Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL14A1	7373	broad.mit.edu	37	8	121290456	121290456	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr8:121290456G>A	ENST00000297848.3	+	27	3590	c.3320G>A	c.(3319-3321)gGa>gAa	p.G1107E	COL14A1_ENST00000309791.4_Missense_Mutation_p.G1107E|COL14A1_ENST00000247781.3_Missense_Mutation_p.G1012E	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1107	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCATACAAAGGAGGAAATACA	0.333000													24	45					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25971150	25971150	+	Silent	SNP	G	G	A	rs141485196		TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:25971150G>A	ENST00000356865.6	-	5	1038	c.927C>T	c.(925-927)gaC>gaT	p.D309D		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	309					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACCAGAGCACGTCGCAGTTCA	0.562000													26	95					0	0	1	0	0
CAPN12	147968	broad.mit.edu	37	19	39234622	39234622	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:39234622G>A	ENST00000328867.4	-	1	492	c.184C>T	c.(184-186)Cag>Tag	p.Q62*	CAPN12_ENST00000601953.1_Intron	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	62	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GGCCCCAGCTGGTCATAGCCA	0.632000													5	75					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62376848	62376848	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:62376848C>A	ENST00000394773.2	-	6	1043	c.736G>T	c.(736-738)Gag>Tag	p.E246*	EML3_ENST00000494176.2_Nonsense_Mutation_p.E218*|EML3_ENST00000278845.4_Nonsense_Mutation_p.E247*|EML3_ENST00000531557.1_Nonsense_Mutation_p.E29*|EML3_ENST00000529309.1_Nonsense_Mutation_p.E246*	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	246						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTGAGGGTCTCTGGCGGTGGG	0.582000													73	44					9.98788e-38	1.25443e-37	1	1	0
AFF3	3899	broad.mit.edu	37	2	100210742	100210742	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:100210742C>T	ENST00000317233.4	-	14	1616	c.1381G>A	c.(1381-1383)Gca>Aca	p.A461T	AFF3_ENST00000356421.2_Missense_Mutation_p.A486T|AFF3_ENST00000409236.1_Missense_Mutation_p.A461T|AFF3_ENST00000409579.1_Missense_Mutation_p.A486T	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	461					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.A486T(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TTAGAGGATGCCGGTTCAGCC	0.443000													6	383					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102290593	102290593	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:102290593A>C	ENST00000370103.4	-	4	794	c.581T>G	c.(580-582)aTg>aGg	p.M194R	OLFM3_ENST00000536598.1_Missense_Mutation_p.M119R|OLFM3_ENST00000338858.5_Missense_Mutation_p.M214R|OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000359814.3_Missense_Mutation_p.M214R	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	214						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TAGCTTTTTCATGCAGTCACG	0.363000													38	50					0	0	1	0	0
SLC2A6	11182	broad.mit.edu	37	9	136340583	136340583	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:136340583C>T	ENST00000371899.4	-	5	790	c.713G>A	c.(712-714)cGt>cAt	p.R238H	SLC2A6_ENST00000485978.1_5'UTR|SLC2A6_ENST00000371897.4_Missense_Mutation_p.R238H	NM_017585.3	NP_060055.2	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 6	238						integral to membrane|plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GTCCGTCCCACGCAGCCAGGC	0.667000													22	39					0	0	1	0	0
RXFP3	51289	broad.mit.edu	37	5	33937022	33937022	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:33937022C>T	ENST00000330120.3	+	1	532	c.177C>T	c.(175-177)ggC>ggT	p.G59G		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	59						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						TGCCGGACGGCGCGCCGCCAG	0.697000													11	104					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528044	125528044	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:125528044C>T	ENST00000241305.3	-	9	1451	c.1297G>A	c.(1297-1299)Ggg>Agg	p.G433R	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	433					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GCCATTACCCCTTCGTAGGCC	0.612000													23	41					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40317350	40317350	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:40317350C>T	ENST00000593685.1	-	9	1841	c.1373G>A	c.(1372-1374)tGc>tAc	p.C458Y	DYRK1B_ENST00000323039.5_Missense_Mutation_p.C458Y|DYRK1B_ENST00000430012.2_Missense_Mutation_p.C418Y|DYRK1B_ENST00000597639.1_Missense_Mutation_p.C430Y|DYRK1B_ENST00000348817.3_Missense_Mutation_p.C430Y			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	458					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GGAAGAGGGGCAGGTGTCGAG	0.697000													3	10					0	0	1	0	0
AGPS	8540	broad.mit.edu	37	2	178301583	178301583	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:178301583A>C	ENST00000264167.4	+	4	679	c.533A>C	c.(532-534)gAg>gCg	p.E178A	AGPS_ENST00000409888.1_Intron	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase	178					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TATTCACAAGAGGCAGATGAT	0.289000													8	101					0	0	1	0	0
RNF130	55819	broad.mit.edu	37	5	179440198	179440198	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:179440198G>A	ENST00000522208.2	-	3	574	c.556C>T	c.(556-558)Cca>Tca	p.P186S	RNF130_ENST00000261947.4_Missense_Mutation_p.P186S|RNF130_ENST00000521389.1_Missense_Mutation_p.P186S			Q86XS8	GOLI_HUMAN	ring finger protein 130	186					apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	17	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTTCGGTGGCATTCGAGTT	0.378000													60	24					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9967987	9967987	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:9967987G>A	ENST00000264833.4	-	4	717	c.532C>T	c.(532-534)Cgg>Tgg	p.R178W	OLFM2_ENST00000590841.1_Missense_Mutation_p.R100W	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	178						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						GCCATCACCCGTTGCTGCAGG	0.637000													9	107					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951472	119951472	+	Silent	SNP	A	A	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:119951472A>T	ENST00000307142.4	+	4	1738	c.1542A>T	c.(1540-1542)gtA>gtT	p.V514V	SYNPO2_ENST00000429713.2_Silent_p.V514V|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Silent_p.V514V	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	514						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AGGACAAGGTAGGTGGAACGC	0.517000													12	29					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74068434	74068434	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:74068434C>T	ENST00000307877.2	-	1	300	c.139G>A	c.(139-141)Gga>Aga	p.G47R	SRP68_ENST00000539137.1_Missense_Mutation_p.G47R|SRP68_ENST00000355113.5_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	47					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						GCCTTCGATCCGGCCGAAGGG	0.592000													187	496					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121748015	121748015	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:121748015C>A	ENST00000452319.1	+	14	4585	c.4525C>A	c.(4525-4527)Cag>Aag	p.Q1509K	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Missense_Mutation_p.Q1509K			P10070	GLI2_HUMAN	GLI family zinc finger 2	1509					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGAGGCCCCCCAGATTGACTT	0.622000													10	374					1.58986e-06	1.72918e-06	1	1	0
HDAC4	9759	broad.mit.edu	37	2	239975193	239975193	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:239975193C>A	ENST00000345617.3	-	26	3969	c.3178G>T	c.(3178-3180)Gcc>Tcc	p.A1060S	HDAC4_ENST00000543185.1_Missense_Mutation_p.A644S	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	1060	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GACAGCGAGGCCATGGCGGTG	0.667000													57	17					2.12129e-23	2.58723e-23	1	1	0
SDHAP1	255812	broad.mit.edu	37	3	195698264	195698264	+	RNA	SNP	T	T	C	rs12485654	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:195698264T>C	ENST00000427841.1	-	0	1608					NR_003264.2																						TTTGTCAACATTCGTGACAGA	0.413000													11	174					0	0	1	0	0
PSMD13	5719	broad.mit.edu	37	11	251889	251889	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:251889C>T	ENST00000532097.1	+	12	1492	c.988C>T	c.(988-990)Cga>Tga	p.R330*	PSMD13_ENST00000532025.1_3'UTR|PSMD13_ENST00000431206.2_Nonsense_Mutation_p.R332*|PSMD13_ENST00000352303.5_Nonsense_Mutation_p.R303*	NM_002817.3	NP_002808.3	Q9UNM6	PSD13_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	330	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	10		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.79e-27)|Epithelial(43;4e-26)|OV - Ovarian serous cystadenocarcinoma(40;6.02e-21)|BRCA - Breast invasive adenocarcinoma(625;3.93e-05)|Lung(200;0.112)|LUSC - Lung squamous cell carcinoma(625;0.129)		GGTGGACAAACGAGTCCACAT	0.527000													51	198					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183195922	183195922	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:183195922G>C	ENST00000264144.4	+	9	1221	c.1156G>C	c.(1156-1158)Gtt>Ctt	p.V386L	LAMC2_ENST00000493293.1_Missense_Mutation_p.V386L	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	386	Laminin EGF-like 4; second part.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TATATGTCCTGTTGGGTACAA	0.522000													22	245					0	0	1	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652235	45652235	+	RNA	SNP	C	C	G	rs149362183		TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:45652235C>G	ENST00000427229.2	+	0	1749																											GAAGGAACATCTGAAGGAACA	0.478000													5	18					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141739846	141739846	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:141739846C>A	ENST00000389484.3	-	18	3742		c.e18-1			NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATGTTCTGGCTATGATGATC	0.393000										TSP Lung(27;0.18)			22	9					2.70639e-06	2.89873e-06	1	1	0
NLRP2	55655	broad.mit.edu	37	19	55494318	55494318	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:55494318C>A	ENST00000543010.1	+	6	1395	c.1252C>A	c.(1252-1254)Ccg>Acg	p.P418T	NLRP2_ENST00000427260.2_Missense_Mutation_p.P395T|NLRP2_ENST00000538819.1_Missense_Mutation_p.P394T|NLRP2_ENST00000448584.2_Missense_Mutation_p.P418T|NLRP2_ENST00000537859.1_Missense_Mutation_p.P396T|NLRP2_ENST00000339757.7_Missense_Mutation_p.P396T|NLRP2_ENST00000391721.4_Missense_Mutation_p.P394T|NLRP2_ENST00000263437.6_Missense_Mutation_p.P415T	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	418	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGGGAGGACCCGGTCCCCAC	0.697000													8	22					7.48243e-07	8.18027e-07	1	1	0
