Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADCY2	108	broad.mit.edu	37	5	7706894	7706894	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr5:7706894C>T	ENST00000338316.4	+	8	1236	c.1147C>T	c.(1147-1149)Cgc>Tgc	p.R383C	ADCY2_ENST00000537121.1_Missense_Mutation_p.R203C	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	383					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TATCAACATGCGCGTGGGCGT	0.473000													57	224					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96021600	96021600	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr9:96021600G>A	ENST00000297954.4	+	11	2770	c.2770G>A	c.(2770-2772)Gtc>Atc	p.V924I	WNK2_ENST00000395477.2_Missense_Mutation_p.V924I|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.V536I|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.V536I			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	924					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCCTACTGACGTCCCTCCTTC	0.667000													25	28					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950713	198950713	+	Silent	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr2:198950713G>A	ENST00000428675.1	+	2	2870	c.2472G>A	c.(2470-2472)cgG>cgA	p.R824R	PLCL1_ENST00000437704.2_Silent_p.R726R	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	824					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CTGGATATCGGCATGTTCCCC	0.448000													4	86					0	0	1	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67560661	67560661	+	RNA	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr11:67560661G>A	ENST00000528089.1	-	0	1089																											TCGTATGTGAGTCCTACAGTG	0.463000													4	109					0	0	1	0	0
ZNF781	163115	broad.mit.edu	37	19	38160892	38160892	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr19:38160892C>T	ENST00000358582.4	-	4	906	c.158G>A	c.(157-159)cGa>cAa	p.R53Q	ZNF781_ENST00000590008.1_Missense_Mutation_p.R53Q|ZFP30_ENST00000586732.1_Intron	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R53Q(1)		NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						AGTGTGAATTCGATTATGTTG	0.383000													72	179					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202097353	202097353	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:202097353C>T	ENST00000367282.4	+	2	1221	c.1115C>T	c.(1114-1116)aCc>aTc	p.T372I		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1	372						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						GCCTTCTGCACCCTCCCAGAG	0.632000													27	59					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50272780	50272780	+	Splice_Site	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:50272780C>T	ENST00000332853.3	-	5	659	c.634_splice	c.e5-1	p.V212_splice		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	212						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						AATAATGTCTCACTGTGAAAG	0.353000													22	77					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124856569	124856569	+	Splice_Site	SNP	G	G	A	rs147831485	by1000genomes	TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:124856569G>A	ENST00000356219.3	-	21	2961	c.2807_splice	c.e21+1	p.R936_splice	NCOR2_ENST00000397355.1_Splice_Site_p.R919_splice|NCOR2_ENST00000429285.2_Splice_Site_p.R918_splice|NCOR2_ENST00000404121.2_Splice_Site_p.R489_splice|NCOR2_ENST00000405201.1_Splice_Site_p.R936_splice|NCOR2_ENST00000404621.1_Splice_Site_p.R918_splice	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	936					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCCACTCACCGGTTCTTGTCG	0.647000													12	26					0	0	1	0	0
CDKL1	8814	broad.mit.edu	37	14	50808858	50808858	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr14:50808858C>T	ENST00000216378.2	-	5	1093	c.449G>A	c.(448-450)cGg>cAg	p.R150Q	CDKL1_ENST00000395834.1_Missense_Mutation_p.R150Q|CDKL1_ENST00000356146.1_5'UTR			Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1 (CDC2-related kinase)	149	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|stomach(1)	12	all_epithelial(31;0.000746)|Breast(41;0.0102)					ACTCAAAAGCCGAGCAAATCC	0.328000													4	104					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156499965	156499965	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:156499965G>A	ENST00000361170.2	-	34	4346	c.4336C>T	c.(4336-4338)Cga>Tga	p.R1446*		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1446					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCTTCAAGTCGGCGTAGGTTC	0.652000													7	5					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80651657	80651657	+	Silent	SNP	A	A	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:80651657A>T	ENST00000458043.2	+	17	1743	c.1737A>T	c.(1735-1737)acA>acT	p.T579T	OTOGL_ENST00000547103.1_Silent_p.T579T	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TAAAAACCACATTTGGTTTAA	0.343000													7	25					0	0	1	0	0
