALM3_ENST00000596362.1_Missense_Mutation_p.I28V|CALM3_ENST00000598871.1_5'UTR|CALM3_ENST00000599839.1_5'UTR|CALM3_ENST00000477244.1_3'UTR|CALM3_ENST00000597743.1_Missense_Mutation_p.I28V|CALM3_ENST00000391918.2_5'UTR|CALM3_ENST00000594523.1_5'UTR	NM_005184.2	NP_005175.2	P62158	CALM_HUMAN	calmodulin 3 (phosphorylase kinase, delta)	28	EF-hand 1.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			breast(1)|cervix(2)|endometrium(1)|lung(1)|ovary(1)	6		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000683)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0341)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	AGATGGCACTATCACCACCAA	0.537000													22	73					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129518519	129518519	+	Silent	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:129518519G>C	ENST00000276218.2	-	1	992	c.903C>G	c.(901-903)ctC>ctG	p.L301L		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	301						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						GGAATGAGGTGAGCACCTTCT	0.552000													7	85					0	0	1	0	0
RNF34	80196	broad.mit.edu	37	12	121837952	121837952	+	Translation_Start_Site	SNP	T	T	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:121837952T>A	ENST00000361234.5	+	0	109				RNF34_ENST00000392464.2_De_novo_Start_InFrame|RNF34_ENST00000392465.3_De_novo_Start_InFrame|RNF34_ENST00000555076.1_De_novo_Start_InFrame	NM_025126.3	NP_079402.2	Q969K3	RNF34_HUMAN	ring finger protein 34, E3 ubiquitin protein ligase						apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding			breast(1)|large_intestine(1)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		AGGTCGGCAGTGTGAGGAGCT	0.701000													3	7					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645124	52645124	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr20:52645124G>T	ENST00000395961.3	-	4	696	c.530C>A	c.(529-531)aCa>aAa	p.T177K	BCAS1_ENST00000411563.1_Missense_Mutation_p.T80K|BCAS1_ENST00000371435.2_Missense_Mutation_p.T177K|BCAS1_ENST00000371440.3_Missense_Mutation_p.T177K	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	177						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TGCTCCCCCTGTCTCAGGTGG	0.602000													8	148					5.18039e-06	5.66043e-06	1	1	0
RLTPR	146206	broad.mit.edu	37	16	67684046	67684046	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:67684046C>T	ENST00000334583.6	+	22	2505	c.2177C>T	c.(2176-2178)tCa>tTa	p.S726L	RLTPR_ENST00000545661.1_Missense_Mutation_p.S690L	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	726										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TCAGACCCCTCAGAGCAGGTC	0.602000													5	11					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102826059	102826059	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:102826059C>G	ENST00000260302.3	-	2	312	c.284G>C	c.(283-285)aGa>aCa	p.R95T	MMP13_ENST00000340273.4_Missense_Mutation_p.R95T	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	95					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AACCCCGCATCTTGGCTTTTT	0.428000													21	132					0	0	1	0	0
C11orf72	100505621	broad.mit.edu	37	11	67372240	67372240	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:67372240G>A	ENST00000333139.3	-	3	541	c.301C>T	c.(301-303)Caa>Taa	p.Q101*	C11orf72_ENST00000446232.1_Nonsense_Mutation_p.Q101*			Q8NBR9	CK072_HUMAN	chromosome 11 open reading frame 72	101										central_nervous_system(1)|lung(2)|stomach(1)	4						aggtaaagttgaccagataga	0.542000													6	31					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55429793	55429793	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:55429793G>C	ENST00000360586.3	-	19	2473	c.2408C>G	c.(2407-2409)tCt>tGt	p.S803C	WDHD1_ENST00000420358.2_Missense_Mutation_p.S680C|WDHD1_ENST00000359167.4_Missense_Mutation_p.S321C|WDHD1_ENST00000421192.1_Missense_Mutation_p.S680C	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	803						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						TAATTTCCGAGAGCGAGAAGC	0.418000													12	59					0	0	1	0	0
ICT1	3396	broad.mit.edu	37	17	73016661	73016661	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:73016661G>A	ENST00000301585.5	+	5	458	c.445G>A	c.(445-447)Gat>Aat	p.D149N		NM_001545.1	NP_001536.1	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1	149					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)|urinary_tract(1)	6	all_lung(278;0.226)					GAATCTGGCAGATTGCCTGCA	0.453000													6	64					0	0	1	0	0
ERLIN2	11160	broad.mit.edu	37	8	37607144	37607144	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:37607144C>T	ENST00000276461.5	+	7	559	c.492C>T	c.(490-492)gtC>gtT	p.V164V	ERLIN2_ENST00000519638.1_Silent_p.V164V	NM_007175.6	NP_009106.1	O94905	ERLN2_HUMAN	ER lipid raft associated 2	164					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding			NS(1)|large_intestine(1)|lung(5)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CTGGGCTGGTCATTCAAGTAA	0.488000													65	198					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2921635	2921635	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr18:2921635C>T	ENST00000261596.4	-	18	2576	c.2338G>A	c.(2338-2340)Gaa>Aaa	p.E780K		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	780	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGTTTCTTTTCTATCACTTCT	0.398000													12	48					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66384409	66384409	+	Silent	SNP	A	A	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:66384409A>C	ENST00000329654.4	+	3	359	c.172A>C	c.(172-174)Aga>Cga	p.R58R	PDE4B_ENST00000371049.3_Silent_p.R58R	NM_001037341.1	NP_001032418.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	58					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	ACTGTCTCAAAGACAGAGTGA	0.483000													7	60					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179989910	179989910	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:179989910G>A	ENST00000367607.3	+	12	3419	c.3001G>A	c.(3001-3003)Gat>Aat	p.D1001N		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1001						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						GGGAGACCAGGATGGACAGCC	0.408000													9	104					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20682903	20682903	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:20682903G>A	ENST00000404938.2	+	6	1063	c.411G>A	c.(409-411)aaG>aaA	p.K137K		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	321	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GACAGACCAAGAGGATTCGAA	0.423000													4	47					0	0	1	0	0