CROT	54677	broad.mit.edu	37	7	86998740	86998740	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:86998740G>A	ENST00000331536.3	+	7	781	c.596G>A	c.(595-597)cGa>cAa	p.R199Q	CROT_ENST00000442291.1_Missense_Mutation_p.R199Q|CROT_ENST00000419147.2_Missense_Mutation_p.R227Q	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	199					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGTCGAGGCCGAGCTTTTGTC	0.438000													72	91					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121416012	121416012	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:121416012T>C	ENST00000393667.3	-	13	3468	c.3358A>G	c.(3358-3360)Atc>Gtc	p.I1120V	GOLGB1_ENST00000340645.5_Missense_Mutation_p.I1115V	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1115					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTTTCACTGATTTCTGCTTGG	0.418000													112	118					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126081423	126081423	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:126081423G>A	ENST00000298317.4	-	1	164	c.111C>T	c.(109-111)gcC>gcT	p.A37A	RPUSD4_ENST00000533628.1_Silent_p.A37A|FAM118B_ENST00000533050.1_5'UTR	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	37	Poly-Ala.				pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		TGGCCGTAGAGGCAGCGGCAG	0.597000													136	146					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23299924	23299924	+	RNA	SNP	C	C	T	rs148090660	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:23299924C>T	ENST00000560464.1	-	0	4363																											CCAGGCAAGCCGGACGCATTC	0.577000													3	29					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195698262	195698262	+	RNA	SNP	C	C	G	rs28503679	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:195698262C>G	ENST00000427841.1	-	0	1610					NR_003264.2																						AATTTGTCAACATTCGTGACA	0.418000													11	177					0	0	1	0	0
ADORA2A	135	broad.mit.edu	37	22	24837117	24837117	+	Missense_Mutation	SNP	G	G	A	rs4990	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:24837117G>A	ENST00000337539.7	+	3	1358	c.899G>A	c.(898-900)cGc>cAc	p.R300H	ADORA2A_ENST00000496497.1_3'UTR|KB-1896H10.1_ENST00000358654.2_3'UTR|ADORA2A-AS1_ENST00000543438.1_RNA|ADORA2A-AS1_ENST00000326341.4_RNA|ADORA2A-AS1_ENST00000427813.2_RNA	NM_000675.4|NM_001278497.1|NM_001278498.1|NM_001278499.1|NM_001278500.1	NP_000666.2|NP_001265426.1|NP_001265427.1|NP_001265428.1|NP_001265429.1	P29274	AA2AR_HUMAN	adenosine A2a receptor	300			R -> H (in dbSNP:rs4990).		apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|skin(1)	21	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CAGACCTTCCGCAAGATCATT	0.587000													9	49					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139405702	139405702	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:139405702A>T	ENST00000277541.6	-	16	2564	c.2489T>A	c.(2488-2490)cTg>cAg	p.L830Q		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	830	EGF-like 22.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACACGGGGCCAGCACCACCTC	0.657000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			21	25					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789962	133789962	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:133789962C>T	ENST00000321016.8	-	18	3888	c.3658G>A	c.(3658-3660)Gcc>Acc	p.A1220T	IGSF9B_ENST00000533871.2_Missense_Mutation_p.A1220T			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1220	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CGGGCACGGGCGGCGAGCTCA	0.672000													33	33					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17578709	17578709	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:17578709G>T	ENST00000319363.6	+	3	319	c.186G>T	c.(184-186)tgG>tgT	p.W62C	IL17RA_ENST00000477874.1_3'UTR	NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	62					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		ATGACAGCTGGATTCACCCTC	0.577000													12	65					0.0931896	0.0936333	1	1	0
MUC17	140453	broad.mit.edu	37	7	100683582	100683582	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:100683582C>A	ENST00000306151.4	+	3	8949	c.8885C>A	c.(8884-8886)tCt>tAt	p.S2962Y		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2962	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCACCACTTCTGCTGAAGCT	0.493000													144	268					3.69866e-55	4.72981e-55	1	1	0
NLRP10	338322	broad.mit.edu	37	11	7981913	7981913	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:7981913G>T	ENST00000328600.2	-	2	1407	c.1246C>A	c.(1246-1248)Cta>Ata	p.L416I		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	416	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCAGCTGCTAGGGAGCACAGA	0.547000													13	70					0.0931896	0.0936333	1	1	0
LRRN3	54674	broad.mit.edu	37	7	110763329	110763329	+	Silent	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:110763329T>A	ENST00000451085.1	+	4	1547	c.501T>A	c.(499-501)ctT>ctA	p.L167L	IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000415362.1_Intron|LRRN3_ENST00000308478.5_Silent_p.L167L|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000422987.3_Silent_p.L167L|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000452895.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	167						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATAATCTTCTTCGACTTCATC	0.363000													66	60					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197316469	197316469	+	Splice_Site	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:197316469G>A	ENST00000367400.3	+	4	983		c.e4-1		CRB1_ENST00000538660.1_Splice_Site|CRB1_ENST00000535699.1_Splice_Site|CRB1_ENST00000543483.1_Splice_Site|CRB1_ENST00000367399.2_Intron	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)						cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTACTTTCCAGATATAGCTGT	0.393000													7	115					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57752328	57752328	+	Silent	SNP	C	C	T	rs141029220	byFrequency	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:57752328C>T	ENST00000274289.3	-	9	1545	c.1245G>A	c.(1243-1245)agG>agA	p.R415R	PLK2_ENST00000502671.1_5'UTR	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	415					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		CCTCATCTGTCCTGTGTTTGC	0.368000													6	171					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118529659	118529659	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:118529659C>A	ENST00000311085.8	+	30	7531	c.7451C>A	c.(7450-7452)tCa>tAa	p.S2484*	DMXL1_ENST00000539542.1_Nonsense_Mutation_p.S2484*	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2484										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AATTCAAATTCATATAGGTAT	0.264000													9	5					0.307466	0.307466	1	1	0
CHERP	10523	broad.mit.edu	37	19	16638968	16638968	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:16638968G>T	ENST00000546361.2	-	9	1379	c.1228C>A	c.(1228-1230)Cca>Aca	p.P410T	CHERP_ENST00000198939.6_Missense_Mutation_p.P421T|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	410	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						TGGTCGTGTggcccggggccc	0.642000													49	118					3.76525e-18	4.53981e-18	1	1	0
PCDH8	5100	broad.mit.edu	37	13	53420293	53420293	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:53420293C>A	ENST00000377942.3	-	1	2482	c.2279G>T	c.(2278-2280)tGc>tTc	p.C760F	PCDH8_ENST00000338862.4_Missense_Mutation_p.C760F	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	760					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGCAGCGTGCAGCTCCCGGC	0.716000													4	74					0.014758	0.0151162	1	1	0
TRIM42	287015	broad.mit.edu	37	3	140407285	140407285	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:140407285C>T	ENST00000286349.3	+	3	1952	c.1761C>T	c.(1759-1761)agC>agT	p.S587S		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	587						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TACAGAACAGCAGCAGCTTCC	0.572000													56	155					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79268721	79268721	+	Translation_Start_Site	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:79268721T>C	ENST00000374759.3	-	1	384	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	SLC38A10_ENST00000288439.5_Start_Codon_SNP_p.M1V	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	1					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCCGCGGTCATAGTGAGAGGT	0.667000													54	32					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538603	4538603	+	Silent	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:4538603C>A	ENST00000306390.6	-	2	853	c.393G>T	c.(391-393)ctG>ctT	p.L131L	LRG1_ENST00000586883.1_5'UTR|CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	131						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCGGGGGCAGCCCGGTCA	0.632000													42	100					5.04308e-16	5.97803e-16	1	1	0
ATXN1	6310	broad.mit.edu	37	6	16327921	16327921	+	Missense_Mutation	SNP	C	C	A	rs142039862	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:16327921C>A	ENST00000244769.4	-	8	1557	c.621G>T	c.(619-621)caG>caT	p.Q207H	ATXN1_ENST00000436367.1_Missense_Mutation_p.Q207H	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	207	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.Q207H(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgatgctgctgctgctgct	0.662000													4	29					0.00909568	0.0093619	1	1	0
TUBA4B	80086	broad.mit.edu	37	2	220136572	220136572	+	RNA	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:220136572A>G	ENST00000490341.1	+	0	1042					NR_003063.1																						TTTAAGGTTGATATCAATCAC	0.537000													32	25					0	0	1	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46058062	46058062	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr21:46058062T>G	ENST00000380095.1	+	1	790	c.728T>G	c.(727-729)cTc>cGc	p.L243R	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	243						keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						TGCTACAGCCTCTGCTCTGGC	0.687000													30	26					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37471214	37471214	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:37471214C>A	ENST00000381792.2	-	11	1443	c.1303G>T	c.(1303-1305)Ggt>Tgt	p.G435C	TMPRSS6_ENST00000406725.1_Missense_Mutation_p.G435C|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.G444C|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.G435C			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	444	CUB 2.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						ACCCGCACACCGGGCCCGGTG	0.657000													38	91					4.16155e-14	4.8513e-14	1	1	0
FAM120A	23196	broad.mit.edu	37	9	96289498	96289498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:96289498C>T	ENST00000277165.6	+	8	1674	c.1480C>T	c.(1480-1482)Cga>Tga	p.R494*	FAM120A_ENST00000375389.3_Nonsense_Mutation_p.R494*|FAM120A_ENST00000333936.5_Nonsense_Mutation_p.R522*|FAM120A_ENST00000340893.4_Nonsense_Mutation_p.R494*	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	494						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GCCTCAGGCACGAGGAGACCC	0.418000													12	45					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358471	72358471	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:72358471G>T	ENST00000441259.1	-	3	1166	c.1006C>A	c.(1006-1008)Cct>Act	p.P336T	PRF1_ENST00000373209.2_Missense_Mutation_p.P336T	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	336	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						ACCAGGCCAGGGCTGCCGGGC	0.662000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				22	31					1.55795e-14	1.83646e-14	1	1	0
