Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAT1	2195	broad.mit.edu	37	4	187630900	187630900	+	Nonsense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:187630900C>A	ENST00000441802.2	-	2	291	c.82G>T	c.(82-84)Gaa>Taa	p.E28*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	28					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GGAGTCTGTTCAAGTCGTTGG	0.502000										HNSCC(5;0.00058)			7	32					0.0293803	0.0296325	1	1	0
TP53	7157	broad.mit.edu	37	17	7578211	7578211	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:7578211C>A	ENST00000420246.2	-	6	770	c.638G>T	c.(637-639)cGa>cTa	p.R213L	TP53_ENST00000269305.4_Missense_Mutation_p.R213L|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Missense_Mutation_p.R213L|TP53_ENST00000359597.4_Missense_Mutation_p.R213L|TP53_ENST00000455263.2_Missense_Mutation_p.R213L|TP53_ENST00000445888.2_Missense_Mutation_p.R213L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213L(38)|p.R213Q(29)|p.0?(8)|p.R213P(5)|p.?(5)|p.R120L(4)|p.R81L(4)|p.R120Q(2)|p.R81Q(2)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACTATGTCGAAAAGTGTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	44					0.0293803	0.0296325	1	1	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	105					0	0	1	0	0
LRRC71	149499	broad.mit.edu	37	1	156897444	156897444	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:156897444G>A	ENST00000337428.7	+	7	973	c.819G>A	c.(817-819)gcG>gcA	p.A273A	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	273										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						GCTACATCGCGGACGTGAGTG	0.692000											OREG0013892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	29					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718733	142718733	+	Silent	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:142718733G>C	ENST00000381779.4	-	2	417	c.192C>G	c.(190-192)ctC>ctG	p.L64L	SLITRK4_ENST00000356928.1_Silent_p.L64L|SLITRK4_ENST00000338017.4_Silent_p.L64L	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	64						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGGAAATTGAGGTGATAAA	0.368000													24	126					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169336575	169336575	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:169336575G>A	ENST00000511577.1	-	22	3210	c.2963C>T	c.(2962-2964)gCg>gTg	p.A988V	DDX60L_ENST00000505890.1_Missense_Mutation_p.A988V|DDX60L_ENST00000260184.7_Missense_Mutation_p.A988V			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	988							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TGTCGTTAGCGCAGCACAGGG	0.343000													17	38					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1276645	1276645	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:1276645C>T	ENST00000447027.1	+	37	15990	c.15932C>T	c.(15931-15933)cCg>cTg	p.P5311L	MUC5B_ENST00000529681.1_Missense_Mutation_p.P5308L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5308					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTTGTGCCCCCGGGCCCATTC	0.687000													5	11					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3365871	3365871	+	Splice_Site	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:3365871G>T	ENST00000573128.1	-	5	718	c.233_splice	c.e5-1	p.Q79_splice	SPATA22_ENST00000355380.4_Splice_Site_p.Q36_splice|SPATA22_ENST00000541913.1_Splice_Site_p.Q63_splice|SPATA22_ENST00000397168.3_Splice_Site_p.Q79_splice|SPATA22_ENST00000572969.1_Splice_Site_p.Q79_splice|SPATA22_ENST00000268981.5_Splice_Site_p.Q79_splice|SPATA22_ENST00000575375.1_Splice_Site_p.Q79_splice			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	79										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TGTGGTATTTGCCTTTCAAGG	0.353000													26	73					9.57634e-11	1.02293e-10	1	1	0
RASGRP1	10125	broad.mit.edu	37	15	38808409	38808409	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:38808409G>A	ENST00000310803.5	-	6	841	c.664C>T	c.(664-666)Cgg>Tgg	p.R222W	RASGRP1_ENST00000450598.2_Missense_Mutation_p.R222W|RASGRP1_ENST00000559830.1_Missense_Mutation_p.R222W|RASGRP1_ENST00000558164.1_Missense_Mutation_p.R222W|RASGRP1_ENST00000539159.1_Missense_Mutation_p.R174W|RASGRP1_ENST00000561180.1_Missense_Mutation_p.R273W	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	222	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		GATATCCTCCGGAAAGACTTG	0.448000													7	60					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36100388	36100388	+	Missense_Mutation	SNP	G	G	T	rs144037912		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:36100388G>T	ENST00000377966.3	+	11	1712	c.1146G>T	c.(1144-1146)atG>atT	p.M382I		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	382						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TGAATGACATGAAGTTGTGGG	0.388000													24	70					4.47668e-21	4.93906e-21	1	1	0
GEMIN8	54960	broad.mit.edu	37	X	14027046	14027046	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:14027046G>A	ENST00000380523.4	-	5	1033	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	GEMIN8_ENST00000398355.3_Missense_Mutation_p.P239S	NM_017856.2	NP_060326.1	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	239					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	9						AACTTCAGGGGGATGACCGGC	0.557000													13	119					0	0	1	0	0
CALCA	796	broad.mit.edu	37	11	14991582	14991582	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:14991582G>A	ENST00000361010.3	-	3	200	c.126C>T	c.(124-126)ctC>ctT	p.L42L	CALCA_ENST00000359642.3_Silent_p.L42L|CALCA_ENST00000396372.2_Silent_p.L42L|CALCA_ENST00000331587.4_Silent_p.L42L|CALCA_ENST00000486207.1_Silent_p.L42L|CALCB_ENST00000523376.1_Intron	NM_001033953.2	NP_001029125.1	P06881	CALCA_HUMAN	calcitonin-related polypeptide alpha	42					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	8					Phentolamine(DB00692)	CGTCCTCACTGAGCGTGGCCG	0.637000											OREG0020791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	34					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99006124	99006124	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:99006124G>C	ENST00000393504.1	+	6	870	c.453G>C	c.(451-453)aaG>aaC	p.K151N	CNGA3_ENST00000436404.2_Missense_Mutation_p.K133N|CNGA3_ENST00000409937.1_Missense_Mutation_p.K155N|CNGA3_ENST00000272602.2_Missense_Mutation_p.K151N	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	151					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TTTCCAGGAAGAAGACGAAAA	0.527000													24	242					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215777532	215777532	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:215777532G>A	ENST00000259154.4	+	13	1491	c.1197G>A	c.(1195-1197)gtG>gtA	p.V399V		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	399						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CAGTACGAGTGATTGTACAAC	0.458000													17	79					0	0	1	0	0
AGTR1	185	broad.mit.edu	37	3	148458871	148458871	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:148458871G>A	ENST00000542281.1	+	4	495	c.49G>A	c.(49-51)Gat>Aat	p.D17N	AGTR1_ENST00000404754.2_Missense_Mutation_p.D17N|AGTR1_ENST00000461609.1_Missense_Mutation_p.D17N|AGTR1_ENST00000349243.3_Missense_Mutation_p.D17N|AGTR1_ENST00000418473.2_Missense_Mutation_p.D17N|AGTR1_ENST00000475347.1_Missense_Mutation_p.D17N|AGTR1_ENST00000497524.1_Missense_Mutation_p.D17N|AGTR1_ENST00000402260.1_Missense_Mutation_p.D17N|AGTR1_ENST00000474935.1_Missense_Mutation_p.D17N	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	17					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	AATCCAAGATGATTGTCCCAA	0.368000													17	70					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55525965	55525965	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:55525965C>T	ENST00000310373.3	-	8	1375	c.1348G>A	c.(1348-1350)Gct>Act	p.A450T	GP6_ENST00000333884.2_3'UTR|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000417454.1_3'UTR	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	68					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		CCGTCTGGAGCCCATATTAGA	0.542000													6	28					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70613190	70613190	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:70613190C>T	ENST00000449580.1	+	21	3139	c.3088C>T	c.(3088-3090)Cgc>Tgc	p.R1030C	TAF1_ENST00000423759.1_Missense_Mutation_p.R1051C|TAF1_ENST00000276072.3_Missense_Mutation_p.R1051C|TAF1_ENST00000373790.4_Missense_Mutation_p.R1030C			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1030					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TGATGTGGTGCGCACAATGTC	0.458000													24	91					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74597184	74597184	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:74597184G>A	ENST00000361874.3	-	13	1617	c.1300C>T	c.(1300-1302)Ctg>Ttg	p.L434L	DCTN1_ENST00000409438.1_Silent_p.L300L|DCTN1_ENST00000409567.3_Silent_p.L414L|DCTN1_ENST00000409868.1_Silent_p.L417L|DCTN1_ENST00000394003.3_Silent_p.L427L|DCTN1_ENST00000409240.1_Silent_p.L397L|DCTN1_ENST00000407639.2_Silent_p.L300L	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	434					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding	p.L434V(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						TCAGCACCCAGAGCAGCATCC	0.542000													25	89					0	0	1	0	0
KIAA1143	57456	broad.mit.edu	37	3	44795848	44795848	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:44795848G>A	ENST00000296121.4	-	2	180	c.121C>T	c.(121-123)Cag>Tag	p.Q41*	KIAA1143_ENST00000484437.1_5'UTR	NM_020696.3	NP_065747.1	Q96AT1	K1143_HUMAN	KIAA1143	41								p.Q41K(1)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.00847)|KIRC - Kidney renal clear cell carcinoma(197;0.0465)|Kidney(197;0.0582)		TCTGGGGGCTGAGGCTGAATT	0.408000													8	106					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132159687	132159687	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:132159687C>A	ENST00000511190.1	-	6	3031	c.2562G>T	c.(2560-2562)tgG>tgT	p.W854C	USP26_ENST00000406273.1_Missense_Mutation_p.W854C|USP26_ENST00000370832.1_Missense_Mutation_p.W854C	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	854					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					CGTAAGTGAACCAGATCTGTT	0.453000													45	119					1.23713e-20	1.35853e-20	1	1	0
CARD8	22900	broad.mit.edu	37	19	48715113	48715113	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:48715113C>G	ENST00000391898.3	-	11	1510	c.1468G>C	c.(1468-1470)Gag>Cag	p.E490Q	CARD8_ENST00000521613.1_Missense_Mutation_p.E440Q|CARD8_ENST00000520753.1_3'UTR|CARD8_ENST00000520153.1_Missense_Mutation_p.E440Q|CARD8_ENST00000519940.1_Missense_Mutation_p.E490Q|CARD8_ENST00000520015.1_3'UTR|CARD8_ENST00000447740.2_Missense_Mutation_p.E440Q|CARD8_ENST00000359009.4_Missense_Mutation_p.E384Q|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000357778.5_Intron|CTC-453G23.8_ENST00000595201.1_RNA	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	384					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		TTTTCCTGCTCCACCAGCTCC	0.542000													19	222					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210561334	210561334	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:210561334G>C	ENST00000360351.4	+	8	4755	c.4249G>C	c.(4249-4251)Gct>Cct	p.A1417P	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000475600.1_3'UTR|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.A1413P	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1417					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TGAAAAGGAAGCTCGGAGATC	0.388000													7	93					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6377809	6377809	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:6377809C>T	ENST00000262483.8	-	10	1288	c.1201G>A	c.(1201-1203)Ggc>Agc	p.G401S	ACKR6_ENST00000421306.3_Missense_Mutation_p.G365S	NM_031220.3	NP_112497.2																					AGTGGCGAGCCGAAGAGGAAG	0.672000													5	20					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45954317	45954317	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:45954317C>T	ENST00000260324.7	+	3	785	c.399C>T	c.(397-399)gaC>gaT	p.D133D	RP11-96O20.4_ENST00000564080.1_Silent_p.D133D|SQRDL_ENST00000568606.1_Silent_p.D133D	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	133							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		CAGATGACGACGAGAAGGTAA	0.443000													13	72					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136803	80136803	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:80136803C>T	ENST00000466387.1	+	11	1660	c.936C>T	c.(934-936)agC>agT	p.S312S	CTNNA2_ENST00000541047.1_Silent_p.S312S|CTNNA2_ENST00000361291.4_Silent_p.S346S|CTNNA2_ENST00000402739.4_Silent_p.S312S|CTNNA2_ENST00000540488.1_Silent_p.S312S|CTNNA2_ENST00000496558.1_Silent_p.S312S			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	312					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GCATCATCAGCGGCGCAGCGC	0.642000													18	77					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121435467	121435467	+	Splice_Site	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:121435467C>T	ENST00000257555.6	+	7	1726	c.1501_splice	c.e7+1	p.H500_splice	HNF1A_ENST00000544413.1_Splice_Site_p.H500_splice|HNF1A_ENST00000402929.1_3'UTR|HNF1A_ENST00000400024.2_Silent_p.H500H|HNF1A_ENST00000541395.1_Splice_Site_p.H500_splice|HNF1A_ENST00000538626.1_Silent_p.H82H			P20823	HNF1A_HUMAN	HNF1 homeobox A	500					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAGCCCCCACGGTGAGCGCC	0.627000									Hepatic Adenoma, Familial Clustering of				3	19					0	0	1	0	0
NFKB1	4790	broad.mit.edu	37	4	103534694	103534694	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:103534694C>A	ENST00000226574.4	+	23	3172	c.2705C>A	c.(2704-2706)gCc>gAc	p.A902D	NFKB1_ENST00000600343.1_Missense_Mutation_p.A721D|NFKB1_ENST00000394820.4_Missense_Mutation_p.A901D|NFKB1_ENST00000505458.1_Missense_Mutation_p.A901D	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	901	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	ACCTCTCAGGCCCACTCGCTG	0.542000													10	42					4.68919e-08	4.91946e-08	1	1	0