ESD	2098	broad.mit.edu	37	13	47354167	47354167	+	Splice_Site	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:47354167G>A	ENST00000378720.3	-	8	685	c.501_splice	c.e8-1	p.S168_splice	ESD_ENST00000495654.1_5'UTR|ESD_ENST00000378697.1_Splice_Site_p.S139_splice	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	168						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	TGCTGACACAGACTTCAGAAA	0.318000													25	94					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172046834	172046834	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:172046834C>A	ENST00000336824.4	+	12	1446	c.1347C>A	c.(1345-1347)ttC>ttA	p.F449L	FNDC3B_ENST00000416957.1_Missense_Mutation_p.F449L|FNDC3B_ENST00000415807.2_Missense_Mutation_p.F449L	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	449	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GGTACACATTCAGGCTGGCCG	0.483000													5	174					0.000602214	0.000633556	1	1	0
SLC30A6	55676	broad.mit.edu	37	2	32434586	32434586	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:32434586G>A	ENST00000282587.5	+	13	878	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	SLC30A6_ENST00000435660.1_Intron|SLC30A6_ENST00000406369.1_Missense_Mutation_p.E207K|SLC30A6_ENST00000379343.2_Missense_Mutation_p.E321K|SLC30A6_ENST00000357055.3_Missense_Mutation_p.E84K|SLC30A6_ENST00000538303.1_Missense_Mutation_p.E252K	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	281						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGGAGTTTTAGAAGTCCGAAA	0.328000													14	129					0	0	1	0	0
POLA1	5422	broad.mit.edu	37	X	24844702	24844702	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:24844702C>T	ENST00000379068.3	+	32	3763	c.3720C>T	c.(3718-3720)ctC>ctT	p.L1240L	POLA1_ENST00000379059.3_Silent_p.L1234L			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	1234					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	ATGCTGTCCTCATTGCAACGT	0.493000													3	30					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75839860	75839860	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:75839860G>C	ENST00000322507.8	-	37	6466	c.6157C>G	c.(6157-6159)Cag>Gag	p.Q2053E	COL12A1_ENST00000345356.6_Missense_Mutation_p.Q889E|COL12A1_ENST00000483888.2_Missense_Mutation_p.Q2053E|COL12A1_ENST00000416123.2_Missense_Mutation_p.Q2053E	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2053	Fibronectin type-III 16.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CTGTACTGCTGAACTGGCCCA	0.423000													6	68					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208458	58208458	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:58208458C>T	ENST00000377918.3	+	1	1804	c.1778C>T	c.(1777-1779)gCg>gTg	p.A593V		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	593	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AACGACACCGCGGAGCTGCAG	0.657000													7	48					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	647878	647878	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:647878G>C	ENST00000255622.6	+	5	905	c.862G>C	c.(862-864)Gac>Cac	p.D288H	RP11-1191J2.2_ENST00000489312.1_RNA|PDE6B_ENST00000496514.1_Missense_Mutation_p.D288H|RP11-1191J2.2_ENST00000468356.1_RNA|PDE6B_ENST00000429163.2_Missense_Mutation_p.D9H	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	288	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GGAATTTTTTGACGTGTGGTC	0.667000													6	75					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24720071	24720071	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:24720071G>A	ENST00000396475.2	+	12	1677	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	MPP6_ENST00000222644.4_Missense_Mutation_p.E460K|MPP6_ENST00000409761.1_Missense_Mutation_p.E348K	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	460	Guanylate kinase-like.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						TGCGGCTCCGGAGCTAGAGAC	0.413000													21	110					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15325940	15325940	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:15325940C>A	ENST00000378116.4	-	2	268	c.262G>T	c.(262-264)Gtc>Ttc	p.V88F		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	88						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GAGGCGGTGACAATCAACTGA	0.542000													12	75					1.49906e-05	1.62542e-05	1	1	0
FLNC	2318	broad.mit.edu	37	7	128489448	128489448	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:128489448C>A	ENST00000325888.8	+	30	5276	c.5015C>A	c.(5014-5016)gCa>gAa	p.A1672E	FLNC_ENST00000346177.6_Missense_Mutation_p.A1672E	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1672					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GATGCCAAGGCAGCCGGTGAG	0.617000													5	47					0.0215528	0.0219404	1	1	0
ZNF10	7556	broad.mit.edu	37	12	133727683	133727683	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:133727683C>T	ENST00000248211.6	+	3	325	c.103C>T	c.(103-105)Cag>Tag	p.Q35*	ZNF268_ENST00000416488.1_Nonsense_Mutation_p.Q35*|CTD-2140B24.4_ENST00000540096.2_Nonsense_Mutation_p.Q35*|ZNF10_ENST00000426665.2_Nonsense_Mutation_p.Q35*|ZNF10_ENST00000402932.2_Nonsense_Mutation_p.Q35*|ZNF10_ENST00000540927.1_3'UTR	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GGACACTGCTCAGCAGATCGT	0.443000													16	90					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66276608	66276608	+	Missense_Mutation	SNP	C	C	G	rs139936930		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:66276608C>G	ENST00000532677.1	+	18	2558	c.2157C>G	c.(2155-2157)ttC>ttG	p.F719L	DPP3_ENST00000530165.1_Missense_Mutation_p.F670L|DPP3_ENST00000531863.1_Missense_Mutation_p.F720L|CTD-3074O7.11_ENST00000419755.3_5'UTR|DPP3_ENST00000360510.2_Missense_Mutation_p.F700L|DPP3_ENST00000541961.1_Missense_Mutation_p.F700L|DPP3_ENST00000453114.1_Missense_Mutation_p.F700L	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	700					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity	p.F700F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TCCGATCCTTCTCTGAGCGTT	0.592000													9	53					0	0	1	0	0