ZNF254	9534	broad.mit.edu	37	19	24288784	24288784	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:24288784G>A	ENST00000357002.4	+	2	188	c.73G>A	c.(73-75)Gag>Aag	p.E25K	ZNF254_ENST00000342944.6_Intron|ZNF254_ENST00000339642.6_Missense_Mutation_p.E25K	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	25	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATTCTCTCTGGAGGAGTGGCA	0.413000													87	164					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129874990	129874990	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:129874990C>G	ENST00000254667.3	+	18	2002	c.1723C>G	c.(1723-1725)Cag>Gag	p.Q575E	PTPRE_ENST00000419012.2_Missense_Mutation_p.Q575E|PTPRE_ENST00000306042.5_Missense_Mutation_p.Q517E	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	575	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CACTCTCAATCAGGTATTGTT	0.448000													61	131					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46657616	46657616	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:46657616G>C	ENST00000544460.1	+	1	2005	c.1751G>C	c.(1750-1752)aGg>aCg	p.R584T	TDRD6_ENST00000316081.6_Missense_Mutation_p.R584T	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	584	Tudor 3.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TATGACGTAAGGATGCTGCTT	0.463000													45	110					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774102	140774102	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:140774102C>T	ENST00000398604.2	+	1	1722	c.1722C>T	c.(1720-1722)ggC>ggT	p.G574G	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCCACTGGCGTGGAGCTGG	0.662000													118	59					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279294	36279294	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:36279294C>T	ENST00000007510.4	+	21	3971	c.3827C>T	c.(3826-3828)tCc>tTc	p.S1276F	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.S1112F|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.S1115F			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1276					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CCCAGCTGGTCCCTCCACTCT	0.647000													4	3					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40434017	40434017	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:40434017G>A	ENST00000221347.6	-	2	259	c.252C>T	c.(250-252)ccC>ccT	p.P84P		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	84	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCGACTCCCCGGGCCTCACTG	0.562000													79	94					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58740623	58740623	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:58740623C>T	ENST00000305921.3	+	6	1760	c.1528C>T	c.(1528-1530)Caa>Taa	p.Q510*		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	510					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TGTCATGGACCAAAAAAATTT	0.378000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	42	116					0	0	1	0	0
PSMA4	5685	broad.mit.edu	37	15	78838080	78838080	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:78838080G>T	ENST00000044462.7	+	7	631	c.481G>T	c.(481-483)Gcc>Tcc	p.A161S	PSMA4_ENST00000413382.2_Missense_Mutation_p.A90S|PSMA4_ENST00000557929.1_3'UTR|PSMA4_ENST00000560217.1_Missense_Mutation_p.A130S|PSMA4_ENST00000558341.1_Intron|PSMA4_ENST00000559082.1_Missense_Mutation_p.A161S|PSMA4_ENST00000558281.1_Missense_Mutation_p.A161S|PSMA4_ENST00000558094.1_Missense_Mutation_p.A73S	NM_002789.4	NP_002780.1	P25789	PSA4_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 4	161					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						GGGATGGAAGGCCACATGCAT	0.418000													5	222					0.000602214	0.000629046	1	1	0
POLR2A	5430	broad.mit.edu	37	17	7416817	7416817	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:7416817G>A	ENST00000322644.6	+	29	5633	c.5234G>A	c.(5233-5235)aGc>aAc	p.S1745N		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1745	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				tcacccaccagcccGAACTAT	0.537000													152	63					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20803514	20803514	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:20803514G>T	ENST00000359062.3	+	14	2945	c.2905G>T	c.(2905-2907)Gtc>Ttc	p.V969F	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	969	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGATGGTATTGTCAATGAATT	0.363000													4	65					0.00024832	0.000260674	1	1	0
GDF10	2662	broad.mit.edu	37	10	48429054	48429054	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:48429054C>T	ENST00000224605.2	-	2	1097	c.832G>A	c.(832-834)Gca>Aca	p.A278T		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	278					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TTGGGGGCTGCGCGGGGCTCG	0.701000													6	10					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31418318	31418318	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:31418318G>C	ENST00000373747.3	-	18	2971	c.2872C>G	c.(2872-2874)Cgg>Ggg	p.R958G	PUM1_ENST00000423018.2_Missense_Mutation_p.R813G|PUM1_ENST00000373742.2_Missense_Mutation_p.R896G|PUM1_ENST00000257075.5_Missense_Mutation_p.R955G|PUM1_ENST00000373741.4_Missense_Mutation_p.R993G|PUM1_ENST00000424085.2_Missense_Mutation_p.R713G|PUM1_ENST00000426105.2_Missense_Mutation_p.R957G|PUM1_ENST00000440538.2_Missense_Mutation_p.R931G	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	955	PUM-HD.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TCTAGTTCCCGAACCATCTCA	0.408000													35	15					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78023975	78023975	+	Missense_Mutation	SNP	G	G	A	rs61736668		TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:78023975G>A	ENST00000397545.4	+	7	1079	c.1052G>A	c.(1051-1053)cGc>cAc	p.R351H	CCDC40_ENST00000374877.3_Missense_Mutation_p.R351H|CCDC40_ENST00000269318.5_Missense_Mutation_p.R351H|CCDC40_ENST00000374876.4_Missense_Mutation_p.R351H	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	351					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTCACGACCGCCACGCAATG	0.657000													17	44					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31318530	31318530	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr18:31318530G>T	ENST00000269197.5	+	11	1162	c.1162G>T	c.(1162-1164)Ggg>Tgg	p.G388W		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TTCTTCATGTGGGACTTCTGG	0.478000													15	33					2.31682e-05	2.46894e-05	1	1	0
PRLR	5618	broad.mit.edu	37	5	35072844	35072844	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:35072844G>C	ENST00000382002.5	-	6	802	c.376C>G	c.(376-378)Cag>Gag	p.Q126E	PRLR_ENST00000397391.3_Missense_Mutation_p.Q55E|PRLR_ENST00000348262.3_Missense_Mutation_p.Q126E|PRLR_ENST00000342362.5_Missense_Mutation_p.Q25E|PRLR_ENST00000310101.5_Missense_Mutation_p.Q126E|PRLR_ENST00000231423.3_Missense_Mutation_p.Q126E|PRLR_ENST00000509934.1_5'UTR|PRLR_ENST00000513753.1_Missense_Mutation_p.Q126E|PRLR_ENST00000542609.1_Missense_Mutation_p.Q126E|PRLR_ENST00000511486.1_Missense_Mutation_p.Q25E	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	126					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GGGTCTGGCTGAACTGCAGAA	0.428000													23	49					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61539354	61539354	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:61539354C>T	ENST00000278836.5	+	7	1141	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*	MYRF_ENST00000265460.5_Nonsense_Mutation_p.Q340*|TMEM258_ENST00000535042.1_Intron	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		CCCCAACTACCAGTCCATCAA	0.602000													39	96					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23299928	23299928	+	RNA	SNP	C	C	T	rs142794095	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:23299928C>T	ENST00000560464.1	-	0	4359																											GCAAGCCGGACGCATTCCCGG	0.572000													3	30					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322473	79322473	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:79322473G>A	ENST00000428286.1	-	8	4840	c.3640C>T	c.(3640-3642)Caa>Taa	p.Q1214*	PRUNE2_ENST00000376718.3_Nonsense_Mutation_p.Q1573*			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1573					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CAGTTGCCTTGGTTTTCTTCT	0.423000													11	74					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164468152	164468152	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:164468152C>T	ENST00000333129.3	-	3	504	c.190G>A	c.(190-192)Gca>Aca	p.A64T	FIGN_ENST00000409634.1_Intron|FIGN_ENST00000482917.1_5'UTR	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	64						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						AGGTTGGATGCAGTCAGAGCA	0.502000													6	150					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17306179	17306179	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:17306179G>A	ENST00000595618.1	+	22	4095	c.3943G>A	c.(3943-3945)Ggc>Agc	p.G1315S	MYO9B_ENST00000397274.2_Missense_Mutation_p.G1315S|MYO9B_ENST00000594824.1_Missense_Mutation_p.G1315S	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1315	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						ACTGTGGCGGGGCAAGAAGCT	0.706000													14	71					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52661591	52661591	+	Splice_Site	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:52661591C>T	ENST00000355568.4	-	15	1415		c.e15-1			NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5								ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GACGAAGACCCTATTTATTGA	0.343000													57	50					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26619920	26619920	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:26619920T>A	ENST00000256737.3	+	15	2308	c.1456T>A	c.(1456-1458)Ttc>Atc	p.F486I	ANO3_ENST00000531568.1_Missense_Mutation_p.F340I|ANO3_ENST00000525139.1_Missense_Mutation_p.F470I|ANO3_ENST00000537978.1_Missense_Mutation_p.F470I	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	486						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						AGCCACAGTCTTCCTGGAGTT	0.318000													10	52					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140707501	140707501	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:140707501G>T	ENST00000460843.1	+	20	2938	c.2911G>T	c.(2911-2913)Gaa>Taa	p.E971*		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	971					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AAAGAACAAGGAAGGAGAGAC	0.512000													48	123					1.81118e-26	2.23485e-26	1	1	0
KLC3	147700	broad.mit.edu	37	19	45851307	45851307	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:45851307A>G	ENST00000470402.1	+	4	810	c.710A>G	c.(709-711)tAt>tGt	p.Y237C	KLC3_ENST00000585434.1_Missense_Mutation_p.Y222C|KLC3_ENST00000391946.2_Missense_Mutation_p.Y223C			Q6P597	KLC3_HUMAN	kinesin light chain 3	223						cytoplasm|kinesin complex|microtubule	microtubule motor activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CAGGGCCGCTATGAGGTGGCG	0.677000													7	10					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33795625	33795625	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr18:33795625G>A	ENST00000261326.5	+	8	1503	c.1482G>A	c.(1480-1482)ggG>ggA	p.G494G		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	494					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	ACTCATCAGGGGACTGGCCTG	0.552000													4	56					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39920973	39920973	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:39920973T>C	ENST00000393931.3	-	7	1268	c.1150A>G	c.(1150-1152)Acc>Gcc	p.T384A	JUP_ENST00000393930.1_Missense_Mutation_p.T384A|JUP_ENST00000310706.5_Missense_Mutation_p.T384A|JUP_ENST00000540235.1_Intron	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	384					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		ACCTGCTTGGTGGCCACATCT	0.642000													35	53					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113220821	113220821	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:113220821G>A	ENST00000401783.2	-	20	3842	c.3506C>T	c.(3505-3507)gCg>gTg	p.A1169V	SVEP1_ENST00000374469.1_Missense_Mutation_p.A1146V|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.A1169V	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1169					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding	p.A1169V(1)		NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTCCTCTGCCGCTGAGAAAGT	0.393000													7	13					0	0	1	0	0