RPRD2	23248	broad.mit.edu	37	1	150443841	150443841	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:150443841G>C	ENST00000401000.4	+	10	2404	c.2339G>C	c.(2338-2340)gGa>gCa	p.G780A	RPRD2_ENST00000369068.4_Missense_Mutation_p.G806A|RPRD2_ENST00000539519.1_Missense_Mutation_p.G780A|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	806	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CCTTCTGATGGAATGGAGAGA	0.458000													14	43					0	0	1	0	0
ZNF763	284390	broad.mit.edu	37	19	12089301	12089301	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:12089301C>G	ENST00000343949.5	+	4	726	c.571C>G	c.(571-573)Cga>Gga	p.R191G	ZNF763_ENST00000538752.1_Missense_Mutation_p.R208G|ZNF763_ENST00000590798.1_Missense_Mutation_p.R208G|ZNF763_ENST00000358987.3_Missense_Mutation_p.R188G|ZNF763_ENST00000545530.1_Missense_Mutation_p.R66G	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						TTCAGGCATTCGAAGACGCAT	0.403000													22	166					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89341312	89341312	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr16:89341312C>T	ENST00000301030.4	-	11	8083	c.7623G>A	c.(7621-7623)gcG>gcA	p.A2541A	ANKRD11_ENST00000378330.2_Silent_p.A2541A	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2541						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGGTCCTGGCCGCCCGGCAGT	0.622000													18	54					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935644	151935644	+	Missense_Mutation	SNP	A	A	C	rs35845634	byFrequency	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:151935644A>C	ENST00000393902.3	-	3	1090	c.523T>G	c.(523-525)Ttg>Gtg	p.L175V	MAGEA3_ENST00000370278.3_Missense_Mutation_p.L175V			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	175	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					AAGATGTACAAGTGGCCGATG	0.532000													30	180					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32474719	32474719	+	Silent	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:32474719C>A	ENST00000404025.2	-	5	2702	c.2214G>T	c.(2212-2214)ctG>ctT	p.L738L	NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.L738L|NLRC4_ENST00000360906.5_Silent_p.L738L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	738					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCAAGGTTTTCAGGTTTGTTA	0.408000													37	309					2.05212e-20	2.24301e-20	1	1	0
FAM155A	728215	broad.mit.edu	37	13	108518288	108518288	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr13:108518288C>T	ENST00000375915.2	-	1	795	c.657G>A	c.(655-657)tcG>tcA	p.S219S		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	219						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GGTAAAAATCCGACAAGTTCC	0.577000													20	73					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88822525	88822525	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:88822525G>C	ENST00000277865.4	-	6	905	c.809C>G	c.(808-810)tCt>tGt	p.S270C	GLUD1_ENST00000544149.1_Missense_Mutation_p.S137C|GLUD1_ENST00000537649.1_Missense_Mutation_p.S103C	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	270			S -> C (in HHF6; diminished sensitivity to GTP).		glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	GCCAGTAGCAGAGATGCGTCC	0.433000													6	49					0	0	1	0	0
ZFAND5	7763	broad.mit.edu	37	9	74975561	74975561	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:74975561C>T	ENST00000237937.3	-	2	691	c.134G>A	c.(133-135)gGc>gAc	p.G45D	ZFAND5_ENST00000376962.5_Missense_Mutation_p.G45D|ZFAND5_ENST00000488164.1_5'UTR|ZFAND5_ENST00000376960.4_Missense_Mutation_p.G45D|ZFAND5_ENST00000343431.2_Missense_Mutation_p.G45D	NM_001102421.1|NM_001278243.1|NM_001278244.1|NM_001278245.1|NM_006007.2	NP_001095891.1|NP_001265172.1|NP_001265173.1|NP_001265174.1|NP_005998.1	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	45							DNA binding|zinc ion binding			cervix(1)|kidney(2)|lung(2)|prostate(1)	6						GCTCATTCTGCCACTATTTTG	0.413000													42	222					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19737462	19737462	+	Silent	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr21:19737462G>T	ENST00000284885.3	-	7	801	c.768C>A	c.(766-768)atC>atA	p.I256I		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	256	CUB 1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						ATTACCGTATGATCCACTGGC	0.353000													9	103					7.48243e-07	7.74613e-07	1	1	0
PLIN4	729359	broad.mit.edu	37	19	4511710	4511710	+	Silent	SNP	A	A	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:4511710A>G	ENST00000301286.3	-	3	2219	c.2220T>C	c.(2218-2220)acT>acC	p.T740T		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	740	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CAGACTTTGTAGTGTCCAGGC	0.587000													31	302					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128415	151128415	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:151128415C>G	ENST00000370325.1	-	6	733	c.680G>C	c.(679-681)tGg>tCg	p.W227S	GABRE_ENST00000370328.3_Missense_Mutation_p.W227S|GABRE_ENST00000393914.3_Missense_Mutation_p.W34S			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	227					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GAAATTTTCCCACTTGTAGAT	0.413000													30	105					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139904519	139904519	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:139904519G>A	ENST00000265662.5	-	42	6558	c.6411C>T	c.(6409-6411)gaC>gaT	p.D2137D	ABCA2_ENST00000371605.3_Silent_p.D2136D|ABCA2_ENST00000341511.6_Silent_p.D2137D			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	2136	ABC transporter 2.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGAACAGCGCGTCACACTGCG	0.697000													3	14					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026810	62026810	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:62026810C>T	ENST00000578147.1	-	15	3008	c.2932G>A	c.(2932-2934)Gag>Aag	p.E978K	SCN4A_ENST00000435607.1_Missense_Mutation_p.E978K			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	978					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCCTGCTCCTCAGGGTCCTCC	0.652000													4	31					0	0	1	0	0
FAM186B	84070	broad.mit.edu	37	12	49993562	49993562	+	Missense_Mutation	SNP	G	G	A	rs139362702	byFrequency	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:49993562G>A	ENST00000544141.1	-	4	2190	c.1591C>T	c.(1591-1593)Cgg>Tgg	p.R531W	FAM186B_ENST00000551047.1_Intron|FAM186B_ENST00000257894.2_Missense_Mutation_p.R621W			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	621						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGGCGGGTCCGTGGTCTGTAG	0.567000													18	120					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842961	35842961	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:35842961C>T	ENST00000246553.2	+	1	517	c.507C>T	c.(505-507)gtC>gtT	p.V169V		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	169					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GCTCTCCGGTCTGCCTGGAGG	0.647000													15	37					0	0	1	0	0
IQSEC2	23096	broad.mit.edu	37	X	53268428	53268428	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:53268428G>A	ENST00000396435.3	-	11	3264	c.3064C>T	c.(3064-3066)Cgt>Tgt	p.R1022C	IQSEC2_ENST00000375365.2_Missense_Mutation_p.R817C|IQSEC2_ENST00000375368.5_Missense_Mutation_p.R1012C	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	1012	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						AAAGACTGACGGAAACTGTAC	0.507000											OREG0019800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	62					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56648679	56648679	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:56648679G>A	ENST00000267116.7	-	6	641	c.520C>T	c.(520-522)Cgg>Tgg	p.R174W		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	174							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGAGGCTGCCGCTCCTTTTTG	0.493000													39	82					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													6	141					0	0	1	0	0
SSX7	280658	broad.mit.edu	37	X	52681920	52681920	+	Splice_Site	SNP	C	C	G	rs141868047		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:52681920C>G	ENST00000298181.5	-	3	342	c.184_splice	c.e3+1	p.G62_splice		NM_173358.2	NP_775494.1	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	62	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|skin(1)	16	Ovarian(276;0.236)					TTTCTGTTACCTAGTTTAGTC	0.413000													16	169					0	0	1	0	0
MAN1A2	10905	broad.mit.edu	37	1	117944812	117944812	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:117944812G>A	ENST00000356554.3	+	2	1042	c.307G>A	c.(307-309)Gag>Aag	p.E103K	MAN1A2_ENST00000482811.1_Intron	NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	103					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.E103Q(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TCACAGGGAAGAGGAAGAACG	0.363000													6	76					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42877782	42877782	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr13:42877782C>T	ENST00000025301.2	+	8	5075	c.4900C>T	c.(4900-4902)Cat>Tat	p.H1634Y		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1634					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TAGGATTTTTCATCTCAGTGT	0.423000													30	100					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650440	121650440	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:121650440G>T	ENST00000393386.2	+	12	1751	c.1340G>T	c.(1339-1341)aGa>aTa	p.R447I	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.R447I	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	447					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AATCCTGGTAGAGACAGTGCT	0.398000													15	104					3.45872e-05	3.54934e-05	1	1	0
C1orf101	257044	broad.mit.edu	37	1	244681979	244681979	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:244681979C>T	ENST00000366534.4	+	8	569	c.515C>T	c.(514-516)tCa>tTa	p.S172L	C1orf101_ENST00000473875.1_Intron|C1orf101_ENST00000366533.4_Missense_Mutation_p.S172L|C1orf101_ENST00000366531.3_Missense_Mutation_p.S21L	NM_001130957.1	NP_001124429.1	Q5SY80	CA101_HUMAN	chromosome 1 open reading frame 101	172						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	36	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			GTTTATTCTTCAAATGAGAAA	0.294000													10	62					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178947838	178947838	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:178947838T>A	ENST00000263967.3	+	19	2870	c.2713T>A	c.(2713-2715)Tgt>Agt	p.C905S		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	905	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGCTGGATACTGTGTAGCTAC	0.373000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			76	214					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815351	43815351	+	Silent	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:43815351T>C	ENST00000382031.1	+	5	2425	c.2394T>C	c.(2392-2394)ccT>ccC	p.P798P	MAP1A_ENST00000300231.5_Silent_p.P560P|MAP1A_ENST00000399453.1_Silent_p.P560P			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	560						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCCATTCCCTCTAGACACTG	0.537000													23	64					0	0	1	0	0
ERF	2077	broad.mit.edu	37	19	42754072	42754072	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:42754072G>A	ENST00000222329.4	-	3	437	c.280C>T	c.(280-282)Ctg>Ttg	p.L94L	ERF_ENST00000440177.2_Silent_p.L19L|AC006486.9_ENST00000594664.1_Intron	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	94					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GTCTTGTGCAGAATGCGCTTG	0.473000													34	182					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91805805	91805805	+	Splice_Site	SNP	A	A	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:91805805A>G	ENST00000389857.6	-	8	712	c.624_splice	c.e8-1	p.L209_splice		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	209					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GTCCACGATCAGCTGCAGCCG	0.602000													3	14					0	0	1	0	0
RNF141	50862	broad.mit.edu	37	11	10540606	10540606	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:10540606A>G	ENST00000265981.2	-	5	659	c.517T>C	c.(517-519)Ttt>Ctt	p.F173L	RNF141_ENST00000528665.1_Missense_Mutation_p.F173L	NM_016422.3	NP_057506.2	Q8WVD5	RN141_HUMAN	ring finger protein 141	173							zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		TTCTGACAAAAGCTGTGAGCA	0.468000													4	40					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94640110	94640110	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:94640110C>T	ENST00000260526.6	-	23	3283	c.3101G>A	c.(3100-3102)aGa>aAa	p.R1034K		NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	1034					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCTGCCATTTCTCTCATTAGG	0.398000													22	136					0	0	1	0	0
PACS2	23241	broad.mit.edu	37	14	105821444	105821444	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:105821444G>C	ENST00000447393.1	+	4	528	c.353G>C	c.(352-354)aGa>aCa	p.R118T	PACS2_ENST00000430725.2_Missense_Mutation_p.R51T|PACS2_ENST00000547217.1_Missense_Mutation_p.R88T|PACS2_ENST00000325438.8_Missense_Mutation_p.R118T|PACS2_ENST00000458164.2_Missense_Mutation_p.R118T	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	118					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		CTGCAGCGCAGAAAGCGCTAC	0.607000													7	37					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32740385	32740385	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:32740385C>T	ENST00000333070.4	+	3	253	c.153C>T	c.(151-153)taC>taT	p.Y51Y	LCK_ENST00000373564.3_Silent_p.Y51Y|LCK_ENST00000336890.5_Silent_p.Y51Y	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	51	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TGGTTACCTACGAAGGCTCCA	0.612000			T	TRB@	T-ALL								4	35					0	0	1	0	0