MBL1P	8512	broad.mit.edu	37	10	81680769	81680769	+	RNA	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:81680769G>A	ENST00000480805.1	+	0	836					NR_002724.2																						GAAACACAGGGACTTCTGGAA	0.592000													4	23					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125592402	125592402	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr4:125592402C>T	ENST00000504087.1	-	4	3067	c.2030G>A	c.(2029-2031)gGt>gAt	p.G677D	ANKRD50_ENST00000515641.1_Missense_Mutation_p.G498D	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	677										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						AGCAGTTCTACCTTCATTATC	0.463000													51	81					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	79					0	0	1	0	0
CYTH3	9265	broad.mit.edu	37	7	6204942	6204942	+	Silent	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr7:6204942C>T	ENST00000350796.3	-	12	1225	c.1089G>A	c.(1087-1089)ccG>ccA	p.P363P	CYTH3_ENST00000396741.2_Silent_p.P278P	NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	364	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						CCTCCGGGCTCGGGGCTGAGA	0.647000													31	34					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39626997	39626997	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:39626997G>A	ENST00000265708.4	-	12	1229	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	ADAM2_ENST00000379853.2_Missense_Mutation_p.R250C|ADAM2_ENST00000521880.1_Missense_Mutation_p.R376C|ADAM2_ENST00000347580.4_Missense_Mutation_p.R357C	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	376					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GGATCTAAGCGAGGCTGATTG	0.433000													19	135					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70505431	70505431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:70505431G>A	ENST00000310961.5	+	22	4243	c.3825G>A	c.(3823-3825)tgG>tgA	p.W1275*	LRRC7_ENST00000415775.2_Nonsense_Mutation_p.W554*|LRRC7_ENST00000035383.5_Nonsense_Mutation_p.W1270*			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1270						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CTGCAGACTGGAGACAACAGC	0.448000													46	97					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36372605	36372605	+	Silent	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:36372605C>T	ENST00000373204.4	+	12	1680	c.1467C>T	c.(1465-1467)ttC>ttT	p.F489F	AGO1_ENST00000373206.1_Silent_p.F414F	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		AACCTTGTTTCTGCAAATATG	0.537000													45	71					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28217203	28217203	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:28217203G>T	ENST00000344423.5	-	3	510	c.379C>A	c.(379-381)Ctg>Atg	p.L127M	ZNF395_ENST00000523202.1_Missense_Mutation_p.L127M|ZNF395_ENST00000523095.1_Missense_Mutation_p.L127M	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	127					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGCCCTGCAGCTCTGCCAGC	0.662000													15	122					1.3612e-06	1.40245e-06	1	1	0
MINOS1	440574	broad.mit.edu	37	1	19923551	19923551	+	Silent	SNP	G	G	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:19923551G>T	ENST00000322753.6	+	1	68	c.12G>T	c.(10-12)tcG>tcT	p.S4S	MINOS1-NBL1_ENST00000602662.1_5'UTR|MINOS1_ENST00000486890.1_3'UTR	NM_001032363.3|NM_001204082.1|NM_001204083.1	NP_001027535.1|NP_001191011.1|NP_001191012.1	Q5TGZ0	CA151_HUMAN	mitochondrial inner membrane organizing system 1	4						integral to membrane|mitochondrion											TGTCTGAGTCGGAGCTCGGCA	0.667000													25	38					2.44723e-14	2.68406e-14	1	1	0
KCNH3	23416	broad.mit.edu	37	12	49948282	49948282	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:49948282G>A	ENST00000257981.6	+	11	2341	c.2081G>A	c.(2080-2082)cGt>cAt	p.R694H		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	694					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						CGCTTCAGTCGTGGCCTCCGA	0.652000													30	66					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62019186	62019186	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:62019186C>T	ENST00000435607.1	-	24	4532	c.4456G>A	c.