NPFF	8620	broad.mit.edu	37	12	53901159	53901159	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:53901159C>T	ENST00000267017.3	-	1	263	c.100G>A	c.(100-102)Gcg>Acg	p.A34T	RP11-793H13.10_ENST00000591834.1_Intron	NM_003717.2	NP_003708.1	O15130	NPFF_HUMAN	neuropeptide FF-amide peptide precursor	34					neuropeptide signaling pathway|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|prostate(1)|urinary_tract(1)	3						ACACTCACCGCGGAGAGCTGG	0.557000													7	82					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201618544	201618544	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:201618544C>T	ENST00000367296.4	+	1	1168	c.748C>T	c.(748-750)Cag>Tag	p.Q250*	NAV1_ENST00000367302.1_Nonsense_Mutation_p.Q263*|NAV1_ENST00000295624.6_Nonsense_Mutation_p.Q250*|NAV1_ENST00000367300.3_Nonsense_Mutation_p.Q250*|NAV1_ENST00000367297.4_Nonsense_Mutation_p.Q250*	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	250					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GCTCTTCAGCCAGATGCTGGG	0.677000													3	6					0	0	1	0	0
COG6	57511	broad.mit.edu	37	13	40325082	40325082	+	Splice_Site	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:40325082G>C	ENST00000455146.3	+	19	1876		c.e19-1		COG6_ENST00000416691.1_Intron	NM_020751.2	NP_065802.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6						protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		CTTATCAATAGAGAGCAGATC	0.333000													3	35					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61471965	61471965	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr20:61471965G>C	ENST00000343916.3	+	32	1939	c.1936G>C	c.(1936-1938)Gat>Cat	p.D646H	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	646	Triple-helical region 1 (COL1).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GCCTCCCGGAGATCCTGGGCT	0.672000													18	25					0	0	1	0	0
POU4F1	5457	broad.mit.edu	37	13	79176022	79176022	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:79176022G>A	ENST00000377208.5	-	2	999	c.788C>T	c.(787-789)aCg>aTg	p.T263M	RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000430549.2_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	263	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GCGCGGGTCCGTGTCCGAGTC	0.776000													6	9					0	0	1	0	0
IGLV5-37	28783	broad.mit.edu	37	22	22782197	22782197	+	RNA	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:22782197C>G	ENST00000390300.2	+	0	200																											GGAGCCCTCCCAGGTATCTCC	0.542000													5	143					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26443684	26443684	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:26443684G>T	ENST00000265944.5	+	25	2891	c.2725G>T	c.(2725-2727)Gga>Tga	p.G909*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	909	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GGGCGACACTGGAGAAGCCAC	0.403000													21	28					1.85244e-09	2.06807e-09	1	1	0
C11orf30	56946	broad.mit.edu	37	11	76255458	76255458	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:76255458C>T	ENST00000529032.1	+	18	2865	c.2865C>T	c.(2863-2865)agC>agT	p.S955S	C11orf30_ENST00000334736.3_Silent_p.S955S|C11orf30_ENST00000524490.1_Silent_p.S857S|C11orf30_ENST00000525919.1_Silent_p.S956S|C11orf30_ENST00000525038.1_Silent_p.S956S|C11orf30_ENST00000524767.1_Silent_p.S970S|C11orf30_ENST00000533248.1_Silent_p.S864S|C11orf30_ENST00000343878.3_Silent_p.S955S			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	955	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AGAAACTTAGCCAGCCCCCGC	0.532000													40	44					0	0	1	0	0
ZFP1	162239	broad.mit.edu	37	16	75204063	75204063	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr16:75204063A>G	ENST00000393430.2	+	4	1179	c.1055A>G	c.(1054-1056)tAt>tGt	p.Y352C	ZFP1_ENST00000568079.1_3'UTR|ZFP1_ENST00000332307.4_Missense_Mutation_p.Y319C|ZFP1_ENST00000464850.1_3'UTR|ZFP1_ENST00000570010.1_Missense_Mutation_p.Y352C			Q6P2D0	ZFP1_HUMAN	ZFP1 zinc finger protein	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	12						GAGAAACCCTATGAATGTACT	0.443000													9	98					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48073587	48073587	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:48073587G>A	ENST00000264316.4	-	14	1547	c.1462C>T	c.(1462-1464)Cct>Tct	p.P488S	TXK_ENST00000507351.1_Missense_Mutation_p.P143S	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	488	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						GCCAGGTGAGGGCGATATAGC	0.418000													97	78					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138655203	138655203	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:138655203C>T	ENST00000251691.4	+	33	5386	c.5220C>T	c.(5218-5220)ccC>ccT	p.P1740P		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1740					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCAAAGGCCCCTCTCCTGGAG	0.478000													36	35					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072357	134072357	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:134072357C>T	ENST00000264360.4	+	1	1888	c.1062C>T	c.(1060-1062)aaC>aaT	p.N354N		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	354	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTAATGACAACGCGCCAGAGA	0.627000													48	30					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16091177	16091177	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:16091177G>T	ENST00000332432.8	-	3	906	c.707C>A	c.(706-708)tCt>tAt	p.S236Y	MARCH11_ENST00000505509.1_5'UTR	NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	236						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						CAGTGTTATAGAAATGCTCTG	0.393000													6	8					5.9392e-07	6.52693e-07	1	1	0
TP53	7157	broad.mit.edu	37	17	7578239	7578239	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:7578239C>A	ENST00000420246.2	-	6	742	c.610G>T	c.(610-612)Gag>Tag	p.E204*	TP53_ENST00000413465.2_Nonsense_Mutation_p.E204*|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Nonsense_Mutation_p.E204*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E204*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E204*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E204*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	204	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		E -> A (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|VE -> LV (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E204*(33)|p.0?(8)|p.?(5)|p.E72*(3)|p.E111*(3)|p.E204K(2)|p.E204fs*43(2)|p.E204Q(1)|p.E204fs*4(1)|p.V203_E204>V*(1)|p.V203_E204>LV(1)|p.E204fs*39(1)|p.G199fs*42(1)|p.E204_N210delEYLDDRN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCAAATACTCCACACGCAAA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	19					8.16721e-17	9.73605e-17	1	1	0
NOTCH1	4851	broad.mit.edu	37	9	139395258	139395258	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:139395258C>T	ENST00000277541.6	-	31	5755	c.5680G>A	c.(5680-5682)Ggc>Agc	p.G1894S		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1894					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCTCCAGGCCGCCCCCGCTG	0.682000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			26	24					0	0	1	0	0
EXOC6B	23233	broad.mit.edu	37	2	72740282	72740282	+	Silent	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:72740282G>T	ENST00000272427.6	-	11	1276	c.1146C>A	c.(1144-1146)atC>atA	p.I382I	EXOC6B_ENST00000410104.1_Silent_p.I382I	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	382					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						GGAGTGCTGCGATGGTTTTTG	0.388000													25	35					5.35356e-11	6.00851e-11	1	1	0
SLC26A3	1811	broad.mit.edu	37	7	107414497	107414497	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:107414497C>T	ENST00000340010.5	-	17	2059	c.1875G>A	c.(1873-1875)ctG>ctA	p.L625L	SLC26A3_ENST00000422236.2_Intron	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	625	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGTGGAAAGGCAGGTCTGTGG	0.433000													8	165					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76326776	76326776	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:76326776G>T	ENST00000312916.7	+	1	567	c.185G>T	c.(184-186)aGc>aTc	p.S62I	AGGF1_ENST00000503538.1_Intron|AGGF1_ENST00000506806.1_Missense_Mutation_p.S62I	NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	62					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		AACGCAGAAAGCAACAACCAG	0.637000													30	12					2.61193e-14	3.06176e-14	1	1	0
MAPT	4137	broad.mit.edu	37	17	44039726	44039726	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:44039726T>C	ENST00000344290.5	+	2	345	c.23T>C	c.(22-24)tTc>tCc	p.F8S	MAPT_ENST00000574436.1_Missense_Mutation_p.F8S|MAPT_ENST00000571987.1_Missense_Mutation_p.F8S|MAPT_ENST00000570299.1_3'UTR|MAPT_ENST00000535772.1_Missense_Mutation_p.F8S|MAPT_ENST00000446361.3_Missense_Mutation_p.F8S|MAPT_ENST00000420682.2_Missense_Mutation_p.F8S|MAPT_ENST00000415613.2_Missense_Mutation_p.F8S|MAPT_ENST00000351559.5_Missense_Mutation_p.F8S|MAPT_ENST00000347967.5_5'UTR|MAPT_ENST00000340799.5_Missense_Mutation_p.F8S|MAPT_ENST00000334239.8_Missense_Mutation_p.F8S|MAPT_ENST00000262410.5_Missense_Mutation_p.F8S|MAPT_ENST00000431008.3_Missense_Mutation_p.F8S	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	8					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CGCCAGGAGTTCGAAGTGATG	0.577000													49	10					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197349091	197349091	+	RNA	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:197349091G>A	ENST00000418868.1	-	0	486					NR_003266.2																						GCTCCGTCACGTAGTGGATGG	0.582000													5	74					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376947	138376947	+	Silent	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:138376947C>A	ENST00000356818.2	+	4	1140	c.591C>A	c.(589-591)ggC>ggA	p.G197G	PPP1R26_ENST00000605286.1_Silent_p.G197G|PPP1R26_ENST00000604351.1_Silent_p.G197G|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Silent_p.G197G|PPP1R26_ENST00000605660.1_Silent_p.G197G	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	197						nucleolus	protein binding										CAGGTGGTGGCCCCGGCAGCC	0.652000													6	105					0.0215528	0.0218636	1	1	0
ZFYVE1	53349	broad.mit.edu	37	14	73440836	73440836	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr14:73440836C>T	ENST00000556143.1	-	11	2773	c.2053G>A	c.(2053-2055)Gtg>Atg	p.V685M	ZFYVE1_ENST00000553891.1_Missense_Mutation_p.V685M|ZFYVE1_ENST00000394207.2_Missense_Mutation_p.V270M|ZFYVE1_ENST00000318876.5_Missense_Mutation_p.V671M|ZFYVE1_ENST00000555072.1_Missense_Mutation_p.V270M	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	685						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		GTGTTCTGCACGGCCTCGCCC	0.557000													25	109					0	0	1	0	0
CCDC50	152137	broad.mit.edu	37	3	191047497	191047497	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:191047497C>T	ENST00000392455.3	+	1	632	c.34C>T	c.(34-36)Cct>Tct	p.P12S	UTS2B_ENST00000340524.5_Intron|CCDC50_ENST00000392456.3_Missense_Mutation_p.P12S	NM_174908.3	NP_777568.1	Q8IVM0	CCD50_HUMAN	coiled-coil domain containing 50	12						cytoplasm	protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|stomach(1)	23	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		GTCCAAGCTGCCTGGAGTCAA	0.692000													28	13					0	0	1	0	0