LRRC75A-AS1	125144	broad.mit.edu	37	17	16342471	16342471	+	RNA	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:16342471C>T	ENST00000475953.1	+	0	113				C17orf76-AS1_ENST00000584926.1_RNA|C17orf76-AS1_ENST00000578380.2_RNA|C17orf76-AS1_ENST00000487066.1_RNA|C17orf76-AS1_ENST00000470491.2_RNA|C17orf76-AS1_ENST00000492250.1_RNA|C17orf76-AS1_ENST00000579473.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000580180.1_RNA|C17orf76-AS1_ENST00000582911.1_RNA|C17orf76-AS1_ENST00000475947.2_RNA|C17orf76-AS1_ENST00000584141.1_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000581913.1_RNA|C17orf76-AS1_ENST00000481898.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000477249.2_RNA|C17orf76-AS1_ENST00000584177.1_RNA	NR_027667.1																						CCCGGGAAGCCTGTCTAGAGG	0.642000													11	61					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101266643	101266643	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr13:101266643C>T	ENST00000342624.5	-	16	2136	c.1878G>A	c.(1876-1878)tgG>tgA	p.W626*	TMTC4_ENST00000376234.3_Nonsense_Mutation_p.W607*|TMTC4_ENST00000328767.5_Nonsense_Mutation_p.W496*	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	607						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGCATTTCTCCACGCATTCA	0.448000													29	95					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610554	10610554	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:10610554G>A	ENST00000171111.5	-	2	703	c.156C>T	c.(154-156)ttC>ttT	p.F52F	KEAP1_ENST00000393623.2_Silent_p.F52F	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGGTGTAGCTGAAGGTGCGGT	0.617000													9	112					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130743867	130743867	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:130743867C>G	ENST00000264992.3	-	3	725	c.284G>C	c.(283-285)aGa>aCa	p.R95T	ASTE1_ENST00000514044.1_Missense_Mutation_p.R95T	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	95					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						CTCTCTAGCTCTATCCTTTAA	0.393000													4	73					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58831438	58831438	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:58831438G>A	ENST00000355431.3	+	20	3004	c.2631G>A	c.(2629-2631)atG>atA	p.M877I	ARID4A_ENST00000431317.2_Missense_Mutation_p.M877I|ARID4A_ENST00000395168.3_Missense_Mutation_p.M877I|ARID4A_ENST00000348476.3_Missense_Mutation_p.M877I	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	877					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GAATGGAAATGACAAATACTG	0.328000													10	50					0	0	1	0	0
UNC50	25972	broad.mit.edu	37	2	99226346	99226346	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:99226346C>T	ENST00000409975.1	+	1	1305	c.175C>T	c.(175-177)Cgg>Tgg	p.R59W	UNC50_ENST00000357765.2_Missense_Mutation_p.R42W|UNC50_ENST00000409347.1_Missense_Mutation_p.R59W			Q53HI1	UNC50_HUMAN	unc-50 homolog (C. elegans)	42					protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding			breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)	10						TTTCCGCTTTCGGCAAATGGA	0.473000													8	174					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1264618	1264618	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:1264618C>T	ENST00000310581.5	-	11	2801	c.2744G>A	c.(2743-2745)gGt>gAt	p.G915D	TERT_ENST00000296820.5_3'UTR|TERT_ENST00000334602.6_Intron	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	915	Required for oligomerization.|Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGCCGTGCCACCCAGGGCCTC	0.622000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				11	52					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	rs149680468		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:153247289G>C	ENST00000281708.4	-	10	2742	c.1513C>G	c.(1513-1515)Cgc>Ggc	p.R505G	FBXW7_ENST00000296555.5_Missense_Mutation_p.R387G|FBXW7_ENST00000263981.5_Missense_Mutation_p.R425G|FBXW7_ENST00000603548.1_Missense_Mutation_p.R505G|FBXW7_ENST00000603841.1_Missense_Mutation_p.R505G|FBXW7_ENST00000393956.3_Missense_Mutation_p.R329G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	505			R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R505C(60)|p.R505G(18)|p.R425C(14)|p.R266C(13)|p.R425G(9)|p.R266G(9)|p.R387G(6)|p.R387C(3)|p.R505S(3)|p.R387S(1)|p.?(1)|p.R425S(1)|p.R266S(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								21	91					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7793095	7793095	+	Splice_Site	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:7793095G>T	ENST00000380358.4	+	2	391		c.e2+1		CHD3_ENST00000358181.4_Splice_Site|CHD3_ENST00000330494.7_Splice_Site|CHD3_ENST00000570758.1_Splice_Site	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CAAGAAGCGTGTAAGTGTCAA	0.507000													16	33					6.31663e-08	6.59737e-08	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140482233	140482233	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:140482233C>G	ENST00000231130.2	+	1	2000	c.2000C>G	c.(1999-2001)tCc>tGc	p.S667C		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		667	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACGGCTTCTCCCAGCCCTAC	0.692000													16	138					0	0	1	0	0
CCDC112	153733	broad.mit.edu	37	5	114611171	114611171	+	Silent	SNP	A	A	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:114611171A>T	ENST00000379611.5	-	6	947	c.660T>A	c.(658-660)ccT>ccA	p.P220P	CCDC112_ENST00000512261.1_Silent_p.P137P|CCDC112_ENST00000503027.1_5'UTR|CCDC112_ENST00000506442.1_Silent_p.P137P|CCDC112_ENST00000395557.4_Silent_p.P137P	NM_001040440.2	NP_001035530.1	Q8NEF3	CC112_HUMAN	coiled-coil domain containing 112	137										endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|skin(1)	20		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		CTTTGTCTACAGGAACTTTGC	0.403000													42	142					0	0	1	0	0
LCN15	389812	broad.mit.edu	37	9	139658213	139658213	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:139658213C>G	ENST00000316144.5	-	3	283	c.259G>C	c.(259-261)Gat>Cat	p.D87H	LCN15_ENST00000482511.1_5'UTR	NM_203347.1	NP_976222.1	Q6UWW0	LCN15_HUMAN	lipocalin 15	87					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|lung(1)	2						TACTCGGCATCCACCTGGTTA	0.672000													7	32					0	0	1	0	0
SMG6	23293	broad.mit.edu	37	17	2203825	2203825	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:2203825G>C	ENST00000544865.1	-	2	639	c.129C>G	c.(127-129)ttC>ttG	p.F43L	SMG6_ENST00000263073.5_Missense_Mutation_p.F74L			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	74					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TTTCATCTTTGAATTCCTCAC	0.453000													33	185					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106555311	106555311	+	Missense_Mutation	SNP	C	C	G	rs149770989		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:106555311C>G	ENST00000369096.4	+	7	2662	c.2428C>G	c.(2428-2430)Ctg>Gtg	p.L810V	PRDM1_ENST00000369091.2_Missense_Mutation_p.L774V|PRDM1_ENST00000369089.3_Missense_Mutation_p.L676V	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	810					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CCCACTACCTCTGGTACCTGT	0.433000			"""D, N, Mis, F, S"""		DLBCL								16	103					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879277	149879277	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:149879277G>A	ENST00000369146.3	-	10	2143	c.1653C>T	c.(1651-1653)ttC>ttT	p.F551F	SV2A_ENST00000369145.1_Silent_p.F551F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	551					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAGTGTTGATGAATGTGCAGT	0.483000													15	121					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56086664	56086664	+	Silent	SNP	T	T	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:56086664T>G	ENST00000257880.7	-	22	3159	c.2940A>C	c.(2938-2940)ccA>ccC	p.P980P	ITGA7_ENST00000452168.2_Silent_p.P843P|ITGA7_ENST00000394230.2_Silent_p.P940P|ITGA7_ENST00000553804.1_Silent_p.P940P|ITGA7_ENST00000347027.6_Silent_p.P930P|ITGA7_ENST00000555728.1_Silent_p.P980P|ITGA7_ENST00000257879.6_Silent_p.P936P|ITGA7_ENST00000394229.2_Silent_p.P936P			Q13683	ITA7_HUMAN	integrin, alpha 7	980					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGAGGACACTGGCCACCAGG	0.637000													7	20					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524602	187524602	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:187524602T>C	ENST00000441802.2	-	19	11287	c.11078A>G	c.(11077-11079)gAc>gGc	p.D3693G		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3693					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AAGTAAGACGTCCAGATGTGG	0.453000										HNSCC(5;0.00058)			14	40					0	0	1	0	0
SGPP1	81537	broad.mit.edu	37	14	64194623	64194623	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:64194623G>C	ENST00000247225.6	-	1	134	c.40C>G	c.(40-42)Ctg>Gtg	p.L14V		NM_030791.2	NP_110418.1	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	14						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	10				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		GGGTCCTGCAGACGGCCAACC	0.721000													3	5					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228402696	228402696	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:228402696C>T	ENST00000570156.2	+	5	1799	c.1725C>T	c.(1723-1725)acC>acT	p.T575T	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.T575T|OBSCN_ENST00000422127.1_Silent_p.T575T|OBSCN_ENST00000366707.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	575	Fibronectin type-III 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGAGCTGACCGTGGCTGATG	0.587000													11	25					0	0	1	0	0
SEPT6	23157	broad.mit.edu	37	X	118787004	118787004	+	Splice_Site	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:118787004C>T	ENST00000394610.1	-	4	606		c.e4-1		SEPT6_ENST00000394617.2_Splice_Site|SEPT6_ENST00000354416.3_Splice_Site|SEPT6_ENST00000394616.4_Splice_Site|SEPT6_ENST00000343984.5_Splice_Site|SEPT6_ENST00000354228.4_Splice_Site|SEPT6_ENST00000360156.7_Splice_Site|SEPT6_ENST00000489216.1_Splice_Site	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6						cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						AGGCTTGTAGCTAAAAGGGAG	0.483000			T	MLL	AML								15	76					0	0	1	0	0
SEC13	6396	broad.mit.edu	37	3	10357041	10357041	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:10357041C>T	ENST00000397117.1	-	3	677	c.86G>A	c.(85-87)cGc>cAc	p.R29H	SEC13_ENST00000397109.3_Missense_Mutation_p.R29H|SEC13_ENST00000337354.4_Missense_Mutation_p.R46H|SEC13_ENST00000383801.2_Missense_Mutation_p.R89H|SEC13_ENST00000350697.3_Missense_Mutation_p.R43H			P55735	SEC13_HUMAN	SEC13 homolog (S. cerevisiae)	43					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding	p.R43H(1)		NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17						CCCTCCATTGCGCACATCAAA	0.592000													9	33					0	0	1	0	0
GLTP	51228	broad.mit.edu	37	12	110290475	110290475	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:110290475G>A	ENST00000318348.4	-	5	628	c.515C>T	c.(514-516)aCg>aTg	p.T172M	GLTP_ENST00000544393.1_Missense_Mutation_p.T153M	NM_016433.3	NP_057517.1	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	172						cytoplasm	glycolipid binding|glycolipid transporter activity			endometrium(1)|kidney(1)|lung(1)|upper_aerodigestive_tract(1)	4		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		CTCCTCCTCCGTAACATTCTG	0.542000											OREG0022112	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	304					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53215501	53215501	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:53215501C>T	ENST00000394729.2	+	5	746	c.418C>T	c.(418-420)Cca>Tca	p.P140S	PRKCD_ENST00000330452.3_Missense_Mutation_p.P140S	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	140					activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GGCCAAGTTCCCAACGATGAA	0.537000													9	39					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:21971120G>A	ENST00000304494.5	-	2	508	c.238C>T	c.(238-240)Cga>Tga	p.R80*	CDKN2A_ENST00000579755.1_Missense_Mutation_p.P94L|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P94L|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P135L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R29*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R80*(100)|p.?(44)|p.P135L(7)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	14					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31066223	31066223	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr21:31066223G>A	ENST00000399914.1	-	2	799	c.278C>T	c.(277-279)tCg>tTg	p.S93L	GRIK1_ENST00000389124.2_Missense_Mutation_p.S93L|GRIK1_ENST00000399907.1_Missense_Mutation_p.S93L|GRIK1_ENST00000399913.1_Missense_Mutation_p.S93L|GRIK1_ENST00000399909.1_Missense_Mutation_p.S93L|GRIK1_ENST00000535441.1_Missense_Mutation_p.S93L|GRIK1_ENST00000389125.3_Missense_Mutation_p.S93L|GRIK1_ENST00000309434.7_Missense_Mutation_p.S93L|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000327783.4_Missense_Mutation_p.S93L			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	93					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	ACCTCTCCGCGAGGCTTCAAA	0.423000													22	86					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154569319	154569319	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:154569319G>C	ENST00000368474.4	-	6	2431	c.2232C>G	c.(2230-2232)ttC>ttG	p.F744L	ADAR_ENST00000292205.5_Missense_Mutation_p.F787L|ADAR_ENST00000368471.3_Missense_Mutation_p.F449L	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	744	DRBM 3.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CGACCAACTTGAATTCAGCAG	0.562000													9	71					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40360117	40360117	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:40360117G>A	ENST00000338305.6	-	3	2477	c.1935C>T	c.(1933-1935)tcC>tcT	p.S645S		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	645						cell junction|integral to membrane|postsynaptic membrane		p.S645S(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGCGCGGGGCGGAGGGTGGGA	0.711000													4	15					0	0	1	0	0