(4456-4458)Ggc>Agc	p.G1486S	SCN4A_ENST00000578147.1_Missense_Mutation_p.G1486S	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1486					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AGGAGGAGGCCGATGTTGAAG	0.582000													15	44					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21333768	21333768	+	Silent	SNP	T	T	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr18:21333768T>C	ENST00000313654.9	+	6	1180	c.939T>C	c.(937-939)ccT>ccC	p.P313P	LAMA3_ENST00000399516.3_Silent_p.P313P	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	313	Domain V.|Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAAACAATCCTGAAAAACTGT	0.368000													4	50					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	39					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129172386	129172386	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:129172386G>A	ENST00000280333.6	+	35	3629	c.3520G>A	c.(3520-3522)Gtt>Att	p.V1174I		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1174	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TGTAAAACTCGTTGTGCGCTT	0.423000													13	26					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78341825	78341825	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:78341825G>A	ENST00000582970.1	+	44	12180	c.12037G>A	c.(12037-12039)Gac>Aac	p.D4013N	CTD-2047H16.4_ENST00000575034.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.D4062N|RNF213_ENST00000336301.6_Missense_Mutation_p.D2086N	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCTGCCCTGCGACCACGTGCA	0.562000													38	90					0	0	1	0	0
RNF5	6048	broad.mit.edu	37	6	32147865	32147865	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr6:32147865C>T	ENST00000427134.2	+	5	422	c.407C>T	c.(406-408)aCc>aTc	p.T136I	RNF5_ENST00000375094.3_Missense_Mutation_p.T136I			Q99942	RNF5_HUMAN	ring finger protein 5, E3 ubiquitin protein ligase	136					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.T136I(3)		endometrium(1)|lung(7)|urinary_tract(2)	10						TTTTTCACCACCGTCTTCAAT	0.557000													6	122					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8741071	8741071	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:8741071G>A	ENST00000378641.3	+	25	3149	c.2674G>A	c.(2674-2676)Gcc>Acc	p.A892T	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.A892T|PLCB1_ENST00000338037.6_Missense_Mutation_p.A892T	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	892					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AAAGGCACCTGCCAAAACAGA	0.358000													5	235					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64505656	64505656	+	Silent	SNP	T	T	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:64505656T>C	ENST00000355086.3	+	17	2558	c.2034T>C	c.(2032-2034)caT>caC	p.H678H	RP11-196H14.4_ENST00000535806.1_RNA|SRGAP1_ENST00000357825.3_Silent_p.H655H|SRGAP1_ENST00000543397.1_Silent_p.H615H	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	678	Rho-GAP.				axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GCCAGGCACATGTGAATGAAA	0.443000													8	139					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376809.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	40					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37034286	37034286	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr3:37034286C>T	ENST00000322716.5	-	1	509	c.283G>A	c.(283-285)Gag>Aag	p.E95K		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	95						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						GCAGCTCTCTCTTCAGGAGTG	0.652000													40	74					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7214537	7214537	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:7214537G>A	ENST00000361972.4	-	18	2161	c.2071C>T	c.(2071-2073)Cgg>Tgg	p.R691W	SFMBT2_ENST00000397167.1_Missense_Mutation_p.R691W	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	691					regulation of transcription, DNA-dependent	nucleus		p.R691W(2)		NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						CGCTTCCTCCGCCTGGCGGGT	0.587000													9	22					0	0	1	0	0
BTN2A1	11120	broad.mit.edu	37	6	26458872	26458872	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr6:26458872C>T	ENST00000429381.1	+	2	220	c.8C>T	c.(7-9)tCa>tTa	p.S3L	BTN2A1_ENST00000469185.1_Missense_Mutation_p.S3L|BTN2A1_ENST00000312541.5_Missense_Mutation_p.S3L|BTN2A1_ENST00000541522.1_Intron			Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	3					lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						CTCATGGAATCAGCTGCTGCC	0.622000													4	74					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41019010	41019010	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr5:41019010G>A	ENST00000399564.4	-	25	3002	c.2552C>T	c.