NAE1	8883	broad.mit.edu	37	16	66847750	66847750	+	Splice_Site	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:66847750C>A	ENST00000379463.2	-	13	1015		c.e13-1		NAE1_ENST00000394074.2_Splice_Site|NAE1_ENST00000359087.4_Splice_Site|NAE1_ENST00000290810.3_Splice_Site	NM_001018159.1	NP_001018169.1	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1						apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TGCTTGGGATCTAACAAAGGA	0.303000													4	70					1	1	1	1	0
UBE2D4	51619	broad.mit.edu	37	7	43992254	43992254	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:43992254A>T	ENST00000222402.2	+	7	493	c.404A>T	c.(403-405)aAc>aTc	p.N135I	UBE2D4_ENST00000394798.4_Missense_Mutation_p.N97I|POLR2J4_ENST00000427076.1_RNA	NM_015983.3	NP_057067.1	Q9Y2X8	UB2D4_HUMAN	ubiquitin-conjugating enzyme E2D 4 (putative)	135					protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|large_intestine(2)|lung(1)|pancreas(1)	5						TCCAGGTACAACAGACTAGCA	0.463000													5	156					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35393642	35393642	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:35393642A>T	ENST00000311565.4	+	9	1461	c.1112A>T	c.(1111-1113)gAg>gTg	p.E371V	PPARD_ENST00000448077.2_Missense_Mutation_p.E332V|PPARD_ENST00000418635.2_Missense_Mutation_p.E273V|PPARD_ENST00000360694.3_Missense_Mutation_p.E371V|PPARD_ENST00000540939.1_Missense_Mutation_p.E268V	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	371	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CCACGGGTGGAGGCTATCCAG	0.622000													8	64					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86794265	86794265	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:86794265C>G	ENST00000394703.5	+	5	571	c.8C>G	c.(7-9)aCa>aGa	p.T3R	DMTF1_ENST00000413276.2_Missense_Mutation_p.T3R|DMTF1_ENST00000414194.2_5'UTR|DMTF1_ENST00000432937.2_Intron|DMTF1_ENST00000331242.7_Missense_Mutation_p.T3R|DMTF1_ENST00000411766.2_Missense_Mutation_p.T3R|DMTF1_ENST00000394702.3_Missense_Mutation_p.T3R	NM_021145.3	NP_066968.3	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	3	Interaction with CCND2 (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					AGTATGAGCACAGTGGAAGAG	0.393000													8	118					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49088077	49088077	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:49088077G>T	ENST00000261900.3	-	9	1142	c.920C>A	c.(919-921)aCa>aAa	p.T307K		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	307					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CACTGCACTTGTGGTAGAAGT	0.488000													7	79					0.000157383	0.00016871	1	1	0
LHFPL5	222662	broad.mit.edu	37	6	35773541	35773541	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:35773541C>G	ENST00000360215.1	+	1	471	c.94C>G	c.(94-96)Ctc>Gtc	p.L32V	LHFPL5_ENST00000373853.1_Missense_Mutation_p.L32V	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	32						integral to membrane				endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						GTGGGGTACCCTCACCATCTG	0.592000													31	111					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251898	98251898	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:98251898C>G	ENST00000284311.3	+	1	1156	c.1021C>G	c.(1021-1023)Ctc>Gtc	p.L341V		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	341						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CACTAAGGCTCTCTCCACCTT	0.488000													16	67					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063268	9063268	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:9063268C>T	ENST00000397910.4	-	3	24381	c.24178G>A	c.(24178-24180)Gat>Aat	p.D8060N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8062	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCCCACATCGGTCACTGTT	0.463000													25	91					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71444826	71444826	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr14:71444826C>A	ENST00000304743.2	+	6	2218	c.1772C>A	c.(1771-1773)cCa>cAa	p.P591Q	PCNX_ENST00000238570.5_Missense_Mutation_p.P591Q|PCNX_ENST00000439984.3_Missense_Mutation_p.P591Q	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	591						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGTACCAAGCCACACAGTGCT	0.468000													14	114					7.93312e-07	8.80421e-07	1	1	0
FBXO30	84085	broad.mit.edu	37	6	146126695	146126695	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:146126695G>C	ENST00000237281.4	-	2	1013	c.847C>G	c.(847-849)Ctt>Gtt	p.L283V		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	283							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		CCATTACAAAGAGCAGAAGTG	0.338000													4	178					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201400850	201400850	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:201400850G>A	ENST00000357799.4	+	4	470	c.372G>A	c.(370-372)atG>atA	p.M124I	SGOL2_ENST00000469840.1_3'UTR|SGOL2_ENST00000409203.3_Missense_Mutation_p.M124I	NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	124					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						CAATTGAAATGAGCAGTCTTT	0.308000													25	150					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087130	100087130	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:100087130G>C	ENST00000423930.1	+	4	1945	c.1786G>C	c.(1786-1788)Gat>Cat	p.D596H	NYAP1_ENST00000454988.1_Missense_Mutation_p.D539H|NYAP1_ENST00000300179.2_Missense_Mutation_p.D596H			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	596																	GCAAGGGACCGATGGGGGTGC	0.637000													5	137					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63576113	63576113	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:63576113C>T	ENST00000374852.3	-	3	320	c.253G>A	c.(253-255)Gat>Aat	p.D85N	MTMR8_ENST00000453546.1_Missense_Mutation_p.D85N	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	85						nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AGGTCAGAATCTAAAACAAAG	0.428000													4	39					0	0	1	0	0