MXI1	4601	broad.mit.edu	37	10	111988081	111988081	+	Splice_Site	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:111988081T>C	ENST00000332674.5	+	2	611		c.e2+2		MXI1_ENST00000369612.1_Splice_Site|MXI1_ENST00000361248.4_Splice_Site|MXI1_ENST00000393134.1_Splice_Site|MXI1_ENST00000485566.1_Splice_Site|MXI1_ENST00000239007.7_Splice_Site	NM_130439.3	NP_569157.2	P50539	MXI1_HUMAN	MAX interactor 1, dimerization protein						cytoplasmic sequestering of transcription factor|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(1)	10		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;1.33e-05)|all cancers(201;0.000277)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TGCCAACAGGTAGCAAGCTGG	0.572000													4	37					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180043378	180043378	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:180043378G>A	ENST00000261937.6	-	23	3286	c.3208C>T	c.(3208-3210)Cgc>Tgc	p.R1070C	FLT4_ENST00000393347.3_Missense_Mutation_p.R1070C|FLT4_ENST00000502649.1_Missense_Mutation_p.R1070C	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1070	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGCCCTTGCGGACGTAGTCG	0.602000													10	52					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14938848	14938848	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:14938848G>A	ENST00000322301.3	-	2	293	c.206C>T	c.(205-207)gCt>gTt	p.A69V	OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_Missense_Mutation_p.A69V			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						ACAAATGTCAGCAAAGGACAG	0.493000													17	143					0	0	1	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364624	142364624	+	RNA	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:142364624C>T	ENST00000390397.2	+	0	295																											CAGTGTCTCTCGACAGGCACA	0.478000													7	26					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39794930	39794930	+	Silent	SNP	C	C	G	rs139798242	by1000genomes	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr20:39794930C>G	ENST00000373272.2	+	17	2301	c.1896C>G	c.(1894-1896)ctC>ctG	p.L632L	PLCG1_ENST00000373271.1_Silent_p.L632L|PLCG1_ENST00000244007.3_Silent_p.L632L	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	632	SH2 1.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				TTGACTCCCTCTATGACCTCA	0.567000													13	63					0	0	1	0	0
LSR	51599	broad.mit.edu	37	19	35757744	35757744	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:35757744C>T	ENST00000602122.1	+	7	1589	c.1102C>T	c.(1102-1104)Cgc>Tgc	p.R368C	LSR_ENST00000354900.3_Missense_Mutation_p.R369C|LSR_ENST00000360798.3_Missense_Mutation_p.R320C|LSR_ENST00000427250.1_Missense_Mutation_p.R232C|LSR_ENST00000347609.4_Missense_Mutation_p.R330C|LSR_ENST00000361790.3_Missense_Mutation_p.R388C			Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	388					embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCTAGAAGTCCGCAGTGGCTA	0.602000													6	11					0	0	1	0	0
GABARAPL1	23710	broad.mit.edu	37	12	10374431	10374431	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:10374431G>C	ENST00000546017.1	+	4	1003	c.64G>C	c.(64-66)Gag>Cag	p.E22Q	GABARAPL1_ENST00000266458.5_Missense_Mutation_p.E112Q|GABARAPL1_ENST00000545887.1_Missense_Mutation_p.E112Q|GABARAPL1_ENST00000544284.1_Missense_Mutation_p.E22Q|GABARAPL1_ENST00000539170.1_Missense_Mutation_p.E22Q|GABARAPL1_ENST00000535576.1_Missense_Mutation_p.E22Q			Q9H0R8	GBRL1_HUMAN	GABA(A) receptor-associated protein like 1	112	Interaction with beta-tubulin (By similarity).					autophagic vacuole|endoplasmic reticulum|Golgi apparatus|membrane|microtubule	beta-tubulin binding|GABA receptor binding			NS(1)|lung(1)	2						CTACAGTGATGAGAGTGTCTA	0.478000													5	54					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233028272	233028272	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:233028272C>G	ENST00000325385.7	+	9	1330	c.1054C>G	c.(1054-1056)Cta>Gta	p.L352V	DIS3L2_ENST00000273009.6_Missense_Mutation_p.L352V|DIS3L2_ENST00000409307.1_Missense_Mutation_p.L352V	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	352							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TTCAGAAGTTCTAGAATGTCT	0.453000													9	40					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69666071	69666071	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:69666071G>C	ENST00000370598.1	+	7	2172	c.1351G>C	c.(1351-1353)Gaa>Caa	p.E451Q		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	451	TSP type-1 3.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CTATAACCCTGAATGTACAGG	0.512000													12	32					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241835205	241835205	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:241835205G>A	ENST00000388934.4	-	1	368	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_001085437.1	NP_001078906.1	Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	70										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AGCGCAGGGCGAACTGGAAGG	0.657000													10	30					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005808	74005808	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:74005808C>T	ENST00000301607.3	-	22	3731	c.3478G>A	c.(3478-3480)Gag>Aag	p.E1160K	EVPL_ENST00000586740.1_Missense_Mutation_p.E1182K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1160	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTCTCCTCCTCGAGGAGGCTC	0.622000													8	56					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70375176	70375176	+	Silent	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:70375176C>G	ENST00000374051.3	+	4	952	c.630C>G	c.(628-630)gtC>gtG	p.V210V	NLGN3_ENST00000536169.1_Silent_p.V190V|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000358741.3_Silent_p.V230V	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	230					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity	p.V230V(1)|p.V210V(1)		biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					ATGGCAATGTCATCGTCATCA	0.542000													6	105					0	0	1	0	0
NDUFS5	4725	broad.mit.edu	37	1	39494450	39494450	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:39494450G>C	ENST00000372969.3	+	2	141	c.54G>C	c.(52-54)ttG>ttC	p.L18F	NDUFS5_ENST00000372967.3_Missense_Mutation_p.L18F	NM_004552.2	NP_004543.1	O43920	NDUS5_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	18					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|large_intestine(2)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.93e-18)		NADH(DB00157)	ATCGATGGTTGACAATCCAGA	0.408000													8	110					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241659322	241659322	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:241659322C>T	ENST00000498729.2	-	46	5136	c.4890G>A	c.(4888-4890)cgG>cgA	p.R1630R	KIF1A_ENST00000320389.7_Silent_p.R1529R	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1529	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGCTGGCTGGCCGGGAGCAGG	0.706000													4	33					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836061	43836061	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr20:43836061C>T	ENST00000372781.3	+	2	180	c.123C>T	c.(121-123)caC>caT	p.H41H	SEMG1_ENST00000244069.6_Silent_p.H41H	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				AATTTCCACACGGACAAAAGG	0.393000													24	126					0	0	1	0	0
SPIN4	139886	broad.mit.edu	37	X	62570071	62570071	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:62570071C>G	ENST00000374884.2	-	1	1152	c.574G>C	c.(574-576)Gat>Cat	p.D192H	SPIN4-AS1_ENST00000451979.1_RNA|SPIN4_ENST00000335144.3_Missense_Mutation_p.D210H			Q56A73	SPIN4_HUMAN	spindlin family, member 4	210					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						GACCCGTCATCTTTGGCATGC	0.448000													14	109					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67219151	67219151	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr16:67219151G>A	ENST00000314586.6	-	11	1877	c.1637C>T	c.(1636-1638)gCg>gTg	p.A546V		NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	546					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GGGCAGATCCGCGAACAGGGG	0.637000													15	66					0	0	1	0	0
DTD1	92675	broad.mit.edu	37	20	18576734	18576734	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr20:18576734G>C	ENST00000377452.3	+	3	399	c.219G>C	c.(217-219)gaG>gaC	p.E73D	DTD1_ENST00000494921.1_3'UTR	NM_080820.4	NP_543010.3	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	73					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			large_intestine(4)|lung(1)|ovary(2)	7						AACAGTACGAGATTCTGTGTG	0.502000													6	80					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195595418	195595418	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:195595418G>A	ENST00000333602.6	-	12	2323	c.1706C>T	c.(1705-1707)aCg>aTg	p.T569M	TNK2_ENST00000392400.1_Missense_Mutation_p.T569M|TNK2_ENST00000428187.1_Missense_Mutation_p.T601M|TNK2_ENST00000381916.2_Missense_Mutation_p.T647M	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	569				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GTCGATGAGCGTGACCTCAGC	0.751000													6	9					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175689187	175689187	+	Silent	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:175689187G>C	ENST00000409900.3	-	8	1000	c.687C>G	c.(685-687)ctC>ctG	p.L229L	CHN1_ENST00000295497.7_Silent_p.L104L|CHN1_ENST00000409156.3_Silent_p.L203L|CHN1_ENST00000409597.1_Silent_p.L45L|CHN1_ENST00000488080.1_5'UTR	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	229					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCTGAGCAATGAGACCCCACA	0.453000			T	TAF15	extraskeletal myxoid chondrosarcoma								4	23					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034457	52034457	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:52034457C>T	ENST00000346477.3	-	2	452	c.384G>A	c.(382-384)atG>atA	p.M128I	SIGLEC6_ENST00000391797.3_Missense_Mutation_p.M128I|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.M128I|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.M128I|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.M128I|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.M92I	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	128					cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		AACCGTATTTCATCCATTTGG	0.537000													32	123					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153190726	153190726	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:153190726C>A	ENST00000285900.5	+	16	3005	c.2662C>A	c.(2662-2664)Caa>Aaa	p.Q888K	GRIA1_ENST00000340592.5_Missense_Mutation_p.Q888K|GRIA1_ENST00000518142.1_Missense_Mutation_p.Q808K|GRIA1_ENST00000521843.2_Missense_Mutation_p.Q819K|GRIA1_ENST00000448073.4_Missense_Mutation_p.Q898K|GRIA1_ENST00000518783.1_Missense_Mutation_p.Q898K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	888					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CAAGTCCATGCAATCGATTCC	0.627000													15	50					2.61681e-11	2.82088e-11	1	1	0
UVRAG	7405	broad.mit.edu	37	11	75715074	75715074	+	Silent	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:75715074C>G	ENST00000356136.3	+	9	1093	c.852C>G	c.(850-852)ctC>ctG	p.L284L	UVRAG_ENST00000539288.1_5'UTR|UVRAG_ENST00000531818.1_5'UTR|UVRAG_ENST00000533454.1_5'UTR|UVRAG_ENST00000532130.1_5'UTR|UVRAG_ENST00000528420.1_Silent_p.L183L	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	284					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						CTGAGCACCTCAAACTTCAAC	0.418000													42	148					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26943114	26943114	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:26943114C>T	ENST00000381340.3	-	2	555	c.139G>A	c.(139-141)Gcc>Acc	p.A47T	ITPR2_ENST00000242737.5_Missense_Mutation_p.A47T	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	47					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GGAGGGTTGGCAAGGTCCCCG	0.388000													4	100					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154146790	154146790	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:154146790G>A	ENST00000389740.2	-	1	714	c.615C>T	c.(613-615)ctC>ctT	p.L205L		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	205						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGAGGCCCACGAGGAGTCCGA	0.602000													28	93					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11711205	11711205	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:11711205C>A	ENST00000262442.3	+	44	8645	c.8577C>A	c.(8575-8577)gaC>gaA	p.D2859E	DNAH9_ENST00000454412.2_Missense_Mutation_p.D2859E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2859	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGATCCAGGACTTCAAGGTAA	0.557000													5	32					0.014758	0.0150135	1	1	0
CCDC132	55610	broad.mit.edu	37	7	92926149	92926149	+	Splice_Site	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:92926149G>A	ENST00000544910.1	+	16	1392		c.e16+1		CCDC132_ENST00000535481.1_Splice_Site|CCDC132_ENST00000305866.5_Splice_Site|CCDC132_ENST00000541136.1_Splice_Site|CCDC132_ENST00000317751.6_Splice_Site	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132											endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TAATCAGCAGGTAGTATTTAA	0.299000													12	47					0	0	1	0	0
INPP5A	3632	broad.mit.edu	37	10	134563078	134563078	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:134563078G>T	ENST00000368594.3	+	10	1067	c.790G>T	c.(790-792)Gtg>Ttg	p.V264L	INPP5A_ENST00000368593.3_Missense_Mutation_p.V264L	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	264					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CAATGAAGTGGTGAAGCTCAT	0.622000													20	59					1.64293e-13	1.78745e-13	1	1	0