(2551-2553)aCa>aTa	p.T851I	MROH2B_ENST00000506092.2_Missense_Mutation_p.T406I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GTCCTTGTCTGTCTGGCCTTC	0.507000													33	25					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59482066	59482066	+	Silent	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:59482066C>T	ENST00000240328.3	+	5	1268	c.987C>T	c.(985-987)ccC>ccT	p.P329P	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	329					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						ACCCTCCCCCCGCGCGGGAAC	0.726000													6	6					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43531784	43531784	+	Missense_Mutation	SNP	A	A	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr21:43531784A>C	ENST00000400427.1	+	11	2632	c.2236A>C	c.(2236-2238)Acc>Ccc	p.T746P	UMODL1_ENST00000400424.1_Missense_Mutation_p.T618P|UMODL1_ENST00000408989.2_Missense_Mutation_p.T818P|UMODL1_ENST00000408910.2_Missense_Mutation_p.T690P	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	734	Fibronectin type-III 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CCTGCCATTGACCTCCACCCT	0.582000													6	39					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47251276	47251276	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:47251276G>A	ENST00000396220.1	-	33	4227	c.4205C>T	c.(4204-4206)aCg>aTg	p.T1402M	PREX1_ENST00000371941.3_Missense_Mutation_p.T1402M			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1402					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCTGACAGCGTCACCCAGAT	0.562000													40	66					0	0	1	0	0
FOXF1	2294	broad.mit.edu	37	16	86544260	86544260	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr16:86544260G>A	ENST00000262426.4	+	1	128	c.85G>A	c.(85-87)Gcg>Acg	p.A29T		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	29					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						CATGGACCCCGCGTCGTCCGG	0.736000													11	13					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36775191	36775191	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:36775191G>A	ENST00000361475.2	-	6	960	c.787C>T	c.(787-789)Cgc>Tgc	p.R263C	TGM2_ENST00000536724.1_Missense_Mutation_p.R203C|TGM2_ENST00000536701.1_Missense_Mutation_p.R182C	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	263					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TTCTTCCAGCGCCGCAGGATG	0.652000													12	67					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140291481	140291481	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr4:140291481C>T	ENST00000296543.5	+	15	2193	c.1870C>T	c.(1870-1872)Cag>Tag	p.Q624*	NAA15_ENST00000398947.1_Nonsense_Mutation_p.Q624*	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	624					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						gcagagaaatcagaaaaagaa	0.358000													21	32					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64978326	64978326	+	Missense_Mutation	SNP	A	A	G			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr11:64978326A>G	ENST00000527323.1	+	20	2341	c.2101A>G	c.(2101-2103)Acc>Gcc	p.T701A	CAPN1_ENST00000533129.1_Missense_Mutation_p.T701A|CAPN1_ENST00000533820.1_Missense_Mutation_p.T701A|CAPN1_ENST00000524773.1_Missense_Mutation_p.T701A|CAPN1_ENST00000279247.6_Missense_Mutation_p.T701A			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	701	Domain IV.|EF-hand 4.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TGGAGTTGTGACCTTTGACTT	0.483000													24	51					0	0	1	0	0
RGS20	8601	broad.mit.edu	37	8	54859258	54859258	+	Silent	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:54859258C>T	ENST00000297313.3	+	4	785	c.693C>T	c.(691-693)ccC>ccT	p.P231P	RGS20_ENST00000517405.1_3'UTR|RGS20_ENST00000522225.1_5'UTR|RGS20_ENST00000276500.4_Silent_p.P84P|RGS20_ENST00000344277.6_Silent_p.P116P	NM_170587.2	NP_733466.1	O76081	RGS20_HUMAN	regulator of G-protein signaling 20	231					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			breast(2)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			ATCAGAGGCCCACAATAGCTT	0.403000													29	163					0	0	1	0	0
TRGV5	6978	broad.mit.edu	37	7	38388960	38388960	+	RNA	SNP	T	T	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr7:38388960T>C	ENST00000390344.2	-	0	547																											ACTGTGCCTGTCCCAGGTGGC	0.478000													4	74					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35635822	35635822	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:35635822C>T	ENST00000373664.3	-	20	2929	c.2863G>A	c.(2863-2865)Gac>Aac	p.D955N	RBL1_ENST00000344359.3_Missense_Mutation_p.D955N	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	955					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				ACCATATGGTCCTGATTCGCC	0.303000													33	142					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													4	81					0.00024832	0.000250779	1	1	0