SCGB1D4	404552	broad.mit.edu	37	11	62065028	62065028	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:62065028G>T	ENST00000358585.1	-	2	211	c.158C>A	c.(157-159)cCa>cAa	p.P53Q		NM_206998.1	NP_996881.1	Q6XE38	SG1D4_HUMAN	secretoglobin, family 1D, member 4	53						extracellular region	binding			lung(1)|prostate(1)	2						AAGAGCTTCTGGAGGTGGATT	0.443000													24	234					1.10923e-09	1.26578e-09	1	1	0
DAZAP1	26528	broad.mit.edu	37	19	1422393	1422393	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:1422393G>A	ENST00000336761.6	+	6	666	c.461G>A	c.(460-462)cGa>cAa	p.R154Q	DAZAP1_ENST00000586579.1_3'UTR|DAZAP1_ENST00000233078.4_Missense_Mutation_p.R154Q	NM_170711.1	NP_733829.1	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	154	RRM 2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAGGCCCCGAGGTAAGGGC	0.612000													11	107					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9801975	9801975	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:9801975G>C	ENST00000256190.8	-	40	5677	c.5540C>G	c.(5539-5541)tCt>tGt	p.S1847C	SBF2-AS1_ENST00000499953.2_RNA|SBF2-AS1_ENST00000534671.1_RNA|SBF2-AS1_ENST00000527406.1_RNA|SBF2-AS1_ENST00000498905.2_RNA|SBF2-AS1_ENST00000525636.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1847	PH.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCAGGCATCAGAGATACAACT	0.478000													6	42					0	0	1	0	0
CDK6	1021	broad.mit.edu	37	7	92355095	92355095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:92355095G>A	ENST00000265734.4	-	4	793	c.382C>T	c.(382-384)Cag>Tag	p.Q128*	CDK6_ENST00000424848.2_Nonsense_Mutation_p.Q128*	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	128	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CGGAGAAGCTGAAACATCATA	0.403000			T	MLLT10	ALL								7	188					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57133846	57133846	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:57133846C>T	ENST00000328070.6	+	3	1425	c.1191C>T	c.(1189-1191)ctC>ctT	p.L397L		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	397						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCTCGTCCCTCATCGTGCACC	0.637000													6	82					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	31012227	31012227	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:31012227A>G	ENST00000298139.5	+	32	4024	c.3775A>G	c.(3775-3777)Atg>Gtg	p.M1259V		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1259					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTCACAGTCTATGGCCATCAC	0.338000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				5	74					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103205798	103205798	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:103205798C>T	ENST00000428762.1	-	34	5296	c.5137G>A	c.(5137-5139)Gaa>Aaa	p.E1713K	RELN_ENST00000424685.2_Missense_Mutation_p.E1713K|RELN_ENST00000343529.5_Missense_Mutation_p.E1713K	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1713					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTGAACTTTCCGTGTAATGC	0.468000													25	80					0	0	1	0	0
WBP1	23559	broad.mit.edu	37	2	74687518	74687518	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:74687518G>A	ENST00000393972.3	+	5	825	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	WBP1_ENST00000233615.2_Missense_Mutation_p.E174K|WBP1_ENST00000409737.1_Missense_Mutation_p.E171K|WBP1_ENST00000494741.1_3'UTR			Q96G27	WBP1_HUMAN	WW domain binding protein 1	174							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						AACAAATGTGGAAGGTGTTTC	0.627000													14	155					0	0	1	0	0
RNF2	6045	broad.mit.edu	37	1	185062311	185062311	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:185062311C>A	ENST00000367510.3	+	4	655	c.367C>A	c.(367-369)Cat>Aat	p.H123N	RNF2_ENST00000367509.4_Intron	NM_007212.3	NP_009143.1	Q99496	RING2_HUMAN	ring finger protein 2	123	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(3)|endometrium(2)|large_intestine(4)|lung(3)|skin(2)	14		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GTATGAAGCTCATCAAGAGAG	0.423000													5	70					0.014758	0.0150777	1	1	0
VWA1	64856	broad.mit.edu	37	1	1372561	1372561	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:1372561G>A	ENST00000476993.1	+	2	406	c.328G>A	c.(328-330)Gac>Aac	p.D110N	VWA1_ENST00000338660.5_Intron|VWA1_ENST00000404702.3_Intron	NM_022834.4	NP_073745.2	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	110	VWFA.					basement membrane				NS(1)|breast(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCGCATGGGTGACACCCACAC	0.652000													3	17					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32136680	32136680	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:32136680C>T	ENST00000312561.4	+	4	3205	c.2791C>T	c.(2791-2793)Cag>Tag	p.Q931*	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		TCTACCCAATCAGCAAGGGAT	0.388000													16	79					0	0	1	0	0
FAM50A	9130	broad.mit.edu	37	X	153674848	153674848	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:153674848G>C	ENST00000393600.3	+	4	492	c.382G>C	c.(382-384)Gaa>Caa	p.E128Q		NM_004699.3	NP_004690.1	Q14320	FA50A_HUMAN	family with sequence similarity 50, member A	128					spermatogenesis	nucleus				breast(2)|central_nervous_system(1)|lung(9)|ovary(2)|skin(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ggaggaggaagaagagggagg	0.607000													3	30					0	0	1	0	0
PLCD3	113026	broad.mit.edu	37	17	43195405	43195405	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:43195405G>C	ENST00000322765.5	-	7	1329	c.1216C>G	c.(1216-1218)Ctc>Gtc	p.L406V	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	406	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	TCCCGGAAGAGAATCTTGGAG	0.662000													5	17					0	0	1	0	0