PCDHGC3	5098	broad.mit.edu	37	5	140857005	140857005	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:140857005C>G	ENST00000308177.3	+	1	1426	c.1322C>G	c.(1321-1323)aCa>aGa	p.T441R	PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCCCTTACAATAGTGCGT	0.517000													13	85					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170724960	170724960	+	Missense_Mutation	SNP	C	C	T	rs121909741		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:170724960C>T	ENST00000314251.3	-	5	668	c.589G>A	c.(589-591)Gtc>Atc	p.V197I	SLC2A2_ENST00000382808.4_Missense_Mutation_p.V78I	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	197			V -> I (in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes).		carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity	p.V197I(1)		central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATGCCCGTGACGATGGCCAGC	0.483000													18	34					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677313	62677313	+	Silent	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:62677313G>C	ENST00000306960.3	-	2	1801	c.1260C>G	c.(1258-1260)ctC>ctG	p.L420L	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	420					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTTGTTGCAGAGTGCGTAGC	0.612000													47	151					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179623873	179623873	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:179623873C>G	ENST00000589042.1	-	44	10365	c.10141G>C	c.(10141-10143)Gac>Cac	p.D3381H	TTN_ENST00000342992.6_Missense_Mutation_p.D3381H|TTN_ENST00000342175.6_Missense_Mutation_p.D3335H|TTN_ENST00000359218.5_Missense_Mutation_p.D3335H|TTN_ENST00000591111.1_Missense_Mutation_p.D3381H|TTN_ENST00000360870.5_Missense_Mutation_p.D3381H|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D3335H|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3094	Ig-like 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTCTTGTCTTTGCTGTAC	0.363000													21	100					0	0	1	0	0
MFN2	9927	broad.mit.edu	37	1	12067225	12067225	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:12067225G>T	ENST00000235329.5	+	17	2310	c.1988G>T	c.(1987-1989)cGc>cTc	p.R663L	MFN2_ENST00000444836.1_Missense_Mutation_p.R663L	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	663					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		GCCTTCAAGCGCCAGTTTGTG	0.602000													15	41					6.72482e-11	7.21613e-11	1	1	0
ZDHHC21	340481	broad.mit.edu	37	9	14674322	14674322	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:14674322T>C	ENST00000380916.3	-	4	483	c.17A>G	c.(16-18)cAc>cGc	p.H6R		NM_178566.4	NP_848661.1	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	6					nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9				GBM - Glioblastoma multiforme(50;4.31e-06)		AACAACAAAGTGAATCCGGAG	0.383000													6	142					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132504724	132504724	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:132504724C>T	ENST00000333577.4	+	23	4625	c.4516C>T	c.(4516-4518)Ccg>Tcg	p.P1506S	EP400_ENST00000389562.2_Missense_Mutation_p.P1469S|EP400_ENST00000332482.4_Missense_Mutation_p.P1433S|EP400_ENST00000330386.6_Missense_Mutation_p.P1470S|EP400_ENST00000389561.2_Missense_Mutation_p.P1470S			Q96L91	EP400_HUMAN	E1A binding protein p400	1506					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCGAGGACGGCCGCCCATCGC	0.642000													4	96					0	0	1	0	0
NPM3	10360	broad.mit.edu	37	10	103542039	103542039	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:103542039G>A	ENST00000370110.5	-	4	416	c.394C>T	c.(394-396)Cgg>Tgg	p.R132W	NPM3_ENST00000474993.1_5'UTR	NM_006993.2	NP_008924.1	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	132							nucleic acid binding			large_intestine(3)|lung(1)|skin(1)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		CCAGTGATCCGCACAGGGCCA	0.617000													3	35					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37187536	37187536	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:37187536C>G	ENST00000274258.7	-	23	4290	c.703G>C	c.(703-705)Gaa>Caa	p.E235Q	C5orf42_ENST00000508244.1_Missense_Mutation_p.E1354Q|C5orf42_ENST00000425232.2_Missense_Mutation_p.E1354Q			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1354										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GGTGGCAGTTCTCCAATAAGG	0.338000													6	69					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142430410	142430410	+	Missense_Mutation	SNP	G	G	A	rs146341428		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:142430410G>A	ENST00000337777.3	+	15	1910	c.1697G>A	c.(1696-1698)cGt>cAt	p.R566H	PLS1_ENST00000457734.2_Missense_Mutation_p.R566H|PLS1_ENST00000497002.1_Missense_Mutation_p.R566H	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	566	Actin-binding 2.|CH 4.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						AATGCAGTTCGTCAAGAAATG	0.333000													18	79					0	0	1	0	0
CCDC172	374355	broad.mit.edu	37	10	118101575	118101575	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:118101575G>A	ENST00000333254.3	+	5	561	c.310G>A	c.(310-312)Gag>Aag	p.E104K	CCDC172_ENST00000497093.1_3'UTR	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		AATGATAGAGGAGGAAGACAA	0.234000													15	70					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50959895	50959895	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:50959895C>A	ENST00000374103.4	-	6	812	c.727G>T	c.(727-729)Gcc>Tcc	p.A243S	OGDHL_ENST00000432695.1_Missense_Mutation_p.A34S|OGDHL_ENST00000419399.1_Missense_Mutation_p.A186S	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	243					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ACTAGCCGGGCCAGCAGGGTC	0.607000													21	96					2.27731e-05	2.34722e-05	1	1	0
CEP350	9857	broad.mit.edu	37	1	180053305	180053305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:180053305C>T	ENST00000367607.3	+	31	6695	c.6277C>T	c.(6277-6279)Cag>Tag	p.Q2093*		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2093						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TCTGATCAAGCAGTTAGAGGT	0.373000													3	10					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157551407	157551407	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:157551407A>T	ENST00000271532.1	-	7	1298	c.1163T>A	c.(1162-1164)gTc>gAc	p.V388D	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	388						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TCCCGCGGCGACAAGGCCATC	0.572000													4	24					0	0	1	0	0
VSIG4	11326	broad.mit.edu	37	X	65252479	65252479	+	Silent	SNP	A	A	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:65252479A>G	ENST00000455586.2	-	3	651	c.525T>C	c.(523-525)taT>taC	p.Y175Y	VSIG4_ENST00000412866.2_Intron|VSIG4_ENST00000374737.4_Silent_p.Y175Y	NM_001184830.1	NP_001171759.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	175	Ig-like 2.				complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TATACCAAATATAACTGATGG	0.512000													6	66					0	0	1	0	0
PPTC7	160760	broad.mit.edu	37	12	110977654	110977654	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:110977654C>T	ENST00000354300.3	-	4	987	c.699G>A	c.(697-699)atG>atA	p.M233I		NM_139283.1	NP_644812.1	Q8NI37	PPTC7_HUMAN	PTC7 protein phosphatase homolog (S. cerevisiae)	233	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity			endometrium(1)|large_intestine(2)|lung(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	9						CCTGAAGAATCATATAATCAG	0.433000													9	67					0	0	1	0	0
HHLA3	11147	broad.mit.edu	37	1	70820689	70820689	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:70820689G>A	ENST00000359875.5	+	1	195	c.55G>A	c.(55-57)Gca>Aca	p.A19T	HHLA3_ENST00000370940.5_Missense_Mutation_p.A19T|HHLA3_ENST00000486110.1_3'UTR|HHLA3_ENST00000432224.1_Missense_Mutation_p.A19T|HHLA3_ENST00000361764.4_Missense_Mutation_p.A19T|HHLA3_ENST00000531950.1_Missense_Mutation_p.A19T	NM_001036645.1	NP_001031722.1	Q9XRX5	HHLA3_HUMAN	HERV-H LTR-associating 3	19							protein binding			large_intestine(3)|lung(1)	4						TGAGCCTCCCGCAGAGGAATG	0.522000													11	25					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47535818	47535818	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr21:47535818G>A	ENST00000300527.4	+	6	938	c.834G>A	c.(832-834)gaG>gaA	p.E278E	COL6A2_ENST00000310645.5_Silent_p.E278E|COL6A2_ENST00000397763.1_Silent_p.E278E|COL6A2_ENST00000357838.4_Silent_p.E278E|COL6A2_ENST00000409416.1_Silent_p.E278E	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	278	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGCCGGGAGAGCCTGGCCAGA	0.657000													9	33					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94033378	94033378	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:94033378G>A	ENST00000370244.1	-	12	2293	c.2005C>T	c.(2005-2007)Ctg>Ttg	p.L669L	BCAR3_ENST00000370243.1_Silent_p.L669L|BCAR3_ENST00000370247.3_Silent_p.L578L|BCAR3_ENST00000539242.1_Silent_p.L345L|BCAR3_ENST00000260502.6_Silent_p.L669L	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	669	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TGGTGCCGCAGAGCAGTCCAC	0.488000													8	71					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27278919	27278919	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:27278919C>T	ENST00000360131.4	+	7	1437	c.1278C>T	c.(1276-1278)ggC>ggT	p.G426G	AGBL5_ENST00000323064.8_Silent_p.G426G	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	426					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGAGAGTGGCGTTGCTTACT	0.522000													54	204					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180044257	180044257	+	Missense_Mutation	SNP	C	C	A	rs148196085	byFrequency	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:180044257C>A	ENST00000367607.3	+	28	6086	c.5668C>A	c.(5668-5670)Cgt>Agt	p.R1890S		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1890						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGCAGAAATTCGTCAAATGGA	0.438000													7	23					0.0381472	0.0383103	1	1	0
GPX1	2876	broad.mit.edu	37	3	49394958	49394958	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:49394958C>T	ENST00000419783.1	-	2	796	c.475G>A	c.(475-477)Gat>Aat	p.D159N	GPX1_ENST00000419349.1_3'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	159					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CAGGCAACATCGTTGCGACAC	0.627000													12	48					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81371740	81371740	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:81371740C>T	ENST00000398636.3	+	3	297	c.159C>T	c.(157-159)gaC>gaT	p.D53D	SFTPA1_ENST00000372313.5_Intron|SFTPA1_ENST00000372308.3_Silent_p.D53D|SFTPA1_ENST00000419470.2_Silent_p.D68D|SFTPA1_ENST00000428376.2_Silent_p.D53D	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	53	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCAAAGGAGACCCTGGCCCTC	0.637000													12	44					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	557947	557947	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:557947G>A	ENST00000329451.3	-	5	554	c.492C>T	c.(490-492)ctC>ctT	p.L164L	RP11-496I9.1_ENST00000527620.1_RNA	NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	164										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAGCTGCAGGAGGCAGGACT	0.677000													5	22					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51851063	51851063	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr18:51851063C>T	ENST00000581310.1	-	9	1035	c.662G>A	c.(661-663)tGa>tAa	p.*221*	STARD6_ENST00000307844.3_Silent_p.*221*|STARD6_ENST00000580990.2_Silent_p.*97*			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	0					lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		CTTTTGGTATCATGAATGACT	0.348000													20	86					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89804288	89804288	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr16:89804288C>T	ENST00000289816.5	+	10	1636	c.1324C>T	c.(1324-1326)Cga>Tga	p.R442*	ZNF276_ENST00000443381.2_Nonsense_Mutation_p.R517*|ZNF276_ENST00000446326.2_Nonsense_Mutation_p.R303*|FANCA_ENST00000389301.3_3'UTR|ZNF276_ENST00000568064.1_Nonsense_Mutation_p.R425*	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CCACCAAATGCGACATTCGGG	0.572000													13	66					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90020771	90020771	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr16:90020771C>T	ENST00000563594.1	+	3	1108	c.111C>T	c.(109-111)gaC>gaT	p.D37D	DEF8_ENST00000563795.1_Silent_p.D37D|DEF8_ENST00000570182.1_Silent_p.D37D|DEF8_ENST00000567874.1_Intron|DEF8_ENST00000569453.1_Silent_p.D37D|DEF8_ENST00000268676.7_Silent_p.D98D|DEF8_ENST00000418391.2_Silent_p.D37D	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	98					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		AGGTCCCGGACGTCACTCCTG	0.647000													8	57					0	0	1	0	0
SMC5	23137	broad.mit.edu	37	9	72962884	72962884	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:72962884A>T	ENST00000361138.5	+	22	2877	c.2819A>T	c.(2818-2820)aAt>aTt	p.N940I	SMC5_ENST00000471372.1_3'UTR	NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	940					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						GAAAAAATTAATGAAAAATTC	0.274000													11	53					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223983857	223983857	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:223983857T>C	ENST00000391878.2	-	14	2765	c.1997A>G	c.(1996-1998)aAt>aGt	p.N666S	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000391879.2_Missense_Mutation_p.N28S|TP53BP2_ENST00000343537.7_Missense_Mutation_p.N795S	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	789					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TAAATATGGATTCTGGATTTC	0.512000													22	105					0	0	1	0	0
VEGFB	7423	broad.mit.edu	37	11	64003411	64003411	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:64003411G>A	ENST00000309422.2	+	3	526	c.230G>A	c.(229-231)cGc>cAc	p.R77H	VEGFB_ENST00000426086.2_Missense_Mutation_p.R77H	NM_001243733.1|NM_003377.4	NP_001230662.1|NP_003368.1	P49765	VEGFB_HUMAN	vascular endothelial growth factor B	77					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding			endometrium(2)|large_intestine(2)|prostate(1)|stomach(1)	6						ACTGTGCAGCGCTGTGGTGGC	0.682000													7	22					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70603878	70603878	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:70603878C>A	ENST00000449580.1	+	13	2062	c.2011C>A	c.(2011-2013)Ctc>Atc	p.L671I	TAF1_ENST00000423759.1_Missense_Mutation_p.L692I|TAF1_ENST00000276072.3_Missense_Mutation_p.L692I|TAF1_ENST00000373790.4_Missense_Mutation_p.L671I			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	671					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				ACCTCAGGACCTCACAGGCAA	0.428000													11	128					0.000673444	0.000688084	1	1	0