SLC1A7	6512	broad.mit.edu	37	1	53600102	53600102	+	Splice_Site	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:53600102C>T	ENST00000371494.4	-	2	263		c.e2-1		SLC1A7_ENST00000371491.4_Splice_Site	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7							integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	AACTAATTTCCTGAAAACACA	0.502000													8	23					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140441448	140441448	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr4:140441448G>A	ENST00000274031.3	-	6	1381	c.745C>T	c.(745-747)Cga>Tga	p.R249*	SETD7_ENST00000506866.2_Nonsense_Mutation_p.R249*	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	249	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					TGTGTAATTCGAACTCCATTA	0.398000													4	92					0	0	1	0	0
DUSP14	11072	broad.mit.edu	37	17	35872745	35872745	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:35872745C>T	ENST00000487847.1	+	2	1349	c.371C>T	c.(370-372)gCg>gTg	p.A124V	DUSP14_ENST00000394386.1_Missense_Mutation_p.A124V|DUSP14_ENST00000394389.4_Missense_Mutation_p.A124V			O95147	DUS14_HUMAN	dual specificity phosphatase 14	124	Tyrosine-protein phosphatase.						MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|urinary_tract(1)	9		Breast(25;0.00637)|Ovarian(249;0.15)				CTGTGTATCGCGTACCTGATG	0.602000													22	27					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776794	5776794	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr11:5776794G>T	ENST00000317254.3	+	1	872	c.824G>T	c.(823-825)tGc>tTc	p.C275F	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CCCCCTTCTTGCCACATCATT	0.458000													31	93					2.70662e-09	2.84614e-09	1	1	0
PDLIM2	64236	broad.mit.edu	37	8	22449070	22449070	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:22449070C>T	ENST00000265810.4	+	8	885	c.770C>T	c.(769-771)aCg>aTg	p.T257M	PDLIM2_ENST00000409417.1_Missense_Mutation_p.T257M|AC037459.4_ENST00000430850.2_Missense_Mutation_p.T51M|PDLIM2_ENST00000308354.7_Missense_Mutation_p.T507M|PDLIM2_ENST00000409141.1_Intron|PDLIM2_ENST00000397760.4_Missense_Mutation_p.T257M|PDLIM2_ENST00000397761.2_Missense_Mutation_p.T257M|PDLIM2_ENST00000448520.1_3'UTR|PDLIM2_ENST00000339162.7_Intron	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	257						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CCAGGTGGCACGCCAGCCTTC	0.632000													9	62					0	0	1	0	0
RRP1	8568	broad.mit.edu	37	21	45213265	45213265	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr21:45213265C>T	ENST00000497547.1	+	4	457	c.340C>T	c.(340-342)Cgc>Tgc	p.R114C		NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	114					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		TGACAGGCTGCGCCTGGATAA	0.622000													5	175					0	0	1	0	0
OTC	5009	broad.mit.edu	37	X	38240682	38240682	+	Splice_Site	SNP	G	G	A	rs66656800		TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chrX:38240682G>A	ENST00000039007.4	+	4	538	c.386_splice	c.e4+1	p.R129_splice	TM4SF2_ENST00000465127.1_Intron|OTC_ENST00000488812.1_3'UTR	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	129			R -> H (in OTCD; 2.1% of wild-type activity; early onset).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	GACACGGCCCGGTTTGTAAAT	0.348000													27	26					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413498	178413498	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr5:178413498G>T	ENST00000231188.5	-	8	1935	c.1757C>A	c.(1756-1758)gCa>gAa	p.A586E	GRM6_ENST00000517717.1_Missense_Mutation_p.A586E|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	586					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CGGCGGGGCTGCCCAGGGGGA	0.701000													14	13					0.000151284	0.00015431	1	1	0
DNAJC14	85406	broad.mit.edu	37	12	56221340	56221340	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:56221340C>A	ENST00000357606.3	-	3	1392	c.1103G>T	c.(1102-1104)tGg>tTg	p.W368L	DNAJC14_ENST00000317269.3_Missense_Mutation_p.W368L|DNAJC14_ENST00000317287.5_Missense_Mutation_p.W368L			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	368					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						AGAATCCAGCCAAGAGAAGAG	0.562000													28	107					4.4194e-11	4.74504e-11	1	1	0