PGA5	5222	broad.mit.edu	37	11	61015925	61015925	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:61015925G>A	ENST00000312403.5	+	6	876	c.691G>A	c.(691-693)Ggc>Agc	p.G231S	PGA5_ENST00000451616.2_Missense_Mutation_p.G77S|CTD-2331C18.5_ENST00000537594.1_RNA|PGA4_ENST00000422676.2_Missense_Mutation_p.G231S	NM_014224.2	NP_055039.1	P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	231					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						GATCTTTGGTGGCATTGACTC	0.498000													57	314					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208204977	208204977	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:208204977C>A	ENST00000367033.3	-	29	5940	c.5183G>T	c.(5182-5184)aGc>aTc	p.S1728I		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1728					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GTCATGGATGCTGTGCCTGTC	0.567000													22	110					6.21321e-17	7.17689e-17	1	1	0
TPO	7173	broad.mit.edu	37	2	1507769	1507769	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:1507769G>A	ENST00000345913.4	+	14	2527	c.2436G>A	c.(2434-2436)gcG>gcA	p.A812A	TPO_ENST00000382198.1_Silent_p.A639A|TPO_ENST00000382201.3_Silent_p.A755A|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000346956.3_Intron|TPO_ENST00000337415.3_Silent_p.A812A|TPO_ENST00000329066.4_Silent_p.A812A|TPO_ENST00000349624.3_Silent_p.A639A	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	812	EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACGCCTCTGCGAGGTGCAGAA	0.622000													7	63					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108324266	108324266	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:108324266C>G	ENST00000361582.3	+	2	243	c.13C>G	c.(13-15)Cca>Gca	p.P5A	DZIP3_ENST00000463306.1_Missense_Mutation_p.P5A	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	5					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						GGATTCTCTACCAGATGAATT	0.423000													11	65					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89261450	89261450	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr16:89261450G>A	ENST00000289746.2	+	14	2397	c.2332G>A	c.(2332-2334)Gac>Aac	p.D778N		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	778					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCGGCTGGCAGACATGTATGG	0.667000													7	36					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639514	7639514	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:7639514C>T	ENST00000359156.4	-	9	2321	c.2119G>A	c.(2119-2121)Gaa>Aaa	p.E707K	CD163_ENST00000541972.1_Missense_Mutation_p.E695K|CD163_ENST00000396620.3_Missense_Mutation_p.E740K|CD163_ENST00000432237.2_Missense_Mutation_p.E707K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	707					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GCACTTTCTTCTGGAATGGTA	0.408000													24	98					0	0	1	0	0
IFRD1	3475	broad.mit.edu	37	7	112099011	112099011	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:112099011C>G	ENST00000403825.3	+	5	766	c.505C>G	c.(505-507)Ctt>Gtt	p.L169V	IFRD1_ENST00000486688.1_3'UTR|IFRD1_ENST00000535603.1_Missense_Mutation_p.L119V|IFRD1_ENST00000005558.4_Missense_Mutation_p.L169V	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	169					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						TTTGAAAACTCTTGGACCAAT	0.388000													8	209					0	0	1	0	0
IFFO1	25900	broad.mit.edu	37	12	6659915	6659915	+	Silent	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:6659915C>T	ENST00000336604.4	-	3	917	c.876G>A	c.(874-876)ctG>ctA	p.L292L	IFFO1_ENST00000436152.2_5'UTR|IFFO1_ENST00000356896.4_Silent_p.L292L|IFFO1_ENST00000465801.1_5'UTR|IFFO1_ENST00000396840.2_Silent_p.L292L	NM_080730.4	NP_542768.2	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan 1	292						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						GTTCCACCTTCAGTGCCAGCT	0.582000													9	40					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103354814	103354814	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:103354814C>G	ENST00000520539.1	-	9	1591	c.985G>C	c.(985-987)Gat>Cat	p.D329H	UBR5_ENST00000220959.4_Missense_Mutation_p.D329H|UBR5_ENST00000521922.1_Missense_Mutation_p.D323H	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	329					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTTCATTATCAAATGAGGCT	0.448000													11	157					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79782574	79782574	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:79782574C>T	ENST00000335016.5	+	9	1185	c.1019C>T	c.(1018-1020)cCg>cTg	p.P340L	BMP2K_ENST00000502871.1_Missense_Mutation_p.P340L	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	340						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						CTTCCTGAACCGATGACTGCT	0.333000													6	56					0	0	1	0	0
EIF5A	1984	broad.mit.edu	37	17	7214792	7214792	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:7214792G>C	ENST00000336458.8	+	4	795	c.394G>C	c.(394-396)Gag>Cag	p.E132Q	EIF5A_ENST00000336452.7_Missense_Mutation_p.E162Q|GPS2_ENST00000391950.3_3'UTR|EIF5A_ENST00000576930.1_Missense_Mutation_p.E132Q|EIF5A_ENST00000419711.2_Missense_Mutation_p.E132Q|EIF5A_ENST00000572815.1_Missense_Mutation_p.E132Q|EIF5A_ENST00000573542.1_Missense_Mutation_p.E132Q|EIF5A_ENST00000571955.1_Missense_Mutation_p.E132Q|EIF5A_ENST00000416016.2_Missense_Mutation_p.E132Q	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	132					induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						CTGTGGAGAAGAGATCCTGGT	0.542000													4	105					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7828326	7828326	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:7828326C>T	ENST00000327325.5	+	2	212	c.94C>T	c.