PADI3	51702	broad.mit.edu	37	1	17586195	17586195	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:17586195C>T	ENST00000375460.3	+	2	255	c.215C>T	c.(214-216)gCg>gTg	p.A72V		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	72					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CGCTTTGACGCGACTTTGGAG	0.597000													17	51					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31548884	31548884	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:31548884G>A	ENST00000429299.2	-	4	344	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	LTB_ENST00000483972.1_5'UTR|LTB_ENST00000446745.2_3'UTR	NM_002341.1	NP_002332.1	Q06643	TNFC_HUMAN	lymphotoxin beta (TNF superfamily, member 3)	113					cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9					Infliximab(DB00065)|Simvastatin(DB00641)	CCGCTCGTCAGAAACGCCTGT	0.682000													22	27					0	0	1	0	0
LGALS2	3957	broad.mit.edu	37	22	37967898	37967898	+	Nonsense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr22:37967898G>C	ENST00000215886.4	-	2	221	c.47C>G	c.(46-48)tCa>tGa	p.S16*		NM_006498.2	NP_006489.1	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	16	Galectin.									breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)	11	Melanoma(58;0.0574)					CTTCAGGGTTGACCCCGGCTT	0.572000													18	74					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68688010	68688010	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:68688010C>T	ENST00000361320.4	+	2	1914	c.1336C>T	c.(1336-1338)Cct>Tct	p.P446S	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	446						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						GAAGCGGTACCCTGCGAGCAT	0.537000													30	80					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25007085	25007085	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr22:25007085G>A	ENST00000400382.1	+	5	792	c.37G>A	c.(37-39)Gtg>Atg	p.V13M	GGT1_ENST00000406383.2_Missense_Mutation_p.V13M|GGT1_ENST00000400380.1_Missense_Mutation_p.V13M|GGT1_ENST00000248923.4_Missense_Mutation_p.V13M|GGT1_ENST00000400383.1_Missense_Mutation_p.V13M			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	13					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	CCTGCTGGCCGTGGTCCTGGT	0.627000													4	14					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62193700	62193700	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr20:62193700G>A	ENST00000467148.1	-	9	6407	c.6338C>T	c.(6337-6339)gCg>gTg	p.A2113V	HELZ2_ENST00000427522.2_Missense_Mutation_p.A1544V	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CAGCGGGGACGCCTCCTCTAG	0.677000													4	9					0	0	1	0	0
MED10	84246	broad.mit.edu	37	5	6374523	6374523	+	Silent	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:6374523G>T	ENST00000255764.3	-	3	333	c.223C>A	c.(223-225)Cga>Aga	p.R75R		NM_032286.2	NP_115662.2	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	75					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|urinary_tract(1)	5						TGGGGATTTCGACCTTGATCT	0.423000													9	120					1.05317e-09	1.11484e-09	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186106782	186106782	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:186106782C>G	ENST00000271588.4	+	88	13964	c.13735C>G	c.(13735-13737)Caa>Gaa	p.Q4579E	HMCN1_ENST00000367492.2_Missense_Mutation_p.Q4579E	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4579	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GCGAAACTGTCAAAATAAGCC	0.458000													9	48					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42605836	42605836	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr22:42605836G>A	ENST00000359486.3	-	1	5612	c.5476C>T	c.(5476-5478)Ccc>Tcc	p.P1826S	TCF20_ENST00000404876.1_Missense_Mutation_p.P127S|TCF20_ENST00000335626.4_Missense_Mutation_p.P1826S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1826					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GGCACGGAGGGCTTCGAGTCC	0.542000													8	199					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8993422	8993422	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:8993422G>A	ENST00000397910.4	-	66	41870	c.41667C>T	c.(41665-41667)atC>atT	p.I13889I	MUC16_ENST00000380951.5_Silent_p.I530I	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13892	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGCTCAGTGATGCTGTGGG	0.592000													23	172					0	0	1	0	0
PRKACA	5566	broad.mit.edu	37	19	14217608	14217608	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:14217608C>T	ENST00000308677.4	-	3	397	c.201G>A	c.(199-201)ggG>ggA	p.G67G	PRKACA_ENST00000590853.1_Intron|PRKACA_ENST00000589994.1_Silent_p.G59G|PRKACA_ENST00000350356.3_5'UTR	NM_002730.3	NP_002721.1	P17612	KAPCA_HUMAN	protein kinase, cAMP-dependent, catalytic, alpha	67	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16						CATAGTGGTTCCCGGTCTCCT	0.592000													6	84					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33391282	33391282	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:33391282C>T	ENST00000418600.2	+	2	197	c.96C>T	c.(94-96)acC>acT	p.T32T	SYNGAP1_ENST00000293748.5_Silent_p.T32T|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	32					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TGCACCGAACCCAATACGTTC	0.527000													13	203					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21460779	21460779	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:21460779G>A	ENST00000339374.6	+	5	759	c.526G>A	c.(526-528)Gag>Aag	p.E176K	METTL17_ENST00000382985.4_Missense_Mutation_p.E176K|METTL17_ENST00000556670.2_Missense_Mutation_p.E176K	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	176					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						AGCATTCCATGAGGTGAAAGT	0.453000													12	50					0	0	1	0	0
RING1	6015	broad.mit.edu	37	6	33176605	33176605	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:33176605G>A	ENST00000374656.4	+	2	214	c.6G>A	c.(4-6)acG>acA	p.T2T		NM_002931.3	NP_002922.2	Q06587	RING1_HUMAN	ring finger protein 1	2					histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			endometrium(5)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|skin(4)	17						TCACCATGACGACGCCGGCGA	0.652000													4	26					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23520183	23520183	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:23520183C>T	ENST00000374619.1	-	1	1039	c.530G>A	c.(529-531)cGg>cAg	p.R177Q	HTR1D_ENST00000314113.3_Missense_Mutation_p.R177Q	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	177					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity	p.R177Q(1)		NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CTTGGCCTGCCGCCAGAAGAG	0.597000													9	39					0	0	1	0	0
LRRC61	65999	broad.mit.edu	37	7	150034380	150034380	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:150034380C>G	ENST00000359623.4	+	3	1018	c.430C>G	c.(430-432)Ccc>Gcc	p.P144A	LRRC61_ENST00000493307.1_Missense_Mutation_p.P144A|LRRC61_ENST00000323078.7_Missense_Mutation_p.P144A	NM_001142928.1	NP_001136400.1	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	144	LRRCT.									endometrium(2)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CTGTGCCAACCCCTCCTACTG	0.657000													4	29					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645099	70645099	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:70645099C>T	ENST00000298596.6	+	3	1630	c.1547C>T	c.(1546-1548)aCg>aTg	p.T516M	STOX1_ENST00000399169.4_Missense_Mutation_p.T516M|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.T406M	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	516						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						ATTCAGAAGACGAGTGATCTG	0.438000													6	58					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926267	70926267	+	Missense_Mutation	SNP	T	T	C	rs78717717		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:70926267T>C	ENST00000603540.1	+	2	2309	c.2051T>C	c.(2050-2052)tTg>tCg	p.L684S	ADAM21_ENST00000267499.3_Missense_Mutation_p.L684S|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	684					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGAGTTTTTTTGCCGCTGATT	0.488000													7	58					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65537090	65537090	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr8:65537090G>A	ENST00000310193.3	-	2	302	c.129C>T	c.(127-129)ccC>ccT	p.P43P		NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	43					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity	p.P43P(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				GAGGCTCACCGGGTCTCCTAC	0.363000													17	122					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14798948	14798948	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:14798948C>T	ENST00000253697.3	+	13	2463	c.2011C>T	c.(2011-2013)Cgg>Tgg	p.R671W	C3orf20_ENST00000435614.1_Missense_Mutation_p.R549W|C3orf20_ENST00000412910.1_Missense_Mutation_p.R549W	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	671						cytoplasm|integral to membrane		p.R671W(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GCTGGTGCTGCGGAAGCTCAT	0.682000													12	51					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144808407	144808407	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr8:144808407G>A	ENST00000388913.3	-	5	3349	c.3224C>T	c.(3223-3225)cCg>cTg	p.P1075L		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	1075					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCCAGCAGCCGGTGGACGGCC	0.687000													4	29					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17616845	17616845	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:17616845G>T	ENST00000262077.2	-	21	4255	c.4256C>A	c.(4255-4257)gCa>gAa	p.A1419E	NUP153_ENST00000537253.1_Missense_Mutation_p.A1450E	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	1419					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GCTAGAATTTGCACCAAATGT	0.473000													9	90					9.70103e-10	1.03156e-09	1	1	0
CHAF1A	10036	broad.mit.edu	37	19	4423824	4423824	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:4423824G>A	ENST00000301280.5	+	7	1431	c.1330G>A	c.(1330-1332)Gaa>Aaa	p.E444K		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	444	Arg/Glu/Lys-rich.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGAAGGCCGAAATCACGAG	0.498000								Chromatin Structure					4	94					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105924819	105924819	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:105924819C>G	ENST00000526793.1	-	3	756	c.597G>C	c.(595-597)caG>caC	p.Q199H	KBTBD3_ENST00000531837.1_Missense_Mutation_p.Q199H|KBTBD3_ENST00000534815.1_Missense_Mutation_p.Q120H	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	195	BACK.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CCAGACATTTCTGTAGTACTC	0.323000													13	63					0	0	1	0	0
SETD3	84193	broad.mit.edu	37	14	99866585	99866585	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:99866585C>G	ENST00000331768.5	-	12	1348	c.1189G>C	c.(1189-1191)Gaa>Caa	p.E397Q		NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3	397					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				AGCAAGTGTTCTTTCAGTTCT	0.403000													11	123					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99521743	99521743	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:99521743C>T	ENST00000375231.1	-	6	2019	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	ZNF510_ENST00000223428.4_Missense_Mutation_p.E457K			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TAGGGTTTTTCTGCTGTATGA	0.393000													14	126					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42940217	42940217	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:42940217G>A	ENST00000426333.2	-	16	1768	c.1471C>T	c.(1471-1473)Cac>Tac	p.H491Y	EFTUD2_ENST00000402521.3_Missense_Mutation_p.H456Y|EFTUD2_ENST00000592576.1_Missense_Mutation_p.H481Y|EFTUD2_ENST00000591382.1_Missense_Mutation_p.H491Y	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	491						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CCAAAGGCGTGAAACTGGACT	0.562000													16	43					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160535272	160535272	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:160535272C>T	ENST00000368054.3	-	2	345	c.310G>A	c.(310-312)Gca>Aca	p.A104T	CD84_ENST00000311224.4_Missense_Mutation_p.A104T|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368051.3_Missense_Mutation_p.A104T|CD84_ENST00000534968.1_Intron|CD84_ENST00000368048.3_Missense_Mutation_p.A104T|CD84_ENST00000368047.3_5'UTR	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	104					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity	p.A104T(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TAGTCTCCTGCGTCTTCCATC	0.468000													65	222					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70004328	70004328	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:70004328C>G	ENST00000361484.3	-	1	614	c.291G>C	c.(289-291)ttG>ttC	p.L97F		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	97						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGAGCTGTTTCAAGGTGCACA	0.572000													14	148					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43298225	43298225	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:43298225G>A	ENST00000325110.6	-	4	666	c.460C>T	c.