ABCA6	23460	broad.mit.edu	37	17	67132233	67132233	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr17:67132233C>A	ENST00000590645.1	-	4	648	c.460G>T	c.(460-462)Ggt>Tgt	p.G154C	ABCA6_ENST00000284425.2_Splice_Site_p.A154_splice			Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	0					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					GGAAAGTCACCTGAGAAATCT	0.328000													20	42					1.56452e-12	1.69767e-12	1	1	0
KCNB2	9312	broad.mit.edu	37	8	73480508	73480508	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:73480508G>T	ENST00000523207.1	+	2	1127	c.539G>T	c.(538-540)tGg>tTg	p.W180L		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	180					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AAGAAACTGTGGGACTTGCTG	0.463000													37	232					9.8876e-21	1.09623e-20	1	1	0
PCDH15	65217	broad.mit.edu	37	10	55617002	55617002	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr10:55617002C>G	ENST00000373965.2	-	29	4154	c.3760G>C	c.(3760-3762)Gat>Cat	p.D1254H	PCDH15_ENST00000320301.6_Missense_Mutation_p.D1247H|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Missense_Mutation_p.D1247H|PCDH15_ENST00000395430.1_Missense_Mutation_p.D1247H|PCDH15_ENST00000361849.3_Missense_Mutation_p.D1247H|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395445.1_Missense_Mutation_p.D1254H|PCDH15_ENST00000395433.1_Missense_Mutation_p.D1225H|PCDH15_ENST00000414778.1_Missense_Mutation_p.D1252H|PCDH15_ENST00000437009.1_Missense_Mutation_p.D1176H|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000409834.1_Missense_Mutation_p.D858H|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.D1210H	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1247	Cadherin 11.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTTGCATATCCAGCTGATTG	0.333000										HNSCC(58;0.16)			35	85					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													5	236					0	0	1	0	0
DNAJC14	85406	broad.mit.edu	37	12	56221331	56221331	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:56221331G>C	ENST00000357606.3	-	3	1401	c.1112C>G	c.(1111-1113)tCt>tGt	p.S371C	DNAJC14_ENST00000317269.3_Missense_Mutation_p.S371C|DNAJC14_ENST00000317287.5_Missense_Mutation_p.S371C			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	371					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						CAAGGCTGGAGAATCCAGCCA	0.557000													30	105					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768233	77768233	+	Missense_Mutation	SNP	A	A	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:77768233A>T	ENST00000521891.2	+	10	9524	c.9076A>T	c.(9076-9078)Att>Ttt	p.I3026F	ZFHX4_ENST00000518282.1_Missense_Mutation_p.I3000F|ZFHX4_ENST00000050961.6_Missense_Mutation_p.I2981F|ZFHX4_ENST00000455469.2_Missense_Mutation_p.I2981F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2981						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGAGATCACATTTTCTCCAA	0.522000										HNSCC(33;0.089)			10	111					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573489	38573489	+	Silent	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr19:38573489G>A	ENST00000222345.6	+	3	1793	c.1284G>A	c.(1282-1284)ccG>ccA	p.P428P		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	428					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCAGCTGCCCGCACTTCCGCA	0.647000													6	112					0	0	1	0	0
SDC3	9672	broad.mit.edu	37	1	31346159	31346159	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:31346159G>A	ENST00000336798.7	-	3	2546	c.1054C>T	c.(1054-1056)Cgt>Tgt	p.R352C	SDC3_ENST00000339394.6_Missense_Mutation_p.R410C			O75056	SDC3_HUMAN	syndecan 3	410						integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTTCATACGATAGATGAGC	0.562000													31	44					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33774800	33774800	+	Silent	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr2:33774800C>T	ENST00000403687.3	+	14	2264	c.1524C>T	c.(1522-1524)tgC>tgT	p.C508C	RASGRP3_ENST00000407811.1_Silent_p.C507C|RASGRP3_ENST00000402538.3_Silent_p.C508C	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	508					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					CAACCTTCTGCGAACACTGTG	0.388000													10	28					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90455081	90455081	+	Silent	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr6:90455081G>A	ENST00000369393.3	-	29	4204	c.4089C>T	c.(4087-4089)atC>atT	p.I1363I	MDN1_ENST00000428876.1_Silent_p.I1363I			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1363					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CAGTCCACACGATATGGCCAA	0.433000													35	69					0	0	1	0	0