(94-96)Caa>Taa	p.Q32*	CLEC4M_ENST00000248228.4_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000359059.5_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000334806.5_Intron|CLEC4M_ENST00000357361.2_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000597522.1_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000394122.2_Nonsense_Mutation_p.Q24*|CLEC4M_ENST00000595496.1_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000596707.1_Nonsense_Mutation_p.Q32*|CLEC4M_ENST00000596363.1_Intron	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	32					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						AAGAGACTTTCAATTCCAGCA	0.522000													6	76					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226273608	226273608	+	Silent	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:226273608C>G	ENST00000272907.6	+	2	425	c.12C>G	c.(10-12)tcC>tcG	p.S4S	NYAP2_ENST00000409269.2_Silent_p.S4S	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	4																	TGATATCCTCCAAGATGATGA	0.428000													9	74					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7786082	7786082	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr10:7786082G>A	ENST00000358415.4	+	18	2413	c.2247G>A	c.(2245-2247)aaG>aaA	p.K749K	ITIH2_ENST00000379587.4_Silent_p.K738K	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	749					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GTGCCAAGAAGCCCAACAATG	0.383000													19	70					0	0	1	0	0
BNIP1	662	broad.mit.edu	37	5	172586982	172586982	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr5:172586982G>T	ENST00000231668.9	+	6	651	c.547G>T	c.(547-549)Gag>Tag	p.E183*	BNIP1_ENST00000393770.4_Nonsense_Mutation_p.E106*|BNIP1_ENST00000351486.5_Nonsense_Mutation_p.E140*|BNIP1_ENST00000352523.6_Nonsense_Mutation_p.E149*	NM_013979.2	NP_053582.2	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 1	140					anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	11	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TACCATCACTGAGAGCCTCAT	0.542000													5	193					0.014758	0.0150777	1	1	0
TUBA3C	7278	broad.mit.edu	37	13	19753597	19753597	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr13:19753597G>A	ENST00000400113.3	-	2	214	c.110C>T	c.(109-111)cCa>cTa	p.P37L		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	37					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TTTATCACTTGGCATCTGACC	0.547000													16	130					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993826	45993826	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr21:45993826C>T	ENST00000400374.3	+	1	221	c.191C>T	c.(190-192)tCc>tTc	p.S64F	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	64	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						AGCCGTGTGTCCAGCCCCTGC	0.716000													13	43					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166297	206166297	+	Silent	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:206166297C>G	ENST00000406610.2	+	18	2709	c.2502C>G	c.(2500-2502)gtC>gtG	p.V834V	PARD3B_ENST00000349953.3_Silent_p.V834V|PARD3B_ENST00000462231.1_Silent_p.V834V|PARD3B_ENST00000358768.2_Silent_p.V772V|PARD3B_ENST00000351153.1_Silent_p.V765V	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	834	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCAGGAAAGTCAAAAAAACga	0.428000													12	48					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38162107	38162107	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr8:38162107C>G	ENST00000317025.8	-	14	3126	c.2609G>C	c.(2608-2610)aGa>aCa	p.R870T	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.R870T|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.R870T	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	870					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			ACACTCACCTCTGGCACAAAC	0.393000			T	NUP98	AML								18	294					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99767356	99767356	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:99767356G>C	ENST00000370185.3	+	6	1366	c.869G>C	c.(868-870)gGa>gCa	p.G290A	LPPR4_ENST00000370184.1_Missense_Mutation_p.G132A|LPPR4_ENST00000457765.1_Intron	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		290							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ATCATCTGTGGAATAATCTGC	0.388000													16	120					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4558249	4558249	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr3:4558249G>A	ENST00000302640.8	+	3	424	c.74G>A	c.(73-75)gGa>gAa	p.G25E	ITPR1_ENST00000456211.2_Missense_Mutation_p.G25E|ITPR1_ENST00000354582.6_Missense_Mutation_p.G25E|ITPR1_ENST00000423119.2_Missense_Mutation_p.G25E|ITPR1_ENST00000443694.2_Missense_Mutation_p.G25E|ITPR1_ENST00000357086.4_Missense_Mutation_p.G25E|ITPR1_ENST00000544951.1_Missense_Mutation_p.G25E	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	25					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCGACAAATGGATTTATTAGC	0.378000													10	123					0	0	1	0	0
ZNF467	168544	broad.mit.edu	37	7	149461881	149461881	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:149461881G>C	ENST00000302017.3	-	5	2123	c.1710C>G	c.(1708-1710)caC>caG	p.H570Q	ZNF467_ENST00000484747.1_Intron	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGGGGCCGCGTGGGCGGCTT	0.711000													11	25					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49190661	49190661	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:49190661G>A	ENST00000406846.2	-	10	1418	c.1299C>T	c.(1297-1299)gcC>gcT	p.A433A	FSHR_ENST00000304421.4_Silent_p.A407A|FSHR_ENST00000541117.1_Silent_p.A169A|FSHR_ENST00000346173.3_Silent_p.A371A	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	433					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GCCAGTCAATGGCATAGTTGT	0.473000									Gonadal Dysgenesis, 46 XX				18	79					0	0	1	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70819809	70819809	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:70819809G>C	ENST00000370944.4	-	1	596	c.283C>G	c.(283-285)Ctg>Gtg	p.L95V	ANKRD13C_ENST00000262346.6_Missense_Mutation_p.L95V	NM_030816.4	NP_110443.3	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	95					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	19						GTGCCGGCCAGAAGGGCCGGG	0.672000													9	64					0	0	1	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41753234	41753234	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:41753234C>T	ENST00000359201.5	+	5	1127	c.538C>T	c.(538-540)Cat>Tat	p.H180Y	PRICKLE4_ENST00000458694.1_Missense_Mutation_p.H180Y|PRICKLE4_ENST00000394259.1_Missense_Mutation_p.H140Y|PRICKLE4_ENST00000394260.1_Missense_Mutation_p.H140Y|PRICKLE4_ENST00000394263.1_Missense_Mutation_p.H180Y			Q2TBC4	PRIC4_HUMAN	prickle homolog 4 (Drosophila)	140	LIM zinc-binding 2.					nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	13	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGCGGCCGTCATCATGCAGA	0.617000													8	57					0	0	1	0	0