(460-462)Ctg>Ttg	p.L154L	HMGCS1_ENST00000433297.2_Silent_p.L154L	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	154					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						GCAACTACCAGGGCATACCGT	0.403000													14	54					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1730384	1730384	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:1730384G>A	ENST00000313288.4	+	4	1361	c.1255G>A	c.(1255-1257)Gga>Aga	p.G419R		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	419						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CATCCCGTTCGGAGGTGACAC	0.627000													20	93					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160969656	160969656	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:160969656G>A	ENST00000447678.1	-	32	5129	c.5009C>T	c.(5008-5010)gCc>gTc	p.A1670V	LPA_ENST00000316300.5_Missense_Mutation_p.A1670V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4178	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GCCTGTATCGGCATCTGGATT	0.522000													19	98					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6610395	6610395	+	Silent	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:6610395G>C	ENST00000433363.2	-	2	416	c.183C>G	c.(181-183)ctC>ctG	p.L61L	SLC13A5_ENST00000381074.4_Intron|SLC13A5_ENST00000573648.1_Silent_p.L61L|SLC13A5_ENST00000293800.6_Silent_p.L61L	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	61						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						AGACAGGCATGAGAGAGGTGA	0.527000													12	43					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	55					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438850	204438850	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:204438850G>A	ENST00000367187.3	-	3	637	c.81C>T	c.(79-81)gcC>gcT	p.A27A	PIK3C2B_ENST00000424712.2_Silent_p.A27A	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	27	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCAGGGCTTCGGCCATCGCTA	0.597000													14	60					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47117201	47117201	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr16:47117201C>T	ENST00000562435.1	-	9	1893	c.1509G>A	c.(1507-1509)gaG>gaA	p.E503E	NETO2_ENST00000303155.5_Silent_p.E496E	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	503						integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				CACAGGGAATCTCCTCCATTA	0.428000										HNSCC(25;0.065)			15	120					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694861	247694861	+	Missense_Mutation	SNP	G	G	A	rs147306837		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:247694861G>A	ENST00000366487.3	-	2	1314	c.953C>T	c.(952-954)gCg>gTg	p.A318V	GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A317V(1)		breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTAAATTTGCGCCAGCTTGCC	0.512000													17	67					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633211	143633211	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:143633211G>C	ENST00000408955.2	+	1	953	c.886G>C	c.(886-888)Gag>Cag	p.E296Q		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					AAGGAATAAAGAGGTGAAGGG	0.433000													18	55					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32390475	32390475	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:32390475C>T	ENST00000265069.8	-	12	2150	c.2048G>A	c.(2047-2049)cGa>cAa	p.R683Q		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	683					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		ATCTGGCATTCGGCGGCGATC	0.507000													27	73					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31621561	31621561	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:31621561C>G	ENST00000379416.3	-	5	359	c.311G>C	c.(310-312)aGa>aCa	p.R104T		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	104					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTTGGCAATTCTCTCCTAAAA	0.557000													29	117					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610576	10610576	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:10610576G>A	ENST00000171111.5	-	2	681	c.134C>T	c.(133-135)tCc>tTc	p.S45F	KEAP1_ENST00000393623.2_Missense_Mutation_p.S45F	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCCATGCTGGGAGGGCGTCAC	0.637000													7	112					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	879973	879973	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:879973C>T	ENST00000312090.6	-	8	1467	c.1317G>A	c.(1315-1317)acG>acA	p.T439T	MED16_ENST00000589119.1_Silent_p.T439T|MED16_ENST00000395808.3_Silent_p.T439T|MED16_ENST00000325464.1_Silent_p.T439T|MED16_ENST00000606828.1_Intron|MED16_ENST00000269814.4_Silent_p.T439T			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	439					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCCAGTGACGTCCACGATA	0.692000													5	11					0	0	1	0	0
NXF4	55999	broad.mit.edu	37	X	101821949	101821949	+	RNA	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:101821949C>T	ENST00000360035.2	+	0	1702					NR_002216.1															endometrium(2)|lung(8)	10						TGCATCCAAACGGTGAGCACC	0.498000													9	23					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186364068	186364068	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:186364068A>G	ENST00000265029.3	+	5	727	c.626A>G	c.(625-627)tAc>tGc	p.Y209C	FETUB_ENST00000382134.3_Missense_Mutation_p.Y144C|FETUB_ENST00000382136.3_Missense_Mutation_p.Y172C|FETUB_ENST00000539949.1_Missense_Mutation_p.Y61C|RP11-134F2.2_ENST00000428501.1_RNA|RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000450521.1_Missense_Mutation_p.Y209C	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	209	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TTTGTGGAATACTTAATTAAA	0.423000													38	169					0	0	1	0	0
ACVR2B	93	broad.mit.edu	37	3	38524631	38524631	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:38524631C>T	ENST00000352511.3	+	11	1819	c.1347C>T	c.(1345-1347)ggC>ggT	p.G449G		NM_001106.3	NP_001097.2	Q13705	AVR2B_HUMAN	activin A receptor, type IIB	449	Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		CTGCTTAGGGCCTGGCCCAGC	0.557000													5	187					0	0	1	0	0
TRMT2B	79979	broad.mit.edu	37	X	100274273	100274273	+	Splice_Site	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:100274273G>A	ENST00000338687.7	-	11	1958	c.1153_splice	c.e11+1	p.H385_splice	TRMT2B_ENST00000372936.3_Splice_Site_p.H430_splice|TRMT2B_ENST00000372939.1_Splice_Site_p.H385_splice|TRMT2B_ENST00000372935.1_Splice_Site_p.H430_splice|TRMT2B_ENST00000545398.1_Splice_Site_p.H430_splice|TRMT2B_ENST00000372931.5_Splice_Site_p.H430_splice			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	430							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						TCATCCTTACGCAGTCCGGCA	0.498000													10	82					0	0	1	0	0
CLN6	54982	broad.mit.edu	37	15	68506654	68506654	+	Missense_Mutation	SNP	C	C	T	rs140519790	by1000genomes	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:68506654C>T	ENST00000249806.5	-	3	428	c.271G>A	c.(271-273)Gtc>Atc	p.V91I	CLN6_ENST00000565471.1_Intron|RP11-315D16.2_ENST00000562767.1_Intron|CLN6_ENST00000418702.2_Silent_p.T56T|CLN6_ENST00000538696.1_Missense_Mutation_p.V123I|CLN6_ENST00000564752.1_Missense_Mutation_p.V91I|CLN6_ENST00000566347.1_Missense_Mutation_p.V91I	NM_017882.2	NP_060352.1	Q9NWW5	CLN6_HUMAN	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	91					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity			large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GGCGTGATGACGTTGTAGGCC	0.547000													12	42					0	0	1	0	0
UBQLN2	29978	broad.mit.edu	37	X	56590909	56590909	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:56590909G>T	ENST00000338222.5	+	1	884	c.603G>T	c.(601-603)atG>atT	p.M201I		NM_013444.3	NP_038472.2	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	201						cytoplasm|nucleus|plasma membrane	binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)	21						CCGATCTGATGAGGCAGCTCA	0.468000													12	81					7.03913e-09	7.41791e-09	1	1	0
METTL2B	55798	broad.mit.edu	37	7	128119373	128119373	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:128119373G>A	ENST00000480046.1	+	2	284	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	METTL2B_ENST00000262432.8_Missense_Mutation_p.E122K			Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	122							methyltransferase activity			breast(1)|cervix(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GAACAAGAGTGAAGTATGTGA	0.398000													14	83					0	0	1	0	0
IGHV3-11	28450	broad.mit.edu	37	14	106573465	106573465	+	RNA	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr14:106573465G>A	ENST00000390601.2	-	0	238																											GGCTGCACAGGAGAGTCTCAG	0.557000													45	204					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103988644	103988644	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:103988644T>C	ENST00000394785.3	-	2	695	c.64A>G	c.(64-66)Acg>Gcg	p.T22A	SLC9B2_ENST00000503103.1_Missense_Mutation_p.T22A|SLC9B2_ENST00000362026.3_Missense_Mutation_p.T22A|SLC9B2_ENST00000503230.1_Missense_Mutation_p.T22A|SLC9B2_ENST00000339611.4_Missense_Mutation_p.T22A|SLC9B2_ENST00000505838.1_5'UTR	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	22					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										ATGGAGGGCGTGTAATTCATT	0.368000													16	85					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371619	240371619	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:240371619C>T	ENST00000319653.9	+	5	3737	c.3507C>T	c.(3505-3507)ccC>ccT	p.P1169P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1169	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCTCTACCCGGAGCGGGCA	0.692000													3	13					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103234269	103234269	+	Silent	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:103234269C>A	ENST00000553106.1	-	12	1696	c.1224G>T	c.(1222-1224)cgG>cgT	p.R408R	PAH_ENST00000307000.2_Silent_p.R403R	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	408			R -> Q (in PKU; haplotypes 4,12).|R -> W (in PKU; haplotypes 1,2,4,5,13,34, 41,44; most common mutation).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CTGAGAAGGGCCGAGGTATTG	0.458000													16	68					1.52009e-12	1.64618e-12	1	1	0
TP53	7157	broad.mit.edu	37	17	7579369	7579369	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:7579369G>C	ENST00000420246.2	-	4	450	c.318C>G	c.(316-318)agC>agG	p.S106R	TP53_ENST00000269305.4_Missense_Mutation_p.S106R|TP53_ENST00000413465.2_Missense_Mutation_p.S106R|TP53_ENST00000359597.4_Missense_Mutation_p.S106R|TP53_ENST00000455263.2_Missense_Mutation_p.S106R|TP53_ENST00000445888.2_Missense_Mutation_p.S106R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	106	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		S -> G (in a sporadic cancer; somatic mutation).|S -> R (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.Q100fs*37(3)|p.G59fs*23(3)|p.S106R(3)|p.V73fs*9(1)|p.S106_Y107delSY(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAAACCGTAGCTGCCCTGGT	0.617000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	80					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151491225	151491225	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:151491225C>G	ENST00000271636.7	+	2	363	c.230C>G	c.(229-231)tCc>tGc	p.S77C		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	71	Head.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGCGGTGACTCCTTTGGGGTC	0.577000													9	52					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238245116	238245116	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:238245116G>A	ENST00000295550.4	-	40	9079	c.8627C>T	c.(8626-8628)cCg>cTg	p.P2876L	COL6A3_ENST00000472056.1_Missense_Mutation_p.P2269L|COL6A3_ENST00000346358.4_Missense_Mutation_p.P2676L|COL6A3_ENST00000409809.1_Missense_Mutation_p.P2670L|COL6A3_ENST00000353578.4_Missense_Mutation_p.P2670L|COL6A3_ENST00000347401.3_Missense_Mutation_p.P2675L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2876	Nonhelical region.|Thr-rich.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGTAGTCACCGGCTTCGTTGT	0.448000													58	143					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179377	90179377	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:90179377G>C	ENST00000370454.4	+	3	1503	c.1248G>C	c.(1246-1248)caG>caC	p.Q416H	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	416						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		AACTGAGGCAGAAGCTACAGA	0.403000													11	83					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175763877	175763877	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:175763877C>G	ENST00000443967.1	+	10	2676	c.2269C>G	c.(2269-2271)Cag>Gag	p.Q757E	SIMC1_ENST00000341199.6_Missense_Mutation_p.Q342E|SIMC1_ENST00000332772.4_Missense_Mutation_p.Q218E|SIMC1_ENST00000430704.2_Missense_Mutation_p.Q342E					SUMO-interacting motifs containing 1																		GCTCAAGTGTCAGGTACATTT	0.488000													5	43					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56712917	56712917	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:56712917G>A	ENST00000425394.2	-	24	3707	c.3331C>T	c.(3331-3333)Cga>Tga	p.R1111*	PAN2_ENST00000549090.1_Intron|PAN2_ENST00000548043.1_Nonsense_Mutation_p.R1111*|PAN2_ENST00000440411.3_Nonsense_Mutation_p.R1107*|PAN2_ENST00000257931.5_Nonsense_Mutation_p.R1110*	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	1111	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						ATTCGTTTTCGGGGCATATGG	0.498000													29	54					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129924970	129924970	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:129924970C>G	ENST00000281142.5	-	6	855	c.352G>C	c.(352-354)Gag>Cag	p.E118Q	SCLT1_ENST00000434680.1_Missense_Mutation_p.E118Q|SCLT1_ENST00000503215.1_Missense_Mutation_p.E95Q|SCLT1_ENST00000439369.2_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	118						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						GTTCCTACCTCTGTGCCCAGG	0.368000													15	89					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48704104	48704104	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:48704104G>A	ENST00000352832.5	+	34	7117	c.6745G>A	c.