IL9	3578	broad.mit.edu	37	5	135229825	135229825	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr5:135229825G>C	ENST00000274520.1	-	4	209	c.199C>G	c.(199-201)Cca>Gca	p.P67A		NM_000590.1	NP_000581.1	P15248	IL9_HUMAN	interleukin 9	67					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity			large_intestine(3)|lung(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTGAAGCATGGTCTGGTGCAG	0.373000													4	59					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424579	56424579	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr19:56424579C>T	ENST00000588751.1	-	5	628	c.604G>A	c.(604-606)Gta>Ata	p.V202I	NLRP13_ENST00000342929.3_Missense_Mutation_p.V202I			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	202							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CGGATATATACGTGGTCTTTA	0.498000													8	191					0	0	1	0	0
CD47	961	broad.mit.edu	37	3	107799072	107799072	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr3:107799072C>T	ENST00000355354.7	-	2	282	c.166G>A	c.(166-168)Gta>Ata	p.V56I	CD47_ENST00000361309.5_Missense_Mutation_p.V56I	NM_198793.2	NP_942088.1	Q08722	CD47_HUMAN	CD47 molecule	56	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			TTCCACTTTACGTATACTTCA	0.353000													35	123					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68249661	68249661	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr14:68249661C>T	ENST00000347230.4	-	21	4346	c.4208G>A	c.(4207-4209)gGc>gAc	p.G1403D	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.G1403D	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1403					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGAATGTAGGCCCAGGAGAAC	0.577000													40	85					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2643960	2643960	+	Splice_Site	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr9:2643960G>A	ENST00000382100.2	+	7	1422		c.e7+1		VLDLR_ENST00000382099.2_Splice_Site	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor						cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		AAAGAGTGTCGTAAGTGTACT	0.448000													35	123					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4735810	4735810	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr12:4735810G>A	ENST00000545990.2	-	5	2782	c.2258C>T	c.(2257-2259)gCa>gTa	p.A753V	AKAP3_ENST00000228850.1_Missense_Mutation_p.A753V	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	753					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						CGTGGGTGCTGCACACCCTTC	0.527000													4	138					0	0	1	0	0
PRDX2	7001	broad.mit.edu	37	19	12907963	12907963	+	Missense_Mutation	SNP	T	T	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr19:12907963T>C	ENST00000301522.2	-	6	657	c.529A>G	c.(529-531)Aag>Gag	p.K177E	CTD-2659N19.10_ENST00000585496.1_RNA|PRDX2_ENST00000334482.5_Missense_Mutation_p.E133G	NM_005809.4	NP_005800.3	P32119	PRDX2_HUMAN	peroxiredoxin 2	177					anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity			endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						CTGCCAGGCTTCCAGCCAGCG	0.522000											OREG0025274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	46					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512606	195512606	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr3:195512606G>C	ENST00000463781.3	-	2	6304	c.5845C>G	c.(5845-5847)Cac>Gac	p.H1949D	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H1949D	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	709					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGTGTGACCTGAGGAT	0.597000													3	5					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33356711	33356711	+	Missense_Mutation	SNP	C	C	T	rs139842383		TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:33356711C>T	ENST00000431156.2	-	8	2125	c.1507G>A	c.(1507-1509)Gca>Aca	p.A503T	MAK16_ENST00000360128.6_3'UTR|TTI2_ENST00000519356.1_Intron|TTI2_ENST00000360742.5_Missense_Mutation_p.A503T|TTI2_ENST00000520636.1_Missense_Mutation_p.A472T	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	503							binding										TTGTAGGGTGCGCCTTCAGAA	0.398000													15	112					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774444	40774444	+	Silent	SNP	T	T	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr9:40774444T>C	ENST00000602553.1	-	5	1125	c.831A>G	c.(829-831)acA>acG	p.T277T	ZNF658_ENST00000441795.1_Silent_p.T275T|ZNF658_ENST00000377626.3_Silent_p.T277T			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGTCACAGGATGTCCCATATT	0.363000													5	451					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605775	142605775	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr7:142605775G>A	ENST00000265310.1	-	15	2443	c.2095C>T	c.(2095-2097)Cga>Tga	p.R699*		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	699					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TCCCAGCCTCGGTGACTGCTG	0.562000													22	44					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4229106	4229106	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:4229106C>T	ENST00000379453.4	-	1	615	c.499G>A	c.(499-501)Gcc>Acc	p.A167T		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	167					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	TCGCAGAAGGCGCGGCCAAAG	0.667000													6	33					0	0	1	0	0