RNF148	378925	broad.mit.edu	37	7	122342525	122342525	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:122342525T>A	ENST00000434824.1	-	1	496	c.280A>T	c.(280-282)Agg>Tgg	p.R94W	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|RNF148_ENST00000447240.1_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	94	PA.					integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						TGTTTGGGCCTGCTGAAATTG	0.507000													69	105					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56950010	56950010	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:56950010G>A	ENST00000497933.1	+	1	790	c.643G>A	c.(643-645)Ggg>Agg	p.G215R		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	185	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CCTCAGTTATGGGGGCCTGGC	0.647000													26	44					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43702201	43702201	+	Silent	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:43702201T>A	ENST00000405312.3	-	3	894	c.657A>T	c.(655-657)atA>atT	p.I219I	PSG4_ENST00000244295.9_Silent_p.I219I|PSG4_ENST00000433626.2_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	219	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CTGGGTTCCGTATTTCACATT	0.507000													23	135					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66802276	66802276	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:66802276G>T	ENST00000393946.2	+	6	1357	c.195G>T	c.(193-195)aaG>aaT	p.K65N	SYT12_ENST00000527043.1_Missense_Mutation_p.K65N|SYT12_ENST00000525457.1_Missense_Mutation_p.K65N|SYT12_ENST00000526281.1_Intron			Q8IV01	SYT12_HUMAN	synaptotagmin XII	65						cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						TTCAGCAGAAGTACGGCGAGA	0.607000													19	68					5.26018e-13	6.06501e-13	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1087063	1087063	+	Silent	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:1087063C>A	ENST00000264930.5	-	6	673	c.630G>T	c.(628-630)acG>acT	p.T210T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	210					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCCCTGCAAACGTCGTGCCCA	0.572000													31	55					2.68265e-12	3.04322e-12	1	1	0
OR8K3	219473	broad.mit.edu	37	11	56086206	56086206	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:56086206C>G	ENST00000312711.1	+	1	424	c.424C>G	c.(424-426)Cag>Gag	p.Q142E		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					AAGGGTATGTCAGGTGCTGGT	0.418000													45	52					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1254215	1254215	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr16:1254215C>T	ENST00000348261.5	+	10	2456	c.2208C>T	c.(2206-2208)caC>caT	p.H736H	CACNA1H_ENST00000358590.4_Silent_p.H736H|CACNA1H_ENST00000565831.1_Silent_p.H736H	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	736					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity	p.H736H(1)		breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACGTCCGGCACGGTGACCGCT	0.716000													5	25					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55464538	55464538	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:55464538A>T	ENST00000394600.3	-	16	2633	c.1897T>A	c.(1897-1899)Tct>Act	p.S633T	MTIF2_ENST00000403721.1_Missense_Mutation_p.S633T|MTIF2_ENST00000263629.4_Missense_Mutation_p.S633T	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	633					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						TCTGTTACAGAGAAGGTAGCT	0.368000													28	59					0	0	1	0	0
NHP2L1	4809	broad.mit.edu	37	22	42071074	42071074	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:42071074G>A	ENST00000401959.1	-	4	566	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C	NHP2L1_ENST00000215956.5_Missense_Mutation_p.R84C|NHP2L1_ENST00000355257.3_Missense_Mutation_p.R84C|NHP2L1_ENST00000402458.1_Missense_Mutation_p.R88C|NHP2L1_ENST00000463675.1_5'UTR	NM_005008.3	NP_004999.1	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	84					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding			endometrium(1)|kidney(1)|lung(1)|prostate(1)	4						TGCTTGGAGCGCACAAACACG	0.577000													4	119					0	0	1	0	0
SPINK4	27290	broad.mit.edu	37	9	33221053	33221053	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:33221053A>T	ENST00000379725.1	+	2	199	c.77A>T	c.(76-78)gAt>gTt	p.D26V	SPINK4_ENST00000379723.1_Missense_Mutation_p.D26V			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	0						extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			CTGCTGGGGGATGCTTCGCAC	0.522000													26	7					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105180723	105180723	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr14:105180723G>A	ENST00000392634.4	+	21	3336	c.3224G>A	c.(3223-3225)cGt>cAt	p.R1075H	INF2_ENST00000330634.7_Missense_Mutation_p.R1075H	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	1075					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGGAGAGGCGTTCTTCCTGG	0.672000													14	2					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74320729	74320729	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:74320729C>A	ENST00000409262.3	+	7	2798	c.2798C>A	c.(2797-2799)gCc>gAc	p.A933D		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	933							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGGGTCACGGCCTGCATGGAC	0.607000													69	56					2.19297e-23	2.65929e-23	1	1	0
KCNF1	3754	broad.mit.edu	37	2	11053470	11053470	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:11053470C>G	ENST00000295082.1	+	1	1408	c.918C>G	c.(916-918)caC>caG	p.H306Q		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	306						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		TGGCCCGCCACTCCTCGGGCC	0.637000													16	56					0	0	1	0	0
PON2	5445	broad.mit.edu	37	7	95034721	95034721	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:95034721C>T	ENST00000536183.1	-	9	1232	c.1049G>A	c.(1048-1050)gGa>gAa	p.G350E	PON2_ENST00000222572.3_Missense_Mutation_p.G329E|PON2_ENST00000483292.1_5'UTR|PON2_ENST00000433091.2_Missense_Mutation_p.G317E	NM_000305.2	NP_000296.2	Q15165	PON2_HUMAN	paraoxonase 2	329					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			TACAGAACTTCCTTGGAGAAC	0.428000													9	102					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102293008	102293008	+	RNA	SNP	A	A	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:102293008A>C	ENST00000561463.1	+	0	1054																		p.K171E(1)									GCGTGGGAACAAGAAGACACT	0.582000													3	43					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64975341	64975341	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:64975341C>G	ENST00000399262.2	-	6	1012	c.794G>C	c.(793-795)cGt>cCt	p.R265P	JMJD1C_ENST00000399251.1_Missense_Mutation_p.R46P|JMJD1C_ENST00000402544.1_Missense_Mutation_p.R46P|JMJD1C_ENST00000489372.2_5'UTR|JMJD1C_ENST00000542921.1_Missense_Mutation_p.R83P	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	265					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTGATTGGCACGAGACCTGCG	0.368000													26	64					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48806100	48806100	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:48806100C>T	ENST00000315396.7	-	10	1662	c.980G>A	c.(979-981)aGc>aAc	p.S327N		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	327										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GGCACGTGCGCTCACCAAAGC	0.617000													59	25					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71729878	71729878	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:71729878T>C	ENST00000393695.3	-	10	1064	c.733A>G	c.(733-735)Acc>Gcc	p.T245A	NUMA1_ENST00000351960.6_Missense_Mutation_p.T245A|RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000358965.6_Missense_Mutation_p.T245A	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	245					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CCCTTCTCGGTGAGGAGCTTG	0.577000			T	RARA	APL								26	60					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038093	75038093	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:75038093C>G	ENST00000326665.5	-	14	3519	c.3301G>C	c.(3301-3303)Gaa>Caa	p.E1101Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1101	Glu-rich.			E -> G (in Ref. 4; BAC86994).						NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCCCTTCTTCCGCTTTAAGT	0.453000													4	118					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52941979	52941979	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:52941979G>A	ENST00000267119.5	-	5	1004	c.935C>T	c.(934-936)gCc>gTc	p.A312V		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	312	Coil 2.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		ACTCTTCAAGGCAATCTCCTC	0.577000													40	67					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120840149	120840149	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:120840149G>A	ENST00000369144.3	-	1	167	c.40C>T	c.(40-42)Cgc>Tgc	p.R14C	EIF3A_ENST00000478852.1_5'UTR	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	14					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CCGTTGGCGCGTTTGAGGGCA	0.706000													13	10					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117122372	117122372	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:117122372G>A	ENST00000369486.3	-	10	3741	c.2976C>T	c.(2974-2976)tcC>tcT	p.S992S	IGSF3_ENST00000318837.6_Silent_p.S1012S|IGSF3_ENST00000369483.1_Silent_p.S1012S	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	992	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TAGTCCTCAGGGAATACCAGG	0.612000													8	49					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3613872	3613872	+	RNA	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr16:3613872G>A	ENST00000301749.7	-	0	1471				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTCCTCGGGGGCCACAGCTCT	0.662000													39	68					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60895706	60895706	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr20:60895706A>C	ENST00000252999.3	-	50	6734	c.6668T>G	c.(6667-6669)cTg>cGg	p.L2223R		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2223	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding	p.L2223R(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGGGGGCCCAGGGGGCTCCG	0.706000													5	15					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593930	135593930	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chrX:135593930T>A	ENST00000535601.1	+	10	2448	c.2026T>A	c.(2026-2028)Tca>Aca	p.S676T	HTATSF1_ENST00000218364.4_Missense_Mutation_p.S676T	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	676	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding	p.S676A(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					GTTTGAAGAGTCAGATGACAA	0.403000													8	82					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732928	88732928	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:88732928G>C	ENST00000226284.5	+	7	887	c.820G>C	c.(820-822)Gga>Cga	p.G274R		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	274					biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		ATACGACAATGGATATGAAAT	0.473000													8	70					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682838	47682838	+	Silent	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:47682838T>A	ENST00000283303.2	+	6	2115	c.1857T>A	c.(1855-1857)ggT>ggA	p.G619G	GPR115_ENST00000371220.1_Silent_p.G676G|GPR115_ENST00000327753.3_Silent_p.G619G	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	619					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						TGACCTGGGGTTTTGGAATAG	0.463000													6	167					0	0	1	0	0