IGLV10-54	28772	broad.mit.edu	37	22	22569391	22569391	+	RNA	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr22:22569391C>G	ENST00000390287.2	+	0	96																											CAGCCACCCTCGGTGTCCAAG	0.592000													4	18					0	0	1	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75763946	75763946	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:75763946G>C	ENST00000312442.2	+	5	738	c.692G>C	c.(691-693)aGa>aCa	p.R231T	CAPS2_ENST00000442339.2_Intron|GLIPR1L1_ENST00000378695.4_Missense_Mutation_p.R240T|GLIPR1L1_ENST00000548623.1_3'UTR	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	240						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						CTTCTTCTGAGAATCTTTTAA	0.313000													7	55					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69433570	69433570	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:69433570C>G	ENST00000317746.2	-	1	675	c.633G>C	c.(631-633)agG>agC	p.R211S		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	211					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TATTTTTTATCCTCTCCATGA	0.353000													18	276					0	0	1	0	0
RHOH	399	broad.mit.edu	37	4	40245496	40245496	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr4:40245496G>C	ENST00000381799.4	+	3	1214	c.490G>C	c.(490-492)Gag>Cag	p.E164Q	RHOH_ENST00000505618.1_Missense_Mutation_p.E164Q	NM_001278363.1|NM_001278365.1|NM_004310.3	NP_001265292.1|NP_001265294.1|NP_004301.1	Q15669	RHOH_HUMAN	ras homolog family member H	164					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			kidney(1)|large_intestine(3)|lung(7)|ovary(1)	12						GCAGGTGTTTGAGTGCGCCGT	0.547000													11	47					0	0	1	0	0
NDUFV1	4723	broad.mit.edu	37	11	67376948	67376948	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:67376948G>C	ENST00000322776.6	+	4	505	c.352G>C	c.(352-354)Gac>Cac	p.D118H	NDUFV1_ENST00000415352.2_Missense_Mutation_p.D111H|NDUFV1_ENST00000532303.1_Missense_Mutation_p.D17H|NDUFV1_ENST00000526169.1_3'UTR|NDUFV1_ENST00000529927.1_Missense_Mutation_p.D109H	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	118					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	GGTGAACGCAGACGAGGGGGA	0.652000													23	100					0	0	1	0	0
CCDC28B	79140	broad.mit.edu	37	1	32670262	32670262	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:32670262G>C	ENST00000421922.2	+	5	689	c.589G>C	c.(589-591)Gag>Cag	p.E197Q	CCDC28B_ENST00000373602.5_Intron|CCDC28B_ENST00000483009.1_Intron			Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	0										large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GTGTGTTCCTGAGAGGTCAGT	0.493000													15	174					0	0	1	0	0
RFPL3	10738	broad.mit.edu	37	22	32754310	32754310	+	Silent	SNP	C	C	G			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr22:32754310C>G	ENST00000249007.4	+	1	457	c.252C>G	c.(250-252)gtC>gtG	p.V84V	RFPL3_ENST00000397468.1_Silent_p.V55V|RFPL3_ENST00000382088.3_Silent_p.V55V	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	84							zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						GTTCCATGGTCTCTCAGAGGA	0.532000													12	100					0	0	1	0	0
TFEB	7942	broad.mit.edu	37	6	41658473	41658473	+	Silent	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr6:41658473G>C	ENST00000394283.1	-	3	1622	c.396C>G	c.(394-396)tcC>tcG	p.S132S	TFEB_ENST00000373033.1_Silent_p.S132S|TFEB_ENST00000358871.2_Silent_p.S146S|TFEB_ENST00000403298.4_Silent_p.S132S|TFEB_ENST00000420312.1_Intron|TFEB_ENST00000230323.4_Silent_p.S132S			P19484	TFEB_HUMAN	transcription factor EB	132				GSPKPPPAASPGVRAGHVLSSSAGNSAPN -> ALRNPHQP PPQGCELDTCCPPPLATVLPI (in Ref. 1; AAA36730).	embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			CAGCGGAGGAGGACAGCACGT	0.642000			T	ALPHA	renal (childhood epithelioid)								8	27					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55860975	55860975	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:55860975C>A	ENST00000302124.2	+	1	223	c.192C>A	c.(190-192)agC>agA	p.S64R	OR8I2_ENST00000560768.1_Missense_Mutation_p.S64R			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TTTTCCTGAGCAATTTAGCAT	0.393000													17	209					4.7546e-09	5.38221e-09	1	1	0
LRP2	4036	broad.mit.edu	37	2	170113747	170113747	+	Silent	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:170113747G>A	ENST00000263816.3	-	18	2811	c.2526C>T	c.(2524-2526)ttC>ttT	p.F842F	LRP2_ENST00000443831.1_Silent_p.F705F	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	842					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCAATCAGTGAAGAATAGAT	0.418000													4	56					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000657	56000657	+	Missense_Mutation	SNP	G	G	C	rs113109292	by1000genomes	TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr11:56000657G>C	ENST00000313264.4	-	1	80	c.5C>G	c.(4-6)tCg>tGg	p.S2W		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TATACTGTACGACATATATTC	0.378000													5	123					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114454526	114454526	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr9:114454526G>A	ENST00000394779.3	-	23	3666	c.3422C>T	c.(3421-3423)cCa>cTa	p.P1141L	C9orf84_ENST00000318737.4_Missense_Mutation_p.P1180L|C9orf84_ENST00000394777.4_Missense_Mutation_p.P1106L|C9orf84_ENST00000374287.3_Missense_Mutation_p.P1180L	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	1180										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AGTCACAGGTGGTAAAAAACT	0.363000													12	85					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47287910	47287910	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:47287910G>A	ENST00000319190.5	+	19	2523	c.2155G>A	c.