(6745-6747)Gac>Aac	p.D2249N	CACNA1G_ENST00000505165.1_Missense_Mutation_p.D2204N|CACNA1G_ENST00000515165.1_Missense_Mutation_p.D2283N|CACNA1G_ENST00000514079.1_Missense_Mutation_p.D2290N|CACNA1G_ENST00000503485.1_Missense_Mutation_p.D2249N|CACNA1G_ENST00000513964.1_Missense_Mutation_p.D2238N|CACNA1G_ENST00000442258.2_Missense_Mutation_p.D2242N|CACNA1G_ENST00000513689.2_Missense_Mutation_p.D2286N|CACNA1G_ENST00000429973.2_Missense_Mutation_p.D2265N|CACNA1G_ENST00000512389.1_Missense_Mutation_p.D2272N|CACNA1G_ENST00000507896.1_Missense_Mutation_p.D2193N|CACNA1G_ENST00000359106.5_Missense_Mutation_p.D2376N|CACNA1G_ENST00000358244.5_Missense_Mutation_p.D2170N|CACNA1G_ENST00000354983.4_Missense_Mutation_p.D2342N|CACNA1G_ENST00000515765.1_Missense_Mutation_p.D2320N|CACNA1G_ENST00000510366.1_Missense_Mutation_p.D2231N|CACNA1G_ENST00000515411.1_Missense_Mutation_p.D2313N|CACNA1G_ENST00000502264.1_Missense_Mutation_p.D2305N|CACNA1G_ENST00000510115.1_Missense_Mutation_p.D2297N|CACNA1G_ENST00000514717.1_Missense_Mutation_p.D2226N|CACNA1G_ENST00000360761.4_Missense_Mutation_p.D2260N|CACNA1G_ENST00000507609.1_Missense_Mutation_p.D2276N|CACNA1G_ENST00000507510.2_Missense_Mutation_p.D2331N|CACNA1G_ENST00000507336.1_Missense_Mutation_p.D2365N|CACNA1G_ENST00000514181.1_Missense_Mutation_p.D2258N	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2376					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGCAGACCTGGACCCCTGAGT	0.572000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	87					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272087	47272087	+	Silent	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chrX:47272087C>T	ENST00000377073.3	+	4	701	c.615C>T	c.(613-615)ctC>ctT	p.L205L		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	205					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GATCATACCTCATTGCTCATC	0.428000													4	37					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112064603	112064603	+	Splice_Site	SNP	C	C	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:112064603C>A	ENST00000357685.5	+	4	654	c.517_splice	c.e4-1	p.A173_splice	BCO2_ENST00000531169.1_Splice_Site_p.A139_splice|BCO2_ENST00000393032.2_Splice_Site_p.A139_splice|BCO2_ENST00000361053.4_Intron|BCO2_ENST00000438022.1_Splice_Site_p.A139_splice|BCO2_ENST00000526088.1_Splice_Site_p.A139_splice|SDHD_ENST00000532612.1_Intron|BCO2_ENST00000532593.1_Splice_Site_p.A68_splice			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	173					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						TGGTTTCAGCCATGACTGACA	0.423000													19	68					3.32936e-07	3.46194e-07	1	1	0
DUSP8	1850	broad.mit.edu	37	11	1586850	1586850	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr11:1586850G>A	ENST00000397374.3	-	2	334	c.207C>T	c.(205-207)ctC>ctT	p.L69L	DUSP8_ENST00000331588.4_Silent_p.L69L	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	69	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		CCGGCTGGATGAGCTCCGCAA	0.642000													4	24					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022129	76022129	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:76022129C>T	ENST00000393004.2	-	5	3640	c.3419G>A	c.(3418-3420)cGa>cAa	p.R1140Q	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.R1140Q|FILIP1_ENST00000370020.1_Missense_Mutation_p.R1041Q			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1140										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CTGGGTTCCTCGAGCAGATGA	0.562000													31	153					0	0	1	0	0
KPNA4	3840	broad.mit.edu	37	3	160231914	160231914	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:160231914G>A	ENST00000334256.4	-	13	1393	c.1088C>T	c.(1087-1089)gCa>gTa	p.A363V		NM_002268.4	NP_002259.1	O00629	IMA4_HUMAN	karyopherin alpha 4 (importin alpha 3)	363	NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)	22			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ATCAATTACTGCCTGTACCTG	0.363000													16	62					0	0	1	0	0
WDR76	79968	broad.mit.edu	37	15	44134857	44134857	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:44134857C>G	ENST00000263795.6	+	7	936	c.866C>G	c.(865-867)tCt>tGt	p.S289C	WDR76_ENST00000381246.2_Missense_Mutation_p.S225C	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	289										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		AAGGGATTATCTAGCATTAAA	0.284000											OREG0003949	type=REGULATORY REGION|Gene=AK124169|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	71					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156411951	156411951	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:156411951C>T	ENST00000461166.1	+	3	1648	c.1060C>T	c.(1060-1062)Cac>Tac	p.H354Y	TIPARP_ENST00000295924.7_Missense_Mutation_p.H354Y|TIPARP_ENST00000486483.1_Missense_Mutation_p.H354Y|TIPARP_ENST00000542783.1_Missense_Mutation_p.H354Y	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	354	WWE.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTGTAGGGACCACTTTGGATG	0.373000													16	207					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121502758	121502758	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr8:121502758G>A	ENST00000305949.1	+	13	1440	c.1395G>A	c.(1393-1395)caG>caA	p.Q465Q		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	465					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGATTGTACAGAGAGAGAAAC	0.328000													7	70					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142285059	142285059	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:142285059C>T	ENST00000350721.4	-	3	317	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	ATR_ENST00000383101.3_Missense_Mutation_p.V66M	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	66					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGCAACATCACGGAGGTTGGC	0.373000								Other conserved DNA damage response genes					15	79					0	0	1	0	0
POU5F2	134187	broad.mit.edu	37	5	93076292	93076292	+	Silent	SNP	G	G	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr5:93076292G>A	ENST00000510627.4	-	1	1051	c.978C>T	c.(976-978)ctC>ctT	p.L326L	FAM172A_ENST00000395965.3_Intron|POU5F2_ENST00000606183.1_5'UTR|FAM172A_ENST00000505869.1_Intron|FAM172A_ENST00000509163.1_Intron|FAM172A_ENST00000509739.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	326						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		CCTAAAATCTGAGGAGGCCCA	0.582000													5	46					0	0	1	0	0
WDR77	79084	broad.mit.edu	37	1	111986017	111986018	+	Splice_Site	INS	-	-	A			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr1:111986017_111986018insA	ENST00000235090.5	-	7	826		c.e7-1		WDR77_ENST00000411751.2_Splice_Site|WDR77_ENST00000497278.1_Splice_Site	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77						ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCACTGCAGCCTGCAAAGGAGA	0.475													2	4	---	---	---	---					
CASP8	841	broad.mit.edu	37	2	202131358	202131359	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr2:202131358_202131359delAA	ENST00000358485.4	+	2	522_523	c.326_327delAA	c.(325-327)gfs	p.E109fs	CASP8_ENST00000264275.5_Frame_Shift_Del_p.E50fs|CASP8_ENST00000264274.9_Frame_Shift_Del_p.E50fs|CASP8_ENST00000432109.2_Frame_Shift_Del_p.E50fs|CASP8_ENST00000392258.3_Frame_Shift_Del_p.E50fs|CASP8_ENST00000392259.2_Frame_Shift_Del_p.E50fs|CASP8_ENST00000323492.7_Frame_Shift_Del_p.E50fs|CASP8_ENST00000392266.3_Frame_Shift_Del_p.E50fs	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	50	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						AGACTCCAGGAAAAGAGAATGT	0.460										HNSCC(4;0.00038)			16	48	---	---	---	---					
PLXNA1	5361	broad.mit.edu	37	3	126751384	126751385	+	In_Frame_Ins	INS	-	-	CCT			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr3:126751384_126751385insCCT	ENST00000251772.4	+	29	5386_5387	c.5317_5318insCCT	c.(5317-5319)ctc>CCTctc	p.1773_1774insP	PLXNA1_ENST00000505278.1_3'UTR|PLXNA1_ENST00000393409.2_In_Frame_Ins_p.1796_1797insP			Q9UIW2	PLXA1_HUMAN	plexin A1	1796					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAAGGACTCACCCTCCAACAAG	0.624													22	81	---	---	---	---					
POU4F2	5458	broad.mit.edu	37	4	147560458	147560466	+	In_Frame_Del	DEL	GGCGGCGGC	GGCGGCGGC	-	rs67907220		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:147560458_147560466delGGCGGCGGC	ENST00000281321.3	+	1	414_422	c.166_174delGGCGGCGGC	c.(166-174)del	p.GGG65del	AC093887.1_ENST00000584185.1_RNA	NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	65	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					CGCTggtggtggcggcggcggcggcggcg	0.761													4	8	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187539265	187539266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr4:187539265_187539266insC	ENST00000441802.2	-	10	8683_8684	c.8474_8475insG	c.(8473-8475)gagfs	p.E2825fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2825	Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTACTCTACTTCCCCCTGGCAG	0.436										HNSCC(5;0.00058)			16	138	---	---	---	---					
HLA-B	3106	broad.mit.edu	37	6	31323353	31323354	+	Frame_Shift_Del	DEL	GT	GT	-	rs45610732	byFrequency	TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr6:31323353_31323354delGT	ENST00000412585.2	-	4	663_664	c.635_636delAC	c.(634-636)cfs	p.H212fs		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						GGTGGGTCACGTGTGTCTTTGG	0.589									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				93	113	---	---	---	---					
RELN	5649	broad.mit.edu	37	7	103629803	103629804	+	Translation_Start_Site	INS	-	-	GCCGCC			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr7:103629803_103629804insGCCGCC	ENST00000424685.2	-	0	159_160				RELN_ENST00000428762.1_Start_Codon_Ins|RELN_ENST00000343529.5_Start_Codon_Ins			P78509	RELN_HUMAN	reelin						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCGCTCCATgccgccgccgc	0.723													5	8	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)del	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													7	15	---	---	---	---					
C9orf106	414318	broad.mit.edu	37	9	132084723	132084731	+	RNA	DEL	CCAGTTCTG	CCAGTTCTG	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr9:132084723_132084731delCCAGTTCTG	ENST00000316786.1	+	0	684_692							Q8NAJ2	CI106_HUMAN	chromosome 9 open reading frame 106											large_intestine(1)|lung(1)|ovary(1)|skin(1)	4		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)				AAGAAAGTTCCCAGTTCTGCCTGTCCATC	0.565													12	57	---	---	---	---					
PIK3C2G	5288	broad.mit.edu	37	12	18435201	18435202	+	Frame_Shift_Ins	INS	-	-	T			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:18435201_18435202insT	ENST00000433979.1	+	2	302_303	c.186_187insT	c.(184-189)acttttfs	p.TF62fs	PIK3C2G_ENST00000266497.5_Frame_Shift_Ins_p.TF62fs|PIK3C2G_ENST00000535651.1_Frame_Shift_Ins_p.TF62fs|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000538779.1_Frame_Shift_Ins_p.TF62fs	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	62					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATGAAAACACCTTTTTTGTGCC	0.406													17	83	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													11	287	---	---	---	---					
XPOT	11260	broad.mit.edu	37	12	64812755	64812755	+	Frame_Shift_Del	DEL	T	T	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr12:64812755delT	ENST00000332707.5	+	6	899	c.370delT	c.(370-372)ttfs	p.F126fs		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	126	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.F126fs*6(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GTGGCCCAAGTTTTTTTTTGA	0.443													7	257	---	---	---	---					
MTMR10	54893	broad.mit.edu	37	15	31253221	31253222	+	In_Frame_Ins	INS	-	-	CCT			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr15:31253221_31253222insCCT	ENST00000435680.1	-	7	717_718	c.620_621insAGG	c.(619-621)gaa>gAGGaa	p.207_207E>EE	MTMR10_ENST00000425768.1_In_Frame_Ins_p.176_177insR|MTMR10_ENST00000563714.1_In_Frame_Ins_p.125_125E>EE|MTMR10_ENST00000314404.8_5'UTR	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	207	Poly-Gly.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CAGCTCCATTAcctcctcctcc	0.465													3	4	---	---	---	---					
LRRC37A11P	342666	broad.mit.edu	37	17	37196001	37196002	+	RNA	DEL	AG	AG	-	rs34712077		TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:37196001_37196002delAG	ENST00000425901.2	+	0	2604					NR_033753.2																						GAATACAGACAGAAAAGAATTT	0.327													7	1	---	---	---	---					
PRR11	55771	broad.mit.edu	37	17	57262426	57262426	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr17:57262426delC	ENST00000262293.4	+	3	452	c.140delC	c.(139-141)ttfs	p.S48fs		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	48										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GTCGGTATTTCTTCAATAGAT	0.378													7	133	---	---	---	---					
SALL3	27164	broad.mit.edu	37	18	76752542	76752543	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr18:76752542_76752543delGC	ENST00000536229.3	+	1	861_862	c.152_153delGC	c.(151-153)gfs	p.G51fs	SALL3_ENST00000537592.2_Frame_Shift_Del_p.G184fs|SALL3_ENST00000575389.2_Frame_Shift_Del_p.G184fs			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G184G(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TTCTCGCAGGGCGCGCGCGCGG	0.728													3	5	---	---	---	---					
NUMBL	9253	broad.mit.edu	37	19	41173866	41173868	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-UF-A7JO-01A-11D-A34J-08	TCGA-UF-A7JO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d43e084f-7f0f-4143-97c8-9351eedb0fac	3ee49030-1077-43c0-95ca-768a6e90504b	g.chr19:41173866_41173868delTGC	ENST00000252891.4	-	10	1502_1504	c.1335_1337delGCA	c.(1333-1338)caa>ca	p.QQ445del	NUMBL_ENST00000540131.1_In_Frame_Del_p.QQ404del|NUMBL_ENST00000598779.1_In_Frame_Del_p.QQ404del	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	445	Poly-Gln.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			TGAGgctgcttgctgctgttgct	0.670													4	6	---	---	---	---					