HIST1H2AI	8329	broad.mit.edu	37	6	27775992	27775992	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:27775992C>T	ENST00000358739.3	+	1	94	c.5C>T	c.(4-6)tCt>tTt	p.S2F		NM_003509.2	NP_003500.1			histone cluster 1, H2ai											lung(3)	3						TTTGCCATGTCTGGGCGTGGC	0.542000													108	77					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120809388	120809388	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:120809388C>T	ENST00000369144.3	-	17	2710	c.2583G>A	c.(2581-2583)agG>agA	p.R861R	EIF3A_ENST00000541549.1_Silent_p.R827R|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	861	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTTCCAACTCCCTTTGGCGTT	0.458000													84	159					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70713123	70713123	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:70713123G>A	ENST00000229195.3	+	4	796	c.217G>A	c.(217-219)Gca>Aca	p.A73T	CNOT2_ENST00000418359.3_Missense_Mutation_p.A73T	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	73					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			TCAGTTTGGGGCAAGTTTATA	0.338000													15	50					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43420415	43420415	+	Nonsense_Mutation	SNP	G	G	A	rs112289603	byFrequency	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:43420415G>A	ENST00000601833.1	-	2	1359	c.76C>T	c.(76-78)Cga>Tga	p.R26*	PSG6_ENST00000402603.4_Nonsense_Mutation_p.R97*|PSG6_ENST00000292125.2_Nonsense_Mutation_p.R97*|PSG6_ENST00000187910.2_Nonsense_Mutation_p.R97*					pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				ACTGTTTCTCGTCCACTGTAG	0.458000													28	465					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186978640	186978640	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:186978640T>A	ENST00000337774.5	-	4	825	c.436A>T	c.(436-438)Agg>Tgg	p.R146W	MASP1_ENST00000392470.2_Missense_Mutation_p.R120W|MASP1_ENST00000169293.6_Missense_Mutation_p.R146W|MASP1_ENST00000392472.2_Missense_Mutation_p.R33W|MASP1_ENST00000296280.6_Missense_Mutation_p.R146W|MASP1_ENST00000495249.1_Intron	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	146	EGF-like; calcium-binding.|Homodimerization (By similarity).|Interaction with FCN2.|Interaction with MBL2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TCGTCCTCCCTCTCCTTGCAC	0.507000													138	58					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1021358	1021358	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:1021358G>A	ENST00000448924.1	-	8	884	c.453C>T	c.(451-453)ggC>ggT	p.G151G	C1orf159_ENST00000437760.1_Silent_p.G115G|C1orf159_ENST00000421241.2_Silent_p.G115G|C1orf159_ENST00000482816.1_5'UTR|C1orf159_ENST00000294576.5_Silent_p.G115G|C1orf159_ENST00000379319.1_Silent_p.G115G|C1orf159_ENST00000379320.1_Silent_p.G115G|C1orf159_ENST00000379339.1_Silent_p.G151G			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	151						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TGAAGAACGTGCCCAGGAAGA	0.637000													5	30					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179558368	179558368	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:179558368G>A	ENST00000589042.1	-	119	31786	c.31562C>T	c.(31561-31563)gCc>gTc	p.A10521V	TTN_ENST00000342992.6_Missense_Mutation_p.A9277V|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A10204V|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10204	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGAAATGGCAACGTGAAT	0.308000													15	1					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108373054	108373054	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:108373054G>A	ENST00000361582.3	+	19	2326	c.2096G>A	c.(2095-2097)aGt>aAt	p.S699N	DZIP3_ENST00000463306.1_Missense_Mutation_p.S699N	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	699					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CACTCAGTCAGTAGACTTATA	0.388000													52	65					0	0	1	0	0
STS	412	broad.mit.edu	37	X	7252104	7252104	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chrX:7252104A>G	ENST00000217961.4	+	9	1554	c.1334A>G	c.(1333-1335)tAc>tGc	p.Y445C		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	445					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTCTTCCATTACTGCAACGCC	0.507000									Ichthyosis				41	12					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060646	9060646	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:9060646G>T	ENST00000397910.4	-	3	27003	c.26800C>A	c.(26800-26802)Ctt>Att	p.L8934I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8936	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTTCTGAAAGCTGAATTGCC	0.488000													118	261					3.26844e-40	4.12958e-40	1	1	0
KALRN	8997	broad.mit.edu	37	3	124103805	124103805	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:124103805C>T	ENST00000360013.3	+	11	2005	c.1878C>T	c.(1876-1878)atC>atT	p.I626I	KALRN_ENST00000240874.3_Silent_p.I626I|KALRN_ENST00000460856.1_Silent_p.I626I	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	626					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGGTGCGCATCCAAGACTTCG	0.572000													54	75					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64434817	64434817	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:64434817T>A	ENST00000265459.6	-	9	2164	c.1703A>T	c.(1702-1704)gAc>gTc	p.D568V	NRXN2_ENST00000377559.3_Missense_Mutation_p.D537V|NRXN2_ENST00000377551.1_Missense_Mutation_p.D568V|NRXN2_ENST00000409571.1_Missense_Mutation_p.D561V	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	568	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AGATCCCATGTCCAGCAGAAG	0.627000													27	85					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585100	82585100	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:82585100G>A	ENST00000423517.2	-	5	5506	c.5169C>T	c.(5167-5169)tcC>tcT	p.S1723S	PCLO_ENST00000333891.8_Silent_p.S1723S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1654					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGTGAAGCTGGAAGCATGCA	0.478000													51	39					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21732143	21732143	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:21732143G>A	ENST00000314759.5	-	7	1161	c.1037C>T	c.(1036-1038)tCa>tTa	p.S346L	SKA3_ENST00000400018.3_Missense_Mutation_p.S346L	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	346					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						AATCGTAGGTGAAGAGGGATC	0.358000													29	82					0	0	1	0	0
FTSJ2	29960	broad.mit.edu	37	7	2275060	2275060	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:2275060C>T	ENST00000242257.8	-	3	466	c.438G>A	c.(436-438)agG>agA	p.R146R	FTSJ2_ENST00000440306.2_3'UTR|FTSJ2_ENST00000486040.1_5'UTR|FTSJ2_ENST00000407040.1_Silent_p.R52R	NM_013393.1	NP_037525.1	Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	146					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CATCTGCTCTCCTGCCAGGAA	0.567000													60	58					0	0	1	0	0
TOMM40L	84134	broad.mit.edu	37	1	161197105	161197105	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:161197105G>T	ENST00000367988.3	+	4	510	c.241G>T	c.(241-243)Gcc>Tcc	p.A81S	TOMM40L_ENST00000545897.1_Missense_Mutation_p.A81S|TOMM40L_ENST00000367987.1_Missense_Mutation_p.A81S|TOMM40L_ENST00000474486.1_Intron	NM_032174.4	NP_115550.2	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	81					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(2)|liver(4)|lung(4)	10	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCTCCATGCGGCCTATGCAGG	0.567000											OREG0013943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	53					9.65021e-13	1.10065e-12	1	1	0
FAM208B	54906	broad.mit.edu	37	10	5788805	5788805	+	Silent	SNP	T	T	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr10:5788805T>C	ENST00000328090.5	+	15	4046	c.3421T>C	c.(3421-3423)Tta>Cta	p.L1141L		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1141																	AGTGTGTTCATTACAGAAGGA	0.463000													61	99					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21829342	21829342	+	Silent	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr14:21829342G>T	ENST00000216297.2	-	16	2162	c.1824C>A	c.(1822-1824)ccC>ccA	p.P608P		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	608					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TCTGTTCTCCGGGTGCCTTAA	0.378000													74	34					7.25294e-45	9.2191e-45	1	1	0
H3F3B	3021	broad.mit.edu	37	17	73775146	73775146	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:73775146T>A	ENST00000254810.4	-	2	242	c.110A>T	c.(109-111)aAg>aTg	p.K37M	H3F3B_ENST00000593254.1_Intron|H3F3B_ENST00000592643.1_Missense_Mutation_p.K37M|H3F3B_ENST00000586607.1_Missense_Mutation_p.K37M|H3F3B_ENST00000591890.1_Missense_Mutation_p.K37M|H3F3B_ENST00000589599.1_Missense_Mutation_p.K37M|H3F3B_ENST00000587560.1_Missense_Mutation_p.K37M	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	37					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATGAGGCTTCTTCACCCCGCC	0.662000											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	36					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13894567	13894567	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr20:13894567G>T	ENST00000284951.5	-	5	484	c.410C>A	c.(409-411)gCa>gAa	p.A137E	SEL1L2_ENST00000486903.1_5'UTR|SEL1L2_ENST00000378072.5_Missense_Mutation_p.A137E			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	137						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						CATGTCAGCTGCTTTGGCAAA	0.343000													31	53					9.65021e-13	1.10065e-12	1	1	0
GJA10	84694	broad.mit.edu	37	6	90605608	90605608	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:90605608C>G	ENST00000369352.1	+	1	1421	c.1421C>G	c.(1420-1422)aCt>aGt	p.T474S		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	474					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CCTTCAGTCACTGGGCACAGA	0.488000													67	94					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	C	G	rs143004725	by1000genomes	TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:12885059C>G	ENST00000535591.1	-	4	1247	c.1052G>C	c.(1051-1053)tGc>tCc	p.C351S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	351								p.C351S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGTGGCCATGCAGATGGGATT	0.532000													4	155					0	0	1	0	0
CDKN2D	1032	broad.mit.edu	37	19	10679283	10679283	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:10679283G>T	ENST00000393599.2	-	1	371	c.47C>A	c.(46-48)gCg>gAg	p.A16E	CDKN2D_ENST00000335766.2_Missense_Mutation_p.A16E	NM_001800.3|NM_079421.2	NP_001791.1|NP_524145.1	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	16					anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			endometrium(3)|lung(2)|ovary(1)	6			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			GCCCCGGGCCGCCGCCCCACT	0.746000													3	6					0.00909568	0.0093619	1	1	0
RFXAP	5994	broad.mit.edu	37	13	37399619	37399619	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:37399619G>A	ENST00000255476.2	+	2	789	c.655G>A	c.(655-657)Gat>Aat	p.D219N	RFXAP_ENST00000472888.1_3'UTR	NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	219	C-terminal domain.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ATCTTTTGGGGATCGTCCTGC	0.313000													25	49					0	0	1	0	0
VPS18	57617	broad.mit.edu	37	15	41191868	41191868	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:41191868C>T	ENST00000220509.5	+	4	1191	c.852C>T	c.(850-852)ttC>ttT	p.F284F	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	284					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CCCGGGCCTTCGCCTGGATGA	0.637000													41	116					0	0	1	0	0