KCNAB2	8514	broad.mit.edu	37	1	6156814	6156814	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr1:6156814delT	ENST00000164247.1	+	14	1487	c.923delT	c.(922-924)aafs	p.I308fs	KCNAB2_ENST00000378111.1_Intron|KCNAB2_ENST00000378092.1_Frame_Shift_Del_p.I294fs|KCNAB2_ENST00000378083.3_Frame_Shift_Del_p.I356fs|KCNAB2_ENST00000378097.1_Frame_Shift_Del_p.I308fs|KCNAB2_ENST00000602612.1_Frame_Shift_Del_p.I308fs|KCNAB2_ENST00000378087.3_Intron|KCNAB2_ENST00000352527.1_Frame_Shift_Del_p.I294fs|KCNAB2_ENST00000341524.1_Frame_Shift_Del_p.I308fs|KCNAB2_ENST00000458166.2_Frame_Shift_Del_p.I241fs	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	308						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCTGGCCATAGGTAACGGT	0.682													2	4	---	---	---	---					
IGKV1D-8	28904	broad.mit.edu	37	2	90259860	90259861	+	RNA	INS	-	-	C			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr2:90259860_90259861insC	ENST00000471857.1	+	0	236																											AATTTACTCAGCCAATGTGCTC	0.480													7	208	---	---	---	---					
SPEF2	79925	broad.mit.edu	37	5	35771703	35771710	+	Splice_Site	DEL	GCAACCAG	GCAACCAG	-	rs138022749	by1000genomes	TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr5:35771703_35771710delGCAACCAG	ENST00000440995.2	+	27	3786		c.e27-1		CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Splice_Site			Q9C093	SPEF2_HUMAN	sperm flagellar 2						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGCTGTTACGCAACCAGGTGGCTGCTG	0.375													9	75	---	---	---	---					
MYBL1	4603	broad.mit.edu	37	8	67488453	67488453	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr8:67488453delT	ENST00000522677.3	-	10	1669	c.1259delA	c.(1258-1260)acfs	p.N420fs	MYBL1_ENST00000517885.1_Intron|MYBL1_ENST00000524176.2_Frame_Shift_Del_p.N420fs	NM_001080416.2|NM_001144755.1	NP_001073885.1|NP_001138227.1	P10243	MYBA_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 1	420	Negative regulatory domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|skin(1)	25			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATTACAAGTGTTTTTTTTCCC	0.403													8	443	---	---	---	---					
AC124997.1	0	broad.mit.edu	37	15	25773086	25773088	+	RNA	DEL	GGT	GGT	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr15:25773086_25773088delGGT	ENST00000422117.1	-	0	167																											TGGTATTTGAggtggtggtggtg	0.542													2	4	---	---	---	---					
MTMR10	54893	broad.mit.edu	37	15	31245804	31245804	+	Frame_Shift_Del	DEL	A	A	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr15:31245804delA	ENST00000435680.1	-	11	1194	c.1097delT	c.(1096-1098)tafs	p.L366fs	MTMR10_ENST00000563714.1_Frame_Shift_Del_p.L284fs|MTMR10_ENST00000425768.1_3'UTR|MTMR10_ENST00000314404.8_Frame_Shift_Del_p.L118fs	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	366	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CAGTGAAGATAACCATTTCTC	0.284													2	4	---	---	---	---					
CACNA1H	8912	broad.mit.edu	37	16	1265068	1265070	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr16:1265068_1265070delTTC	ENST00000348261.5	+	28	5274_5276	c.5026_5028delTTC	c.(5026-5028)del	p.F1677del	CACNA1H_ENST00000358590.4_In_Frame_Del_p.F1671del|CACNA1H_ENST00000565831.1_In_Frame_Del_p.F1671del	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1677					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GTTCCGTCGGTTCTTCAAGGACA	0.621													10	18	---	---	---	---					
YTHDF1	54915	broad.mit.edu	37	20	61833650	61833652	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-TN-A7HI-01A-11D-A34J-08	TCGA-TN-A7HI-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4c79dc7-ef60-45fe-b9e6-f662d4be6b65	7ed9723a-fbd5-4fb9-93e8-ce13ba44b6a4	g.chr20:61833650_61833652delCCT	ENST00000370339.3	-	4	1981_1983	c.1640_1642delAGG	c.(1639-1644)gtg>g	p.EV547del	YTHDF1_ENST00000370333.4_In_Frame_Del_p.EV497del|YTHDF1_ENST00000370334.4_Intron	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	547										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						TTGCGCACCACCTCCTCCTCCTC	0.557													8	256	---	---	---	---					