(2155-2157)Gag>Aag	p.E719K	TTC7A_ENST00000394850.2_Missense_Mutation_p.E743K|TTC7A_ENST00000263737.6_Missense_Mutation_p.E365K|TTC7A_ENST00000409245.1_Missense_Mutation_p.E685K	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	719							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTTTGCAGCTGAGCTGTTCAT	0.587000													6	89					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52703972	52703972	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:52703972G>T	ENST00000287727.3	+	4	1055	c.883G>T	c.(883-885)Ggc>Tgc	p.G295C	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.G295C|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.G295C|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.G295C	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	295					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GGACCTCACTGGCAAAATCAG	0.443000													17	118					9.16793e-09	1.03367e-08	1	1	0
CNNM3	26505	broad.mit.edu	37	2	97490833	97490833	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:97490833G>A	ENST00000305510.3	+	2	1292	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	ANKRD23_ENST00000476975.1_Intron|CNNM3_ENST00000377060.3_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	422	CBS 2.				ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						GGTGAACAACGAGGGTGAAGG	0.602000													3	32					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578500	7578500	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr17:7578500G>A	ENST00000420246.2	-	5	562	c.430C>T	c.(430-432)Cag>Tag	p.Q144*	TP53_ENST00000445888.2_Nonsense_Mutation_p.Q144*|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q144*|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q144*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q144*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q144*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	144	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).|Q -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(36)|p.0?(8)|p.Q144fs*25(3)|p.Q144K(2)|p.Q12*(2)|p.Q144fs*26(2)|p.Q51*(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q51fs*25(1)|p.Q144del(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.P142_Q144delPVQ(1)|p.Q144fs*4(1)|p.Q12fs*25(1)|p.V143_S149del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCCACAGCTGCACAGGGCAG	0.597000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	47					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137391	32137391	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:32137391G>C	ENST00000312561.4	+	4	3916	c.3502G>C	c.(3502-3504)Gat>Cat	p.D1168H	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CTCTGAGAAAGATGATATCCA	0.483000													9	101					0	0	1	0	0
CYBB	1536	broad.mit.edu	37	X	37660572	37660572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chrX:37660572C>T	ENST00000378588.4	+	8	935	c.868C>T	c.(868-870)Cga>Tga	p.R290*	CYBB_ENST00000536160.1_Nonsense_Mutation_p.R23*|CYBB_ENST00000492288.1_3'UTR|TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000545017.1_Nonsense_Mutation_p.R258*	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	290	FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						GCGGTTTTGGCGATCTCAACA	0.413000													6	259					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66603261	66603261	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr12:66603261G>C	ENST00000261233.4	+	3	763	c.342G>C	c.(340-342)aaG>aaC	p.K114N	IRAK3_ENST00000457197.2_Missense_Mutation_p.K53N	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	114					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		CTTCAGAGAAGAGTTATCAGG	0.348000													5	89					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109312	145109313	+	RNA	INS	-	-	A	rs148903206		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr1:145109312_145109313insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										aaaccaaaaacaaaAAAAAAAG	0.416													2	4	---	---	---	---					
KLF11	8462	broad.mit.edu	37	2	10188608	10188609	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:10188608_10188609delTG	ENST00000535335.1	+	3	1309_1310	c.1093_1094delTG	c.(1093-1095)tfs	p.C365fs	KLF11_ENST00000540845.1_Frame_Shift_Del_p.C365fs|KLF11_ENST00000305883.1_Frame_Shift_Del_p.C382fs	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	382					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		TAGCCAAAACTGTGTCCCTCAG	0.550											OREG0014425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	118	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89102192	89102194	+	RNA	DEL	AAG	AAG	-			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr2:89102192_89102194delAAG	ENST00000393525.3	+	0	2666_2668																											GTTTAATAATAAGGTGATTTGTA	0.330													3	6	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149526674	149526675	+	RNA	DEL	CT	CT	-			TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr7:149526674_149526675delCT	ENST00000378016.2	+	0	15142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ccacagtcccctcagtcccctc	0.653													5	3	---	---	---	---					
CEACAM5	1048	broad.mit.edu	37	19	42221545	42221560	+	Frame_Shift_Del	DEL	CCCTCACTCTACTCAG	CCCTCACTCTACTCAG	-	rs145041033		TCGA-QK-A6VC-01A-23D-A34J-08	TCGA-QK-A6VC-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	01413c18-357f-4712-8f1a-27703425b1c9	a98f75ad-eb15-4f88-b3e3-e7427c58bec3	g.chr19:42221545_42221560delCCCTCACTCTACTCAG	ENST00000221992.6	+	5	1244_1259	c.1130_1145delCCCTCACTCTACTCAG	c.(1129-1146)atfs	p.TLTLLS377fs	CEACAM5_ENST00000398599.4_Frame_Shift_Del_p.TLTLLS376fs|CEACAM5_ENST00000405816.1_Frame_Shift_Del_p.TLTLLS377fs|CEA_ENST00000598976.1_Intron	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	377	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GACAACAGGACCCTCACTCTACTCAGTGTCACAAGG	0.491													9	265	---	---	---	---					