NAAA	27163	broad.mit.edu	37	4	76841945	76841945	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:76841945C>T	ENST00000286733.4	-	7	949	c.848G>A	c.(847-849)cGa>cAa	p.R283Q	NAAA_ENST00000505594.1_Missense_Mutation_p.R182Q|NAAA_ENST00000399497.3_Missense_Mutation_p.R283Q|NAAA_ENST00000511606.1_5'UTR|NAAA_ENST00000507956.1_Missense_Mutation_p.R283Q	NM_014435.3	NP_055250.2	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase	283					lipid metabolic process	lysosome	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	11						TGTCTCAACTCGGAACCACCT	0.443000													10	113					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1021359	1021359	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:1021359C>A	ENST00000448924.1	-	8	883	c.452G>T	c.(451-453)gGc>gTc	p.G151V	C1orf159_ENST00000437760.1_Missense_Mutation_p.G115V|C1orf159_ENST00000421241.2_Missense_Mutation_p.G115V|C1orf159_ENST00000482816.1_5'UTR|C1orf159_ENST00000294576.5_Missense_Mutation_p.G115V|C1orf159_ENST00000379319.1_Missense_Mutation_p.G115V|C1orf159_ENST00000379320.1_Missense_Mutation_p.G115V|C1orf159_ENST00000379339.1_Missense_Mutation_p.G151V			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	151						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GAAGAACGTGCCCAGGAAGAG	0.637000													5	30					3.59834e-05	3.81532e-05	1	1	0
ZNF425	155054	broad.mit.edu	37	7	148801826	148801826	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:148801826C>T	ENST00000378061.2	-	4	1269	c.1137G>A	c.(1135-1137)acG>acA	p.T379T		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	379					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCTCGCTGTGCGTCCTCTGGT	0.567000													10	216					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365622	13365622	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:13365622C>T	ENST00000379287.3	-	2	1190	c.526G>A	c.(526-528)Gtg>Atg	p.V176M	GFOD1_ENST00000379284.1_Missense_Mutation_p.V73M	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	176						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			TAGGTGCCCACGGAGTGCAGG	0.632000													33	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613753	179613753	+	Silent	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:179613753A>G	ENST00000360870.5	-	46	13596	c.13374T>C	c.(13372-13374)caT>caC	p.H4458H	TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	586	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGATAATTCTATGCTTCACCT	0.343000													54	15					0	0	1	0	0
PSPH	5723	broad.mit.edu	37	7	56085002	56085002	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:56085002C>T	ENST00000395471.3	-	6	1151	c.346G>A	c.(346-348)Gta>Ata	p.V116I	PSPH_ENST00000275605.3_Missense_Mutation_p.V116I|PSPH_ENST00000459834.1_Intron			P78330	SERB_HUMAN	phosphoserine phosphatase	116					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity	p.V116I(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACATGCTCTACAATACTCCTA	0.393000													6	420					0	0	1	0	0
TMEM107	84314	broad.mit.edu	37	17	8077910	8077910	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:8077910G>A	ENST00000316425.5	-	4	411	c.299C>T	c.(298-300)tCc>tTc	p.S100F	TMEM107_ENST00000533070.1_Missense_Mutation_p.S100F|TMEM107_ENST00000437139.2_Missense_Mutation_p.S94F|TMEM107_ENST00000431792.2_Intron|TMEM107_ENST00000532998.1_3'UTR|TMEM107_ENST00000449985.2_Intron	NM_032354.3	NP_115730.2	Q6UX40	TM107_HUMAN	transmembrane protein 107	94						integral to membrane				large_intestine(1)|lung(4)|ovary(1)	6						CAGGGCCACGGATGCACTACA	0.507000													108	40					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141974875	141974875	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:141974875G>T	ENST00000359370.6	-	4	527	c.448C>A	c.(448-450)Ctg>Atg	p.L150M	FGF1_ENST00000337706.2_Missense_Mutation_p.L150M|FGF1_ENST00000378046.1_Missense_Mutation_p.L150M|FGF1_ENST00000494579.1_5'UTR|FGF1_ENST00000419524.2_Missense_Mutation_p.L150M|AC005592.2_ENST00000414314.1_RNA|AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000407758.1_3'UTR|FGF1_ENST00000360966.5_3'UTR	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	150					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	GAGACTGGCAGGGGGAGAAAC	0.498000													32	11					8.16721e-17	9.73605e-17	1	1	0
TIAM2	26230	broad.mit.edu	37	6	155578022	155578022	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:155578022C>G	ENST00000461783.3	+	29	6146	c.4873C>G	c.(4873-4875)Ccc>Gcc	p.P1625A	TIAM2_ENST00000456144.1_Missense_Mutation_p.P1654A|TIAM2_ENST00000529824.2_Missense_Mutation_p.P1654A|TIAM2_ENST00000367174.2_Missense_Mutation_p.P1001A|TIAM2_ENST00000275246.7_Missense_Mutation_p.P550A|TIAM2_ENST00000318981.5_Missense_Mutation_p.P1625A|TIAM2_ENST00000456877.2_Missense_Mutation_p.P937A|TIAM2_ENST00000528391.2_Missense_Mutation_p.P969A|TIAM2_ENST00000360366.4_Missense_Mutation_p.P1649A			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1625					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGGAGAGCAGCCCAAACTGGT	0.597000													36	37					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37411926	37411926	+	Splice_Site	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:37411926G>A	ENST00000373451.4	+	3	449	c.285_splice	c.e3+1	p.M95_splice		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		95	G-patch.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						AGAAGCTTATGGTATGTCAGC	0.438000													98	47					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99722114	99722114	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:99722114C>G	ENST00000393483.3	-	8	1101	c.257G>C	c.(256-258)tGt>tCt	p.C86S	TSGA10_ENST00000410001.1_Missense_Mutation_p.C86S|TSGA10_ENST00000542655.1_Missense_Mutation_p.C86S|TSGA10_ENST00000539964.1_Missense_Mutation_p.C86S|TSGA10_ENST00000355053.4_Missense_Mutation_p.C86S|TSGA10_ENST00000478090.1_5'UTR	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	86					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						AGGACTCTTACAGCTTTTCAT	0.393000													7	235					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57746271	57746271	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:57746271C>A	ENST00000269122.3	+	14	2536	c.2262C>A	c.(2260-2262)taC>taA	p.Y754*	CLTC_ENST00000393043.1_Nonsense_Mutation_p.Y754*|CLTC_ENST00000579456.1_Intron	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	754	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GCAACTGCTACGATCCTGAGC	0.408000			T	"""ALK, TFE3"""	"""ALCL, renal """								43	80					2.40228e-13	2.78506e-13	1	1	0
NCAM1	4684	broad.mit.edu	37	11	113075082	113075082	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:113075082C>T	ENST00000316851.7	+	2	172	c.172C>T	c.(172-174)Cgg>Tgg	p.R58W	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.R67W|NCAM1_ENST00000533760.1_5'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	68	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AAACCAGCAGCGGATCTCAGT	0.488000													15	16					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507514	155507514	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr4:155507514C>A	ENST00000302053.3	-	5	1145	c.1067G>T	c.(1066-1068)aGt>aTt	p.S356I	FGA_ENST00000403106.3_Missense_Mutation_p.S356I	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	356					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTTCCGGTACTACCAGGTCT	0.557000													62	30					3.37043e-27	4.1833e-27	1	1	0
CDH19	28513	broad.mit.edu	37	18	64176456	64176456	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr18:64176456C>A	ENST00000262150.2	-	11	1896	c.1604G>T	c.(1603-1605)aGa>aTa	p.R535I	CDH19_ENST00000540086.1_Intron	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	535	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				AAAACCAGTTCTATTAGTCAA	0.353000													14	51					0.000151284	0.000159605	1	1	0
GYG1	2992	broad.mit.edu	37	3	148727132	148727132	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:148727132C>T	ENST00000345003.4	+	5	851	c.551C>T	c.(550-552)cCg>cTg	p.P184L	GYG1_ENST00000484197.1_Missense_Mutation_p.P184L|GYG1_ENST00000483267.1_Intron|GYG1_ENST00000296048.6_Missense_Mutation_p.P184L|GYG1_ENST00000479119.1_3'UTR	NM_004130.3	NP_004121.2	P46976	GLYG_HUMAN	glycogenin 1	184					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AAACACCTGCCGTTTATTTAT	0.378000													5	345					0	0	1	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223833	142223833	+	RNA	SNP	C	C	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:142223833C>A	ENST00000390367.3	-	0	350																											AAGCTGCTGGCACAGAGATAC	0.532000													4	162					0.0215528	0.0218636	1	1	0
LOXL2	4017	broad.mit.edu	37	8	23198591	23198591	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr8:23198591G>T	ENST00000389131.3	-	4	1026	c.657C>A	c.(655-657)gaC>gaA	p.D219E	RP11-177H13.2_ENST00000519692.1_RNA	NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	219	SRCR 2.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TCCAGTGCTTGTCACAGATCT	0.557000													64	130					5.00936e-31	6.25429e-31	1	1	0
SYT7	9066	broad.mit.edu	37	11	61295549	61295549	+	Missense_Mutation	SNP	C	C	T	rs382505		TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:61295549C>T	ENST00000263846.4	-	5	787	c.460G>A	c.(460-462)Gtg>Atg	p.V154M	SYT7_ENST00000535826.1_Missense_Mutation_p.V273M|SYT7_ENST00000542836.1_Missense_Mutation_p.V198M|SYT7_ENST00000540677.1_Missense_Mutation_p.V229M|SYT7_ENST00000539008.1_Missense_Mutation_p.V437M|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542670.1_Missense_Mutation_p.V362M	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	154	C2 1.			V -> L (in Ref. 1; AAB92667).		cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						ATGATCTTCACGGTGAGCGTG	0.612000													27	74					0	0	1	0	0
FSCN1	6624	broad.mit.edu	37	7	5643496	5643496	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr7:5643496G>C	ENST00000382361.3	+	4	1228	c.1114G>C	c.(1114-1116)Gac>Cac	p.D372H	FSCN1_ENST00000340250.6_Missense_Mutation_p.D351H	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	372					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		TGGGACAGGGGACTCAGAGCT	0.642000													34	38					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111064170	111064170	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:111064170C>T	ENST00000551590.1	+	3	501	c.345C>T	c.(343-345)ggC>ggT	p.G115G	TCTN1_ENST00000397659.4_Silent_p.G115G|TCTN1_ENST00000397655.3_Silent_p.G115G|TCTN1_ENST00000471804.2_Silent_p.G115G|TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000550703.2_Silent_p.G115G|TCTN1_ENST00000377654.3_5'UTR			Q2MV58	TECT1_HUMAN	tectonic family member 1	115					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ttttCAGGGGCGACAGCCAGT	0.318000													4	5					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83810035	83810035	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr11:83810035C>T	ENST00000398309.2	-	5	835	c.365G>A	c.(364-366)gGa>gAa	p.G122E	DLG2_ENST00000543673.1_Missense_Mutation_p.G227E|DLG2_ENST00000537455.1_5'UTR|DLG2_ENST00000532653.1_Missense_Mutation_p.G122E|DLG2_ENST00000524982.1_Missense_Mutation_p.G122E|DLG2_ENST00000376104.2_Missense_Mutation_p.G227E|DLG2_ENST00000531015.1_Missense_Mutation_p.G89E|DLG2_ENST00000418306.2_Missense_Mutation_p.G71E|DLG2_ENST00000280241.8_Missense_Mutation_p.G161E|DLG2_ENST00000330014.6_Missense_Mutation_p.G61E|DLG2_ENST00000398301.2_Missense_Mutation_p.G161E|DLG2_ENST00000376106.3_5'UTR	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	122	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				AGGGTCATCTCCAATGTGGGG	0.423000													4	73					0	0	1	0	0
HADHA	3030	broad.mit.edu	37	2	26416519	26416519	+	Silent	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:26416519G>T	ENST00000380649.3	-	17	1941	c.1812C>A	c.(1810-1812)ggC>ggA	p.G604G		NM_000182.4	NP_000173.2	P40939	ECHA_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	604					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(4)|skin(1)	30	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	CAAAGACTTTGCCCAGATCTT	0.527000													9	359					1.76689e-08	1.96218e-08	1	1	0
NDUFV3	4731	broad.mit.edu	37	21	44329071	44329071	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr21:44329071C>T	ENST00000354250.2	+	4	1431	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L	NDUFV3_ENST00000340344.3_Silent_p.L89L|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	89					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	ACCTCAACCTCGAACTCTCAA	0.552000													5	153					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49901254	49901254	+	Silent	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:49901254C>T	ENST00000447857.3	+	7	688	c.483C>T	c.(481-483)gaC>gaT	p.D161D		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	161						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						CCACAGCTGACCTGCTGAGCA	0.612000													16	10					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70961531	70961531	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:70961531C>T	ENST00000322954.6	-	16	1677	c.1492G>A	c.(1492-1494)Gca>Aca	p.A498T	UACA_ENST00000560441.1_Missense_Mutation_p.A483T|UACA_ENST00000379983.2_Missense_Mutation_p.A485T|UACA_ENST00000539319.1_Missense_Mutation_p.A389T	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	498						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TCTTTTAATGCATCTTCTAAT	0.378000													139	126					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98273920	98273920	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:98273920G>A	ENST00000289228.5	-	9	1194	c.978C>T	c.(976-978)atC>atT	p.I326I		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	326						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						CCTTGATTTTGATATCCTTTG	0.582000													101	147					0	0	1	0	0
CCDC142	84865	broad.mit.edu	37	2	74709145	74709145	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:74709145G>T	ENST00000393965.3	-	1	1216	c.820C>A	c.(820-822)Ctg>Atg	p.L274M	CCDC142_ENST00000471713.1_5'UTR|CCDC142_ENST00000290418.4_Missense_Mutation_p.L274M	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	274										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CCTGGTAGCAGATCCCCCTCC	0.697000													15	45					2.23348e-06	2.40441e-06	1	1	0
SRRM4	84530	broad.mit.edu	37	12	119583391	119583391	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr12:119583391A>G	ENST00000267260.4	+	9	1365	c.977A>G	c.(976-978)aAc>aGc	p.N326S		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	326	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						AACAGTGGCAACACCTCTGAT	0.627000													13	10					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154600401	154600401	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr1:154600401A>C	ENST00000292205.5	-	1	73	c.74T>G	c.(73-75)gTg>gGg	p.V25G	ADAR_ENST00000471068.1_Intron|ADAR_ENST00000368471.3_5'UTR	NM_001025107.2|NM_001193495.1	NP_001020278.1|NP_001180424.1	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	0					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CCCTCCCCCCACCCTCCCCCA	0.642000													8	48					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106876282	106876282	+	Silent	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr9:106876282G>A	ENST00000286398.7	+	12	1740	c.1452G>A	c.(1450-1452)caG>caA	p.Q484Q	SMC2_ENST00000303219.8_Silent_p.Q484Q|SMC2_ENST00000374787.3_Silent_p.Q484Q|SMC2_ENST00000374793.3_Silent_p.Q484Q	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	484					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						AGCGCAGGCAGCTGTCTCGTG	0.348000													10	163					0	0	1	0	0
EIF2B5	8893	broad.mit.edu	37	3	183860047	183860047	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr3:183860047C>T	ENST00000273783.3	+	9	1447	c.1325C>T	c.(1324-1326)aCg>aTg	p.T442M	EIF2B5_ENST00000444495.1_Missense_Mutation_p.T442M	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	442					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding	p.T442M(1)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCAAATATCACGCTGCCTGAG	0.483000													5	312					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11346520	11346520	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:11346520C>G	ENST00000304623.8	-	9	1781	c.1592G>C	c.(1591-1593)aGg>aCg	p.R531T	CTNND2_ENST00000511377.1_Missense_Mutation_p.R440T|CTNND2_ENST00000503622.1_Missense_Mutation_p.R194T|CTNND2_ENST00000458100.2_Missense_Mutation_p.R98T|CTNND2_ENST00000359640.2_Missense_Mutation_p.R531T|CTNND2_ENST00000495388.2_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	531					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GGACGGGGACCTGGCCAAGGT	0.498000													34	89					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66039262	66039262	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:66039262G>A	ENST00000537025.2	+	7	1333	c.713G>A	c.(712-714)cGc>cAc	p.R238H	KPNA2_ENST00000330459.3_Missense_Mutation_p.R238H			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	238	NLS binding site (major) (By similarity).				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			AATCTTTGCCGCAACAAGAAT	0.453000													6	576					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16742741	16742741	+	Missense_Mutation	SNP	G	G	A	rs140297141		TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr2:16742741G>A	ENST00000381323.3	-	7	716	c.496C>T	c.(496-498)Cgc>Tgc	p.R166C	FAM49A_ENST00000406434.1_Missense_Mutation_p.R166C|FAM49A_ENST00000355549.2_Missense_Mutation_p.R166C	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	166						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTGTTGATGCGGTTGCGACTG	0.483000													5	79					0	0	1	0	0
CCL4L1	9560	broad.mit.edu	37	17	34539766	34539766	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:34539766A>T	ENST00000378350.4	+	3	440	c.222A>T	c.(220-222)agA>agT	p.R74S	CCL4L1_ENST00000591637.1_Missense_Mutation_p.S85C|CCL4L1_ENST00000389068.5_Intron|CCL4L1_ENST00000591167.1_Splice_Site_p.V64_splice|CCL4L1_ENST00000444414.1_Intron|CCL4L1_ENST00000589336.1_3'UTR|CCL4L1_ENST00000378352.4_Intron|CCL4L1_ENST00000588929.1_Intron|CCL4L1_ENST00000586598.1_3'UTR|CCL4L1_ENST00000400702.4_Missense_Mutation_p.S50C|CCL4L1_ENST00000589079.1_Missense_Mutation_p.R81S|CCL4L1_ENST00000358756.5_Intron					chemokine (C-C motif) ligand 4-like 1														Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		catccaccagagctgccccac	0.557000													5	9					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26885845	26885846	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr5:26885845_26885846delCG	ENST00000231021.4	-	11	1931_1932	c.1759_1760delCG	c.(1759-1761)tfs	p.R587fs		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	587	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GGCACACACACGGATAGTGAGT	0.480													17	32	---	---	---	---					
HDAC2	3066	broad.mit.edu	37	6	114292109	114292110	+	In_Frame_Ins	INS	-	-	CTG			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr6:114292109_114292110insCTG	ENST00000398283.2	-	1	249_250	c.245_246insCAG	c.(244-246)aag>aCAGag	p.82_82K>TE	HDAC2_ENST00000519065.1_5'UTR|RP3-399L15.3_ENST00000520554.1_RNA|RP3-399L15.3_ENST00000449620.2_RNA|HDAC2_ENST00000368632.2_5'UTR|RP3-399L15.3_ENST00000436876.2_RNA|RP3-399L15.3_ENST00000519104.1_RNA	NM_001527.3	NP_001518.3	Q92769	HDAC2_HUMAN	histone deacetylase 2	0	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GGCTCCTCCTCctgctgctgct	0.688													4	6	---	---	---	---					
XPO4	64328	broad.mit.edu	37	13	21396296	21396297	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr13:21396296_21396297insAA	ENST00000400602.2	-	8	1007_1008	c.972_973insTT	c.(970-975)atagggfs	p.G325fs	XPO4_ENST00000255305.6_Frame_Shift_Ins_p.G325fs	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	325					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AGTAATCCCTCAATGAAGTGTG	0.416													11	87	---	---	---	---					
FAM63B	54629	broad.mit.edu	37	15	59144132	59144134	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr15:59144132_59144134delGCT	ENST00000559228.1	+	8	1787_1789	c.1705_1707delGCT	c.(1705-1707)del	p.A574del	FAM63B_ENST00000450403.2_In_Frame_Del_p.A574del			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	574	Gln-rich.									central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						ACAAGCAGCAGCTGCTGCTGCTG	0.468													8	128	---	---	---	---					
TMEM132E	124842	broad.mit.edu	37	17	32957035	32957035	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr17:32957035delG	ENST00000321639.5	+	6	1405	c.1077delG	c.(1075-1077)gafs	p.E359fs		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	359						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		AGGACACAGAGATCATCAACA	0.622													17	34	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9049102	9049103	+	Frame_Shift_Ins	INS	-	-	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:9049102_9049103insA	ENST00000397910.4	-	5	32731_32732	c.32528_32529insT	c.(32527-32529)tcafs	p.S10843fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10845	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTTACTATGGAAAAAAATGGA	0.490													72	196	---	---	---	---					
HNRNPL	3191	broad.mit.edu	37	19	39330750	39330751	+	Frame_Shift_Ins	INS	-	-	A			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr19:39330750_39330751insA	ENST00000221419.5	-	8	1584_1585	c.1218_1219insT	c.(1216-1221)tagcaafs	p.*Q406fs	AC104534.3_ENST00000594769.1_Frame_Shift_Ins_p.S23fs|HNRNPL_ENST00000600873.1_Frame_Shift_Ins_p.*Q273fs	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	406	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TCCACATTGCCATATAAGCAGA	0.569													76	104	---	---	---	---					
CCDC157	550631	broad.mit.edu	37	22	30768235	30768237	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:30768235_30768237delAGG	ENST00000405659.1	+	7	2004_2006	c.1295_1297delAGG	c.(1294-1299)aag>a	p.KE432del	CCDC157_ENST00000338306.3_In_Frame_Del_p.KE432del			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	432										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						GAGCTGGATAAGGAGAAGGCCCG	0.665													7	5	---	---	---	---					
RABL2B	11158	broad.mit.edu	37	22	51207956	51207957	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A8Z7-01A-11D-A391-08	TCGA-QK-A8Z7-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	30edd8e9-a4a0-44b1-9d9d-9729d1d43180	4f78ee17-151d-4359-b464-8cda333d247c	g.chr22:51207956_51207957insT	ENST00000395595.3	-	8	900_901	c.433_434insA	c.(433-435)cttfs	p.L145fs	RABL2B_ENST00000395598.3_Frame_Shift_Ins_p.L144fs|RABL2B_ENST00000354869.3_Frame_Shift_Ins_p.L145fs|RABL2B_ENST00000395593.3_Frame_Shift_Ins_p.L144fs|RABL2B_ENST00000435118.1_Frame_Shift_Ins_p.L144fs|RABL2B_ENST00000465063.1_5'UTR|RABL2B_ENST00000395591.1_Frame_Shift_Ins_p.L81fs	NM_001130921.1	NP_001124393.1	Q9UNT1	RBL2B_HUMAN	RAB, member of RAS oncogene family-like 2B	144					small GTPase mediated signal transduction		GTP binding|GTPase activity			lung(1)	1		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.0539)|LUAD - Lung adenocarcinoma(64;0.247)		AAAATTGAAGCTTTTTTGGGTC	0.515													10	112	---	---	---	---					
